A mouse intelligent intravenous injection device for drug efficacy detection and a method thereof

Abstract

The application discloses a kind of drug efficacy detection mouse intelligent intravenous injection device and method thereof, belong to experimental animal dosing equipment technical field, including detection platform and injector, still including rotary flip type mouse fixing mechanism, adjustable lifting type tail root fixing mechanism and follow-up type tail tip fixing mechanism;Rotary flip type mouse fixing mechanism is installed in the middle part of detection platform;Rotary flip type mouse fixing mechanism includes rotating assembly, limiting cylinder, head limiting assembly and tail limiting assembly;Adjustable lifting type tail root fixing mechanism is installed in the front side of detection platform;Adjustable lifting type tail root fixing mechanism includes lifting assembly and pressing assembly;Follow-up type tail tip fixing mechanism is connected with lifting assembly.By the above-mentioned mode, the quick loading and limiting of mouse body are realized, the mouse tail intravenous side can be turned to the optimal injection angle of upward, without adjusting the hand posture of operator to adapt to the needle insertion direction;And the circumferential auxiliary limiting of tail can be realized, to reduce the injection deviation caused by mouse wriggling.

Description

Technical Field

[0001] This invention relates to the field of experimental animal drug delivery equipment technology, specifically to a smart intravenous injection device and method for detecting drug efficacy in mice. Background Technology

[0002] Mice are the most widely used experimental model animals in the biomedical field for pharmacodynamic evaluation, pharmacological and toxicological analysis, tumor model construction, and immune mechanism research. Tail vein injection is the core operation method for systemic drug administration in mice.

[0003] Chinese patent CN222304097U discloses a rat tail vein injection device, including a rat tail fixing mechanism and an injection needle advancing mechanism. The rat tail fixing mechanism includes a placement boss, two winding mechanisms disposed on the side of the placement boss, and two straps near the end of the placement boss. The top of the placement boss has a receiving groove with a gradually changing bottom height. One end of each strap is connected to one side of the placement boss, and the other end passes through the side wall of the receiving groove and extends to the other side of the placement boss, where it is connected to the two winding mechanisms respectively. However, this device still has the following problems in use:

[0004] 1. The fixation tube is a one-piece structure. When injecting and fixing mice, it is necessary to pull the mouse by the tail and drag it into the fixation tube from the back to the front. At this time, the mouse is prone to stress and the insertion into the tube is difficult.

[0005] Second, during injection, the tip of the needle still needs to be pressed down and stabilized by the operator with one hand. Holding the needle with one hand is not stable enough and can easily lead to problems such as vein puncture and extravasation of the drug, which will affect the accuracy of the dosage.

[0006] Based on this, the present invention designs an intelligent intravenous injection device and method for detecting drug efficacy in mice to solve the above problems. Summary of the Invention

[0007] In view of the above-mentioned shortcomings of the existing technology, the present invention provides a smart intravenous injection device and method for drug efficacy detection in mice.

[0008] To achieve the above objectives, the present invention provides the following technical solution:

[0009] A smart intravenous injection device for detecting drug efficacy in mice includes a testing platform and a syringe, as well as a rotating flip-top mouse fixation mechanism, an adjustable lifting tail root fixation mechanism, and a follow-up tail tip fixation mechanism.

[0010] A rotating flip-top mouse restraint mechanism for easy mouse fixation is installed in the middle of the testing table;

[0011] The rotating flip-top mouse restraint mechanism includes a rotating component, a limiting cylinder, a head limiting component, and a tail limiting component; the rotating component is connected to the testing stage; the limiting cylinder is connected to the rotating component; the head limiting component and the tail limiting component are respectively installed on the rear and front sides of the limiting cylinder;

[0012] A sliding groove is provided on the upper side of the limiting cylinder;

[0013] An adjustable lifting tail root fixation mechanism for limiting the tail root of mice is installed on the front side of the testing table.

[0014] The adjustable lifting tail root fixing mechanism includes a lifting component and a pressing component; the lifting component is installed in the middle of the front side of the inspection table; the pressing component is installed on the right side of the inspection table.

[0015] A follow-up tail tip fixation mechanism is connected to a lifting assembly for limiting the tail tip of mice and facilitating intravenous drug injection in mice.

[0016] A storage slot is provided on the right side of the testing station; several syringes for injecting drugs into mice are placed in the storage slot.

[0017] Furthermore, the follow-up tail tip fixing mechanism includes a one-way moving component, an arc-shaped placement plate, and a flip-pressing component; the one-way moving component is connected to the lifting component; the arc-shaped placement plate is installed on the front side of the one-way moving component; the flip-pressing component is connected to the arc-shaped placement plate;

[0018] Furthermore, the rotating assembly includes a bracket, a rotating control motor, a rotating gear, a driven half-gear ring, a rotating mounting ring, and a partition ring; the bracket is fixedly installed in the middle of the testing table; the rotating control motor is fixedly installed at the rear end of the bracket; the rotating gear is rotatably installed at the front end of the bracket; the output end of the rotating control motor is fixedly connected to the rotating gear; a partition groove is provided in the middle of the bracket; the partition ring is slidably connected to the partition groove; the partition ring is fixedly installed in the middle of the outer end of the rotating mounting ring.

[0019] The driven half-gear ring is fixedly installed on the front side of the outer end of the rotating mounting ring; the rotating gear meshes with the driven half-gear ring.

[0020] Both the bracket and the rotating mounting ring have movable grooves on their upper sides;

[0021] The limiting cylinder is fixedly installed in the middle of the rotating mounting ring;

[0022] Furthermore, the tail limiting assembly includes a flip cover, a first reset torsion spring, a locking ear plate, a locking screw, a locking nut, a plug ring, and a U-shaped limiting insert plate; the flip cover is rotatably mounted on the front right end of the limiting cylinder; the first reset torsion spring is wound around the connecting shaft between the flip cover and the limiting cylinder; one end of the first reset torsion spring is fixedly connected to the connecting shaft between the flip cover and the limiting cylinder.

[0023] The other end of the first reset torsion spring is fixedly connected to the limiting cylinder;

[0024] The first reset torsion spring ensures that the flip cover always has a tendency to rotate forward.

[0025] The locking ear plate is fixedly installed on the front left side of the limiting cylinder;

[0026] Both the locking ear plate and the left side of the flip cover have insertion holes; the locking screw is inserted into the insertion hole, and the locking nut is threadedly connected to the locking screw;

[0027] The insert rings are symmetrically and fixedly installed on the upper and lower front sides of the flip cover; the U-shaped limiting plate is inserted into the insert ring;

[0028] An arc-shaped groove is provided in the middle of the flip cover;

[0029] Furthermore, the lifting assembly includes a first U-shaped mounting plate, a lifting cylinder, a lifting guide rod, and a lifting plate; the first U-shaped mounting plate is fixedly installed on the lower side of the testing table; the lifting cylinder is fixedly installed in the lower middle part of the first U-shaped mounting plate; the lifting guide rod is slidably connected to the first U-shaped mounting plate; the lifting plate is fixedly connected to the output end of the lifting cylinder; the lifting plate is also fixedly connected to the lifting guide rod.

[0030] A tail root receiving groove is provided in the middle of the lifting plate;

[0031] Furthermore, the unidirectional movement assembly includes a second U-shaped mounting plate, a second locking screw, a second locking knob, a pressure ring, and an adjusting plate; the second U-shaped mounting plate is symmetrically fixedly installed on the left and right sides of the lifting plate;

[0032] The second locking screw is symmetrically fixedly installed on both the front and rear sides of the left end of the lifting plate;

[0033] The second locking knob is threadedly connected to the second locking screw; the pressure ring is fixedly installed on the right end of the second locking knob;

[0034] The adjusting plate and the second U-shaped mounting plate are in a limited sliding connection;

[0035] The arc-shaped placement plate is fixedly connected to the left and right adjustment plates;

[0036] Furthermore, a clearance groove is provided in the middle of the adjustment plate;

[0037] Furthermore, the flipping and pressing assembly includes an arc-shaped pressure plate, a second reset torsion spring, and a pressure roller; the arc-shaped pressure plate is symmetrically rotated and installed on the left and right sides of the arc-shaped placement plate; the second reset torsion spring is wound around the connecting shaft between the arc-shaped pressure plate and the arc-shaped placement plate; one end of the second reset torsion spring is fixedly connected to the connecting shaft between the arc-shaped pressure plate and the arc-shaped placement plate; the other end of the second reset torsion spring is fixedly connected to the arc-shaped placement plate.

[0038] Two pressure rollers are provided; and the pressure rollers are rotatably mounted on the left and right arc-shaped pressure plates via a damping shaft.

[0039] Furthermore, a contour groove is provided in the middle of the upper pressure roller;

[0040] Furthermore, the second reset torsion spring ensures that the arc-shaped pressure plate always tends to rotate upwards.

[0041] To better achieve the objectives of this invention, the present invention also provides a method for using a smart intravenous injection device for drug efficacy testing in mice, comprising the following steps:

[0042] Step 1: Remove the tail limiting component from the front of the limiting cylinder. Place the mouse to be tested with its head facing backward into the front of the limiting cylinder. The mouse will crawl backward along the inner wall of the limiting cylinder. The operator will hold the base of the mouse's tail with one hand and reset the tail limiting component to limit the mouse's tail.

[0043] Step 2: Pull the head limiting component forward along the limiting cylinder until the mouse's head is pressed against the head limiting component, thereby fixing the mouse's body.

[0044] Step 3: The rotating component controls the limiting cylinder to rotate 90 degrees, so that the side of the mouse tail faces upward. The lifting component moves upward to lift the base of the mouse tail from below, and the pressing component presses down on the base of the mouse tail from above, ensuring that the base of the mouse tail is limited by the lifting component and the pressing component.

[0045] Step 4: After the base of the mouse tail is positioned, the operator straightens the mouse tail and, based on the length of the mouse tail, pulls the one-way moving component forward a certain distance until the arc-shaped placement plate installed on the one-way moving component is aligned with the tip of the mouse tail.

[0046] Step 5: Control the flip-pressing component to rotate forward, place the mouse's tail in the placement slot on the arc-shaped placement plate, and then control the flip-pressing component to rotate and reset, so as to automatically press the tip of the mouse's tail.

[0047] Step Six: The operator takes out the syringe from the storage compartment, draws the drug to be tested, and then uses both hands to control the needle of the syringe to push it backward along the flip-compression assembly into the vein at the tip of the mouse's tail to inject the drug.

[0048] Compared with the prior art, the beneficial effects of this invention are as follows: 1. The rotating flip-top mouse fixation mechanism enables the rapid insertion and positioning of the mouse body, while driving the limiting cylinder to rotate around the axis, turning the mouse's tail vein to the optimal upward injection angle, eliminating the need for the operator to adjust their hand posture to match the needle insertion direction; and it can also achieve circumferential auxiliary positioning of the tail, reducing injection deviation caused by the mouse twisting.

[0049] 2. By adjusting the lifting tail root fixing mechanism and the follow-up tail tip fixing mechanism, the tail root and tail tip of the mouse are automatically pressed together, eliminating the need for the operator to manually press the tail. The syringe can be operated with both hands, which significantly improves the stability of the needle insertion process and reduces the risk of vein puncture and drug leakage.

[0050] 3. The follow-up tail tip fixing mechanism can be steplessly adjusted and locked along the length of the mouse tail to adapt to different strains of mice with different body and tail lengths; the upper pressure roller of the tail tip is equipped with a contour guide groove that matches the shape of the syringe to limit and guide the syringe, ensuring that the needle insertion angle is consistent with the direction of the tail vein, reducing the influence of the operator's experience on the injection accuracy, shortening the training cycle for novices, and improving the accuracy of drug dosage. Attached Figure Description

[0051] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the accompanying drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are merely some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without any creative effort.

[0052] Figure 1 This invention provides a three-dimensional intelligent intravenous injection device for detecting drug efficacy in mice. Figure 1 ;

[0053] Figure 2 This is a front view of a smart intravenous injection device for detecting drug efficacy in mice according to the present invention;

[0054] Figure 3 This invention provides a three-dimensional intelligent intravenous injection device for detecting drug efficacy in mice. Figure 2 ;

[0055] Figure 4 Partial three-dimensional representation of a rotating flip-top mouse restraint mechanism Figure 1 ;

[0056] Figure 5 for Figure 4 Enlarged view of point A in the middle;

[0057] Figure 6 for Figure 4 Enlarged view of point B in the middle;

[0058] Figure 7 Partial three-dimensional representation of a rotating flip-top mouse restraint mechanism Figure 2 ;

[0059] Figure 8 A 3D view of a partially cut-out rotating flip-top mouse restraint mechanism;

[0060] Figure 9 To adjust the local three-dimensional structure of the lifting tail root fixing mechanism and the follow-up tail tip fixing mechanism Figure 1 ;

[0061] Figure 10 To adjust the local three-dimensional structure of the lifting tail root fixing mechanism and the follow-up tail tip fixing mechanism Figure 2 .

[0062] The labels in the diagram represent:

[0063] 1. Testing table; 2. Rotating flip-top mouse restraint mechanism; 21. Bracket; 22. Rotary control motor; 23. Rotary gear; 24. Driven half-gear ring; 25. Rotating mounting ring; 26. Limiting cylinder; 27. Moving slide groove; 28. Sleeve; 29. ​​Conical cylinder; 210. Limiting roller; 211. First locking screw; 212. First locking knob; 213. Flip-top; 214. First return torsion spring; 215. Locking ear plate; 216. Locking screw; 217. Locking nut; 218. Arc groove; 219. Insert ring; 220. U-shaped limiting insert plate; 221. Partition slide groove; 222. 3. Partition ring; 4. Adjustable lifting tail root fixing mechanism; 5. First U-shaped mounting plate; 6. Lifting push cylinder; 7. Lifting guide rod; 8. Lifting plate; 9. Tail root receiving groove; 10. L-shaped mounting plate; 11. Tilting control motor; 2. Straight pressure plate; 32. Pressure groove; 4. Follow-up tail tip fixing mechanism; 5. Second U-shaped mounting plate; 6. Second locking screw; 7. Second locking knob; 8. Pressure ring; 9. Adjusting plate; 10. Avoidance slide groove; 11. Arc-shaped placement plate; 12. Arc-shaped pressure plate; 13. Second reset torsion spring; 14. Pressure roller; 15. Contouring groove; 16. Injector. Detailed Implementation

[0064] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0065] The terms "left," "right," "front," "back," "up," and "down" used in the following description refer to the orientation from the perspective of the front view.

[0066] Example 1: In some embodiments, please refer to the accompanying drawings. Figures 1-10 A smart intravenous injection device for detecting drug efficacy in mice includes a detection platform 1, a rotating flip-top mouse fixation mechanism 2, an adjustable lifting tail root fixation mechanism 3, a follow-up tail tip fixation mechanism 4, and a syringe 5.

[0067] A rotating flip-top mouse restraint mechanism 2, which facilitates the fixation of mice, is installed in the middle of the testing table 1;

[0068] The rotating flip-top mouse restraint mechanism 2 includes a rotating component, a limiting cylinder 26, a head limiting component, and a tail limiting component; the rotating component is connected to the detection stage 1; the limiting cylinder 26 is connected to the rotating component; the head limiting component and the tail limiting component are respectively installed on the rear and front sides of the limiting cylinder 26.

[0069] The limiting tube 26 is made of transparent material; the upper side of the limiting tube 26 is provided with a movable groove 27 to facilitate the passage of the mouse tail;

[0070] An adjustable lifting tail root fixation mechanism 3 for limiting the tail root of mice is installed on the front side of the testing table 1.

[0071] The adjustable lifting tail root fixing mechanism 3 includes a lifting component and a pressing component; the lifting component is installed in the middle of the front side of the inspection table 1; the pressing component is installed on the right side of the inspection table 1.

[0072] The follow-up tail tip fixing mechanism 4, used to limit the tail tip of mice and facilitate intravenous drug injection in mice, is connected to the lifting assembly.

[0073] The follow-up tail tip fixing mechanism 4 includes a one-way moving component, an arc-shaped placement plate 47, and a flip-pressing component; the one-way moving component is connected to the lifting component; the arc-shaped placement plate 47 is installed on the front side of the one-way moving component; the flip-pressing component is connected to the arc-shaped placement plate 47.

[0074] The arc-shaped placement plate 47 has a placement groove in the middle for placing the tip of the mouse tail;

[0075] A storage slot is provided on the right side of the testing table 1; several syringes 5 for injecting drugs into mice are placed in the storage slot.

[0076] In this invention, the tail limiting component is released from obstruction of the front side of the limiting cylinder 26. Then, the operator puts the head of the mouse to be tested into the limiting cylinder 26 from the front side. At this time, the mouse will crawl backward along the inner wall of the limiting cylinder 26. At this time, the operator holds the root of the mouse's tail with one hand and resets the tail limiting component to achieve the limitation of the mouse's tail. At this time, the mouse's tail is located in front of the limiting cylinder 26.

[0077] Then, pull the head limiting component forward along the limiting cylinder 26 until the mouse head is pressed against the head limiting component, thereby fixing the mouse body.

[0078] Subsequently, the rotating component controls the limiting cylinder 26 to rotate 90 degrees, so that the side of the mouse tail faces upward. Then, the lifting component moves upward to lift the base of the mouse tail from below, and the pressing component also presses down on the base of the mouse tail from above, ensuring that the base of the mouse tail is limited by the lifting component and the pressing component.

[0079] The one-way moving component moves upward along with the lifting component. After the limit at the base of the mouse tail is completed, the operator straightens the mouse tail and pulls the one-way moving component forward a distance according to the length of the mouse tail until the arc-shaped placement plate 47 installed on the one-way moving component is aligned with the tip of the mouse tail.

[0080] Then, the flip-pressing component is rotated forward to place the mouse's tail in the placement slot on the arc-shaped placement plate 47. Then, the flip-pressing component is rotated back to its original position. Since the arc-shaped placement plate 47 is curved, the tip of the mouse's tail will remain curved under the pressure of the flip-pressing component, thus automatically pressing the tip of the mouse's tail. This avoids the operator having to press the tail tip with one hand during subsequent intravenous injection, which could cause deviation during needle insertion.

[0081] Finally, the operator takes out syringe 5 from the storage slot, draws up the drug to be tested, and pushes it backward along the flip-clamping assembly. The flip-clamping assembly can provide support for the outer shell of syringe 5 and also ensure that the needle of syringe 5 is aligned with the vein at the tip of the mouse's tail, thereby improving the accuracy of needle insertion.

[0082] Example 2: In some embodiments, such as Figures 1-10 As shown, in a preferred embodiment of the present invention, the rotating assembly includes a bracket 21, a rotating control motor 22, a rotating gear 23, a driven half-gear ring 24, a rotating mounting ring 25, and a partition ring 222; the bracket 21 is fixedly installed in the middle of the testing table 1; the rotating control motor 22 is fixedly installed in the rear end of the bracket 21; the rotating gear 23 is rotatably installed in the front end of the bracket 21; the output end of the rotating control motor 22 is fixedly connected to the rotating gear 23; a partition groove 221 is provided in the middle of the bracket 21; the partition ring 222 is slidably connected to the partition groove 221; the partition ring 222 is fixedly installed in the middle of the outer end of the rotating mounting ring 25.

[0083] Driven half-gear ring 24 is fixedly installed on the front side of the outer end of rotating mounting ring 25; rotating gear 23 is meshed with driven half-gear ring 24;

[0084] Both the bracket 21 and the rotating mounting ring 25 have movable grooves 27 on their upper sides to facilitate the passage of the mouse's tail;

[0085] The limiting sleeve 26 is fixedly installed in the middle of the rotating mounting ring 25;

[0086] The head limiting assembly includes a sleeve 28, a conical cylinder 29, a limiting roller 210, a first locking screw 211, and a first locking knob 212; the sleeve 28 is slidably connected to the inner wall of the limiting cylinder 26; the conical cylinder 29 is fixedly installed on the inner wall of the sleeve 28; the rear end of the conical cylinder 29 has a through hole to facilitate the mouse's breathing.

[0087] The limiting rollers 210 are rotatably mounted on the front and rear sides of the upper end of the sleeve 28; the first locking screw 211 is fixedly mounted in the middle of the upper end of the sleeve 28; the first locking knob 212 is threadedly connected to the first locking screw 211.

[0088] The tail limiting assembly includes a flip cover 213, a first reset torsion spring 214, a locking ear plate 215, a locking screw 216, a locking nut 217, a retaining ring 219, and a U-shaped limiting insert plate 220; the flip cover 213 is rotatably mounted on the front right side of the limiting cylinder 26; the first reset torsion spring 214 is wound around the connecting shaft between the flip cover 213 and the limiting cylinder 26; one end of the first reset torsion spring 214 is fixedly connected to the connecting shaft between the flip cover 213 and the limiting cylinder 26;

[0089] The other end of the first reset torsion spring 214 is fixedly connected to the limiting cylinder 26;

[0090] The first reset torsion spring 214 ensures that the flip cover 213 always has a tendency to rotate forward.

[0091] The locking ear plate 215 is fixedly installed on the front left side of the limiting cylinder 26;

[0092] Both the locking ear plate 215 and the flip cover 213 have insertion holes on their left sides; the locking screw 216 is inserted into the insertion hole, and the locking nut 217 is threadedly connected to the locking screw 216.

[0093] The insertion rings 219 are symmetrically fixedly installed on the upper and lower front sides of the flip cover 213; the U-shaped limiting plate 220 is inserted into the insertion rings 219;

[0094] The flip cover 213 has an arc-shaped groove 218 in the middle to facilitate the passage of a mouse's tail;

[0095] In this invention, the U-shaped limiting plate 220 is first pulled out from the insert ring 219, and then the locking nut 217 is continuously rotated until the locking nut 217 is separated from the locking screw 216. Then the locking screw 216 is pulled out from the insertion hole opened on the locking ear plate 215 and the flip cover 213, thereby releasing the limitation on the flip cover 213. At this time, the flip cover 213 will rotate forward under the restoring force of the first reset torsion spring 214, thereby releasing the obstruction on the front side of the limiting cylinder 26.

[0096] The mouse to be tested for drugs is then placed head-first into the front of the limiting cylinder 26. The mouse will then crawl backward along the inner wall of the limiting cylinder 26. At this point, the operator holds the base of the mouse's tail with one hand and pulls the flip cover 213 to rotate backward and reset it. During the rotation, the mouse's tail will be placed inside the arc-shaped groove 218 until the locking ear plate 215 is aligned with the flip cover 213 again. Then, the locking screw 216 is reinserted into the insertion hole, and the locking nut 217 is screwed into the locking screw 216 until the locking nut 217 is pressed against the bottom of the lower locking ear plate 215, thereby fixing the flip cover 213. At this point, the flip cover 213 will prevent the mouse from moving forward.

[0097] Then the U-shaped limiting plate 220 is inserted into the insertion ring 219. At this time, the two sides of the mouse's tail will be limited by the inner wall of the U-shaped limiting plate 220 and the right inner wall of the arc groove 218. The mouse's tail extends forward from the arc groove 218 and is located in front of the limiting cylinder 26.

[0098] Subsequently, pulling the first locking knob 212 causes the sleeve 28 to move backward along the moving groove 27 following the limiting roller 210 until the mouse's head is pressed against the front inner wall of the conical cylinder 29. Then, the first locking knob 212 is rotated so that the first locking knob 212 rotates downward along the first locking screw 211 until the lower end of the first locking knob 212 is pressed against the upper end of the limiting cylinder 26, thereby fixing the position of the sleeve 28. This completes the fixation of the mouse's body.

[0099] Subsequently, the rotary control motor 22 controls the rotary gear 23 to rotate, and the rotary gear 23 drives the driven half-tooth ring 24 to rotate, causing the rotating mounting ring 25 to follow the partition protrusion ring 222 to rotate 90 degrees along the partition slide groove 221, thereby causing the limiting cylinder 26 to rotate 90 degrees synchronously, so that the side of the mouse tail faces upward, and the U-shaped limiting plate 220 will slide along the insertion ring 219 towards the inner wall of the arc groove 218 under the action of self-locking gravity, further compressing the mouse tail, reducing the shaking of the mouse tail, and facilitating the subsequent intravenous injection operation of the mouse by the operator;

[0100] After the injection is completed, the rotary control motor 22 controls the limiting cylinder 26 to rotate and reset, pulls the U-shaped limiting plate 220 out of the insert ring 219, separates the locking nut 217 from the locking screw 216, and takes out the locking screw 216. Then the flip cover 213 rotates forward to reset and rotates the first locking knob 212 in the opposite direction to release the limitation of the sleeve 28. Then the first locking knob 212 is pulled to move backward, so that the sleeve 28 moves out from behind the limiting cylinder 26. Then the mouse tail is pulled out from above the moving slide 27 and the mouse is pulled to move backward along the inner wall of the limiting cylinder 26.

[0101] The lifting assembly includes a first U-shaped mounting plate 31, a lifting cylinder 32, a lifting guide rod 33, and a lifting plate 34; the first U-shaped mounting plate 31 is fixedly installed on the lower side of the testing table 1; the lifting cylinder 32 is fixedly installed in the lower middle part of the first U-shaped mounting plate 31; the lifting guide rod 33 is slidably connected to the first U-shaped mounting plate 31; the lifting plate 34 is fixedly connected to the output end of the lifting cylinder 32; the lifting plate 34 is also fixedly connected to the lifting guide rod 33.

[0102] The middle part of the lifting plate 34 is provided with a tail root receiving groove 35 for placing the tail root of a mouse;

[0103] The pressing assembly includes an L-shaped mounting plate 36, a flip control motor 37, and a straight pressure plate 38; the L-shaped mounting plate 36 is fixedly mounted on the upper right side of the testing table 1; the flip control motor 37 is fixedly mounted on the rear end of the L-shaped mounting plate 36; the straight pressure plate 38 is rotatably mounted on the front end of the L-shaped mounting plate 36; the output end of the flip control motor 37 is fixedly connected to the straight pressure plate 38.

[0104] A useful pressure groove 39 is also provided on the upper side of the tail root receiving groove 35;

[0105] The unidirectional moving component is connected to the lifting plate 34;

[0106] The unidirectional moving assembly includes a second U-shaped mounting plate 41, a second locking screw 42, a second locking knob 43, a pressure ring 44, and an adjusting plate 45; the second U-shaped mounting plate 41 is symmetrically fixedly installed on the left and right sides of the lifting plate 34;

[0107] The second locking screw 42 is symmetrically fixedly installed on the front and rear sides of the left end of the lifting plate 34;

[0108] The second locking knob 43 is threadedly connected to the second locking screw 42; the pressure ring 44 is fixedly installed on the right end of the second locking knob 43;

[0109] The adjusting plate 45 is slidably connected to the second U-shaped mounting plate 41; the middle part of the adjusting plate 45 is provided with an avoidance groove 46 to facilitate the passage of the second locking screw 42;

[0110] The arc-shaped placement plate 47 is fixedly connected to the left and right adjustment plates 45;

[0111] The flipping and pressing assembly includes an arc-shaped pressure plate 48, a second reset torsion spring 49, and a pressure roller 410; the arc-shaped pressure plate 48 is symmetrically rotated and installed on the left and right sides of the arc-shaped placement plate 47; the second reset torsion spring 49 is wound around the connecting shaft between the arc-shaped pressure plate 48 and the arc-shaped placement plate 47; one end of the second reset torsion spring 49 is fixedly connected to the connecting shaft between the arc-shaped pressure plate 48 and the arc-shaped placement plate 47; the other end of the second reset torsion spring 49 is fixedly connected to the arc-shaped placement plate 47.

[0112] The second reset torsion spring 49 ensures that the arc-shaped pressure plate 48 always tends to rotate upwards.

[0113] Two pressure rollers 410 are provided; and the pressure rollers 410 are rotatably mounted on the left and right arc-shaped pressure plates 48 via a damping shaft.

[0114] Furthermore, a contour groove 411 is provided in the middle of the upper pressure roller 410;

[0115] In this invention, the lifting cylinder 32 controls the lifting plate 34 to move upward following the lifting guide rod 33. During the movement, the tail root receiving groove 35 opened in the middle of the lifting plate 34 will lift the root of the mouse tail from below, and the flipping control motor 37 will also control the straight pressure plate 38 to rotate downward, so that the straight pressure plate 38 moves into the pressure groove 39. At this time, the mouse tail root will be limited by the lower end of the straight pressure plate 38 and the inner bottom of the tail root receiving groove 35.

[0116] When the lifting plate 34 moves upward, it will also drive the second U-shaped mounting plate 41, the adjusting plate 45 and the arc-shaped placement plate 47 to move upward. After the limit at the base of the mouse tail is completed, the operator straightens the mouse tail and, according to the length of the mouse tail, first rotates the second locking knob 43, so that the second locking knob 43 moves to the left along the second locking screw 42, thereby separating the pressure ring 44 from the left end of the left adjusting plate 45, thereby releasing the fixation of the position of the adjusting plate 45, and pulling the adjusting plate 45 forward along the inner wall of the second U-shaped mounting plate 41 until the arc-shaped placement plate 47 installed on the adjusting plate 45 is aligned with the tip of the mouse tail.

[0117] Then, the pressure roller 410 is pulled down to drive the arc-shaped pressure plate 48 to rotate downward around the hinge point with the arc-shaped placement plate 47, and place the mouse's tail tip in the placement groove opened on the arc-shaped placement plate 47. Then, under the restoring force of the second reset torsion spring 49, the arc-shaped pressure plate 48 rotates upward to reset. At this time, the pressure roller 410 will press the mouse's tail tip into the placement groove opened on the arc-shaped placement plate 47. Since the arc-shaped placement plate 47 is curved, the mouse's tail tip will remain curved under the pressure of the pressure roller 410, realizing automatic pressing of the mouse's tail tip. This avoids the operator having to press the tail tip with one hand when performing intravenous injection, which could cause deviation when inserting the needle.

[0118] Finally, the operator takes out the syringe 5 from the storage slot, draws the drug to be tested, controls the syringe 5 with both hands and places the outer end of the syringe 5 into the contour groove 411 opened on the upper pressure roller 410, and pushes it backward along the contour groove 411. The upper pressure roller 410 can provide support for the syringe 5 and also ensure that the needle of the syringe 5 is aligned with the vein at the tip of the mouse's tail, thereby ensuring the accuracy and stability of the needle insertion.

[0119] Example 3: In some embodiments, such as Figures 1-10 As shown, in a preferred embodiment of the present invention, a method of using a smart intravenous injection device for drug efficacy testing in mice includes the following steps:

[0120] Step 1: Remove the tail limiting component from the front of the limiting cylinder 26. Place the mouse to be tested with its head facing backward into the front of the limiting cylinder 26. The mouse will crawl backward along the inner wall of the limiting cylinder 26. The operator will hold the base of the mouse's tail with one hand and reset the tail limiting component to limit the mouse's tail.

[0121] Step 2: Pull the head limiting component forward along the limiting cylinder 26 until the mouse's head is pressed against the head limiting component, thereby fixing the mouse's body.

[0122] Step 3: The rotating component controls the limiting cylinder 26 to rotate 90 degrees, so that the side of the mouse tail faces upward. The lifting component moves upward to lift the base of the mouse tail from below, and the pressing component presses down on the base of the mouse tail from above, ensuring that the base of the mouse tail is limited by the lifting component and the pressing component.

[0123] Step 4: After the mouse tail base is positioned, the operator straightens the mouse tail and, based on the length of the mouse tail, pulls the one-way moving component forward a certain distance until the arc-shaped placement plate 47 installed on the one-way moving component is aligned with the tip of the mouse tail.

[0124] Step 5: Control the flip-pressing component to rotate forward, place the mouse's tail in the placement slot on the arc-shaped placement plate 47, and then control the flip-pressing component to rotate and reset, so as to automatically press the tip of the mouse's tail.

[0125] Step Six: The operator takes syringe 5 from the storage compartment, draws the drug to be tested, and then uses both hands to control the needle of syringe 5 to push it backward along the flip-pressing assembly into the vein at the tip of the mouse's tail to inject the drug.

[0126] The above embodiments are only used to illustrate the technical solutions of the present invention, and are not intended to limit it. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features. Such modifications or substitutions will not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A smart intravenous injection device for detecting drug efficacy in mice, comprising a detection platform (1) and a syringe (5), characterized in that: It also includes a rotating flip-top mouse fixation mechanism (2), an adjustable lifting tail root fixation mechanism (3), and a follow-up tail tip fixation mechanism (4). A rotating flip-top mouse restraint mechanism (2) for easy mouse fixation is installed in the middle of the testing table (1); The rotating flip-top mouse fixation mechanism (2) includes a rotating component, a limiting cylinder (26), a head limiting component, and a tail limiting component; the rotating component is connected to the testing platform (1); the limiting cylinder (26) is connected to the rotating component; the head limiting component and the tail limiting component are respectively installed on the rear and front sides of the limiting cylinder (26); A movable groove (27) is provided on the upper side of the limiting cylinder (26); An adjustable lifting tail root fixation mechanism (3) for limiting the tail root of mice is installed on the front side of the testing table (1); The adjustable lifting tail root fixing mechanism (3) includes a lifting component and a pressing component; the lifting component is installed in the middle of the front side of the testing table (1); the pressing component is installed on the right side of the testing table (1); The follow-up tail tip fixing mechanism (4) used to limit the tail tip of mice and facilitate intravenous drug injection in mice is connected to the lifting component; The testing station (1) has a storage slot on the right side; several syringes (5) for injecting drugs into mice are placed in the storage slot.

2. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 1, characterized in that, The follow-up tail tip fixing mechanism (4) includes a one-way moving component, an arc-shaped placement plate (47) and a flip-pressing component; the one-way moving component is connected to the lifting component; the arc-shaped placement plate (47) is installed on the front side of the one-way moving component; the flip-pressing component is connected to the arc-shaped placement plate (47).

3. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 2, characterized in that, The rotating assembly includes a bracket (21), a rotating control motor (22), a rotating gear (23), a driven half-gear ring (24), a rotating mounting ring (25), and a partition ring (222); the bracket (21) is fixedly installed in the middle of the testing table (1); the rotating control motor (22) is fixedly installed in the rear end of the bracket (21); the rotating gear (23) is rotatably installed in the front end of the bracket (21); the output end of the rotating control motor (22) is fixedly connected to the rotating gear (23); a partition groove (221) is provided in the middle of the bracket (21); the partition ring (222) is limited and slidably connected to the partition groove (221); the partition ring (222) is fixedly installed in the middle of the outer end of the rotating mounting ring (25); The driven half-gear ring (24) is fixedly installed on the front side of the outer end of the rotating mounting ring (25); the rotating gear (23) meshes with the driven half-gear ring (24); The upper side of both the bracket (21) and the rotating mounting ring (25) is provided with a sliding groove (27); The limiting cylinder (26) is fixedly installed in the middle of the rotating mounting ring (25).

4. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 3, characterized in that, The tail limiting assembly includes a flip cover (213), a first reset torsion spring (214), a locking ear plate (215), a locking screw (216), a locking nut (217), a plug ring (219), and a U-shaped limiting insert plate (220); the flip cover (213) is rotatably mounted on the front right side of the limiting cylinder (26); the first reset torsion spring (214) is wound around the connecting shaft between the flip cover (213) and the limiting cylinder (26); one end of the first reset torsion spring (214) is fixedly connected to the connecting shaft between the flip cover (213) and the limiting cylinder (26); The other end of the first reset torsion spring (214) is fixedly connected to the limiting cylinder (26); The first reset torsion spring (214) ensures that the flip cover (213) always tends to rotate forward. The locking ear plate (215) is fixedly installed on the front left side of the limiting cylinder (26); The left side of both the locking ear plate (215) and the flip cover (213) is provided with a socket; the locking screw (216) is inserted into the socket, and the locking nut (217) is threadedly connected to the locking screw (216); The insert ring (219) is symmetrically fixedly installed on the upper and lower front sides of the flip cover (213); the U-shaped limiting insert plate (220) is inserted into the insert ring (219); An arc-shaped groove (218) is provided in the middle of the flip cover (213).

5. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 4, characterized in that, The lifting assembly includes a first U-shaped mounting plate (31), a lifting cylinder (32), a lifting guide rod (33), and a lifting plate (34); the first U-shaped mounting plate (31) is fixedly installed on the lower side of the testing table (1); the lifting cylinder (32) is fixedly installed in the middle of the lower end of the first U-shaped mounting plate (31); the lifting guide rod (33) is slidably connected to the first U-shaped mounting plate (31); the lifting plate (34) is fixedly connected to the output end of the lifting cylinder (32); the lifting plate (34) is also fixedly connected to the lifting guide rod (33); The lifting plate (34) has a tail root receiving groove (35) in the middle.

6. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 5, characterized in that, The unidirectional moving assembly includes a second U-shaped mounting plate (41), a second locking screw (42), a second locking knob (43), a pressure ring (44), and an adjusting plate (45); the second U-shaped mounting plate (41) is symmetrically fixed on the left and right sides of the lifting plate (34); The second locking screw (42) is symmetrically fixed on the front and rear sides of the left end of the lifting plate (34); The second locking knob (43) is threadedly connected to the second locking screw (42); the pressure ring (44) is fixedly installed on the right end of the second locking knob (43); The adjusting plate (45) is in a limited sliding connection with the second U-shaped mounting plate (41); The arc-shaped placement plate (47) is fixedly connected to the left and right adjustment plates (45).

7. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 6, characterized in that, An obstacle avoidance groove (46) is provided in the middle of the adjusting plate (45).

8. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 6, characterized in that, The flipping and pressing assembly includes an arc-shaped pressure plate (48), a second reset torsion spring (49), and a pressure roller (410); the arc-shaped pressure plate (48) is symmetrically rotated and installed on the left and right sides of the arc-shaped placement plate (47); the second reset torsion spring (49) is wound around the connecting shaft between the arc-shaped pressure plate (48) and the arc-shaped placement plate (47); one end of the second reset torsion spring (49) is fixedly connected to the connecting shaft between the arc-shaped pressure plate (48) and the arc-shaped placement plate (47); the other end of the second reset torsion spring (49) is fixedly connected to the arc-shaped placement plate (47); Two pressure rollers (410) are provided; and the pressure rollers (410) are rotatably mounted on the left and right arc-shaped pressure plates (48) via a damping shaft; Furthermore, a contour groove (411) is provided in the middle of the upper pressure roller (410).

9. The intelligent intravenous injection device for drug efficacy testing in mice according to claim 8, characterized in that, The second reset torsion spring (49) ensures that the arc-shaped pressure plate (48) always tends to rotate upward.

10. A method of use, utilizing the intelligent intravenous injection device for detecting drug efficacy in mice as described in claim 2, characterized in that, Includes the following steps: Step 1: Remove the tail limiting component from the front of the limiting cylinder (26), and put the mouse whose head needs to be tested into the limiting cylinder (26) from the front. The mouse crawls backward along the inner wall of the limiting cylinder (26). The operator holds the root of the mouse's tail with one hand and resets the tail limiting component to limit the tail of the mouse. Step 2: Pull the head limiting component forward along the limiting cylinder (26) until the mouse head is pressed against the head limiting component, thereby fixing the mouse body; Step 3: The rotating component controls the limiting cylinder (26) to rotate 90 degrees so that the side of the mouse tail faces upward. The lifting component moves upward to lift the root of the mouse tail from below, and the pressing component presses down on the root of the mouse tail from above, ensuring that the root of the mouse tail is limited by the lifting component and the pressing component. Step 4: After the mouse tail base is positioned, the operator straightens the mouse tail and, according to the length of the mouse tail, pulls the one-way moving component forward a certain distance until the arc-shaped placement plate (47) installed on the one-way moving component is aligned with the tip of the mouse tail. Step 5: Control the flip-pressing component to rotate forward, place the mouse's tail in the placement slot opened on the arc-shaped placement plate (47), and then control the flip-pressing component to rotate and reset, so as to automatically press the tip of the mouse's tail. Step 6: The operator takes out the syringe (5) from the storage slot, draws the drug to be tested, and then uses both hands to control the needle of the syringe (5) to push it backward along the flip-pressing assembly into the vein at the tip of the mouse's tail to inject the drug.

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