A camera assembly, a gene sequencer and a camera assembly method
Patent Information
- Application Number
- CN202611349892.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-09-01
- Publication Date
- 2026-10-27
Smart Images
Figure CN122984264A_ABST
Abstract
Description
Technical Field
[0001] This application relates to the field of gene sequencing technology, and in particular to a camera assembly and adjustment component, a gene sequencer, and a camera assembly and adjustment method. Background Technology
[0002] With the continuous improvement of time delay integration (TDI) cameras in terms of resolution, line frequency, and other indicators, their use in gene sequencers is becoming increasingly common. As part of the optical detection system of gene sequencers, the assembly precision requirements for time delay integration cameras are extremely high.
[0003] Time-delay integration cameras have a strip-shaped photosensitive area. In order to meet the image requirements of subsequent data processing software, the camera needs to have the adjustment functions of rotation and translation along the integration direction. At the same time, the deviation of the time-delay integration camera in the optical axis direction and the deviation of the time-delay integration camera in the length direction of the photosensitive area will affect the imaging quality of the time-delay integration camera. Summary of the Invention
[0004] This application provides a camera assembly and adjustment component, a gene sequencer, and a camera assembly and adjustment method.
[0005] In a first aspect, this application provides a camera mounting and adjustment assembly for adjusting the mounting position of a time-delay integration camera. The camera mounting and adjustment assembly includes:
[0006] frame; A three-dimensional adjustment assembly is mounted on the frame and is used to adjust the position of the time-delay integration camera along a first direction, a second direction, and a third direction; A pitch adjustment assembly is disposed on the three-dimensional adjustment assembly and is used to adjust the pitch angle of the time delay integration camera about the first direction; A rotary adjustment assembly is disposed on the pitch adjustment assembly and the time delay integration camera is mounted thereon, and is used to adjust the rotation angle of the time delay integration camera about the second direction; The first direction, the second direction, and the third direction are respectively the integration direction, the optical axis direction, and the length direction of the photosensitive area of the time-delay integration camera, and the first direction, the second direction, and the third direction are perpendicular to each other.
[0007] In one possible implementation, the pitch adjustment assembly includes a pitch adjustment plate, a pitch adjustment member, and a pitch locking member; The pitch locking member fixes the pitch adjustment plate to the three-dimensional adjustment assembly, and the pitch adjustment member is used to adjust the pitch angle of the pitch adjustment plate around the first direction.
[0008] In one possible implementation, the pitch adjustment component includes an adjustment rod and an adjustment seat corresponding to the adjustment rod; The adjusting rod is fixedly connected to the pitch adjustment plate, the adjusting seat is installed on the three-dimensional adjustment assembly, and the length of the adjusting rod can be extended or retracted to adjust the pitch angle of the pitch adjustment plate around the first direction.
[0009] In one possible implementation, the adjusting seat includes a first adjusting seat and a second adjusting seat spaced apart along a third direction; The number of the first adjustment seat is one, the number of the second adjustment seat is two, and the line connecting the two second adjustment seats is perpendicular to the third direction; The first adjusting seat has one of a conical groove and a V-shaped groove, and both second adjusting seats have the other of a conical groove and a V-shaped groove.
[0010] In one possible implementation, the pitch locking member includes a locking rod and an elastic element; The locking rod passes through the pitch adjustment plate and is connected to the three-dimensional adjustment assembly. The elastic element is sleeved on the locking rod to apply a spring force to the pitch adjustment plate in the direction close to the three-dimensional adjustment assembly.
[0011] In one possible implementation, the rotary adjustment assembly includes a rotary adjustment plate and a rotary adjustment member; The rotary mounting plate is assembled on the pitch mounting assembly and used to mount the time delay integration camera. The pitch mounting assembly has a light-transmitting hole, and the rotary mounting plate has a flange that mates with the light-transmitting hole. The rotary adjustment component is used to drive the rotary adjustment plate to rotate around the second direction.
[0012] In one possible implementation, the rotary adjustment member includes at least two sub-adjustment members, which are spaced apart circumferentially along the rotary adjustment plate. Each of the sub-adjustments is used to drive the rotary adjustment plate to rotate about the optical axis of the time delay integration camera, and at least two of the sub-adjustments are used to drive the rotary adjustment plate to rotate in opposite directions.
[0013] In one possible implementation, the rotary adjustment assembly further includes a rotary fixing member; The rotary adjustment plate has an arc-shaped waist-shaped hole, and the rotary fixing member passes through the arc-shaped waist-shaped hole and is used to fix the rotary adjustment plate to the pitch adjustment assembly.
[0014] In one possible implementation, the camera mounting assembly further includes a plurality of locking elements spaced apart; At least some of the locking members have opposite ends that are respectively lockably hinged to the three-dimensional adjustment assembly and the pitch adjustment assembly, and / or, at least some of the locking members have opposite ends that are respectively lockably hinged to the pitch adjustment assembly and the rotation adjustment assembly.
[0015] In one possible implementation, the three-dimensional assembly includes: The first assembly includes a first assembly plate and a first adjusting member; the frame has a loading surface, the first assembly plate is lockably slidably assembled on the frame along the first direction, and the first adjusting member is used to adjust the position of the first assembly plate along the first direction; The second assembly includes a second assembly plate and a second adjusting member; the second assembly plate has an adjusting plate and a bearing plate that are perpendicular to each other; the second assembly plate is slidably mounted on the first assembly plate along the second direction and the adjusting plate is in contact with the first assembly plate; the second adjusting member is used to adjust the position of the second assembly along the second direction. The third assembly includes a third assembly plate and a third adjusting member; the third assembly plate is lockably slidably assembled on the support plate along the third direction, and the third adjusting member is used to adjust the position of the third assembly plate along the third direction; The pitch adjustment assembly is located on the third adjustment plate.
[0016] In one possible implementation, at least one of the first adjusting member, the second adjusting member, and the third adjusting member includes a fixing member and a rotating member; the rotating member is rotatably connected to the corresponding fixing member. The fixing member is fixed to one of the frame and the first mounting plate, and the rotating member is threadedly connected to the other of the frame and the first mounting plate. The axis of the rotating member is parallel to a first direction, and the fixing member limits the rotation member in the first direction; and / or, The fixing member is fixed to one of the first and second mounting plates, and the rotating member is threadedly connected to the other of the first and second mounting plates. The axis of the rotating member is parallel to the second direction, and the fixing member limits the rotation member in the second direction; and / or, The fixing member is fixed to one of the second and third mounting plates, and the rotating member is threadedly connected to the other of the second and third mounting plates. The axis of the rotating member is parallel to the third direction, and the fixing member limits the rotating member in the third direction.
[0017] In one possible implementation, the camera mounting assembly further includes a first clamping member; One of the frame and the first mounting plate is provided with a first slide rod, and the other is provided with a first slide groove that cooperates with the first slide rod, and the first slide groove extends along the first direction. The first clamping member is used to apply a clamping force in a second direction to the first mounting plate.
[0018] In one possible implementation, the camera mounting assembly further includes a second clamping member; One of the first mounting plate and the second mounting plate is provided with a second slide rod, and the other is provided with a second slide groove that cooperates with the second slide rod, and the second slide groove extends along the second direction. The second clamping member is used to apply a clamping force in the first direction to the second mounting plate.
[0019] In one possible implementation, the camera mounting assembly further includes a magnetic element fixed to the second mounting plate and / or the third mounting plate, and used to apply a tensile force toward the support plate to the third mounting plate.
[0020] Secondly, this application provides a gene sequencer, including a gene sequencing fluid system, an optical detection system, and a computer system; wherein, The flow channel in the gene sequencing fluid system is inoculated with the sequencing sample library. The sequencing sample library comes into contact with the sequencing reagent and undergoes a chemical reaction so that the reaction product carries a fluorescent label. An optical detection system is configured to excite a fluorescent label carried by a reaction product and detect the fluorescence signal generated by the excitation of the fluorescent label to generate a fluorescence image; the optical detection system includes any of the camera assembly components described above and a time-delay integration camera, the time-delay integration camera being fixedly mounted on a rotary assembly plate. A computer system configured to acquire fluorescence images from an optical detection system and identify gene sequences of a sequenced sample library based on the fluorescence images.
[0021] Thirdly, this application provides a camera assembly and adjustment method, using any of the camera assembly and adjustment components described above, the camera assembly and adjustment method comprising the following steps: The time-delay integration camera is fixedly mounted to the rotary adjustment assembly; Adjust at least one of the three-dimensional adjustment component, the pitch adjustment component, and the rotation adjustment component until the photosensitive device of the time-delay integration camera is in a suitable position and orientation; The three-dimensional adjustment component, the pitch adjustment component, and the rotation adjustment component are locked together. Attached Figure Description
[0022] To more clearly illustrate the technical solutions of the embodiments of this disclosure, the accompanying drawings used in the embodiments will be briefly described below. These drawings are incorporated in and constitute a part of this specification. They illustrate embodiments conforming to this disclosure and, together with the specification, serve to explain the technical solutions of this disclosure. It should be understood that the following drawings only show some embodiments of this disclosure and should not be considered as limiting the scope. Those skilled in the art can obtain other related drawings based on these drawings without creative effort.
[0023] Figure 1 This is a schematic diagram of the camera assembly and adjustment components and the time delay integration camera provided in the embodiments of this application; Figure 2 This is a schematic diagram of the first adjusting member in an embodiment of this application; Figure 3 This is a schematic diagram of the rotary adjustment component in an embodiment of this application; Figure 4 This is a schematic diagram of the rotating adjustment plate in an embodiment of this application; Figure 5 This is a schematic diagram of the pitch adjustment component in an embodiment of this application; Figure 6 This is a schematic diagram of the clamping element in an embodiment of this application; Figure 7 This is a schematic diagram of the magnetic component in an embodiment of this application; Figure 8 This is a schematic diagram of the camera assembly and adjustment method in an embodiment of this application.
[0024] In the diagram, the components are: 0-time-delay integral camera, 1 frame, 11 loading surface, 21 first adjustment plate, 211 first inclined plane, 22 first adjustment component, 23 second adjustment plate, 231 adjustment plate, 232 bearing plate, 233 second inclined plane, 24 second adjustment component, 25 third adjustment plate, 26 third adjustment component, 27 first clamping component, 28 second clamping component, 3 pitch adjustment assembly, 31 pitch adjustment plate, 32 pitch adjustment component, 321 adjustment rod, 322 first adjustment seat, 323 second adjustment seat, 33 pitch locking component, 331 locking rod, 332 elastic component, 4 rotary adjustment assembly, 41 rotary adjustment plate, 411 flange, 412 waist-shaped hole, 42 rotary adjustment component, 421 sub-adjustment component, 43 rotary fixing component, 5 locking component, 6 magnetic component, 100 fixing component, 200 rotating component, 201 bolt head, and 202 limiting ring. Detailed Implementation
[0025] To make the objectives, technical solutions, and advantages of this application clearer, the application will now be described in further detail with reference to the accompanying drawings.
[0026] It should be noted that, unless otherwise defined, the technical or scientific terms used in one or more embodiments of this specification should have the ordinary meaning understood by one of ordinary skill in the art to which this disclosure pertains. The terms "first," "second," and similar words used in one or more embodiments of this specification do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Terms such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed following the word and their equivalents, without excluding other elements or objects. Terms such as "connected" or "linked" are not limited to physical or mechanical connections, but can include electrical connections, whether direct or indirect. Terms such as "upper," "lower," "left," and "right" are used only to indicate relative positional relationships; when the absolute position of the described object changes, the relative positional relationship may also change accordingly.
[0027] To facilitate understanding of the camera assembly and adjustment component, gene sequencer, and camera assembly and adjustment method provided in the embodiments of this application, their application scenarios are first described. The camera assembly and adjustment component provided in the embodiments of this application can be applied to a gene sequencer, while the camera assembly and adjustment method can be used to install and adjust a camera using the camera assembly and adjustment component.
[0028] With the continuous improvement of time delay integration (TDI) cameras in terms of resolution, line frequency, and other indicators, their use in gene sequencers is becoming increasingly common. As part of the optical detection system of gene sequencers, the assembly precision requirements for time delay integration cameras are extremely high.
[0029] Time-delay integration cameras have a strip-shaped photosensitive area. In order to meet the image requirements of subsequent data processing software, the camera needs to have the adjustment functions of rotation and translation along the integration direction. At the same time, the deviation of the time-delay integration camera in the optical axis direction and the deviation in the length direction of the photosensitive area will affect the image quality of the time-delay integration camera. The optical axis direction of the time-delay integration camera is its depth of focus direction.
[0030] Based on this, this application provides a camera adjustment assembly, which aims to enable the camera adjustment assembly to adjust the position of the time-delay integrating camera in the integration direction, optical axis direction, and photosensitive area length direction, and to enable the camera adjustment assembly to adjust the rotation angle of the time-delay integrating camera around its optical axis and integration direction. The camera adjustment assembly provided in this application will be described in detail below with reference to the accompanying drawings.
[0031] refer to Figures 1-6 , Figure 1 This is a schematic diagram of the camera assembly and adjustment components and the time delay integration camera provided in the embodiments of this application; Figure 2This is a schematic diagram of the first adjusting member in an embodiment of this application; Figure 3 This is a schematic diagram of the rotary adjustment component in an embodiment of this application; Figure 4 This is a schematic diagram of the rotating adjustment plate in an embodiment of this application; Figure 5 This is a schematic diagram of the pitch adjustment component in an embodiment of this application; Figure 6 This is a schematic diagram of the clamping element in an embodiment of this application.
[0032] The camera assembly provided in this embodiment includes a frame 1, a three-dimensional assembly, a pitch assembly 3, and a rotation assembly 4. The three-dimensional assembly is mounted on the frame 1, and both the pitch assembly 3 and the rotation assembly 4 are mounted on the three-dimensional assembly. The rotation assembly 4 also supports a time-delay integration camera 0. The three-dimensional assembly, the pitch assembly 3, and the rotation assembly 4 are used to adjust the position of the time-delay integration camera 0 in the integration direction, the optical axis direction, and the length of the photosensitive area, respectively, and to adjust the rotation of the time-delay integration camera 0 around its optical axis.
[0033] When the camera assembly is installed into the gene sequencer, the frame 1 acts as a carrier, responsible for placing the entire camera assembly into the optical detection system of the gene sequencer. The frame 1 itself has a mounting surface 11, which supports the three-dimensional assembly. The three-dimensional assembly device can be similar to a ball head gimbal or a 3D gimbal; the three-dimensional assembly is mounted on the frame 1 and is used to adjust the position of the time-delay integration camera 0 along the integration direction, the optical axis direction, and the length direction of the photosensitive area. For ease of description, as shown... Figure 1 As shown, the integration direction, optical axis direction, and length direction of the photosensitive area of the time-delay integration camera are defined as the first direction, the second direction, and the third direction, respectively. Here, the adjustment mechanisms of the time-delay integration camera 0 in the three directions of the three-dimensional adjustment device can be connected in series, all in parallel, or partially in parallel and partially in series.
[0034] As an optional implementation, the three-dimensional adjustment assembly includes a first adjustment assembly, a second adjustment assembly, and a third adjustment assembly. The first adjustment assembly is used to adjust the position of the time-delay integration camera 0 in a first direction, the second adjustment assembly is used to adjust the position of the time-delay integration camera 0 in a second direction, and the third adjustment assembly is used to adjust the position of the time-delay integration camera 0 in a third direction.
[0035] Specifically, the first assembly assembly includes a first assembly plate 21 and a first adjustment member 22. The first assembly plate 21 is slidably and lockably mounted on the loading surface 11, and the first adjustment member 22 is used to drive the first assembly plate 21 to slide along a first direction.
[0036] The first mounting plate 21 can be slidably mounted on the loading surface 11 by means of sliding rails, long oval holes of pins, etc., and can be locked relative to the loading surface 11 by means of thread locking, buckle locking, etc. The first adjusting member 22 acts between the first mounting plate 21 and the frame 1, and can drive the first mounting plate 21 to slide along the first direction by means of direct abutment push or thread transmission, etc.
[0037] The second assembly includes a second assembly plate 23 and a second adjusting member 24; the second assembly plate 23 has an adjusting plate 231 and a bearing plate 232 that are perpendicular to each other; the second assembly plate 23 is slidably fitted to the first assembly plate 21 and the adjusting plate 231 is in contact with the first assembly plate 21; the second adjusting member 24 is used to drive the second assembly to slide along a second direction.
[0038] Optionally, the second mounting plate 23 can be an integrally formed L-shaped plate or T-shaped plate, or it can be formed by welding, threaded connection or other means of two mutually perpendicular plates to form an L-shape or T-shape; of course, the adjusting plate 231 and the bearing plate 232 can also be two adjacent surfaces of a prism-shaped block material.
[0039] The second mounting plate 23 can be slidably assembled with the first mounting plate 21 through various means such as slide rails and long oval holes of pins, and can be locked relative to the first mounting plate 21 through various means such as threaded locking and buckle locking; the second adjusting member 24 acts between the second mounting plate 23 and the first mounting plate 21, and can drive the second mounting plate 23 to slide along the second direction through various means such as direct abutment and push or threaded transmission.
[0040] The third assembly includes a third assembly plate 25 and a third adjusting member 26; the third assembly plate 25 is lockably slidably mounted on the support plate 232, and the third adjusting member 26 is used to drive the third assembly plate 25 to slide along a third direction; The third mounting plate 25 can also be slidably assembled with the support plate 232 of the second mounting plate 23 through various means such as slide rails and long oval holes of pins, and can be locked relative to the support plate 232 of the second mounting plate 23 by various means such as threaded locking and buckle locking; the third adjusting member 26 acts between the third mounting plate 25 and the second mounting plate 23, and can drive the third mounting plate 25 to slide relative to the support plate 232 in a third direction through various means such as direct abutment and push or threaded transmission.
[0041] The pitch adjustment component 3 is disposed within the three-dimensional adjustment component, specifically in the third adjustment plate 25, and is used to adjust the pitch angle of the time-delay integration camera 0 around its integration direction, i.e., the first direction, that is, to adjust the pitch angle of the photosensitive element of the time-delay integration camera 0. The pitch angle of the photosensitive element is the pitch angle relative to the imaging plane, and this pitch angle will affect the parallelism between the photosensitive area and the imaging plane. For a time-delay integration camera, if the pitch angle deviation of the photosensitive element is large, it will cause a large difference in the distance between the two ends of the photosensitive area along its length direction and the area being photographed, which will easily lead to one side of the image being out of focus.
[0042] As an optional implementation, the pitch adjustment assembly 3 includes a pitch adjustment plate 31, a pitch adjustment component 32, and a pitch locking component 33; the pitch adjustment plate 31 is lockably mounted on the three-dimensional adjustment assembly, specifically, the pitch adjustment plate 31 is lockably mounted on the third adjustment plate 25; the pitch locking component 33 is used to fix the pitch adjustment plate 31 on the three-dimensional adjustment assembly, and the pitch adjustment component 32 is used to adjust the pitch angle of the pitch adjustment plate 31.
[0043] Optionally, the pitch adjustment component 32 is used to adjust at least one end of the pitch adjustment plate 31 along a third direction to move closer to or further away from the third adjustment plate 25. Specifically, the pitch adjustment component 32 can also be used to adjust at least one end of the pitch adjustment plate 31 along a third direction to move closer to or further away from the third adjustment plate 25 by direct contact or by threaded transmission. By providing the pitch adjustment assembly 3, the adjustment flexibility of the camera adjustment assembly for the integrating delay camera can be further improved, thereby meeting higher precision imaging requirements.
[0044] Please refer to the above. Figure 3 and Figure 5 .
[0045] As an optional implementation, the pitch adjustment component 32 includes an adjustment rod 321 and adjustment seats 322 and 323 corresponding to the adjustment rod 321; the adjustment rod 321 is fixedly connected to the pitch adjustment plate 31, and the adjustment seats 322 and 323 are installed on the three-dimensional adjustment assembly; the length of the adjustment rod 321 can be extended or retracted to adjust the pitch angle of the pitch adjustment plate 31.
[0046] Specifically, the adjusting seats 322 and 323 can be fixed to at least one end of the third adjusting plate 25 in the third direction; the adjusting rod 321 adjusts the pitch angle of the pitch adjusting plate 31 relative to the third adjusting plate 25 by extending and retracting its length.
[0047] As an optional implementation, when specifically setting the pitch adjustment member 32, the adjustment seats 322 and 323 include a first adjustment seat 322 and a second adjustment seat 323 spaced apart along a third direction, and each first adjustment seat 322 and the second adjustment seat 323 is provided with an adjustment rod 321 corresponding to each other.
[0048] The number of first adjusting seats 322 is one; the number of second adjusting seats 323 is two, and the line connecting the two second adjusting seats 323 is perpendicular to a third direction; that is, the line connecting the first adjusting seat 322 and the two second adjusting seats 323 forms a triangle, and the line connecting the two second adjusting seats 323 is parallel to the first direction. Further optionally, the line connecting the first adjusting seat 322 and the two second adjusting seats 323 can be set to form an isosceles triangle, with the line connecting the two second adjusting seats 323 being the base of the isosceles triangle.
[0049] One of the first adjusting seat 322 and the second adjusting seat 323 has a conical groove and the other has a V-shaped groove; the axial direction of the V-shaped groove is parallel to the third direction; the adjusting rod 321 is threaded to the pitch adjusting plate 31 and abuts against the corresponding conical groove and V-shaped groove. The V-shaped groove means that the cross-section of the groove on the adjusting seat is always V-shaped along the extension direction, while the conical groove means that the three-dimensional shape of the groove is conical.
[0050] The three adjusting rods 321 abutting against the corresponding first adjusting seat 322 and second adjusting seat 323 provide three fulcrums for the pitch adjustment plate 31, and the three fulcrums define a plane; therefore, the distance between the pitch adjustment plate 31 and the first adjusting seat 322 in the optical axis direction can be adjusted by rotating the adjusting rods 321, and / or the distance between the pitch adjustment plate 31 and the two second adjusting seats 323 in the optical axis direction can be adjusted by rotating the adjusting rods 321, thereby adjusting the pitch angle of the pitch adjustment plate 31, and thus adjusting the pitch angle of the time delay integration camera 0 about its integration direction.
[0051] When the adjusting rod 321 abuts against the conical groove, the conical groove can limit the adjusting rod 321 in the first direction and the third direction; when the adjusting rod 321 abuts against the V-groove, the V-groove can limit the adjusting rod 321 in the integral direction, but the adjusting rod 321 can slide in the third direction within the V-groove; this arrangement can reduce the risk of the adjusting rod 321 getting stuck with the adjusting seat when the pitch adjustment plate 31 is adjusted.
[0052] As an optional implementation, the pitch locking member 33 includes a locking rod 331 and an elastic member 332. The locking rod 331 passes through the pitch adjustment plate 31 and is connected to the three-dimensional adjustment assembly. The elastic member 332 is sleeved on the locking rod 331 to apply a spring force to the pitch adjustment plate 31 in the direction of the three-dimensional adjustment assembly. Optionally, the locking rod 331 is a bolt and the elastic member 332 is a compression spring. The bolt passes through the pitch adjustment plate 31 and is threadedly connected to the third adjustment plate 25. The compression spring is sleeved on the bolt, and its two ends abut against the bolt head 201 of the stable bolt and the pitch adjustment plate 31, respectively. Of course, in some embodiments, a washer may also be provided between the bolt head 201 of the stable bolt and the compression spring, and the compression spring may indirectly abut against the bolt head 201 of the stable bolt through the washer.
[0053] The rotation adjustment assembly 4 is disposed on the pitch adjustment assembly 3, and is used to mount the time delay integration camera 0 and to adjust the rotation angle of the time delay integration camera 0 around the optical axis of the time delay integration camera 0, i.e., the second direction.
[0054] As an optional implementation, the rotary adjustment assembly 4 includes a rotary adjustment plate 41 and a rotary adjustment member 42. The rotary adjustment plate 41 is used to mount the time-delay integration camera 0. Specifically, the rotary adjustment plate 41 can be mounted on the pitch adjustment assembly 3 and can rotate around the optical axis of the time-delay integration camera 0. Specifically, the rotary adjustment plate 41 can be mounted on the pitch adjustment plate 31. The rotary adjustment member 42 is used to drive the rotary adjustment plate 41 to rotate, specifically rotating around the optical axis of the integration delay camera. The pitch adjustment assembly 3 has a light-transmitting hole, which can be specifically formed on the pitch adjustment plate 31. The rotary adjustment plate 41 has a flange 411 that mates with the light-transmitting hole. The flange 411 engages with the light-transmitting hole and can limit the rotation of the rotary adjustment plate 41, thereby preventing the rotary adjustment plate 41 from deviating from the rotation center on its rotation plane.
[0055] The rotational connection between the rotary adjustment plate 41 and the pitch adjustment plate 31 can be directly or indirectly restricted by a track. The locking of the rotary adjustment plate 41 relative to the pitch adjustment plate 31 can also be directly or indirectly achieved by threaded locking, snap-locking, or other methods. The rotary adjustment component 42 can act directly or indirectly between the rotary adjustment plate 41 and the pitch adjustment plate 31, and can drive the rotary adjustment plate 41 to rotate by direct pushing, gear transmission, or other methods.
[0056] When the time-delay integration camera 0 is mounted on the rotating adjustment plate 41, it can be mounted on the side of the rotating adjustment plate 41 that is away from the pitch adjustment plate 31. The photosensitive area of the time-delay integration camera 0 can be positioned facing or away from the rotating adjustment plate 41. It is worth noting that when the photosensitive area of the time-delay integration camera 0 is facing the rotating adjustment plate 41, the rotating adjustment plate 41, the pitch adjustment plate 31, the third adjustment plate 25, and the second adjustment plate 23 are all provided with corresponding light-transmitting holes.
[0057] As an optional implementation, when the rotation adjustment member 42 is specifically set, the rotation adjustment member 42 includes at least two sub-adjustment members 421, and the at least two sub-adjustment members 421 are arranged at intervals along the circumference of the rotation adjustment plate 41; each sub-adjustment member 421 is used to drive the rotation adjustment plate 41 to rotate around the optical axis of the camera, and the at least two sub-adjustment members 421 are respectively used to drive the rotation adjustment plate 41 to rotate in opposite directions.
[0058] As a concrete example, such as Figure 3 and Figure 4 The rotary adjustment component 42 and rotary adjustment plate 41 shown are provided with an arc-shaped waist-shaped hole 412 on the rotary adjustment plate 41. The bolt passes through the waist-shaped hole 412 and is threaded to the pitch adjustment plate 31, so that a lockable rotary connection can be realized between the rotary adjustment plate 41 and the pitch adjustment plate 31.
[0059] There are two sub-adjustment members 421, which are spaced apart circumferentially along the pitch adjustment plate 31. Each sub-adjustment member 421 abuts against the rotary adjustment plate 41 and can drive the rotary adjustment plate 41 to rotate. When it is necessary to rotate the rotary adjustment plate 231, controlling one sub-adjustment member 421 to push against the other sub-adjustment member 421 and retract it will drive the rotary adjustment plate 231 to rotate. After rotating to the appropriate position, locking the sub-adjustment members 421 and the bolts passing through the oblong holes 412 will lock the rotary adjustment plate 41 and the pitch adjustment plate 31 together.
[0060] Such a rotating adjustment component 42 can achieve bidirectional, precise, and stable adjustment of the rotation angle of the integral delay camera, improving the accuracy of the rotation adjustment of the integral delay camera and the convenience of operation.
[0061] As an optional implementation, the rotary adjustment assembly 4 further includes a rotary fixing member 43; the rotary adjustment plate 41 has an arc-shaped waist-shaped hole 412, and the rotary fixing member 43 passes through the arc-shaped waist-shaped hole 412 and is used to fix the rotary adjustment plate 41 to the pitch adjustment assembly 3. Optionally, the center of the arc of the waist-shaped hole 412 is located on the straight line of the rotation axis of the rotary adjustment plate 41, so the sliding fit between the waist-shaped hole 412 and the rotary fixing member 43 does not conflict with the rotation of the rotary adjustment plate 41. During the rotation of the rotary adjustment plate 41, the waist-shaped hole 412 also slides relative to the rotary fixing member 43; after the rotary adjustment plate 41 rotates to a suitable position, the rotary fixing member 43 can be locked to limit the continued rotation of the rotary adjustment plate 41. Optionally, the rotary fixing member 43 can be a bolt, which is connected to the pitch adjustment plate 31 by a threaded connection, and the rotary adjustment plate 41 is locked by the rotating thread.
[0062] For the aforementioned camera assembly and adjustment components, after the time-delay integration camera 0 is assembled and fixed to the rotating assembly and adjustment plate 41, the translational position of the time-delay integration camera 0 in the integration direction, optical axis direction, and photosensitive area length direction can be adjusted using the three-dimensional assembly and adjustment components; the pitch angle of the time-delay integration camera 0 about its integration direction can be adjusted using the pitch assembly and adjustment components 3; and the rotation angle of the time-delay integration camera 0 about its optical axis direction can be adjusted using the rotation adjustment component 42. In summary, the camera assembly and adjustment components provided in this application can satisfy the position adjustment of the time-delay integration camera 0 in the integration direction, optical axis direction, and photosensitive area length direction, as well as the rotation and pitch adjustment of the time-delay integration camera 0, thereby meeting the high-precision assembly requirements of the time-delay integration camera 0, and have the characteristics of compact structure and high adjustment accuracy.
[0063] This application embodiment involves a first adjusting member 22, a second adjusting member 24, a third adjusting member 26, a rotation adjusting member 42, and a pitch adjusting member 32. The first adjusting member 22, the second adjusting member 24, and the third adjusting member 26 are all used for linear displacement adjustment, while the rotation adjusting member 42 and the pitch adjusting member 32 are used for rotational adjustment. The following details possible implementations of the first adjusting member 22, the third adjusting member 26, and the third adjusting member 26 involved in this application embodiment.
[0064] Please refer to the above. Figure 2 As an optional implementation, at least one of the first adjusting member 22, the second adjusting member 24 and the third adjusting member 26 in the embodiments of this application includes a fixing member 100 and a rotating member 200, wherein the rotating member 200 is rotatably connected to the corresponding fixing member 100.
[0065] Taking the case where the first adjusting member 22 includes a fixing member 100 and a rotating member 200 as an example, the fixing member 100 is fixed to one of the frame 1 and the first mounting plate 21, and the rotating member 200 is threadedly connected to the other of the frame 1 and the first mounting plate 21. The axis of the rotating member 200 is parallel to the first direction, and the fixing member 100 limits the rotating member 200 in the first direction. Figure 2 In one example shown, the fixing member 100 is fixed on the frame 1, the first adjustment plate 21 is provided with a threaded hole, the rotating member 200 is rotatably connected to the fixing member 100 and threadedly connected to the threaded hole of the first adjustment plate 21; during the adjustment process, rotating the rotating member 200 can cause the rotating member 200 to move forward and backward in the threaded hole, thereby pushing the first adjustment plate 21 to slide in the first direction.
[0066] Alternatively, when the second adjusting member 24 includes a fixing member 100 and a rotating member 200, the fixing member 100 is fixed to one of the first adjusting plate 21 and the second adjusting plate 23, and the rotating member 200 is threadedly connected to the other of the first adjusting plate 21 and the second adjusting plate 23. The axis of the rotating member 200 is parallel to the second direction, and the fixing member 100 limits the rotating member 200 in the second direction.
[0067] Alternatively, when the third adjusting member 26 includes a fixing member 100 and a rotating member 200, the fixing member 100 is fixed to one of the second adjusting plate 23 and the third adjusting plate 25, and the rotating member 200 is threadedly connected to the other of the second adjusting plate 23 and the third adjusting plate 25. The axis of the rotating member 200 is parallel to the third direction, and the fixing member 100 limits the rotating member 200 in the third direction.
[0068] It is worth noting that any one, two, or all three of the first adjusting member 22, the second adjusting member 24, and the third adjusting member 26 can be in the same way as described above, where the rotating member 200 and the fixed member 100 are engaged.
[0069] As a concrete example, such as Figure 2 In the rotating member 200 and the fixed member 100 shown, the fixed member 100 is provided with a receiving groove with a side opening, and the rotating member 200 is a bolt with a limiting ring 202. The bolt is placed into the receiving groove through the side opening of the receiving groove to realize the rotational connection between the rotating member 200 and the fixed member 100. At the same time, the limiting ring 202 and the bolt head 201 restrict the displacement of the bolt in the first direction.
[0070] The adjustment method that uses the rotating part 200 and the fixed part 100 provides a compact, backlash-free, and highly accurate linear drive method, which effectively avoids position disturbances during the adjustment process and improves the adjustment accuracy and stability of the time delay integration camera 0.
[0071] As an optional implementation method, refer to Figure 6 The camera assembly includes a first slide rod on one of the frame 1 and the first mounting plate 21, and a first sliding groove on the other, which cooperates with the first slide rod and extends in a first direction. The sliding engagement between the first slide rod and the first sliding groove enables the sliding engagement between the first mounting plate 21 and the frame 1. The camera assembly also includes a first clamping member 27, which applies a clamping force in a second direction to the first mounting plate 21.
[0072] Specifically, the first clamping element 27 can be a spring, a spring sheet, or a magnet, or it can be secured by a thread to provide continuous pressure. By setting the first clamping element 27, it can be ensured that the first slide rod is always pressed against one side wall of the first slide groove, thereby eliminating the gap between the first slide rod and the side wall of the first slide groove, improving the sliding stability and positioning accuracy of the first mounting plate 21, and reducing the impact of the gap in the sliding connection mechanism between the first mounting plate 21 and the frame 1 in the second direction on the adjustment accuracy of the camera mounting assembly.
[0073] Optionally, the first clamping member 27 also applies a clamping force to the first mounting plate 21 along the direction toward the frame 1. (Continued reference) Figure 6 For the first mounting plate 21 and the frame 1, the first clamping member 27 is fixed to the frame 1 and applies pressure to the first inclined surface 211 on the first mounting plate 21, so that the first clamping member 27 simultaneously applies pressure to the first mounting plate 21 against the frame 1 and pressure in the second direction. The pressure towards the frame 1 ensures that the bottom surface of the first mounting plate 21 is always in close contact with the loading surface 11 of the frame 1, eliminating the gap between them and improving the stability after sliding.
[0074] By applying a continuous preload force through the first clamping member 27, the gap between the mating surfaces of the first mounting plate 21 and the frame 1 can be eliminated, thereby improving the overall rigidity and stability of the component connection. This can effectively suppress any shaking or vibration that may occur during the adjustment process and improve the adjustment accuracy of the camera mounting assembly.
[0075] As an optional implementation, one of the first mounting plate 21 and the second mounting plate 23 is provided with a second slide rod, and the other is provided with a second slide groove that cooperates with the second slide rod, the second slide groove extending along a second direction; the second slide rod and the second slide groove slide into each other to achieve a sliding engagement between the first mounting plate 21 and the frame 1. The camera mounting assembly also includes a second clamping member 28; the second clamping member 28 is used to apply a clamping force in a first direction to the second mounting plate 23.
[0076] Specifically, the second clamping element 28 can be a spring, a spring sheet, or a magnet, or it can utilize a threaded locking mechanism to provide continuous pressure. By providing the second clamping element 28, it is ensured that the second slide rod always abuts against one side wall of the second slide groove, thereby eliminating the gap between the second slide rod and the side wall of the second slide groove. This improves the sliding stability and positioning accuracy of the second mounting plate 23, and reduces the impact of the gap in the sliding connection mechanism between the second mounting plate 23 and the first mounting plate 21 in the first direction on the adjustment accuracy of the camera mounting assembly.
[0077] Optionally, the second clamping member 28 also applies a clamping force to the second mounting plate along the direction toward the frame 1. (Continued reference) Figure 6 For the second mounting plate 23 and the first mounting plate 21, the second clamping member 28 is fixed to the frame 1 and applies pressure to the second inclined surface 233 on the second mounting plate 23, so that the second clamping member 28 simultaneously applies pressure to the second mounting plate 23 against the frame 1 and pressure along the first direction. The pressure towards the frame 1 ensures that the bottom surface of the second mounting plate 23 is always in close contact with the first mounting plate 21, eliminating the gap between them and improving the stability after sliding.
[0078] By applying a continuous preload through the second clamping member 28, the gap between the mating surfaces of the second mounting plate 23 and the first mounting plate 21 can be eliminated, thereby improving the overall rigidity and stability of the component connection. This can effectively suppress any shaking or vibration that may occur during the adjustment process and improve the adjustment accuracy of the camera mounting assembly.
[0079] refer to Figure 7 , Figure 7 This is a schematic diagram of the magnetic component in an embodiment of this application.
[0080] As an optional implementation, the camera mounting assembly also includes a magnetic element 6, which is fixed to the second mounting plate 23 and / or the third mounting plate 25 and is used to apply a pulling force toward the support plate 232 to the third mounting plate 25.
[0081] As an example, such as Figure 7 The magnetic component 6 shown is fixed to the second mounting plate 23; specifically, a groove is provided on the bearing plate 232 of the second mounting plate 23, and the magnetic component 6 is fixed in the groove.
[0082] By applying a continuous pulling force towards the support plate 232 to the third mounting plate 25 using the magnetic component 6, the back of the third mounting plate 25 is always tightly attached to the support plate 232. This reduces the gap between the third mounting plate 25 and the support plate 232, improves the tightness and stability of the third mounting plate 25 on the support plate 232, and thus improves the positional accuracy of the camera in the optical axis direction.
[0083] As an alternative implementation method, continue to refer to Figure 1 The camera mounting assembly also includes a plurality of locking members 5 spaced apart; at least some of the locking members 5 are respectively hinged and locked to the third mounting plate 25 and the pitch mounting plate 31, and / or, at least some of the locking members 5 are respectively hinged and locked to the rotation mounting plate 41 and the pitch mounting plate 31.
[0084] Specifically, the camera mounting assembly provided in this application embodiment may have a locking member 5 provided only between the third mounting plate 25 and the pitch mounting plate 31, or a locking member 5 provided only between the pitch mounting plate 31 and the rotation mounting plate 41, or a locking member 5 provided simultaneously between the third mounting plate 25 and the pitch mounting plate 31 and between the pitch mounting plate 31 and the rotation mounting plate 41.
[0085] In a specific example, taking the locking element 5 located between the third mounting plate 25 and the pitch mounting plate 31 as an example, the locking element 5 is elongated, and its two ends are fixed to the side of the third mounting plate 25 and the side of the pitch mounting plate 31 respectively by bolts. When adjusting the position of the pitch mounting plate 31, the bolts can be kept in a loose state. At this time, the locking element 5 is hinged to the third mounting plate 25 and the pitch mounting plate 31 respectively with the corresponding bolt as the axis. After the position adjustment is completed, the bolts can be tightened to lock the locking element 5 to the third mounting plate 25 and the pitch mounting plate 31 respectively. The multiple locking elements 5 arranged at intervals work together to improve the structural stability when the third mounting plate 25 and the pitch mounting plate 31 are locked together, thereby further improving the structural stability and positioning accuracy of the camera mounting assembly.
[0086] This application also provides a gene sequencer, including a gene sequencing fluid system, an optical detection system, and a computer system; wherein, The flow channel in the gene sequencing fluid system is inoculated with the sequencing sample library. The sequencing sample library comes into contact with the reagent and undergoes a chemical reaction so that the reaction product carries a fluorescent label. An optical detection system is configured to excite a fluorescent label carried by a reaction product and detect the fluorescence signal generated by the excitation of the fluorescent label to generate a fluorescence image; the optical detection system includes any of the camera assembly components described above and a time-delay integration camera, the time-delay integration camera being fixedly mounted on a rotary assembly plate. A computer system configured to acquire fluorescence images from an optical detection system and identify gene sequences of a sequenced sample library based on the fluorescence images.
[0087] The camera assembly and adjustment components in the aforementioned gene sequencer can meet the positional adjustment of the time-delay integration camera in the integration direction, optical axis direction, and photosensitive area length direction, as well as the rotational adjustment of the time-delay integration camera, thereby meeting the high-precision assembly requirements of the time-delay integration camera, and featuring compact structure and high adjustment accuracy.
[0088] refer to Figure 8 , Figure 8 This is a schematic diagram of the camera assembly and adjustment method in an embodiment of this application.
[0089] This application also provides a camera assembly and adjustment method, using any of the camera assembly and adjustment components described above. The camera assembly and adjustment method includes the following steps: S1. Securely mount the time-delay integration camera to the rotary mounting assembly. Specifically, the time-delay integration camera can be secured to the rotary mounting plate using various methods such as bonding, snap-fitting, or connecting with threaded fasteners.
[0090] S2. Adjust at least one of the three-dimensional adjustment assembly, the pitch adjustment assembly, and the rotation adjustment component until the photosensitive device of the time-delay integration camera is in a suitable position and orientation. Specifically, the position of the time-delay integration camera in the integration direction and optical axis direction can be adjusted by adjusting the first and second adjustment components, the position of the time-delay integration camera in the length direction of the photosensitive area can be adjusted by adjusting the third adjustment component, and the rotation attitude of the time-delay integration camera can be adjusted by adjusting the rotation adjustment component. Optionally, when the camera adjustment assembly also includes a pitch adjustment assembly, the pitch attitude of the time-delay integration camera can also be adjusted by adjusting the pitch adjustment component.
[0091] S3. Lock the three-dimensional adjustment component, the pitch adjustment component, and the rotation adjustment component together.
[0092] The camera assembly and adjustment components used in the above-mentioned camera assembly and adjustment method can meet the position adjustment of the time-delay integrating camera in the integration direction, optical axis direction and photosensitive area length direction, as well as the rotation adjustment of the time-delay integrating camera, thereby meeting the high-precision assembly requirements of the time-delay integrating camera, and have the characteristics of compact structure and high adjustment accuracy.
[0093] One or more embodiments of this specification are intended to cover all such substitutions, modifications, and variations that fall within the broad scope of the appended claims. Therefore, any omissions, modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of one or more embodiments of this specification should be included within the scope of protection of this disclosure.
[0094] The above are merely specific embodiments of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.
Claims
1. A camera mounting and adjusting assembly for adjusting the mounting position of a time-delay integration camera, characterized in that: The camera assembly includes: frame; A three-dimensional adjustment assembly is mounted on the frame and is used to adjust the position of the time-delay integration camera along a first direction, a second direction, and a third direction; A pitch adjustment assembly is disposed on the three-dimensional adjustment assembly and is used to adjust the pitch angle of the time delay integration camera about the first direction; A rotary adjustment assembly is disposed on the pitch adjustment assembly and the time delay integration camera is mounted thereon, and is used to adjust the rotation angle of the time delay integration camera about the second direction; The first direction, the second direction, and the third direction are respectively the integration direction, the optical axis direction, and the length direction of the photosensitive area of the time-delay integration camera, and the first direction, the second direction, and the third direction are perpendicular to each other.
2. The camera mounting and adjusting assembly according to claim 1, characterized in that, The pitch adjustment assembly includes a pitch adjustment plate, a pitch adjustment component, and a pitch locking component; The pitch locking member fixes the pitch adjustment plate to the three-dimensional adjustment assembly, and the pitch adjustment member is used to adjust the pitch angle of the pitch adjustment plate around the first direction.
3. The camera mounting and adjusting assembly according to claim 2, characterized in that, The pitch adjustment component includes an adjustment rod and an adjustment seat corresponding to the adjustment rod; The adjusting rod is fixedly connected to the pitch adjustment plate, the adjusting seat is installed on the three-dimensional adjustment assembly, and the length of the adjusting rod can be extended or retracted to adjust the pitch angle of the pitch adjustment plate around the first direction.
4. The camera mounting and adjusting assembly according to claim 3, characterized in that, The adjustment seat includes a first adjustment seat and a second adjustment seat that are spaced apart along a third direction; The number of the first adjustment seat is one, the number of the second adjustment seat is two, and the line connecting the two second adjustment seats is perpendicular to the third direction; The first adjusting seat has one of a conical groove and a V-shaped groove, and both second adjusting seats have the other of a conical groove and a V-shaped groove.
5. The camera mounting and adjusting assembly according to claim 4, characterized in that, The pitch locking component includes a locking rod and an elastic element; The locking rod passes through the pitch adjustment plate and is connected to the three-dimensional adjustment assembly. The elastic element is sleeved on the locking rod to apply a spring force to the pitch adjustment plate in the direction close to the three-dimensional adjustment assembly.
6. The camera mounting and adjusting assembly according to claim 1, characterized in that, The rotary adjustment assembly includes a rotary adjustment plate and a rotary adjustment component; The rotary mounting plate is assembled on the pitch mounting assembly and used to mount the time delay integration camera. The pitch mounting assembly has a light-transmitting hole, and the rotary mounting plate has a flange that mates with the light-transmitting hole. The rotary adjustment component is used to drive the rotary adjustment plate to rotate around the second direction.
7. The camera mounting and adjusting assembly according to claim 6, characterized in that, The rotary adjustment component includes at least two sub-adjustment components, which are spaced apart circumferentially along the rotary adjustment plate. Each of the sub-adjustments is used to drive the rotary adjustment plate to rotate about the optical axis of the time delay integration camera, and at least two of the sub-adjustments are used to drive the rotary adjustment plate to rotate in opposite directions.
8. The camera mounting and adjusting assembly according to claim 7, characterized in that, The rotary adjustment assembly also includes a rotary fixing component; The rotary adjustment plate has an arc-shaped waist-shaped hole, and the rotary fixing member passes through the arc-shaped waist-shaped hole and is used to fix the rotary adjustment plate to the pitch adjustment assembly.
9. A gene sequencer, characterized in that, This includes a gene sequencing fluid system, an optical detection system, and a computer system; among which, The flow channel of the gene sequencing fluid system receives the sequencing sample library, which comes into contact with the sequencing reagent and undergoes a chemical reaction so that the reaction product carries a fluorescent label. The optical detection system is configured to excite the fluorescent label carried by the reaction product and detect the fluorescence signal generated by the excitation of the fluorescent label to generate a fluorescence image; the optical detection system includes a camera assembly as described in any one of claims 1 to 8 and a time-delay integration camera, wherein the time-delay integration camera is fixedly mounted on the rotary assembly plate. The computer system is configured to acquire fluorescence images from the optical detection system and identify gene sequences of the sequenced sample library based on the fluorescence images.
10. A camera mounting and adjustment method, characterized in that, The camera assembly and adjustment method, using the camera assembly and adjustment component as described in any one of claims 1 to 8, comprises the following steps: The time-delay integration camera is fixedly mounted to the rotary adjustment assembly; Adjust at least one of the three-dimensional adjustment component, the pitch adjustment component, and the rotation adjustment component until the photosensitive device of the time-delay integration camera is in a suitable position and orientation; The three-dimensional adjustment component, the pitch adjustment component, and the rotation adjustment component are locked together.