Blood glucose detection module of composite wavelength light source and wearable device thereof

Abstract

The present application provides a blood glucose detection module of a composite wavelength light source and a wearable device thereof. The blood glucose detection module of the composite wavelength light source comprises a light emitting component and a light sensing component. The light emitting component comprises a plurality of light source elements. The plurality of light source elements emit a plurality of light rays to a subject to be measured. The wavelength range of the plurality of light rays is 700 nm to 1700 nm. The plurality of light rays comprises at least one first waveband light and at least one second waveband light. The at least one first waveband light is used to correct the deep optical properties of the skin tissue. The at least one second waveband light is used to detect the absorption intensity of the blood glucose. The light sensing component is arranged adjacent to the light emitting component. The light sensing component is used to receive a plurality of diffuse reflection light signals reflected after the plurality of light rays irradiate the subject to be measured, so as to obtain the optical properties of the blood glucose concentration of the subject to be measured.

Description

Technical Field

[0001] This invention relates to a blood glucose detection module and wearable device with a composite wavelength light source, and particularly to a light-emitting diode light source that can simultaneously provide composite wavelength light in the wavelength range from near-infrared to short-wave infrared light, and a blood glucose detection module and wearable device that perform non-invasive blood glucose concentration detection by diffuse reflectance infrared spectroscopy. Background Technology

[0002] In recent years, to reduce the discomfort caused by invasive blood glucose measurements, various non-invasive blood glucose concentration detection technologies have been developed. Among the known non-invasive blood glucose concentration detection technologies, common methods involve using the spectral absorption characteristics of near-infrared (NIR) or short-wave infrared (SWIR) light to detect the selective absorption behavior of glucose molecules in biological tissues at specific wavelengths, thereby estimating blood glucose concentration. Some technologies use a single-wavelength laser source as the excitation light. Raman photons collide with glucose molecules at different depths within skin tissue, and the resulting Raman scattered light with varying kinetic energies is collected. The blood glucose concentration is then calculated through Raman spectrum comparison and analysis. Furthermore, some studies combine spectral imaging systems, transmissive laser optical paths, and correction algorithms to improve detection accuracy and calculation precision.

[0003] However, the aforementioned detection systems still generally have drawbacks. First, focusing the energy of a single-wavelength laser source requires complex optical component designs (e.g., lenses, mirrors, and dichroic mirrors) to compensate for energy loss caused by differences in tissue depth. This not only increases system size and cost but also hinders miniaturization and wearable applications. Second, because Raman signals are relatively weak, they require high-power laser excitation combined with a highly sensitive spectrometer, leading to high energy consumption and the potential risk of overheating of the detection device. Furthermore, most existing technologies struggle to simultaneously cover glucose signal characteristics at different tissue depths, making detection results susceptible to environmental changes or individual differences, and accuracy and stability still need improvement.

[0004] In view of this, the present invention proposes a blood glucose detection module and wearable device with a composite wavelength light source, in order to improve the problems of single-wavelength laser light sources in the prior art, such as the need to compensate for energy loss through lens optical path focusing, insufficient sensing accuracy, and complex structure that is difficult to miniaturize. Summary of the Invention

[0005] The purpose of this invention is to provide a novel blood glucose detection module and wearable device based on a composite wavelength light source. The blood glucose detection module of this invention employs a composite wavelength light-emitting diode (LED) light source that simultaneously covers the near-infrared to short-wave infrared light bands (e.g., wavelength range of 700 nm to 1700 nm), replacing the traditional laser light source with only a single wavelength. By utilizing the differences in penetration ability of different wavelength bands into different depths of tissue, glucose signals are detected in layers. The high energy characteristics of short wavelengths compensate for the low energy of long wavelengths, thereby increasing wavelength characteristic information and improving the accuracy of blood glucose concentration correction. Furthermore, this invention utilizes the wide-angle light source characteristics of LEDs to achieve optical diffuse reflection, eliminating the need for focusing optical elements or fiber optic transmission paths required for Raman spectroscopy, thus simplifying the optical system structure and effectively reducing the device size, enabling a miniaturized wearable device design suitable for non-invasive blood glucose detection. Overall, the blood glucose detection module provided by this invention effectively realizes blood glucose detection applications that combine non-invasiveness, high sensitivity, high accuracy, and miniaturization.

[0006] To achieve the above objectives, the present invention provides a blood glucose detection module with a composite wavelength light source, comprising a light-emitting component and a photosensing component. The light-emitting component includes multiple light source elements. These elements emit multiple rays of light to the test object, the wavelengths of which range from 700 nanometers (nm) to 1700 nanometers (nm), and each ray includes at least one first-band light and at least one second-band light. The at least one first-band light is used to correct the depth optical properties of skin tissue, and the at least one second-band light is used to detect the absorption intensity of blood glucose. The photosensing component is disposed adjacent to the light-emitting component and is used to receive multiple diffuse reflection light signals reflected after the multiple rays illuminate the test object, thereby obtaining the optical properties of the blood glucose concentration of the test object.

[0007] In one embodiment, the wavelength range of at least one first band of light is from 700 nanometers to 1100 nanometers.

[0008] In one embodiment, at least one second-band light has a wavelength range of 1100 nanometers to 1700 nanometers.

[0009] In one embodiment, the blood glucose detection module further includes a substrate, and a light-emitting component and a light-sensing component are disposed on the same side of the substrate.

[0010] In one embodiment, a light-emitting component and a light-sensing component are disposed correspondingly to each other, with the light-emitting component disposed at one end of one side of the substrate and the light-sensing component disposed at the other end of the same side of the substrate.

[0011] In one embodiment, the light source element is a plurality of light-emitting diodes.

[0012] In one embodiment, the light sensing component is composed of a plurality of photodiodes.

[0013] In another embodiment, the blood glucose detection module further includes a filter configured to selectively allow at least one first band of light or at least one second band of light to pass through.

[0014] In one embodiment, the sensing component further includes a data processing unit for receiving and analyzing the spectral signal of the diffuse reflected light signal, and outputting information on the corresponding blood glucose concentration by comparing it with a reference spectrum.

[0015] The present invention also provides a wearable device comprising the aforementioned blood glucose detection module with a composite wavelength light source, a housing, a power component, and at least one printed circuit board assembly. The housing is configured to house the blood glucose detection module with the composite wavelength light source. The power component is disposed within the housing, coupled to the blood glucose detection module with the composite wavelength light source, and configured to provide power. At least one printed circuit board assembly is disposed within the housing, coupled to the blood glucose detection module with the composite wavelength light source, and configured to control the operation of the blood glucose detection module with the composite wavelength light source.

[0016] Other objects of the present invention, as well as the technical means and embodiments of the present invention, can be understood by those skilled in the art after referring to the accompanying drawings and the embodiments described below. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the blood glucose detection module of the composite wavelength light source of the present invention; Figure 2 This is a schematic diagram of the light source element in the blood glucose detection module of the composite wavelength light source of the present invention; and Figure 3 This is a cross-sectional schematic diagram of the wearable device of the present invention. Detailed Implementation

[0018] The following embodiments will explain the content of this invention. These embodiments are not intended to limit the implementation of this invention to any specific environment, application, or special method as described in the embodiments. Therefore, the descriptions of the embodiments are merely illustrative and not intended to limit the invention. It should be noted that in the following embodiments and drawings, devices not directly related to this invention have been omitted and are not shown, and the dimensional relationships between the various devices in the drawings are for ease of understanding only and are not intended to limit the actual scale.

[0019] Please refer to Figure 1As shown in the figure, a blood glucose detection module 100 with a composite wavelength light source according to an embodiment of the present invention includes a light-emitting component 1, a light-sensing component 2, and a substrate 3. The substrate 3, serving as a support structure for all components, is located at the bottom layer of the blood glucose detection module 100, and the light-emitting component 1 and the light-sensing component 2 are disposed on the upper surface of the substrate 3. Furthermore, the present invention may also include a filter 4 (see…). Figure 2 The filter 4 is positioned above the light-emitting component 1 and the photosensing component 2. Its specific position can be adjusted according to actual detection needs and is not limited here. The main purpose of the blood glucose detection module 100 of the composite wavelength light source of the present invention is to emit composite light with multiple different wavelengths to the test object through the light-emitting component 1. When the light irradiates glucose molecules in the test object and generates a diffuse reflection light signal, the photosensing component 2 is used to receive the diffuse reflection light signal, thereby obtaining the optical characteristics reflecting the blood glucose concentration of the test object.

[0020] Secondly, please refer to... Figure 2The light-emitting component 1 includes multiple light source elements 11. Each light source element 11 serves as the light emission source of the light-emitting component 1, emitting multiple light rays with wavelengths ranging from 700 nm to 1700 nm to the object under test. The light rays include at least one first-band light and at least one second-band light. In an embodiment, the first-band light has a wavelength range of 700 nm to 1100 nm (belonging to the near-infrared (NIR) range). This first-band light is used to correct the depth optical properties of skin tissue to compensate for the scattering and absorption effects in skin layers of different depths (e.g., epidermis, dermis, and stratum corneum). On the other hand, the second-band light has a wavelength range of 1100 nm to 1700 nm (belonging to the short-wave infrared (SWIR) range). This second-band light can detect the absorption peak of blood glucose molecules in this band (i.e., detect the absorption intensity of blood glucose), thereby obtaining its absorption spectrum signal. In a preferred embodiment, the light source element 11 can be a light-emitting diode (LED) light source, and can be configured in the form of LED chips according to different wavelengths to provide light of composite wavelengths. Furthermore, the material of the light-emitting diode can be gallium arsenide (GaAs), indium phosphide (InP), or indium gallium arsenide (InGaAs). The material selection can be flexibly adjusted according to the target wavelength to be detected, and there are no limitations here. For example, in one embodiment of the present invention, the blood glucose detection module 100 is configured with four light source elements 11 that can emit one first-band light and three second-band lights. The first-band light has a shorter wavelength and higher energy, and has better tissue penetration ability, which can penetrate to the deep layers of the skin (such as below the dermis) and obtain the diffuse reflection light signal generated by deep glucose molecules for depth correction. The second-band light has a longer wavelength and lower energy than the first-band light, but has a better absorption rate for glucose molecules, which helps to improve the sensitivity and accuracy of blood glucose concentration detection. This composite wavelength design has excellent tissue penetration ability, and the sensing depth can reach the dermis, effectively detecting the absorption spectrum signal of blood glucose molecules at different depths, thereby obtaining spectral information with higher resolution and accuracy. It should be noted that the number and wavelength of the light-emitting diode light source and the corresponding emitted first-band and second-band light in this embodiment can be adjusted according to the actual molecular characteristics and the conditions of the test sample, and are not limited here.

[0021] The photosensitive component 2 is used to receive multiple reflected light signals after the light emitted by the light-emitting component 1 is diffusely reflected by the skin tissue. These reflected light signals mainly originate from diffuse reflection signals at different depths of the skin tissue and contain spectral information related to blood glucose absorption. Specifically, after the light is emitted from the light source element 11 of the light-emitting component 1, it passes through a filter 4, allowing either a first-band or second-band light to selectively pass through and irradiate the skin tissue. The photosensitive component 2 then collects the diffusely reflected light signals from the skin tissue. The photosensitive component 2 further includes a data processing unit 21, which processes the spectral information of the received diffusely reflected light signals and converts it into corresponding electrical signals. The system then calculates the corresponding blood glucose concentration by comparing the signal with a reference spectrum. In this embodiment, the photosensitive component 2 of the present invention is composed of multiple photodiodes (PDs). Each independent photodiode can be used to convert the received diffusely reflected light signals of a specific wavelength into electrical signals for a specific wavelength band.

[0022] In detail, in another embodiment of the invention, such as Figure 2 As shown, the filter 4 can be positioned above the light-emitting component 1 and the light-sensing component 2 according to actual sensing requirements. The filter 4 can be positioned on the same side of the substrate 3 as the light-emitting component 1 and the light-sensing component 2 to selectively allow the first-band light or the second-band light to pass through, ensuring the wavelength of the required incident and reflected light signals, and effectively suppressing stray light interference. By blocking background light with the same wavelength as the target but not originating from the test object, the signal-to-noise ratio (SNR) can be improved, thereby enhancing the accuracy and stability of optical analysis. In this embodiment, the filter 4 can be a band-pass filter (BPF), which only allows light within a specific wavelength range to pass through, filtering out other non-target wavelength light.

[0023] The substrate 3 supports the light-emitting component 1, the photosensing component 2, and the filter 4, ensuring the relative positional stability of these components. The substrate 3 can be in the form of a printed circuit board, possessing good thermal stability and structural strength. In this embodiment, the light-emitting component 1 and the photosensing component 2 are correspondingly disposed on the same side of the substrate 3, with a specific spacing to improve the collection efficiency of diffuse reflection light signals. This spacing can be adjusted according to the wavelength of the light source and actual design requirements. Specifically, the blood glucose detection module 100 of this invention only requires the light source element 11 of the light-emitting component 1 to be disposed at one end of one side of the substrate 3, and the photosensing component 2 to be disposed at the corresponding other end of that side of the substrate 3. This design can reduce the size of the package while maintaining the sensitivity and accuracy of the detection. Compared with prior art, this invention utilizes the wide-angle light source characteristics of light-emitting diodes to achieve optical diffuse reflection, eliminating the need for a prescribed optical path structure, thereby reducing the use of lenses and optical components, making it more suitable for wearable devices and improving their portability and practicality.

[0024] In this embodiment, the module configuration and operation flow of the blood glucose detection module 100 of the composite wavelength light source of the present invention are as follows. The light-emitting component 1 includes multiple light source elements 11, used to emit multiple light rays including first-band light and second-band light, and irradiate the skin tissue. In another embodiment, the light rays can be selectively filtered through a filter 4 to ensure that light within a specific wavelength range passes through before irradiating the skin tissue. After being excited by the light, the skin tissue generates diffusely reflected light signals. These reflected light signals are filtered through the same filter 4 and collected by the photosensitive component 2. The photosensitive component 2 transmits the reflected light signals to the data processing unit 21 for spectral analysis and signal processing to calculate the blood glucose concentration.

[0025] In this embodiment, the test subject is human skin tissue. The main target molecule detected by the blood glucose detection module 100 of the present invention is blood glucose molecules in human skin tissue.

[0026] It should be noted that glucose enters the tissue fluid from blood vessels via osmosis, thus glucose molecules are present in different skin layers. To improve detection accuracy, correction can be performed by comparing optical signals from skin layers at different depths. As can be seen from the absorption spectrum of glucose concentration, concentration correction can be performed using multi-band detection results, and specific bands sensitive to high glucose concentrations can be selected. In this embodiment, a specific wavelength in the second band of light exhibits significant absorption characteristics for glucose and can be used as a characteristic wavelength for glucose identification. Alternatively, wavelengths correlated with changes in glucose concentration can be selected, and concentration can be determined by the intensity of the scattered light they produce. Furthermore, considering the physiological differences in skin thickness and stratum corneum structure caused by different races and genders, and the varying degrees of interference from proteins and lipids in the blood on different wavelengths of light, using only a single wavelength for judgment may lead to misjudgment. To reduce the risk of interference and misjudgment, this invention uses a composite wavelength light source for illumination and cross-compares infrared absorption spectra using multi-wavelength optical signals to more accurately determine glucose concentration, effectively improving the overall stability and reliability of the analysis.

[0027] In this embodiment, the present invention further provides a wearable device 1000, such as... Figure 3 As shown, the wearable device 1000 includes a blood glucose detection module 100 with a composite wavelength light source as described above, a housing 200, a power component 300, and at least one printed circuit board assembly 400. The housing 200 houses the blood glucose detection module 100, the power component 300, and the at least one printed circuit board assembly 400, thereby protecting the internal components and ensuring stable contact between the device and the subject. The power component 300 is electrically coupled to the at least one printed circuit board assembly 400 and configured to provide the power required to drive the blood glucose detection module 100. The at least one printed circuit board assembly 400 is coupled to the blood glucose detection module 100 and configured to control the operation of the blood glucose detection module 100 (including functions such as light source driving, signal selection, and data processing). It should be noted that in this embodiment, the positions of the blood glucose detection module 100, housing 200, power component 300, and at least one printed circuit board assembly 400 can be appropriately adjusted and changed according to actual application requirements, and are not limited herein. Through the above design, the wearable device 1000 of the present invention can achieve miniaturized and non-invasive blood glucose concentration detection, and has good portability and ease of use.

[0028] The blood glucose detection module 100 of the present invention employs a detection component with a composite wavelength light source, and has technical advantages such as multi-wavelength selectivity, high detection accuracy, and simplified structure. Its light-emitting component 1 includes a light source element 11 that can simultaneously emit multiple near-infrared and short-wave infrared rays with wavelengths ranging from 700 nm to 1700 nm. Through the composite wavelength light provided by the light source element 11, depth correction can be performed by selecting an appropriate first-band light based on the required tissue depth, while spectral identification is performed using specific wavelengths of the second-band light that have high absorption characteristics for glucose, and concentration is calculated using multi-wavelength optical signals. Furthermore, by integrating the spectral information obtained from the first and second-band light, the resolution and accuracy of the blood glucose absorption signal are improved. In addition, the present invention utilizes the wide-angle light emission characteristics of the light-emitting diode to achieve an optical diffuse reflection detection mechanism, eliminating the need for additional optical focusing elements, effectively simplifying the optical path and structural design, and thus achieving a miniaturized detection structure. Combining the advantages of the aforementioned optical design, high integration, and low power consumption, the blood glucose detection module 100 proposed in this invention can be effectively applied to wearable devices 1000, providing a novel, high-efficiency, and portable blood glucose concentration detection solution.

[0029] The above embodiments are merely illustrative of the present invention and to explain its technical features, and are not intended to limit the scope of protection of the present invention. Any changes or equivalent arrangements that can be easily made by those skilled in the art are within the scope of protection of the present invention, and the scope of protection of the present invention should be determined by the claims.

[0030] [Symbol Explanation] 1000 wearable devices Blood glucose detection module with 100 composite wavelength light source 200 housing 300 power components 400 Printed Circuit Board Assembly 1. Light-emitting components 11 Light source elements 2. Light sensing components 21 Data Processing Unit 3 substrate 4. Filters.

Claims

1. A blood glucose detection module using a composite wavelength light source, the blood glucose detection module comprising: A light-emitting component includes multiple light source elements that emit multiple light rays to a test object. The wavelengths of these multiple light rays range from 700 nanometers to 1700 nanometers, and each light ray includes at least one first-band light and at least one second-band light. The at least one first-band light is used to correct the depth optical properties of skin tissue, and the at least one second-band light is used to detect the absorption intensity of blood glucose. A photosensitive component, disposed adjacent to the light-emitting component, is used to receive multiple diffuse reflection light signals reflected after the multiple light rays illuminate the test subject, so as to obtain the optical characteristics of the blood glucose concentration of the test subject.

2. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The wavelength range of the at least one first band of light is from 700 nanometers to 1100 nanometers.

3. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The wavelength range of the at least one second-band light is from 1100 nanometers to 1700 nanometers.

4. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The blood glucose detection module of the composite wavelength light source also includes a substrate, and the light-emitting component and the light-sensing component are disposed on the same side of the substrate.

5. The blood glucose detection module with a composite wavelength light source according to claim 4, wherein, The light-emitting component and the light-sensing component are disposed correspondingly to each other, with the light-emitting component disposed at one end of one side of the substrate and the light-sensing component disposed at the other end of the same side of the substrate.

6. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The light source element is a plurality of light-emitting diodes.

7. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The light sensing component is composed of multiple photodiodes.

8. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The blood glucose detection module of the composite wavelength light source also includes a filter configured to selectively allow the at least one first band light or the at least one second band light to pass through.

9. The blood glucose detection module with a composite wavelength light source according to claim 1, wherein, The photosensitive component further includes a data processing unit, which receives and analyzes the spectral signal of the diffuse reflection light signal, and outputs information on the corresponding blood glucose concentration by comparing it with a reference spectrum.

10. A wearable device, the wearable device comprising: A blood glucose detection module with a composite wavelength light source as described in any one of claims 1 to 9; The housing is configured to house the blood glucose detection module of the composite wavelength light source; A power element is disposed within the housing, the power element being coupled to the blood glucose detection module of the composite wavelength light source and configured to provide power; as well as At least one printed circuit board assembly is disposed within the housing, the at least one printed circuit board assembly being coupled to the blood glucose detection module of the composite wavelength light source and configured to control the operation of the blood glucose detection module of the composite wavelength light source.

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