Cd197 hapten and antibodies specific thereto and uses
CN122978263APending Publication Date: 2026-10-27SHENZHEN HUADA GENE INST
Patent Information
- Application Number
- CN202510485536.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-04-16
- Publication Date
- 2026-10-27
AI Technical Summary
Benefits of technology
[0021]综上，本发明提供了一种新的半抗原，获得了能够特异性结合所述半抗原的抗CD197单克隆抗体或其抗原结合片段，其仅与CD197+细胞结合，与不表达CD197的细胞不结合，并且能从CD197+细胞占比较少的细胞类型中检测到CD197+细胞表达，表现出高特异性、高灵敏度、高准确度、和更好的信号强度。可通过直接使用或结合各种标记为的多种疾病的检测和治疗提供了一种灵敏且特异的方案。
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Figure CN122978263A_ABST
Abstract
The present application relates to a hapten or its application, more particularly to a hapten as shown in SEQ ID NO: 44, a conjugated antigen comprising the hapten, an antibody or an antigen-binding fragment thereof capable of specifically binding to the hapten or the conjugated antigen, a nucleic acid molecule encoding the antibody or the antigen-binding fragment thereof, a vector and an expression cell comprising the nucleic acid molecule, an antibody conjugate comprising the antibody or the antigen-binding fragment thereof, a kit and a drug, and their related applications for detection or treatment. + The antibody of the present application can specifically bind to CD197 cells with high accuracy and high specificity, opening up a new way for the treatment and diagnosis of tumors and other related diseases.
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Citation Information
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