An antioxidant moisturizing and water-locking contact lens care solution and a preparation method thereof

Abstract

The application belongs to the technical field of eye care products, and particularly relates to an antioxidant moisturizing and water-locking contact lens maintenance solution and a preparation method thereof. The antioxidant moisturizing and water-locking contact lens maintenance solution provided by the application contains the following components in a total mass of 1000 parts: 0.05-3 parts of a moisturizing lubricant, 0.001-0.003 parts of a preservative, 6-9 parts of a buffer, 5-8 parts of an osmotic pressure regulator, 0.1-1 parts of a chelating agent, 0.1-5 parts of a stabilizer, and the rest is water; the moisturizing lubricant is sodium hyaluronate and polyvinylpyrrolidone; and the stabilizer is ergothioneine. The antioxidant moisturizing and water-locking contact lens maintenance solution provided by the application can inhibit the degradation of active ingredients while lubricating and water-locking.

Description

Technical Field

[0001] This invention belongs to the field of eye care products technology, specifically relating to an antioxidant, moisturizing, and water-locking contact lens care solution and its preparation method. Background Technology

[0002] Current contact lens care products have poor moisturizing, lubricating, and water-locking abilities. Prolonged wear leads to rapid moisture loss, easily causing dry eyes, foreign body sensation, and blurred vision. Long-term use can also exacerbate corneal dryness and damage. Furthermore, the active ingredients in existing contact lens care products are prone to degradation, generating reactive oxygen species (ROS). These ROS accelerate lens aging and yellowing, continuously damage corneal epithelial cells, disrupt the ocular surface barrier, and increase the risk of conjunctivitis. Summary of the Invention

[0003] The purpose of this invention is to provide an antioxidant, moisturizing, and water-locking contact lens solution and its preparation method. The antioxidant, moisturizing, and water-locking contact lens solution provided by this invention can lubricate and lock in moisture, while simultaneously inhibiting the degradation of active ingredients and scavenging free radicals.

[0004] To achieve the above objectives, the present invention provides the following technical solution: An antioxidant, moisturizing, and water-locking contact lens care solution, based on a total mass of 1000 parts, comprises the following components: 0.05-3 parts of moisturizing lubricant, 0.001-0.003 parts of preservative, 6-9 parts of buffer, 5-8 parts of osmotic pressure regulator, 0.1-1 part of chelating agent, 0.1-5 parts of stabilizer, and the balance being water; wherein the moisturizing lubricant is sodium hyaluronate and polyvinylpyrrolidone; and the stabilizer is ergothioneine.

[0005] Preferably, the moisturizing lubricant, by weight, comprises: 0.05-1 parts sodium hyaluronate and 0.1-2 parts polyvinylpyrrolidone; and the stabilizer comprises 0.3-4 parts.

[0006] Preferably, the moisturizing lubricant, by weight, comprises: 0.05-0.5 parts sodium hyaluronate and 0.1-0.5 parts polyvinylpyrrolidone; and the stabilizer comprises 0.5-3 parts.

[0007] Preferably, the preservative is one or more of polyhexamethylene biguanide, polyquaternium salt, and sodium chlorite.

[0008] Preferably, the buffer is one or more of sodium dihydrogen phosphate-disodium hydrogen phosphate, tromethamine-hydrochloric acid, and boric acid-borax.

[0009] Preferably, the osmotic pressure regulator is sodium chloride and / or potassium chloride.

[0010] Preferably, the chelating agent is one or both of disodium ethylenediaminetetraacetate and sodium citrate.

[0011] Preferably, the osmotic pressure of the antioxidant, moisturizing, and water-locking contact lens care solution is 260~340 mOsm / Kg.

[0012] Preferably, the pH value of the antioxidant moisturizing and water-locking contact lens care solution is 6.5~7.8.

[0013] This invention provides a method for preparing the antioxidant, moisturizing, and water-locking contact lens care solution described above, comprising the following steps: The components of the antioxidant moisturizing and water-locking contact lens solution are mixed to obtain the antioxidant moisturizing and water-locking contact lens solution.

[0014] The antioxidant, moisturizing, and water-locking contact lens solution provided by this invention uses sodium hyaluronate and polyvinylpyrrolidone as moisturizing lubricants. Sodium hyaluronate provides immediate moisturizing, while polyvinylpyrrolidone locks in moisture. Sodium hyaluronate and polyvinylpyrrolidone work synergistically to enhance the moisturizing effect. This invention also uses ergothioneine as a stabilizer to stabilize the components, maintain the water-locking ability of the moisturizing lubricant, and chelate Fe. 2+ / Cu 2+ The presence of metal ions helps protect the moisturizer; at the same time, ergothioneine, as a free radical scavenger, can eliminate free radicals and inhibit the degradation of active ingredients in the formula, reducing the potential irritation of raw materials to ocular surface cells.

[0015] This invention constructs a complete eye care ecosystem. Sodium hyaluronate, polyvinylpyrrolidone, and ergothione in the formula all have high safety and excellent biocompatibility with eye tissues. The formula is gentle and, through the immediate moisturizing function of sodium hyaluronate, the water-locking function of polyvinylpyrrolidone, and the stabilizing function of ergothione, as well as the function of inhibiting the degradation of active ingredients in the formula, the antioxidant moisturizing and water-locking contact lens solution has active protection and anti-irritation functions. It can simultaneously address discomfort during contact lens wear from three levels: lubrication, water locking, and ingredient stabilization, providing a comprehensive and lasting comfortable experience.

[0016] After using the antioxidant moisturizing and water-locking contact lens care solution provided by this invention, the wearer can simultaneously experience an immediate lubrication, a long-lasting moisturizing comfort, and a deep sense of soothing and reassurance, achieving a comprehensive comfort experience from the physical to the biological level. This greatly reduces the potential risk of product irritation to sensitive eyes and is suitable for a wide range of people who need to wear contact lenses for a long time or daily, including users whose eyes are prone to sensitivity or dryness.

[0017] Vitamin C is unstable under light, in solution, and at high temperatures (40°C) and has poor heat and light resistance, making it unsuitable for stable use in antioxidant, moisturizing, and water-locking contact lens solutions. These solutions require an active ingredient content of 80%-120% within their shelf life (typically 2-3 years). Vitamin C cannot be stored for extended periods and may even degrade completely within a month. Therefore, vitamin C does not meet the requirements of this invention's antioxidant, moisturizing, and water-locking contact lens solution. This invention adds only ergothioneine, which satisfies the antioxidant performance requirements and also provides good product stability. Detailed Implementation

[0018] In this invention, unless otherwise specified, all raw materials / components used in the preparation are commercially available products well known to those skilled in the art.

[0019] This invention provides an antioxidant, moisturizing, and water-locking contact lens care solution, comprising the following components in a total mass fraction of 1000 parts: 0.05-3 parts of moisturizing lubricant, 0.001-0.003 parts of preservative, 6-9 parts of buffer, 5-8 parts of osmotic pressure regulator, 0.1-1 part of chelating agent, 0.1-5 parts of stabilizer, and the balance being water; wherein the moisturizing lubricant is sodium hyaluronate and polyvinylpyrrolidone; and the stabilizer is ergothioneine.

[0020] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, by weight, 0.05 to 3 parts of a moisturizing lubricant; the moisturizing lubricant is sodium hyaluronate and polyvinylpyrrolidone. As one embodiment of this invention, the moisturizing lubricant comprises, by weight, 0.05 to 1 part of sodium hyaluronate, more specifically 0.05 to 0.5 parts, specifically 0.05 parts, 0.1 parts, or 0.5 parts.

[0021] In one embodiment of the present invention, the components of the moisturizing lubricant include 0.1 to 2 parts of polyvinylpyrrolidone by mass, and may further be 0.1 to 0.5 parts, specifically 0.1, 0.2 or 0.5 parts.

[0022] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, based on a total mass fraction of 1000 parts, 0.1 to 5 parts of stabilizer. In one embodiment of this invention, the stabilizer may further be 0.3 to 4 parts, specifically 0.5 parts, 1 part, or 3 parts.

[0023] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, based on a total mass of 1000 parts, 0.001 to 0.003 parts of preservative. In one embodiment of this invention, the preservative may further be 0.001 to 0.002 parts, specifically 0.0012 parts; the preservative is one or more of polyhexamethylene biguanide, polyquaternium salt, and sodium chlorite.

[0024] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, in a total mass fraction of 1000 parts, 6-9 parts of a buffer. In one embodiment of this invention, the buffer may further comprise 7-8 parts, specifically 7.5 parts; the buffer is one or more of sodium dihydrogen phosphate-disodium hydrogen phosphate, tromethamine-hydrochloric acid, and boric acid-borax.

[0025] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, in a total mass fraction of 1000 parts, 5-8 parts of an osmotic pressure regulator. In one embodiment of this invention, the osmotic pressure regulator may further be 5-6 parts, specifically 5.5 parts; the osmotic pressure regulator is sodium chloride and / or potassium chloride.

[0026] The antioxidant, moisturizing, and water-locking contact lens solution of this invention comprises, based on a total mass fraction of 1000 parts, a chelating agent of 0.1 to 1 part. In one embodiment of this invention, the chelating agent may further be 0.3 to 0.7 parts, specifically 0.5 parts; the chelating agent is one or both of disodium ethylenediaminetetraacetate and sodium citrate.

[0027] The antioxidant, moisturizing, and water-locking contact lens care solution of this invention comprises water in a total mass fraction of 1000 parts. In one embodiment of this invention, the water is purified water; the total mass fraction of the contact lens compound care solution is brought to 1000 parts by adding purified water.

[0028] This invention adjusts the mass fraction of osmotic pressure regulator and buffer to achieve an osmotic pressure of 260~340 mOsm / Kg and a pH value of 6.5~7.8 for the antioxidant, moisturizing and water-locking contact lens solution. This ensures that the antioxidant, moisturizing and water-locking contact lens solution has excellent biocompatibility and safety for ocular tissues, reduces the irritation of the components of the contact lens compound solution to sensitive eyes, and improves the wearing comfort of contact lenses.

[0029] This invention provides a method for preparing the antioxidant, moisturizing, and water-locking contact lens care solution described in the above technical solution, comprising the following steps: The components of the antioxidant moisturizing and water-locking contact lens solution are mixed to obtain the antioxidant moisturizing and water-locking contact lens solution.

[0030] As one embodiment of the present invention, the preferred method for mixing the components of the contact lens compound maintenance solution includes: mixing a moisturizing lubricant, a buffer, an osmotic pressure regulator, a chelating agent, a stabilizer, and 800 parts by weight of pure water, stirring for a first time until completely dissolved, then adding a preservative and stirring for a second time until completely dissolved, and finally adding the remaining pure water to a total weight of 1000 parts. The preparation of the contact lens compound maintenance solution is carried out at room temperature. The present invention does not specifically limit the order of adding the components of the contact lens compound maintenance solution. The first stirring speed is 300-500 rpm, specifically 400 rpm, and the time is 20-40 minutes, specifically 30 minutes. The second stirring speed is 300-500 rpm, specifically 400 rpm, and the time is 20-40 minutes, specifically 30 minutes.

[0031] In one embodiment of the present invention, after adding the remaining pure water to a total weight of 1000 parts to obtain the prepared solution, the method further includes: filtering and sterilizing the prepared solution to obtain a compound contact lens care solution; the filtration and sterilization includes pre-filtration with a polypropylene filter cartridge and then sterilization filtration with a polyethersulfone sterilization-grade filter cartridge to meet the sterility requirements of the care solution.

[0032] To further illustrate the present invention, the technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments thereof. Obviously, the described embodiments are merely some embodiments of the present invention, and not all embodiments. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0033] Unless otherwise specified, all materials and reagents used in the following examples are commercially available. Experimental methods not specifically described in the examples are generally performed under standard conditions or as recommended by the manufacturer. In the examples of this invention, sodium hyaluronate (HA) and ergothioneine are manufactured by Bloomage Biotechnology Co., Ltd., and polyvinylpyrrolidone is manufactured by BASF Ltd. All raw materials in the following examples are calculated in parts by weight.

[0034] Example 1 At room temperature, add 800 parts of pure water to a beaker. Weigh out 5.5 parts of sodium chloride, 6.4 parts of boric acid, 1.1 parts of borax, 0.1 parts of polyvinylpyrrolidone, 0.5 parts of sodium hyaluronate, 0.5 parts of ergothioneine, and 0.5 parts of disodium EDTA and add them to the beaker. Stir at 400 rpm for 30 minutes until the components are completely dissolved. Add 0.0012 parts of polyhexamethylene biguanide to the beaker and continue stirring for 30 minutes. Add pure water to bring the total weight to 1000 parts. Filter the resulting solution to remove bacteria, and you will get an antioxidant, moisturizing, and water-locking contact lens care solution.

[0035] Example 2 It is basically the same as Example 1, except that 0.1 parts of sodium hyaluronate and 1 part of ergothioneine are added.

[0036] Example 3 It is basically the same as Example 1, except that 0.05 parts of sodium hyaluronate and 3 parts of ergothioneine are added.

[0037] Example 4 It is basically the same as Example 1, except that 0.2 parts of polyvinylpyrrolidone are added.

[0038] Example 5 The method is basically the same as in Example 1, except that 0.2 parts of polyvinylpyrrolidone, 0.1 parts of sodium hyaluronate, and 1 part of ergothioneine are added.

[0039] Example 6 The experiment was basically the same as in Example 1, except that 0.2 parts of polyvinylpyrrolidone, 0.05 parts of sodium hyaluronate, and 3 parts of ergothioneine were added.

[0040] Example 7 It is basically the same as Example 1, except that 0.5 parts of polyvinylpyrrolidone are added.

[0041] Example 8 It is basically the same as Example 1, except that 0.5 parts of polyvinylpyrrolidone, 0.1 parts of sodium hyaluronate, and 1 part of ergothioneine are added.

[0042] Example 9 The experiment was basically the same as in Example 1, except that 0.5 parts of polyvinylpyrrolidone, 0.05 parts of sodium hyaluronate, and 3 parts of ergothioneine were added.

[0043] Comparative Example 1 The method is basically the same as in Example 1, except that 0.2 parts of polyvinylpyrrolidone and 0.1 parts of sodium hyaluronate are added, and ergothioneine is not added.

[0044] Comparative Example 2 It is basically the same as Example 1, except that 0.2 parts of polyvinylpyrrolidone and 1 part of ergothioneine are added, and sodium hyaluronate is not added.

[0045] Comparative Example 3 It is basically the same as Example 1, except that 0.1 parts of sodium hyaluronate and 1 part of ergothionein are added, and polyvinylpyrrolidone is not added.

[0046] Test Example 1 The antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 1-9 were subjected to osmotic pressure tests, pH tests, and cytotoxicity experiments. The cytotoxicity experiments included negative and positive controls, which served as standard control samples for the cytotoxicity test. The negative control was a phosphate buffer solution without calcium and magnesium ions, with a volume ratio of 0.15:1 to the culture medium. The positive control was dimethyl sulfoxide, with a volume ratio of 0.15:1 to the culture medium. In the experimental groups, the volume ratio of the antioxidant, moisturizing, and water-locking contact lens solutions from Examples 1-9 to the culture medium was 0.15:1. Osmotic pressure tests were performed according to the 2025 edition of the Pharmacopoeia of the People's Republic of China, Part IV, General Chapter 0632, "Determination of Osmotic Molar Concentration," using a Shanghai Medical University FM-8P freezing point osmoremeter. The test results are detailed in Table 1. pH tests were performed according to the 2025 edition of the Pharmacopoeia of the People's Republic of China, Part IV, General Chapter 0631, "Determination of pH," using a Mettler Toledo pH meter. The test results are detailed in Table 1. The tests were conducted according to GB / T... The cytotoxicity test was performed in accordance with the requirements of 16886.5 "Biological evaluation of medical devices - Part 5: In vitro cytotoxicity test". The test results are detailed in Table 1.

[0047] Table 1. Physicochemical parameters and cytotoxicity test results of the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 1-9.

[0048] The data in Table 1 show that the osmotic pressure of the antioxidant, moisturizing, and water-locking contact lens solution prepared in this invention is between 260 and 340 mOsm / kg, and the pH is between 6.5 and 7.8, meeting the requirements of standard YY0719.2-2009. The cell proliferation rate of the antioxidant, moisturizing, and water-locking contact lens solution prepared in this invention is greater than 80%, proving that it does not have potential cytotoxicity.

[0049] The antioxidant moisturizing and water-locking contact lens solutions prepared in Examples 4-6, the negative control group, the positive control group, and the commercially available solutions were subjected to cytotoxicity experiments using the methods described above. The test results are detailed in Table 2.

[0050] Among them, the commercially available maintenance solution A is a hyaluronic acid contact lens lubricant purchased from Weikang Company, and its ingredients are: HA (1.6mg / ml), polyaminopropyl biguanide, sodium chloride, boric acid and borax; The commercially available contact lens solution B is ANNASUI HA hyaluronic acid contact lens lubricant purchased from Zhongrun Company. Its ingredients are: sodium chloride, potassium chloride, boric acid, borax, disodium edetate, poloxamer, HA, PVP and PHMB. Commercially available contact lens solution C is Alcon contact lens lubricant (Ciba Vision / Opti-Free), purchased from Alcon Corporation. Its ingredients are: sodium chloride, potassium chloride, sodium borate, HPMC (0.3%), dextran 70 (0.1%), and PQ-1 (0.001%). The commercially available contact lens solution D is Bausch & Lomb ReNu New Concept Long-Lasting Contact Lens Lubricant, purchased from Bausch & Lomb. Its ingredients are: sodium chloride, potassium chloride, boric acid, sodium borate, disodium edetate (0.1%), PVP, and sorbic acid (0.1%).

[0051] Table 2. Cytotoxicity test results of the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 4-6 and commercially available solutions.

[0052] The data in Table 2 show that the antioxidant, moisturizing and water-locking contact lens solution prepared in this invention has a higher cell proliferation rate than the four commercially available solutions mentioned above, indicating that the antioxidant, moisturizing and water-locking contact lens solution prepared in this invention has lower cytotoxicity and lower irritation.

[0053] Test Example 2 The antioxidant moisturizing and water-locking contact lens care solutions prepared in Examples 1-9 were tested for their preservative effectiveness according to the requirements of YY / T 0719.4-2009 "Ophthalmic Optical Contact Lens Care Products Part 4: Antimicrobial Preservative Effectiveness Test and Determination of Disposal Date Guidelines", and the results are shown in Table 3.

[0054] Table 3. Experimental results on the preservative efficacy of the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 1-9.

[0055] The data in Table 3 show that the antioxidant moisturizing and water-locking contact lens solutions prepared in Examples 1-9 did not show the growth of common harmful microorganisms after 14 and 28 days of use after opening, and all met the requirements of YY0719.4-2009 standard. The preservative effect of Examples 1, 4 and 7 was not as good as that of other examples, indicating that the amount of sodium hyaluronate added affected the preservative effect of the product.

[0056] Test Example 3 The antioxidant moisturizing and water-locking contact lens solutions prepared in Examples 2, 3, 5, 6, 8, and 9, as well as the antioxidant moisturizing and water-locking contact lens solutions prepared in Comparative Examples 1-3, and pure water were subjected to DPPH free radical scavenging rate tests. The results are shown in Table 4. The lower the scavenging rate, the more stable the product.

[0057] Table 4. Comparison of DPPH free radical scavenging rates between the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 2, 3, 5, 6, 8, 9 and Comparative Examples 1-3 and pure water.

[0058] The data in Table 4 show that the moisturizing effect of all examples and comparative examples is better than that of pure water. The order of free radical scavenging effect of each example and comparative example from best to worst is as follows: Example 5 > Example 2 > Example 8 > Example 6 ≈ Example 9 > Example 3 > Comparative Example 3 > Comparative Example 2 > Comparative Example 1 > Pure water.

[0059] The antioxidant moisturizing and water-locking contact lens solutions prepared in Examples 2, 5 and 8 were compared with four commercially available solutions and pure water to test the DPPH free radical scavenging rate. The results are shown in Table 5.

[0060] Table 5. Comparison of DPPH free radical scavenging rates between the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 2, 5, and 8, and four commercially available solutions and pure water.

[0061] The data in Table 5 show that all the examples and comparative examples have better moisturizing effects than pure water. The free radical scavenging effects of each example and comparative example are arranged from best to worst as follows: Example 5 > Example 2 > Example 8 > Commercially available skin care liquid D > Commercially available skin care liquid C > Commercially available skin care liquid A > Commercially available skin care liquid B > Pure water.

[0062] Test Example 4 The antioxidant moisturizing and water-locking contact lens solutions prepared in Examples 2, 3, 5, 6, 8, and 9, as well as the antioxidant moisturizing and water-locking contact lens solutions prepared in Comparative Examples 1-3, were subjected to contact angle tests. The results are shown in Table 6. The lower the contact angle, the better the moisturizing effect.

[0063] Table 6. Comparison of contact angles between the antioxidant, moisturizing, and water-locking contact lens solutions prepared in Examples 2, 3, 5, 6, 8, 9 and Comparative Examples 1-3 and standard saline solution.

[0064] The data in Table 6 show that all the examples and comparative examples have better moisturizing effects than the standard saline solution. The moisturizing effects of each example and comparative example are arranged from best to worst as follows: Example 5 > Example 8 > Example 2 > Example 3 > Example 9 > Example 6 > Example 1 > Comparative Example 1 > Comparative Example 3 > Comparative Example 2 > Standard saline solution.

[0065] The contact angle of the antioxidant moisturizing and water-locking contact lens solution prepared in Example 5 was tested against four commercially available solutions, and the results are shown in Table 7.

[0066] Table 7. Comparison of contact angle data between the antioxidant, moisturizing, and water-locking contact lens solution prepared in Example 5 and four commercially available solutions.

[0067] The data in Table 7 show that the antioxidant moisturizing and water-locking contact lens solution prepared in Example 5 has a lower contact angle than the above four commercially available solutions, indicating that the antioxidant moisturizing and water-locking contact lens solution prepared in this invention has a better moisturizing effect.

[0068] This document uses specific examples to illustrate the principles and implementation methods of the present invention. The descriptions of the above embodiments are only for the purpose of helping to understand the method and core ideas of the present invention. Furthermore, those skilled in the art will recognize that, based on the ideas of the present invention, there will be changes in the specific implementation methods and application scope. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. An antioxidant, moisturizing, and water-locking contact lens solution, comprising the following components in a total mass fraction of 1000 parts: 0.05-3 parts of moisturizing lubricant, 0.001-0.003 parts of preservative, 6-9 parts of buffer, 5-8 parts of osmotic pressure regulator, 0.1-1 part of chelating agent, 0.1-5 parts of stabilizer, with the balance being water; wherein the moisturizing lubricant is sodium hyaluronate and polyvinylpyrrolidone; and the stabilizer is ergothioneine.

2. The antioxidant, moisturizing, and water-locking contact lens solution according to claim 1, characterized in that, The moisturizing lubricant, by weight, comprises: 0.05-1 parts sodium hyaluronate and 0.1-2 parts polyvinylpyrrolidone; the stabilizer comprises 0.3-4 parts.

3. The antioxidant, moisturizing, and water-locking contact lens care solution according to claim 2, characterized in that, The moisturizing lubricant, by weight, comprises: 0.05-0.5 parts sodium hyaluronate and 0.1-0.5 parts polyvinylpyrrolidone; The stabilizer is present in a quantity of 0.5 to 3 parts.

4. The antioxidant, moisturizing, and water-locking contact lens solution according to claim 1, characterized in that, The preservative is one or more of polyhexamethylene biguanide, polyquaternium salt, and sodium chlorite.

5. The antioxidant, moisturizing, and water-locking contact lens care solution according to claim 1, characterized in that, The buffer is one or more of sodium dihydrogen phosphate-disodium hydrogen phosphate, tromethamine-hydrochloric acid, and boric acid-borax.

6. The antioxidant, moisturizing, and water-locking contact lens solution according to claim 1, characterized in that, The osmotic pressure regulator is sodium chloride and / or potassium chloride.

7. The antioxidant, moisturizing, and water-locking contact lens solution according to claim 1, characterized in that, The chelating agent is one or both of disodium ethylenediaminetetraacetate and sodium citrate.

8. The antioxidant, moisturizing, and water-locking contact lens solution according to any one of claims 1 to 7, characterized in that, The osmotic pressure of the antioxidant, moisturizing, and water-locking contact lens care solution is 260~340 mOsm / Kg.

9. The antioxidant, moisturizing, and water-locking contact lens solution according to any one of claims 1 to 7, characterized in that, The pH value of the antioxidant, moisturizing, and water-locking contact lens care solution is 6.5~7.

8.

10. A method for preparing the antioxidant, moisturizing, and water-locking contact lens solution according to any one of claims 1 to 9, comprising the following steps: The components of the antioxidant moisturizing and water-locking contact lens solution are mixed to obtain the antioxidant moisturizing and water-locking contact lens solution.

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