Use of a composition for searching wind and resolving stasis in the preparation of a drug for treating cardiac structural damage caused by chronic intermittent hypoxia

Abstract

The application discloses a traditional Chinese medicine composition for treating heart structure damage caused by chronic intermittent hypoxia and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by mass: black soybean hull 20-40 parts, astragalus 20-40 parts, scorpion 0.5-1.5 parts and centipede 0.5-1.5 parts. The preparation method comprises the following steps: decocting the black soybean hull and the astragalus with water, filtering, grinding the scorpion and the centipede into powder, and then mixing the powder with the medicinal liquid to obtain the traditional Chinese medicine composition. Animal experiments show that the traditional Chinese medicine composition can significantly improve the heart structure damage caused by chronic intermittent hypoxia, including reducing the left atrial internal diameter, improving the left ventricular ejection fraction, improving the left ventricular end-diastolic volume, improving the pulmonary hypertension and the right ventricular systolic function, and reducing the incidence of atrial fibrillation and shortening the duration of atrial fibrillation. No serious toxic reaction occurs during the administration, and the safety is good. The application provides a safe and effective traditional Chinese medicine treatment scheme for the heart structure damage caused by chronic intermittent hypoxia, and is especially suitable for the drug intervention for the heart damage of people working at high altitudes and people suffering from obstructive sleep apnea syndrome.

Description

Technical Field

[0001] This invention belongs to the technical field of traditional Chinese medicine, and relates to the application of a wind-dispelling and nodule-resolving composition in the preparation of drugs for the prevention and treatment of cardiac structural damage caused by chronic intermittent hypoxia. Specifically, it relates to the application of a wind-dispelling and nodule-resolving composition, a wind-dispelling and nodule-resolving extract, and a wind-dispelling and nodule-resolving preparation in the preparation of drugs for the prevention and / or treatment of cardiac structural damage caused by chronic intermittent hypoxia. Background Technology

[0002] Chronic intermittent hypoxia (CIH) refers to a pathophysiological state in which the body repeatedly experiences alternating cycles of hypoxia and reoxygenation. It is one of the most insidious drivers of cardiac injury in clinical and specialized settings. Each dramatic fluctuation in blood oxygen saturation causes stress to cardiomyocytes, and long-term accumulation can lead to cardiomyocyte apoptosis, abnormal interstitial collagen deposition, pulmonary hypertension, right ventricular hypertrophy, myocardial fibrosis, cardiomyocyte apoptosis, and ventricular wall thickening, resulting in dual damage to both cardiac structure and function.

[0003] The clinical sources of chronic intermittent hypoxia are extremely diverse. Patients with obstructive sleep apnea syndrome (OSA) may experience dozens to hundreds of apneas per night, with their blood oxygen saturation repeatedly dropping below 80%. Furthermore, with the continuous advancement of infrastructure construction in my country's plateau regions, a large number of people from plains areas need to travel between plateaus and low altitudes for work activities, subjecting their bodies to typical CIH stimulation. Related surveys show that over 60% of plateau workers experience cardiac structural abnormalities during their work.

[0004] Currently, there are no effective clinical interventions for cardiac structural damage caused by chronic intermittent hypoxia. The first-line treatment for obstructive sleep apnea syndrome is continuous positive airway pressure (CPAP), but patient compliance is poor, and it is difficult to effectively reverse existing organic damage such as myocardial hypertrophy and fibrosis. Endothelin receptor antagonists and phosphodiesterase-5 inhibitors mainly act on pulmonary vessels, with limited direct protective effects on myocardial tissue; spironolactone, while having anti-myocardial fibrosis effects, has adverse reactions such as hyperkalemia. For people working at high altitudes, current treatment mainly relies on rest rotations and removal from hypoxic environments, with no effective pharmacological protective measures.

[0005] Chinese patent CN110123868B discloses a composition (Soufeng Sanjie Fang) for treating bone erosion in rheumatoid arthritis. However, the above patent only discloses the use of Soufeng Sanjie Fang in rheumatoid arthritis and does not involve its application in cardiac injury caused by chronic intermittent hypoxia.

[0006] It is worth noting that the inventors had previously discovered that the Soufeng Sanjie formula had a protective effect against cardiac damage caused by stress overload (Chinese Patent: CN122537431A). However, the pathological mechanisms of cardiac damage caused by stress overload and chronic intermittent hypoxia are completely different. The former is caused by mechanical stress overload, while the latter is driven by the hypoxia-reoxygenation cycle, involving multiple processes such as oxidative stress activation, inflammatory response, and extracellular mechanism remodeling. To date, there has been no basic research, clinical report, or patent literature at home and abroad that discloses the application of the Soufeng Sanjie formula in cardiac structural damage and atrial fibrillation caused by chronic intermittent hypoxia.

[0007] Current research still has many shortcomings: First, cardiac structural damage caused by chronic intermittent hypoxia lacks specificity and clinical intervention methods are limited; second, current research on TCM intervention for myocardial damage caused by chronic intermittent hypoxia mainly focuses on blood-activating and qi-tonifying compound formulas, and the application value of Soufeng Sanjie formula in this area has not yet been observed; third, although the cardiovascular protective effect of Soufeng Sanjie formula has shown some promise, the cardiac structural damage caused by chronic intermittent hypoxia is fundamentally different from the mechanical stress damage caused by pressure overload, and the application value of Soufeng Sanjie formula in this new indication remains completely blank. Summary of the Invention

[0008] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition for dispelling wind and resolving stagnation, a method for preparing its extract, a traditional Chinese medicine preparation containing the composition, and its novel pharmaceutical applications. This invention specifically targets the chain reaction of pulmonary vascular, right ventricular, left ventricular, and atrial electrical remodeling damage unique to chronic intermittent hypoxia, distinguishing it from the previously disclosed indications of pressure overload myocardial injury. Combined with qi-tonifying and root-strengthening herbs and insect-derived drugs to eliminate deep-seated toxins in the heart and lungs, it simultaneously improves pulmonary hypertension, right ventricular systolic function, left atrial dilation, left ventricular systolic and diastolic dysfunction, and significantly reduces the incidence of atrial fibrillation. Its efficacy is superior to the positive control drug spironolactone, with no significant toxic side effects from long-term administration. It is available in various dosage forms and can be used for the prevention and treatment of obstructive sleep apnea syndrome and cardiac injury and atrial fibrillation in individuals exposed to intermittent high-altitude hypoxia, filling a gap in existing technologies.

[0009] According to a first aspect of the present invention, a traditional Chinese medicine composition for treating myocardial structural damage caused by chronic intermittent hypoxia is provided, wherein the raw materials comprise, by weight, 20-40 parts of black soybean hulls, 20-40 parts of Astragalus membranaceus, 0.5-1.5 parts of scorpion, and 0.5-1.5 parts of centipede.

[0010] This invention posits that cardiac structural damage caused by chronic intermittent hypoxia falls under the categories of "palpitation," "chest pain," and "heart meridian obstruction" in Traditional Chinese Medicine (TCM). The core pathogenesis is fundamentally a deficiency of heart qi, with the superficial manifestations being blood stasis and toxins obstructing the meridians and damaging the heart meridians. This condition is characterized by a complex interplay of deficiency and excess, and a gradual worsening of symptoms. Chronic intermittent hypoxia is a periodic and recurring disturbance of pathogenic factors, continuously depleting the body's vital energy and heart qi, leading to abnormal ascending and descending of qi in the heart and lungs, heart qi deficiency, and insufficient blood circulation from the heart, failing to nourish the myocardium and blood vessels. Qi deficiency also affects the spleen and kidneys, further exacerbating the deficiency of vital energy and laying the fundamental foundation for the internal accumulation of blood stasis and toxins. Qi is the commander of blood; heart qi deficiency leads to sluggish and obstructed blood flow, gradually causing blood stasis in the fine myocardial meridians. This type of blood stasis, characterized by deficiency within stasis and deep-seated micro-meridians, differs from ordinary acute blood stasis and is difficult to eradicate using conventional blood-activating methods. The key characteristic of this disease lies in the chronic intermittent hypoxia, a unique cycle of repeated hypoxia-reoxygenation. This process induces a disruption of the body's Qi flow, leading to the accumulation of oxidative stress products and inflammatory factors. Stagnation transforms into fire and toxins, forming specific blood stasis toxins with both obstructive and damaging properties, which persistently linger in the heart vessels and erode the blood vessels. The heart vessels are delicate and intolerant to pathogenic invasion. Long-term damage from the cumulative effects of Qi deficiency, blood stasis, and blood stasis toxins can result in vessel contracture and rupture, and Qi and blood stagnation. This causes the intangible Qi stasis to gradually develop into tangible structural damage such as ventricular wall thickening, myocardial fibrosis, and cardiac chamber enlargement, forming a complete pathological change of "Qi deficiency - blood stasis - toxin accumulation - vessel damage - physical disability." Existing conventional prescriptions can only superficially improve Qi deficiency and blood stasis, failing to eliminate deep-seated accumulated blood stasis toxins, repair damaged heart vessels, and thus cannot stop the progressive damage process of this disease.

[0011] In this formula, black soybean skin, sweet and neutral in nature, enters the kidney and heart meridians, excelling at nourishing yin and benefiting the kidneys, nourishing blood and calming the heart, and moistening the collaterals. When the heart and kidneys interact, the heart qi naturally recovers, nourishing damaged myocardial collaterals and alleviating malnourishment of the heart collaterals caused by hypoxia stress. It can be combined with the principal herb to tonify qi and nourish yin, replenishing both qi and blood, strengthening the heart's fundamental source, and improving the myocardial deficiency and collateral malnourishment caused by chronic intermittent hypoxia. Astragalus, sweet and warm in nature, enters the heart, lung, and spleen meridians, greatly replenishing primordial qi, strengthening the defensive qi, consolidating the exterior, and promoting qi and blood circulation. Targeting the root cause of chronic intermittent hypoxia depleting primordial qi, qi deficiency leading to insufficient blood circulation and malnourishment of the heart collaterals, it strengthens the foundation, replenishes qi, and restores the heart's function of promoting blood circulation and unblocking the collaterals, fundamentally improving the underlying state of qi deficiency and blood stasis caused by hypoxia stress. Scorpion and centipede, both insect-based elixirs, have a penetrating and deep-penetrating medicinal property, excelling at dispelling wind, clearing the collaterals, breaking up stasis and dispersing nodules, and loosening collateral stagnation. Chronic intermittent hypoxia-induced myocardial injury is often due to prolonged illness and blood stasis, resulting in consolidation of the collaterals and stubborn stasis that is difficult to resolve. Ordinary herbal blood-activating drugs are insufficient to reach the delicate myocardial collaterals. The combined use of scorpion and centipede can penetrate deep into the delicate cardiac collaterals, searching out latent stasis, breaking up collateral knots, and clearing obstructed cardiac collaterals, thus treating stubborn pathological changes such as myocardial collateral stasis, collagen deposition, and structural remodeling caused by repeated stimulation from hypoxia and reoxygenation.

[0012] The raw materials for this invention are sourced as follows: Black soybean hull: The dried black seed coat of soybean (Glycine max (L.) Merr.) (leguminous family). Astragalus: The dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge., belonging to the legume family.

[0013] Centipede: The dried body of *Scolopendra subspinipes mutilans* L. Koch, an animal belonging to the genus *Scolopendra* of the family Scolopendraceae.

[0014] Whole scorpion: The dried body of Buthus martensii Karsch, an animal belonging to the genus Buthus in the family Scorpionidae.

[0015] In some embodiments, the raw material composition by weight includes: 30 parts black soybean hulls, 20 parts astragalus, 0.5 parts centipede, and 0.5 parts scorpion.

[0016] In some embodiments, the dosage form of the traditional Chinese medicine composition is an ointment, decoction, pill, granule, capsule, tablet, drop pill, oral liquid, injection, or powder. Therefore, the present invention can be administered via oral, injection, sublingual, rectal, transdermal, or aerosol inhalation routes to meet different medication needs. The dosage based on raw medicinal materials is 41-83 grams / day, and the specific dosage can be adjusted according to the patient's condition.

[0017] In some implementations, medically acceptable excipients may also be added.

[0018] According to a second aspect of the present invention, a method for preparing the above-mentioned traditional Chinese medicine composition is provided, wherein when the dosage form of the traditional Chinese medicine composition is a decoction, the preparation method includes the following steps: Weigh the raw materials according to the prescribed ratio. Add water to completely submerge the black bean husks and astragalus, ensuring the water level is 2-5 cm above the submerged area. Soak for 1-2 hours, then heat over high heat to a boil and maintain the boil for 15-35 minutes. After boiling, reduce heat to low and simmer for 20-40 minutes. Filter the decoction using a sieve with a mesh size ≤0.5mm. Grind the scorpion and centipede to obtain a clean powder, then sieve it through a sieve with a mesh size of at least 80 mesh. Add the sieved centipede and scorpion powder to the filtered decoction and mix to obtain the final decoction.

[0019] According to a third aspect of the present invention, the use of the above-described wind-dispelling and nodule-resolving traditional Chinese medicine composition in the preparation of a medicament for the prevention and / or treatment of cardiac structural damage caused by chronic intermittent hypoxia is provided.

[0020] (1) Animal experiments showed that the traditional Chinese medicine composition for dispelling wind and relieving stagnation could effectively improve cardiac function in rats induced by chronic intermittent hypoxia and improve the cardiac pathological changes in rats with chronic intermittent hypoxia. This suggests that the traditional Chinese medicine composition for dispelling wind and relieving stagnation has a therapeutic effect on cardiac structural damage caused by chronic intermittent hypoxia.

[0021] (2) The wind-dispelling and nodule-dispersing composition of the present invention can significantly improve the incidence of atrial fibrillation induced by chronic intermittent hypoxia in rats and shorten the duration of atrial fibrillation. No serious toxic reactions occurred during administration, and the safety profile is good. Attached Figure Description

[0022] Figure 1 The results of the effects of the Soufeng Sanjie formula on the left ventricular structure and function of CIH rats in animal experiments of this invention.

[0023] Figure 2 The results of the effects of the Soufeng Sanjie formula on pulmonary artery pressure and right ventricular function in CIH rats in animal experiments of this invention.

[0024] Figure 3 The results of the animal experiments of this invention on the effect of the Soufeng Sanjie formula on the duration and incidence of atrial fibrillation in CIH rats. Detailed Implementation

[0025] The present invention will be further described in detail below with reference to specific embodiments. It is worth noting that the following embodiments are only for better explaining the content of the present invention and do not limit the scope of protection of the present invention. Process steps not disclosed in the embodiments are prior art. Unless otherwise specified, all raw materials are commercially available. Example

[0026] The traditional Chinese medicine decoction for treating heart damage caused by chronic intermittent hypoxia in this embodiment consists of the following raw materials by weight: 30 parts black soybean husk, 20 parts astragalus, 0.5 parts centipede, and 0.5 parts scorpion.

[0027] Weigh the raw materials according to the specified ratio. Add water to completely submerge the black bean husks and astragalus, ensuring the water level is 5cm above the submerged area. Soak for 1.5 hours, then heat over high heat to a boil and maintain for 20 minutes. Reduce heat to low and simmer for 30 minutes. After simmering, filter using a sieve with a mesh size ≤0.5mm. Grind the scorpion and centipede to obtain a clean powder, then sieve using a sieve with a mesh size of at least 80 mesh. Add the sieved centipede and scorpion powder to the filtered medicinal liquid and mix.

[0028] In addition, other conventional methods for preparing traditional Chinese medicine decoctions can also be used to obtain the traditional Chinese medicine decoction of the present invention, which will not be listed here. Example

[0029] The traditional Chinese medicine decoction for treating heart damage caused by chronic intermittent hypoxia in this embodiment consists of the following ingredients by weight: 20 parts black soybean husk, 40 parts astragalus, 1.5 parts centipede, and 0.5 parts scorpion.

[0030] Its preparation method is the same as that of Example 1. Example

[0031] The traditional Chinese medicine decoction for treating heart damage caused by chronic intermittent hypoxia in this embodiment consists of the following raw materials by weight: 40 parts black soybean husk, 30 parts astragalus, 1 part centipede, and 1.5 parts scorpion.

[0032] Its preparation method is the same as that of Example 1. Example

[0033] The traditional Chinese medicine decoction for treating heart damage caused by chronic intermittent hypoxia in this embodiment consists of the following raw materials by weight: 30 parts black soybean husk, 20 parts astragalus, 1.5 parts centipede, and 1.5 parts scorpion.

[0034] Its preparation method is the same as that of Example 1. Example

[0035] The filtrate from Example 1 was concentrated and dried to obtain a dry extract. Starch, dextrin and other excipients were added, and the extract was granulated, dried and sized to obtain granules.

[0036] Below, a rat model of cardiac structural injury induced by chronic intermittent hypoxia is used to evaluate the therapeutic effect of the traditional Chinese medicine composition of the present invention (hereinafter referred to as Soufeng Sanjie Formula) on cardiac structural injury caused by chronic intermittent hypoxia.

[0037] 1. Laboratory animals Male SD rats, 3-4 weeks old, SPF grade, purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd.

[0038] 2. Experimental Methods (1) Animal grouping and intervention SD rats were randomly divided into 5 groups of 10 rats each: blank control group (NC), chronic intermittent hypoxia model group (CIH), positive drug group (spironolactone tablets, SPL), low-dose group of Soufeng Sanjie formula (SF-L), and high-dose group of Soufeng Sanjie formula (SF-H).

[0039] Chronic intermittent hypoxia-induced cardiac structural damage in rats was induced using an acrylic glass chamber: Rats were placed in an intermittent hypoxia chamber daily from 8:30 am to 4:30 pm, with alternating oxygen cycles of 5 minutes each, followed by 2 minutes of hypoxia (7% oxygen concentration) and 3 minutes of normoxic conditions (21% oxygen concentration). This cycle was repeated, with the chamber pressure maintained at atmospheric pressure.

[0040] The blank control group was continuously given normoxic oxygen at a concentration of 21%. All other groups were given chronic intermittent hypoxia treatment according to the modeling method described above. All groups were given normal food and water during non-experimental periods, and the total feeding time was 4 weeks.

[0041] The modeling and drug administration details for each group are as follows: NC: Normoalyptic rearing, with an equal amount of distilled water provided for 4 consecutive weeks.

[0042] CIH: 17 consecutive days of chronic intermittent hypoxia treatment, with distilled water administered for 4 weeks from the start of the hypoxia treatment.

[0043] SPL: 17 consecutive days of chronic intermittent hypoxia treatment, with 20 mg / kg spironolactone tablets administered for 4 weeks from the start of hypoxia treatment.

[0044] SF-L: 17 consecutive days of chronic intermittent hypoxia treatment, and 2.30 g / kg of low-dose Soufeng Sanjie formula was administered for 4 weeks from the start of hypoxia treatment.

[0045] SF-H: 17 consecutive days of chronic intermittent hypoxia treatment, and 4.59 g / kg of high-dose Soufeng Sanjie formula was administered for 4 weeks starting from the hypoxia treatment period.

[0046] All groups were given the medication once daily for 4 consecutive weeks.

[0047] (2) Detection of cardiac function impairment in rats: The cardiac function of rats was measured using an ultrasound imaging system. Specific methods: Rats were shaved on the chest, anesthetized with isoflurane, and then fixed in a supine position on a 37°C constant-temperature physiological platform. Anesthesia was maintained with a low dose of isoflurane. After anesthesia, the chest area of ​​the rats was shaved and coated with ultrasound coupling agent. The ultrasound probe sequentially acquired long-axis views of the left ventricle parasternally, four-chamber view of the heart at the apex, and short-axis views of the pulmonary artery and great artery. Cardiac structure, systolic and diastolic function of the left and right ventricles, and pulmonary blood flow-related parameters were detected. The detection was performed simultaneously in all groups of rats. See the experimental results for details. Figure 1 and Figure 2 . (3) Determination of the incidence of atrial fibrillation in rats: After anesthetizing rats, a pacing catheter was inserted into the right atrium of the anesthetized rats, and a sudden pacing at 20 Hz for 30 seconds at twice the threshold voltage was performed to trigger atrial fibrillation. Surface electrocardiograms and atrial electrocardiograms were recorded using an electrophysiological recorder, and the 2-minute atrial fibrillation incidence rate and time to onset were statistically analyzed. Detailed experimental results are available in [link to experimental results]. Figure 3 .

[0048] 3. Statistical methods Results are expressed as mean ± standard deviation (Mean ± SD.) and analyzed using Prism 10.1.2 software. Differences between groups were compared using one-way ANOVA (without assuming homogeneity of variance, Dunnett's T3). p < 0.05 was considered statistically significant.

[0049] 4. Results (1) Effects of Soufeng Sanjie Formula on the structure and function of the left heart in rats The effects of the Soufeng Sanjie formula on the left ventricular structure and function in rats subjected to chronic intermittent hypoxia are as follows: Figure 1 As shown in the figure, *** and **** represent P < 0.001, ** represents P < 0.01, and * represents P < 0.05. From Figure 1 As can be seen, compared with the NC group, the left atrial diameter (LA) of CIH rats was significantly increased (P<0.01), the left ventricular end-diastolic volume (LVVol;d) was decreased (P<0.001), and the left ventricular ejection fraction (LVEF) was decreased (P<0.001). This is because chronic intermittent hypoxia induces increased atrial load and atrial structural dilation; at the same time, myocardial contractile function is impaired, the left ventricular filling reserve capacity is reduced, and the overall cardiac pumping efficiency is decreased, gradually inducing cardiac atrioventricular remodeling and cardiac dysfunction. Compared with CIH, SF-L and SF-H can reduce the size of the left atrial diameter (P<0.01 and P<0.001), increase the left ventricular end-diastolic volume (P<0.05 and P<0.01), and SF-H can significantly reverse the decrease in left ventricular ejection fraction (P<0.05). Compared with the CIH group, the SPL group also reduced the left atrial diameter (P<0.01), but its effect on improving left ventricular end-diastolic volume and ejection fraction was not significant (P>0.05), suggesting that the Soufeng Sanjie formula is superior to the positive control drug in improving left ventricular diastolic function. This indicates that the traditional Chinese medicine composition of this invention can effectively improve the left ventricular structure and function in rats caused by chronic intermittent hypoxia.

[0050] (2) Effects of Soufeng Sanjie Formula on Pulmonary Circulation and Right Heart Function in Rats The effects of the Soufeng Sanjie formula on pulmonary circulation and right ventricle in rats subjected to chronic intermittent hypoxia are as follows: Figure 2 As shown in the figure, *** and **** represent P < 0.001, and ** represents P < 0.01. From Figure 2As can be seen, compared with the NC group, the pulmonary artery blood flow acceleration time (PAT) and tricuspid annular systolic displacement (TAPSE) of CIH rats were significantly reduced (P<0.001). This is because chronic intermittent hypoxia induces pulmonary hypertension and increased pulmonary vascular resistance, leading to excessive right ventricular afterload and ultimately impaired right ventricular systolic function. Compared with CIH, SF-L, SF-H, and SPL can all significantly reverse this reduction (P<0.05 and P<0.001). This indicates that the traditional Chinese medicine composition of this invention can effectively improve the changes in pulmonary circulation and right ventricular function in rats caused by chronic intermittent hypoxia.

[0051] (3) Effects of Soufeng Sanjie Formula on the incidence and timing of atrial fibrillation in rats The effects of the Soufeng Sanjie formula on the incidence and timing of atrial fibrillation in rats are as follows: Figure 3 As shown in the figure, the incidence of atrial fibrillation (AF) is 100% in the CIH group, 30% in the NC group, and 80% in the SPL and SF-L groups. However, the AF induction rate in the SF-H group is 50%, a decrease of 50 percentage points compared to CIH. Analysis of AF induction time revealed that the induction time for CIH was longer than that for NC, while the induction times for SPL and SF-H were shorter, especially for SF-H, where the induction times were shorter and more concentrated.

[0052] 5. Conclusion The traditional Chinese medicine composition of this invention can effectively improve the changes in cardiac pathological structure caused by chronic intermittent hypoxia, effectively reduce the incidence and duration of atrial fibrillation in rats, and effectively improve the pathological changes in rat cardiac tissue. This suggests that the wind-dispersing and nodule-resolving composition has a good therapeutic effect on cardiac injury in rats caused by chronic intermittent hypoxia.

[0053] The above embodiments are merely illustrative of the principles and effects of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or alter the above embodiments without departing from the spirit and scope of the present invention. Therefore, all equivalent modifications or alterations made by those skilled in the art without departing from the spirit and technical concept disclosed in the present invention should still be covered by the claims of the present invention.

Claims

1. Use of wind-dispelling and nodule-resolving compositions, extracts, or preparations in the preparation of medicaments for the prevention and / or treatment of cardiac structural damage caused by chronic intermittent hypoxia.

2. The use according to claim 1, characterized in that, The wind-dispelling and nodule-dispersing composition comprises, by weight, the following components: 20-40 parts black soybean husk; 20-40 parts astragalus; and 0.5-1.5 parts scorpion. Centipede 0.5-1.5 parts.

3. The use according to claim 1 or 2, characterized in that, The injuries include at least one of the following: pulmonary arteriole remodeling, pulmonary hypertension, right ventricular systolic dysfunction, left atrial pathological dilation, left ventricular diastolic filling restriction, left ventricular ejection fraction decrease, myocardial interstitial fibrosis, and atrial fibrillation.

4. The use according to claim 1 or 2, characterized in that, The intended use is manifested in at least one of the following functions: S1) Decrease the left atrial diameter (LA); S2) Increase left ventricular end-diastolic volume (LV Vol.d.); S3) Increases left ventricular ejection fraction (LVEF); S4) Prolong the pulmonary artery blood flow acceleration time (PAT); S5) Increased tricuspid annular systolic displacement (TAPSE); S6) Reduce the incidence of atrial fibrillation and shorten the duration of atrial fibrillation.

5. The use according to claim 1 or 2, characterized in that, The wind-dispelling and nodule-dispersing composition exists in the form of a wind-dispelling and nodule-dispersing extract. The preparation method of the extract includes: taking black soybean hulls and astragalus according to the ratio, soaking them in water, decocting them, filtering them, adding whole scorpion and centipede powder to the filtrate, mixing them well, and then obtaining the extract.

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