A ginseng composition for treating acne, a repair cream and a preparation method thereof

Abstract

The present application relates to the skin medical technical field, especially relate to a kind of ginseng composition for treating acne, repair paste and preparation method.A kind of ginseng composition for treating acne, including ginseng extract, andandrographis herb extract, leaf extract, vol.Boju extract, peony root extract, liquorice root extract and cypress leaf extract.A kind of repair paste, including ginseng composition.The repair paste prepared in the application has good anti-inflammatory, bacteriostatic and oil control effects, can effectively improve facial acne, relieve uncomfortable symptoms, reduce adverse reactions after treatment and acne recurrence rate.

Description

Technical Field

[0001] This invention relates to the field of skin medical technology, and in particular to a ginseng composition, repair cream and preparation method for treating acne. Background Technology

[0002] Acne, commonly known as pimples, is a common chronic inflammatory skin disease of the hair follicles and sebaceous glands. It is prevalent among adolescents, and the lesions are mostly distributed in areas rich in sebaceous glands such as the face, chest, and back. The clinical manifestations are mainly of various types, including comedones, papules, pustules, nodules, and cysts. Some patients may have pigmentation and scarring after healing, which not only has a long-term impact on the appearance of the patient's skin, but also easily causes negative psychological emotions such as anxiety and low self-esteem, reducing the patient's quality of life.

[0003] Currently, the main medications used clinically to treat acne include topical retinoids, antibiotics, and oral antibiotics and hormones. While these medications can achieve certain therapeutic effects, long-term use can easily lead to drug resistance and may cause adverse reactions such as skin irritation, endocrine disorders, and gastrointestinal discomfort. Some patients also experience a high recurrence rate after using these medications. Ginseng, as a traditional Chinese medicine, has multiple effects, including anti-inflammatory, immune-regulating, and skin microcirculation-improving properties. In recent years, it has been increasingly explored for use as an adjunct treatment for skin diseases. However, current topical ginseng compositions developed for acne still suffer from insufficient efficacy. Most only provide basic moisturizing and soothing effects, and their anti-inflammatory, antibacterial, and skin lesion-improving effects are not ideal, failing to meet the actual needs of clinical acne treatment. Summary of the Invention

[0004] To achieve a ginseng composition for treating acne with good anti-inflammatory and antibacterial effects, effectively improving acne lesions, relieving discomfort, and reducing adverse reactions and recurrence rates, this invention provides a ginseng composition, a repair ointment, and a preparation method for treating acne. The repair ointment prepared in this application has good anti-inflammatory, antibacterial, and oil-controlling effects, effectively improving facial acne, relieving discomfort, and reducing post-treatment adverse reactions and acne recurrence rates.

[0005] Firstly, the ginseng composition for treating acne provided in this application adopts the following technical solution:

[0006] A ginseng composition for treating acne, characterized in that, based on the mass fractions of the ginseng composition, it comprises 1-3 parts ginseng extract, 1-3 parts andrographis paniculata leaf extract, 0.05-0.1 parts canavalia gladiolus fruit extract, 0.05-0.1 parts papaya fruit extract, and 0.05-0.1 parts peony root extract.

[0007] In the above technical solution, ginseng extract is an active substance obtained from ginseng through extraction and processing. It contains various active ingredients such as ginsenosides, ginseng polysaccharides, and polypeptides, and has good anti-inflammatory and antioxidant effects. It can inhibit the release of inflammatory factors in acne sites, reduce local inflammatory reactions, regulate the local immune status of the skin, promote the repair of damaged dermal tissue, and reduce the probability of scar formation after acne healing. Combined with Andrographis paniculata leaf extract, it can synergistically enhance the antibacterial and anti-inflammatory effects, inhibiting the proliferation of pathogenic bacteria such as Propionibacterium acnes. Further combination with canavalia gladiata fruit extract, papaya fruit extract, and peony root extract can significantly improve the oil-controlling effect of the ginseng composition. The above-mentioned plant extracts, when combined, can work together from multiple perspectives—anti-inflammatory and antibacterial, regulating sebum secretion, and promoting skin lesion repair—to synergistically improve the treatment and conditioning effect on acne.

[0008] Preferably, the ginseng composition further includes licorice root extract, arborvitae leaf extract, loquat leaf extract and selaginella extract, comprising, by weight parts of 2-5 parts licorice root extract, 0.005-0.01 parts arborvitae leaf extract, 0.005-0.01 parts loquat leaf extract and 0.005-0.01 parts selaginella extract.

[0009] In the above technical solution, licorice root extract itself has anti-inflammatory and anti-allergic effects, which can further enhance the overall anti-inflammatory and antibacterial effect of the composition. At the same time, it can also soothe redness and discomfort caused by skin inflammation and reduce the possibility of other active ingredients irritating the skin. Platycladus orientalis leaf extract can help shrink skin pores and reduce sebum secretion. It also has a certain antibacterial effect and can help inhibit the proliferation of pathogenic bacteria in acne areas. Loquat leaf extract can clear heat and control oil, regulate sebaceous gland secretion, reduce oil accumulation at the hair follicle opening, and reduce the chance of acne formation. Selaginella tamariscina extract can help enhance the skin's repair ability, promote the regeneration of damaged epidermis, and accelerate the scab healing of acne lesions. After the combination of these ingredients, the conditioning and treatment effect of the composition on acne can be further enhanced, and the anti-inflammatory, oil-controlling, and repair-promoting effects can be synergistically improved.

[0010] Preferably, the ginseng composition further includes Hedyotis diffusa extract and Ophiopogon japonicus extract, comprising 0.05 to 0.1 parts of Hedyotis diffusa extract and 0.005 to 0.01 parts of Ophiopogon japonicus extract by mass fraction of the ginseng composition.

[0011] In the above technical solution, this application further adds Hedyotis diffusa extract and Ophiopogon japonicus extract to the ginseng composition. Hedyotis diffusa extract can further enhance the antibacterial and anti-inflammatory effects of the composition and inhibit the activity of Propionibacterium acnes. Ophiopogon japonicus extract can moisturize and soothe damaged skin, replenish the skin's required moisture, and relieve the dryness, tightness, and discomfort of the skin under inflammatory conditions. The combination of the two not only further enhances the conditioning effect of the composition on acne, but also significantly enhances the composition's inhibitory effect on capillary dilation, significantly reduces facial redness, and further reduces the production of post-inflammatory hyperpigmentation, improves the repair quality of damaged skin, and helps acne areas recover to a smooth and healthy state more quickly.

[0012] Secondly, the repair cream provided in this application adopts the following technical solution:

[0013] A repair cream, by weight percentage, comprises 0.2% to 1.5% ginseng composition, 9% to 17% emollient, 1% to 2.3% cooling agent, 1% to 5% skin conditioning agent, 8% to 18% emulsifier, 0.1% to 0.4% thickener, 0.5% to 1% penetrant, 0.1% to 0.5% antioxidant, 0.01% to 0.05% fragrance, 0.001% to 0.002% colorant, with the balance being solvent.

[0014] In the above technical solution, the ginseng composition is compounded into a repair cream base suitable for skin application. The emollient can form a moisturizing film on the skin surface, reducing skin moisture loss and relieving the dryness, tightness, and discomfort often associated with acne-prone skin. At the same time, it helps soften the stratum corneum, facilitating the penetration and absorption of active ingredients. The cooling agent can quickly improve the redness, swelling, heat, and pain caused by acne, providing a comfortable user experience. The skin conditioning agent can further synergize with the ginseng composition to exert anti-inflammatory, antibacterial, sebum-regulating, and skin barrier-repairing effects, jointly enhancing the improvement effect on acne. Other excipients such as emulsifiers and thickeners allow the repair cream to form a stable and uniform paste, making it convenient for storage and application. The penetrant helps the active ingredients better penetrate the stratum corneum and reach the lesion site to exert their effects, enhancing the overall conditioning efficacy.

[0015] Preferably, the emollient comprises ethylhexyl palmitate, mineral oil, white beeswax, and polydimethylsiloxane, comprising 5%~8% ethylhexyl palmitate, 3%~5% mineral oil, 1%~3% white beeswax, and 0.5%~1% polydimethylsiloxane by weight percentage of the repair cream.

[0016] In the above technical solution, this application selects a moisturizer with good spreadability and moderate moisturizing properties, which will not excessively increase the burden of skin oil and is suitable for use on acne-prone skin.

[0017] Preferably, the skin conditioning agent comprises salicylic acid, niacinamide, allantoin, dipotassium glycyrrhizate, β-glucan, and phytosterols, comprising, by weight percentage, 0.1%~0.5% salicylic acid, 0.1%~0.3% niacinamide, 0.1%~0.3% allantoin, 0.01%~0.02% dipotassium glycyrrhizate, 0.01%~0.02% β-glucan, and 1%~3% phytosterols.

[0018] In the above technical solution, salicylic acid can loosen the keratin and unclog the blocked hair follicle openings, niacinamide can reduce sebum secretion and improve abnormal keratinization of hair follicles, allantoin and dipotassium glycyrrhizate can soothe and reduce inflammation, β-glucan and phytosterols can help repair the damaged skin barrier, and work synergistically with ginseng to improve acne problems in multiple dimensions.

[0019] Preferably, the cooling agent includes menthol and borneol, comprising 1% to 2% menthol and 0.1% to 0.3% borneol by weight percentage of the repair ointment.

[0020] Preferably, the penetrant is laurocapram.

[0021] Thirdly, the preparation method of the repair cream provided in this application adopts the following technical solution:

[0022] A method for preparing a repair cream includes the following steps:

[0023] Step 1: Put the solvent into the emulsification pot, heat it to 80-85℃, add the flavoring agent and stir well;

[0024] Step 2: Mix the emollient, emulsifier, thickener and antioxidant and pour into the oil pan. While stirring, heat to 80-85℃ and then transfer to the emulsification pan to mix with the material obtained in Step 1.

[0025] Step 3: Homogenize the material obtained in Step 2, vacuum it, and then cool it to 42~48℃. Add the remaining raw materials, stir thoroughly, and you will get the repair cream.

[0026] Preferably, it includes the following steps:

[0027] Step 1: Put the solvent into the emulsification pot and start stirring (15-20 r / min). After heating the water to 80-85℃, add the fragrance and start homogenization (1800-2000 r / min) for 3-5 minutes while stirring (15-20 r / min) and keeping warm for 10-15 minutes.

[0028] Step 2: Weigh and mix the emollient, emulsifier, thickener, and antioxidant, then pour the mixture into an oil pan. While stirring (25-30 r / min), heat the mixture to 80-85℃, then transfer it to an emulsification pan and mix it with the material obtained in Step 1.

[0029] Step 3: Homogenize (2800-3000 r / min) for 5-10 min, then vacuum to (-0.05 MPa) and hold for 1-2 min before stopping. Then continue stirring (18-20 r / min) until the temperature drops to 42-48℃.

[0030] Step 4: Add the remaining raw materials one by one, stir thoroughly, homogenize (2800-3000r / min) for 4-5 minutes, and filter the material through a 100-mesh filter cloth.

[0031] In the above technical solution, this application uses a phased temperature-controlled processing method. First, the oil phase and water phase are mixed and emulsified at a high temperature to ensure the stability of the system. Then, ginseng composition and other heat-sensitive active ingredients are added at a lower temperature to reduce the damage of high temperature to the active ingredients and better preserve the efficacy of each active substance. The resulting repair cream has a delicate and uniform texture, good stability, and stable efficacy.

[0032] In summary, this application includes at least one of the following beneficial technical effects:

[0033] 1. This application obtains a ginseng composition by combining ginseng extract with a variety of natural plant extracts. The components work synergistically to exert effects from multiple angles, including anti-inflammatory and antibacterial properties, regulation of sebum secretion, soothing of discomfort, and promotion of skin lesion repair. It has a significant conditioning effect on acne and is less irritating than conventional topical medications for treating acne, making it more suitable for long-term use.

[0034] 2. By further adding Hedyotis diffusa extract and Ophiopogon japonicus extract to the ginseng composition, this application significantly enhances the inhibitory effect of the composition on capillary dilation, significantly reduces facial redness, further reduces the production of post-inflammatory hyperpigmentation, improves the repair quality of damaged skin, and helps acne areas recover to a smooth and healthy state more quickly.

[0035] 3. This application adds the above-mentioned ginseng composition to the repair cream base, and the resulting topical repair cream is suitable for acne patients to apply. It can be applied directly to the acne lesions and can quickly relieve the discomfort symptoms such as redness, swelling, pain and itching caused by acne. It can effectively reduce the range of lesions, promote the regression of acne, and reduce pigmentation and scar formation after acne heals. It can also reduce the probability of acne recurrence.

[0036] 4. The repair ointment of this application has a simple preparation process, and the efficacy of each active ingredient in the ginseng composition can be well preserved during the processing. The resulting repair ointment has good stability and stable efficacy, and is suitable for industrial production and application. Detailed Implementation

[0037] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0038] Example 1

[0039] A ginseng composition for treating acne comprises 0.175g of ginseng extract, 0.175g of andrographis paniculata leaf extract, 0.006g of canavalia gladiata fruit extract, 0.006g of papaya fruit extract and 0.009g of peony root extract.

[0040] Among them, the ginseng (PANAX GINSENG) extract is a water extract with an extraction ratio of 1:10, and was purchased from Quzhou Zhanhong Biotechnology Co., Ltd.

[0041] Among them, the Andrographis paniculata (ANDROGRAPHIS PANICULATA) leaf extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Guangzhou Nettech Biotechnology Co., Ltd.

[0042] Among them, the sword bean (CANAVALIA GLADIATA) fruit extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Xi'an Clover Biotechnology Co., Ltd.

[0043] Among them, the papaya (CARICA PAPAYA) fruit extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0044] Among them, the peony (PAEONIA SUFFRUTICOSA) root extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shanghai Ruidean Biotechnology Co., Ltd.

[0045] The preparation method of the ginseng composition for treating acne is as follows:

[0046] After weighing each ingredient according to the specified ratio, mix them thoroughly to obtain the ginseng composition.

[0047] Example 2

[0048] A ginseng composition for treating acne, differing from Example 1, comprises 0.1g ginseng extract, 0.3g andrographis paniculata leaf extract, 0.01g canavalia gladiata fruit extract, 0.005g papaya fruit extract, and 0.005g peony root extract.

[0049] Example 3

[0050] A ginseng composition for treating acne, differing from Example 1, comprises 0.3g ginseng extract, 0.1g andrographis paniculata leaf extract, 0.005g canavalia gladiata fruit extract, 0.01g papaya fruit extract, and 0.01g peony root extract.

[0051] Example 4

[0052] A ginseng composition for treating acne, differing from Example 1, comprises 0.175g ginseng extract, 0.175g andrographis paniculata leaf extract, 0.006g canavalia gladiolus fruit extract, 0.006g papaya fruit extract, 0.009g peony root extract, 0.27g licorice root extract, 0.0006g arborvitae leaf extract, 0.0006g loquat leaf extract, and 0.0006g selaginella extract.

[0053] The licorice (Glycyrrhiza uralensis) root extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shanghai Ruidean Biotechnology Co., Ltd.

[0054] Among them, the leaf extract of BIOTA ORIENTALIS is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shanghai Ruidean Biotechnology Co., Ltd.

[0055] Among them, the loquat (ERIOBOTRYA JAPONICA) leaf extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shanghai Ruidean Biotechnology Co., Ltd.

[0056] The extract of Selaginella tamariscina is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shanghai Ruidean Biotechnology Co., Ltd.

[0057] Example 5

[0058] A ginseng composition for treating acne, differing from Example 1, comprises 0.1g ginseng extract, 0.3g andrographis paniculata leaf extract, 0.01g canavalia gladiolus fruit extract, 0.005g papaya fruit extract, 0.005g peony root extract, 0.2g licorice root extract, 0.001g arborvitae leaf extract, 0.001g loquat leaf extract, and 0.001g selaginella extract.

[0059] Example 6

[0060] A ginseng composition for treating acne, differing from Example 1, comprises 0.3g ginseng extract, 0.1g andrographis paniculata leaf extract, 0.005g canavalia gladiolus fruit extract, 0.01g papaya fruit extract, 0.01g peony root extract, 0.5g licorice root extract, 0.0005g arborvitae leaf extract, 0.0005g loquat leaf extract, and 0.0005g selaginella extract.

[0061] Example 7

[0062] A ginseng composition for treating acne, differing from Example 1, comprises 0.175g ginseng extract, 0.175g andrographis paniculata leaf extract, 0.006g canavalia gladiolus fruit extract, 0.006g papaya fruit extract, 0.009g peony root extract, 0.27g licorice root extract, 0.0006g arborvitae leaf extract, 0.0006g loquat leaf extract, 0.0006g selaginella tamariscina extract, 0.08g Hedyotis diffusa extract, and 0.007g Ophiopogon japonicus extract.

[0063] Among them, the extract of Hedyotis diffusa is an aqueous extract with an extraction ratio of 1:10, and was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0064] Among them, the Ophiopogon japonicus (Ophiopogon japonicus) extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shaanxi Xintianyu Biotechnology Co., Ltd.

[0065] Example 8

[0066] A ginseng composition for treating acne, differing from Example 1, comprises 0.1g ginseng extract, 0.3g andrographis paniculata leaf extract, 0.01g canavalia gladiolus fruit extract, 0.005g papaya fruit extract, 0.005g peony root extract, 0.2g licorice root extract, 0.001g arborvitae leaf extract, 0.001g loquat leaf extract, 0.001g selaginella tamariscina extract, 0.1g oldenlandia diffusa extract, and 0.01g ophiopogon japonicus extract.

[0067] Example 9

[0068] A ginseng composition for treating acne, differing from Example 1, comprises 0.3g ginseng extract, 0.1g andrographis paniculata leaf extract, 0.005g canavalia gladiolus fruit extract, 0.01g papaya fruit extract, 0.01g peony root extract, 0.5g licorice root extract, 0.0005g arborvitae leaf extract, 0.0005g loquat leaf extract, 0.0005g selaginella tamariscina extract, 0.05g Hedyotis diffusa extract, and 0.005g Ophiopogon japonicus extract.

[0069] Example 10

[0070] A ginseng composition for treating acne, differing from Example 7 in that an equal amount of Hedyotis diffusa extract is replaced with Viola yedoensis extract.

[0071] Among them, the Viola yedoens extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0072] Example 11

[0073] A ginseng composition for treating acne, differing from Example 7 in that an equal amount of Ophiopogon japonicus extract is replaced with Polygonatum odoratum extract.

[0074] Among them, the Polygonatum odoratum extract is a water extract with an extraction ratio of 1:10, and was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0075] Comparative Example 1

[0076] A ginseng composition for treating acne, differing from Example 1 in that the canavalia fruit extract is replaced in equal amounts with forsythia extract.

[0077] Among them, the Forsythia suspensa extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shaanxi Junhe Biotechnology Co., Ltd.

[0078] Comparative Example 2

[0079] A ginseng composition for treating acne, differing from Example 1 in that papaya fruit extract is replaced in equal amounts with honeysuckle flower extract.

[0080] Among them, the honeysuckle (LONICERA JAPONICA) flower extract is an aqueous extract with an extraction ratio of 1:10, and was purchased from Lanzhou Waterles Biotechnology Co., Ltd.

[0081] Comparative Example 3

[0082] A ginseng composition for treating acne, differing from Example 1 in that an equal amount of peony root extract is replaced with Cynanchum paniculatum extract.

[0083] Among them, the extract of Cynanchum paniculatum is an aqueous extract with an extraction ratio of 1:10, and was purchased from Shandong Guante Biotechnology Co., Ltd.

[0084] Application Example 1

[0085] A repair cream comprising 55.0535g water, 1.4g ginseng composition, 5.3g propylene glycol, 4g ethanol, 0.3g butylene glycol, 0.05g glycerin, 6g ethylhexyl palmitate, 4g mineral oil, 2.5g beeswax, 1g dimethicone, 1g laurocapram, 1.3g palmitic acid, 0.7g stearic acid, 5.35g cetearyl alcohol, 2g cetearyl alcohol polyether-2, 2g cetearyl alcohol polyether-21, 1g glyceryl stearate, 0.6g lauric acid / myristic acid / palmitic acid / glyceryl stearate esters, and 0.35g PEG-1. 0.00 stearate, 0.15g PEG-20 stearate, 0.15g xanthan gum, 0.05g disodium EDTA, 2g menthol, 0.3g borneol, 0.5g salicylic acid, 0.2g nicotinamide, 0.2g allantoin, 0.015g dipotassium glycyrrhizate, 0.015g β-glucan, 2.125g phytosterols, 0.2g p-hydroxyacetophenone, 0.06g capryloyl hydroxamic acid, 0.045g phenoxyethanol, 0.04g glyceryl caprylate, 0.005g ethylhexylglycerin, 0.04g fragrance, 0.0015g CI 19140.

[0086] The ginseng composition was prepared by the method described in Example 1.

[0087] The menthol was purchased from Zhengzhou Jiuting Chemical Products Co., Ltd.

[0088] The borneol was purchased from Xi'an Jiatian Biotechnology Co., Ltd.

[0089] Among them, laurocapram was purchased from Greenlink (Jining) Chemical Technology Co., Ltd.

[0090] The preparation method of the repair cream includes the following steps:

[0091] Step 1: Put the solvent into the emulsification pot, stir at 18 r / min, heat the water to 82℃, add the fragrance, homogenize at 1900 r / min for 4 min, and keep warm for 12 min while stirring at 18 r / min.

[0092] Step 2: Weigh and mix the emollient, emulsifier, thickener, and antioxidant, then pour the mixture into an oil pan. While stirring at 28 rpm, heat the mixture to 82°C, then transfer it to an emulsification pan and mix it with the material obtained in Step 1.

[0093] Step 3: Homogenize at 2900 r / min for 8 min, then vacuum to -0.05 MPa and hold for 1-2 min before stopping. Then continue stirring at 19 r / min until the temperature drops to 45℃.

[0094] Step 4: Add the remaining raw materials in sequence, stir thoroughly, homogenize at 2900 r / min for 4 min, and filter the material through a 100 mesh filter cloth.

[0095] Application Example 2

[0096] A repair cream, differing from Application Example 1, comprises 56.734g water, 0.8g ginseng composition, 5g propylene glycol, 5g ethanol, 0.2g butylene glycol, 0.1g glycerin, 5g ethylhexyl palmitate, 5g mineral oil, 1g white beeswax, 1g polydimethylsiloxane, 1g laurocapram, 2g palmitic acid, 0.5g stearic acid, 4g cetearyl alcohol, 3g cetearyl alcohol polyether-2, 1g cetearyl alcohol polyether-21, 1g glyceryl stearate, 1g lauric acid / myristic acid / palmitic acid / glyceryl stearate esters, and 0.1g PE. G-100 stearate, 0.3g PEG-20 stearate, 0.3g xanthan gum, 0.01g disodium EDTA, 2g menthol, 0.1g borneol, 0.2g salicylic acid, 0.1g nicotinamide, 0.3g allantoin, 0.02g dipotassium glycyrrhizate, 0.01g β-glucan, 3g phytosterols, 0.1g p-hydroxyacetophenone, 0.03g capryloyl hydroxamic acid, 0.03g phenoxyethanol, 0.05g glyceryl caprylate, 0.005g ethylhexylglycerin, 0.01g fragrance, 0.001g CI 19140.

[0097] The ginseng composition was prepared by the method described in Example 2.

[0098] The preparation method of the repair cream includes the following steps:

[0099] Step 1: Put the solvent into the emulsification pot, stir at 15 r / min, heat the water to 80℃, add the fragrance, homogenize at 1800 r / min for 5 min, and keep warm for 15 min while stirring at 15 r / min.

[0100] Step 2: Weigh and mix the emollient, emulsifier, thickener, and antioxidant, then pour the mixture into an oil pan. While stirring at 25 rpm, heat the mixture to 85°C, then transfer it to an emulsification pan and mix it with the material obtained in Step 1.

[0101] Step 3: Homogenize at 2800 r / min for 10 min, then vacuum to -0.05 MPa and hold for 2 min before stopping. Continue stirring at 18 r / min until the temperature drops to 48℃.

[0102] Step 4: Stir the remaining raw materials thoroughly, homogenize at 2800 rpm for 5 minutes, and filter the material through a 100-mesh filter cloth.

[0103] Application Example 3

[0104] A repair cream, differing from Application Example 1, comprises 56.477g water, 2g ginseng composition, 6g propylene glycol, 3g ethanol, 0.5g butylene glycol, 0.05g glycerin, 8g ethylhexyl palmitate, 3g mineral oil, 3g white beeswax, 0.5g polydimethylsiloxane, 0.5g lauryl diazoline, 1g palmitic acid, 1g stearic acid, 6g cetearyl alcohol, 1g cetearyl alcohol polyether-2, 3g cetearyl alcohol polyether-21, 0.5g glyceryl stearate, 0.5g lauric acid / myristic acid / palmitic acid / glyceryl stearate esters, 0.5g... 0.1g PEG-100 stearate, 0.1g PEG-20 stearate, 0.1g xanthan gum, 0.05g disodium EDTA, 1g menthol, 0.2g borneol, 0.1g salicylic acid, 0.3g nicotinamide, 0.1g allantoin, 0.01g dipotassium glycyrrhizate, 0.02g β-glucan, 1g phytosterols, 0.3g p-hydroxyacetophenone, 0.08g capryloyl hydroxamic acid, 0.05g phenoxyethanol, 0.01g glyceryl caprylate, 0.001g ethylhexylglycerin, 0.05g fragrance, 0.002g CI 19 140.

[0105] The ginseng composition was prepared by the method described in Example 3.

[0106] The preparation method of the repair cream includes the following steps:

[0107] Step 1: Put the solvent into the emulsification pot, stir at 20 r / min, heat the water to 80℃, add the fragrance, homogenize at 2000 r / min for 3 min, and keep warm for 10 min while stirring at 20 r / min.

[0108] Step 2: Weigh and mix the emollient, emulsifier, thickener, and antioxidant, then pour the mixture into an oil pan. While stirring at 30 rpm, heat the mixture to 80°C, then transfer it to an emulsification pan and mix it with the material obtained in Step 1.

[0109] Step 3: Homogenize at 3000 r / min for 5 min, then vacuum to -0.05 MPa and hold for 1 min before stopping. Continue stirring at 20 r / min until the temperature drops to 42℃.

[0110] Step 4: Add the remaining raw materials in sequence, stir thoroughly, homogenize at 23000r / min for 4min, and filter the material through a 100-mesh filter cloth.

[0111] Application Example 4

[0112] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 4.

[0113] Application Example 5

[0114] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 5.

[0115] Application Example 6

[0116] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 6.

[0117] Application Example 7

[0118] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 7.

[0119] Application Example 8

[0120] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 8.

[0121] Application Example 9

[0122] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 9.

[0123] Application Example 10

[0124] A repair ointment, unlike Application Example 1, is prepared using the ginseng composition prepared by the method of Example 10.

[0125] Application Example 11

[0126] A repair ointment, unlike Application Example 1, is prepared using a ginseng composition prepared by the method of Example 11.

[0127] Comparative Application Example 1

[0128] A repair cream, unlike Application Example 1, is prepared by the preparation method of Comparative Example 1.

[0129] Comparative Application Example 2

[0130] A repair ointment, unlike Application Example 1, is prepared using the preparation method of Comparative Example 2.

[0131] Comparative Application Example 3

[0132] A repair ointment, unlike Application Example 1, is prepared using the preparation method of Comparative Example 3.

[0133] Efficacy verification

[0134] 1. The effects of the ginseng compositions in the above embodiments and comparative examples on lipid secretion in human sebaceous gland cells.

[0135] Human sebaceous gland cells in logarithmic growth phase (Shanghai Aiyan Biotechnology Co., Ltd.) were used at a rate of 1*10 4 Cells were seeded per well in 96-well plates and cultured at 37°C with 5% CO2 for 24 h. After aspirating the culture medium, the cells were divided into a blank group, a control group, and an experimental group, with 5 replicates in each group. The blank group contained no cells and was cultured in DMEM high-glucose medium (Shanghai Huayasichuang Biotechnology Co., Ltd.). The control group was cultured in DMEM high-glucose medium, and the experimental group was cultured in DMEM high-glucose medium containing 2% ginseng composition. Cultures were continued for another 24 h. After culture, CCK-8 solution (CCK-8 kit, Shanghai Beibo Biotechnology Co., Ltd.) was added, and the cells were incubated at 37°C for 2 h. The absorbance of each well was measured at 450 nm, and cell viability was calculated. Cell viability (%) = (experimental group - blank group) / (control group - blank group) * 100%. The experimental results were averaged and detailed in Table 1.

[0136] Human sebaceous gland cells in the logarithmic growth phase were divided into 1*10 4 Each well was inoculated with one sample of 96-well Nile Red (NIL) and incubated at 37°C with 5% CO2 for 24 h. After aspirating the culture medium, the plates were divided into a control group and an experimental group, with 5 replicates in each group. The control group was inoculated with DMEM high-glucose medium, while the experimental group was inoculated with DMEM high-glucose medium containing 2% ginseng composition. The plates were incubated for another 24 h. After incubation, the plates were stained with 10 g / mL Nile Red (Sigma-Aldrich, USA) and 15 g / mL fluorescein diacetate (Sigma-Aldrich, USA) diluted in PBS, and incubated at 37°C for 10 min in the dark. After washing twice with PBS, the fluorescence intensity of Nile Red (excitation wavelength 485 nm / emission wavelength 565 nm) and fluorescein diacetate (excitation wavelength 494 nm / emission wavelength 523 nm) was measured using a multi-functional microplate reader. The results were expressed as the ratio of Nile Red to fluorescein fluorescence intensity. The lipid synthesis rate was calculated as: Lipid synthesis rate (%) = (Experimental group / Control group) * 100%. The experimental results are averaged, as detailed in Table 1.

[0137] Table 1:

[0138] Example 1 104.27 42.19 Example 2 104.15 43.67 Example 3 104.07 43.12 Example 4 104.82 39.84 Example 5 104.69 41.48 Example 6 104.41 40.83 Example 7 105.24 34.31 Example 8 105.51 35.23 Example 9 105.03 34.94 Example 10 104.76 37.68 Example 11 104.97 36.65 Comparative Example 1 103.43 81.34 Comparative Example 2 104.01 74.12 Comparative Example 3 103.62 66.94

[0139] Based on the analysis of Examples 1-11, Comparative Examples 1-3, and Table 1, it can be seen that the ginseng composition provided in this application does not have an adverse effect on the vitality of human sebaceous gland cells, and the cell vitality remains above 100%, indicating that the ginseng composition is mild and has no obvious cytotoxicity. At the same time, the ginseng compositions prepared in each embodiment of this application can significantly inhibit lipid synthesis in human sebaceous gland cells, indicating that the ginseng compositions in the embodiments of this application can effectively reduce the lipid secretion level of sebaceous gland cells, thereby reducing the oily basis for acne formation from the source.

[0140] Specifically, based on the analysis of Example 1 and Comparative Examples 1-3, it can be seen that Comparative Example 1 replaced the canavalia fruit extract, Comparative Example 2 replaced the papaya fruit extract, and Comparative Example 3 replaced the peony root extract. Example 1 showed a significant inhibitory effect on lipid synthesis, indicating that the combination of canavalia fruit extract, peony root extract, and papaya fruit extract with ginseng extract and andrographis paniculata leaf extract produced an unexpected synergistic effect, which together achieved a good effect of inhibiting sebaceous gland lipid secretion. Replacing or lacking any one of the components would lead to a significant decrease in the effect.

[0141] 2. The impact of the repair creams in the above application examples and comparative application examples on acne treatment.

[0142] This study included 140 patients with acne vulgaris, aged 18-40 years, with no gender restrictions. They had not received treatment or used any acne-related medications in the past 3 months. According to the "Chinese Guidelines for the Treatment of Acne (2019 Revised Edition)," they were classified as having mild to moderate acne. Mild acne was defined as having scattered to multiple comedones, with a small number of papules and pustules, and a total of less than 30 lesions. Moderate acne was defined as having comedones, a moderate number of papules and pustules, and a total of 31-50 lesions.

[0143] The participants were randomly divided into 14 groups of 10 people each. They used the external repair cream twice a day, morning and evening, for 12 consecutive weeks.

[0144] On days 0 and 28 of treatment, transepidermal water loss (TEWL), stratum corneum moisture content, and skin lipid content were measured using an MPA4 multifunctional skin analyzer (CK, Germany). The area of ​​the red zone and porphyrin levels on the face were measured and recorded using a CBS cloud-lens multispectral facial device. The results were averaged for each group; see Table 2 for details.

[0145] On day 28 of treatment, a dermatologist evaluated the treatment efficacy based on the reduction rate of lesions. The criteria for efficacy were: cured: ≥90% reduction in the number of lesions; significantly effective: 60%~89% reduction in the number of lesions; effective: 20%~59% reduction in the number of lesions; ineffective: <20% reduction in the number of lesions.

[0146] Calculate the overall effective rate for each group. Overall effective rate = (number of cured cases + number of cases with significant effect + number of effective cases) / total number of cases in each group × 100%. See Table 2 for the statistical results.

[0147] A questionnaire survey was conducted on acne patients 12 weeks after treatment. Satisfaction was assessed on three dimensions: recurrence, erythema in the lesion area, and pigmentation. The total score ranged from 0 to 100. Very satisfied: ≥90 points; Satisfied: 75 to <90 points; Average: 55 to <75 points; Dissatisfied: 35 to <55 points; Very dissatisfied: <35 points. The statistical results were averaged for each group, as detailed in Table 3.

[0148] Table 2:

[0149] Application Example 1 18.76 11.21 51.94 61.62 62.38 41.98 1829.76 1093.79 527.64 217.84 100 Application Example 2 18.59 11.32 52.21 60.31 62.76 43.43 1795.29 1093.56 513.92 214.96 100 Application Example 3 18.25 11.26 51.78 58.73 62.51 42.28 1729.53 1067.16 524.47 221.34 100 Application Example 4 19.21 10.49 52.04 70.02 62.83 39.42 1830.46 1056.83 528.2 204.63 100 Application Example 5 18.73 10.53 51.95 67.12 62.49 40.54 1819.21 1083.79 560.61 221.82 100 Application Example 6 18.46 10.17 51.73 68.69 62.52 39.64 1854.73 1081.93 554.03 216.15 100 Application Example 7 19.12 9.93 52.16 75.08 63.14 39.03 1782.61 877.01 528.75 197.68 100 Application Example 8 18.94 10.04 51.83 73.51 62.67 38.94 1820.93 949.57 478.49 180.32 100 Application Example 9 19.27 10.13 52.31 74.02 62.34 38.86 1837.25 922.52 521.34 196.71 100 Application Example 10 18.92 10.31 51.96 70.05 62.18 38.92 1732.42 969.26 508.26 196.73 100 Application Example 11 18.68 10.15 52.14 70.61 62.05 39.19 1902.19 1072.21 549.78 212.31 100 Comparative Application Example 1 18.71 13.74 51.82 45.38 61.96 60.45 1893.62 1390.12 573.18 285.02 60 Comparative Application Example 2 19.23 13.63 52.08 48.16 63.21 58.85 1742.38 1234.67 534.64 259.53 60 Comparative Application Example 3 18.86 12.87 51.72 50.64 62.58 55.46 1702.35 1161.52 498.31 232.41 70

[0150] Table 3:

[0151] Application Example 1 87 76 74 Application Example 2 81 70 70 Application Example 3 84 73 71 Application Example 4 86 81 82 Application Example 5 90 79 78 Application Example 6 93 82 81 Application Example 7 99 98 99 Application Example 8 96 94 97 Application Example 9 97 96 97 Application Example 10 94 84 83 Application Example 11 93 85 85 Comparative Application Example 1 68 63 62 Comparative Application Example 2 73 64 65 Comparative Application Example 3 79 71 67

[0152] Based on the analysis of Application Examples 1-11, Comparative Application Examples 1-3, and Table 2, it can be seen that the repair cream prepared in this application showed a significant decrease in transepidermal water loss and a significant increase in stratum corneum moisture content on day 28 compared to the initial treatment stage. This indicates that the repair cream provided by this application can effectively improve the damaged skin barrier of acne patients, reduce skin moisture loss, and enhance the skin's water-locking ability. At the same time, the skin lipid content, the area of ​​facial redness, and the porphyrin value were all significantly reduced compared to the initial treatment stage, indicating that the repair cream of this application can effectively regulate skin sebum secretion, reduce inflammatory redness caused by acne, inhibit the proliferation of pathogenic microorganisms such as Propionibacterium acnes, thereby reducing the number of acne lesions and effectively improving facial acne.

[0153] Further analysis of patient satisfaction data in Table 3 shows that the repair cream provided in this application scored well in three dimensions: recurrence rate, improvement of erythema in the lesion area, and fading of pigmentation. This indicates that the repair cream provided in this application can reduce the recurrence rate of acne while treating acne, and effectively improve the residual erythema and pigmentation problems after acne is cured.

[0154] Analysis of Application Examples 7 and 10-11 shows that Application Example 7 further added Hedyotis diffusa extract and Ophiopogon japonicus extract to the ginseng composition, Application Example 10 replaced Hedyotis diffusa extract, and Application Example 11 replaced Ophiopogon japonicus extract. Application Example 7 has a good effect on inhibiting telangiectasia and reducing facial erythema and pigmentation. This shows that the further addition of Hedyotis diffusa extract and Ophiopogon japonicus extract to the ginseng composition has the effect of reducing facial erythema and pigmentation, and can better help acne sites recover to normal skin condition more quickly.

[0155] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A ginseng composition for treating acne, characterized in that, The ginseng composition comprises, by weight, 1-3 parts ginseng extract, 1-3 parts andrographis paniculata leaf extract, 0.05-0.1 parts canavalia gladiolus fruit extract, 0.05-0.1 parts papaya fruit extract and 0.05-0.1 parts peony root extract.

2. The ginseng composition for treating acne according to claim 1, characterized in that, The ginseng composition further includes licorice root extract, arborvitae leaf extract, loquat leaf extract and selaginella extract, comprising, by weight, 2-5 parts of licorice root extract, 0.005-0.01 parts of arborvitae leaf extract, 0.005-0.01 parts of loquat leaf extract and 0.005-0.01 parts of selaginella extract.

3. The ginseng composition for treating acne according to claim 1, characterized in that, The ginseng composition further includes extracts of Hedyotis diffusa and Ophiopogon japonicus, comprising 0.05 to 0.1 parts of Hedyotis diffusa extract and 0.005 to 0.01 parts of Ophiopogon japonicus extract by mass fraction of the ginseng composition.

4. A repair cream, characterized in that, The ginseng composition as described in any one of claims 1 to 3 is characterized in that it comprises 0.4% to 2% ginseng composition by weight percentage of the repair cream.

5. The repair cream according to claim 4, characterized in that, The repair cream contains, by weight percentage, 0.4%–2% ginseng composition, 9%–17% emollient, 1%–2.3% cooling agent, 1%–5% skin conditioning agent, 8%–18% emulsifier, 0.1%–0.4% thickener, 0.5%–1% penetrant, 0.1%–0.5% antioxidant, 0.01%–0.05% fragrance, 0.001%–0.002% colorant, with the balance being solvent.

6. The repair cream according to claim 5, characterized in that, The emollients include ethylhexyl palmitate, mineral oil, white beeswax, and polydimethylsiloxane, comprising 5% to 8% ethylhexyl palmitate, 3% to 5% mineral oil, 1% to 3% white beeswax, and 0.5% to 1% polydimethylsiloxane by weight percentage of the repair cream.

7. The repair cream according to claim 5, characterized in that, The skin conditioning agent includes salicylic acid, niacinamide, allantoin, dipotassium glycyrrhizate, β-glucan, and phytosterols, comprising, by weight percentage, 0.1%~0.5% salicylic acid, 0.1%~0.3% niacinamide, 0.1%~0.3% allantoin, 0.01%~0.02% dipotassium glycyrrhizate, 0.01%~0.02% β-glucan, and 1%~3% phytosterols.

8. The repair cream according to claim 5, characterized in that, The cooling agent includes menthol and borneol, comprising 1% to 2% menthol and 0.1% to 0.3% borneol by weight percentage of the repair ointment.

9. A repair cream according to claim 5, characterized in that, The penetrant is laurocapram.

10. A method for preparing a repair cream as described in any one of claims 4 to 9, characterized in that, Includes the following steps: Step 1: Put the solvent into the emulsification pot, heat it to 80-85℃, add the flavoring agent and stir well; Step 2: Mix the emollient, emulsifier, thickener and antioxidant and pour into the oil pan. While stirring, heat to 80-85℃ and then transfer to the emulsification pan to mix with the material obtained in Step 1. Step 3: Homogenize the material obtained in Step 2, vacuum it, and then cool it to 42~48℃. Add the remaining raw materials, stir thoroughly, and you will get the repair cream.