A safe quinclorac preparation and application thereof

Abstract

The present application relates to the technical field of herbicides, in particular to a safe quinclorac preparation and application. The safe quinclorac preparation contains active ingredients and adjuvants, and the adjuvant contains a high molecular flocculating agent, wherein the high molecular flocculating agent accounts for 0.1-20% of the mass of the preparation; the active ingredients contain quinclorac. The anti-leaching safe quinclorac provided in the present application is combined with the high molecular flocculating agent, and the safe quinclorac preparation composition not only improves the activity of quinclorac, but also greatly reduces crop phytotoxicity and improves the safety to crops, and is economic and environmentally friendly.

Description

Technical Field

[0001] This invention relates to the field of herbicide technology, and in particular to a safe quinclorac formulation and its application. Background Technology

[0002] Quinaloxone is a novel class of p-hydroxyphenylpyruvate dioxidase inhibitors (HPPDs) herbicides, characterized by high efficiency, broad spectrum, safety, low toxicity, and environmental friendliness. Quinaloxone exhibits highly effective herbicidal activity against a variety of broadleaf and grass weeds.

[0003] Most soil-applied herbicides are absorbed through plant roots and act on weed roots while remaining in the soil surface. However, different application methods can affect the migration rate of quinclorac in the soil, leading to severe soil leaching and causing crop damage. Therefore, this invention aims to develop a safe quinclorac formulation composition to inhibit crop damage caused by downward leaching, improve the safety of herbicides for crops, and achieve safe and efficient utilization of quinclorac. Summary of the Invention

[0004] The purpose of this invention is to provide a safe quinacrine formulation and its application.

[0005] To achieve the above objectives, the present invention adopts the following technical solution:

[0006] A safe quinacrine formulation, comprising an active ingredient and adjuvants, wherein the adjuvants include a polymeric flocculant, wherein the polymeric flocculant accounts for 0.1-20% of the formulation mass; and the active ingredient contains quinacrine.

[0007] The polymeric flocculant is one or more of the following: inorganic polymeric flocculant, organic polymeric flocculant, cationic organic polymeric flocculant, anionic organic polymeric flocculant, and nonionic organic polymeric flocculant.

[0008] Preferably, the inorganic polymeric flocculant is selected from polyaluminum sulfate, polyaluminum chloride, polyferric sulfate, and polyferric chloride; the organic polymeric flocculant is selected from polyacrylamide, sulfonated polyvinylbenzene, and polyvinyl ether, or more; the cationic organic polymeric flocculant is selected from polyacrylamide and its derivatives, homopolymers of dimethyl diallyl ammonium chloride (DMDAAC) and copolymers with acrylamide (AM), copolymers of vinyltrimethoxysilane (VYMS) and (DMDAAC), and polyimide, or more; the anionic organic polymeric flocculant is selected from sodium polyacrylate, copolymers of acrylamide and sodium acrylate, and sodium polystyrene sulfonate, or more; and the nonionic organic polymeric flocculant is selected from nonionic polyacrylamide, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyvinyl methyl ether, and polyalkylphenol-ethylene oxide, or more.

[0009] Further preferably, the polymeric flocculant is polymeric flocculant A and / or polymeric flocculant B, wherein polymeric flocculant A is a polymeric flocculant with a molecular weight of 1,000,000 to 5,000,000 (preferably, polymeric flocculant A is a polymeric flocculant with a molecular weight of 100,000 to 10,000,000); and polymeric flocculant B is a polymeric flocculant with a molecular weight of 35,000 to 150,000 (polymeric flocculant B is a polymeric flocculant with a molecular weight of 25,000 to 150,000).

[0010] In a further preferred embodiment, when the polymeric flocculant is polymeric flocculant A and polymeric flocculant B, the mass ratio of polymeric flocculant A to polymeric flocculant B is 1:0.1 to 10.

[0011] More preferably, when the polymeric flocculant is polymeric flocculant A and polymeric flocculant B, the ratio of polymeric flocculant A to polymeric flocculant B is 1:0.1 to 5. More preferably, when the polymeric flocculant is polymeric flocculant A and polymeric flocculant B, the ratio of polymeric flocculant A to polymeric flocculant B is 1:0.1 to 2.

[0012] The additives are one or more of the following: emulsifiers, dispersants, wetting agents, spreading agents, stabilizers, defoamers, synergists, penetrants, adhesives, safety agents, carriers, and fillers.

[0013] The formulation is a wettable powder, emulsifiable concentrate, soluble concentrate, aqueous solution, oil suspension, water suspension, water-dispersible granule, dry suspension, water emulsion, microemulsion, floating granule, effervescent agent, or large granule.

[0014] When the formulation is an emulsifiable concentrate, the polymeric flocculant accounts for 0.1-10% by weight of the formulation;

[0015] When the formulation is an aqueous solution, the polymeric flocculant accounts for 0.1-5% by weight of the formulation;

[0016] When the formulation is an aqueous suspension, the polymeric flocculant accounts for 0.1-1% of the formulation by weight.

[0017] The aforementioned safe quinalazine formulation involves the addition of a polymeric flocculant. The flocculant, through stirring, causes the uncharged particles to come into contact with each other and aggregate, promoting the formation of a flocculent system. The polymeric flocculant is also a synthetic polyelectrolyte. Through a bridging reaction, it generates a colloidal double layer effect. When two colloidal particles in water collide, the mutual attraction overcomes the repulsion and diffusion energy, causing the two colloids to combine and form a flocculated state. This inhibits soil leaching and increases crop safety.

[0018] Application of a safe quinacrine formulation, wherein the safe quinacrine formulation is used in crop fields for weed control and for inhibiting quinacrine leaching.

[0019] The crops mentioned are sorghum, wheat, corn, sugarcane, and cotton.

[0020] The crop in question is cotton used for drip irrigation in the Xinjiang region.

[0021] The weeds are broadleaf weeds and grass weeds; preferably, the weeds are selected from one or more annual weeds such as black nightshade, wild millet, crabgrass, barnyard grass, goosegrass, foxtail grass, wild millet, lambsquarters, velvetleaf, reverse-branch amaranth, dayflower, purslane, and cocklebur.

[0022] Advantages of this invention:

[0023] The safe quinacrine formulation of this invention can effectively retain quinacrine in the weed layer soil, limiting the migration rate of the herbicide in the crop layer soil, thereby further inhibiting the leaching of quinacrine into the crop layer, preventing phytotoxicity to crops, and improving crop safety.

[0024] The formulation of this invention can increase the amount of herbicide used while ensuring crop safety, improve the control efficacy, reduce the cost of application, improve crop safety, and increase crop yield and quality compared with the use of other herbicides, thus having great social and economic benefits. Detailed Implementation

[0025] The following provides a detailed description of specific embodiments of the present invention. It should be understood that the specific embodiments described herein are for illustrative and explanatory purposes only and are not intended to limit the scope of the invention.

[0026] The leaching-resistant and safe quinclorac provided by this invention utilizes the polar amide groups of the polymeric flocculant. These groups adsorb onto the surface of sediment particles through hydrogen bonding. The long molecular chains bridge the particles, causing double-ionization compression, which reduces particle aggregation stability. The particles then bind together under molecular attraction, and the dispersed phase is replaced by polymeric groups, increasing the adsorption surface area, thus achieving flocculation and anti-leaching effects. When this type of polymeric flocculant is added to a quinclorac formulation system, it effectively enhances the adsorption of quinclorac in the weed layer soil, reduces the migration rate of quinclorac in the weed layer soil, minimizes soil leaching, and reduces residues in the crop layer soil, thereby improving crop safety. This safe quinclorac formulation composition not only enhances quinclorac activity but also significantly reduces crop phytotoxicity, improving crop safety and being economically and environmentally friendly.

[0027] The present invention will be further illustrated below with reference to the embodiments:

[0028] (I) Soil leaching experiment of different safety profiles of quinclorac formulations

[0029] Example 1: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is polymeric flocculant A, namely cationic polyacrylamide (CPAM).

[0030] Experimental method: After mixing the raw materials evenly in the shearing kettle as described above, the mixture was then transferred to a sand mill for fine grinding until the material was qualified. The material was then discharged and packaged to obtain a 10% quinacrine suspension (quinacrine SC) sample.

[0031] Accurately weigh 1g of 10% quinclorac SC into a 50mL beaker, dissolve and shake well. Fill a glass column with air-dried and sieved soil to a height of 30cm. Soak 20g of soil in a 1g 10% quinclorac SC solution overnight and place it on top of the soil. Leach with 150-250ml of distilled water at a rate of 20ml / h. After leaching, divide the soil into 4 sections. After mixing each section, weigh 20.0g of the mixture and add it to methanol + water (V:V = 8:2). Mix and sonicate for 2h. Filter the supernatant through a 0.45µm filter membrane for HPLC analysis.

[0032] Example 2: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is polymeric flocculant B, namely polyvinyl alcohol (PVA).

[0033] The processing method is the same as in Example 1.

[0034] Example 3: Prepare the following raw materials by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5, i.e., polymeric flocculant A is cationic polyacrylamide (CPAM), and polymeric flocculant B is polyvinyl alcohol (PVA).

[0035] The processing method is the same as in Example 1.

[0036] Example 4: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is prepared by mixing composition A (cationic polyacrylamide) and composition B (polyvinyl alcohol) in a 1:1 weight ratio.

[0037] The processing method is the same as in Example 1.

[0038] Example 5: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:1.5, i.e., polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0039] The processing method is the same as in Example 1.

[0040] Example 6: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:2; that is, polymeric flocculant A is cationic polyacrylamide (CPAM), and polymeric flocculant B is polyvinyl alcohol (PVA).

[0041] The processing method is the same as in Example 1.

[0042] Example 7: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:3; that is, polymeric flocculant A is cationic polyacrylamide (CPAM), and polymeric flocculant B is polyvinyl alcohol (PVA).

[0043] The processing method is the same as in Example 1.

[0044] Example 8: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 3:2; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0045] The processing method is the same as in Example 1.

[0046] Example 9: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 3:1; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0047] The processing method is the same as in Example 1.

[0048] Comparative Example 1:

[0049] Prepare the following raw materials by weight: 10 parts quinacrine, 0.2 parts naphthalenesulfonic acid formaldehyde polymer, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalenesulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinacrine suspension sample.

[0050] The processing method is the same as in Example 1.

[0051] Comparative Example 2:

[0052] Prepare the following raw materials by weight: 10 parts quinacrine, 0.2 parts sodium methylene bis(naphthalene) sulfonate, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinacrine suspension sample.

[0053] The processing method is the same as in Example 1.

[0054] Comparative Example 3:

[0055] Prepare the following raw materials by weight: 10 parts quinacrine, 0.2 parts C12-16 alkyl polyoxyethylene polyoxypropylene ether (leaching solvent), 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinacrine suspension sample.

[0056] The processing method is the same as in Example 1.

[0057] Comparative Example 4:

[0058] Prepare the following raw materials by weight: 10 parts quinacrine, 0.2 parts isomeric tridecyl alcohol polyoxyethylene ether (leaching solvent), 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5.0 parts antifreeze, and 73.8 parts water to obtain a 10% quinacrine suspension sample.

[0059] The processing method is the same as in Example 1.

[0060] Example: Determination of quinacrine concentration in soil

[0061] The soil was divided into four sections: 0-3cm, 3-7cm, 7-15cm, and 15-30cm. The leaching properties of 10% quinclorac SC in the soil at the first three depths were tested in the above-described examples and comparative examples.

[0062] Meanwhile, the soil was replaced with sand, and the leaching properties of 10% quinclorac SC in the above examples and comparative examples were tested.

[0063] The mass percentage of quinacrine, X, is calculated according to formula (1).

[0064]

[0065] In the formula: A1—peak area of ​​quinacrine

[0066] ∑A — the sum of the peak areas of each component

[0067] The liquid phase analysis of 10% quinclorac SC in soil is shown in the table below:

[0068] The concentration ratios of quinacrine provided in Examples 1-9 and Comparative Examples 1-4 were determined in different soils and at different depths. Table 1 shows the distribution results of quinacrine in sandy soil, and Table 2 shows the distribution results of quinacrine in loam.

[0069]

[0070]

[0071]

[0072] Analysis of the data in Tables 1 and 2 shows that quinclorac containing polymeric flocculants exhibited inhibitory effects on leaching in both sandy and loamy soil environments. Specifically, when polymeric flocculants A and B were combined in a specific ratio, the resulting composition demonstrated superior inhibitory effects on quinclorac leaching compared to either flocculant (A or B) alone. This indicates a synergistic effect between the two components, which jointly enhanced the inhibitory capacity for quinclorac leaching. Under individual use, polymeric flocculant A showed significantly better inhibitory effects on quinclorac leaching than polymeric flocculant B.

[0073] (II) Leachability Experiment of Polymer Flocculant Compositions of Different Concentrations in Soil

[0074] Example 10: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.1 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.9 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0075] Experimental method: After the raw materials described above are put into the shearing kettle and mixed evenly, they are transferred to the sand mill for fine grinding until the material is qualified. The material is then discharged and packaged to obtain a 10% quinacrine suspension (10% quinacrine SC) sample.

[0076] Accurately weigh 1g of 10% quinclorac SC into a 50mL beaker, dissolve and shake well. Fill a glass column with air-dried and sieved soil to a height of 30cm. Soak 20g of soil in a 1g 10% quinclorac SC solution overnight and place it on top of the soil. Leach with 150-250ml of distilled water at a rate of 20ml / h. After leaching, divide the soil into 4 sections. Mix each section thoroughly and weigh 20.0g of the mixture. Add methanol and water (V:V = 8:2), mix, and sonicate for 2h. Filter the supernatant through a 0.45µm filter membrane for HPLC analysis.

[0077] Example 11: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.2 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.8 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0078] The processing method is the same as in Example 10.

[0079] Example 12: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.3 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.7 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0080] The processing method is the same as in Example 10.

[0081] Example 13: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.4 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.6 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0082] The processing method is the same as in Example 10.

[0083] Example 14: Prepare the following raw materials in parts by weight: 10 parts quinclorac, 0.5 parts polymeric flocculant composition, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.5 parts water to obtain a 10% quinclorac suspension sample. The polymeric flocculant is composed of polymeric flocculant A and polymeric flocculant B in a weight ratio of 1:0.5; that is, polymeric flocculant A is cationic polyacrylamide (CPAM) and polymeric flocculant B is polyvinyl alcohol (PVA).

[0084] The processing method is the same as in Example 10.

[0085] Comparative Example 5:

[0086] Prepare the following raw materials by weight: 10 parts quinacrine, 0.1 parts alkylaryl sulfonic acid, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.9 parts water to obtain a 10% quinacrine suspension sample.

[0087] The processing method is the same as in Example 10.

[0088] Comparative Example 6:

[0089] Prepare the following raw materials by weight: 10 parts quinacrine, 0.2 parts alkylaryl sulfonic acid, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.8 parts water to obtain a 10% quinacrine suspension sample.

[0090] The processing method is the same as in Example 10.

[0091] Comparative Example 7:

[0092] Prepare the following raw materials by weight: 10 parts quinacrine, 0.3 parts alkyl aryl sulfonic acid, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.7 parts water to obtain a 10% quinacrine suspension sample.

[0093] The processing method is the same as in Example 10.

[0094] Comparative Example 8:

[0095] Prepare the following raw materials by weight: 10 parts quinacrine, 0.4 parts alkylaryl sulfonic acid, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.6 parts water to obtain a 10% quinacrine suspension sample.

[0096] The processing method is the same as in Example 10.

[0097] Comparative Example 9:

[0098] Prepare the following raw materials by weight: 10 parts quinacrine, 0.5 parts alkylaryl sulfonic acid, 6.0 parts hydrophobic modified carboxylic acid copolymer Agrilan788, 4.0 parts alkyl naphthalene sulfonate condensate Morwet D-425, 1 part organobentonite, 5 parts antifreeze, and 73.5 parts water to obtain a 10% quinacrine suspension sample.

[0099] The processing method is the same as in Example 10.

[0100] The liquid phase analysis of 10% quinclorac SC in soil is shown in the table below:

[0101] The concentration ratios of quinacrine provided in Examples 10-14 and Comparative Examples 5-9 were determined in different soils and at different depths. Table 3 shows the distribution results of quinacrine in sandy soil, and Table 4 shows the distribution results of quinacrine in loam.

[0102]

[0103]

[0104]

[0105] Analysis of the data in Tables 3 and 4 shows that the optimal leaching inhibition effect of quinclorac was achieved when the polymeric flocculant accounted for 0.2% by weight of the formulation. This finding highlights a key technical parameter: the optimal concentration of the polymeric flocculant composition. In both sandy and loamy soil environments, the formulation with the polymeric flocculant composition exhibited superior leaching inhibition compared to the formulation without any polymeric flocculant. This further confirms the effectiveness and necessity of the composition.

[0106] (III) Field efficacy experiments using the above-mentioned polymeric flocculant compositions of different concentrations and comparative proportions.

[0107] Experimental example:

[0108] Experimental crop: Shuofeng 52 cotton

[0109] Experimental Site: The experimental site was located at the Shihezi University Experimental Farm, Erlian Branch of Shihezi General Farm, Shihezi City, Xinjiang. This plot of land had been continuously planted with cotton for over 20 years and was divided into 10 experimental zones. Weed control experiments were conducted using reagents from Examples 10-14, Comparative Examples 5-9, and a blank control (without any herbicides). The soil in the experimental site was sandy, and the main weeds included broadleaf weeds such as black nightshade and amaranth, with an incidence rate of 55-70%.

[0110] Cultivation conditions: Drip irrigation under mulch is used, with 3 pipes per 6 rows per 10 mu (approximately 667 square meters), a plant spacing of 10 cm, and a row spacing of...

[0111] The cultivation pattern of 10cm+66cm+10cm+66cm+10cm was adopted, the field fertilizer and water management was standardized, the irrigation and drainage facilities were complete, and the experimental preparation was sprayed 2 days after sowing, with a spraying amount of 100ml / mu.

[0112] Weed survey methods:

[0113] Weed control was conducted using a random sampling method. Four quadrats were randomly selected from each experimental field, each 0.5m × 0.5m, for a total area of ​​1 square meter. Cotton emergence and weed species and quantity were assessed 20 days after application, 30 days later, and 45 days later, the control efficacy per plant was assessed. The fresh weight of the weed aboveground parts was also measured. Efficacy calculations were performed according to the Field Efficacy Test Guidelines for Pesticides (II) GB / T17980.128-2004.

[0114] Method for calculating prevention and control effectiveness:

[0115] Crop herbicide damage survey method: Control efficacy per plant (%) = (Number of weeds in the blank control area - Number of weeds in the treated area) / Number of weeds in the blank control area × 100%

[0116] Observe the cotton plants 20 and 30 days after application for any phytotoxicity, and record the type and severity of the phytotoxicity. Record as follows:

[0117] a) If the damage from pesticides can be counted or measured, express it in absolute terms, such as the number of plants or the height of the plants.

[0118] b) In other cases, the severity and frequency of phytotoxicity can be estimated using the following two methods:

[0119] 1) Assign a score to each plot of land based on the method for classifying pesticide damage:

[0120] Grade 1: The cotton is growing normally and shows no signs of damage;

[0121] Level 2: Slight pesticide damage to cotton, with damage less than 10%;

[0122] Level 3: Moderate pesticide damage to cotton, which can recover later and will not affect yield;

[0123] Level 4: Severe herbicide damage to cotton, difficult to recover from, resulting in reduced yield;

[0124] Level 5: Severe pesticide damage to cotton, irreversible, resulting in significant yield reduction or total crop failure.

[0125] 2) Compare the drug-treated area with the blank control area to evaluate the percentage of drug damage.

[0126] Accurately describe the symptoms of herbicide damage to cotton (growth inhibition, chlorosis, necrotic spots, deformity, etc.). Record the growth status of cotton under all conditions. Observe the interaction between herbicide damage and adverse factors. Specifically, the statistics of cotton emergence rate and weed control efficacy after herbicide application are shown in Table 5.

[0127] Table 5. Effects of pesticide application on cotton plant height and emergence rate.

[0128]

[0129] Note: The table uses Duncan's new multiple range method in SPSS software for one-way ANOVA. Lowercase letters indicate that the differences in data in the same column are significant (P<0.05), and uppercase letters indicate that the differences in data in the same column are extremely significant (P<0.01).

[0130] Analysis of the data in Table 5 shows that, under the condition of a spraying dosage of 100 ml / mu, the effects of each embodiment (including different concentrations of polymeric flocculant compositions) on crop emergence rate and plant height were not significantly different from the blank control. This indicates that at this dosage, the addition of polymeric flocculant will not have an adverse effect on crop growth, ensuring its safety for crop growth.

[0131] II. Experimental crop: Shuofeng 52 cotton

[0132] Experimental Site: The experimental site was located at the Shihezi University Experimental Farm, Erlian Branch of Shihezi General Farm, Shihezi City, Xinjiang. This plot of land had been continuously planted with cotton for over 20 years and was divided into 8 experimental zones. Weed control experiments were conducted using reagents from Examples 1-5, Comparative Examples 1-2, and a blank control (without any herbicides). The soil in the experimental site was sandy. The main weeds included broadleaf weeds such as black nightshade and amaranth retroflexus, with an incidence rate of 55-70%.

[0133] Cultivation conditions: Drip irrigation under mulch is used, with 3 pipes per 6 rows per 10 mu (approximately 667 square meters), a plant spacing of 10 cm, and a row spacing of...

[0134] The cultivation pattern of 10cm+66cm+10cm+66cm+10cm was adopted, the field fertilizer and water management was standardized, the irrigation and drainage facilities were complete, and the experimental preparation was sprayed 2 days after sowing, with a spraying amount of 400ml / mu.

[0135] Weed survey method: same as above

[0136] Table 6. Statistics on cotton seedling emergence and weed control efficacy after pesticide application.

[0137]

[0138] Note: The table uses Duncan's new multiple range method in SPSS software for one-way ANOVA. Lowercase letters indicate that the differences in data in the same column are significant (P<0.05), and uppercase letters indicate that the differences in data in the same column are extremely significant (P<0.01).

[0139] Table 7. Effects of pesticide application on cotton plant height.

[0140]

[0141]

[0142] Note: The table uses Duncan's new multiple range method in SPSS software for one-way ANOVA. Lowercase letters indicate that the differences in data in the same column are significant (P<0.05), and uppercase letters indicate that the differences in data in the same column are extremely significant (P<0.01).

[0143] An investigation of cotton emergence rate at 20 days revealed that the composition of this invention had virtually no effect on cotton emergence rate compared to the blank control. At a spraying rate of 100 ml / mu, there were no significant differences in plant height inhibition rate and emergence rate at 20, 30, and 45 days (see Table 5). At a spraying rate of 400 ml / mu, the composition showed stable weed control efficacy at 20, 30, and 45 days, significantly improving the control efficacy against broadleaf weed *Solanum nigrum*. Table 7 shows that the plant height inhibition rates at 20, 30, and 45 days were lower than the control and showed no significant difference from the blank control, demonstrating extremely high safety. Therefore, this composition has a significant effect on reducing herbicide damage in cotton fields, significantly inhibiting crop damage caused by downward leaching of the herbicide, improving the safety of the herbicide for crops, and achieving safe and efficient utilization of quinclorac.

[0144] The preferred embodiments of the present invention have been described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the scope of the technical concept of the present invention, various simple modifications can be made to the technical solution of the present invention, and these simple modifications all fall within the protection scope of the present invention.

[0145] Furthermore, various different embodiments of the present invention can be combined in any way, as long as they do not violate the spirit of the present invention, they should also be regarded as the content disclosed by the present invention.

Claims

1. A safe quinacrine formulation, characterized in that, The formulation contains active ingredients and adjuvants, including a polymeric flocculant, which accounts for 0.1-20% of the formulation mass; the active ingredient contains quinacrine.

2. The safe quinclorac formulation according to claim 1, characterized in that, The polymeric flocculant is one or more of the following: inorganic polymeric flocculant, organic polymeric flocculant, cationic organic polymeric flocculant, anionic organic polymeric flocculant, and nonionic organic polymeric flocculant.

3. The safe quinclorac formulation according to claim 2, characterized in that, The inorganic polymeric flocculants are: polyaluminum sulfate, polyaluminum chloride, polyferric sulfate, and polyferric chloride; the organic polymeric flocculants are: polyacrylamide, sulfonated polyvinylbenzene, and polyvinyl ether, one or more of the following; the cationic organic polymeric flocculants are: polyacrylamide and its derivatives, homopolymers of dimethyl diallyl ammonium chloride (DMDAAC) and copolymers with acrylamide (AM), copolymers of vinyltrimethoxysilane (VYMS) and (DMDAAC), and polyimide, one or more of the following; the anionic organic polymeric flocculants are: sodium polyacrylate, copolymers of acrylamide and sodium acrylate, and sodium polystyrene sulfonate, one or more of the following; and the nonionic organic polymeric flocculants are: nonionic polyacrylamide, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyvinyl methyl ether, and polyalkylphenol-ethylene oxide, one or more of the following.

4. The safe quinclorac formulation according to claim 3, characterized in that, The polymeric flocculant is polymeric flocculant A and / or polymeric flocculant B, wherein polymeric flocculant A is a polymeric flocculant with a molecular weight of 1,000,000 to 5,000,000; and polymeric flocculant B is a polymeric flocculant with a molecular weight of 35,000 to 150,000.

5. The safe quinacrine formulation according to claim 4, characterized in that, When the polymeric flocculant is polymeric flocculant A and polymeric flocculant B, the mass ratio of polymeric flocculant A to polymeric flocculant B is 1:0.1 to 10.

6. The safe quinclorac formulation according to claim 1, characterized in that, The additives are one or more of the following: emulsifiers, dispersants, wetting agents, spreading agents, stabilizers, defoamers, synergists, penetrants, adhesives, safety agents, carriers, and fillers.

7. The safe quinclorac formulation according to any one of claims 1-6, characterized in that, The formulation is a wettable powder, emulsifiable concentrate, soluble concentrate, aqueous solution, oil suspension, water suspension, water-dispersible granule, dry suspension, water emulsion, microemulsion, floating granule, effervescent agent, or large granule.

8. The safe quinacrine formulation according to claim 7, characterized in that, When the formulation is an emulsifiable concentrate, the polymeric flocculant accounts for 0.1-10% by weight of the formulation; When the formulation is an aqueous solution, the polymeric flocculant accounts for 0.1-5% by weight of the formulation; When the formulation is an aqueous suspension, the polymeric flocculant accounts for 0.1-1% of the formulation by weight.

9. The application of the safe quinclorac formulation according to claim 1, characterized in that, The application of the safe quinacrine formulation in the control of weeds in crop fields and in inhibiting quinacrine leaching.

10. The application of the safe quinclorac formulation according to claim 8, characterized in that, The crops mentioned are sorghum, wheat, corn, sugarcane, and cotton.

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