A herbal tea composition for conditioning abnormal bile quality and its preparation method and application

Abstract

The application discloses a health tea composition for regulating abnormal bile quality and a preparation method and application thereof, and belongs to the technical field of biotechnology. The health tea composition comprises the following raw materials in parts by weight: mulberry leaves 5-10 parts, chrysanthemum 4-8 parts, dried roxburgh rose 5-10 parts, emblic 4-8 parts, gardenia 1-3 parts and licorice 2-4 parts. The application is prepared according to the medical humoral theory, and is accurate for abnormal bile quality (dry heat) people, and is a health tea for regulating. The health tea has the functions of clearing heat and moisturizing, and is suitable for the people with dry mouth, dry throat, dry eyes, irritability and insomnia. The application provides a safe, convenient and effective health tea product for daily regulation of abnormal bile quality people.

Description

Technical Field

[0001] This invention relates to the field of biotechnology, and in particular to a tea substitute composition for regulating abnormal choleric constitution, its preparation method, and its application. Background Technology

[0002] Uyghur medicine is an important ethnic medical system in the Xinjiang Uyghur Autonomous Region, possessing a complete theoretical system and rich clinical practice. Uyghur medicine believes that the human body, under the influence of the four elements (fire, air, water, and earth) and the individual's temperament, uses various nutrients as raw materials and, through the normal function of the liver, produces four humors (Hilit): choleric, hemolytic, phlegmatic, and black bile. When these four humors maintain a certain balance in their quantity and quality, the human body is in a normal physiological state; conversely, once this balance is disrupted, disease will result.

[0003] Normal bile is located in the gallbladder, is yellow in color, bitter in taste, and has a strong, hot nature, corresponding to "fire." It has functions such as warming the body, breaking down fat, aiding digestion, enhancing intestinal peristalsis, promoting defecation, and detoxification. When bile undergoes abnormal changes in quantity or quality due to internal or external factors, abnormal bile is formed, manifesting as excessive heat and dryness, with symptoms such as burning pain in the affected area, dry mouth and throat, insomnia, and a thin, tight pulse. It is closely related to various inflammations and nervous system diseases. The principles of regulating abnormal bile in Uyghur medicine are: clearing the liver and gallbladder to counteract heat and dryness, nourishing yin and moistening dryness to restore body fluids, and calming the mind and soothing the nerves to stabilize the spirit.

[0004] Mulberry leaves are from the plant *Morus alba* (Moraceae family). White mulberry Mulberry leaves (L.) are a traditional food and medicine homology substance. The *Pharmacopoeia of the People's Republic of China* records that they are sweet and bitter in taste, cold in nature, and enter the lung and liver meridians, functioning to disperse wind-heat, clear the lungs and moisten dryness, and clear the liver and improve eyesight. The first volume of the ancient Uyghur medical text *Classic Uyghur Medicine* records that boiling mulberry leaves can relieve toothache and quench thirst, confirming the historical origin of mulberry leaves as a traditional Uyghur medicinal material. The liver-clearing and dryness-moistening effects of mulberry leaves highly correspond to the core pathogenesis of abnormal choleric constitution; however, due to their cold nature, long-term use alone may damage the spleen and stomach.

[0005] Currently, numerous mulberry leaf-based herbal tea products are available on the market, such as mulberry leaf and chrysanthemum tea and mulberry leaf and cassia seed tea. However, these products are mostly designed under the guidance of traditional Chinese medicine theory. Existing patent literature includes health teas combining mulberry leaves with figs and goji berries, beverages combining mulberry leaves with chrysanthemums and amla, and compound products using various medicinal and edible ingredients such as mulberry leaves, dendrobium officinale, goji berries, and Solomon's seal. However, these existing technologies have the following shortcomings: First, none of them are based on the Uyghur medical theory of body fluids in their formulation design, making it impossible to precisely regulate abnormal choleric constitutions. Their heat-clearing, yin-nourishing, and calming effects lack organic synergy guided by Uyghur medical theory. Second, some formulas use figs and goji berries, which are either too rich or too sweet and warm in nature. In the context of clearing dry heat, this may lead to "stomach irritation" or "dampness and heat generation," which is not conducive to long-term conditioning of dry-heat constitutions. How to achieve the effects of clearing away dryness and heat while simultaneously nourishing yin, moisturizing dryness, calming the mind, and soothing the nerves, while maintaining the compatibility characteristics of "clearing while moisturizing, cooling without stagnation," and forming an innovative formula that is both different from existing TCM constitution conditioning products and in line with the theoretical logic of Uyghur medicine, is a technical problem that has not yet been solved in this field. Summary of the Invention

[0006] The purpose of this invention is to provide a substitute tea composition for regulating abnormal choleric constitution, its preparation method, and its application, thereby solving the problems existing in the prior art. Guided by the humoral theory of Uyghur medicine, this invention precisely targets individuals with abnormal choleric (dry-heat) constitution, preparing a conditioning substitute tea. This substitute tea formula combines heat-clearing and moisturizing properties, balancing tonification and purging without harming the stomach and intestines, and is especially suitable for those with abnormal choleric dry-heat syndrome exhibiting symptoms such as dry mouth and throat, dry eyes, irritability, and insomnia.

[0007] To achieve the above objectives, the present invention provides the following solution: This invention provides a tea substitute composition for regulating abnormal choleric constitution, wherein the tea substitute composition comprises the following raw materials in parts by weight: 5-10 parts mulberry leaves, 4-8 parts chrysanthemum, 5-10 parts dried prickly pear, 4-8 parts amla, 1-3 parts gardenia, and 2-4 parts licorice.

[0008] Optionally, the substitute tea composition comprises, by weight, the following raw materials: 7 parts mulberry leaves, 6 parts chrysanthemum, 7 parts dried prickly pear, 6 parts amla, 2 parts gardenia, and 3 parts licorice.

[0009] Optionally, the substitute tea composition comprises, by weight, the following raw materials: 5 parts mulberry leaves, 4 parts chrysanthemum, 10 parts dried prickly pear, 8 parts amla, 1 part gardenia, and 4 parts licorice.

[0010] Optionally, the substitute tea composition comprises, by weight, the following raw materials: 10 parts mulberry leaves, 8 parts chrysanthemum, 5 parts dried prickly pear, 4 parts amla, 3 parts gardenia, and 2 parts licorice.

[0011] The present invention also provides a method for preparing the above-mentioned substitute tea composition, comprising the following steps: (1) Chop the dried prickly pear and amla into coarse particles with a particle size of 0.3-0.8 cm; (2) Mix dried prickly pear and coarse granules of amla with mulberry leaves, chrysanthemum, gardenia and licorice evenly, pulverize and pass through a 10-40 mesh sieve, and package in 6-10g bags.

[0012] The present invention also provides the use of the above-mentioned substitute tea composition in the preparation of products for conditioning abnormal choleric constitution.

[0013] The present invention also provides a product for regulating abnormal bile constitution, the product comprising the above-mentioned substitute tea composition.

[0014] The present invention discloses the following technical effects: This invention provides a tea substitute composition for regulating abnormal choleric constitution, prepared from mulberry leaves, chrysanthemum, dried prickly pear, amla, gardenia, and licorice. Mulberry leaves, which clear the liver, moisten dryness, and disperse wind-heat, are the principal ingredient; chrysanthemum, which clears the liver, improves eyesight, and disperses wind-heat, is the assistant ingredient; the two ingredients work together to clear liver and gallbladder fire. Prickly pear, sweet, sour, and cool in nature, clears heat, generates fluids, strengthens the stomach, and aids digestion; it can assist in treating summer heat damaging body fluids, irritability, and thirst, and is the adjuvant ingredient. Amla, sweet, sour, and astringent in nature, is cool and enters the lung and stomach meridians; it clears heat, cools the blood, aids digestion, strengthens the stomach, generates fluids, and relieves cough, and is the adjuvant ingredient. The combination of these two ingredients enhances the effects of generating fluids, quenching thirst, protecting the middle jiao (spleen and stomach), and preventing injury, while avoiding the accumulation of heat and pathogens, achieving a "clearing yet moistening, cooling without stagnation" effect. Gardenia, which clears heat, relieves irritability, and guides stagnant heat downwards, is the guiding ingredient; licorice harmonizes the other ingredients and moderates the bitterness and coldness of gardenia. This formula combines heat-clearing and moisturizing properties, balancing tonification and purging without harming the stomach and intestines. It is especially suitable for those with abnormal bile-type dry heat syndrome who experience symptoms such as dry mouth and throat, dry eyes, irritability, and insomnia.

[0015] Compared with existing technologies, this invention is the first to be guided by the Uyghur medical theory of body fluids, precisely targeting individuals with abnormal choleric (dry-heat) constitution. Based on the Uyghur medical understanding of the pathogenesis of "dry-heat damaging body fluids" in abnormal choleric constitution, the raw materials are specifically selected. The tea substitute composition of this invention employs a synergistic formula of "heat-clearing herbs + Uyghur-specific dried fruits," replacing commonly used figs and goji berries in existing technologies with a combination of dried prickly pear and amla, and incorporating mulberry leaves, chrysanthemum, gardenia, and licorice, thus avoiding the side effects of promoting dampness and causing bloating. This invention's tea substitute has a clear Uyghur medical indication—abnormal choleric (dry-heat) constitution and its common accompanying symptoms (dry mouth and throat, insomnia, dry eyes, poor appetite, abdominal distension, etc.), facilitating precise selection in Uyghur clinical practice. Furthermore, all raw materials are listed in the food and medicine homology catalogue or are common food raw materials containing dried fruits, containing no prohibited substances. Comparative experiments show good safety, making it suitable for long-term conditioning use, ensuring the product's safety, compliance, and accessibility, providing reliable assurance for consumers' daily tea substitute consumption. Detailed Implementation

[0016] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as a limitation of the present invention, but rather as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0017] It should be understood that the terminology used in this invention is merely for describing particular embodiments and is not intended to limit the invention. Furthermore, with respect to numerical ranges in this invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Any stated value or intermediate value within a stated range, as well as each smaller range between any other stated value or intermediate value within said range, is also included within the scope of this invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0018] Unless otherwise stated, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. While only preferred methods and materials have been described herein, any methods and materials similar or equivalent to those described herein may be used in the implementation or testing of this invention. All references to this specification are incorporated by way of citation to disclose and describe methods and / or materials associated with those references. In the event of any conflict with any incorporated reference, the content of this specification shall prevail.

[0019] Various modifications and variations can be made to the specific embodiments described in this specification without departing from the scope or spirit of the invention, as will be apparent to those skilled in the art. Other embodiments derived from this specification will also be readily apparent to those skilled in the art. This specification and embodiments are merely exemplary.

[0020] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0021] All medicinal materials used in the following examples were purchased from Chinese medicinal herb processing enterprises that comply with the Good Manufacturing Practice (GMP) for pharmaceuticals, and dried fruit raw materials were purchased from Xinjiang Uygur Autonomous Region and Guizhou production areas.

[0022] The key raw materials used in the following examples are described below: Dried prickly pear: This product is made from the dried, ripe fruit of *Rosa roxburghii* Tratt., a plant in the Rosaceae family, which is sliced ​​and dried. Prickly pear fruit is sweet, sour, and cool in nature, and has the effects of strengthening the stomach and aiding digestion, clearing heat and promoting body fluid production. It is recorded in the "Quality Standards for Traditional Chinese Medicine and Ethnic Medicines of Guizhou Province". This product can be used as a common food ingredient in the production of substitute tea within the relevant announcements of the State Administration for Market Regulation and the National Health Commission. In this application, it is added as an excipient in the form of fruit slices (dried prickly pear), and the medicinal use of the raw material itself is not claimed.

[0023] Phyllanthus emblica L., a plant of the Euphorbiaceae family, is the dried, mature fruit of Phyllanthus emblica L. It is listed in Part I of the Pharmacopoeia of the People's Republic of China. It has a sweet, sour, and astringent taste, and is cool in nature. It enters the lung and stomach meridians and functions to clear heat and cool the blood, promote digestion and strengthen the stomach, and promote the production of body fluids and relieve cough. It belongs to the category of food and medicine homology.

[0024] The compatibility principle of this invention is as follows: Mulberry leaves clear the liver and moisten dryness, dispel wind and heat, directly addressing the core pathogenesis of abnormal bile-induced dryness and heat, making them the principal herb; chrysanthemum clears the liver and improves eyesight, dispels wind and heat, making them the assistant herb. The two herbs work together to clear liver and gallbladder fire.

[0025] The key innovation of this formula lies in replacing commonly used fruits such as figs and goji berries with dried prickly pear and amla in existing technologies. Prickly pear (Rosa roxburghii Tratt.), the fruit of a plant in the Rosaceae family, is widely used in folk remedies in Guizhou and Yunnan provinces. It is sweet, sour, and cool in nature, and functions to clear heat, generate fluids, strengthen the stomach, and aid digestion. It can assist in the treatment of summer heat damaging body fluids, irritability, and thirst. Its heat-clearing and fluid-generating effects correspond precisely to the pathogenesis of "dry heat damaging body fluids" in abnormal choleric constitution. The Pharmacopoeia of the People's Republic of China records amla (Phyllanthus emblica L.), also known as Amla, as a commonly used Tibetan medicine and a food-medicine homology substance. It is sweet, sour, and astringent in taste, cool in nature, and enters the lung and stomach meridians. Its functions include clearing heat and cooling blood, aiding digestion and strengthening the stomach, generating fluids, and relieving cough. In Uyghur medicine, amla is called "Amila" and has a long history of use as a traditional Uyghur medicine, known for its heat-clearing, blood-nourishing, and dryness-moistening effects. This invention utilizes a synergistic combination of dried prickly pear and amla, a targeted technical choice based on an in-depth analysis of the pathogenesis of abnormal choleric temperament. Abnormal choleric temperament presents with excessive heat and dryness, requiring both the clearing of liver and gallbladder fire and the protection of already depleted body fluids, avoiding the use of bitter and drying heat-clearing herbs that could damage yin. While dried figs can moisten the lungs and protect the middle jiao, their heat-clearing power is somewhat insufficient; wolfberries nourish yin and blood, but their sweet and warm nature carries the risk of promoting dampness. Dried prickly pear, however, possesses both heat-clearing and fluid-generating properties, as well as stomach-strengthening and digestive benefits. Amla clears heat, cools the blood, generates fluids, and moistens dryness. The combination of these two herbs enhances the effects of generating fluids and quenching thirst, protecting the middle jiao and preventing damage, while avoiding the accumulation of heat and pathogenic factors. This achieves a "clearing yet moistening, cooling without stagnation" synergistic effect, a technical advantage that cannot be anticipated by existing "fig + wolfberry" combinations.

[0026] In addition, gardenia clears heat and relieves irritability, and guides stagnant heat downwards as the guiding herb; licorice harmonizes the other herbs and also moderates the bitter and cold nature of gardenia. The entire formula clears heat while also moisturizing, combining purging and tonifying without harming the stomach and intestines, and is especially suitable for those with abnormal cholestatic dry heat syndrome who experience dry mouth and throat, dry eyes, irritability, and insomnia.

[0027] Example 1 This embodiment provides a tea substitute composition for regulating abnormal choleric constitution, the formula of which is: 7g mulberry leaves, 6g chrysanthemum, 7g dried prickly pear, 6g amla, 2g gardenia and 3g licorice.

[0028] Its preparation method is as follows: First, finely chop dried prickly pear and amla (Phyllanthus parasiticus) into coarse particles with a diameter of 0.3-0.8 cm. Mix the coarse dried fruit particles evenly with the remaining raw materials, grind them into powder using a grinder, and pass the powder through a 20-mesh sieve. Package the resulting mixed powder into 8 g portions in food-grade heat-sealable filter bags and store them in an airtight container.

[0029] Usage: To brew, take one packet and steep in 300-400 mL of boiling water for 5 minutes before drinking. It can be brewed repeatedly 2-3 times. 1-3 doses daily.

[0030] Example 2 This embodiment provides a tea substitute composition for regulating abnormal choleric constitution, the formula of which is: 5g mulberry leaves, 4g chrysanthemum, 10g dried prickly pear, 8g amla, 1g gardenia and 4g licorice.

[0031] The preparation method is the same as in Example 1, and the packaging specification is 6g per bag.

[0032] Example 3 This embodiment provides a tea substitute composition for regulating abnormal choleric constitution, the formula of which is: 10g mulberry leaves, 8g chrysanthemum, 5g dried prickly pear, 4g amla, 3g gardenia and 2g licorice.

[0033] The preparation method is the same as in Example 1, and the packaging specification is 10g per bag.

[0034] Comparative Example 1 This comparative example provides a tea substitute composition for regulating abnormal choleric constitution, the formula of which is: 7g mulberry leaves, 6g chrysanthemum, 8g dried figs, 6g wolfberries, 2g gardenia, and 3g licorice.

[0035] The preparation method is the same as in Example 1, and the packaging specification is 8g per bag.

[0036] Comparative Example 2 This comparative example provides a tea substitute composition for regulating abnormal choleric constitution, the formula of which is: 7g mulberry leaf, 6g chrysanthemum, 2g gardenia, and 3g licorice.

[0037] The preparation method is the same as in Example 1, and the packaging specification is 8g per bag.

[0038] Experimental Example 1 Sixty volunteers were selected who were diagnosed with abnormal choleric temperament (dry heat) according to Uyghur medicine and complained of dry mouth and throat, dry eyes, and irritability. The inclusion criteria were: (1) age 18-70 years old; (2) diagnosed with abnormal choleric temperament according to Uyghur medicine and complaining of dry mouth and throat, dry eyes, and irritability; (3) willing to participate in this study and sign the informed consent form; (4) able to drink the substitute tea regularly as required by the study protocol and cooperate with the follow-up assessment. The exclusion criteria were: (1) those with severe heart, liver, or kidney dysfunction; (2) pregnant or lactating women; (3) those allergic to any of the ingredients in this product; (4) those who have taken other Uyghur medicine abnormal choleric temperament-related preparations within the past month; and (5) those who could not cooperate with the study protocol to complete the observation.

[0039] Volunteers were randomly divided into three groups. Group 1 received the herbal tea of ​​Example 1, Group 2 received the herbal tea of ​​Comparative Example 1, and Group 3 received the herbal tea of ​​Comparative Example 2. Each group received one dose daily for 14 consecutive days. After 14 days, the visual analog scale (VAS, 0-10, higher scores indicate more severe symptoms) for dry mouth and throat and the effectiveness rate of improvement in irritability and insomnia were used as evaluation indicators. The results are shown in Table 1. It can be seen that the VAS score for dry mouth in Group 1 decreased from 7.32±1.15 before drinking to 2.18±0.73, in Group 2 from 7.28±1.20 to 3.45±0.89, and in Group 3 from 7.35±1.12 to 4.10±1.04; the effectiveness rate of improvement in irritability and insomnia was 85% in Group 1, 65% in Group 2, and 50% in Group 3. Furthermore, during the drinking period, 3 patients in Group 2 complained of abdominal distension and discomfort, while no similar feedback was reported in Groups 1 and 3. The results showed that replacing figs and wolfberries with a combination of dried prickly pear and amla resulted in significantly better improvement of abnormal bile-type symptoms such as dry mouth and throat, irritability and insomnia, with better spleen and stomach tolerance, achieving unexpected technical effects.

[0040] Table 1. Test Results The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A tea substitute composition for regulating abnormal choleric constitution, characterized in that, The substitute tea composition comprises the following raw materials in parts by weight: 5-10 parts mulberry leaves, 4-8 parts chrysanthemum, 5-10 parts dried prickly pear, 4-8 parts amla, 1-3 parts gardenia, and 2-4 parts licorice.

2. The tea substitute composition according to claim 1, characterized in that, The substitute tea composition comprises the following raw materials in parts by weight: 7 parts mulberry leaves, 6 parts chrysanthemum, 7 parts dried prickly pear, 6 parts amla, 2 parts gardenia, and 3 parts licorice.

3. The tea substitute composition according to claim 1, characterized in that, The substitute tea composition comprises the following raw materials in parts by weight: 5 parts mulberry leaves, 4 parts chrysanthemum, 10 parts dried prickly pear, 8 parts amla, 1 part gardenia, and 4 parts licorice.

4. The tea substitute composition according to claim 1, characterized in that, The substitute tea composition comprises the following raw materials in parts by weight: 10 parts mulberry leaves, 8 parts chrysanthemum, 5 parts dried prickly pear, 4 parts amla, 3 parts gardenia, and 2 parts licorice.

5. A method for preparing the tea substitute composition according to any one of claims 1-4, characterized in that, Includes the following steps: (1) Chop the dried prickly pear and amla into coarse particles with a particle size of 0.3-0.8 cm; (2) Mix dried prickly pear and coarse granules of amla with mulberry leaves, chrysanthemum, gardenia and licorice evenly, pulverize and pass through a 10-40 mesh sieve, and package in 6-10g bags.

6. The use of the tea substitute composition according to any one of claims 1-4 in the preparation of a product for conditioning abnormal choleric constitution.

7. A product for regulating abnormal choleric constitution, characterized in that, The product contains the tea substitute composition according to any one of claims 1-4.

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