A composition with whitening and soothing effects, preparation method and application

Abstract

The present application belongs to the technical field of cosmetics, and particularly relates to a composition with whitening and soothing effects, a preparation method and application. The composition is a hydrogel-liposome dispersion composite system, and according to 100 parts of total weight, the composition comprises 10-15 parts of a high liquid-loading hydrogel matrix, 5-10 parts of whitening-soothing liposomes, and the rest is solvent; the high liquid-loading hydrogel matrix comprises a structured composite gelling agent and a humectant, the composite gel is composed of carboxymethyl available gelatin, silk peptide and sodium hyaluronate, the weight average molecular weight of the sodium hyaluronate is 800k-1200kDa; the whitening-soothing liposomes comprise a membrane material system and cosmetic active ingredients, the membrane material system is composed of soybean lecithin, cholesterol and an emulsifier, and the emulsifier is composed of mannose erythritol lipid and rhamnolipid. The composition prepared by the present application has good stability and good whitening and soothing effects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a composition, preparation method and application with whitening and soothing effects. Background Technology

[0002] Whitening masks, as a mainstream product in the cosmetics industry for achieving skin whitening and improving dull skin tone, have seen continuous growth in market demand in recent years. In particular, gentle whitening and soothing repair masks for sensitive skin have become a key focus of industry research and development. However, existing whitening masks face multiple technical bottlenecks in terms of ingredient stability, efficacy compatibility, carrier capacity, and safety of use, which seriously restrict the effectiveness of these products.

[0003] Firstly, whitening and soothing active ingredients suffer from poor stability, incompatibility, and a tendency to irritate sensitive skin. Commonly used whitening active ingredients in current face masks, such as vitamin C derivatives and arbutin, are chemically unstable and easily deactivated by external factors like light, oxidation, and temperature, leading to a decrease in whitening efficacy. Furthermore, these ingredients are highly irritating when in direct contact with the skin, easily causing discomfort such as redness, stinging, and burning in sensitive skin. On the other hand, soothing and repairing ingredients like panthenol and asiaticoside, due to significant differences in polarity and solubility, are prone to incompatibility issues such as layering, crystallization, and antagonistic effects in formulations, failing to achieve a synergistic effect of whitening and soothing, and thus failing to meet the core need of sensitive skin for "gentle whitening and simultaneous repair."

[0004] Secondly, conventional liposome carriers lack precise structural design, resulting in insufficient encapsulation and stability. While liposomes, as carriers of active ingredients, can improve ingredient stability and skin permeability, commercially available and existing technologies do not precisely define the composition, ratio, and encapsulation parameters of the membrane material. This leads to defects such as low encapsulation efficiency (usually below 75%), uneven particle size distribution, and poor colloidal stability. When combined with hydrogel matrices, they are prone to aggregation, sedimentation, and stratification, failing to achieve stable carrying and controlled sustained release of active ingredients, ultimately significantly reducing the efficacy of the mask.

[0005] Third, traditional hydrogel gelling agents lack key structural parameters, resulting in poor liquid carrying capacity and mechanical properties. Existing hydrogel masks often use natural gelling agents such as konjac gum and acacia gum, but these are only vaguely labeled with the raw material names, without specifying core structural parameters such as functional group substitution degree, monomer molar ratio, carboxyl / hydroxyl group density, and viscosity characteristics. This leads to a loose and disordered cross-linked network in the hydrogel formation, resulting in extremely low liquid carrying capacity (only 5-10 times its own weight) and limited essence-carrying capacity. Simultaneously, the gel exhibits poor mechanical properties and poor adherence, failing to restrict liposome migration through its network structure, making it difficult to achieve long-lasting sustained release of active ingredients and providing gentle, long-lasting care for sensitive skin.

[0006] In summary, existing whitening mask technologies cannot simultaneously solve technical problems such as the compatibility and stability of active ingredients, the stability of liposomes and gels, and the more significant improvement in whitening and soothing effects. Summary of the Invention

[0007] The purpose of this invention is to provide a facial mask composition loaded with whitening and soothing dual-effect liposomes and related technologies, so as to prepare a facial mask with stable and compatible active ingredients, efficient liposome encapsulation, high hydrogel loading and sustained release, and better whitening and soothing effects than existing facial masks.

[0008] To achieve the above-mentioned objectives, in a first aspect, the present invention provides a composition with whitening and soothing effects, characterized in that the composition is a hydrogel-liposome dispersion composite system, comprising 10-15 parts of a high-load hydrogel matrix, 5-10 parts of whitening-soothing liposomes, and the remainder being a solvent, based on a total weight of 100 parts. The high-fluid-carrying hydrogel matrix includes a structured composite gelling agent and a humectant. The structured composite gelling agent is composed of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate. The whitening-soothing liposome comprises a membrane system and cosmetic active ingredients. The membrane system consists of soybean lecithin, cholesterol, and an emulsifier, which is composed of mannose erythritol ester and rhamnolipid.

[0009] Preferably, the mass ratio of soybean lecithin, cholesterol, and emulsifier is 1-5:0.3-1.5:0.1-0.5.

[0010] Preferably, the mass ratio of mannose erythritol ester to rhamnolipoester is 1-3:1.

[0011] Preferably, the mass ratio of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate is 3-9:1-3:2-5.

[0012] Preferably, the composition further includes 0.1-0.5 parts of a pH adjuster and 0.1-0.6 parts of a preservative.

[0013] Preferably, the moisturizer is at least one of glycerin and polyethylene glycol, and / or the pH adjuster is a citric acid / sodium citrate buffer pair, and / or the preservative is phenoxyethanol, the solvent is water, and the cosmetic active ingredient includes vitamin C and arbutin.

[0014] Preferably, the mass ratio of the structured composite gelling agent to the moisturizer is 1:1-2; and / or the mass ratio of the membrane system to the cosmetic active ingredient is 1-3:1.

[0015] Preferably, the sodium hyaluronate has a weight-average molecular weight of 800k-1200kDa.

[0016] Secondly, the present invention provides a method for preparing the composition, comprising the following steps: S1. Mix carboxymethyl guar gum, silk fibroin peptide, sodium hyaluronate and humectant, stir, add half of the solvent to swell, mix well, and obtain hydrogel precursor solution. S2. Dissolve soybean lecithin and cholesterol in ethanol to obtain a membrane material solution; mix the cosmetic active ingredients with the remaining solvent, and sonicate to obtain a core material suspension; S3. The membrane solution obtained in step S2 is rotary evaporated to form a lipid film. The core material suspension is added, the film is swollen, sonicated, and filtered to obtain liposomes. S4. Mix the liposomes with the hydrogel precursor solution, stir, add a pH adjuster to adjust the pH value to 5.5-6.0, add preservatives and the remaining water, and mix to obtain the final product.

[0017] Thirdly, the present invention provides a hydrogel face mask made from the aforementioned composition.

[0018] Fourthly, the present invention provides the use of the described composition in the preparation of cosmetics.

[0019] Compared with the prior art, the present invention has at least the following beneficial effects: (1) In the composite gelling agent of the present invention, carboxymethyl guar gum provides a triple helix rigid gel skeleton, silk fibroin peptides provide flexible cross-linking points and cell adhesion, and sodium hyaluronate provides hydrophilic filling and water retention capacity. When combined, they form a three-dimensional network structure with excellent mechanical properties and biological activity, achieving the best balance in whitening, soothing and stability.

[0020] (2) In the liposome emulsifier of the present invention, mannose erythritol liposome has a ceramide-like spatial structure and a mild skin feel; rhamnoliposome has a suitable HLB value and good interfacial activity. When the two are compounded in a mass ratio of 1-3:1, they can form a complementary arrangement at the interface of the liposome bilayer, reduce the interfacial tension and improve the density of the membrane material, thereby improving the storage stability of the liposome and ultimately promoting the efficient delivery and efficacy of the active ingredients.

[0021] (3) The mask composition loaded with whitening and soothing dual-effect liposomes prepared in this invention has good stability. It can be stored in the dark for 6 months at 40℃±0.5℃ / RH 75%±3%. No phase separation was observed in the examples. After 3 freeze-thaw cycles, the gel was intact and dense, without demulsification or water separation, and the elasticity recovery rate was ≥96%.

[0022] (4) This invention was verified by tyrosinase activity inhibition experiments. The tyrosinase inhibition rate of this invention is as high as 82.3%, IC50. 50The concentration was 0.87 mg / mL. Hyaluronidase inhibition experiments verified that the hyaluronidase inhibition rate of this invention was as high as 78.5%, even superior to the positive control ascorbic acid (VC, 40 μg / mL), demonstrating excellent whitening and soothing effects. Detailed Implementation

[0023] Terminology and Declarations of this Invention: 1. Articles “a,” “a kind,” and “the”: These include plural objects unless otherwise explicitly specified as a single (kind) object.

[0024] 2. Numerical Range: Unless otherwise expressly stated, all ranges or ratios disclosed herein shall be construed as including any and all subranges or subratios contained herein. For example, a stated range or ratio of 1 to 30 shall be considered to be included between the minimum value of 1 and the maximum value of 30, and includes any subranges or subratios, integers, decimals, or subranges or subratios consisting of integers or decimals, including endpoints.

[0025] The following non-limiting embodiments are intended to enable those skilled in the art to more fully understand the present invention, but are not intended to limit the invention in any way.

[0026] The following content is merely an exemplary description of the scope of protection of this invention. Those skilled in the art can make various changes and modifications to this invention based on the disclosed content, and such changes should also fall within the scope of protection of this invention.

[0027] The present invention will be further described below by way of specific embodiments. Unless otherwise specified, all chemical reagents used in the embodiments of the present invention were obtained through conventional commercial means. Unless otherwise specified, all contents mentioned below are mass contents. Unless otherwise specified, it is understood that the process was carried out at room temperature (20-25°C).

[0028] The supplier of silk fibroin peptides is Wuhan Kemike Biomedical Technology Co., Ltd., with a purity of 99%. The supplier of carboxymethyl chloroform gum is Nanjing Beiyu Biotechnology Co., Ltd., and the product number is [product number missing]. MZBY-P-CMCUR.

[0029] The suppliers of sodium hyaluronate of different molecular weights are all Yulin Runtianchang Chemical Co., Ltd.

[0030] The supplier of mannose erythritol ester is Hubei Science Chemical Co., Ltd., with a purity of 99%.

[0031] The supplier of rhamnolipin is Shaanxi Delevit Biotechnology Co., Ltd., and its purity is 95%.

[0032] Example 1 A composition with whitening and soothing effects, with components as shown in Table 1 below, based on a total weight of 100 parts.

[0033] Table 1

[0034] The high-load hydrogel matrix is ​​composed of a structured composite gelling agent and a humectant in a mass ratio of 1:1; the structured composite gelling agent is composed of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate in a mass ratio of 3:1:2; and the humectant is glycerin.

[0035] The whitening-soothing liposome is composed of a membrane material system and cosmetic active ingredients in a 1:1 mass ratio; in the membrane material system, the mass ratio of soybean lecithin, cholesterol, and emulsifier is 1:0.3:0.1; the emulsifier is composed of mannose erythritol ester and rhamnolipid in a 1:1 mass ratio; the cosmetic active ingredients are vitamin C and arbutin in a 1:1 mass ratio.

[0036] The sodium hyaluronate has a weight-average molecular weight of 800 kDa.

[0037] Preparation method: S1. Mix carboxymethyl guar gum, silk fibroin peptide, sodium hyaluronate and humectant (glycerin) according to the specified ratio, stir and disperse evenly, add half of the total amount of water, swell at room temperature for 12 hours, stir evenly, and obtain hydrogel precursor solution.

[0038] S2. Dissolve soybean lecithin and cholesterol in ethanol to obtain a membrane material solution; mix vitamin C, arbutin and water, and sonicate for 10 minutes to obtain a core material suspension.

[0039] S3. The membrane solution obtained in step S2 is rotary evaporated at 40°C to form a lipid film. The core material suspension is added, and the solution is swollen in a water bath at 40°C for 30 minutes. After ultrasonic treatment for 5 minutes, the solution is filtered through a 0.22μm filter membrane to obtain liposomes.

[0040] S4. Mix the liposomes with the hydrogel precursor solution and stir for 20 minutes. Add citric acid / sodium citrate buffer to adjust the pH to 5.5. Add phenoxyethanol and the remaining water and mix well to obtain the final product.

[0041] Example 2 A composition with whitening and soothing effects, with components listed in Table 2 below, based on a total weight of 100 parts.

[0042] Table 2

[0043] The high-load hydrogel matrix is ​​composed of a structured composite gelling agent and a humectant in a mass ratio of 1:1.5; the structured composite gelling agent is composed of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate in a mass ratio of 6:1:3; and the humectant is glycerin.

[0044] The whitening-soothing liposome is composed of a membrane material system and cosmetic active ingredients in a mass ratio of 2:1; in the membrane material system, the mass ratio of soybean lecithin, cholesterol, and emulsifier is 3:1:0.2; the emulsifier is composed of mannoerythritol ester and rhamnolipid in a mass ratio of 2:1; the cosmetic active ingredient is composed of vitamin C and arbutin in a mass ratio of 1:1.

[0045] The sodium hyaluronate has a weight-average molecular weight of 1000 kDa.

[0046] Preparation method: S1. Mix carboxymethyl guar gum, silk fibroin peptide, sodium hyaluronate and humectant (glycerin) according to the specified ratio, stir and disperse evenly, add half of the total amount of water, swell at room temperature for 15 hours, stir evenly, and obtain hydrogel precursor solution.

[0047] S2. Dissolve soybean lecithin and cholesterol in ethanol to obtain a membrane material solution; mix vitamin C, arbutin and water, and sonicate for 15 minutes to obtain a core material suspension.

[0048] S3. The membrane solution obtained in step S2 is rotary evaporated at 42°C to form a lipid film. The core material suspension is added, and the solution is swollen in a water bath at 42°C for 40 minutes. After ultrasonic treatment for 8 minutes, the solution is filtered through a 0.22μm filter membrane to obtain liposomes.

[0049] S4. Mix the liposomes with the hydrogel precursor solution and stir for 30 minutes. Add citric acid / sodium citrate buffer to adjust the pH to 5.8. Add phenoxyethanol and the remaining water and mix well to obtain the final product.

[0050] Example 3 A composition with whitening and soothing effects, with components listed in Table 3 below, based on a total weight of 100 parts.

[0051] Table 3

[0052] The high-load hydrogel matrix is ​​composed of a structured composite gelling agent and a humectant in a mass ratio of 1:2; the structured composite gelling agent is composed of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate in a mass ratio of 9:3:5; and the humectant is glycerin.

[0053] The whitening-soothing liposome is composed of a membrane material system and cosmetic active ingredients in a mass ratio of 3:1; in the membrane material system, the mass ratio of soybean lecithin, cholesterol, and emulsifier is 5:1.5:0.5; the emulsifier is composed of mannose erythritol ester and rhamnolipid in a mass ratio of 3:1; the cosmetic active ingredients are vitamin C and arbutin in a mass ratio of 1:1.

[0054] The sodium hyaluronate has a weight-average molecular weight of 1200 kDa.

[0055] Preparation method: S1. Mix carboxymethyl guar gum, silk fibroin peptide, sodium hyaluronate and humectant (glycerin) according to the specified ratio, stir and disperse evenly, add half of the total amount of water, swell at room temperature for 18 hours, stir evenly, and obtain hydrogel precursor solution.

[0056] S2. Dissolve soybean lecithin and cholesterol in ethanol to obtain a membrane material solution; mix vitamin C, arbutin and water, and sonicate for 20 minutes to obtain a core material suspension.

[0057] S3. The membrane solution obtained in step S2 is rotary evaporated at 45°C to form a lipid film. The core material suspension is added, and the solution is swollen in a water bath at 45°C for 50 minutes. After ultrasonic treatment for 10 minutes, the solution is filtered through a 0.22μm filter membrane to obtain liposomes.

[0058] S4. Mix the liposomes with the hydrogel precursor solution and stir for 40 minutes. Add citric acid / sodium citrate buffer to adjust the pH to 6.0. Add phenoxyethanol and the remaining water and mix well to obtain the final product.

[0059] Comparative Example 1 The only difference between this comparative example and Example 1 is that carboxymethyl guar gum is replaced with carbomer.

[0060] Comparative Example 2 The only difference between this comparative example and Example 1 is that the silk fibroin peptide is removed. The structured composite gelling agent is composed of carboxymethyl guar gum and sodium hyaluronate in a mass ratio of 4:2, and the total mass of the structured composite gelling agent is the same as that in Example 1.

[0061] Comparative Example 3 The only difference between this comparative example and Example 1 is that carboxymethyl chloroform gum is removed. The structured composite gelling agent is composed of silk fibroin peptide and sodium hyaluronate in a mass ratio of 4:2, and the total mass of the structured composite gelling agent is the same as that in Example 1.

[0062] Comparative Example 4 The only difference between this comparative example and Example 1 is that the emulsifier used is mannose erythritol ester, and the total amount of emulsifier used is the same as in Example 1.

[0063] Comparative Example 5 The only difference between this comparative example and Example 1 is that the emulsifier used is rhamnolipid, and the total amount of emulsifier used is the same as in Example 1.

[0064] Comparative Example 6 The only difference between this comparative example and Example 1 is that rhamnolipid is replaced with sophorolipid.

[0065] Comparative Example 7 The only difference between this comparative example and Example 1 is that the molecular weight of sodium hyaluronate is different, specifically 45 kDa.

[0066] Comparative Example 8 The only difference between this comparative example and Example 1 is that the molecular weight of sodium hyaluronate is different, specifically 1500 kDa.

[0067] Stability of Test Example 1 Centrifugation stability: Use a benchtop high-speed centrifuge at 3000 rpm and 25°C for 10 min to observe the volume ratio of the supernatant and the precipitation state.

[0068] Accelerated testing: Store in a constant temperature and humidity chamber at 40℃±0.5℃ / RH75%±3%, protected from light; high temperature / low temperature tests were conducted at 45℃ / 4℃ for 5 days and 10 days respectively, followed by centrifugal stability testing.

[0069] Centrifugation stability criteria: Centrifuge at 3000 rpm for 10 min. A supernatant volume ≤0.5% indicates stability (no phase separation), 0.5%-1.5% indicates basic stability, and >1.5% indicates obvious water separation or stratification.

[0070] Freeze-thaw cycles: -18℃ (24h) to 25℃ (24h) constitutes one cycle, for a total of 3 cycles; observe gel collapse, liposome demulsification, and centrifugation precipitation. Elastic recovery rate = (gel rebound height after freeze-thaw / initial height) × 100%.

[0071] The centrifugal stability results are shown in Table 4, and the stability results after freeze-thaw cycles are shown in Table 5.

[0072] Table 4

[0073] Table 5

[0074] As shown in Tables 4 and 5, Examples 1 and 3, under high temperature, low temperature, accelerated stability testing conditions, and after freeze-thaw cycles, showed no phase separation in centrifugation tests, and a freeze-thaw elastic recovery rate ≥96%, exhibiting excellent physicochemical stability. This fully demonstrates that this application, through a specific ratio of carboxymethyl guar gum, silk fibroin peptides, and sodium hyaluronate, combined with a dual-effect carrier of soybean lecithin / cholesterol liposomes and a buffer-moisturizing synergistic system, achieves thermodynamic compatibility between the three-dimensional hydrogel network and the liposome dispersion phase, overcoming the technical bottlenecks of traditional mask compositions that are prone to water seepage, layering, and active ingredient leakage under long-term storage or temperature fluctuations.

[0075] Test Example 2: Evaluation of Whitening Efficacy – Tyrosinase Activity Inhibition Experiment I. Experimental Basis Refer to the group standard T / SHRH 015-2018 "Cosmetics - Test Method for Inhibition of Tyrosinase Activity". This method is applicable to the efficacy evaluation of raw materials or compositions that claim to achieve whitening effects by inhibiting tyrosinase activity.

[0076] II. Experimental Principle Tyrosinase is a key rate-limiting enzyme in melanin synthesis. In melanin biosynthesis, tyrosinase catalyzes the oxidation of L-DOPA to dopaquinone, which has a characteristic absorption peak at 475 nm. When a sample inhibits tyrosinase activity, it reduces the conversion of L-DOPA to dopaquinone, thereby lowering the absorbance at 475 nm. By measuring the change in absorbance, the inhibition rate of tyrosinase activity by the sample can be calculated.

[0077] III. Experimental Materials and Reagents Table 6

[0078] IV. Experimental Procedure 1. Sample pretreatment The samples from Examples 1, 3 and each comparative example were prepared into a series of concentration gradients (e.g., 0.1, 0.5, 1.0, 2.0, 5.0 mg / mL) using sodium phosphate buffer (1 / 15 M, pH 6.8).

[0079] 2. Sample addition and reaction Add the components according to the system in Table 7 below: Table 7

[0080] After incubating at 30°C in a water bath for 10 min, L-DOPA solution was added, and incubation continued at 30°C for another 20 min. Immediately after the reaction was completed, the absorbance of each group was measured at a wavelength of 475 nm.

[0081] 3. Positive control Kojic acid was used as a positive control.

[0082] 4. Parallelism requirement Three parallel tubes were used for each sample, and the average value was taken.

[0083] V. Calculation of Results Tyrosinase inhibition rate (%) is calculated using the following formula: Inhibition rate (%) = [1 (A) 样品 A 样品空白 ) / (A 阴性对照 A 空白对照 )]×100% in: A 样品 : Absorbance values ​​of the sample group; A 样品空白 : Absorbance values ​​of the blank sample group; A 阴性对照 : Absorbance value of the negative control group; A 空白对照 : Absorbance value of blank control group.

[0084] VI. Experimental Results The inhibition rates of tyrosinase activity for each sample at a concentration of 2.0 mg / mL are shown in Table 8 below: Table 8

[0085] Note: The SD values ​​between all parallel tubes are ≤10%, which meets the requirements for effective parallelism of the test.

[0086] VII. Results Analysis Examples 1 and 3 are significantly superior to other comparative examples, indicating that the combination of carboxymethyl guar gum, silk fibroin peptide, and sodium hyaluronate has the best inhibitory effect on tyrosinase activity.

[0087] The inhibition rates of Comparative Examples 1-3 were significantly lower than those of Examples 1-3, demonstrating that the composite gel matrix of the present invention significantly improves the release of active ingredients, thereby exerting a whitening effect. Examples 1 and 3 showed significantly better inhibition rates than single emulsifiers or alternative sophoryl ester solutions, proving that the encapsulation and protection of active ingredients by the emulsifier complex directly affects the whitening effect.

[0088] Experiment 3: Evaluation of Soothing Efficacy – Hyaluronidase Inhibition Experiment I. Experimental Basis T / SHRH 015-2018 Cosmetics - Experimental Method for Inhibition of Tyrosinase Activity

[0089] The method is based on a hyaluronidase inhibition assay, which assesses the soothing efficacy of the sample by measuring changes in the absorbance of the reaction products.

[0090] II. Experimental Principle Hyaluronic acid (HA) is the most abundant component of the extracellular matrix and plays a vital role in maintaining skin hydration, elasticity, and wound healing. Hyaluronidase (HAase) is a specific lysin that breaks down hyaluronic acid, damaging it and disrupting the skin barrier. Inhibiting hyaluronidase activity ensures normal hyaluronic acid content and function. Therefore, a higher hyaluronidase inhibition rate indicates stronger soothing and anti-allergic activity in the sample. When the inhibition rate of the test sample is significantly higher than that of the negative control (P<0.05), the sample can be considered to have soothing effects.

[0091] III. Experimental Materials and Reagents Table 9

[0092] IV. Experimental Procedure 1. Sample pretreatment The samples from Examples 1, 3, and each comparative example were prepared with deionized water to a test concentration of 20 mg / mL.

[0093] 2. Sample addition and reaction Table 10

[0094] Incubate at 37°C in a water bath for 30 minutes to allow the enzyme to fully interact with the sample. Then add sodium hyaluronate solution and continue incubation at 37°C for 15 minutes.

[0095] 3. Color reaction After the reaction was complete, acetylacetone solution and DMAB solution were added, and the mixture was heated in a boiling water bath for 10 min. After cooling, the absorbance was measured at 520 nm.

[0096] 4. Positive control Ascorbic acid (VC, 40 μg / mL) was used as a positive control.

[0097] 5. Parallelism requirement Three parallel tubes were used for each sample, and the average value was taken as the test result.

[0098] V. Calculation of Results The hyaluronidase inhibition rate (%) was calculated based on the absorbance of the following samples:

[0099] VI. Experimental Results The hyaluronidase inhibition rates of each example and comparative sample at a concentration of 20 mg / mL are shown in Table 11 below: Table 11

[0100] VII. Results Analysis The high hyaluronidase inhibition rates in Examples 1 and 3 indicate that the composition has excellent soothing effects.

[0101] Comparative Example 3 (lacking carboxymethyl cordanum) showed an inhibition rate of only 28.9%, with P>0.05, indicating no significant difference. This demonstrates that carboxymethyl cordanum is the core framework for constructing the hydrogel network and ensuring the stable release of active ingredients, thus exerting a soothing effect. Comparative Example 1 (carbomer substitution) showed an inhibition rate of only 35.2%, demonstrating that although carbomer can form a gel, it cannot replace the synergistic effect of carboxymethyl cordanum in the soothing effect. Comparative Example 2 (lacking silk fibroin peptides) showed an inhibition rate of 42.6%, significantly lower than the examples, demonstrating that silk fibroin peptides make an indispensable contribution to the soothing effect. Comparative Examples 4-6 showed that the examples combining mannose erythritol ester and rhamnolipid showed significantly better hyaluronidase inhibition rates than single emulsifiers or sophorose ester substitutions, further demonstrating that the emulsifier combination enhances the soothing effect.

[0102] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A composition having whitening and soothing effects, characterized in that, The composition is a hydrogel-liposome dispersion composite system, comprising 10-15 parts of high-load hydrogel matrix, 5-10 parts of whitening-soothing liposomes, and the remainder being solvent, based on a total weight of 100 parts. The high-fluid-carrying hydrogel matrix includes a structured composite gelling agent and a humectant. The structured composite gelling agent is composed of carboxymethyl guar gum, silk fibroin peptide and sodium hyaluronate. The whitening-soothing liposome comprises a membrane system and cosmetic active ingredients. The membrane system consists of soybean lecithin, cholesterol, and an emulsifier, which is composed of mannose erythritol ester and rhamnolipid.

2. The composition according to claim 1, characterized in that, The mass ratio of soybean lecithin, cholesterol, and emulsifier is 1-5:0.3-1.5:0.1-0.

5.

3. The composition according to claim 1, characterized in that, The mass ratio of mannose erythritol ester to rhamnolipoester is 1-3:

1.

4. The composition according to claim 1, characterized in that, The mass ratio of carboxymethyl guar gum, silk fibroin peptide, and sodium hyaluronate is 3-9:1-3:2-5.

5. The composition according to claim 1, characterized in that, The composition further includes 0.1-0.5 parts of a pH adjuster and 0.1-0.6 parts of a preservative.

6. The composition according to claim 5, characterized in that, The moisturizer is at least one of glycerin and polyethylene glycol, and / or the pH adjuster is a citric acid / sodium citrate buffer pair, and / or the preservative is phenoxyethanol, the solvent is water, and the cosmetic active ingredients include vitamin C and arbutin.

7. The composition according to claim 6, characterized in that, The mass ratio of the structured composite gelling agent to the moisturizer is 1:1-2; and / or the mass ratio of the membrane system to the cosmetic active ingredient is 1-3:1; And / or, the weight-average molecular weight of the sodium hyaluronate is 800k-1200kDa.

8. A method for preparing the composition according to any one of claims 1-7, characterized in that, Includes the following steps: S1. Mix carboxymethyl guar gum, silk fibroin peptide, sodium hyaluronate and humectant, stir, add half of the water to swell, mix well, and obtain hydrogel precursor solution. S2. Dissolve soybean lecithin and cholesterol in ethanol to obtain a membrane material solution; mix the cosmetic active ingredients with the remaining water, and sonicate to obtain a core material suspension; S3. The membrane solution obtained in step S2 is rotary evaporated to form a lipid film. The core material suspension is added, the film is swollen, sonicated, and filtered to obtain liposomes. S4. Mix the liposomes with the hydrogel precursor solution, stir, add a pH adjuster to adjust the pH value to 5.5-6.0, add preservatives and the remaining water, and mix to obtain the final product.

9. A hydrogel face mask, characterized in that, Made from the composition according to any one of claims 1-7.

10. The use of the composition according to any one of claims 1-7 in the preparation of cosmetics with whitening and soothing effects.

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