A transmembrane resistance detection device

Abstract

The application relates to the technical field of transmembrane resistance detection in biomedical engineering, and more particularly to a transmembrane resistance detection device. The device comprises a base, a lifting platform mounted on the base, a supporting frame mounted on the base, a guide rail, a sliding block and electrodes. The guide rail is horizontally mounted on the supporting frame, and the guide rail and the supporting frame are slidably connected in the horizontal direction. The sliding block is provided with at least two sliding blocks, each of which is slidably connected with the guide rail, and the electrodes are detachably mounted on the sliding block. The distance between the two electrodes can be adjusted by sliding the sliding block. The guide rail and the supporting frame can slide in the horizontal direction, and the position of the guide rail can be changed by moving the guide rail as a whole, so that more specifications of culture containers or organ chips can be adapted. The depth of the electrodes inserted into the measured chip can be adjusted by the lifting platform, and the universality of the device and the repeatability of the detection data are improved.

Description

Technical Field

[0001] This application relates to the field of transmembrane resistance detection technology in biomedical engineering, and more specifically, to a transmembrane resistance detection device. Background Technology

[0002] Transepithelial / transendothelial electrical resistance (TEER) is a crucial quantitative indicator for assessing the integrity and permeability of in vitro barrier models (such as intestinal epithelium and the blood-brain barrier). TEER detection, based on minute electrical signals, enables rapid, real-time, non-invasive, and label-free monitoring of barrier function without interfering with subsequent culture and characterization, thus being considered the "gold standard" for barrier model construction and dynamic functional assessment in organ-on-a-chip systems. However, current TEER detection devices used in traditional culture systems such as Transwell (a laboratory technology device for cell biology research) or organ-on-a-chip systems face significant technical bottlenecks, making it difficult to match the development of advanced models like organ-on-a-chip. The diverse chip structures on the market, coupled with the fixed electrode structures and poor adaptability of traditional detection devices, often necessitate the design of individual detection devices for each chip, failing to guarantee the consistency and comparability of detection results across different systems. Summary of the Invention

[0003] The purpose of this invention is to overcome the shortcomings of existing transmembrane resistance detection devices that cannot be adapted to the detection of various types of culture containers or organ-on-a-chip, and to provide a membrane resistance detection device that is compatible with the detection of transmembrane resistance of culture containers or organ-on-a-chip of different specifications.

[0004] To solve the above-mentioned technical problems, the technical solution adopted by the present invention is as follows: A transmembrane resistance detection device is provided, including a base, a lifting platform mounted on the base, a support frame mounted on the base, a guide rail, a slider, and an electrode; the guide rail is horizontally mounted on the support frame and the guide rail and the support frame are slidably connected in the horizontal direction; at least two sliders are provided, each slider is slidably connected to the guide rail; and the electrode is detachably mounted on the slider.

[0005] This invention discloses a transmembrane resistance detection device. The chip to be tested is placed on a lifting platform. The number of sliders and electrodes is selected according to the actual testing needs. The distance between two electrodes can be adjusted by sliding the slider. The guide rail and support frame can slide in the horizontal direction. By moving the guide rail as a whole, the position of the guide rail can be changed, thereby adapting to more specifications of culture containers or organ-on-a-chip. The depth of electrode insertion into the chip to be tested can be adjusted by the lifting platform. This improves the versatility of the device and the repeatability of the test data.

[0006] In one embodiment, the guide rail includes an X-axis guide rail and a Y-axis guide rail, the X-axis guide rail being arranged along the X direction and the Y-axis guide rail being arranged along the Y direction; a first sliding groove is provided on the support frame along the X direction and a second sliding groove is provided along the Y direction; the X-axis guide rail is slidably connected to the second sliding groove and the Y-axis guide rail is slidably connected to the first sliding groove; the slider is slidably mounted on both the X-axis guide rail and the Y-axis guide rail. The X-axis guide rail can slide along the second sliding groove in the Y direction, and the slider on the X-axis guide rail can slide along the X direction on the X-axis guide rail, so that the slider on the X-axis guide rail can change its position in the X and Y directions; similarly, the slider on the Y-axis guide rail can also change its position in the X and Y directions; in actual testing, the slider and electrode at the corresponding positions can be selected as needed to adapt to different models and specifications of the chip under test, and the number of sliders and electrodes can also be selected as needed to adapt to different testing methods, such as the ohm method or impedance spectroscopy.

[0007] In one embodiment, the X-axis guide rail is provided in two sets, namely a first guide rail and a second guide rail, which are arranged parallel to and spaced apart from each other; the slider includes a first slider and a second slider, the first slider is slidably connected to both the first guide rail and the Y-axis guide rail; the second slider is slidably connected to both the second guide rail and the Y-axis guide rail.

[0008] In one embodiment, the Y-axis guide rail has two sets, namely a third guide rail and a fourth guide rail, which are parallel and spaced apart. The slider also includes a third slider and a fourth slider. The first slider is slidably connected to both the first and third guide rails, the second slider is slidably connected to both the second and third guide rails, the third slider is slidably connected to both the first and fourth guide rails, and the fourth slider is slidably connected to both the third and fourth guide rails. The first, second, third, and fourth guide rails form a crisscrossing structure, with a slider at each of the four intersection points. Each slider is slidably connected to both the X-axis and Y-axis guide rails. This configuration allows the sliders at the four intersection points to move in tandem. For symmetrically arranged chips, this enables rapid electrode positioning, facilitating operation and improving detection efficiency.

[0009] In one embodiment, the slider has a first through hole along the X direction and a second through hole along the Y direction; the X-axis guide rail passes through the first through hole and the Y-axis guide rail passes through the second through hole.

[0010] In one embodiment, the slider is provided with a first locking member for restricting the slider's movement. The first locking member has two sets: one set restricts the slider's movement along the X-axis guide rail, and the other set restricts the slider's movement along the Y-axis guide rail. During testing, the slider's position is locked by the first locking member, preventing the slider from sliding during the test and improving the stability of the test.

[0011] In one embodiment, a second locking member is provided at the end of the X-axis guide rail to restrict the X-axis guide rail from sliding along the second slide groove; a third locking member is provided at the end of the Y-axis guide rail to restrict the Y-axis guide rail from sliding along the first slide groove. The position of the X-axis guide rail is locked by the second locking member, and the position of the Y-axis guide rail is locked by the third locking member to prevent the guide rails from sliding during the test.

[0012] In one embodiment, a third through hole is provided on the slider along the Z-axis, and the electrode is inserted into the third through hole. The electrode is inserted into the third through hole, and a limiting boss can be provided at one end of the electrode. This facilitates electrode installation and quick positioning, and also prevents the electrode from falling out. The electrode and slider are inserted together, making electrode replacement convenient.

[0013] In one embodiment, the lifting platform includes a loading platform, a lifting mechanism, and a drive mechanism. The lifting mechanism is mounted on the base, the loading platform is connected to the lifting mechanism, and the output end of the drive mechanism is connected to the lifting mechanism.

[0014] In one embodiment, the lifting mechanism includes a scissor lift mechanism, a lead screw lift mechanism, or a cylinder lift mechanism.

[0015] In one embodiment, the support frame includes vertically arranged support columns and horizontally arranged support crossbars. The support columns are disposed on the base, and there are at least two sets of support crossbars. The first set of support crossbars is arranged along the X direction, and the second set of support crossbars is arranged along the Y direction. The first sliding groove is disposed on the first set of support crossbars, and the second sliding groove is disposed on the second set of support crossbars.

[0016] In one embodiment, a limiting groove is provided along the direction of the first slide groove, and a limiting groove is also provided along the direction of the second slide groove; a limiting protrusion is provided on the guide rail corresponding to the position of the limiting groove, and the limiting protrusion is slidably disposed in the limiting groove.

[0017] Compared with the prior art, the beneficial effects of the present invention are: This invention provides a transmembrane resistance testing device. A lifting platform allows adjustment of the electrode insertion depth into the chip under test, while a slider and guide rail allow adjustment of the electrode position and spacing, thus adapting to different specifications and models of chips under test. The number of electrodes can also be selected according to requirements, adapting to different testing methods. This invention's device is highly versatile and improves the stability and repeatability of test data. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of the transmembrane resistance detection device in one embodiment; Figure 2 This is a schematic diagram of the installation of the guide rail, slider, and support frame in one embodiment; Figure 3 This is a schematic diagram of the lifting platform structure in one embodiment; Figure 4 This is a schematic diagram of the support frame structure in another embodiment; Figure 5 This is a schematic diagram of the guide rail structure in one embodiment; Figure 6 This is a schematic diagram of the slider structure in one embodiment; Figure 7 This is a schematic diagram of the four-point impedance spectroscopy method for detecting transmembrane resistance on an organ-on-a-chip. Figure 8 This is a schematic diagram of the device of the present invention adapted to organ-on-a-chip of different sizes.

[0019] Figure 9 This is an illustration of the electrode adjustment range in one embodiment; Figure 10 In one embodiment, the device is used for detection on organ-on-a-chip A; Figure 11 In one embodiment, the device is used for detection on organ-on-a-chip B; Figure 12 In another embodiment, the apparatus is used for detection in a 24-well plate Transwell. Figure 13 This is a physical image of organ-on-a-chip A and organ-on-a-chip B in one embodiment.

[0020] In the attached diagram: 100, base; 200, lifting platform; 210, carrying platform; 220, lifting mechanism; 230, drive mechanism; 300, support frame; 310, second slide rail; 320, first slide rail; 330, support pole; 340, support crossbar; 350, limiting groove; 400, guide rail; 410, X-axis guide rail; 420, Y-axis guide rail; 430, limiting protrusion; 500, slider; 510, first through hole; 520, second through hole; 530, third through hole; 600, electrode. Detailed Implementation

[0021] The present invention will be further described below with reference to specific embodiments. The accompanying drawings are for illustrative purposes only, representing schematic diagrams rather than actual physical objects, and should not be construed as limiting the invention. To better illustrate the embodiments of the invention, some components in the drawings may be omitted, enlarged, or reduced, and do not represent the actual dimensions of the product. It is understandable to those skilled in the art that some well-known structures and their descriptions may be omitted in the drawings.

[0022] In the accompanying drawings of the embodiments of the present invention, the same or similar reference numerals correspond to the same or similar components. In the description of the present invention, it should be understood that if terms such as "upper," "lower," "left," "right," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the drawings, they are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, the terms used to describe positional relationships in the drawings are only for illustrative purposes and should not be construed as limiting the present invention. For those skilled in the art, the specific meaning of the above terms can be understood according to the specific circumstances.

[0023] Example 1 This embodiment is a first embodiment of a transmembrane resistance detection device, such as... Figures 1 to 2 As shown, it includes a base 100, a lifting platform 200 mounted on the base 100, a support frame 300 mounted on the base 100, a guide rail 400, a slider 500, and an electrode 600; the guide rail 400 is horizontally mounted on the support frame 300, and the guide rail 400 and the support frame 300 are slidably connected in the horizontal direction; at least two sliders 500 are provided, and each slider 500 is slidably connected to the guide rail 400; the electrode 600 is detachably mounted on the slider 500.

[0024] Specifically, in this embodiment, the guide rail 400 includes an X-axis guide rail 410 and a Y-axis guide rail 420. The X-axis guide rail 410 is arranged along the X direction, and the Y-axis guide rail 420 is arranged along the Y direction. A first sliding groove 320 is provided on the support frame 300 along the X direction, and a second sliding groove 310 is provided along the Y direction. The X-axis guide rail 410 is slidably connected to the second sliding groove 310, and the Y-axis guide rail 420 is slidably connected to the first sliding groove 320. A slider 500 is slidably mounted on both the X-axis guide rail 410 and the Y-axis guide rail 420. The X-axis guide rail 410 can slide along the second slide groove 310 in the Y direction. The slide rail on the X-axis guide rail 410 can slide along the X direction on the X-axis guide rail 410, so the slider 500 on the X-axis guide rail 410 can change its position in the X and Y directions. Similarly, the slider 500 on the Y-axis guide rail 420 can also change its position in the X and Y directions. In actual testing, the slider 500 and electrode 600 at the corresponding positions can be selected as needed to adapt to different models and specifications of the chip under test. The number of sliders 500 and electrodes 600 can also be selected as needed to adapt to different testing methods, such as using the ohm method or impedance spectroscopy to measure the TEER value of the barrier model.

[0025] For example, a four-electrode system can be used to measure the TEER value using four-point impedance spectroscopy. By using independent excitation electrode pairs and sensing electrode pairs, the interference of electrode polarization and contact impedance on the measurement signal is eliminated, resulting in more accurate and stable results than commonly used two-electrode detection devices based on the ohm method. Specifically, a pair of current excitation electrodes can be connected to the working electrode and counter electrode of a signal source (such as an electrochemical workstation), applying a small alternating current with a constant amplitude (e.g., 10 μA) and a frequency sweeping within a certain range (e.g., 10 Hz to 100 kHz); another pair of independent voltage sensing electrodes can be connected to the sensing electrode and reference electrode, simultaneously measuring the potential difference generated on both sides of the barrier, thereby detecting the constant current AC impedance spectrum, such as... Figure 7 As shown, by combining existing automated algorithms to complete spectrum fitting and calculation, the TEER value and capacitance value are directly output, improving detection accuracy and timeliness.

[0026] This embodiment of a transmembrane resistance detection device places the chip to be tested on a lifting platform 200. The number of sliders 500 and electrodes 600 is selected according to the actual detection needs. The spacing between two electrodes 600 can be adjusted by sliding slider 500. The guide rail 400 and the support frame 300 can slide in the horizontal direction. By moving the guide rail 400 as a whole, the position of the guide rail 400 can be changed, thereby adapting to more specifications of culture containers or organ-on-a-chip. The depth of the electrode 600 inserted into the chip to be tested can be adjusted by lifting platform 200. This improves the versatility of the device and the repeatability of the detection data.

[0027] Example 2 This embodiment is a second embodiment of a transmembrane resistance detection device. This embodiment is similar to the first embodiment, except that, as shown in the following... Figure 1 and Figure 2 As shown, in this embodiment, the X-axis guide rail 410 has two sets, namely a first guide rail and a second guide rail, which are arranged parallel and spaced apart. The slider 500 includes a first slider and a second slider. The first slider is slidably connected to both the first guide rail and the Y-axis guide rail 420. The second slider is slidably connected to both the second guide rail and the Y-axis guide rail 420. The Y-axis guide rail 420 has two sets, namely a third guide rail and a fourth guide rail, which are arranged parallel and spaced apart. The slider 500 also includes a third slider and a fourth slider. The first slider is slidably connected to both the first and third guide rails, the second slider is slidably connected to both the second and third guide rails, the third slider is slidably connected to both the first and fourth guide rails, and the fourth slider is slidably connected to both the third and fourth guide rails. The first, second, third, and fourth guide rails form a crisscross structure. A slider 500 is set at each of the four intersection points. The slider 500 is simultaneously slidably connected to the X-axis guide rail 410 and the Y-axis guide rail 420. In this configuration, the sliders 500 at the four intersection points are linked together. For symmetrically arranged chips, the position of the electrode 600 can be quickly positioned, making operation convenient and improving detection efficiency.

[0028] This embodiment provides a transmembrane resistance detection device in which four electrodes 600 at intersecting positions are linked for adjustment. When adjusting their positions, sliding one slider 500 will cause the other two sliders 500 to move synchronously. The four electrodes 600 are always symmetrically arranged, whereas most organ-on-a-chip, Transwell, and well plate culture containers on the market are mostly symmetrically arranged. Figure 8 As shown, the detection device in this embodiment is particularly suitable for measuring TEER values ​​using a four-electrode 600 system and a four-point impedance spectroscopy method.

[0029] It should be noted that the four-electrode system detection is only a preferred solution in this embodiment. In actual detection, in order to adapt to the structural size of the culture container, the installation position and number of sliders 500 can be selected according to the requirements. The number of X-axis guide rails 410 and Y-axis guide rails 420 is not limited to two rows and two columns as shown in the attached figure, and can also be more or less.

[0030] In this embodiment, as Figure 9 As shown, the adjustable spacing of electrode 600 is set between 6mm and 105mm, with a maximum spacing of 105mm and a minimum spacing of 6mm between the two electrodes 600, making it adaptable to the sizes of most culture containers; for example Figures 10-13As shown, these were used on two different organ-on-a-chip structures and a 24-well Transwell plate, respectively. Organ-on-a-chip A is a three-channel structure chip with a liquid limiting strip, as shown... Figure 10 and Figure 13 As shown, organ-on-a-chip B is a sandwich structure chip containing a porous membrane, such as... Figure 11 and Figure 13 As shown, the device's electrode position adjustment function allows the needle electrodes to be aligned with the openings of different containers, and the platform height adjustment function allows the chip height to be raised as needed until the electrode tips are immersed in the culture medium within the opening to form an electrical connection. Clearly, the specific organ-on-a-chip and Transwell used here are merely examples, and the device is not limited to application on these culture containers.

[0031] In actual AC impedance spectroscopy measurements, electrode 600 needs to be connected to detection equipment such as an electrochemical workstation and an impedance spectrometer. If the above-mentioned four-point impedance spectroscopy method is used, one pair of electrodes 600 is connected to the working electrode 600 and the counter electrode 600 of the electrochemical workstation, and the other pair of electrodes 600 is connected to the sensing electrode 600 and the reference electrode 600.

[0032] Example 3 This embodiment is a third embodiment of a transmembrane resistance detection device. This embodiment is similar to the first embodiment, except that, as shown in the following... Figure 1 , Figure 2 ,as well as Figure 4 As shown, the support frame 300 includes vertically arranged support rods 330 and horizontally arranged support crossbars 340. There are four support rods 330 and two sets of support crossbars 340, with two crossbars in each set. The two crossbars 340 in the first set are spaced apart along the X-direction, and the two crossbars 340 in the second set are spaced apart along the Y-direction, forming a square frame structure. A first sliding groove 320 is provided on the first set of support crossbars 340, and a second sliding groove 310 is provided on the second set of support crossbars 340. Both ends of the X-axis are slidably connected to the two second sliding grooves 310, and both ends of the Y-axis are slidably connected to the two first sliding grooves 320. To facilitate simultaneous sliding connection of the slider 500 with both the X-axis and Y-axis, the height of the first sliding groove 320 can be slightly higher or lower than the height of the second sliding groove 310. For ease of installation, the X-axis guide rail 410 and the second sliding groove 310, and the Y-axis guide rail 420 and the first sliding groove 320 are detachably connected.

[0033] In this embodiment, as Figure 4 and Figure 5As shown, a limiting groove 350 is provided on the support crossbar 340 along the direction of the first slide groove 320, and a limiting groove 350 is also provided on the support crossbar 340 along the direction of the second slide groove 310; limiting protrusions 430 corresponding to the positions of the limiting grooves 350 are provided on both the X-axis guide rail 410 and the Y-axis guide rail 420. The limiting protrusions 430 engage with the limiting grooves 350 to achieve positioning and limiting.

[0034] In this embodiment, as Figure 1 , Figure 2 as well as Figure 6 As shown, the slider 500 has a first through hole 510 along the X direction and a second through hole 520 along the Y direction. The X-axis guide rail 410 passes through the first through hole 510, and the Y-axis guide rail 420 passes through the second through hole 520. The slider 500 is directly mounted on the X-axis guide rail 410 and / or the Y-axis guide rail 420, resulting in a simple structure, convenient installation, and easy adjustment. The slider 500 is equipped with a first locking element to limit its sliding. Two sets of the first locking element are provided: one set restricts the slider 500 from sliding along the X-axis guide rail 410, and the other set restricts it from sliding along the Y-axis guide rail 420. During testing, the first locking element locks the position of the slider 500, preventing it from sliding during the test and improving test stability. The first locking element can preferably be a fastening screw, with a screw hole opened at a corresponding position on the slider 500. For example, to restrict the slider 500 from sliding along the X-axis guide rail 410, a screw hole can be opened on the side of the slider 500, and the fastening screw can be installed in the screw hole. When the fastening screw is tightened, the end of the fastening screw abuts against the X-axis guide rail 410, thus restricting the slider 500 from sliding relative to the X-axis guide rail 410.

[0035] In this embodiment, a second locking member is provided at the end of the X-axis guide rail 410 to restrict the sliding of the X-axis guide rail 410 along the second slide groove 310; a third locking member is provided at the end of the Y-axis guide rail 420 to restrict the sliding of the Y-axis guide rail 420 along the first slide groove 320. The position of the X-axis guide rail 410 is locked by the second locking member, and the position of the Y-axis guide rail 420 is locked by the third locking member, preventing the guide rail 400 from sliding during the test. As shown in the figure, both the first slide groove 320 and the second slide groove 310 are through grooves. The second and third locking members can also preferably be fastening screws. Screw holes are opened at both ends of the X-axis guide rail 410 and the Y-axis guide rail 420. The fastening screw passes through the through groove from the outside of the cross column and is inserted into the screw hole. Tightening the screw can lock the X-axis guide rail 410 or the Y-axis guide rail 420.

[0036] The fastening screws are not shown in the attached figures, but those skilled in the art can clearly understand the installation location and implementation method of the fastening screws based on the above description.

[0037] In this embodiment, a third through hole 530 is provided on the slider 500 along the Z-axis direction, and the electrode 600 is inserted into the third through hole 530. The electrode 600 is inserted into the third through hole 530, and a limiting boss can be provided at one top end of the electrode 600. This facilitates the installation of the electrode 600 and enables quick positioning; it also prevents the electrode 600 from falling out. The electrode 600 and slider 500 are inserted together, making it easy to replace the electrode 600.

[0038] This embodiment provides a transmembrane resistance detection device, which, by setting a locking component, can lock the positions of the slider 500 and the guide rail 400 after adjustment, thereby improving the stability during the testing process.

[0039] Example 4 This embodiment is a fourth embodiment of a transmembrane resistance detection device. This embodiment is similar to embodiment one, except that, as shown in the following... Figure 1 and Figure 3 As shown, the lifting platform 200 includes a loading platform 210, a lifting mechanism 220, and a drive mechanism 230. The lifting mechanism 220 is mounted on the base 100, the loading platform 210 is connected to the lifting mechanism 220, and the output end of the drive mechanism 230 is connected to the lifting mechanism 220.

[0040] In this embodiment, the lifting mechanism 220 adopts a scissor lift mechanism 2. The scissor lift mechanism used in this embodiment is similar to existing scissor lift mechanisms, utilizing a cross-hinged linkage (resembling scissors) to achieve a vertical lifting mechanical structure. Multiple sets of equal-length rods are hinged at the center to form an "X" shape. These X-shaped units are connected end-to-end, and the overall height of the mechanism is changed by altering the cross angle, thus achieving smooth lifting of the work platform. The drive mechanism 230 can be hydraulically driven or screw-driven. In this embodiment, as shown in the figure, a manually adjustable screw drive mechanism 230 is used. By rotating the handle, the cross angle of the scissor lift mechanism is changed, thereby driving the lifting of the loading platform 210.

[0041] It should be noted that the lifting mechanism 220 is not limited to a scissor lift mechanism. For those skilled in the art, any suitable lifting mechanism 220 can be selected according to actual needs, such as a lead screw lifting mechanism 22, an electric cylinder lifting mechanism, or a hydraulic cylinder lifting mechanism.

[0042] In the specific implementation of the above embodiments, the technical features can be combined in any non-contradictory way. For the sake of brevity, not all possible combinations of the above technical features are described. However, as long as the combination of these technical features is not contradictory, it should be considered to be within the scope of this specification.

[0043] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively describe all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A transmembrane resistance detection device, characterized in that, The device includes a base (100), a lifting platform (200) mounted on the base (100), a support frame (300) mounted on the base (100), a guide rail (400), a slider (500), and an electrode (600); the guide rail (400) is horizontally mounted on the support frame (300), and the guide rail (400) and the support frame (300) are slidably connected in the horizontal direction; at least two sliders (500) are provided, and each slider (500) is slidably connected to the guide rail (400); the electrode (600) is detachably mounted on the slider (500).

2. The transmembrane resistance detection device according to claim 1, characterized in that, The guide rail (400) includes an X-axis guide rail (410) and a Y-axis guide rail (420). The X-axis guide rail (410) is arranged along the X direction, and the Y-axis guide rail (420) is arranged along the Y direction. A first groove (320) is provided on the support frame (300) along the X direction, and a second groove (310) is provided along the Y direction. The X-axis guide rail (410) is slidably connected to the second groove (310), and the Y-axis guide rail (420) is slidably connected to the first groove (320). The slider (500) is slidably installed on both the X-axis guide rail (410) and the Y-axis guide rail (420).

3. The transmembrane resistance detection device according to claim 2, characterized in that, The X-axis guide rail (410) is provided in two sets, namely a first guide rail and a second guide rail, the first guide rail and the second guide rail are arranged parallel and spaced apart; the slider (500) includes a first slider and a second slider, the first slider is slidably connected to both the first guide rail and the Y-axis guide rail (420); the second slider is slidably connected to both the second guide rail and the Y-axis guide rail (420).

4. The transmembrane resistance detection device according to claim 2, characterized in that, The Y-axis guide rail (420) is provided in two sets, namely a third guide rail and a fourth guide rail, which are arranged parallel and spaced apart; the slider (500) also includes a third slider and a fourth slider; the first slider is slidably connected to both the first guide rail and the third guide rail, the second slider is slidably connected to both the second guide rail and the third guide rail; the third slider is slidably connected to both the first guide rail and the fourth guide rail, and the fourth slider is slidably connected to both the third guide rail and the fourth guide rail.

5. The transmembrane resistance detection device according to claim 3 or 4, characterized in that, The slider (500) has a first through hole (510) along the X direction and a second through hole (520) along the Y direction; the X-axis guide rail (410) passes through the first through hole (510) and the Y-axis guide rail (420) passes through the second through hole (520).

6. The transmembrane resistance detection device according to claim 5, characterized in that, The slider (500) is provided with a first locking member for restricting the sliding of the slider (500). The first locking member is provided in two sets, one set of which is used to restrict the slider (500) from sliding along the X-axis guide rail (410), and the other set of which is used to restrict the slider (500) from sliding along the Y-axis guide rail (420). The end of the X-axis guide rail (410) is provided with a second locking member for restricting the X-axis guide rail (410) from sliding along the second slide groove (310). The end of the Y-axis guide rail (420) is provided with a third locking member for restricting the Y-axis guide rail (420) from sliding along the first slide groove (320).

7. The transmembrane resistance detection device according to claim 5, characterized in that, A third through hole (530) is provided on the slider (500) along the Z-axis direction, and the electrode (600) is inserted into the third through hole (530).

8. The transmembrane resistance detection device according to any one of claims 1 to 4, characterized in that, The lifting platform (200) includes a loading platform (210), a lifting mechanism (220), and a drive mechanism (230). The lifting mechanism (220) is installed on the base (100). The loading platform (210) is connected to the lifting mechanism (220). The output end of the drive mechanism (230) is connected to the lifting mechanism (220).

9. The transmembrane resistance detection device according to any one of claims 2 to 4, characterized in that, The support frame (300) includes vertically arranged support rods (330) and horizontally arranged support crossbars (340). The support rods (330) are located on the base (100). There are at least two sets of support crossbars (340). The first set of support crossbars (340) is arranged along the X direction, and the second set of support crossbars (340) is arranged along the Y direction. The first sliding groove (320) is located on the first set of support crossbars (340), and the second sliding groove (310) is located on the second set of support crossbars (340).

10. The transmembrane resistance detection device according to claim 9, characterized in that, A limiting groove (350) is provided along the direction of the first slide groove (320), and a limiting groove (350) is also provided along the direction of the second slide groove (310); a limiting protrusion (430) corresponding to the position of the limiting groove (350) is provided on the guide rail (400), and the limiting protrusion (430) is slidably disposed in the limiting groove (350).

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