Oral composition

Abstract

[Problem] To provide an oral composition which more effectively exerts an anti-glycation effect of a gluconate salt on dentin, exerts a yellowing-inhibiting effect inside a tooth, and exerts an anti-aging effect. [Solution] An oral composition comprising (A) a gluconate salt and (B) one or more selected from the group consisting of a metaphosphate salt and a phytate salt, the content of the (A) component being 0.2 to 5 mass% relative to the total mass of the oral composition, and the content of the (B) component being 0.1 to 5 mass% relative to the total mass of the oral composition.

Description

Technical Field

[0001] This invention relates to oral compositions. Background Technology

[0002] Gluconate is a component that inhibits yellowing of teeth (whitening effect) by suppressing the glycation reaction in dentin.

[0003] For example, Patent Document 1 describes an oral composition comprising sodium fluoride, calcium gluconate, and condensed phosphate.

[0004] Existing technical documents

[0005] Patent documents

[0006] Patent Document 1: Japanese Patent Application Publication No. 2026-1570 Summary of the Invention

[0007] The problem the invention aims to solve

[0008] However, for oral compositions, there is a requirement to exert an inhibitory effect on the formation of aging-causing substances, namely advanced glycation end products (AGEs), which are generated by the binding and denaturation of sugars and proteins (anti-aging effect), and to further enhance the whitening effect.

[0009] The purpose of this invention is to provide an oral composition that more effectively exerts the anti-glycation effect of gluconate on dentin, inhibits yellowing inside teeth, and exerts anti-aging effects.

[0010] Solution for solving the problem

[0011] The tooth surface has a coating of stains and organic matter, which acts as a barrier, making it difficult for gluconate to fully penetrate into the dentin.

[0012] The inventors focused on this point and investigated the effect of combining gluconate with a specific phosphate. Their results showed that the specific phosphate temporarily relaxes the barrier structure of the tooth surface through a chelating effect, thereby increasing the permeability of the tooth surface and allowing gluconate to easily reach the dentin.

[0013] The present invention has the following aspects.

[0014] [1] An oral composition comprising:

[0015] (A) gluconate, and

[0016] (B) Select one or more from the group consisting of metaphosphate and phytate.

[0017] The content of component (A) is 0.2 to 5% by mass relative to the total mass of the oral composition.

[0018] The content of component (B) is 0.1 to 5% of the total mass of the oral composition.

[0019] [2] The oral composition according to [1], wherein the (A) component is one or more selected from the group consisting of calcium gluconate, sodium gluconate, copper gluconate and zinc gluconate.

[0020] [3] The oral composition according to [1] or [2], wherein the ratio expressed as [content (mass%) of component (A)] / [content (mass%) of component (B)] is 0.1 to 10.

[0021] [4] The oral composition according to any one of [1] to [3] further comprises (C) one or more of the group consisting of alumina and sodium bicarbonate.

[0022] [5] The oral composition according to [4], wherein the content of component (C) is 0.1 to 1 by mass relative to the total mass of the oral composition.

[0023] [6] The oral composition according to [4] or [5], wherein the ratio expressed as [content of (A) component (mass%)] / [content of (B) component (mass%) + content of (C) component (mass%)] is 0.1 to 1.

[0024] [7] The oral composition according to any one of [1] to [6], wherein the content of component (A) is 0.5 to 5 by mass relative to the total mass of the oral composition.

[0025] [8] The oral composition according to any one of [1] to [7], wherein the content of component (B) is 0.5 to 5% by mass.

[0026] The effects of the invention

[0027] According to the present invention, an oral composition can be obtained that more effectively exerts the anti-glycation effect of gluconate on dentin, inhibits yellowing inside the tooth, and exerts anti-aging effects. Detailed Implementation

[0028] The following provides a detailed description of various exemplary embodiments, features, and methods of the present invention. The term "exemplary" as used in this specification means "used as an example, embodiment, or illustration." Any embodiment described as "exemplary" in this specification should not be construed as superior or better than other embodiments.

[0029] Furthermore, to better illustrate the present invention, numerous specific details are shown in the following detailed descriptions. Those skilled in the art will understand that the present invention can be practiced in the same manner even without these specific details. In other instances, to emphasize the spirit of the invention, methods, means, apparatus, and steps well-known to those skilled in the art are not described in detail.

[0030] Unless otherwise stated, all units used in this specification are international standard units, and it should be understood that the numerical values ​​and ranges appearing in this invention include systematic errors that are unavoidable in industrial production.

[0031] In this specification, the word "may" has both the meaning of performing a certain process and the meaning of not performing a certain process.

[0032] In this specification, references to "some specific / preferred embodiments," "other specific / preferred embodiments," and "embodiment" refer to specific elements (e.g., features, structures, properties, and / or characteristics) associated with that embodiment, which are included in at least one embodiment described herein and may or may not be present in other embodiments. Furthermore, it should be understood that the described elements can be combined with various embodiments in any suitable manner.

[0033] In this specification, the range of values ​​represented by "value A to value B" refers to the range including the endpoint values ​​A and B.

[0034] In this specification, "oral composition" means a composition intended primarily for use in the oral cavity.

[0035] Oral Compositions

[0036] The oral composition of this embodiment comprises component (A) and component (B).

[0037] <(A) ingredient>

[0038] (A) is a gluconate. (A) is a component that inhibits yellowing of the tooth interior by suppressing glycation reactions in the dentin. (A) and (B) work synergistically to exert an anti-aging effect through whitening and anti-glycation effects within the tooth interior.

[0039] Component (A) can include calcium gluconate, sodium gluconate, copper gluconate, and zinc gluconate. Among these, calcium gluconate is preferred because it readily dissociates from gluconate ions and calcium ions are beneficial to teeth.

[0040] (A) The ingredient may be present in the oral composition as a balanced mixture with gluconolactone.

[0041] (A) The ingredients can be a single type or a combination of two or more types.

[0042] The content of component (A) is 0.2 to 5% by mass relative to the total mass of the oral composition, preferably 0.5 to 5% by mass. By keeping the content of component (A) within the above range, the glycation reaction in the dentin can be inhibited, thereby exerting an inhibitory effect on yellowing of the tooth interior.

[0043] If the content of component (A) is less than 0.2% by mass, the yellowing inhibition effect inside the tooth, the whitening effect inside the tooth, and the anti-aging effect brought about by anti-glycation will not be obtained. If the content of component (A) is greater than 5% by mass, the solubility in solvents will be poor when manufacturing oral compositions.

[0044] In some preferred embodiments, the content of (A) relative to the total mass of the oral composition is preferably 0.3% by mass or more, 0.4% by mass or more, 0.5% by mass or more, 0.6% by mass or more, 0.7% by mass or more, 0.8% by mass or more, 0.9% by mass or more, 1% by mass or more, 1.1% by mass or more, 1.2% by mass or more, 1.3% by mass or more, 1.4% by mass or more, 1.5% by mass or more, 1.6% by mass or more, 1.7% by mass or more, 1.8% by mass or more, 1.9% by mass or more, 2% by mass or more, 2.1% by mass or more, or 2.2% by mass or more, and preferably 4.9% by mass or less, or 4.8% by mass or less. Below 4.7%, 4.6%, 4.5%, 4.4%, 4.3%, 4.2%, 4.1%, 4%, 3.9%, 3.8%, 3.7%, 3.6%, 3.5%, 3.4%, 3.3%, 3.2%, 3.1%, 3%, 2.9%, 2.8%, 2.7%, 2.6%, 2.5%, 2.4%, or 2.3%.

[0045] <(B) Components>

[0046] (B) Component is selected from one or more of the groups consisting of metaphosphate and phytate. Component (B) temporarily relaxes the barrier structure of the tooth surface through chelation, thereby increasing the permeability of the tooth surface and allowing component (A) to easily reach the dentin. Thus, through whitening and anti-glycation effects inside the tooth, it exerts an anti-aging effect.

[0047] Metaphosphoric acid refers to phosphoric acid composed of the general formula (HPO3). nThe term refers to a polymer of phosphoric acid, where n is a number greater than or equal to 3. Examples of metaphosphoric acids include trimetaphosphate and hexametaphosphate.

[0048] Examples of salts include inorganic alkali salts such as sodium and potassium salts, alkaline earth metal salts such as calcium and magnesium salts, and organic alkali salts such as triethylammonium salts, triethanolamine salts, pyridinium salts, and diisopropylammonium salts. Among these, alkali metal salts or alkaline earth metal salts are preferred, and sodium or potassium salts are more preferred.

[0049] Component (B) can include potassium metaphosphate, sodium metaphosphate, potassium phytate, sodium phytate, etc. Among them, sodium metaphosphate and sodium phytate are preferred.

[0050] (B) The ingredients can be a single type or a combination of two or more types.

[0051] The content of component (B) is 0.1 to 5% by mass, preferably 0.5 to 5% by mass. By keeping the content of component (B) within the above range, the glycation reaction in the dentin can be inhibited, thereby exerting an inhibitory effect on yellowing inside the tooth.

[0052] If the content of component (B) is less than 0.1% by mass, the yellowing inhibition effect inside the teeth, the whitening effect inside the teeth, and the anti-aging effect brought about by anti-glycation will not be obtained. If the content of component (B) is greater than 5% by mass, the possibility of mucosal peeling during use is high, and the safety and user experience are reduced.

[0053] In some preferred embodiments, the content of (B) is preferably 0.2% by mass or more, 0.3% by mass or more, 0.4% by mass or more, 0.5% by mass or more, 0.6% by mass or more, 0.7% by mass or more, 0.8% by mass or more, 0.9% by mass or more, 1% by mass or more, 1.1% by mass or more, 1.2% by mass or more, 1.3% by mass or more, 1.4% by mass or more, 1.5% by mass or more, 1.6% by mass or more, 1.7% by mass or more, 1.8% by mass or more, 1.9% by mass or more, 2% by mass or more, 2.1% by mass or more, 2.2% by mass or more, 2.3% by mass or more, 2.4% by mass or more, or... More than 2.5% by mass, preferably less than 4.9% by mass, less than 4.8% by mass, less than 4.7% by mass, less than 4.6% by mass, less than 4.5% by mass, less than 4.4% by mass, less than 4.3% by mass, less than 4.2% by mass, less than 4.1% by mass, less than 4% by mass, less than 4% by mass, less than 3.9% by mass, less than 3.8% by mass, less than 3.7% by mass, less than 3.6% by mass, less than 3.5% by mass, less than 3.4% by mass, less than 3.3% by mass, less than 3.2% by mass, less than 3.1% by mass, less than 3% by mass, less than 2.9% by mass, less than 2.8% by mass, less than 2.7% by mass, or less than 2.6% by mass.

[0054] In some preferred embodiments, the ratio expressed as [content (mass%) of component (A)] / [content (mass%) of component (B)] is preferably 0.1 to 10. By setting the ratio in this way, component (A) and component (B) work synergistically, and based on the whitening effect and anti-glycation effect inside the teeth, it is easy to exert an anti-aging effect.

[0055] In some preferred embodiments, the ratio expressed as [content (mass%) of component (A)] / [content (mass%) of component (B)] is preferably 0.5 or more, 1 or more, 1.5 or more, 2 or more, 2.5 or more, 3 or more, 3.5 or more, 4 or more, 4.5 or more, or 5 or more, and preferably 9.5 or less, 9 or less, 8.5 or less, 8 or less, 7.5 or less, 7 or less, 6.5 or less, 6 or less, or 5.5 or less.

[0056] <(C) Ingredients>

[0057] In some preferred embodiments, the oral composition of the present invention may further comprise (C) one or more selected from the group consisting of alumina and sodium bicarbonate. Component (C) physically removes fine stains and organic coatings from the tooth surface, thereby improving tooth surface cleanliness.

[0058] (C) The ingredients can be a single type or a combination of two or more types.

[0059] The content of component (C) is preferably 0.1 to 3% by mass relative to the total mass of the oral composition. By setting the content of component (C) within the above range, fine stains on the tooth surface can be easily and effectively removed, and excessive abrasion of the tooth surface can be suppressed.

[0060] In some preferred embodiments, the content of (C) relative to the total mass of the oral composition is preferably 0.2% by mass or more, 0.3% by mass or more, 0.4% by mass or more, 0.5% by mass or more, 0.6% by mass or more, 0.7% by mass or more, 0.8% by mass or more, 0.9% by mass or more, 1% by mass or more, 1.1% by mass or more, 1.2% by mass or more, 1.3% by mass or more, 1.4% by mass or more, or 1.5% by mass or more, and preferably 2.9% by mass or less, 2.8% by mass or less, 2.7% by mass or less, 2.6% by mass or less, 2.5% by mass or less, 2.4% by mass or less, 2.3% by mass or less, 2.2% by mass or less, 2.1% by mass or less, 2% by mass or less, 1.9% by mass or less, 1.8% by mass or less, 1.7% by mass or less, or 1.6% by mass or less.

[0061] The ratio, expressed as [content of component (A) (mass%)] / [content of component (B) (mass%) + content of component (C) (mass%)], is preferably 0.1 to 1. By setting the ratio in this way, components (A), (B), and (C) work synergistically, and based on the whitening and anti-glycation effects inside the teeth, they can easily exert an anti-aging effect.

[0062] In some preferred embodiments, the ratio expressed as [content of component (A) by mass %) / [content of component (B) by mass %) + content of component (C) by mass %) is preferably 0.2 or more, 0.3 or more, 0.4 or more, or 0.5 or more, and preferably 0.9 or less, 0.8 or less, 0.7 or less, or 0.6 or less.

[0063] <Other Ingredients>

[0064] In the oral composition of the present invention, other ingredients commonly used in oral compositions may be incorporated as needed, without impairing the effects of the present invention. Examples of optional ingredients that may be incorporated include solvents, abrasives (abrasive silica, etc.), binders (thickening silica, xanthan gum, etc.), humectants (sorbitol, glycerin, etc.), sweeteners (saccharin, etc.), flavorings (flavoring compositions), pH adjusters, preservatives (methylparaben, etc.), active ingredients (sodium monofluorophosphate, etc.), and surfactants (sodium lauryl sulfate, etc.).

[0065] Dosage Forms of Oral Compositions

[0066] The oral composition of this embodiment can be manufactured into any suitable dosage form known in the conventional method. Examples of dosage forms include liquids (solutions, emulsions, suspensions, slurries, etc.), semi-solids (gels, ointments, pastes, etc.), and solids (tablets, granules, capsules, films, mixtures, molten solids, waxy solids, elastic solids, soft capsules, etc.). In this embodiment, the dosage form of the oral composition is preferably a liquid or semi-solid.

[0067] The oral composition of this embodiment can be widely used in oral applications. Examples of solid dosage forms include troche tablets, gummies, chewing gum, and dental cleaning agents. Examples of semi-solid dosage forms include toothpaste and gel-based dental cleaning agents. Examples of liquid dosage forms include mouthwash, liquid dental cleaning agents, and mouthwashes (sprays, etc.). From the viewpoint of effectiveness and stability, toothpaste and gel-based dental cleaning agents are preferred.

[0068] In this embodiment, when the oral composition is a semi-solid, and the oral composition is prepared into a liquid state, the pH (25°C) of the oral composition is preferably 5.0 to 9.0, more preferably 6.0 to 8.0. This maintains effectiveness and stability. The pH can be measured immediately after preparation of the oral composition using a pH meter (model Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd., after 3 minutes at 25°C. The pH can be adjusted by adding the described pH adjuster, component composition, etc.

[0069] The oral composition of this embodiment can be adjusted to an appropriate viscosity, for example, depending on the dosage form. When the dosage form is, for example, a paste, gel, or ointment, the viscosity at 25°C, measured using a BH viscometer, is preferably 1 Pa·s to 300 Pa·s, more preferably 20 Pa·s to 150 Pa·s.

[0070] In addition, when the oral composition is in liquid form, the viscosity at 25°C as measured by a BH viscometer should be 1000 mPa·s or less, and is particularly preferably 0.7 to 1000 mPa·s.

[0071] Methods for manufacturing oral compositions

[0072] The method for manufacturing the oral composition of the present invention is not particularly limited, and it can be manufactured by mixing the above-mentioned ingredients. The mixing order of the ingredients is not particularly limited, but uniform mixing is preferred.

[0073] When the oral composition of the present invention is a toothpaste composition, it can be manufactured by any suitable method known in the past. Specifically, as a method for manufacturing the toothpaste composition, for example, the following manufacturing method can be listed: first, the components soluble in a solvent are manufactured, then insoluble components other than these are mixed, and defoaming is performed as needed, for example, by reducing pressure.

[0074] The resulting toothpaste can be manufactured into a product by storing it in a specified container (laminated tube).

[0075] There are no particular limitations on the shape or material of the container that can hold the toothpaste composition of the present invention. Any suitable container known in the past that is generally suitable for toothpaste compositions can be used as the container. Examples of containers include plastic containers made of polyethylene, polypropylene, polyethylene terephthalate, and nylon.

[0076] When the oral composition of the present invention is a liquid oral composition, the manufacturing method thereof may be, for example, the following method: the raw material components are added sequentially to a solvent such as purified water and stirred to dissolve them uniformly.

[0077] There are no particular limitations on the shape or material of the container for holding the oral composition containing the liquid of the present invention. Generally, it can be used in containers applied to oral compositions. Specifically, such containers can be laminated containers containing layers of polyethylene, ethylene methacrylate copolymer, polyethylene terephthalate, aluminum, glass vapor deposited layer, polyvinyl alcohol, ethylene ethylene alcohol copolymer, acrylonitrile copolymer, paper, recycled plastic, etc.; or polyethylene containers, polyethylene terephthalate containers, polypropylene containers; or bag containers containing linear polyethylene, low-density polyethylene, high-density polyethylene, etc., of polyethylene or polypropylene. Tubular containers, mechanical or pressure differential dispenser containers, pillow-type packaging, and other film packaging containers can also be used as various containers commonly used in oral compositions.

[0078] Methods for cleaning teeth

[0079] The present invention provides a method for cleaning teeth, comprising applying the oral composition of the present invention to the tooth surface.

[0080] When the oral composition of the present invention is a liquid dosage form such as a mouthwash, for example, a method of holding an appropriate amount in the mouth for 10 to 30 seconds and rinsing can be described. When the oral composition of the present invention is a solid dosage form such as a toothpaste or a semi-solid dosage form such as toothpaste, for example, an appropriate amount can be applied (attached) to the teeth and then brushed.

[0081] Example

[0082] The embodiments of the present invention will be described in detail below with reference to examples. Those skilled in the art will understand that the following examples are merely illustrative and should not be considered as limiting the scope of the invention. Where specific conditions are not explicitly stated in the examples, general conditions or conditions specified by the manufacturer are followed. Unless otherwise specified by the manufacturer, the reagents or equipment used are generally commercially available products.

[0083] It should be noted that in the following examples, unless otherwise specified, "%" as the unit of content means "mass %".

[0084] <Ingredients Used>

[0085] [(A) Ingredient]

[0086] Calcium gluconate: Manufactured by Zhengzhou Ruipu Biological Engineering Co., Ltd.

[0087] Sodium gluconate: manufactured by Jungbunzlauer Shandong Fuyang Bio-tech and Xingfa Group.

[0088] Copper gluconate: Manufactured by Hebei Chuanghai Biotechnology Co., Ltd.

[0089] Zinc gluconate: Manufactured by Hebei Chuanghai Biotechnology Co., Ltd.

[0090] [(B) Component]

[0091] Sodium metaphosphate: manufactured by Hubei Xingfa Chemicals.

[0092] Sodium phytate: manufactured by Changsha Weier Fine Chemical Co., Ltd.

[0093] [(C) Component]

[0094] Alumina: Manufactured by Nippon Light Metal Company, Ltd.

[0095] Sodium bicarbonate: Manufactured by Guanxi Man Ting Fang Fine Chemical Co., Ltd.

[0096] [water]

[0097] Purified water.

[0098] [Common Ingredients (Optional Ingredients)]

[0099] Sorbitol solution (70% by mass aqueous solution): manufactured by ROQUETTE.

[0100] Glycerin: Produced by Wilmar International Limited.

[0101] Thickening silica: Made by Evonik, product number: Zeodent (registered trademark) 165.

[0102] Abrasive silica: Made by Evonik, trade name: Zeodent (registered trademark) 103.

[0103] Xanthan gum: Produced by Xinjiang Meihua Amino Acid Co., Ltd.

[0104] Sodium monofluorophosphate: manufactured by Hubei Xingfa Chemical Group Co., Ltd.

[0105] Sodium lauryl sulfate (K12), manufactured by Dongming Juhua Chemical Co., Ltd.

[0106] Sodium saccharin: Henan Kaifeng Pingmei Shenma Xinghua Fine Chemical Co., Ltd.

[0107] Methylparaben: Manufactured by Zhejing Shengxiao Chemicals Co., Ltd.

[0108] Fragrance composition: Fragrance composition A as described in Table 4

[0109] <Examples 1-15, Comparative Examples 1-3>

[0110] Using the above-mentioned ingredients as raw materials, toothpaste compositions having the formulations shown in Tables 1-3 below were prepared. Water-soluble ingredients (excluding binders, fragrance compositions, surfactants, and abrasives in Tables 1-3) were added to purified water and stirred. Then, binders, fragrance compositions, surfactants, and abrasives were added, and the mixture was further stirred under reduced pressure (4 kPa) to obtain the toothpaste composition. A 5L capacity kneader (manufactured by Ishiyama Works Co., Ltd.) was used in the manufacturing process.

[0111] Empty columns in the table indicate that the ingredient was not mixed. The "balance" of purified water indicates that the total amount of the oral composition is 100%.

[0112] The obtained toothpaste composition was evaluated as follows. The results are recorded in the table.

[0113] <Evaluation Methods>

[0114] Evaluation Method 1: Yellowing Inhibition Test of Bovine Teeth

[0115] The toothpaste compositions of Examples 1-12 and Comparative Examples 1-3 were evaluated for their anti-yellowing effects on teeth using the following methods.

[0116] The attached gingiva and root portion of the extracted tooth are removed to create a dentin block containing enamel and dentin. A block approximately 6mm × 6mm × 3mm in size is cut from the center of the crown, with the enamel surface serving as the test surface. The test surface is polished using water-resistant abrasive paper (#800, #2000, #4000) to homogenize the surface.

[0117] Alternately perform steps A and B below to allow stain to adhere to the test surface. Perform steps A and B three times each day for two days (a total of six times each).

[0118] <Step A>

[0119] Add 300 μL of saliva (Medix Biochemica USA Inc., product number: 991-05-P) to the test surface, seal it with a sealant, and incubate at 37°C for 2 hours.

[0120] <Step B>

[0121] Add 300 μL of black tea extract from Brisk tea bags (manufactured by Unilever Japan Co., Ltd.) according to the conditions stated on the packaging to the test surface after step A above, and incubate at 37°C for 1 hour.

[0122] The glycation solution was prepared using PBS (pH 7.4). The glycation solution contained 9% ribose, 5% glucose, 1% bovine serum albumin, and 0.5% trioleic acid glyceride.

[0123] The toothpaste composition was diluted 3 times with the above-mentioned saccharification solution, centrifuged, and the resulting supernatant was used as the test solution.

[0124] The stained dentin blocks were immersed in 2 mL of the test solution and reacted at 37°C for 7 days.

[0125] Brush 50 times using an automatic grinding tester (Miyagawa Shoten Co., Ltd., load 200g, temperature 37°C) equipped with a flat-cut toothbrush (PC Clinica, manufactured by Lion Corporation).

[0126] The test surface was photographed before the reaction (before saccharification) and after the reaction (after saccharification and washing) using a digital microscope (KEYENCE VHX-2000). The values ​​of L*, a*, and b* were determined by image analysis, and ΔE was calculated using the following formula. Measurements were also performed on a fixed area in the center of the test surface.

[0127] It can be said that the lower the ΔE value, the higher the effect of inhibiting internal yellowing.

[0128]

[0129] (L1,a1,b1: before saccharification, L2,a2,b2: after saccharification)

[0130] Those with a ΔE value below 12 are considered qualified.

[0131] Evaluation Method 2: AGEs (Advanced Glycation End Products) Formation Inhibition Assay

[0132] The toothpaste compositions of Examples 1-12 and Comparative Examples 1-3 were evaluated for their AGEs generation inhibition effect by the following method.

[0133] The glycation solution was prepared using PBS (pH 7.4). The glycation solution contained 9% ribose, 5% glucose, 1% bovine serum albumin, and 0.5% trioleic acid glyceride.

[0134] The toothpaste composition was diluted 3 times with the above-mentioned saccharification solution, centrifuged, and the resulting supernatant was used as the test solution.

[0135] Two dentin blocks, prepared using the same method as evaluation method 1, after staining, were each immersed in 2 mL of the following solution and reacted at 37°C for 7 days:

[0136] (i) Saccharified solution (composition without added toothpaste: saccharification control)

[0137] (ii) Test solution.

[0138] After the reaction, 6N HCl solution (20 μL / mg tooth weight) was added to the dentin block, and hydrolysis was carried out at 110°C for 16 hours. The resulting solution was measured using a microplate reader (FlexStation3, Molecular Devices). The fluorescence at 385 nm produced by irradiation with 335 nm excitation light (measurement index: pentosidine) was measured. The obtained fluorescence intensity was compared with that of 9% ribose solution and various test solutions.

[0139] The amount of AGEs generated was calculated as a relative value with the fluorescence intensity of the glycation control group set to "1".

[0140] It can be said that the lower the relative AGEs value, the higher the anti-aging effect.

[0141] Relative AGEs value = (fluorescence intensity of each experimental group) / (fluorescence intensity of the glycation control group)

[0142] A relative value below 0.8 is considered acceptable.

[0143] [Table 1]

[0144]

[0145] [Table 2]

[0146]

[0147] [Table 3]

[0148]

[0149] As shown in Tables 1 and 2, the toothpaste compositions of Examples 1-12 exhibit excellent effects in inhibiting internal yellowing and AGEs formation.

[0150] As shown in Table 3, in Comparative Example 1, where the content of component (A) was 0.1% by mass, the effects of inhibiting internal yellowing and inhibiting AGEs formation were both poor.

[0151] In Comparative Example 2, which does not contain component (B), the effects of inhibiting internal yellowing and inhibiting AGEs formation were both poor.

[0152] (B) In Comparative Example 3, where the content of component B was 0.05% by mass, the effects of inhibiting internal yellowing and inhibiting AGEs formation were both poor.

[0153] As can be seen from the above, the toothpaste composition of the present invention has excellent effects in inhibiting yellowing of the tooth interior and anti-aging.

[0154] Furthermore, in Example 1 above, flavoring compositions B to X, as described in Tables 4 to 6, were used to replace flavoring composition A, and toothpaste compositions with the same composition were prepared. The results showed excellent inhibition of internal yellowing and inhibition of AGEs formation. The compositions of flavorings 1 to 9 and solvent 1, as described in Tables 4 to 6, are shown in Tables 7 to 16.

[0155] It should be noted that "removing a% fore-fraction" in the table refers to removing the initial a% when fractionating essential oils, and "removing b% fore-fraction / rear fraction" refers to removing the initial b% and the final b% when fractionating essential oils.

[0156] [Table 4]

[0157]

[0158] [Table 5]

[0159]

[0160] [Table 6]

[0161]

[0162] [Table 7]

[0163]

[0164] [Table 8]

[0165]

[0166] [Table 9]

[0167]

[0168] [Table 10A]

[0169]

[0170] [Table 10B]

[0171]

[0172] [Table 11]

[0173]

[0174] [Table 12]

[0175]

[0176] [Table 13A]

[0177]

[0178] [Table 13B]

[0179]

[0180] [Table 14A]

[0181]

[0182] [Table 14B]

[0183]

[0184] [Table 14C]

[0185]

[0186] [Table 14D]

[0187]

[0188] [Table 14E]

[0189]

[0190] [Table 14F]

[0191]

[0192] [Table 14G]

[0193]

[0194] [Table 14H]

[0195]

[0196] [Table 14I]

[0197]

[0198] [Table 14J]

[0199]

[0200] [Table 15]

[0201]

[0202] [Table 16]

[0203]

[0204] It should be noted that the technical means of the present invention have been described through specific examples, but those skilled in the art will understand that the present invention is not limited thereto.

[0205] The embodiments of the present invention have been described above, but these descriptions are exemplary and not exhaustive, and are not limited to the disclosed embodiments. Various modifications and variations will be apparent to those skilled in the art without departing from the scope and spirit of the described embodiments. The terminology used in this specification is chosen to best explain the principles of the embodiments, practical applications, or market improvements, or to enable those skilled in the art to understand the embodiments disclosed herein.

Claims

1. An oral composition comprising: (A) gluconate, and (B) Select one or more from the group consisting of metaphosphate and phytate. The content of component (A) is 0.2 to 5% by mass relative to the total mass of the oral composition. The content of component (B) is 0.1 to 5% of the total mass of the oral composition.

2. The oral composition according to claim 1, wherein, The component (A) is selected from one or more of the group consisting of calcium gluconate, sodium gluconate, copper gluconate and zinc gluconate.

3. The oral composition according to claim 1, wherein, The ratio expressed as [content of component (A) (mass%)] / [content of component (B) (mass%)] is 0.1 to 10.

4. The oral composition according to claim 1, further comprising (C) one or more selected from the group consisting of alumina and sodium bicarbonate.

5. The oral composition according to claim 4, wherein, The content of component (C) is 0.1 to 3% of the total mass of the oral composition.

6. The oral composition according to claim 4, wherein, The ratio expressed as [content of component A (mass%)] / [content of component B (mass%) + content of component C (mass%)] is 0.1 to 1.

7. The oral composition according to claim 1, wherein, The content of component (A) is 0.5 to 5% of the total mass of the oral composition.

8. The oral composition according to claim 1, wherein, The content of component (B) is 0.5~5% by mass.

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