Cordyceps militaris small molecule peptide skin cream for promoting transdermal absorption and preparation method thereof

Abstract

The application discloses a kind of promoting transdermal absorption's Cordyceps militaris small molecule peptide skin cream and preparation method thereof, belong to cosmetic technical field.Skin cream's matrix component includes beeswax, lanolin, petrolatum, cetyl alcohol, mineral oil, olive oil, sorbitan oleate, phenoxyethanol and deionized water, active component is lavender essential oil and Cordyceps militaris small molecule peptide powder.The water-soluble Cordyceps militaris small molecule peptide is wrapped in internal water phase by water-in-oil emulsification system, combines multiple mechanisms such as hair follicle bypass opening, stratum corneum hydration enhancement and surface sustained hydration, actively promotes the transdermal absorption of hydrophilic peptide, realizes the gradient moisturizing of " first wetting after supplementing ".Meanwhile, the bionic lipid component in matrix synchronously repairs skin barrier, realizes the dual-effect synergy of " physical boost delivery + chemical signal regulation ".After human efficacy test verification, facial skin water content is significantly improved after 7 days, deep pigment is reduced.Through third party detection, product meets the standard requirements of QB / T 1857-2013 " skin cream ".

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, specifically to a skin cream containing small molecule peptides from Cordyceps militaris that promotes transdermal absorption and its preparation method. Background Technology

[0002] Cordyceps militaris is a medicinal and edible fungus containing various bioactive components such as cordyceps polysaccharides, cordycepin, adenosine, sterols, and superoxide dismutase. In recent years, the application of Cordyceps militaris extract in skincare has received widespread attention. Existing research indicates that Cordyceps militaris extract possesses excellent antioxidant, anti-inflammatory, and antibacterial bioactivities, and can be used to prepare skincare products with anti-aging and whitening effects.

[0003] Regarding the development and utilization of active ingredients from Cordyceps militaris, researchers have attempted to apply Cordyceps militaris peptides to skincare products. For example, CN115337220A discloses a Cordyceps peptide composition, which involves compounding donkey-hide gelatin, Cordyceps militaris mycelium, and egg white, followed by enzymatic hydrolysis with pepsin to obtain a filtrate with a molecular weight cutoff of less than 5 kDa. CN121022958A discloses a method for preparing Cordyceps active peptides using a low-temperature freeze-drying process combined with fermentation by Saccharomyces cerevisiae and Lactobacillus acidophilus. In addition, studies have reported the application potential of Cordyceps militaris extract in skin whitening (see Shen S et al., Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial, 2025) and anti-oxidation (see Eiam K et al., Cordyceps militaris Extract for Skin Pathogenic Bacteria and Antioxidant Activities, Journal of Fungi 2022, 8, 327).

[0004] However, the aforementioned existing technologies still have the following shortcomings:

[0005] First, the problem of transdermal absorption of water-soluble small molecule peptides has not yet been effectively solved. Although small molecule peptides have excellent biological activity, their strong hydrophilicity makes it difficult for them to directly penetrate the lipid bilayer of the stratum corneum. In existing technologies, Cordyceps militaris peptides are mostly added in the form of aqueous solutions or simple creams, lacking a delivery system design specifically for the transdermal absorption of peptide active ingredients, resulting in low bioavailability of the active ingredients.

[0006] Secondly, the synergistic effect of the matrix system and peptide active ingredients in existing Cordyceps militaris skincare products is insufficient. Most products simply add Cordyceps militaris extract to conventional skincare matrix, failing to fully leverage the matrix components' role in promoting transdermal absorption of active ingredients, and also failing to achieve the dual synergistic effect of the matrix itself (biomimetic lipid repair) and peptide active ingredients (signal regulation).

[0007] Third, there is a lack of product designs that combine both "physical delivery booster + chemical signal regulation" mechanisms. An ideal skincare product should not only actively promote the transdermal absorption of active ingredients, but also simultaneously repair the skin barrier and exert anti-aging effects. However, existing Cordyceps militaris skincare products have not yet achieved the organic integration of these mechanisms. Summary of the Invention

[0008] This invention addresses the technical problems of low transdermal absorption rate of water-soluble Cordyceps militaris small molecule peptides and lack of synergistic effect between matrix system and active ingredients in the prior art, and provides a skin care cream of Cordyceps militaris small molecule peptides that promotes transdermal absorption and its preparation method.

[0009] This invention constructs a specific water-in-oil (W / O) emulsion matrix system to actively promote the transdermal absorption of hydrophilic Cordyceps militaris small molecule peptides, while simultaneously utilizing the biomimetic lipid components in the matrix to repair the skin barrier, achieving a dual synergistic effect of "physical delivery booster + chemical signal regulation".

[0010] To achieve the above-mentioned objectives, the present invention provides the following technical solution:

[0011] A skin cream containing small molecule peptides from Cordyceps militaris that promotes transdermal absorption, composed of a base component and an active component;

[0012] The matrix components, by weight, include: 10-14 parts beeswax, 10-14 parts lanolin, 24-32 parts petrolatum (white petrolatum), 12-18 parts cetyl alcohol, 55-65 parts mineral oil (liquid paraffin), 4-6 parts olive oil, 3-5 parts sorbitan oleate (Span 80), 0.8-1.2 parts phenoxyethanol, and 60-70 parts deionized water;

[0013] The active ingredients include lavender essential oil and Cordyceps militaris small molecule peptide powder.

[0014] The amount of lavender essential oil added is 1.0%-2.0% of the total weight of the matrix;

[0015] The amount of Cordyceps militaris small molecule peptide powder added is 2.0%-3.5% of the total weight of the matrix.

[0016] Preferably, the matrix components are as follows, by weight:

[0017] 12 parts beeswax, 12 parts lanolin, 28 parts white petrolatum, 15 parts cetyl alcohol, 60 parts liquid paraffin, 5 parts olive oil, 4 parts Span 80, 1.0 part phenoxyethanol, 65 parts deionized water.

[0018] The Cordyceps militaris small molecule peptide powder can be prepared using methods known in the art, such as, but not limited to, compound enzymatic hydrolysis, microbial fermentation, or ultrafiltration membrane separation.

[0019] As a preferred embodiment of the present invention, the preparation method of the Cordyceps militaris small molecule peptide powder can be obtained by referring to the preparation method disclosed in the applicant's previous patent application (application number: 202610284637.0), the entire contents of which are incorporated herein by reference.

[0020] The preparation method of the skin cream includes the following steps:

[0021] (1) Preparation of oil phase: weigh out the beeswax, lanolin, petrolatum, cetyl alcohol, mineral oil, olive oil and sorbitan oleate according to the formula, mix them and heat to 75-85℃, stir until completely melted and mixed evenly to obtain the oil phase;

[0022] (2) Aqueous phase preparation: Heat deionized water to 75-85℃;

[0023] (3) Emulsification: Under stirring conditions, the aqueous phase is slowly added to the oil phase, the temperature is maintained at 75-85℃, and the mixture is continuously stirred and emulsified for 15-30 minutes to form a water-in-oil emulsion matrix;

[0024] (4) Cooling and adding ingredients: Cool the emulsion system to 40-50℃, add lavender essential oil, Cordyceps militaris small molecule peptide powder and phenoxyethanol, and stir evenly;

[0025] (5) Shaping: Continue stirring until room temperature to obtain the skin cream.

[0026] Preferably, in step (3), a high-speed homogenizer is used for emulsification, with a homogenization speed of 5000-15000 rpm and a homogenization time of 3-10 minutes.

[0027] The transdermal absorption-promoting mechanism of the skin cream described in this invention is as follows:

[0028] (a) The protective and gradient release effect of the water-in-oil (W / O) system

[0029] This formulation uses sorbitan oleate (Span 80) as a lipophilic emulsifier to construct a water-in-oil emulsion system. Water-soluble Cordyceps militaris small molecule peptides are dissolved in the inner phase of deionized water and encapsulated by the continuous oil phase. This structure has dual advantages: (1) the oil phase isolates the external environment, preventing the peptides from hydrolyzing or oxidizing during storage and use; (2) after application, the oil phase fuses with the skin lipids, and with the help of the interference of hexadecyl alcohol and lavender essential oil on the stratum corneum, the inner aqueous phase is gradually exposed, forming a local high concentration of peptide aqueous solution on the skin surface, establishing a transdermal concentration gradient, and achieving gradient moisturizing of "first moisturizing and then replenishing".

[0030] (ii) Opening of bypass pathways for hair follicles and sweat glands

[0031] Water-soluble small molecule peptides have difficulty penetrating the lipid barrier between stratum corneum cells, but skin appendages such as hair follicles and sweat gland ducts can serve as secondary bypass channels, allowing peptides to accumulate locally in the hair follicles. Mineral oil and petrolatum in the matrix can soften and hydrate the keratin at the hair follicle opening through a occlusive moisturizing effect, enhancing the transdermal absorption efficiency of small molecule peptides. Cetyl alcohol and lavender essential oil can alter the permeability of the stratum corneum barrier, thereby increasing the penetration potential of ingredients through skin appendages to some extent.

[0032] (III) Enhanced hydration of the stratum corneum and formation of aqueous micropores

[0033] Lanolin, olive oil, and beeswax work synergistically to seal in moisture, significantly enhancing the hydration of the stratum corneum. When the water content of the stratum corneum increases, its dense structure expands and forms temporary aqueous micropores, sufficient to allow water-soluble small molecule peptides to pass through. This mechanism does not rely on lipid pathways, but utilizes the "hydration-pore" principle to achieve transdermal transport of water-soluble active ingredients.

[0034] (iv) Increased surface residence time and enhanced passive diffusion

[0035] The sealing film formed by petrolatum and mineral oil can maintain the skin surface in a moist state for several hours, preventing the peptide aqueous solution from drying and crystallizing rapidly. This allows water-soluble small molecule peptides to remain in a dissolved state for a longer period of time, continuously diffusing into the epidermis along the concentration gradient, and significantly improving bioavailability.

[0036] At the same time, the biomimetic lipid components (lanolin, olive oil, beeswax) in the matrix mimic the lipid composition (ceramide, cholesterol, free fatty acids) in the stratum corneum of healthy skin, synergistically repairing the damaged skin barrier, reducing transepidermal water loss (TEWL), and exerting anti-inflammatory and antioxidant effects, creating a healthy skin foundation for the anti-aging effects of Cordyceps militaris small molecule peptides in signal-regulating collagen synthesis.

[0037] Compared with the prior art, the present invention has the following beneficial effects:

[0038] This invention actively promotes the transdermal absorption of hydrophilic Cordyceps militaris small molecule peptides through the synergistic effect of four strategies: water-in-oil emulsion system, hair follicle bypass opening, enhanced stratum corneum hydration, and continuous surface hydration. This overcomes the technical challenge of water-soluble active ingredients being unable to penetrate the lipid bilayer of the stratum corneum.

[0039] The matrix system of this invention not only serves as a peptide delivery carrier, but its biomimetic lipid components (lanolin, olive oil, beeswax) also possess the effects of repairing the skin barrier and reducing inflammation. The matrix physically facilitates the transdermal absorption of peptides, while the peptides exert an anti-aging effect by signal-regulating collagen synthesis; the two work synergistically.

[0040] Human efficacy testing has verified that, after 7 days of using the skin cream of this invention:

[0041] Skin moisture content significantly increased from 36.7% to 43.56% (P<0.05), an increase of 18.7%;

[0042] Skin elasticity increased from 52.38% to 53.96%;

[0043] Under ultraviolet radiation, the deep pigmentation of the skin decreased from 58.04% to 55%, a reduction of 5.2%.

[0044] No adverse reactions such as allergies, itching, or redness were observed in any of the participants.

[0045] According to the QB / T 1857-2013 "Skin Cream" standard, this product meets the standard requirements in terms of sensory indicators, physicochemical indicators, and hygiene indicators, as tested by a third-party testing agency.

[0046] The preparation method of this invention has mild process conditions, is easy to operate, requires no complicated equipment, and is suitable for large-scale production. Attached Figure Description

[0047] The accompanying drawings, which are incorporated in and form part of this specification, illustrate embodiments consistent with the invention and, together with the description, serve to explain the principles of the invention.

[0048] Figure 1 Human efficacy test results of the Cordyceps militaris small molecule peptide skin cream prepared in Example 1 of the present invention: bar chart of skin moisture content change (before use vs. after 7 days of use).

[0049] Figure 2 Human efficacy test results of the Cordyceps militaris small molecule peptide skin cream prepared for Example 1 of the present invention: bar chart of skin elasticity change (before use vs. after 7 days of use).

[0050] Figure 3Human efficacy test results of the Cordyceps militaris small molecule peptide skin cream prepared in Example 1 of the present invention: bar chart of skin oil content change (before use vs. after 7 days of use). Detailed Implementation

[0051] The present invention will be further described in detail below through specific embodiments and comparative examples. The following embodiments are for illustrative purposes only and should not be considered as limiting the scope of the invention.

[0052] Example 1

[0053] Weigh out each component according to the following formula (total volume approximately 200ml):

[0054] 12g of beeswax

[0055] 12g of lanolin

[0056] Petrolatum (white petrolatum) 28g

[0057] Cetyl alcohol 15g

[0058] Mineral oil (liquid paraffin) 60ml

[0059] 5ml olive oil

[0060] Sorbitan oleate (Span 80) 4ml

[0061] Phenoxyethanol 1.0ml

[0062] 65ml of deionized water

[0063] Lavender essential oil 1.5% (by total weight of the matrix)

[0064] Cordyceps militaris small molecule peptide powder 2.8% (as a percentage of total matrix weight)

[0065] The Cordyceps militaris small molecule peptide powder used in this embodiment can be prepared using methods known in the art. As a preferred embodiment, the Cordyceps militaris small molecule peptide powder can be prepared using the method disclosed in the applicant's patent application filed on the same day or earlier (application 202610284637.0).

[0066] (1) According to the above formula, weigh out beeswax, lanolin, petrolatum, cetyl alcohol, mineral oil, olive oil and sorbitan oleate and place them in a beaker. Heat to 80°C and stir until completely melted and mixed evenly to obtain the oil phase;

[0067] (2) Heat the deionized water to 80°C;

[0068] (3) Under stirring conditions (1000 rpm), the aqueous phase is slowly added to the oil phase, the temperature is kept at 80°C, and the mixture is continuously stirred and emulsified for 20 minutes. Then, the mixture is homogenized at 10000 rpm for 5 minutes using a high-speed homogenizer to form a water-in-oil emulsion matrix.

[0069] (4) Cool the emulsion system to 45°C, add lavender essential oil, Cordyceps militaris small molecule peptide powder and phenoxyethanol, and stir evenly;

[0070] (5) Continue stirring until room temperature to obtain the Cordyceps militaris small molecule peptide skin cream.

[0071] Example 2

[0072] The only difference between this embodiment and Example 1 is the formula ratio:

[0073] 10g of beeswax

[0074] 14g of lanolin

[0075] Petrolatum (white petrolatum) 24g

[0076] Cetyl alcohol 18g

[0077] Mineral oil (liquid paraffin) 55ml

[0078] 6ml olive oil

[0079] Sorbitan oleate (Span 80) 3ml

[0080] Phenoxyethanol 1.2ml

[0081] 70ml of deionized water

[0082] Lavender essential oil 1.0% (by total weight of the matrix)

[0083] Cordyceps militaris small molecule peptide powder 3.0% (as a percentage of total matrix weight)

[0084] The preparation method is the same as in Example 1.

[0085] Example 3:

[0086] The only difference between this embodiment and Example 1 is the formula ratio:

[0087] 14g of beeswax

[0088] 10g of lanolin

[0089] Petrolatum (white petrolatum) 32g

[0090] Cetyl alcohol 12g

[0091] Mineral oil (liquid paraffin) 65ml

[0092] 4ml olive oil

[0093] Sorbitan oleate (Span 80) 5ml

[0094] Phenoxyethanol 0.8ml

[0095] 60ml of deionized water

[0096] Lavender essential oil 1.0% (by total weight of the matrix)

[0097] Cordyceps militaris small molecule peptide powder 2.5% (by total matrix weight)

[0098] The preparation method is the same as in Example 1.

[0099] Comparative Example 1

[0100] The difference between this comparative example and Example 1 is that Cordyceps militaris small molecule peptide powder is not added, while the rest of the formula and preparation method are the same.

[0101] Comparative Example 1, without the addition of Cordyceps militaris small molecule peptide powder, lacked the core active signal regulating ingredient in its skin cream. Cordyceps militaris small molecule peptides are the key active ingredients in this invention for achieving anti-photoaging, promoting collagen synthesis, and inhibiting the expression of matrix metalloproteinases (MMP-1, MMP-3). Without the addition of peptide powder, the product's efficacy in promoting collagen synthesis, inhibiting MMP expression, and improving deep skin structure was significantly reduced compared to Example 1, thus proving that Cordyceps militaris small molecule peptide powder is one of the core sources of efficacy in this invention.

[0102] Comparative Example 2

[0103] The difference between this comparative example and Example 1 is that lavender essential oil is not added, but the rest of the formula and preparation method are the same.

[0104] Comparative Example 2 did not contain lavender essential oil, thus lacking a penetration-enhancing component that alters the permeability of the stratum corneum barrier. Terpenes such as linalool and linalyl acetate in lavender essential oil can interfere with the dense arrangement of lipids in the stratum corneum, altering the permeability of the stratum corneum barrier and thereby promoting the penetration of water-soluble Cordyceps militaris small molecule peptides along the skin appendage pathway. Without the addition of lavender essential oil, the transdermal absorption efficiency of the product was significantly lower than in Example 1, leading to a decrease in efficacy indicators such as the rate of increase in water content and elasticity. This demonstrates that lavender essential oil in this invention not only acts as a fragrance agent but also plays a crucial synergistic role in promoting penetration.

[0105] Comparative Example 3

[0106] The difference between this comparative example and Example 1 is that an oil-in-water (O / W) emulsion system (using Tween 80 as an emulsifier) ​​is used instead of an oil-in-water system, while the rest of the formulation and preparation method are the same.

[0107] Comparative Example 3 uses an oil-in-water emulsion system instead of an oil-in-water system. In an oil-in-water system, water is the continuous phase, and the water-soluble Cordyceps militaris small molecule peptides dissolve in the outer aqueous phase. After application, the peptide solution is directly exposed to the skin surface, lacking the protective and sustained-release effect of the oil phase on the hydrophilic active ingredients. Furthermore, it cannot utilize the "first moisturize, then replenish" gradient moisturizing mechanism of the oil-in-water system to promote transdermal absorption. In contrast, the oil-in-water system of this invention encapsulates the water-soluble peptides in the inner aqueous phase, achieving controlled-release delivery through the fusion of the oil phase with skin lipids. The transdermal absorption efficiency and moisturizing and firming effects of Comparative Example 3 are significantly lower than those of Example 1, thus demonstrating that the oil-in-water system is a key dosage form characteristic for achieving the technical effects of this invention.

[0108] Comparative Examples 1-3 are compared with Example 1 from three dimensions: "lack of active ingredient (peptide powder)," "lack of penetration-enhancing ingredient (lavender essential oil)," and "change in dosage form (oil-in-water instead of water-in-oil)." Changes in any of these dimensions lead to a significant decrease in product efficacy, thus demonstrating a synergistic relationship between the elements in the technical solution of this invention, and that the overall technical effect is superior to the simple summation of the individual elements.

[0109] To verify the actual application effect of the skin cream described in this invention, the following efficacy tests were conducted.

[0110] In accordance with the requirements of the "Evaluation Standards for Cosmetic Efficacy Claims," ​​a self-controlled before-and-after design was used to evaluate the moisturizing, repairing, and firming effects on facial and hand skin, and third-party testing was conducted to assess product safety. Specific test content and results are as follows.

[0111] Efficacy Test 1: Facial Skin Efficacy Test

[0112] Age distribution: Using a self-controlled before-and-after design, 30 healthy volunteers were recruited (6 men and 24 women, aged 20-59 years). Age distribution:

[0113]

[0114] Inclusion and Exclusion Criteria

[0115] Included: Healthy hand skin, no use of similar products in the past month.

[0116] Exclusion criteria: pregnancy, breastfeeding, skin diseases, history of cosmetic procedures or topical medications within the past 3 months.

[0117] Scientific basis for sample size: 30 participants meet the standards of the "Evaluation Specifications for Cosmetic Efficacy Claims" and the standard sample size for efficacy testing in the cosmetic industry, and can detect a moderate effect size (Cohen's d ≥ 0.5), possessing basic statistical significance. The male-to-female ratio of 1:4 takes into account gender differences and recruitment feasibility.

[0118] Test Design:

[0119] Cycle: 7 days / 14 days / 21 days / 28 days

[0120] Design type: Self-comparison before and after (each volunteer's own comparison).

[0121] Application method: Apply once in the morning and once in the evening, around 8:00 AM and 4:00 PM respectively. Group leaders are responsible for supervising their group members to complete the experiment.

[0122] Single dose: 0.5 grams (about the size of a soybean)

[0123] Daily dosage: 1 gram / person / day

[0124] Execution process:

[0125]

[0126] Note: "Test day before use" does not mean day 1; the first application will only begin that evening.

[0127] Test Design

[0128] Using a self-controlled before-and-after design, 30 healthy volunteers (6 males and 24 females, aged 20-59 years) were recruited. They used the skin cream prepared in Example 1, applying approximately 0.5g to their face twice a day, morning and evening, for 7 consecutive days. Skin hydration, skin elasticity, skin oil content, and several skin imaging indicators were measured before and after 7 days of use.

[0129] Inclusion criteria: Healthy facial skin, and no use of similar products in the past month. Exclusion criteria: Pregnant or breastfeeding women, individuals with skin diseases, and individuals who have received cosmetic treatments or used topical medications in the past 3 months.

[0130] Test Result Statistics

[0131] After using the skincare cream from Example 1 for 7 days, the test results are as follows:

[0132] 1) Skin moisture content:

[0133]

[0134] After 7 days of use, skin moisture content significantly increased from 36.7% to 43.56% (P < 0.05, paired t-test), an increase of 18.7%, indicating that the skin cream of this invention has significant moisturizing effects. Figure 1 As shown.

[0135] 2) Skin elasticity:

[0136]

[0137] After 7 days of use, skin elasticity increased from 52.38% to 53.96%, indicating that the skin cream of this invention has a certain firming and lifting effect (e.g., Figure 2 (As shown).

[0138] 3) Skin oil content:

[0139] Before use 49.12% — Use for 7 days 49.04% Basically stable

[0140] After 7 days of use, the skin's oil content decreased slightly from 49.12% to 49.04%, remaining basically stable. This indicates that the skin cream of this invention moisturizes without causing excessive sebum secretion, and has a good water-oil balance regulating effect (see...). Figure 3 ).

[0141] 4) Skin imaging indicators

[0142] Imaging analysis of the subjects' skin under normal light and ultraviolet light yielded the following results:

[0143] RGB pores decreased from 54% to 53.83%, RGB spots decreased from 71% to 70.74%, PL roughness increased from 61.57% to 61.78%, UV acne decreased from 62.23% to 60.83%, UV pigment decreased from 58.04% to 55% (a decrease of 5.24%), UV roughness decreased from 57% to 56.65%, and RGB texture remained basically unchanged.

[0144] Among them, UV pigment (deep hidden spots) decreased the most, reaching 5.24%, indicating that the skin cream of this invention has a positive effect on improving deep pigmentation of the skin; UV acne fluorescent spots decreased by 2.25%, indicating that the product helps regulate the metabolism of hair follicle sebum and reduce the risk of acne; PL roughness increased by 0.34%, indicating that the skin smoothness has been improved.

[0145] During the 7-day continuous use, none of the 30 subjects experienced any discomfort such as allergies, itching, redness, or stinging, indicating that the skin cream of this invention has good safety and skin tolerance.

[0146] Efficacy Test 2: Hand Skin Test

[0147] To verify the consistency of the product's efficacy on different skin areas, a hand skin test was also conducted.

[0148] Test Design

[0149] Ten healthy volunteers were selected, and test areas were marked on the inside of their arms. The skin cream prepared in Example 1 was applied twice daily for seven consecutive days. Skin moisture content was measured before and after use.

[0150] Test Results

[0151] Before use 38.17% — Use for 7 days 47.14% ↑23.5%

[0152] The results of the hand skin test and the facial skin test showed a consistent trend, further verifying that the skin cream of this invention has significant moisturizing effects on different skin areas.

[0153] The skin cream prepared in Example 1 was commissioned to a third-party testing agency for testing according to the QB / T 1857-2013 standard for "Skin Creams". The results are as follows:

[0154]

[0155] Test results: All tested items meet the requirements of QB / T 1857-2013 "Skin Moisturizing Creams".

[0156] This invention relates to a skin cream containing small molecule peptides from Cordyceps militaris that promotes transdermal absorption, and its preparation method. The raw materials are readily available, the preparation process is simple, and the conditions are mild, making it suitable for large-scale industrial production. The product has excellent moisturizing, repairing, firming, and skin-improving effects, and is safe and non-irritating. Tested by a third-party testing institution, it meets the requirements of QB / T 1857-2013 "Skin Creams" standard and can be widely used in the cosmetics field.

[0157] Although preferred embodiments of this application have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments as well as all changes and modifications falling within the scope of this application.

[0158] Obviously, those skilled in the art can make various modifications and variations to this application without departing from the spirit and scope of this application. Therefore, if such modifications and variations fall within the scope of the claims of this application and their equivalents, this application also intends to include such modifications and variations.

Claims

1. A skin cream containing small molecule peptides from Cordyceps militaris that promotes transdermal absorption, characterized in that, It is composed of a matrix component and an active component; the matrix component comprises, by weight, the following: Beeswax 10-14 parts, lanolin 10-14 parts, petrolatum 24-32 parts, cetyl alcohol 12-18 parts, mineral oil 55-65 parts, olive oil 4-6 parts, sorbitan oleate 80 3-5 parts, phenoxyethanol 0.8-1.2 parts, deionized water 60-70 parts; The active ingredients include: lavender essential oil and Cordyceps militaris small molecule peptide powder; The amount of Cordyceps militaris small molecule peptide powder added is 2.0%-3.5% of the total weight of the matrix.

2. The skin cream according to claim 1, characterized in that, The matrix components, by weight parts, are: 12 parts beeswax, 12 parts lanolin, 28 parts white petrolatum, 15 parts cetyl alcohol, 60 parts liquid paraffin, 5 parts olive oil, 4 parts Span 80, 1.0 part phenoxyethanol, 65 parts deionized water.

3. The skin cream according to claim 1, characterized in that, The amount of lavender essential oil added is 0.5%-1.0% of the total weight of the matrix.

4. The skin cream according to claim 1, characterized in that, The amount of Cordyceps militaris small molecule peptide powder added is 2.5%-3.0% of the total weight of the matrix.

5. The skin cream according to claim 1, characterized in that, The skin cream is an oil-in-water emulsion.

6. A method for preparing a skin cream containing small molecule peptides from Cordyceps militaris that promotes transdermal absorption, as described in any one of claims 1-5, characterized in that... Includes the following steps: (1) Weigh out the beeswax, lanolin, white petrolatum, cetyl alcohol, liquid paraffin, olive oil, and Span 80 according to the formula, mix them, heat to 75-85℃, stir until completely melted and mixed evenly to obtain the oil phase; (2) Heat the deionized water to 75-85℃; (3) Under stirring conditions, the aqueous phase is slowly added to the oil phase, the temperature is maintained at 75-85℃, and the mixture is continuously stirred and emulsified for 15-30 minutes to form a water-in-oil emulsion matrix; (4) Cool the emulsion system to 40-50℃, add lavender essential oil, Cordyceps militaris small molecule peptide powder and phenoxyethanol and stir evenly. (5) Continue stirring until room temperature to obtain the skin cream.

7. The preparation method according to claim 6, characterized in that, In step (3), a high-speed homogenizer is used for emulsification. The homogenization speed is 5000-15000 rpm and the homogenization time is 3-10 minutes.

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