An adjustable multi-ratio drug mixing device and methods of use thereof

Abstract

The application relates to the technical field of medicine preparation equipment, and discloses a multiple-proportion medicine mixing device and a use method thereof, which comprises a barrel shell and a cover plate. A separate feeding mechanism is inserted into the barrel shell to realize multiple-material isolation and quantitative feeding. A separate sleeve is slidably connected to the top of the cover plate. The spiral pressure column in the separate sleeve is converted into rotary motion under pressure, drives the weight block to be deviated under the centrifugal force, and makes the silica gel column bend and expand into paddles for stirring. The bottom of the separate sleeve is connected with a concave piston block. After the extrusion discharging assembly is unlocked, the separate sleeve is pressed to drive the piston block to discharge. The inner recess at the bottom of the piston block can accommodate the stirring assembly in the contracted state to prevent residue. The use method comprises the following steps: assembling the bottom container according to the dosage form; inserting the separate mechanism to quantitatively feed and drawing out; locking the discharging assembly, pressing the spiral pressure column to centrifugally expand and stir; unlocking the discharging assembly for the ointment, pressing the piston block to discharge and accommodating the paddles. The application integrates the functions of quantitative feeding, centrifugal stirring and avoiding discharging.

Description

Technical Field

[0001] This invention relates to the field of drug preparation equipment technology, specifically to an adjustable multi-proportion drug mixing device and its usage method. Background Technology

[0002] In clinical medicine and pharmacy dispensing, it is often necessary to mix various powders or ointments in different proportions according to prescriptions. Existing drug mixing devices have certain structural limitations in actual use. In the initial feeding stage, the device has a single cavity structure, and operators need to use external instruments to weigh each drug separately before pouring them in one by one. The flow of multiple containers will cause material loss due to adhesion to the walls. If the same mixing container is continuously added directly, it is difficult to intuitively and accurately control the quantitative proportion of multiple components due to the lack of physical isolation.

[0003] In the material mixing and subsequent discharge stages, especially when handling highly viscous ointments, existing integrated mixing and discharge devices suffer from internal structural interference. These devices use a downward-pressing piston to extrude the mixed ointment, but the internal stirring rod or impeller is a rigid, outward-expanding structure that occupies part of the container's bottom volume. When the downward-pressing piston discharges, it cannot continue to descend to the bottom of the container due to the physical obstruction of the stirring components, resulting in a discharge dead zone at the bottom. This structural interference causes some of the mixed ointment to remain inside the container, leading to a waste of medical resources and affecting the accuracy of the actual drug dosage. Summary of the Invention

[0004] To address the shortcomings of existing technologies, this invention provides an adjustable multi-proportion drug mixing device and its usage method, which solves the problems of existing mixing devices being unable to isolate and quantitatively add materials in a single container, and the internal fixed stirring components obstructing the piston's downward movement, resulting in material residue during discharge.

[0005] To achieve the above objectives, the present invention provides the following technical solution: The first aspect of the present invention provides an adjustable multi-ratio drug mixing device, comprising: A container assembly includes a cylindrical shell, a bottom cylinder and a cover plate that are threaded to the bottom and top ends of the cylindrical shell, respectively; a holding sleeve that is fixedly connected to the top of the cover plate; and an isolation sleeve that is slidably connected to the inside of the cover plate and the holding sleeve. A stirring mechanism is disposed inside the insulating sleeve. The stirring mechanism includes a spiral pressure column that extends upwards beyond the holding sleeve. The stirring mechanism also includes a rotating sleeve, a spline column, a sliding ring, a bottom plate, a silicone column, and a weight block. The rotating sleeve is rotatably connected to the top of the inner side of the insulating sleeve. The spiral pressure column passes through and is threadedly connected to the inner side of the rotating sleeve. The spline column is drivenly connected to the rotating sleeve. The outer wall of the spline column is slidably connected to the sliding ring, and the bottom end is fixedly connected to the bottom plate. The two ends of the plurality of silicone columns are respectively rotatably connected to the sliding ring and the bottom plate, and the middle of the silicone column is fixedly connected to the weight block. The spiral pressure column and the rotating sleeve have a threaded transmission fit structure that converts linear movement into rotational motion. The weight block has a travel stroke that is offset outwards by centrifugal force when the spline column rotates. The silicone column has a deformation and unfolding space that is driven outwards by the weight block and pulls the sliding ring to slide downwards along the spline column.

[0006] Furthermore, a limiting rotating ring is rotatably connected to the bottom of the inner wall of the insulating sleeve, and the spline column slides through the middle of the limiting rotating ring; multiple linkage rods are fixedly connected to the outer side of the rotating sleeve, and the bottom ends of the multiple linkage rods are slidably connected to the limiting rotating ring; an auxiliary ring is fixedly connected to the outer side of the spiral pressure column, and a return spring is fixedly connected to the top of the limiting rotating ring, with the other end of the return spring fixedly connected to the auxiliary ring.

[0007] Furthermore, the auxiliary ring is composed of three rings that are rotatably connected in sequence, and the multiple linkage rods slide through the middle of the auxiliary ring; the return spring is sleeved inside the stirring mechanism, and its two ends abut against the limiting rotating ring and the auxiliary ring respectively, so as to provide elastic support force for axial reset and reverse rotation of the spiral pressure column.

[0008] Furthermore, stirring silicon wafers are fixedly connected to both sides of the outer wall of the silicone column; the stirring silicon wafers have a linkage structure that expands outward as the silicone column is bent by centrifugal force to increase the contact area.

[0009] Furthermore, the device also includes an extrusion discharge assembly disposed between the insulating sleeve and the holding sleeve; the extrusion discharge assembly includes a rotating locking ring rotatably connected to the top of the insulating sleeve, and semi-circular locking strips fixedly connected to both sides of the rotating locking ring; L-shaped locking plates are fixedly connected to both sides of the top of the holding sleeve, and a groove is provided on the top; the semi-circular locking strips have a first position for engaging with the L-shaped locking plates to axially position the insulating sleeve and the holding sleeve; and a second position for rotating above the groove to release the engagement and allow the insulating sleeve to slide towards the inner side of the cylinder shell.

[0010] Furthermore, the extrusion discharge assembly also includes a concave piston block rotatably connected to the bottom end of the insulating sleeve; multiple guide strips are fixedly connected to the inner wall of the cylinder shell at equal intervals, and a sliding groove corresponding to and engaging with the guide strips is provided on the outer side of the concave piston block; an inner groove is provided on the bottom inner side of the concave piston block, and the volume of the inner groove matches the total volume of the sliding ring, bottom plate and silicone column in the static contraction state, for accommodating the stirring mechanism when the insulating sleeve moves down to the bottom end.

[0011] Furthermore, the device also includes a separating and discharging mechanism, which is detachably inserted into the internal cavity of the cylindrical shell; the separating and discharging mechanism includes a central clamping cylinder and a plurality of laterally distributed dividing plates, one end of the dividing plate is inserted into a groove on the outside of the central clamping cylinder, and the other end of the dividing plate is provided with a slot on the outside, the slot being slidably inserted into the guide strip on the inner wall of the cylindrical shell.

[0012] Furthermore, the outer wall of the cylindrical shell is provided with scale lines; a pull ring is fixedly connected to the top of the central clamping cylinder.

[0013] Furthermore, the device also includes an alternative discharge mechanism for replacing the bottom cylinder and threadedly connected to the bottom end of the cylinder shell; the discharge mechanism includes a flexible tube and a drug outlet communicating with the bottom of the flexible tube.

[0014] A second aspect of the present invention provides a method of using the above-mentioned adjustable multi-ratio drug mixing device, comprising the following steps: S1: Assemble the bottom container according to the dosage form of the material; when mixing powder, connect the cylinder shell to the bottom cylinder by thread; when mixing ointment, connect the cylinder shell to the soft tube of the discharge mechanism by thread, and seal the drug outlet with a plug sleeve; S2: Place the separating and dispensing mechanism inside the cylindrical shell, align the slot with the guide strip and insert it; in conjunction with the scale lines on the outside of the cylindrical shell, add a measured amount of medicine to the independent areas separated by the dividing plate; pull the pull ring to remove the separating and dispensing mechanism; S3: Cover the top of the cylinder shell with the cover plate and the upper component, so that the outer side of the concave piston block engages with the guide strip; rotate the rotating engagement ring to the first position, so that the semi-arc strip engages with the L-shaped engagement plate and locks the isolation sleeve and the holding sleeve. S4: Press the spiral column back and forth along the axial direction, and drive the rotating sleeve and the spline column to rotate through the thread and spline transmission structure; the load block rotates accordingly and is offset outward by centrifugal force, causing the silicone column to bend and deform and pull the sliding ring down, and the silicone column and stirring silicon wafer unfold to stir the material; when the pressing force is removed, the reset spring releases potential energy to drive the mechanism to reset and cause reverse rotation stirring; S5: For ointment materials, after stirring, rotate the rotating locking ring to the second position to release the locking of the isolation sleeve; remove the stopper, press the spiral pressure column to drive the isolation sleeve to move down, and use the concave piston block to squeeze the material out of the drug outlet; during the stroke to the bottom, the silicone column and the sliding ring in the contracted state are simultaneously received into the inner groove of the concave piston block.

[0015] This invention provides an adjustable multi-ratio drug mixing device and its method of use. It has the following beneficial effects: 1. This invention employs a centrifugal deformation-type power conversion stirring structure. Pressing the spiral column converts linear displacement into rotational motion of the spline column via threaded transmission. The weight block is offset outward by centrifugal force, causing the silicone column to bend and unfold, and pulling the sliding ring downward to form stirring blades. When the pressing force is removed, the reset spring drive mechanism rotates in the opposite direction and the blades retract. Through linear input of a single shaft, the dynamic unfolding and alternating reverse stirring of the internal blades can be realized, improving the mixing efficiency of the reagents.

[0016] 2. The present invention is equipped with a dual-station switching and avoidance material discharge mechanism. After the rotating locking ring is released from the axial locking of the isolation sleeve, the isolation sleeve can drive the concave piston block to produce volumetric downward extrusion of ointment in the cylinder shell. The bottom of the concave piston block is provided with an inner groove. At the end of the piston's downward movement, the retracted silicone column and the sliding ring can be contained in the inner groove as a whole, freeing up the bottom discharge space and reducing the amount of high viscosity material residue at the bottom of the container.

[0017] 3. The present invention provides a detachable separating material feeding mechanism inside the cylindrical shell. By using the insertion and limiting of the dividing plate and the guide strip on the inner wall of the cylindrical shell, the internal cavity is divided into multiple physically isolated areas. Combined with the scale lines on the outer wall, it realizes the independent quantitative feeding of multiple materials in the same container. After the feeding is completed, the mechanism can be pulled out as a whole and enter the mixing process in situ, avoiding material loss caused by multiple external weighing and material transfer. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of an adjustable multi-proportion drug mixing device according to the present invention; Figure 2 This is a schematic diagram of the assembly structure of the material feeding mechanism and the cylinder shell of the present invention; Figure 3This is a schematic diagram of the bottom structure of the present invention after replacing the dispensing mechanism for ointment-type pharmaceuticals; Figure 4 This is a schematic diagram of the overall appearance of the upper stirring assembly and cover plate of the present invention; Figure 5 This is a schematic diagram of the internal cross-sectional structure of the upper stirring assembly and cover plate of the present invention; Figure 6 for Figure 5 A magnified schematic diagram of the partial structure at point A in the middle; Figure 7 This is a three-dimensional structural diagram of the holding sleeve of the present invention; Figure 8 This is a three-dimensional structural diagram of the centrifugal deformation component at the lower end of the stirring mechanism of the present invention.

[0019] The components include: 1. Cylinder shell; 2. Cover plate; 3. Bottom cylinder; 4. Separating and discharging mechanism; 41. Separating plate; 42. Slot; 43. Guide strip; 44. Central slot; 5. Discharge mechanism; 51. Soft tube; 52. Drug outlet; 6. Holding sleeve; 7. Isolating sleeve; 8. Stirring mechanism; 81. Spiral pressure column; 82. Rotating sleeve; 83. Linkage rod; 84. Auxiliary ring; 85. Limiting rotating ring; 86. Spline column; 87. Sliding ring; 88. Bottom plate; 89. Silicone column; 810. Weight block; 811. Stirring silicon wafer; 812. Return spring; 813. Extrusion discharge assembly; 8131. Rotating locking ring; 8132. Semi-arc locking strip; 8133. L-shaped locking plate; 8134. Groove; 8135. Concave piston block. Detailed Implementation

[0020] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] Example 1: Please see the appendix Figure 1 - Appendix Figure 8 This invention provides an adjustable multi-ratio drug mixing device and its usage method, including a container assembly, including a cylindrical shell 1, and a bottom cylinder 3 and a cover plate 2 respectively threadedly connected to the bottom and top ends of the cylindrical shell 1; a holding sleeve 6 fixedly connected to the top of the cover plate 2; and an isolation sleeve 7 slidably connected to the inner side of the cover plate 2 and the holding sleeve 6. The stirring mechanism 8 is located inside the insulating sleeve 7. The stirring mechanism 8 includes a spiral pressure column 81 that extends upward out of the holding sleeve 6. The stirring mechanism 8 also includes a rotating sleeve 82, a spline column 86, a sliding ring 87, a bottom plate 88, a silicone column 89, and a weight block 810. The rotating sleeve 82 is rotatably connected to the top of the inner side of the insulating sleeve 7, and the spiral pressure column 81 passes through and is threadedly connected to the inner side of the rotating sleeve 82. The spline column 86 is connected to the rotating sleeve 82 via a transmission connection; a sliding ring 87 is slidably connected to the outer wall of the spline column 86, and a bottom plate 88 is fixedly connected to the bottom end; the two ends of multiple silicone columns 89 are rotatably connected to the sliding ring 87 and the bottom plate 88 respectively, and a load block 810 is fixedly connected to the middle of the silicone column 89; the spiral pressure column 81 and the rotating sleeve 82 have a threaded transmission fit structure that converts linear movement into rotational motion; the load block 810 has an active stroke that shifts outward due to centrifugal force when the spline column 86 rotates, and the silicone column 89 has a deformation and unfolding space that is driven by the load block 810 to bend outward and pull the sliding ring 87 to slide downward along the spline column 86.

[0022] Specifically, in a static state without external pressure, the silicone column 89 maintains a vertical position due to its own elastic support force. In the static state, the sliding ring 87 is at the highest point of the outer wall of the spline column 86, and the bottom stirring component has a contracted columnar shape. When the operator presses the spiral pressure column 81 from top to bottom, the axial linear motion of the spiral pressure column 81 drives the rotating sleeve 82 to rotate through the surface thread structure, thereby driving the spline column 86 to rotate synchronously. Under the action of centrifugal force generated by rotation, the load block 810 shifts outward, overcoming the original vertical static support force of the silicone column 89, causing the silicone column 89 to bend outward. During the bending deformation of the silicone column 89, the upper end of the silicone column 89 pulls the sliding ring 87 downward and slides down along the outer wall of the spline column 86 to compensate for the deformation stroke. In the unfolded state, the outwardly bent silicone column 89 forms a stirring blade profile with a large radial dimension, mixing the agent inside the shell 1. A limiting ring 85 is rotatably connected to the bottom of the inner wall of the insulating sleeve 7, and a splined column 86 is slidably inserted through the middle of the limiting ring 85; multiple linkage rods 83 are fixedly connected to the outer side of the rotating sleeve 82, and the bottom ends of the multiple linkage rods 83 are slidably connected to the limiting ring 85; an auxiliary ring 84 is fixedly connected to the outer side of the spiral pressure column 81, and a return spring 812 is fixedly connected to the top of the limiting ring 85, and the other end of the return spring 812 is fixedly connected to the auxiliary ring 84; the auxiliary ring 84 is composed of three rings rotatably connected in sequence, and the multiple linkage rods 83 slide through the ring in the middle of the auxiliary ring 84; the return spring 812 is sleeved inside the stirring mechanism 8, and the two ends of the return spring 812 abut against the limiting ring 85 and the auxiliary ring 84 respectively, so as to provide elastic support force for axial reset and reverse rotation of the spiral pressure column 81; Specifically, the rotating sleeve 82, the linkage rod 83, the limiting rotating ring 85, and the spline column 86 with a spline groove structure together constitute a synchronous rotary transmission assembly; the auxiliary ring 84 adopts a three-ring rotating connection structure, which allows the inner and outer rings to rotate relative to each other while the middle ring is guided by the linkage rod 83, thereby decoupling the rotary motion from the axial motion. When the spiral pressure column 81 is pressed down, the spiral pressure column 81 drives the auxiliary ring 84 to move down synchronously, compressing the bottom return spring 812 so that the return spring 812 absorbs and stores elastic potential energy; when the operator removes the pressing force applied to the top of the spiral pressure column 81, the return spring 812 releases potential energy and pushes the auxiliary ring 84 upward, driving the spiral pressure column 81 to return to its original position; due to the threaded fit between the spiral pressure column 81 and the rotating sleeve 82, the upward displacement of the spiral pressure column 81 will drive the rotating sleeve 82 and the spline column 86 to rotate in the opposite direction; the above transmission structure allows the unidirectional reciprocating pressing operation to be converted into the alternating forward and reverse rotation of the internal stirring component; at the same time, as the rotation speed decreases, the centrifugal force decreases, the silica gel column 89 returns to vertical, and the sliding ring 87 moves up and returns to its original position.

[0023] Stirring silicon wafers 811 are fixedly connected to both sides of the outer wall of the silicone column 89; the stirring silicon wafers 811 have a linkage structure that expands outward as the silicone column 89 is bent by centrifugal force to increase the contact area. Specifically, the stirring silicon wafer 811 serves as an additional contact surface, close to the central axis when the silicone column 89 is in a static vertical state; when the silicone column 89 is bent and unfolded by centrifugal force, the stirring silicon wafer 811 is pushed outward accordingly, increasing the physical contact area between the impeller and the internal agent.

[0024] It also includes an extrusion discharge assembly 813 disposed between the insulating sleeve 7 and the holding sleeve 6; the extrusion discharge assembly 813 includes a rotating locking ring 8131 rotatably connected to the top of the insulating sleeve 7, and semi-circular locking strips 8132 fixedly connected to both sides of the rotating locking ring 8131; L-shaped locking plates 8133 are fixedly connected to both sides of the top of the holding sleeve 6, and a groove 8134 is provided on the top; the semi-circular locking strips 8132 have a first position for engaging with the L-shaped locking plates 8133 to axially position the insulating sleeve 7 and the holding sleeve 6; and a position for rotating above the groove 8134 to release the engagement and allow the insulating sleeve 7 to be axially positioned. The sleeve 7 has a second station with a sliding stroke towards the inside of the cylinder shell 1; the extrusion discharge assembly 813 also includes a concave piston block 8135 rotatably connected to the bottom end of the insulating sleeve 7; a plurality of guide strips 43 are fixedly connected to the inner wall of the cylinder shell 1 at equal intervals; the outer side of the concave piston block 8135 is provided with a sliding groove that engages with the guide strips 43; the bottom of the inner side of the concave piston block 8135 is provided with an inner groove, the volume of which matches the total volume of the sliding ring 87, the bottom plate 88 and the silicone column 89 in the static contraction state, for wrapping the stirring mechanism 8 when the insulating sleeve 7 moves down to the bottom end; Specifically, the extrusion discharge assembly 813 is mainly used for the discharge process after the viscous agent is mixed. During mixing, the rotating locking ring 8131 is in the first position, and the semi-circular locking strip 8132 is engaged with the lower side of the L-shaped locking plate 8133, so that the isolation sleeve 7 and the outer holding sleeve 6 are rigidly fixed. The pressing operation only triggers the rotation of the stirring mechanism 8. When discharge is required, the operator manually rotates the rotating locking ring 8131 to the second position, the semi-circular locking strip 8132 disengages from the L-shaped locking plate 8133 and aligns with the groove 8134, releasing the axial lock of the isolation sleeve 7. Subsequently, the extended spiral pressure column 81 is pressed down, and the pressure is transmitted through the isolation sleeve 7 to the concave piston block 8135 at the bottom. The sliding groove of block 8135 slides down along the guide strip 43 on the inner wall of the cylindrical shell 1, forming a piston compression effect with volume change inside the cylindrical shell 1, pushing the mixed agent downward to be discharged; when the concave piston block 8135 is pressed down to the end stroke near the bottom of the cylindrical shell 1, the stirring components such as the silicone column 89, sliding ring 87 and bottom plate 88, which are in a static contraction state, pass through the bottom opening of the concave piston block 8135 and are completely contained in the inner groove of the concave piston block 8135; the above-mentioned inner groove containing structure avoids the stirring components occupying the bottom space and reduces the amount of high viscosity agent remaining at the bottom inside the cylindrical shell 1.

[0025] Example 2: See appendix Figure 2 In conjunction with an adjustable multi-ratio drug mixing device of Example 1, this further discloses a dispensing structure for the isolated and quantitative dispensing of multi-component drugs; In this embodiment, the mixing device further includes a separating and discharging mechanism 4, which is detachably inserted into the internal cavity of the cylindrical shell 1. The separating and discharging mechanism 4 includes a central clamping cylinder 44 and a plurality of laterally distributed dividing plates 41. One end of the dividing plate 41 is inserted into a groove on the outside of the central clamping cylinder 44, and a slot 42 is provided on the outside of the other end of the dividing plate 41. The slot 42 is slidably inserted into the guide strip 43 on the inner wall of the cylindrical shell 1. The outer wall of the cylindrical shell 1 is provided with scale lines; a pull ring is fixedly connected to the top of the central retaining cylinder 44; Specifically, the separating and discharging mechanism 4 provides physical isolation and quantitative reference structure before the reagent is mixed; in actual operation, the bottom cylinder 3 or the discharging mechanism 5 is threadedly connected to the bottom end of the cylinder shell 1 to seal the bottom end of the cylinder shell 1; then, the central clamping cylinder 44, which is pre-inserted with multiple dividing plates 41, is inserted into the internal cavity of the cylinder shell 1 from top to bottom; during the insertion and downward movement of the central clamping cylinder 44, the groove 42 on the outside of the dividing plate 41 slides along the guide strip 43 on the inner wall of the cylinder shell 1, and the cooperation between the guide strip 43 and the groove 42 plays a role in radial limiting and guiding, and makes the outer edge of the dividing plate 41 close to the inner wall of the cylinder shell 1; at this time, the central clamping cylinder 44 and the multiple dividing plates 41 form multiple independent fan-shaped feeding areas that are not interconnected inside the cylinder shell 1; After the area is divided, the user, in accordance with the scale lines set on the outer wall of the cylinder shell 1, adds different types and proportions of agents to each independent feeding area in a quantitative manner. During the agent feeding stage, different types of agents are physically isolated by the dividing plate 41 and the central clamping cylinder 44, which avoids non-quantitative premature contact or proportional interference of multiple materials during the feeding stage. After all the reagents in the independent areas have been added according to the scale lines, pull the pull ring on the top of the central clamp 44 upwards, causing the entire separating and discharging mechanism 4 to move upwards along the trajectory of the guide strip 43 and be pulled out of the cylinder shell 1. After the separating and discharging mechanism 4 is pulled out, the previously isolated reagents naturally fall into the same space at the bottom of the cylinder shell 1 under the action of gravity and converge. Then, cover the top of the cylinder shell 1 with the cover plate 2 and the stirring mechanism 8 connected to the inside of the cover plate 2 to enter the subsequent mechanical mixing process. The separating and discharging mechanism 4 replaces the traditional external multi-container separate weighing step by dividing the volume inside the cylinder shell 1, reducing the loss of reagents when transferring and pouring between multiple containers.

[0026] Example 3: See appendix Figure 3 In conjunction with an adjustable multi-proportion drug mixing device of Example 1, this device is designed to adapt to the mixing and discharge of high-viscosity drugs. In this embodiment, the mixing device also includes an alternative discharge mechanism 5, which is used to replace the bottom cylinder 3 and is threadedly connected to the bottom end of the cylinder shell 1; the discharge mechanism 5 includes a flexible tube 51 and a drug outlet 52 connected to the bottom of the flexible tube 51. Specifically, for ointments or other drugs with poor flowability, the conventional method of opening and pouring will leave drug residue at the bottom of the container; before mixing ointment drugs, the soft tube 51 of the discharge mechanism 5 is threaded to the bottom end of the cylinder shell 1 to seal the bottom opening of the cylinder shell 1, and the drug outlet 52 is temporarily sealed with an external plug. After assembly, the interior of the cylindrical shell 1 and the soft tube 51 together form the mixing chamber for the ointment. After the ointment is mixed by the internal stirring component, the plug on the outside of the drug outlet 52 is removed. At this time, in conjunction with the extrusion discharge component 813 in Example 1, the concave piston block 8135 applies piston extrusion thrust from top to bottom towards the inside of the cylindrical shell 1. Under the action of the extrusion thrust, the mixed ointment is compressed and guided along the inner wall of the bottom constricted soft tube 51, and finally directionally extruded from the bottom tubular drug outlet 52. The discharge mechanism 5 changes the bottom flat storage structure to a constricted tube structure with flow guiding discharge characteristics. Combined with the downward extrusion action of the piston at the top, it solves the problem of residual high-viscosity drugs after mixing.

[0027] The method of using an adjustable multi-ratio drug mixing device described below is consistent with the method of using an adjustable multi-ratio drug mixing device described above.

[0028] S1: Assemble the bottom container according to the drug dosage form; if it is a mixed powder drug, thread the cylinder shell 1 to the bottom cylinder 3; if it is a mixed ointment drug, thread the cylinder shell 1 to the soft tube 51 of the discharge mechanism 5, and use a plug sleeve to seal the drug outlet 52. S2: Place the separating and discharging mechanism 4 into the cylinder shell 1, and insert the slot 42 into the guide strip 43; use the dividing plate 41 in conjunction with the outer scale line to quantitatively add different agents to the multiple independent areas that are separated; after the feeding is completed, pull the pull ring to pull out the separating and discharging mechanism 4 as a whole. S3: Cover the top of the cylinder shell 1 with the cover plate 2 and the upper component, so that the outer side of the concave piston block 8135 engages with the guide strip 43; then rotate the rotating engagement ring 8131 to the first position, so that the semi-arc strip 8132 engages with the L-shaped engagement plate 8133 and is fixed, so that the isolation sleeve 7 and the holding sleeve 6 form a rigid connection. S4: Press the spiral pressure column 81 repeatedly downwards, and the rotating sleeve 82 and spline column 86 will rotate through the internal thread and spline transmission; the weight block 810 will be thrown out by centrifugal force, causing the silicone column 89 to bend and deform and pull the sliding ring 87 to move down, forming an unfolded paddle to mix and stir the medicine; when the press is released, the potential energy is released through the reset spring 812 to cause the paddle to contract and rotate in the opposite direction to stir; S5: If it is an ointment, after stirring, rotate the locking ring 8131 in the opposite direction to the second position, so that the semi-circular locking strip 8132 rotates to the top of the groove 8134 to release the engagement; remove the plug of the drug outlet 52, press the spiral pressure column 81 again to drive the isolation sleeve 7 to press down as a whole, so that the concave piston block 8135 squeezes the mixed drug out of the drug outlet 52; when pressed to the bottom, the silicone column 89 and the sliding ring 87 in the contracted state are wrapped in the groove inside the concave piston block 8135.

[0029] The method in this embodiment can be used to execute the above-described device embodiment, and its principle and technical effects are similar, so they will not be repeated here.

[0030] Working principle: In the initial stage of the mixing operation, the separating and discharging mechanism 4 is inserted into the cylindrical shell 1; the dividing plate 41 and the central clamping cylinder 44 divide the inside of the cylindrical shell 1 into multiple non-interconnected feeding areas; referring to the scale lines on the outer wall of the cylindrical shell 1, the agent is injected into each feeding area respectively; each feeding area is physically isolated by the dividing plate 41 to prevent different agents from contacting each other during the injection stage; after the injection is completed, the pull ring is pulled upward and the separating and discharging mechanism 4 is pulled out, and the agents in different areas fall into the bottom of the cylindrical shell 1 and converge under the action of gravity; During the mixing stage, the cover plate 2 and the stirring mechanism 8 are assembled. The rotating locking ring 8131 is rotated to the first position, so that the semi-circular locking strip 8132 on the outer side of the rotating locking ring 8131 engages with the L-shaped locking plate 8133, thereby restricting the axial sliding of the isolation sleeve 7 along the holding sleeve 6. Then, the spiral pressure column 81 is pressed down, and the spiral pressure column 81 drives the rotating sleeve 82 and the spline column 86 to rotate synchronously through the surface thread. The rotational motion of the spline column 86 generates centrifugal force, which drives the load block 810 in the middle of the silicone column 89 to shift away from the central axis. The shifted load block 810 pulls the silicone column 89 to bend outward. During the bending deformation process, the sliding ring 87 slides down along the outer wall of the spline column 86. At this time, the silicone column 89 and the stirring silicon wafer 811 form a radially unfolded profile, cutting and mixing the agent in the cylindrical shell 1. During the downward movement of the spiral pressure column 81, the spiral pressure column 81 drives the auxiliary ring 84 to press the reset spring 812 downward; after the pressing force is released, the reset spring 812 generates an upward elastic restoring force, pushing the auxiliary ring 84 and the spiral pressure column 81 upward to reset; due to the limitation of the threaded transmission, the upward movement of the spiral pressure column 81 drives the rotating sleeve 82 and the spline column 86 to rotate in opposite directions; as the rotation speed decreases and the centrifugal force decreases, the silicone column 89 retracts to a vertical state by relying on the material's own deformation restoring force, while pulling the sliding ring 87 upward to reset; by continuously pressing the spiral pressure column 81, the stirring mechanism 8 is able to rotate alternately in both directions and the radial dimension is periodically expanded and contracted; During the discharge stage, the rotating locking ring 8131 is rotated in the opposite direction to the second station. The semi-arc locking strip 8132 rotates out the L-shaped locking plate 8133 and aligns with the groove 8134 on the top of the holding sleeve 6, releasing the axial positioning constraint of the isolation sleeve 7. The spiral pressure column 81 is pressed down, and the thrust is transmitted through the isolation sleeve 7 to the concave piston block 8135 at the bottom. The concave piston block 8135 slides down along the guide strip 43 on the inner wall of the cylinder shell 1, compressing the volume inside the cylinder shell 1 and discharging the mixed agent by itself. The drug is extruded through the drug outlet 52 at the bottom of the feeding mechanism 5; when the concave piston block 8135 descends to the bottom end of the cylindrical shell 1, the silicone column 89, sliding ring 87 and bottom plate 88, which are in a vertically contracted state, pass through the opening at the bottom of the concave piston block 8135 and enter the inner groove on the inner side of the concave piston block 8135; this structure avoids the stirring mechanism 8 from interfering with the downward stroke of the concave piston block 8135, so that the concave piston block 8135 completes the mechanical extrusion of the drug at the bottom of the cylindrical shell 1.

[0031] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. An adjustable multi-proportion drug mixing device, characterized in that, include: The container assembly includes a cylindrical shell (1), a bottom cylinder (3) and a cover plate (2) which are threaded to the bottom and top ends of the cylindrical shell (1), respectively. The holding sleeve (6) is fixedly connected to the top of the cover plate (2); The insulating sleeve (7) is slidably connected to the inside of the cover plate (2) and the holding sleeve (6); A stirring mechanism (8) is disposed inside the insulating sleeve (7). The stirring mechanism (8) includes a spiral pressure column (81) that extends upward out of the holding sleeve (6). The stirring mechanism (8) also includes a rotating sleeve (82), a spline column (86), a sliding ring (87), a bottom plate (88), a silicone column (89), and a weight block (810). The rotating sleeve (82) is rotatably connected to the top of the inner side of the insulating sleeve (7). The spiral pressure column (81) passes through and is threadedly connected to the inner side of the rotating sleeve (82). The spline column (86) is drivenly connected to the rotating sleeve (82). The outer wall of the spline column (86) is slidably connected to the sliding ring (87), and the bottom end is fixedly connected to the bottom plate (88). The two ends of the plurality of silicone columns (89) are rotatably connected to the sliding ring (87) and the bottom plate (88), respectively, and the middle part of the silicone column (89) is fixedly connected to the weight block (810). The spiral pressure column (81) and the rotating sleeve (82) have a threaded transmission fit structure that converts linear movement into rotational motion; the load block (810) has an active stroke that is offset outward by centrifugal force when the spline column (86) rotates; the silicone column (89) has a deformation unfolding space that is driven outward by the load block (810) and pulls the sliding ring (87) to slide downward along the spline column (86).

2. The adjustable multi-ratio drug mixing device according to claim 1, characterized in that, The inner wall bottom of the insulating sleeve (7) is rotatably connected to a limiting ring (85), and the spline column (86) slides through the middle of the limiting ring (85); the outer side of the rotating sleeve (82) is fixedly connected to a plurality of linkage rods (83), and the bottom ends of the plurality of linkage rods (83) are slidably connected to the limiting ring (85); the outer side of the spiral pressure column (81) is fixedly connected to an auxiliary ring (84), and the top of the limiting ring (85) is fixedly connected to a return spring (812), and the other end of the return spring (812) is fixedly connected to the auxiliary ring (84).

3. The adjustable multi-ratio drug mixing device according to claim 2, characterized in that, The auxiliary ring (84) is composed of three rings that are rotatably connected in sequence, and the multiple linkage rods (83) slide through the middle of the auxiliary ring (84); the reset spring (812) is sleeved inside the stirring mechanism (8), and its two ends abut against the limiting rotating ring (85) and the auxiliary ring (84) respectively, so as to provide elastic support force for axial reset and reverse rotation of the spiral pressure column (81).

4. The adjustable multi-ratio drug mixing device according to claim 1, characterized in that, Stirring silicon wafers (811) are fixedly connected to both sides of the outer wall of the silicone column (89); the stirring silicon wafers (811) have a linkage structure that expands outward as the silicone column (89) is bent by centrifugal force to increase the contact area.

5. The adjustable multi-ratio drug mixing device according to claim 1, characterized in that, It also includes an extrusion discharge assembly (813) disposed between the isolation sleeve (7) and the holding sleeve (6). The extrusion discharge assembly (813) includes a rotating locking ring (8131) rotatably connected to the top of the isolation sleeve (7), and a semi-circular locking strip (8132) is fixedly connected to both sides of the rotating locking ring (8131); an L-shaped locking plate (8133) is fixedly connected to both sides of the top of the holding sleeve (6), and a groove (8134) is provided on the top. The semi-arc retainer (8132) has a first position that engages with the L-shaped retaining plate (8133) to axially position the insulating sleeve (7) and the holding sleeve (6); and a second position that rotates above the groove (8134) to release the engagement and allow the insulating sleeve (7) to slide inward toward the inner side of the cylindrical shell (1).

6. The adjustable multi-ratio drug mixing device according to claim 5, characterized in that, The extrusion discharge assembly (813) also includes a concave piston block (8135) rotatably connected to the bottom end of the isolation sleeve (7). The inner wall of the cylindrical shell (1) is equidistantly connected with a plurality of guide strips (43), and the outer side of the concave piston block (8135) is provided with a sliding groove that engages with the guide strips (43). The concave piston block (8135) has an inner groove at its inner bottom. The volume of the inner groove matches the total volume of the sliding ring (87), bottom plate (88), and silicone column (89) in the static contraction state. This groove is used to wrap the stirring mechanism (8) when the isolation sleeve (7) moves down to the bottom.

7. The adjustable multi-ratio drug mixing device according to claim 6, characterized in that, It also includes a separating material dispensing mechanism (4), which is detachably inserted into the internal cavity of the cylindrical shell (1); The separating feeding mechanism (4) includes a central clamping cylinder (44) and a plurality of laterally distributed dividing plates (41). One end of the dividing plate (41) is inserted into a groove on the outside of the central clamping cylinder (44), and a slot (42) is provided on the outside of the other end of the dividing plate (41). The slot (42) is slidably inserted into the guide strip (43) on the inner wall of the cylinder shell (1).

8. The adjustable multi-ratio drug mixing device according to claim 7, characterized in that, The outer wall of the cylindrical shell (1) is provided with scale lines; a pull ring is fixedly connected to the top of the central clamping cylinder (44).

9. The adjustable multi-ratio drug mixing device according to claim 1, characterized in that, The device also includes an alternative discharge mechanism (5) for replacing the bottom cylinder (3) and threadedly connected to the bottom end of the cylinder housing (1); the discharge mechanism (5) includes a soft tube (51) and a drug outlet (52) communicating with the bottom of the soft tube (51).

10. A method of using an adjustable multi-proportion drug mixing device, characterized in that, Using the adjustable multi-ratio drug mixing device as described in any one of claims 1-9 includes the following steps: S1: Assemble the bottom container according to the drug dosage form; if it is a mixed powder drug, thread the cylinder shell (1) to the bottom cylinder (3); if it is a mixed ointment drug, thread the cylinder shell (1) to the soft tube (51) of the discharge mechanism (5), and use a plug sleeve to seal the drug outlet (52); S2: Place the separating material dispensing mechanism (4) into the cylindrical shell (1), and insert the slot (42) into the guide strip (43); use the dividing plate (41) in conjunction with the outer scale line to quantitatively add different agents to the multiple independent areas that are separated; after the material is added, pull the pull ring to pull out the separating material dispensing mechanism (4) as a whole; S3: Cover the top of the cylindrical shell (1) with the cover plate (2) and the upper component, so that the outer side of the concave piston block (8135) engages with the guide strip (43); then rotate the rotating engagement ring (8131) to the first position, so that the semi-arc strip (8132) engages with the L-shaped engagement plate (8133) and is fixed, so that the isolation sleeve (7) and the holding sleeve (6) form a rigid connection; S4: Press the spiral pressure column (81) repeatedly downwards, and the rotating sleeve (82) and the spline column (86) will rotate through the internal thread and spline transmission; the weight block (810) will be thrown out by centrifugal force, causing the silicone column (89) to bend and deform and pull the sliding ring (87) downwards, forming an unfolded blade to mix and stir the medicine; when the pressing is released, the potential energy is released through the reset spring (812) to cause the blade to contract and rotate in the opposite direction to stir; S5: If it is an ointment, after stirring, rotate the rotating locking ring (8131) in the opposite direction to the second position, so that the semi-circular locking strip (8132) is rotated above the groove (8134) to release the fastening; remove the plug of the drug outlet (52), press the spiral pressure column (81) again to drive the isolation sleeve (7) to press down as a whole, so that the concave piston block (8135) squeezes the mixed drug out of the drug outlet (52); when pressed down to the bottom, the silicone column (89) and the sliding ring (87) in the contracted state are wrapped in the groove inside the concave piston block (8135).

Images