A graphical dot matrix laser intervention therapy system

Abstract

The application discloses a kind of graphical dot matrix laser intervention treatment systems, belong to the technical field of pulse laser application.The system includes CO2 dot matrix laser instrument (1), CO2 dot matrix laser transmitter (2), operation platform (3), speckle imaging processor spectrometer (4), movable infrared identification detector (5), integrated image display (6), central integrated processor (7) and experimental demo (8).Central integrated processor is built-in based on 3D image instant modeling algorithm, temperature-flow rate double feedback PID algorithm and embedded AI model.The present application realizes individualized self-adapting microchannel by MEMS graphical microneedle array, realizes energy intelligent control by millisecond multi-modal laser switching, realizes dose precise adjustment by speckle spectrum real-time closed-loop feedback, solves the problem that pattern is not adjustable in prior art, energy switching delay is large, lacks real-time feedback, has the advantages of minimal tissue damage, high drug efficiency, individualized adaptation, real-time safety monitoring and the like.

Description

Technical Field

[0001] This invention relates to the technical field of pulsed laser applications, and more specifically to a patterned fractional laser interventional therapy system for transdermal drug delivery. Background Technology

[0002] At the graphic design level, existing microchannels generally use regular circular holes or rectangular arrays, which cannot conform to the curvature of the skin and the direction of veins in different areas, nor can they be dynamically adjusted according to individual differences in vein depth. The channel depth is usually set empirically at 100–300 μm, ignoring the difference of up to 500 μm between superficial veins in children and deep veins in obese individuals, resulting in ineffectiveness if too shallow and bleeding if too deep. At the same time, the pore density is fixed at 200–400 pores / cm², which is out of touch with the actual dosage requirements. High-dose drugs require multiple irradiations, which prolongs the operation time and increases the risk of thermal damage.

[0003] Regarding laser energy modulation, the optical parameters corresponding to the three functions of photothermal, ablation, and ablation differ significantly. Existing devices exhibit a delay of over 5 seconds in mode switching, failing to respond to lesion changes in real time. The resonance peaks of gold nanorods or polymer microspheres are prone to drift by ±5 nm under the influence of body temperature and blood flow, causing the laser coupling efficiency to drop by more than half. Furthermore, the photomechanical coupling efficiency between hydrogels and lasers is less than 30%, often requiring increased energy to reach the cavitation threshold, resulting in damage to surrounding healthy tissue.

[0004] Traditional drug delivery systems operate entirely in a "blind" manner: once the laser is activated, the operator can only set the power and time based on experience. They cannot know in real time whether the microchannels are truly open, whether the drug is actually injected, or whether the local blood flow velocity is too high, causing the drug to be washed away, or whether the blood vessels are about to rupture due to overheating. Without speckle spectroscopy and the lack of online quantitative methods for blood flow, temperature, and drug release, the result is often blindly increasing energy when the dosage is insufficient, or causing irreversible thermal damage when the dosage is excessive. Simultaneously, individual differences in skin thickness, vascular depth, and blood flow status are ignored, leading to significant differences in efficacy or frequent complications in different patients using the same parameters. In short, without the closed-loop feedback of speckle spectroscopy, it is impossible to upgrade from "experience-driven" to "data-driven," making precise, safe, and personalized transdermal drug delivery impossible. Summary of the Invention Based on the shortcomings of the existing technology, the technical problem solved by the present invention is to provide a graphical fractional laser interventional therapy system that can realize individualized adaptive microchannels, millisecond-level multimodal laser switching and real-time closed-loop feedback of speckle spectrum, so as to solve the problems of unadjustable pattern, large energy switching delay and lack of real-time feedback in the existing transdermal laser drug delivery.

[0005] To address the aforementioned technical problems, this invention provides a graphical fractional laser interventional therapy system, comprising: A CO2 dot matrix laser instrument (1) has a CO2 dot matrix laser emitter (2); the CO2 dot matrix laser emitter (2) is installed inside or at the front end of the CO2 dot matrix laser instrument (2). Operating platform (3); Speckle imaging processor spectrometer (4); Mobile infrared identification detector (5); Integrated image display (6); Central integrated processor (7); And experimental demo (8), experimental demo (8) is used for system debugging and parameter calibration, and is not a necessary component for clinical treatment; The central integrated processor (7) is electrically connected to the CO2 dot matrix laser (1), the speckle imaging processor spectrometer (4), the movable infrared recognition detector (5), and the integrated image display (6), respectively. The CO2 dot matrix laser emitter (2) is connected to the CO2 dot matrix laser (1).

[0006] As a preferred embodiment of the above technical solution, the graphical fractional laser interventional therapy system provided by the present invention further includes some or all of the following technical features: As an improvement to the above technical solution, the central integrated processor 7 incorporates a real-time modeling algorithm module based on 3D images of the patient's skin and veins. The algorithm module outputs control commands to adjust the pore depth, pore diameter, and pore density of the MEMS micropore array and liquid crystal elastomer microneedles in real time. The MEMS micropore array has a hexagonal honeycomb structure or a fractal structure, with a micropore depth of 100-150 μm and a pore density of 200-400 pores / cm³. 2 It is dynamically adjustable within the specified range.

[0007] As an improvement to the above technical solution, the CO2 array laser (1) has a wide-band, nanosecond-level tunable laser source and a closed-loop driving circuit, which can seamlessly switch between wavelength, pulse width and power in less than 20ms between photothermal mode, ablation mode and stripping mode.

[0008] As an improvement to the above technical solution, the central integrated processor (7) has a built-in temperature-flow rate dual feedback PID algorithm module, which is used to compensate for the energy loss caused by microsphere resonance drift and hydrogel coupling efficiency changes in real time.

[0009] As an improvement to the above technical solution, the speckle imaging processor spectrometer (4) includes a high frame rate CMOS and a fiber optic spectrometer, which are used to synchronously acquire speckle contrast signals, photoacoustic temperature maps and drug fluorescence signals at a sampling frequency greater than 100Hz.

[0010] As an improvement to the above technical solution, the central integrated processor (7) has an embedded AI model built in, which is used to fuse the speckle contrast signal, photoacoustic temperature map and drug fluorescence signal into a dose-risk index, and send laser power increase / decrease or shutdown commands to the CO2 array laser instrument (1) in microseconds based on the index.

[0011] The present invention also includes a graphical fractional laser interventional treatment method based on the system described in any of the preceding claims, comprising the following steps: Step 1: Initial parameter setting - Set the laser parameters according to the drug and skin characteristics, and start the monitoring system of the speckle imaging processor spectrometer (4); Step 2: Laser irradiation and micropore formation - Micropores are formed by irradiating the skin with a CO2 array laser emitter (2), while the speckle imaging processor spectrometer (4) monitors skin changes in real time; Step 3: Real-time monitoring and feedback - Analyze blood flow and tissue changes using speckle spectral data collected by speckle imaging processor spectrometer (4), evaluate the micropore formation effect, and automatically adjust laser parameters if the effect is not ideal; Step 4: Parameter adjustment and optimization - Adjust the laser energy density and pulse width parameters based on feedback, and continue monitoring until the micropore formation and drug penetration effect reach the preset standard; Step 5: Drug delivery and follow-up monitoring - The drug penetrates through micropores, and the speckle imaging processor spectrometer (4) continuously monitors the skin response to ensure safety and efficacy; Step 6: System shutdown and evaluation – After achieving the expected results, shut down the system, summarize the data, and evaluate the treatment effect.

[0012] As a preferred embodiment of the above technical solution, the graphical fractional laser interventional treatment method based on the above system provided by the present invention further includes some or all of the following technical features: As an improvement to the above technical solution, before setting the laser parameters in step 1, the method further includes acquiring three-dimensional image data of the patient's skin or veins through a movable infrared recognition detector (5), and generating individualized micropore array control parameters by running an instant modeling algorithm through a central integrated processor (7).

[0013] As an improvement to the above technical solution, the automatic adjustment of laser parameters in step 3 includes: seamlessly switching between photothermal mode, ablation mode and stripping mode in less than 20ms, and compensating for energy loss in real time through a temperature-flow rate dual feedback PID algorithm.

[0014] As an improvement to the above technical solution, the specific method for analyzing blood flow and tissue changes through speckle spectral data in step 3 is as follows: simultaneously acquire speckle contrast signal, photoacoustic temperature map and drug fluorescence signal at a sampling frequency greater than 100Hz, integrate the three into a dose-risk index through an embedded AI model, and determine the increase or decrease of laser power or shutdown based on the index within microseconds.

[0015] Compared with the prior art, the technical solution of the present invention has the following beneficial effects: 1. Minimal tissue damage: Through MEMS-LCE double-layer microneedles and 3D-2D conformal mapping, the depth of the micropores is precisely locked at 100-150μm, penetrating only the stratum corneum without touching the dermal blood vessels, reducing the wound area by more than 90%, with no eschar or bleeding, and immediate healing after the operation.

[0016] 2. Drug delivery efficiency is equal to or even higher: Through laser-microsphere resonance and hydrogel photomechanical coupling, while reducing the micropore diameter by 80%, the local energy density is increased by 3 times, and the drug penetration flux is equal to or better than that of traditional large wound laser.

[0017] 3. Zero wounds and zero scabs after surgery: Through millisecond-level switching of femtosecond three-band laser and closed-loop temperature control, the laser energy is changed from empirical setting to real-time closed-loop, avoiding excessive thermal coagulation; the micropores close within 30 minutes, and the epidermis is completely regenerated within 24 hours, with no risk of infection and no need for dressings.

[0018] 4. Personalized and precise fit: Through 3D skin-vein scanning, the MEMS pore depth / pore density can be adjusted in real time. The same set of equipment can automatically match the superficial veins of children (<200μm) or the deep veins of obese people (>500μm).

[0019] 5. Real-time safety monitoring: Through a speckle-spectrum-photoacoustic three-in-one probe and edge AI, blood flow, temperature and drug concentration are synchronously fed back at a frequency of 1kHz. In case of abnormality, the power will be automatically reduced or the machine will be shut down within 1ms.

[0020] The above description is merely an overview of the technical solution of the present invention. In order to better understand the technical means of the present invention and to implement it in accordance with the contents of the specification, and to make the above and other objects, features and advantages of the present invention more apparent and understandable, the following detailed description is provided in conjunction with preferred embodiments. Attached Figure Description

[0021] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings of the embodiments will be briefly described below.

[0022] Figure 1 shows a comparison of rat skin wound surfaces and speckle patterns under conventional laser transdermal drug delivery and drug delivery via this system. (The figures are not included in the provided text.) Figure 1aRat skin wounds treated with traditional laser transdermal drug delivery; Figure 1b This is a speckle spectrum of rat skin wounds treated with conventional laser transdermal drug delivery. Figure 1c Skin wounds of rats treated with a graphical fractional laser interventional therapy system; Figure 1d A speckle spectrum of rat skin wounds after administration of a graphical fractional laser interventional therapy system.

[0023] Figure 2 This image shows a comparison of thrombus color under drug-containing and drug-free conditions between traditional laser transdermal drug delivery and drug delivery via this system. (The image includes the image itself.) The image on the left shows traditional laser transdermal drug delivery (without medication). The second from the left shows the administration of medication (without drug) using the graphical fractional laser interventional therapy system. The third from the left is traditional laser transdermal drug delivery (drug administration); The fourth image from the left shows the administration of medication using the graphical fractional laser interventional therapy system.

[0024] Figure 3 This is a schematic diagram of the structure of the graphical fractional laser interventional therapy system device of the present invention.

[0025] In the picture: 1. CO2 fractional laser instrument; 2. CO2 dot matrix laser emitter; 3. Operating platform; 4. Speckle imaging processor spectrometer; 5. Portable infrared recognition detector; 6. Integrated image display; 7. Central Integrated Processing Unit; 8. Experiment demo. Detailed Implementation

[0026] The following detailed description of specific embodiments of the present invention is part of this specification. The principles of the present invention are illustrated through examples, and other aspects, features and advantages of the present invention will become apparent from this detailed description.

[0027] The equipment selected in this embodiment of the invention is: Keying KL series, medical grade, Guoguang EMP-JZ-2, and Jiaguang JC40 / JC40D.

[0028] Example 1 System Construction See Figure 3This embodiment provides a graphical fractional laser interventional therapy system. A CO2 fractional laser instrument (1) and a CO2 fractional laser emitter (2) are connected and installed on an operating platform (3). A speckle imaging processor spectrometer (4) includes a high frame rate CMOS and a fiber optic spectrometer, and its signal output is connected to a central integrated processor (7). The output of a movable infrared recognition detector (5) is also connected to the central integrated processor (7). The output of the central integrated processor (7) is connected to the integrated image display (6) and the control input of the CO2 fractional laser instrument (1), respectively. An experimental demo (8) is placed within the detection range of the CO2 fractional laser emitter (2) and the speckle imaging processor spectrometer (4).

[0029] Example 2 Working Process First, a three-dimensional image of the skin / vein in the area to be treated is acquired by a movable infrared recognition detector (5) and transmitted to a central integrated processor (7). The central integrated processor (7) runs a built-in real-time modeling algorithm to generate control parameters (pore depth, pore diameter, density) of a MEMS micropore array or liquid crystal elastomer microneedle that match the individual's skin curvature and vein depth, and outputs them to a CO2 fractional laser (1).

[0030] After the system is started, the CO2 fractional laser emitter (2) irradiates the skin in a fractional pattern according to the initial parameters, forming a micropore array. At the same time, the speckle imaging processor spectrometer (4) synchronously collects speckle contrast (blood flow signal), photoacoustic temperature map and drug fluorescence signal at a sampling frequency greater than 100Hz, and transmits them to the central integrated processor (7) in real time. The embedded AI model in the central integrated processor (7) fuses the above three signals into a dose-risk index. When the index exceeds the preset safety threshold, the central integrated processor (7) sends laser power increase / decrease or shutdown commands to the CO2 fractional laser (1) within microseconds to achieve closed-loop control.

[0031] After the drug is administered, the system automatically summarizes the treatment data and displays it on the integrated imaging display (6).

[0032] Specifically, firstly, a mobile infrared recognition detector (5) collects three-dimensional image data of the skin / veins in the area to be treated on the patient and transmits it to the central integrated processor (7). The central integrated processor (7) runs a built-in real-time modeling algorithm to generate MEMS micropore array control parameters (pore depth, pore diameter, density) that match the individual's skin curvature and vein depth, and outputs them to the CO2 fractional laser (1).

[0033] After the system is started, the CO2 dot matrix laser emitter (2) irradiates the skin in a dot matrix manner according to the initial parameters to form a micropore array. At the same time, the speckle imaging processor spectrometer (4) synchronously collects speckle contrast (blood flow signal), photoacoustic temperature map and drug fluorescence signal at a sampling frequency greater than 100Hz and transmits them to the central integrated processor (7) in real time. The embedded AI model [6.1] in the central integrated processor (7) fuses the above three signals into a dose-risk index. When the index exceeds the preset safety threshold, the central integrated processor (7) sends a laser power increase / decrease or shutdown command to the CO2 dot matrix laser (1) within microseconds to realize closed-loop control.

[0034] After the drug is administered, the system automatically summarizes the treatment data and displays it on the integrated imaging display (6).

[0035] Example 3: Animal Experiment Results A comparative transdermal drug delivery experiment was conducted using SD rats. The experiment was divided into four groups: conventional laser transdermal drug delivery (no drug), systemic drug delivery (no drug), conventional laser transdermal drug delivery (drug delivery), and systemic drug delivery (drug delivery). The drug administered was a thrombolytic model drug. The results are shown in Figure 1 and... Figure 2 As shown.

[0036] Figure 1 shows a comparison of rat skin wound surfaces and speckle patterns under conventional laser transdermal drug delivery and drug delivery via this system. (The figures are not included in the provided text.) Figure 1a Rat skin wounds treated with traditional laser transdermal drug delivery; Figure 1b This is a speckle spectrum of rat skin wounds treated with conventional laser transdermal drug delivery. Figure 1c Skin wounds of rats treated with a graphical fractional laser interventional therapy system; Figure 1d A speckle spectrum of rat skin wounds after administration of a graphical fractional laser interventional therapy system.

[0037] Figure 2 This image shows a comparison of thrombus color under drug-containing and drug-free conditions between traditional laser transdermal drug delivery and drug delivery via this system. (The image includes the image itself.) The first from the left is traditional laser transdermal drug delivery (without drug); the second from the left is drug delivery via the graphic fractional laser interventional therapy system (without drug); the third from the left is traditional laser transdermal drug delivery (with drug); and the fourth from the left is drug delivery via the graphic fractional laser interventional therapy system (with drug).

[0038] Figure 3 This is a schematic diagram of the structure of the graphical fractional laser interventional therapy system device of the present invention.

[0039] In the figure: 1. CO2 dot matrix laser instrument; 2. CO2 dot matrix laser emitter; 3. Operating platform; 4. Speckle imaging processor spectrometer; 5. Movable infrared recognition detector; 6. Integrated image display; 7. Central integrated processor; 8. Experimental demo.

[0040] Figure 1a The image shows that traditional laser treatment caused a continuous, irregular, large-area carbonization and coagulation necrosis zone, with a wound diameter of about 2.5 mm and obvious edema around the wound. Figure 1c The system showed that after drug administration, almost no open wounds were visible, with only a uniformly distributed array of 100-150μm micropores remaining, without carbonization or bleeding. Figure 1b The speckle spectrum showed large areas of high-contrast dark regions, suggesting that conventional laser treatment caused significant blood flow stasis or microthrombus formation. Figure 1d The speckle pattern maintains uniform low contrast, with only localized, reversible blood flow enhancement observed in the micropore region. Figure 2 The results show that, while achieving the same therapeutic effect (similar degree of thrombus color lightening), this system can deliver drugs precisely to the target area without damaging dermal blood vessels.

[0041] The above results show that, under the same dosage conditions, this system reduces the skin wound area by >90% and blood flow disturbance by >80%, achieving precise transdermal drug delivery without wounds, bleeding, or scab formation.

[0042] All the raw materials listed in this invention, as well as the upper and lower limits and ranges of the raw materials and the upper and lower limits and ranges of the process parameters (such as temperature, time, etc.), can realize this invention. Examples are not listed one by one here.

[0043] The above description is merely a preferred embodiment of the present invention, and should not be construed as limiting the scope of the invention. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of the present invention, and these improvements and modifications are also considered to be within the scope of protection of the present invention.

Claims

1. A graphical fractional laser interventional therapy system, characterized in that, include: CO2 array laser instrument (1), which has a CO2 array laser emitter (2). Operating platform (3); Speckle imaging processor spectrometer (4); Mobile infrared identification detector (5); Integrated image display (6); Central integrated processor (7); The central integrated processor (7) is electrically connected to the CO2 dot matrix laser (1), the speckle imaging processor spectrometer (4), the movable infrared recognition detector (5), and the integrated image display (6), respectively. The CO2 dot matrix laser emitter (2) is connected to the CO2 dot matrix laser (1).

2. The graphic fractional laser interventional therapy system according to claim 1, characterized in that, The central integrated processor (7) has a built-in real-time modeling algorithm module based on 3D images of the patient's skin or veins. This module generates control commands for MEMS micropore arrays or liquid crystal elastomer microneedles that can change the pore depth, pore size, and density in real time. The MEMS micropore array has a hexagonal honeycomb structure or a fractal structure with a micropore depth of 100-150 μm and a pore density of 200-400 pores / cm³. 2 It is dynamically adjustable within the specified range.

3. The graphic fractional laser interventional therapy system according to claim 1, characterized in that, The CO2 array laser (1) has a wide-band, nanosecond-level tunable laser source and a closed-loop drive circuit, which can seamlessly switch between wavelength, pulse width and power in less than 20ms between photothermal mode, ablation mode and stripping mode.

4. The graphic fractional laser interventional therapy system according to claim 3, characterized in that, The central integrated processor (7) has a built-in temperature-flow rate dual feedback PID algorithm module, which is used to compensate for energy loss caused by microsphere resonance drift and hydrogel coupling efficiency changes in real time.

5. The graphic fractional laser interventional therapy system according to claim 1, characterized in that, The speckle imaging processor spectrometer (4) includes a high frame rate CMOS and a fiber optic spectrometer, used to synchronously acquire speckle contrast signals, photoacoustic temperature maps and drug fluorescence signals at a sampling frequency greater than 100 Hz.

6. The graphic fractional laser interventional therapy system according to claim 5, characterized in that, The central integrated processor (7) has an embedded AI model built in, which is used to fuse speckle contrast signal, photoacoustic temperature map and drug fluorescence signal into a dose-risk index, and send laser power increase / decrease or shutdown command to CO2 array laser instrument (1) in microseconds based on the index.

7. A graphical fractional laser interventional treatment method based on the system described in any one of claims 1 to 6, characterized in that, Includes the following steps: Step 1: Initial parameter setting - Set the laser parameters according to the drug and skin characteristics, and start the monitoring system of the speckle imaging processor spectrometer (4); Step 2: Laser irradiation and micropore formation - Micropores are formed by irradiating the skin with a CO2 array laser emitter (2), while the speckle imaging processor spectrometer (4) monitors skin changes in real time; Step 3: Real-time monitoring and feedback - Analyze blood flow and tissue changes using speckle spectral data collected by speckle imaging processor spectrometer (4), evaluate the micropore formation effect, and automatically adjust laser parameters if the effect is not ideal; Step 4: Parameter adjustment and optimization - Adjust the laser energy density and pulse width parameters based on feedback, and continue monitoring until the micropore formation and drug penetration effect reach the preset standard; Step 5: Drug delivery and follow-up monitoring - The drug penetrates through micropores, and the speckle imaging processor spectrometer (4) continuously monitors the skin response to ensure safety and efficacy; Step 6: System shutdown and evaluation – After achieving the expected results, shut down the system, summarize the data, and evaluate the treatment effect.

8. The graphic fractional laser interventional treatment method according to claim 7, characterized in that, Before setting the laser parameters in step 1, the process also includes acquiring three-dimensional image data of the patient's skin or veins through a movable infrared recognition detector (5), and generating individualized micropore array control parameters by running an instant modeling algorithm through a central integrated processor (7).

9. The graphic fractional laser interventional treatment method according to claim 7, characterized in that, The automatic adjustment of laser parameters in step 3 includes seamless switching between photothermal mode, ablation mode and stripping mode in less than 20ms, and real-time compensation of energy loss through a temperature-flow rate dual feedback PID algorithm.

10. The graphic fractional laser interventional treatment method according to claim 7, characterized in that, The specific method for analyzing blood flow and tissue changes through speckle spectral data in step 3 is as follows: simultaneously acquire speckle contrast signal, photoacoustic temperature map and drug fluorescence signal at a sampling frequency greater than 100Hz, fuse the three into a dose-risk index through an embedded AI model, and determine the increase or decrease of laser power or shutdown based on the index within microseconds.

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