A method and device for adjusting stimulation parameters of an antiemetic instrument based on electrode load feedback

Abstract

The application discloses a kind of based on electrode load feedback's antiemetic instrument stimulation parameter adjustment method and device, it is related to percutaneous electric nerve stimulation technical field.The based on electrode load feedback's antiemetic instrument stimulation parameter adjustment method, current stimulation parameter and electrode load response sequence are acquired, reference load segment, candidate adjustment position and candidate stimulation parameter are determined, front-end reference load segment, candidate parameter effect segment, reference load response in section and rear-end reference load segment are formed, electrode load reference sequence is reconstructed, candidate parameter response sequence is formed and double-end verification is carried out, parameter effect response is obtained, and target stimulation parameter is determined according to this and generates stimulation output control signal.The application reconstructs electrode load reference sequence during candidate parameter effect period, and carries out double-end verification in combination with parameter switching entry and exit, separates the response change corresponding to load change and stimulation parameter adjustment, so that the determination of target stimulation parameter is more suitable for current electrode load state.

Description

Technical Field

[0001] This invention relates to the field of transcutaneous electrical nerve stimulation technology, specifically to a method and device for adjusting stimulation parameters of an antiemetic based on electrode load feedback. Background Technology

[0002] The anti-nausea device outputs electrical pulses through electrodes that fit against the skin of the wrist, providing transcutaneous electrical stimulation to the median nerve in the wrist to relieve nausea and vomiting. During use, the output intensity can be adjusted by changing different stimulation levels to suit the stimulation needs of different users.

[0003] Electrical stimulation acts on the human body after forming a conduction path between the electrodes and the skin. When the conductivity of the human skin and the adhesion of the electrodes change, the load response of the electrodes will change accordingly. At the same time, the adjustment of stimulation parameters will also change the corresponding load response. Existing products use multiple output voltages and preset pulse parameters for stimulation, with different levels corresponding to different output conditions.

[0004] The limitations of the existing technology include at least the following problems: When adjusting stimulation parameters using electrode load feedback, both the adjustment of stimulation parameters and the change in electrode load will be reflected in the subsequent load response. This means that the load response before and after parameter adjustment is affected by both the change in output conditions and the actual load change. When adjusting stimulation parameters based on the changes in the load response before and after, it is easy to make a deviation in the judgment of the actual electrode load change, which in turn causes the adjustment direction or adjustment range of the subsequent stimulation parameters to not correspond to the current electrode load state. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a method and apparatus for adjusting stimulation parameters of an antiemetic device based on electrode load feedback. This method solves the problem that the load response changes caused by stimulation parameter adjustments are mixed with the actual electrode load changes, leading to deviations in the direction and amplitude of subsequent stimulation parameter adjustments.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback, comprising the following steps: acquiring the current stimulation parameters and the current electrode load response sequence arranged according to the stimulation pulse time; determining the reference load segment before continuous offset, the candidate adjustment position, and the candidate stimulation parameters based on the current electrode load response sequence; forming a front-end reference load segment based on the current stimulation parameters before the candidate adjustment position; switching to the candidate stimulation parameters to obtain the candidate load response and forming a candidate parameter action segment; temporarily restoring the current stimulation parameters to obtain the intra-segment reference load response during this period; restoring the current stimulation parameters after the candidate parameter action segment ends to form a rear-end reference load segment; reconstructing the electrode load reference sequence corresponding to the candidate parameter action segment based on the front-end reference load segment, the intra-segment reference load response, and the rear-end reference load segment; forming a candidate parameter response sequence based on the candidate load response and the electrode load reference sequence; performing double-end verification of the candidate parameter response sequence based on the parameter switching responses before and after the parameter switching at the inlet and outlet of the candidate parameter action segment to form a parameter action response; determining the target stimulation parameter based on the parameter action response, the electrode load reference sequence, and the reference load segment; and generating the stimulation output control signal corresponding to the target stimulation parameter.

[0007] Further, the steps for obtaining the current electrode load response sequence are as follows: output a stimulation pulse according to the current stimulation parameters, and collect the detection signal at the electrode output end based on the output time of the stimulation pulse; divide the detection signal at the electrode output end according to the stimulation pulse action period and recovery period to form a pulse detection segment; analyze the changes in the detection signal of the pulse detection segment during the stimulation pulse action period and recovery period to form a single-pulse electrode load response; arrange the single-pulse electrode load responses according to the stimulation pulse time to form the current electrode load response sequence.

[0008] Further, the steps for determining the baseline load segment, candidate adjustment positions, and candidate stimulation parameters are as follows: Analyze the current electrode load response sequence sequentially to determine the starting position where the electrode load response begins to continuously deviate from the previous continuous response range; select the continuous electrode load responses before the starting position to form the baseline load segment; connect the electrode load responses with the same offset direction and adjacent time from the starting position to form candidate load change segments; when the candidate load change segment reaches a preset duration range, determine the corresponding position as the candidate adjustment position; based on the offset direction of the candidate load change segment and the preset correspondence between the load offset direction and the stimulation parameter adjustment direction, select stimulation parameters adjacent to the current stimulation parameter from the preset stimulation parameter table to form candidate stimulation parameters.

[0009] Further, the steps for forming the front-end reference load segment are as follows: taking the candidate adjustment position as the end, extract the continuous electrode load response obtained according to the current stimulation parameters from the current electrode load response sequence; determine the continuous response interval that is continuously connected to the candidate adjustment position and whose adjacent electrode load response change direction remains unchanged from the candidate adjustment position; form the front-end reference load segment from the electrode load responses within the continuous response interval.

[0010] Further, the steps for forming candidate parameter action segments and intra-segment reference load responses are as follows: switch to candidate stimulus parameters at the candidate adjustment position, continuously acquire candidate load responses to form candidate parameter action segments; after continuously acquiring a preset number of candidate load responses, temporarily restore the current stimulus parameters to acquire the first intra-segment reference load response, and then restore the candidate stimulus parameters; compare the change amplitude of two adjacent sets of candidate load responses, shorten the acquisition interval of intra-segment reference load responses when the change amplitude shows an expanding trend, and extend the acquisition interval when it shows a converging trend; repeat the acquisition of intra-segment reference load responses according to the adjusted acquisition interval, and restore the candidate stimulus parameters after each acquisition until the candidate parameter action segment ends.

[0011] Furthermore, the steps for forming the back-end reference load segment are as follows: after the candidate parameter action segment ends, the current stimulation parameter is restored, and the electrode load response is continuously obtained; starting from the first electrode load response, the direction of change of adjacent electrode load responses is analyzed; the electrode load responses whose direction of change is not reversed and whose time is adjacent are connected to form the back-end reference load segment.

[0012] Further, the steps for reconstructing the electrode load reference sequence are as follows: extract the electrode load response at the end of the front reference load segment, the reference load response within each segment, and the electrode load response at the beginning of the rear reference load segment, and arrange them according to the stimulation pulse time to form a reference load node sequence; determine the node interval where each candidate load response is located based on adjacent reference load nodes; determine the corresponding reference load response based on the time position of the candidate load response within the node interval and the response changes at both ends of the node interval; arrange the reference load responses according to the stimulation pulse time to form the electrode load reference sequence.

[0013] Further, the steps for forming the parameter action response are as follows: Extract the electrode load response and the first candidate load response before switching at the entrance of the candidate parameter action segment, and correct the load change at the corresponding time according to the electrode load reference sequence to form the entrance parameter response; extract the last candidate load response and the first electrode load response after restoring the current stimulation parameter at the exit of the candidate parameter action segment, and form the exit parameter response in the same way; analyze each candidate load response with the corresponding reference load response to form a candidate parameter response sequence; convert the exit parameter response to the same parameter switching direction as the entrance parameter response, and perform response deviation analysis on the entrance side and the exit side of the candidate parameter response sequence according to the entrance parameter response and the converted exit parameter response to form a two-end verification result; when the two-end verification result meets the preset allowable conditions, a parameter action response is formed; when the preset allowable conditions are not met, the front-end reference load segment, the candidate parameter action segment, and the back-end reference load segment are re-formed, and an intra-segment reference load response is added at the corresponding end. After updating the electrode load reference sequence, the two-end verification is repeated.

[0014] Further, the steps for determining the target stimulus parameter are as follows: obtain the reference load response at the end of the electrode load reference sequence, and form the current load offset based on its response change relative to the reference load segment; correct the current load offset based on the parameter action response to form the remaining load offset; when the remaining load offset is within a preset allowable range, determine the candidate stimulus parameter as the target stimulus parameter; when the remaining load offset exceeds the preset allowable range, select the stimulus parameter adjacent to the candidate stimulus parameter as the new candidate stimulus parameter according to the direction of the remaining load offset, and re-execute the candidate parameter action segment formation, reference load reconstruction, and parameter action response formation process until the target stimulus parameter is determined.

[0015] An electrode load feedback-based stimulation parameter adjustment device for an antiemetic includes: a load response acquisition module for acquiring current stimulation parameters and a current electrode load response sequence; an adjustment parameter determination module for determining a reference load segment, candidate adjustment positions, and candidate stimulation parameters based on the current electrode load response sequence; a reference stimulation control module for generating a front-end reference load segment, a candidate parameter action segment, an intra-segment reference load response, and a rear-end reference load segment; a load reference reconstruction module for reconstructing the electrode load reference sequence; a parameter response processing module for generating a candidate parameter response sequence and, after double-end verification, generating a parameter action response; and a stimulation parameter control module for determining a target stimulation parameter based on the parameter action response, the electrode load reference sequence, and the reference load segment, and generating a stimulation output control signal corresponding to the target stimulation parameter.

[0016] The present invention has the following beneficial effects:

[0017] (1) The method for adjusting the stimulation parameters of the antiemetic device based on electrode load feedback obtains a front-end reference load segment according to the current stimulation parameter before the candidate stimulation parameter is applied, temporarily restores the reference load response within the segment obtained by the current stimulation parameter during the application of the candidate stimulation parameter, and restores the back-end reference load segment obtained by the current stimulation parameter after the application of the candidate parameter. This ensures that the reference load responses obtained before, during, and after the application of the candidate parameter all correspond to the current stimulation parameter. Based on this, the electrode load reference sequence corresponding to the application of the candidate parameter is reconstructed, so that the load response changes caused by changes in skin conductivity and wearing fit can be processed separately from the response changes caused by switching stimulation parameters. This reduces the deviation in adjustment direction caused by misjudging the response changes generated by the adjustment of stimulation parameters as changes in electrode load.

[0018] (2) The method for adjusting the stimulation parameters of the antiemetic device based on electrode load feedback obtains the reference load response within the segment by interspersing the current stimulation parameter within the segment of the candidate parameter action. The interval for obtaining the reference load response within the segment is adjusted according to the change amplitude of the adjacent candidate load response. When the change amplitude of the candidate load response increases, the interval is shortened; when the change amplitude converges, the interval is extended. This allows for denser references of the same parameter during periods when the candidate load response changes rapidly, and reduces the insertion intervention on the output process of the candidate stimulation parameter during periods when the candidate load response changes slowly. The reference load nodes covering the action process of the candidate parameter are formed by the front-end reference load segment and the back-end reference load segment, so that the reconstructed electrode load reference sequence fits the actual load change process.

[0019] (3) The method for adjusting the stimulation parameters of the antiemetic device based on electrode load feedback extracts the response when the current stimulation parameter is switched to the candidate stimulation parameter at the entrance of the candidate parameter action segment and the response when the candidate stimulation parameter is restored to the current stimulation parameter at the exit. The exit parameter response is converted to the same parameter switching direction as the entrance parameter response. The response deviation analysis is performed with the adjacent inner responses of the entrance and exit sides of the candidate parameter response sequence, so that the candidate parameter action response is simultaneously verified by the entrance switching relationship and the exit restoration relationship. When the double-end verification result does not meet the preset allowable conditions, the reference load segment is re-formed and the intra-segment reference load response at the corresponding position is added. The electrode load reference sequence is updated accordingly to reduce the judgment deviation caused by determining the action state of the candidate stimulation parameter based only on the parameter switching result on one side.

[0020] (4) The stimulation parameter adjustment device of the antiemetic based on electrode load feedback obtains the current stimulation parameters and the current electrode load response sequence through the load response acquisition module, determines the reference load segment, candidate adjustment position and candidate stimulation parameters by the adjustment parameter determination module, and then organizes the switching process between the current stimulation parameters and candidate stimulation parameters by the reference stimulation control module. The load reference reconstruction module forms the electrode load reference sequence, the parameter response processing module completes the double-end verification of the candidate parameter response sequence, and the stimulation parameter control module determines the target stimulation parameter by combining the parameter action response, the electrode load reference sequence and the reference load segment, so that the electrode detection, stimulation parameter trial adjustment, load change separation and stimulation output control form a corresponding closed-loop control process.

[0021] Of course, any product implementing this invention does not necessarily need to achieve all of the advantages described above at the same time. Attached Figure Description

[0022] Figure 1 This is a flowchart of a method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback, according to the present invention.

[0023] Figure 2 This is a schematic diagram of the antiemetic device structure in the antiemetic device stimulation parameter adjustment method based on electrode load feedback of the present invention.

[0024] Figure 3 This is a schematic diagram of the stimulation output and detection circuit in the stimulation parameter adjustment method of an antiemetic device based on electrode load feedback according to the present invention.

[0025] Figure 4 This is a block diagram of a stimulation parameter adjustment device for an antiemetic based on electrode load feedback according to the present invention.

[0026] In the diagram: 1. Control unit; 2. Status indicator unit; 3. Wristband; 4. Electrode; 5. Controller; 6. Stimulation output and detection circuit; 7. Output and detection terminal. Detailed Implementation

[0027] Please see Figure 1This invention provides a technical solution: a method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback, comprising the following steps: acquiring the current stimulation parameters and the current electrode load response sequence arranged according to the stimulation pulse time; determining the reference load segment before continuous offset, candidate adjustment position, and candidate stimulation parameters based on the current electrode load response sequence; forming a front-end reference load segment based on the current stimulation parameters before the candidate adjustment position; switching to the candidate stimulation parameters to obtain the candidate load response and forming a candidate parameter action segment; temporarily restoring the current stimulation parameters to obtain the intra-segment reference load response during this period; restoring the current stimulation parameters after the candidate parameter action segment ends to form a rear-end reference load segment; reconstructing the electrode load reference sequence corresponding to the candidate parameter action segment based on the front-end reference load segment, the intra-segment reference load response, and the rear-end reference load segment; forming a candidate parameter response sequence based on the candidate load response and the electrode load reference sequence; performing double-end verification of the candidate parameter response sequence based on the parameter switching responses before and after the parameter switching at the entrance and exit of the candidate parameter action segment to form a parameter action response; determining the target stimulation parameter based on the parameter action response, the electrode load reference sequence, and the reference load segment, and generating a stimulation output control signal corresponding to the target stimulation parameter.

[0028] Among them, the current stimulus parameter represents the stimulus level and corresponding output control parameter being executed when the current adjustment is triggered. Before the target stimulus parameter is determined, the front-end reference load segment, the intra-segment reference load response and the back-end reference load segment are obtained based on the current stimulus parameter.

[0029] Electrode load response represents the load characterization quantity formed by the change in the detection state of the detection signal at the electrode output end during the stimulation pulse application period and the recovery period, and is not limited to the directly measured impedance value;

[0030] The positive direction of the response indicates the direction in which the single-pulse electrode load response value increases, and the negative direction of the response indicates the direction in which the single-pulse electrode load response value decreases. When it comes to directional changes, offset directions, parameter responses, and residual load offsets, the positive and negative values ​​are determined according to the above directions.

[0031] The calibration equivalent load refers to a standard load connected to the electrode output terminal during the equipment calibration phase, with a predetermined impedance value.

[0032] The preset stimulation parameter table stores the allowed stimulation levels and their corresponding output control parameters;

[0033] The preset length of the front observation window indicates the number of consecutive stimulation pulses used to calculate the average value and average absolute deviation of the front response;

[0034] During the equipment calibration phase, single-pulse electrode load responses are continuously acquired and normalized offset is calculated while the calibration equivalent load remains unchanged. The maximum value of the absolute value of the obtained normalized offset is determined as the preset offset threshold. Subsequently, the calibration equivalent load is kept unchanged and single-pulse electrode load responses are acquired. The number of consecutive stimulation pulses corresponding to when the absolute value of the normalized offset exceeds the preset offset threshold and the sign remains unchanged is counted. The number corresponding to the maximum number of consecutive stimulation pulses plus one stimulation pulse is determined as the preset duration range.

[0035] The preset number before the reference load response is obtained in the first segment indicates the number of stimulation pulses that continuously obtain the candidate load response after the candidate stimulus parameters are entered, which can at least form the change amplitude of two consecutive sets of candidate load responses.

[0036] The preset length of the candidate parameter action segment represents the number of stimulus pulses covered by a single candidate test, and is set so that when the reference load response within the segment is obtained at the preset shortest acquisition interval, the number of candidate load responses obtained according to the candidate stimulus parameters, in addition to the reference stimulus pulse within the segment, is still no less than four.

[0037] The preset shortest acquisition interval and the preset longest acquisition interval represent the lower limit and upper limit of the number of candidate stimulation pulses corresponding to the entry of the candidate parameter action segment to the first intra-segment reference load response, the interval between adjacent intra-segment reference load responses, and the interval between the last intra-segment reference load response to the exit of the candidate parameter action segment, respectively. The above preset values ​​are determined and written into the controller 5 during the equipment calibration stage.

[0038] like Figure 2 As shown, in one embodiment, the anti-nausea device includes a control unit 1, a status indicator unit 2, a wristband 3, and electrodes 4. The two electrodes 4 are disposed on the side of the anti-nausea device facing the skin of the wrist. The wristband 3 is used to keep the electrodes 4 in contact with the wrist. The control unit 1 is used to receive stimulation level adjustment commands. The status indicator unit 2 is used to display the corresponding working status. In this embodiment, when the electrode load feedback adjustment is performed, the electrodes 4 form the stimulation output path.

[0039] like Figure 3 As shown, in one embodiment, the controller 5 is connected to the corresponding stimulation control terminals of EMSA, EMSB and EMSPWM, and controls the stimulation output and detection circuit 6 to execute stimulation pulse output through the corresponding control signals. The output and detection terminal 7 includes a CH1+ output terminal, a CH1- output terminal and an EMS_H_det detection signal terminal. The CH1+ output terminal and the CH1- output terminal are connected to the electrode 4, and the EMS_H_det detection signal terminal is connected to the detection input terminal of the controller 5. The controller 5 reads the high and low level states corresponding to EMS_H_det according to the stimulation pulse control timing and forms the electrode output terminal detection signal.

[0040] The stimulation pulse is output according to the current stimulation parameters, and the detection signal at the electrode output terminal is acquired based on the output time of the stimulation pulse. Specifically:

[0041] The controller 5 records the start and end times of each stimulation pulse, and reads the high and low level status of the detection signal at the electrode output terminal according to a fixed reading cycle within the preset sampling window before the start of each stimulation pulse, the stimulation pulse action period, and the recovery period. The preset sampling window is located before the start of the current stimulation pulse and does not cross into the action period of the previous stimulation pulse. Its length is set according to the reading cycle of the controller 5 and the interval between adjacent stimulation pulses.

[0042] The detection signal at the electrode output is divided into pulse detection segments according to the stimulation pulse duration and recovery duration, which are as follows:

[0043] The period from the start to the end of the current stimulation pulse is defined as the stimulation pulse action period, and the period from the end of the current stimulation pulse to the start of the next stimulation pulse is defined as the recovery period. The preset sampling window, stimulation pulse action period, and recovery period corresponding to the same stimulation pulse are grouped into the same pulse detection segment.

[0044] The changes in the detection signal of the pulse detection segment during the stimulation pulse and the recovery period are analyzed to form a single-pulse electrode load response, which is as follows:

[0045] The detection states that appear most frequently within the preset sampling window are defined as pre-pulse detection states. The proportion of reads that differ from the pre-pulse detection states during the stimulation pulse application period and recovery period is calculated to the total number of reads during the corresponding period, and a single-pulse electrode load response is generated.

[0046] ;

[0047] In the formula, Indicates the first The single-pulse electrode load response corresponding to each stimulation pulse. Indicates the first The proportion of reads that differed from the pre-pulse detection state during the duration of each stimulus pulse out of the total number of reads during that duration. This indicates the proportion of reads that differed from the pre-pulse detection state within the corresponding recovery period, out of the total number of reads during the recovery period. This represents the combination coefficient for the period of action and its value is between zero and one.

[0048] Candidates are set sequentially during the equipment calibration phase. For calibrated equivalent loads with different impedance values, repeated testing is performed. Candidate values ​​are retained where the single-pulse electrode load response always corresponds to the same direction of change when the calibrated equivalent load impedance changes in a predetermined direction. The results obtained from repeated testing for each calibrated equivalent load are calculated. The average absolute deviation is calculated, and the average absolute deviation corresponding to each calibrated equivalent load is taken as the candidate value with the smallest average deviation. It remains unchanged during the same round of adjustments.

[0049] The single-pulse electrode load responses are arranged according to the timing of the stimulation pulse to form the current electrode load response sequence, which is as follows:

[0050] Using the start time of the stimulation pulse as the sorting index, the responses of each single-pulse electrode load are arranged in the output order, and the corresponding stimulation parameters and stimulation pulse times are saved.

[0051] By sequentially analyzing the current electrode load response sequence, the starting point at which the electrode load response begins to deviate continuously from the range of the previous continuous response is determined. Specifically:

[0052] Extract the continuous response that reaches the preset length of the previous observation window before the single-pulse electrode load response to be judged, calculate the average response value and the average absolute deviation, and calculate the normalized offset of the single-pulse electrode load response to be judged:

[0053] ;

[0054] In the formula, Indicates the first The normalized offset of the single-pulse electrode load response to be judged. This represents the average value of the single-pulse electrode load response within the current observation window. This indicates the relative response of the single-pulse electrode load within the aforementioned observation window. The mean absolute deviation This represents a pre-set, extremely small positive number and is used only to avoid a denominator of zero.

[0055] The response to be judged Update the front-end observation window when the absolute value does not exceed the preset offset threshold, and update the window when the first absolute value exceeds the preset offset threshold. The previous observation window was fixed at that position, and the fixed window was used. and Process the subsequent response, then When the same sign is maintained and the number of consecutive signs reaches the preset duration range, the first position that crosses the preset offset threshold is determined as the starting position. If any of the following occurs before reaching the preset duration range: sign change or absolute value returns to within the preset offset threshold, the fixing is lifted and the front observation window continues to be updated.

[0056] A reference load segment is formed by selecting continuous electrode load responses prior to the starting position. Candidate load change segments are formed by connecting electrode load responses with the same offset direction and adjacent time from the starting position. Specifically:

[0057] The continuous electrode load response within the fixed observation window at the initial position is defined as the reference load segment. Starting from the initial position, ... The symbolic connection of the stimulation pulses is continuous in timing and has the same offset direction in the electrode load response. When the sign is zero, the corresponding response is retained and not used as a basis for changing the direction; when the sign changes, the connection is stopped.

[0058] When a candidate load change segment reaches a preset duration range, the corresponding position is determined as a candidate adjustment position, specifically as follows:

[0059] The number of consecutive stimulation pulses with a constant offset direction is accumulated from the starting position of the candidate load change segment. When the accumulated result reaches the preset duration range, the parameter switching position after the end of the corresponding end stimulation pulse is determined as the candidate adjustment position.

[0060] Based on the offset direction of the candidate load change segments and the preset correspondence between the load offset direction and the stimulus parameter adjustment direction, stimulus parameters adjacent to the current stimulus parameter are selected from the preset stimulus parameter table to form candidate stimulus parameters, specifically:

[0061] During the equipment calibration phase, the equivalent load is changed sequentially according to the impedance value. Adjacent stimulation levels are executed under each equivalent load. The electrode load response offset direction caused by the change of the equivalent load is recorded, as well as the parameter response direction corresponding to increasing and decreasing the stimulation level. The stimulation level adjustment direction that is opposite to the corresponding electrode load response offset direction is determined as the compensation direction corresponding to the load offset direction. During the operation phase, the offset direction of the candidate load change segment is read and the corresponding compensation direction is determined. The stimulation parameter that is adjacent to the current stimulation parameter and located in the compensation direction is selected from the preset stimulation parameter table as the candidate stimulation parameter.

[0062] In one implementation, when the compensation direction corresponding to the candidate load change segment is to increase the stimulation level, the higher stimulation level adjacent to the current stimulation level is selected; when the corresponding compensation direction is to decrease the stimulation level, the lower stimulation level adjacent to the current stimulation level is selected.

[0063] In this implementation scheme, the baseline load segment corresponds to the response range before the occurrence of sustained offset, and the front-end reference load segment corresponds to the current stimulus parameter response at the adjacent candidate adjustment position before the candidate stimulus parameter is cut in.

[0064] Using the candidate adjustment position as the end, the continuous electrode load response obtained according to the current stimulation parameters is extracted from the current electrode load response sequence, specifically as follows:

[0065] Starting from the previous stimulation pulse corresponding to the candidate adjustment position, read backward along time to the beginning of the reference load segment, and retain only the electrode load response where the stimulation parameter is equal to the current stimulation parameter and the stimulation pulse time is continuous.

[0066] From the candidate adjustment position, a continuous response interval is determined that is continuously connected to the candidate adjustment position and whose direction of change of adjacent electrode load response remains unchanged. Specifically:

[0067] The directional changes in the load response of adjacent electrodes are checked sequentially in reverse time. Adjacent responses with zero change values ​​are skipped. The direction of change is determined by the first non-zero directional change. Subsequent directional changes continue to expand when they remain in the same direction, and expansion stops when they appear in opposite directions. When all directional changes within the intercepted response range are zero, the intercepted response range is determined as the continuous response interval.

[0068] The electrode load response within the continuous response interval is used to form a front-end reference load segment, specifically as follows:

[0069] The electrode load responses within the continuous response interval are arranged according to the timing of the stimulation pulse, and the electrode load response closest to the candidate adjustment position is determined as the end response of the front-end reference load segment.

[0070] Switching from the candidate modulation position to the candidate stimulus parameter, and continuously acquiring the candidate load response, forms a candidate parameter action segment, which is specifically as follows:

[0071] The controller 5 calls the output control parameters corresponding to the candidate stimulation parameters, obtains the candidate load response corresponding to each candidate stimulation pulse according to the same detection and calculation method as the single pulse electrode load response, and arranges them according to the stimulation pulse time to form the candidate parameter action segment.

[0072] After obtaining a preset number of candidate load responses, the current stimulus parameters are temporarily restored to obtain the first intra-segment reference load response, and then the candidate stimulus parameters are restored, specifically as follows:

[0073] After the candidate stimulus parameters are continuously output to a preset number, the next complete stimulus pulse is temporarily switched to the current stimulus parameters. The intra-segment reference load response is obtained according to the same detection and calculation method. Then the candidate stimulus parameters are restored to continue obtaining the candidate load response.

[0074] Compare the variation amplitudes of adjacent candidate load responses. When the variation amplitude shows an increasing trend, shorten the interval for obtaining the reference load response within the segment; when it shows a converging trend, lengthen the interval. Specifically:

[0075] The absolute change between adjacent candidate load responses is calculated sequentially. When the current change is higher than the previous change, the next acquisition interval is reduced by one candidate stimulus pulse. When the current change is lower than the previous change, one candidate stimulus pulse is added. When the two are the same, the current acquisition interval is maintained. The adjusted acquisition interval is limited by the preset minimum acquisition interval and the preset maximum acquisition interval.

[0076] The reference load response within the segment is repeatedly acquired according to the adjusted acquisition interval. After each acquisition, the candidate stimulus parameters are restored until the segment in which the candidate parameters act ends. Specifically:

[0077] After the most recent intra-segment reference load response is obtained, the number of stimulation pulses corresponding to the candidate stimulation parameters is accumulated. When the current acquisition interval is reached, the next complete stimulation pulse is switched to the current stimulation parameter and the intra-segment reference load response is obtained. Then the candidate stimulation parameters are restored and the accumulation is restarted. The preset minimum acquisition interval retains at least one candidate stimulation pulse, and the preset maximum acquisition interval ensures that at least one intra-segment reference load response is obtained within the action segment of the candidate parameter, and the number of candidate load responses in the entire action segment of the candidate parameter is not less than four.

[0078] In this implementation scheme, the front-end reference load segment, the intra-segment reference load response, and the back-end reference load segment are all obtained according to the current stimulus parameters when the current round of adjustment is triggered.

[0079] After the candidate parameter action period ends, the current stimulation parameter is restored, and the electrode load response is continuously obtained, specifically as follows:

[0080] Once the candidate parameter action segment reaches the preset length, the output of the candidate stimulation parameter stops, the current stimulation parameter is restored, the stimulation pulse is continuously executed, and the corresponding electrode load response is obtained. The acquisition stops when the number of responses obtained reaches the number of responses contained in the front-end reference load segment and is not less than two.

[0081] The analysis begins with the load response of the first electrode, examining the changing direction of the load responses of adjacent electrodes. Specifically:

[0082] The directional changes in the adjacent electrode load responses after the current stimulation parameters are restored are checked in chronological order. Adjacent responses with zero change values ​​are skipped. The first non-zero directional change is used to determine the starting change direction. Subsequently, when the change value is zero, the corresponding response is retained and not used as the basis for reversing the direction. When the number of consecutively obtained responses reaches the number of responses contained in the front-end reference load segment and is not less than two, if the directional changes of adjacent responses are all zero, the obtained responses are directly used as the back-end reference load segment.

[0083] The electrode load responses with non-reversed direction of change and adjacent time intervals form a back-end reference load segment, which is specifically as follows:

[0084] When there is a non-zero initial change direction, start connecting the electrode load responses with the same initial change direction and continuous stimulation pulse times from the first electrode load response after the current stimulation parameters are restored. Stop connecting when the opposite change direction appears, and arrange them according to the stimulation pulse times to form the back-end reference load segment.

[0085] The electrode load responses at the end of the front reference load segment, the reference load responses within each segment, and the electrode load responses at the beginning of the rear reference load segment are extracted and arranged according to the stimulation pulse time to form a reference load node sequence, specifically as follows:

[0086] The end response of the front-end reference load segment is used as the ingress reference load node, the reference load response within each segment is used as the reference load node during the application of candidate parameters, and the start response of the back-end reference load segment is used as the exit reference load node. The stimulation pulse time corresponding to each node is saved.

[0087] The node intervals where each candidate load response is located are determined based on adjacent reference load nodes, specifically as follows:

[0088] Adjacent reference load nodes are selected sequentially according to the stimulation pulse time. The time range between two adjacent nodes is defined as the node interval, and the candidate load responses whose stimulation pulse time is within the corresponding range are assigned to the corresponding node interval.

[0089] Based on the time position of the candidate load response within the node interval and the response changes at both ends of the node interval, the corresponding reference load response is determined, specifically as follows:

[0090] For each node interval, interpolation is performed according to the stimulus pulse times corresponding to the reference load nodes at both ends and the candidate load responses, using a time-proportional method:

[0091] ;

[0092] In the formula, Indicates the first The reference load response at the corresponding time point for each candidate load response Indicates the time of the corresponding stimulus pulse. and These represent the stimulation pulse times at the start and end nodes of the node interval, respectively. and These represent the electrode load response of the corresponding nodes, and .

[0093] The reference load responses are arranged according to the timing of the stimulation pulses to form an electrode load reference sequence, which is as follows:

[0094] The reference load responses corresponding to each candidate load response are arranged in the order of candidate stimulus pulse output, and the end response of the front reference load segment and the beginning response of the back reference load segment are retained as the reference responses before the inlet and after the outlet, respectively.

[0095] Extract the electrode load response and the first candidate load response before switching at the entry point of the candidate parameter action segment. Correct the load change at the corresponding time according to the electrode load reference sequence to form the entry parameter response, which is as follows:

[0096] Obtain the electrode load response and the first candidate load response corresponding to the last current stimulation parameter before the candidate adjustment position, and obtain the reference response corresponding to the two response times. Subtract the directional change between the two reference responses from the directional change of the detection response before and after parameter switching, and determine the result as the inlet parameter response.

[0097] Extract the last candidate load response at the exit of the candidate parameter action fragment and the first electrode load response after restoring the current stimulation parameters. Form the exit parameter response in the same way, specifically as follows:

[0098] Obtain the last candidate load response and the first electrode load response after restoring the current stimulation parameters, and obtain the reference responses corresponding to the two response times. Subtract the directional change between the two reference responses from the directional change of the detection response before and after parameter restoration, and determine the result as the exit parameter response.

[0099] The candidate load responses are analyzed in conjunction with the corresponding reference load responses to form a candidate parameter response sequence, which is as follows:

[0100] Calculate the directed difference between each candidate load response and the reference load response at the same stimulus pulse time, following the positive direction of the response. Use these directed differences as candidate parameter responses and arrange them according to the candidate stimulus pulse times to form a candidate parameter response sequence. The candidate parameter response sequence is then denoted as follows: ,in This indicates the number of candidate load responses within the segment in which the candidate parameter is applied, and m is not less than four.

[0101] The exit parameter response is converted to the same parameter switching direction as the inlet parameter response. Based on the inlet parameter response and the converted exit parameter response, response deviation analysis is performed on the inlet and outlet sides of the candidate parameter response sequence to form a two-end verification result, which is as follows:

[0102] After resigning the exit parameter response, an exit parameter response with the same parameter switching direction as the inlet parameter response is generated. A second candidate parameter response is then extracted from the inlet side of the candidate parameter response sequence. Extract candidate parameter responses from the export side before the last candidate parameter response. Response based on input parameters and The response deviation, the output parameter response after changing the sign and The response bias and the difference between the two response biases are used to calculate the two-ended check value:

[0103] ;

[0104] In the formula, Indicates the two-end verification value. Indicates the response to the input parameters. This indicates the output parameter response after the sign is changed. This represents the average of the absolute values ​​of the responses of each candidate parameter in the candidate parameter response sequence.

[0105] The first part of the formula takes the larger of the inlet and outlet response deviations, and the second part represents the difference between the directional response deviations at both ends.

[0106] The ingress parameter response is formed by the actual response change at the candidate stimulus parameter entry boundary, corresponding to the ingress boundary of the candidate parameter action segment. The exit parameter response after sign change is formed by the actual response change at the exit boundary of the candidate stimulus parameter, corresponding to the exit boundary of the candidate parameter action segment. This allows the two-end verification to make judgments based on the deviation relationship between the parameter switching boundary response and the adjacent responses inside the candidate parameter action segment.

[0107] The preset dual-end verification threshold is determined during the equipment calibration phase by switching the stimulation parameters back and forth when the calibration equivalent load remains unchanged. For calibration equivalent loads with different impedance values ​​that remain unchanged, the back and forth switching is performed according to the stimulation parameter switching relationship that can be formed during the operation phase in the preset stimulation parameter table. The dual-end verification value is calculated according to the same dual-end verification process as the operation phase, and the maximum value of the obtained dual-end verification value is determined as the preset dual-end verification threshold and then written into the controller 5.

[0108] When the two-end verification result meets the preset allowable conditions, a parameter action response is generated. If the preset allowable conditions are not met, the front-end reference load segment, candidate parameter action segment, and back-end reference load segment are regenerated, and an intra-segment reference load response is added at the corresponding end. After updating the electrode load reference sequence, the two-end verification is repeated. Specifically:

[0109] If the response does not exceed the preset double-end verification threshold, the double-end verification is deemed successful and the candidate parameter response sequence is determined as the parameter action response.

[0110] When the preset dual-end verification threshold is exceeded, the inlet response deviation and the outlet response deviation are compared. If the inlet response deviation is large, the acquisition interval between the inlet and the reference load response in the first segment is shortened. If the outlet response deviation is large, the acquisition interval between the reference load response in the last segment and the outlet is shortened. If the two are the same, the corresponding acquisition interval is shortened at the same time.

[0111] Each time the interval is reduced by one candidate stimulation pulse and is subject to the preset minimum acquisition interval, after the adjustment is completed, the current stimulation parameter is maintained to continuously acquire the electrode load response to form a new front-end reference load segment. Then, the same candidate stimulation parameter is switched back to form a new candidate parameter action segment, intra-segment reference load response and back-end reference load segment. After updating the electrode load reference sequence, the double-end verification is repeated.

[0112] If the required shortened acquisition interval has already reached the preset minimum acquisition interval, then the two-end verification should be completed again according to the preset minimum acquisition interval. If the threshold for dual-end verification is still exceeded, the current candidate stimulus parameter test will be terminated, the current stimulus parameter at the time of triggering this round of adjustment will be restored, and the current round of automatic adjustment will end.

[0113] Among them, the inlet response deviation represents and The absolute value of the response difference between the two ends, the output response deviation represents and The absolute value of the response difference between the two is used to determine the position where the acquisition interval needs to be shortened when the two-end verification fails.

[0114] Obtain the reference load response at the end of the electrode load reference sequence, and form the current load offset based on its response change relative to the reference load segment, specifically as follows:

[0115] Calculate the average value of the load response of each electrode within the reference load segment and determine it as the reference load center. Calculate the directed difference between the reference load response at the end of the electrode load reference sequence and the reference load center in the positive direction of the response, and determine the resulting directed difference as the current load offset.

[0116] The current load offset is corrected based on the parameter response to form the remaining load offset, which is as follows:

[0117] Obtain the candidate parameter response corresponding to the end of the parameter action response. When the candidate parameter response is opposite to the current load offset direction, the current load offset is canceled according to the corresponding amplitude of the candidate parameter response. When the candidate parameter response is in the same direction as the current load offset direction, the current load offset is continued according to the corresponding amplitude of the candidate parameter response. The processed directional offset is determined as the residual load offset. The residual load offset represents the response offset that is expected to be retained relative to the reference load center after the candidate stimulus parameter is applied, and does not represent the directly measured electrode impedance change.

[0118] When the remaining load offset is within a preset allowable range, the candidate stimulus parameter is determined as the target stimulus parameter, specifically as follows:

[0119] During the equipment calibration phase, the electrode load response is continuously obtained while each calibration equivalent load remains unchanged. The directed difference between each response and the corresponding average response value is calculated. The minimum to maximum directed difference among all calibration results is determined as the allowable range of load offset and written into controller 5. When the remaining load offset is within this range, the current candidate stimulation parameter is determined as the target stimulation parameter.

[0120] When the residual load offset exceeds the preset allowable range, a stimulus parameter adjacent to the candidate stimulus parameter is selected as a new candidate stimulus parameter according to the direction of the residual load offset. The process of candidate parameter action fragment formation, reference load reconstruction, and parameter action response formation is repeated until the target stimulus parameter is determined. Specifically:

[0121] Controller 5 establishes the test record of candidate stimulus parameters for this round. After each candidate stimulus parameter that has passed dual-end verification is completed, the corresponding stimulus parameter is recorded after calculating the remaining load offset.

[0122] When the remaining load offset is outside the allowable range of load offset, the stimulus parameter adjacent to the current candidate stimulus parameter and located in the corresponding compensation direction is selected from the preset stimulus parameter table as the new candidate stimulus parameter according to the correspondence between its offset direction and the load offset direction and the stimulus parameter adjustment direction.

[0123] When a new candidate stimulus parameter does not appear in the test record of the candidate stimulus parameter in this round, the current stimulus parameter at the time of triggering this round of adjustment is maintained to form a new front-end reference load segment. Then, the new candidate stimulus parameter is switched to and the candidate parameter action segment, intra-segment reference load response, back-end reference load segment, electrode load reference sequence and parameter action response are formed in the same steps.

[0124] When the remaining load offset is within the allowable range of load offset, the corresponding candidate stimulus parameter is determined as the target stimulus parameter.

[0125] When a new candidate stimulus parameter already exists in the test record of the candidate stimulus parameter in this round, the automatic parameter replacement in this round is stopped and the current stimulus parameter at the time when the adjustment was triggered is restored and the output continues.

[0126] When the current candidate stimulus parameter has reached the end of the compensation direction corresponding to the preset stimulus parameter table and the remaining load offset is still outside the allowable range of load offset, the automatic parameter replacement of this round will also be stopped and the current stimulus parameter at the time of triggering this round of adjustment will continue to be output. The above processing will not generate target stimulus parameters, and will be used as the exit processing when the candidate stimulus parameter search cannot continue.

[0127] In this implementation scheme, candidate stimulus parameters are determined as target stimulus parameters after being verified by both ends and the corresponding remaining load offset is within the allowable range of load offset. If the determination conditions for target stimulus parameters are not met, the candidate stimulus parameters in the test process will not be replaced with normal stimulus output parameters.

[0128] Please see Figure 4 This invention provides a technical solution: a stimulation parameter adjustment device for an antiemetic based on electrode load feedback, comprising: a load response acquisition module for acquiring current stimulation parameters and a current electrode load response sequence; an adjustment parameter determination module for determining a reference load segment, candidate adjustment positions, and candidate stimulation parameters based on the current electrode load response sequence; a reference stimulation control module for forming a front-end reference load segment, a candidate parameter action segment, an intra-segment reference load response, and a rear-end reference load segment; a load reference reconstruction module for reconstructing an electrode load reference sequence; a parameter response processing module for forming a candidate parameter response sequence and forming a parameter action response after double-end verification; and a stimulation parameter control module for determining a target stimulation parameter based on the parameter action response, the electrode load reference sequence, and the reference load segment, and generating a stimulation output control signal corresponding to the target stimulation parameter.

[0129] Each module is implemented by the controller 5 executing corresponding program instructions. The load response acquisition module forms the current electrode load response sequence, the adjustment parameter determination module determines the reference load segment, candidate adjustment position and candidate stimulation parameters, the reference stimulation control module completes the stimulation parameter switching and reference load response acquisition, the load reference reconstruction module forms the electrode load reference sequence, the parameter response processing module performs candidate parameter response processing and double-end verification, and the stimulation parameter control module determines the target stimulation parameter and converts it into a stimulation output control signal.

[0130] Although preferred embodiments of the invention have been described, those skilled in the art, upon learning the basic inventive concept, can make other changes and modifications to these embodiments. Therefore, the appended claims are intended to be interpreted as including both the preferred embodiments and all changes and modifications falling within the scope of the invention.

[0131] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback, characterized in that, Includes the following steps: Obtain the current stimulation parameters and the current electrode load response sequence arranged by stimulation pulse time. Based on the current electrode load response sequence, determine the baseline load segment before continuous offset, candidate adjustment positions, and candidate stimulation parameters. Before the candidate adjustment position, a front-end reference load segment is formed according to the current stimulus parameters. The candidate stimulus parameters are then switched to obtain the candidate load response and form the candidate parameter action segment. During this period, the current stimulus parameters are temporarily restored to obtain the intra-segment reference load response. After the candidate parameter action segment ends, the current stimulus parameters are restored to form the back-end reference load segment. The electrode load reference sequence corresponding to the candidate parameter action segment is reconstructed based on the front-end reference load segment, the intra-segment reference load response, and the back-end reference load segment. Candidate parameter response sequences are formed based on candidate load responses and electrode load reference sequences. The candidate parameter response sequences are then double-ended verified based on the responses before and after parameter switching at the inlet and outlet of the candidate parameter action segment to form the parameter action response. The target stimulation parameters are determined based on the parameter response, electrode load reference sequence, and baseline load segment, and the stimulation output control signal corresponding to the target stimulation parameters is generated.

2. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps to obtain the current electrode load response sequence are as follows: The stimulation pulse is output according to the current stimulation parameters, and the detection signal at the electrode output terminal is acquired based on the output time of the stimulation pulse. The detection signal at the electrode output is divided into pulse detection segments according to the stimulation pulse duration and recovery duration. The changes in the detection signal of the pulse detection segment during the stimulation pulse and the recovery period are analyzed to form a single-pulse electrode load response; The single-pulse electrode load responses are arranged according to the timing of the stimulation pulse to form the current electrode load response sequence.

3. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps for determining the baseline load segment, candidate modulation locations, and candidate stimulus parameters are as follows: Sequential analysis of the current electrode load response sequence determines the starting point at which the electrode load response begins to deviate continuously from the range of the previous continuous response. Select the continuous electrode load responses before the starting position to form a reference load segment, and connect the electrode load responses with the same offset direction and adjacent time from the starting position to form a candidate load change segment. When a candidate load change segment reaches a preset duration range, the corresponding position is determined as a candidate adjustment position; Based on the offset direction of the candidate load change segment and the correspondence between the preset load offset direction and the stimulus parameter adjustment direction, the stimulus parameter adjacent to the current stimulus parameter is selected from the preset stimulus parameter table to form the candidate stimulus parameter.

4. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps to create a front-end reference payload fragment are as follows: Using the candidate adjustment position as the end, extract the continuous electrode load response obtained according to the current stimulation parameters from the current electrode load response sequence. Determine a continuous response interval that is continuously connected to the candidate adjustment position and whose direction of change of load response of adjacent electrodes remains unchanged from the candidate adjustment position forward; The electrode load response within the continuous response interval is used to form a front-end reference load segment.

5. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps for forming candidate parameter action segments and intra-segment reference load responses are as follows: Switch from candidate modulation position to candidate stimulus parameter, continuously obtain candidate load response, and form candidate parameter action segment; After obtaining a preset number of candidate load responses, the current stimulus parameters are temporarily restored to obtain the first intra-segment reference load response, and then the candidate stimulus parameters are restored. Compare the variation range of the candidate load responses of two adjacent groups. If the variation range shows an increasing trend, shorten the interval for obtaining the reference load response within the segment. If the variation range shows a converging trend, extend the interval for obtaining the reference load response. The reference load response within the segment is repeatedly acquired at the adjusted acquisition interval. After each acquisition, the candidate stimulus parameters are restored until the segment in which the candidate parameters act ends.

6. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps to create a backend reference load segment are as follows: After the candidate parameter application period ends, the current stimulation parameter is restored, and the electrode load response is continuously obtained; Analyze the changing direction of the load response of adjacent electrodes starting from the first electrode load response; The electrode load responses with non-reversed direction of connection change and adjacent time form a back-end reference load segment.

7. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps for reconstructing the electrode load reference sequence are as follows: The electrode load response at the end of the front reference load segment, the reference load response within each segment, and the electrode load response at the beginning of the rear reference load segment are extracted and arranged according to the stimulation pulse time to form a reference load node sequence. The node interval where each candidate load response is located is determined based on adjacent reference load nodes; The corresponding reference load response is determined based on the time position of the candidate load response within the node interval and the response changes at both ends of the node interval. The reference load responses are arranged according to the timing of the stimulation pulses to form an electrode load reference sequence.

8. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps to form a parameter-driven response are as follows: Extract the electrode load response and the first candidate load response before switching at the entry point of the candidate parameter action segment, and correct the load change at the corresponding time according to the electrode load reference sequence to form the entry parameter response; Extract the last candidate load response at the exit of the candidate parameter action fragment and the first electrode load response after restoring the current stimulation parameter, and form the exit parameter response in the same way; The candidate load responses are analyzed in conjunction with the corresponding reference load responses to form a candidate parameter response sequence; The output parameter response is converted to the same parameter switching direction as the input parameter response. Based on the input parameter response and the converted output parameter response, response deviation analysis is performed on the input and output sides of the candidate parameter response sequence to form a two-end verification result. When the double-end verification results meet the preset allowable conditions, a parameter action response is generated. When the preset allowable conditions are not met, the front-end reference load segment, candidate parameter action segment, and back-end reference load segment are regenerated, and an intra-segment reference load response is added at the corresponding end. After updating the electrode load reference sequence, the double-end verification is repeated.

9. The method for adjusting stimulation parameters of an antiemetic device based on electrode load feedback according to claim 1, characterized in that, The steps to determine the target stimulus parameters are as follows: Obtain the reference load response at the end of the electrode load reference sequence, and form the current load offset based on its response change relative to the reference load segment; The current load offset is corrected based on the parameter response to form the remaining load offset; When the remaining load offset is within the preset allowable range, the candidate stimulus parameter is determined as the target stimulus parameter; When the remaining load offset exceeds the preset allowable range, a stimulus parameter adjacent to the candidate stimulus parameter is selected as a new candidate stimulus parameter according to the direction of the remaining load offset. The process of candidate parameter action fragment formation, reference load reconstruction and parameter action response formation is re-executed until the target stimulus parameter is determined.

10. A device for adjusting stimulation parameters of an antiemetic based on electrode load feedback, employing the method for adjusting stimulation parameters of an antiemetic based on electrode load feedback as described in any one of claims 1-9, characterized in that, include: The load response acquisition module is used to acquire the current stimulation parameters and the current electrode load response sequence; The adjustment parameter determination module is used to determine the baseline load segment, candidate adjustment positions, and candidate stimulation parameters based on the current electrode load response sequence. The reference stimulus control module is used to generate front-end reference load segments, candidate parameter action segments, intra-segment reference load responses, and back-end reference load segments. The load reference reconstruction module is used to reconstruct the electrode load reference sequence; The parameter response processing module is used to generate candidate parameter response sequences and verify them through two ends to form parameter action responses. The stimulation parameter control module is used to determine the target stimulation parameters based on the parameter response, electrode load reference sequence, and baseline load segment, and to generate the stimulation output control signal corresponding to the target stimulation parameters.

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