Deep vein thrombosis monitoring and warning method and related devices

Abstract

The present application belongs to the field of medical monitoring and computer technology, and provides a deep vein thrombosis monitoring and early warning method and related equipment, comprising: obtaining a corrected exercise safety level and an individualized effective exercise dose target interval according to the superposition of specific parameters and a motion safety evaluation baseline scale; generating a non-weight-bearing body position driving exercise program to guide the patient to sequentially perform the exercise cycle of lifting, maintaining and lowering the affected limb; real-time acquisition of motion signals and conversion into gravity potential energy change, thereby determining the actual effective exercise dose; synchronous acquisition of foot bottom partition pressure, bilateral limb isochronous temperature and photoelectric plethysmogram perfusion parameters as safety constraint conditions; when the actual effective exercise dose is within the target interval and the safety constraint conditions do not exceed the boundary, the current exercise program is maintained; otherwise, the exercise parameters are automatically adjusted or switched to intermittent air pressure assistance, and the present application realizes exercise quantification and safety risk grading early warning of diabetic foot patients during rehabilitation.

Description

Technical Field

[0001] This invention relates to the fields of medical monitoring and computer technology, and in particular to a method and related equipment for monitoring and early warning of deep vein thrombosis. Background Technology

[0002] Patients with diabetic foot need to perform rehabilitation training or exercises to promote venous return in the lower limbs during their daily rehabilitation process to avoid deep vein thrombosis. However, due to neuropathy, patients with diabetic foot cannot perceive abnormal signals such as pain and swelling in the affected limb. Therefore, the amount of exercise when performing rehabilitation exercises on their own or with the use of external physical assistive devices lacks quantitative standards and real-time feedback mechanisms, making it impossible to effectively control the amount of exercise and leading to the risk of deterioration. Summary of the Invention

[0003] In order to at least solve one of the technical problems existing in the prior art, the present invention provides a method and related equipment for monitoring and early warning of deep vein thrombosis.

[0004] One aspect of the present invention provides a method for monitoring and early warning of deep vein thrombosis, comprising: Specific parameters of the target patients were obtained and superimposed on the baseline scale for exercise safety assessment to obtain the corrected exercise safety level and individualized effective exercise dose target range. The specific parameters included Wagner grade of foot ulcer, ulcer area, ankle-brachial index (ABI), peripheral neuropathy score and blood glucose fluctuation level. A non-weight-bearing postural drive exercise program is generated, which is used to guide the target patient to perform the exercise cycle of raising, holding and lowering the affected limb in sequence; Motion signals are acquired in real time and converted into changes in gravitational potential energy. The actual effective motion dose is determined based on the accumulated changes in gravitational potential energy. The motion signals include the phase and amplitude of the motion cycle. Simultaneously collect plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters of the target patient when performing non-weight-bearing posture-driven exercise. The obtained plantar pressure peak, wound side temperature change rate, and perfusion index relative to baseline are used as safety constraints. When the actual effective exercise dose is within the target range and the safety constraints are not exceeded, the non-weight-bearing body position driven exercise program is maintained; otherwise, the exercise parameters are automatically adjusted or the intermittent pneumatic assist is switched. Exercise safety risk classification and early warning are based on the wound side temperature change rate, perfusion index ratio relative to baseline, and actual effective exercise dose.

[0005] According to the aforementioned deep vein thrombosis monitoring and early warning method, the correction methods for the individualized effective exercise dose target range include: Based on the dose range of the baseline exercise safety level, the upper limit of the dose is adjusted downward and the dose range is narrowed according to at least one of the following: increased Wagner grade, increased ulcer area, decreased ABI, increased peripheral neuropathy score, and increased blood glucose fluctuation level; for Charcot foot without active ulcers or high-risk contralateral limbs, the lower limit of the dose is adjusted upward.

[0006] According to the aforementioned deep vein thrombosis monitoring and early warning method, the calculation method for the change in gravitational potential energy includes: Based on the length of the affected limb With the amplitude of the inclination angle within the period according to Calculate the change in potential energy over a single period, where This is an estimate of the limb's mass. For gravitational acceleration, only periods where both amplitude and duration reach the preset effective threshold are included in the cumulative calculation.

[0007] According to the aforementioned deep vein thrombosis monitoring and early warning method, the safety constraints include: The peak pressure of the plantar region is not greater than the preset plantar safety threshold; the increase in temperature at the same site on the wound side relative to the pre-exercise baseline is not greater than the preset temperature safety threshold; the perfusion index is not lower than a preset multiple of the baseline value; the plantar safety threshold is set according to the Wagner classification and the ulcer site.

[0008] According to the aforementioned deep vein thrombosis monitoring and early warning method, the automatic adjustment of motion parameters includes: The elevation range and movement frequency are reduced to the preset safe level; Suspend active elevation exercises and switch to passive reflux promotion driven by intermittent pneumatic compression device, and apply lower compression pressure or no pressure to the limb with ulcers than the contralateral limb. It also includes stopping the movement and issuing a safety warning.

[0009] According to the aforementioned deep vein thrombosis monitoring and early warning method, the method further includes: The specific parameters of the target patient are periodically acquired, and the individualized effective exercise dose target range is dynamically adjusted according to the degree of parameter change.

[0010] According to the aforementioned deep vein thrombosis monitoring and early warning method, the method further includes: The target patients are calibrated, including using the changes in venous return velocity measured by Doppler ultrasound or 4D Flow magnetic resonance as a reference, and the mapping relationship between the change in gravitational potential energy and the effective exercise dose is individually calibrated and updated periodically.

[0011] Another aspect of the present invention provides a deep vein thrombosis monitoring and early warning device, comprising: Sensing module, data processing module, early warning module, air pressure-assisted module, and motion guidance module; The data processing module is connected to the sensing module, the early warning module, the motion guidance module, and the pneumatic assist module, respectively; the pneumatic assist module is installed on the affected limb of the target patient; The sensing module is used to collect motion data of the target patient, including motion signals, plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters. The data processing module is used to generate guidance instructions, sports safety risk classification warnings, and adjustment instructions based on the motion data. The motion guidance module is used to generate a non-weight-bearing posture-driven motion plan according to the guidance instructions; the early warning module performs early warning processing according to the motion safety risk classification; the pneumatic assist module is used to intermittently inflate and pressurize the affected limb according to the adjustment instructions.

[0012] According to the deep vein thrombosis monitoring and early warning device, the pneumatic assist module adopts an intermittent pneumatic pressurization device with independently set pressure on both sides, which is used to apply a lower pressure or no pressure to the limb with ulcers on the other side.

[0013] Another aspect of the present invention provides an electronic device, including a processor and a memory; The memory is used to store programs; The processor executes the program to implement the method as described above.

[0014] The beneficial effects of this invention are as follows: It uses non-weight-bearing posture-driven potential energy to convert kinetic energy into movement as the core intervention method; it identifies the limb elevation-holding-lowering movement cycle through tilt and acceleration sensors, geometrically calculates the change in gravitational potential energy, and accumulates it as the effective exercise dose; it combines diabetic foot-specific parameters (Wagner classification, ulcer area, ankle-brachial index, peripheral neuropathy score, and blood glucose fluctuation level) to individually correct the thrombosis risk assessment baseline and the target range of the effective exercise dose; under multiple safety constraints such as plantar pressure peak, wound temperature change rate, and perfusion index, it dynamically solves the dual-target safe movement window of thrombosis prevention and plantar protection, and monitors in real time during movement, automatically downgrading to a pneumatic-assisted passive mode when constraints exceed the limits, thus achieving closed-loop movement control and risk warning for the patient's foot movement. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the deep vein thrombosis monitoring and early warning method according to an embodiment of the present invention.

[0016] Figure 2 This is a schematic diagram of the non-weight-bearing body position driven motion cycle according to an embodiment of the present invention.

[0017] Figure 3 This is a schematic diagram illustrating the quantification of potential energy changes according to an embodiment of the present invention.

[0018] Figure 4 This is a schematic diagram of the dual-target safe movement window for preventing thrombosis and protecting the sole of the foot, according to an embodiment of the present invention.

[0019] Figure 5 This is a flowchart of the wound-thrombosis linkage monitoring and multi-level degradation strategy according to an embodiment of the present invention.

[0020] Figure 6 This is a schematic diagram of a deep vein thrombosis monitoring and early warning device according to an embodiment of the present invention. Detailed Implementation

[0021] The embodiments of the present invention are described in detail below, examples of which are shown in the accompanying drawings. Throughout the description, the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions. In the following description, suffixes such as "module," "part," or "unit" used to denote elements are used only for the purpose of illustrative purposes and have no specific meaning in themselves. Therefore, "module," "part," or "unit" can be used interchangeably. Terms such as "first," "second," etc., are used only to distinguish technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the sequential relationship of the indicated technical features. In the following description, the consecutive reference numerals for method steps are for ease of review and understanding. Adjusting the implementation order of steps, in conjunction with the overall technical solution of the present invention and the logical relationship between the various steps, will not affect the technical effect achieved by the technical solution of the present invention. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and should not be construed as limiting the present invention.

[0022] refer to Figure 1 , Figure 1 This is a schematic flowchart of a deep vein thrombosis monitoring and early warning method according to an embodiment of the present invention, which includes, but is not limited to, steps S100-S600: S100: Obtain specific parameters of the target patient, and overlay the specific parameters with the baseline scale for exercise safety assessment to obtain the corrected exercise safety level and the individualized effective exercise dose target range. The specific parameters include Wagner grade of foot ulcer, ulcer area, ankle-brachial index (ABI), peripheral neuropathy score, and blood glucose fluctuation level.

[0023] In some embodiments, the upper limit of the dose is adjusted downward and the dose range is narrowed based on the dose range of the baseline exercise safety level, according to at least one of the following: increased Wagner grade, increased ulcer area, decreased ABI, increased peripheral neuropathy score, and increased blood glucose fluctuation level; for Charcot foot without active ulcers or high-risk contralateral limbs, the lower limit of the dose is adjusted upward.

[0024] For example, for a patient with Wagner grade 2 foot ulcer, ABI=0.7, severe peripheral neuropathy score, and large blood glucose fluctuations: the baseline dose range obtained from the thrombosis risk baseline scale is [300, 500] J / day. The upper limit is lowered by 20% based on Wagner grade and ulcer area, and the range is narrowed to [300, 360] J / day based on severe neuropathy. Simultaneously, because ABI=0.7 is lower than 0.8 and blood glucose fluctuations are elevated, this narrowed range is maintained, and the upper limit of the single exercise retention period is further lowered. The plantar pressure safety threshold is lowered from 200 kPa in the general population to 150 kPa, and pressure is avoided on the wound side. The lower limit of the dose for the contralateral high-risk limb (without ulcer) is increased by 10%, achieving differentiated prescriptions for both lower limbs.

[0025] S200 generates a non-weight-bearing postural drive exercise program, which guides the target patient to perform the exercise cycle of raising, holding and lowering the affected limb in sequence.

[0026] The S300 acquires motion signals in real time and converts them into changes in gravitational potential energy. Based on the accumulated changes in gravitational potential energy, it determines the actual effective motion dose. The motion signal includes the phase and amplitude of the motion cycle.

[0027] In some embodiments, based on the length of the affected limb With the amplitude of the inclination angle within the period according to Calculate the change in potential energy over a single period, where This is an estimate of the limb's mass. For gravitational acceleration, only periods where both amplitude and duration reach the preset effective threshold are included in the cumulative calculation.

[0028] For example, refer to Figure 2 The diagram shown illustrates the non-weight-bearing posture-driven movement cycle, representing the elevation-hold-depression phase; Reference Figure 3 The diagram shown is a quantification diagram of energy change, used to illustrate... and The geometric relationship between them is used to calculate the change in gravitational potential energy per cycle, based on the length L of the affected limb (e.g., 0.65m) and the range of change in inclination angle within the cycle, θmax (e.g., 35°). Based on an estimated limb weight of m=10kg, ≈10×9.8×0.65×sin35°≈36.5J, only cycles with an amplitude of not less than 15° and a holding period of not less than 2 seconds are counted as effective cycles; the daily effective exercise dose ED=ΣΔPE, the 4D Flow experiment showed that the peak venous return velocity during the elevation-depression cycle was significantly increased, verifying the rationality of using the change in potential energy as a quantitative indicator of the venous return promotion effect.

[0029] The S400 simultaneously collects plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters of the target patient when performing a non-weight-bearing position-driven exercise program. The obtained plantar pressure peak, wound-side temperature change rate, and perfusion index relative to baseline are used as safety constraints.

[0030] In some embodiments, safety constraints include: the peak pressure of the plantar tract is not greater than a preset plantar safety threshold; the increase in temperature at the same site on the wound side relative to the pre-exercise baseline is not greater than a preset temperature safety threshold; the perfusion index is not lower than a preset multiple of the baseline value; and the plantar safety threshold is set according to the Wagner classification and the ulcer site.

[0031] For example, refer to Figure 4 The diagram illustrates a dual-target safe movement window for thrombosis prevention and foot preservation. It uses the effective exercise dose (ED) as the thrombosis prevention target axis and the peak plantar pressure and wound temperature change rate as the wound safety constraint axis. The safe movement window, formed by the intersection of these two axes, is calculated: the upper boundary of the window is determined by the wound safety constraint, and the lower boundary is determined by the thrombosis prevention dose requirement. When the patient's current ED is below the lower boundary of the window, the frequency of exercise guidance is increased; when it approaches or exceeds the upper boundary of the window, the amplitude and frequency are reduced; when the window disappears (constraints no longer intersect), a degraded strategy is directly implemented.

[0032] S500 maintains the non-weight-bearing posture-driven exercise program when the actual effective exercise dose is within the target range and the safety constraints are not exceeded; otherwise, it automatically adjusts the exercise parameters or switches to intermittent pneumatic-assisted exercise.

[0033] In some embodiments, automatically adjusting the motion parameters or switching to intermittent pneumatic assisted movement includes reducing the elevation amplitude and motion frequency to a preset safe level; pausing active elevation motion and switching to passive reflux promotion driven by an intermittent pneumatic pressurization device, and applying lower pressure or no pressure to the limb with ulcers than the contralateral limb; and also includes stopping the motion and outputting a safety warning.

[0034] In some embodiments, reference Figure 5The flowchart shown illustrates the wound-thrombosis linkage monitoring and multi-level degrading strategy. During exercise, the wound-side temperature is monitored in real time. If the wound-side temperature rises by more than 1.5°C from the pre-exercise baseline, or the perfusion index drops below 80% of the baseline, or the plantar pressure peak exceeds the individualized safety threshold, degrading is triggered: Level 1 reduces the elevation angle from 35° to 20° and halves the frequency; Level 2 suspends active exercise, switches to pneumatic-assisted movement mode, and sets the wound-side pressure to 50% of the contralateral side or eliminates pressure; Level 3 stops intervention and outputs a medical request prompt. If the wound healing trend is good (ulcer area shrinks), the target range is gradually increased following the reverse process of Example 3.

[0035] In some embodiments, a sensory impairment compensation warning is also included, as subjective pain and swelling symptoms are not reliable for patients with peripheral neuropathy. The system uses the temperature difference (TAI) at the same location on both lower legs as the core warning indicator: when the TAI exceeds 2.2°C and is accompanied by a difference in perfusion index and a daily increase in the circumference of the affected limb exceeding a set threshold, a medium-to-high risk warning is issued and an ultrasound examination is recommended, regardless of whether the patient has subjective symptoms; when the TAI is between 1.5°C and 2.2°C, a low-risk warning is issued and the lower limit of the exercise dose for the next day is increased.

[0036] In some embodiments, individualized calibration and validation are also included, such as measuring the change in peak femoral vein flow velocity before and after the elevation-lowering cycle using Doppler ultrasound at baseline upon admission, or performing 4D magnetic resonance imaging (MRI) flow scans on patients who are willing to cooperate, to establish individualized calibration and validation. - A backflow rate mapping table is used to correct the target dose range; thereafter, the mapping table is reviewed weekly using PPG perfusion trends and circumferential changes. The system can also utilize multimodal data accumulated during hospitalization to train individualized prediction models, enabling continued home-based prevention and control monitoring after discharge.

[0037] S600 performs exercise safety risk classification and early warning based on the wound side temperature change rate, the ratio of perfusion index to baseline, and the actual effective exercise dose.

[0038] In some embodiments, the sports safety risk classification and early warning can be provided through software such as an APP, or by using audible and visual alarms.

[0039] In some embodiments, reference Figure 6The schematic diagram of the deep vein thrombosis monitoring and early warning device shown includes a sensing module 10, a data processing module 20, an early warning module 40, a pneumatic assist module 50, and a motion guidance module 30. The data processing module 20 is connected to the sensing module 10, the early warning module 40, the motion guidance module 30, and the pneumatic assist module 50. The pneumatic assist module 50 is placed on the affected limb of the target patient. The sensing module 10 is used to collect the motion data of the target patient, including motion signals, plantar pressure, bilateral limb temperature at the same location, and photoplethysmography perfusion parameters. The data processing module 20 is used to generate guidance instructions, motion safety risk classification early warnings, and adjustment instructions based on the motion data. The motion guidance module 30 is used to generate a non-weight-bearing posture-driven exercise plan based on the guidance instructions. The early warning module 40 executes early warning processing based on the motion safety risk classification early warning. The pneumatic assist module 50 is used to intermittently inflate and pressurize the affected limb according to the adjustment instructions.

[0040] In some embodiments, the data processing module 20 is used to acquire specific parameters of the target patient, overlay these specific parameters with a baseline exercise safety assessment scale to obtain a corrected exercise safety level and an individualized effective exercise dose target range. The specific parameters include Wagner classification of foot ulcers, ulcer area, ankle-brachial index (ABI), peripheral neuropathy score, and blood glucose fluctuation level. A non-weight-bearing postural exercise program is generated to guide the target patient through a cycle of raising, holding, and lowering the affected limb. Exercise signals are acquired in real time and converted into gravitational potential energy changes. The actual effective exercise dose is determined based on the accumulated gravitational potential energy changes. Exercise dose, including the phase and amplitude of the exercise cycle; simultaneous acquisition of plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters of the target patient during non-weight-bearing induced exercise; the obtained peak plantar pressure, wound-side temperature change rate, and perfusion index ratio relative to baseline are used as safety constraints; when the actual effective exercise dose is within the target range and the safety constraints are not exceeded, the non-weight-bearing induced exercise program is maintained; otherwise, the exercise parameters are automatically adjusted or intermittent pneumatic compression is switched; exercise safety risk classification and early warning are performed based on the wound-side temperature change rate, perfusion index ratio relative to baseline, and actual effective exercise dose. In some embodiments, these specific parameters can be retrieved from a database based on patient information, such as by entering the patient's unique ID through an interactive interface to obtain the specific parameters stored in the database.

[0041] In some embodiments, the data processing module 20 performs individualized correction of the target range for effective exercise dose by: using the dose range of the baseline exercise safety level as a benchmark, and correcting the upper limit of the dose downward and narrowing the dose range based on at least one of the following: increased Wagner grade, increased ulcer area, decreased ABI, increased peripheral neuropathy score, and increased blood glucose fluctuation level; and correcting the lower limit of the dose upward for Charcot foot without active ulcers or high-risk contralateral limbs.

[0042] In some embodiments, the data processing module 20 performs the calculation of the change in gravitational potential energy by using the length of the affected limb as the basis. With the amplitude of the inclination angle within the period according to Calculate the change in potential energy over a single period, where This is an estimate of the limb's mass. For gravitational acceleration, only periods where both amplitude and duration reach the preset effective threshold are included in the cumulative calculation.

[0043] In some embodiments, the data processing module 20 sets safety constraints including: the peak pressure of the plantar region is not greater than a preset plantar safety threshold; the increase in temperature at the same site on the wound side relative to the pre-exercise baseline is not greater than a preset temperature safety threshold; the perfusion index is not lower than a preset multiple of the baseline value; and the plantar safety threshold is set according to the Wagner classification and the ulcer site.

[0044] In some embodiments, the data processing module 20 automatically adjusts the motion parameters including: reducing the elevation amplitude and motion frequency to a preset safe level; pausing the active elevation motion and switching to passive reflux promotion driven by the intermittent pneumatic pressurization device, and applying lower pressure or no pressure to the limb with ulcers than the contralateral limb; and also stopping the motion and outputting a safety warning.

[0045] In some embodiments, the data processing module 20 further includes periodically acquiring specific parameters of the target patient and dynamically adjusting the individualized effective exercise dose target range according to the degree of change in the parameters.

[0046] In some embodiments, the data processing module 20 further includes: calibrating the target patient, including using the change in venous return velocity measured by ultrasound Doppler or magnetic resonance 4D Flow of the target patient as a reference, and performing individualized calibration and periodic updates on the mapping relationship between the change in gravitational potential energy and the effective exercise dose.

[0047] In some embodiments, the sensing module 1020 includes a nine-axis tilt / accelerometer 11 (sampling rate ≥ 50 Hz) disposed on the thigh segment of the affected limb, a shoe insole-type foot pressure sensor 12 (at least 5 zones), a thermal temperature sensor 13 (accuracy ± 0.1 ℃) applied to the same location on both lower legs, and a finger / toe photoplethysmography (PPG) sensor 14; the data processing module performs motion cycle recognition, potential energy conversion, dose accumulation, constraint determination, and early warning calculation; the motion guidance module guides the rise-hold-lower rhythm by voice or vibration; and the pneumatic assist module is an intermittent inflation pressurization device with independently adjustable pressure on both sides.

[0048] This invention also provides an electronic device, which includes a processor and a memory; The memory stores the program; The processor executes a program to perform the aforementioned deep vein thrombosis monitoring and early warning method; the electronic device has the function of carrying and running the deep vein thrombosis monitoring and early warning software system provided in the embodiments of the present invention, such as a personal computer, minicomputer, mainframe, workstation, network or distributed computing environment, standalone or integrated computer platform, or communicating with charged particle tools or other imaging devices, etc.

[0049] This invention also provides a computer-readable storage medium storing a program that is executed by a processor to implement the deep vein thrombosis monitoring and early warning method described above.

[0050] In some alternative embodiments, the functions / operations mentioned in the block diagrams may not occur in the order shown in the operation diagrams. For example, depending on the functions / operations involved, two consecutively shown blocks may actually be executed substantially simultaneously, or the blocks may sometimes be executed in reverse order. Furthermore, the embodiments presented and described in the flowcharts of this invention are provided by way of example to provide a more comprehensive understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented in the embodiments of this invention. Alternative embodiments are contemplated, in which the order of various operations is changed and sub-operations described as part of a larger operation are executed independently.

[0051] This invention also discloses a computer program product or computer program, which includes computer instructions stored in a computer-readable storage medium. A processor of a computer device can read the computer instructions from the computer-readable storage medium and execute the computer instructions, causing the computer device to perform the aforementioned deep vein thrombosis monitoring and early warning method.

[0052] Furthermore, although the invention has been described in the context of functional modules, it should be understood that, unless otherwise stated, one or more of the described functions and / or features may be integrated into a single physical device and / or software module, or one or more functions and / or features may be implemented in a separate physical device or software module. It is also understood that a detailed discussion of the actual implementation of each module is unnecessary for understanding the invention. Rather, considering the properties, functions, and internal relationships of the various functional modules in the apparatus disclosed in the embodiments of the invention, the actual implementation of the module will be understood within the scope of conventional skill of an engineer. Therefore, those skilled in the art can implement the invention as set forth in the claims using ordinary techniques without excessive experimentation. It is also understood that the specific concepts disclosed are merely illustrative and are not intended to limit the scope of the invention, which is determined by the full scope of the appended claims and their equivalents.

[0053] If the aforementioned functions are implemented as software functional units and sold or used as independent products, they can be stored in a computer-readable storage medium. Based on this understanding, the technical solution of this invention, essentially, or the part that contributes to the prior art, or a portion of the technical solution, can be embodied in the form of a software product. This computer software product is stored in a storage medium and includes several instructions to cause a computer device (which may be a personal computer, server, or network device, etc.) to execute all or part of the steps of the methods described in the various embodiments of this invention. The aforementioned storage medium includes various media capable of storing program code, such as USB flash drives, portable hard drives, read-only memory (ROM), random access memory (RAM), magnetic disks, or optical disks.

[0054] The logic and / or steps represented in the flowchart or otherwise described herein, for example, can be considered as a sequenced list of executable instructions for implementing logical functions, and can be embodied in any computer-readable medium for use by, or in conjunction with, an instruction execution system, apparatus, or device (such as a computer-based system, a processor-included system, or other system that can fetch and execute instructions from, an instruction execution system, apparatus, or device). For the purposes of this specification, "computer-readable medium" can be any means that can include, store, communicate, propagate, or transmit programs for use by, or in conjunction with, an instruction execution system, apparatus, or device.

[0055] More specific examples of computer-readable media (a non-exhaustive list) include: electrical connections (electronic devices) having one or more wires, portable computer disk drives (magnetic devices), random access memory (RAM), read-only memory (ROM), erasable and editable read-only memory (EPROM or flash memory), fiber optic devices, and portable optical disc read-only memory (CDROM). Furthermore, computer-readable media can even be paper or other suitable media on which the program can be printed, because the program can be obtained electronically, for example, by optically scanning the paper or other medium, followed by editing, interpreting, or otherwise processing as necessary, and then stored in computer memory.

[0056] It should be understood that various parts of the present invention can be implemented in hardware, software, firmware, or a combination thereof. In the above embodiments, multiple steps or methods can be implemented in software or firmware stored in memory and executed by a suitable instruction execution system. For example, if implemented in hardware, as in another embodiment, it can be implemented using any one or a combination of the following techniques known in the art: discrete logic circuits having logic gates for implementing logical functions on data signals, application-specific integrated circuits (ASICs) having suitable combinational logic gates, programmable gate arrays (PGAs), field-programmable gate arrays (FPGAs), etc.

[0057] In the description of this specification, references to terms such as "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0058] Although embodiments of the invention have been shown and described, those skilled in the art will understand that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.

[0059] The above is a detailed description of the preferred embodiments of the present invention, but the present invention is not limited to the embodiments described. Those skilled in the art can make various equivalent modifications or substitutions without departing from the spirit of the present invention, and these equivalent modifications or substitutions are all included within the scope defined by the claims of this application.

Claims

1. A method for monitoring and early warning of deep vein thrombosis, characterized in that, include: Specific parameters of the target patients were obtained and superimposed on the baseline scale for exercise safety assessment to obtain the corrected exercise safety level and individualized effective exercise dose target range. The specific parameters included Wagner grade of foot ulcer, ulcer area, ankle-brachial index (ABI), peripheral neuropathy score and blood glucose fluctuation level. A non-weight-bearing postural drive exercise program is generated, which is used to guide the target patient to perform the exercise cycle of raising, holding and lowering the affected limb in sequence; Motion signals are acquired in real time and converted into changes in gravitational potential energy. The actual effective motion dose is determined based on the accumulated changes in gravitational potential energy. The motion signals include the phase and amplitude of the motion cycle. Simultaneously collect plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters of the target patient when performing non-weight-bearing posture-driven exercise. The obtained plantar pressure peak, wound side temperature change rate, and perfusion index relative to baseline are used as safety constraints. When the actual effective exercise dose is within the target range and the safety constraints are not exceeded, the non-weight-bearing body position driven exercise program is maintained; otherwise, the exercise parameters are automatically adjusted or the intermittent pneumatic assist is switched. Exercise safety risk classification and early warning are based on the wound side temperature change rate, perfusion index ratio relative to baseline, and actual effective exercise dose.

2. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The correction methods for the individualized effective exercise dose target range include: Based on the dose range of the baseline exercise safety level, the upper limit of the dose is adjusted downward and the dose range is narrowed according to at least one of the following: increased Wagner grade, increased ulcer area, decreased ABI, increased peripheral neuropathy score, and increased blood glucose fluctuation level; for Charcot foot without active ulcers or high-risk contralateral limbs, the lower limit of the dose is adjusted upward.

3. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The calculation method for the change in gravitational potential energy includes: Based on the length of the affected limb With the amplitude of the change in inclination angle within the period according to Calculate the change in potential energy over a single period, where This is an estimate of the limb's mass. For gravitational acceleration, only periods where both amplitude and duration reach the preset effective threshold are included in the cumulative calculation.

4. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The security constraints include: The peak pressure of the plantar region is not greater than the preset plantar safety threshold; the increase in temperature at the same site on the wound side relative to the pre-exercise baseline is not greater than the preset temperature safety threshold; the perfusion index is not lower than a preset multiple of the baseline value; the plantar safety threshold is set according to the Wagner classification and the ulcer site.

5. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The automatic adjustment of motion parameters includes: The elevation range and movement frequency are reduced to the preset safe level; Suspend active elevation exercises and switch to passive reflux promotion driven by intermittent pneumatic compression device, and apply lower compression pressure or no pressure to the limb with ulcers than the contralateral limb. It also includes stopping the movement and issuing a safety warning.

6. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The method further includes: The system periodically acquires specific parameters of the target patient and dynamically adjusts the individualized effective exercise dose target range based on the degree of parameter change.

7. The method for monitoring and early warning of deep vein thrombosis according to claim 1, characterized in that, The method further includes: The target patients are calibrated, including using the changes in venous return velocity measured by Doppler ultrasound or 4D Flow magnetic resonance as a reference, and the mapping relationship between the change in gravitational potential energy and the effective exercise dose is individually calibrated and updated periodically.

8. A deep vein thrombosis monitoring and early warning device for implementing the method of any one of claims 1-7, characterized in that, include: Sensing module, data processing module, early warning module, air pressure-assisted module, and motion guidance module; The data processing module is connected to the sensing module, the early warning module, the motion guidance module, and the pneumatic assist module, respectively; the pneumatic assist module is installed on the affected limb of the target patient; The sensing module is used to collect motion data of the target patient, including motion signals, plantar pressure, bilateral limb temperature at the same site, and photoplethysmography perfusion parameters. The data processing module is used to generate guidance instructions, sports safety risk classification warnings, and adjustment instructions based on the motion data. The motion guidance module is used to generate a non-weight-bearing body position driving motion scheme according to the guidance instructions; The early warning module performs early warning processing based on the sports safety risk classification warning; The pneumatic assist module is used to intermittently inflate and pressurize the affected limb according to adjustment commands.

9. The deep vein thrombosis monitoring and early warning device according to claim 8, characterized in that, The pneumatic assist module uses an intermittent inflation device with independently set pressure on both sides, which is used to apply a lower pressure or no pressure to the limb with ulcers on the side with ulcers.

10. An electronic device, characterized in that, Including the processor and memory; The memory is used to store programs; The processor executes the program to implement the deep vein thrombosis monitoring and early warning method as described in any one of claims 1-7.

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