A whitening composition for regulating the spatial distribution of melanin to improve the optical uniformity of skin and application thereof

Abstract

The present application relates to a whitening composition for regulating melanin spatial distribution and improving skin optical uniformity and its application, which comprises the following ingredients in the weight percentage: a complex of 0.5-3 parts of bisabolol and ginger root extract, 0.5-3 parts of potassium methoxysalicylate, 0.01-0.5 parts of hydrolyzed vegetable protein, and 0.05-0.2 parts of grape seed extract. The whitening composition provided in the present application can regulate melanin spatial distribution and improve skin optical uniformity by regulating the biological process related to melanin in the skin and the spatial distribution state thereof, thereby alleviating uneven skin color and dullness. The present application first constructs a technical solution different from the traditional "melanin suppression whitening" from the perspective of melanin distribution regulation and skin optical uniformity improvement. On the premise of effectively reducing the total amount of melanin, the uneven skin color and dull appearance are further improved.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products technology, and in particular relates to a whitening composition that regulates the spatial distribution of melanin and improves the optical uniformity of the skin and its application. Background Technology

[0002] The apparent color of the skin is determined by its optical properties, including absorption, scattering, and reflection of visible light. Melanin and hemoglobin are the main chromophores influencing the skin's optical behavior. Melanin, especially eumelanin, has a broad-spectrum absorption characteristic for visible light in the skin and is a key factor in determining the overall brightness and light protection ability of the skin. The formation, transport, distribution, and clearance of melanin all significantly affect the skin's optical performance.

[0003] Existing research indicates that abnormal skin color is not entirely equivalent to an increase in total melanin. Under physiological or pathological conditions such as inflammation, oxidative stress, or abnormal keratin turnover, melanin in the skin may exhibit uneven spatial distribution, leading to pigmentation, dullness, or uneven skin tone on the skin surface. Even without a significant increase in overall melanin content, these skin color problems can cause a decrease in the intensity and uniformity of light reflected from the skin, thus affecting the evenness and brightness of skin tone.

[0004] Currently, cosmetic techniques for improving skin tone primarily focus on inhibiting melanin production or blocking its transport to keratinocytes. For example, this involves inhibiting tyrosinase activity, regulating melanin synthesis-related signaling pathways, or intervening in melanin transport processes to reduce the overall level of melanin in the skin. However, these techniques, which typically aim to reduce the total amount of melanin, have limited effectiveness in improving uneven skin tone and dullness caused by abnormal spatial distribution of melanin.

[0005] In recent years, with the deepening of research on skin optical measurements and intradermal chromophores, it has become increasingly clear that skin appearance color is not only related to melanin content, but also to the spatial distribution of melanin in the skin and its interaction with inflammatory responses, oxidative stress, and cellular metabolic processes. Nevertheless, existing cosmetic compositions lack systematic and targeted solutions that can synergistically regulate these multiple factors to improve melanin distribution and skin optical uniformity.

[0006] For example, Chinese patent CN 117695178 B discloses a plant extract composition with whitening effects, using extracts of Centella asiatica, Hovenia dulcis, and Morus alba root bark. This composition synergistically regulates melanin production and metabolism by modulating tyrosinase activity and promoting autophagy. This approach primarily aims to inhibit melanin production and accelerate its degradation, with the evaluation system still focusing on changes in melanin content at the cellular or tissue level. However, from the perspective of skin optical properties, this approach does not address the regulation of melanin spatial distribution, nor does it consider the amplifying effect of factors such as inflammation and oxidative stress on uneven local melanin deposition. In actual skin conditions, even with low overall melanin levels, local melanin aggregation or imbalanced distribution can significantly reduce the skin's uniformity of visible light reflection, resulting in mottled skin tone, dullness, and other superficial problems. This existing technology fails to provide a systematic solution to this key contradiction; its whitening improvement path remains limited to "reducing pigmentation" rather than "optimizing pigment distribution."

[0007] For example, Chinese patent CN118649103 A discloses a composition with soothing, whitening, and firming effects, comprising ascorbic acid, four o'clock flower extract, carnosine, kapok flower extract, ubiquinone, β-glucan, panthenol, bisabolol, and ginger root extract. This formulation achieves multiple effects through the combination of various active ingredients, but its whitening mechanism still follows the traditional "inhibition of melanin synthesis + anti-oxidation" pathway, without addressing concepts such as "melanin spatial distribution regulation" or "optical uniformity."

[0008] In summary, existing technologies have not addressed the technical issues of "improving local melanin deposition," "adjusting the spatial distribution of melanin," and "enhancing the optical uniformity of the skin." They also lack technical solutions to elevate "the uniformity of melanin distribution" to a regulatory target on par with or even more critical than "total melanin," in order to improve skin color issues. Summary of the Invention

[0009] As mentioned above, existing technologies lack effective means to improve local melanin deposition, adjust the spatial distribution of melanin, and enhance the optical uniformity of the skin. In order to comprehensively improve skin color problems, this invention provides a whitening composition that regulates the spatial distribution of melanin and enhances the optical uniformity of the skin, and its application.

[0010] The whitening composition provided in this application for regulating the spatial distribution of melanin and improving the optical uniformity of skin improves the appearance color and optical uniformity of skin by regulating the melanin-related biological processes and their spatial distribution in the skin, thereby reducing uneven skin tone and dullness.

[0011] The objective of this invention can be achieved through the following technical solutions: This application first provides a whitening composition for regulating the spatial distribution of melanin and improving the optical evenness of the skin, comprising the following components in parts by weight: 0.5-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.01~0.5 parts; Grape seed extract 0.05~0.2 parts.

[0012] In one embodiment of the present invention, preferably, the whitening composition for regulating the spatial distribution of melanin and improving the optical uniformity of skin comprises the following components in parts by weight: 1-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.05~0.1 parts; Grape seed extract 0.05~0.1 parts.

[0013] In one embodiment of the present invention, in the complex of bisabolol and ginger root extract, the mass ratio of bisabolol to ginger root extract is (99-99.9):(1-0.1), preferably, the mass ratio of bisabolol to ginger root extract is 99:1.

[0014] In one embodiment of the present invention, the ginger root extract is a natural extract obtained from the root of ginger (Zingiber officinale Roscoe), a plant of the ginger family (CAS number 84696-15-1). Its main components include gingerene, gingerol, bisabolene, α-curcumene, methylheptenone, gingerol, volatile oil, and diphenylheptane, among other natural components. The preparation and production process of ginger root extract have been provided in numerous publications and is commercially available.

[0015] In one embodiment of the present invention, the hydrolyzed vegetable protein is called HYDROLYZEDVEGETABLE PROTEIN and has the CAS number 100209-45-8.

[0016] The present invention further provides an application of a whitening composition that regulates the spatial distribution of melanin and improves the optical uniformity of the skin, wherein the whitening composition that regulates the spatial distribution of melanin and improves the optical uniformity of the skin is used to prepare cosmetics.

[0017] The cosmetic product can be any form of cosmetic or makeup product, preferably a skin care lotion, serum, lotion, cream, etc. The required base ingredients vary depending on the type of cosmetic product. The cosmetic product can improve skin appearance and optical uniformity by regulating melanin-related biological processes and their spatial distribution in the skin, thereby reducing uneven skin tone and dullness.

[0018] The present invention further provides a cosmetic product that regulates the spatial distribution of melanin and improves the optical uniformity of the skin, wherein the cosmetic product contains the whitening composition that regulates the spatial distribution of melanin and improves the optical uniformity of the skin.

[0019] In one embodiment of the present invention, the content of the complex of bisabolol and ginger root extract in the cosmetic is 0.05-0.3% by mass, the content of potassium methoxysalicylate in the cosmetic is 0.05-0.3%, the content of hydrolyzed plant protein in the cosmetic is 0.001-0.05%, and the content of grape seed extract in the cosmetic is 0.005-0.02%.

[0020] In one embodiment of the present invention, the cosmetic is a whitening essence, which contains the whitening composition for regulating the spatial distribution of melanin and improving the optical uniformity of the skin, base oil, emulsifier, moisturizer, thickener, chelating agent, antioxidant, fragrance, and water.

[0021] In one embodiment of the present invention, the base oil is selected from one or more of glyceryl tri(ethylhexanoate), phytosterol / octyldodecyl lauroyl glutamate, polymethylsilsesquioxane, caprylic / decanoic acid triglyceride or isohexadecane.

[0022] In one embodiment of the present invention, the emulsifier is selected from one or more of polysorbate-80, sorbitan oleate, or PEG-11 methyl ether polydimethylsiloxane.

[0023] In one embodiment of the present invention, the moisturizer is selected from one or more of butylene glycol, glycerin, propylene glycol, dipropylene glycol, 1,2-hexanediol, and 1,2-pentanediol; In one embodiment of the present invention, the thickener is selected from one or more of sodium acrylate / sodium acryloyl dimethyl taurate copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, or carbomer.

[0024] The chelating agent described in this invention is selected from at least one of EDTA-disodium, EDTA-tetrasodium, or a combination thereof; In one embodiment of the present invention, the antioxidant is selected from one or more of p-hydroxyacetophenone or sodium metabisulfite.

[0025] In one embodiment of the present invention, the fragrance agent is selected from one or more of cosmetic fragrances, (daily) fragrances, edible fragrances, or various aromatic essential oils.

[0026] The present invention further provides a method for preparing the whitening essence, comprising the following steps: S1. The emulsifier and base oil are heated to dissolve and mixed to obtain the oil phase; S2. Mix water, humectant, and potassium methoxysalicylate evenly, then add thickener and chelating agent separately and stir until dissolved to obtain an aqueous phase. S3. Stir and mix the aqueous phase and oil phase, and homogenize them; S4. Add the complex of bisabolol and ginger root extract, hydrolyzed plant protein, grape seed extract, antioxidants and fragrance to the homogenized mixture, and stir until well mixed.

[0027] Compared with the prior art, the advantages and beneficial effects of the present invention are mainly reflected in the following aspects: Based on skin optics theory, this invention not only aims to reduce the total amount of melanin, but also to regulate the skin's apparent color and optical uniformity by improving local melanin deposition and adjusting its spatial distribution. This results in a multi-level synergistic combination of cosmetic ingredients.

[0028] Firstly, this invention utilizes a combination of bisabolol and ginger root extract to regulate inflammatory mediators and stimulating signals, thereby reducing abnormal activation and local accumulation of melanin under inflammatory conditions and decreasing the probability of uneven melanin distribution at its source. This effect does not directly inhibit melanin production, but rather improves the skin microenvironment, preventing excessive pigment deposition in specific areas and providing a foundation for subsequent improvements in optical uniformity.

[0029] Secondly, this invention introduces 4-MSK (potassium methoxysalicylate), which, while gently inhibiting melanin production, synergistically regulates the differentiation state of keratinocytes, allowing melanin to migrate and distribute more evenly outward during epidermal renewal. This helps reduce pigmentation differences caused by imbalances in keratin renewal, thereby improving the uniformity of skin's visible light reflection.

[0030] Furthermore, in this invention, hydrolyzed plant protein and grape seed extract are used synergistically to regulate the abnormal melanin deposition that has already formed and the accompanying oxidative stress state. By promoting the autophagy clearance of melanin and reducing the impact of the oxidative environment on local pigmentation, the existing pigmentation can be repaired.

[0031] In summary, this invention, for the first time, constructs a technical solution that differs from traditional "melanin-inhibiting whitening" methods, focusing on the regulation of melanin distribution and the improvement of skin optical uniformity. While effectively reducing the total amount of melanin, it further improves uneven skin tone and dull appearance. Detailed Implementation

[0032] This application provides a skin-whitening composition that regulates the spatial distribution of melanin and improves the optical evenness of the skin, comprising the following components in parts by weight: 0.5-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.01~0.5 parts; Grape seed extract 0.05~0.2 parts.

[0033] Preferably, the whitening composition for regulating the spatial distribution of melanin and improving the optical evenness of the skin comprises the following ingredients in parts by weight: 1-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.05~0.1 parts; Grape seed extract 0.05~0.1 parts.

[0034] This application further provides, based on the above, a cosmetic product that regulates the spatial distribution of melanin and improves the optical evenness of the skin, wherein the cosmetic product contains the whitening composition that regulates the spatial distribution of melanin and improves the optical evenness of the skin. Based on a 100% mass content, the content of the complex of bisabolol and ginger root extract in the cosmetic product is 0.05-0.3%, the content of potassium methoxysalicylate in the cosmetic product is 0.05-0.3%, the content of hydrolyzed plant protein in the cosmetic product is 0.001-0.05%, and the content of grape seed extract in the cosmetic product is 0.005-0.02%.

[0035] The whitening composition provided in this application, which regulates the spatial distribution of melanin and improves the optical evenness of the skin, has the following description of the functions of its main components: A complex of bisabolol and ginger root extract: Its core ingredients include high-purity bisabolol and organic ginger root extract. Through their synergistic effect, they can effectively relieve skin redness, soothe inflammation, and enhance skin tolerance, making it suitable for various scenarios such as sensitive skin care, post-shave repair, and post-sun repair. Bisabolol inhibits primary inflammatory markers (IL-1α, TNF-α, IL-6, IL-8), while ginger root extract synergistically inhibits secondary inflammatory responses (COX-2, PGE-2). The combination of these two ingredients has a synergistic effect, and in clinical trials of rashes induced by sodium lauryl sulfonate, the combination showed better redness-reducing effects than the single component.

[0036] 4-MSK (potassium methoxysalicylate): 4-MSK is a lipid-soluble salicylic acid derivative. On one hand, it can inhibit tyrosinase activity, thereby reducing melanin production; on the other hand, salicylic acid has the effect of normalizing keratinocyte differentiation. As its derivative, 4-MSK can also regulate the differentiation process of keratinocytes. 4-MSK can significantly promote the expression of multiple differentiation markers in keratinocytes, including early differentiation markers keratin KRT1 and KRT10, as well as terminal differentiation markers filaggrin (FLG) and ivory lignin (IVL). In this application, the mechanism by which 4-MSK promotes keratinocyte differentiation is utilized, and ultimately, a whitening effect is achieved by accelerating melanin metabolism.

[0037] Hydrolyzed vegetable protein: The core mechanism of action of the hydrolyzed plant protein in this application lies in its ability to upregulate the expression of the autophagy regulator AMBRA1, thereby increasing cellular autophagy flux, promoting the clearance of melanin and lipofuscin in the skin, reducing their excess and abnormal distribution, and thus improving skin radiance. Verification has shown that hydrolyzed plant protein can effectively reduce melanin expression levels and decrease lipofuscin production under oxidative stress. Clinical test results indicate that this ingredient can improve skin whiteness and radiance, reduce yellowness, and improve skin smoothness.

[0038] Grape seed extract: Grape seeds contain flavonoid polyphenols, which are recognized as highly effective natural antioxidants for scavenging free radicals. This application utilizes eutectic supramolecular technology to extract specific components from the plant with high purity, and then employs encapsulation technology to improve the water solubility and transdermal absorption of the active ingredients, thereby enhancing bioavailability. The main effects include: a. Source-level antioxidant: Promotes the scavenging of ABTS free radicals and the scavenging of reactive oxygen species (ROS) in zebrafish embryos; b. Anti-inflammatory and soothing: Inhibits LPS-induced NO production in macrophages and inhibits neutrophil aggregation in zebrafish embryos; c. Whitening: Inhibits c-Kit protein expression in B16 cells, blocks signals, and reduces melanocyte activation; inhibits tyrosinase activity and melanin synthesis in B16 cells (biochemical & cellular); enhances melanocyte autophagy, restoring natural whiteness.

[0039] The following examples illustrate the sources of the raw materials: Ginger root extract, CAS number 84696-15-1.

[0040] Hydrolyzed vegetable protein, CAS number 100209-45-8.

[0041] Grape seed extract, English name VITIS VINIFERA (GRAPE) SEED EXTRACT, CAS number: 84929-27-1.

[0042] In the following examples, the mass ratio of bisabolol to ginger root extract in the complex of bisabolol and ginger root extract is 99:1.

[0043] The present invention will now be described in detail with reference to specific embodiments.

[0044] Examples 1, 2, 3, and Comparative Examples 1-8 Examples 1, 2, 3, and Comparative Examples 1-8 provide whitening serums with different formulations, as shown in Table 1.

[0045] Table 1 Whitening Essence Formula Table The preparation method of the whitening essence includes the following steps: S1. The emulsifier and base oil are heated to dissolve and mixed to obtain the oil phase; S2. Mix water, moisturizer, and 4-MSK (when the whitening composition contains 4-MSK) evenly, then add thickener and chelating agent separately and stir until dissolved to obtain an aqueous phase; S3. Stir and mix the aqueous phase and oil phase, and homogenize them; S4. Add the complex of bisabolol and ginger root extract (when the whitening composition contains the complex of bisabolol and ginger root extract), hydrolyzed plant protein (when the whitening composition contains hydrolyzed plant protein), grape seed extract (when the whitening composition contains grape seed extract), antioxidant and fragrance to the homogenized mixture, and stir to mix evenly.

[0046] The main difference between Examples 1-3 and Comparative Examples 1-8 is that the contents of the complex of bisabolol and ginger root extract, potassium methoxysalicylate, hydrolyzed plant protein, and grape seed extract in the whitening compositions in Table 1 are different.

[0047] The differences in the whitening composition content of Examples 1-3 and Comparative Examples 1-8 are shown in Table 2.

[0048] Table 2: Content of whitening composition ingredients in Examples 1-3 and Comparative Examples 1-8 The comparative examples and embodiments listed in Table 2 are all designed based on a combination system of 4-MSK, bisabolol and ginger root extract complex, hydrolyzed plant protein and grape seed extract. The pathways of action and synergistic effects of different components in the whitening regulation process were verified using the controlled variable method and the ratio gradient method. The preparation processes of each comparative example and embodiment are consistent, except that the corresponding active ingredients are not added or are reduced in the respective comparative examples.

[0049] Comparative Examples 1-8 were used to remove one or two components from the combined system by controlling variables, thereby removing the components related to melanin production inhibition, skin microenvironment regulation, or melanin autophagy clearance. This was used to verify the differences in the effects of each single pathway on melanin regulation, and to distinguish the mechanism of action between the reduction of total melanin and the improvement of spatial distribution.

[0050] Examples 1-3 construct a combined system that simultaneously inhibits melanin production, regulates the skin microenvironment, and clears melanin through different proportions of various active ingredients within a reasonable range. The synergistic effects of the compositions under different ratios are compared to screen out a scheme with better effects in improving the spatial distribution of melanin and the optical uniformity of the skin.

[0051] Performance verification of products in the examples and comparative examples 1. Security Testing 1) The serums of Examples 1-3 and Comparative Examples 1-8.

[0052] 2) Number of participants: 36, including 18 males and 18 females, aged between 18 and 50 years old, all of whom met the criteria for participants.

[0053] 3) Testing method: Thirty-six participants who met the criteria were randomly divided into 12 groups, corresponding to Examples 1-3, Comparative Examples 1-8, and the blank group (without any sample applied), as shown in Table 2. Each group consisted of three participants. Safety was tested by a third-party testing agency.

[0054] Choose an area not exceeding 50mm.2 A suitable patch applicator with a depth of approximately 1 mm was used. Approximately 0.02-0.025 ml (g) of the test substance was added to the applicator using a closed patch test method. The applicator was applied to the flexor side of the subject's forearm. After 24 hours, the test substance was removed, and skin reactions were observed at 0.5 h, 24 h, and 48 h after removal. The results were recorded according to the skin reaction grading standards in the "Cosmetic Safety Technical Regulations 2015".

[0055] The results of the security test are shown in Table 3.

[0056] Table 3 Results of patch experiment Remark: Skin Reaction Grading Standards: Grade 0: Negative reaction; Grade 1: Suspicious reaction; only slight erythema; Grade 2: Weak positive reaction (erythema reaction); erythema, infiltration, edema, and papules may be present; Grade 3: Strong positive reaction (herpes reaction); erythema, infiltration, edema, papules, herpes: the reaction may extend beyond the tested area; Grade 4: Extremely strong reaction (confluent herpes simplex reaction): obvious erythema, severe infiltration, edema, confluent herpes simplex, reaction extending beyond the test area.

[0057] The results in Table 3 show that Examples 1-3 and 1-8 were non-irritating and passed the safety test.

[0058] 2. Efficacy Evaluation Test When evaluating efficacy, the comparative and implementation examples were verified through human efficacy tests in both in vivo and in vitro to assess their effectiveness in regulating total melanin, inflammatory factors, melanin autophagy, and skin tone evenness.

[0059] 2.1 In vitro experiments (1) Total melanin content determination (B16F10 cell model) A. Test samples: Comparative Examples 1-8 and Examples 1-3.

[0060] B. Experimental Methods: The inhibitory effect of the sample on melanin production was evaluated using a mouse melanoma cell (B16F10) model. B16F10 cells were seeded in 96-well plates and cultured for 24 hours. Then, α-MSH (100 nM) was added to induce melanin production, and the test sample (0.125%) was added simultaneously. After culturing for another 72 hours, the culture medium was discarded, and the intracellular melanin was dissolved in 1N NaOH. The absorbance was measured at 475 nm. The α-MSH stimulation group without the sample was used as a control, and the melanin inhibition rate of each group was calculated.

[0061] C. Calculation formula: Melanin inhibition rate = (Melanin content in the stimulation group - Melanin content in the sample group) / Melanin content in the stimulation group 100% (2) Clearing inflammatory factors (IL-1α) A. Test samples: Comparative Examples 1-8 and Examples 1-3.

[0062] B. Experimental Methods: The anti-inflammatory effect of the samples was evaluated using a human keratinocyte (HaCaT) model. HaCaT cells were seeded in 96-well plates and cultured until adherent. After pretreatment with the test samples for 2 hours, lipopolysaccharide (LPS, 1 μg / mL) was added for stimulation for 24 hours. Cell supernatant was collected, and the secretion level of the inflammatory cytokine IL-1α was detected using an IL-1α ELISA kit. The LPS-only stimulation group served as a control, and the IL-1α inhibition rate of each group was calculated to reflect the anti-inflammatory ability of the samples.

[0063] C. Calculation formula: IL-6 clearance rate = (Concentration of IL-1α in the stimulation group - Concentration of IL-1α in the sample group) / Concentration of IL-1α in the stimulation group 100% The results of melanin inhibition rate and IL-6 clearance rate are shown in Table 3.

[0064] Table 4. Melanin inhibition rate and IL-6 clearance rate of different embodiments and comparative examples 2.2 Evaluation of Human Efficacy After preliminary verification through in vitro experiments as shown in Table 4, further human efficacy evaluations were conducted on Comparative Examples 1-8 and Examples 1-3. The skin melanin index (MI) was measured using a Mexameter® MX18 skin melanin analyzer, and the individual color angle (ITA°) was measured using a CHROMA METER CR-400 skin colorimeter.

[0065] (1) Test samples: Comparative Examples 1-8, Examples 1-3 (2) Subjects: 18 women aged 18-60 years (3 in each group) with obvious facial pigmentation (not freckles, not moles).

[0066] (3) Apply the test substance continuously for 8 weeks, and perform instrument measurements on day 0, week 2, week 4 and week 8.

[0067] (4) The test results can be calculated using the following formula: Rate of change = (Analysis value after product use - Analysis value before product use) ÷ Analysis value before product use × 100% The rate of change of skin color MI and ITA° values ​​of the samples used in Examples 1-3 and Comparative Examples 1-8 is shown in Table 5.

[0068] Table 5. Rate of change of skin color MI and ITA° values ​​in different embodiments and comparative examples Based on human efficacy experiments, the essence products containing the compositions of Examples 1-3 can reduce the total amount of melanin, reduce pigmentation caused by inflammation, even out skin tone, improve skin whiteness, and also have a significant effect on improving local pigmentation.

[0069] The above description of the embodiments is provided to enable those skilled in the art to understand and use the invention. It will be apparent to those skilled in the art that various modifications can be made to these embodiments, and the general principles described herein can be applied to other embodiments without inventive effort. Therefore, the present invention is not limited to the above embodiments, and any improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the invention should be within the protection scope of the present invention.

Claims

1. A skin-whitening composition for regulating the spatial distribution of melanin and improving the optical uniformity of skin, characterized in that, Including the following ingredients in parts by weight: 0.5-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.01~0.5 parts; Grape seed extract 0.05~0.2 parts.

2. The whitening composition for regulating the spatial distribution of melanin and improving the optical uniformity of skin according to claim 1, characterized in that, Including the following ingredients in parts by weight: 1-3 parts of a complex of bisabolol and ginger root extract; Potassium methoxysalicylate 0.5-3 parts; Hydrolyzed vegetable protein 0.05~0.1 parts; Grape seed extract 0.05~0.1 parts.

3. A whitening composition for regulating the spatial distribution of melanin and improving the optical uniformity of skin according to claim 1 or 2, characterized in that, In the complex of bisabolol and ginger root extract, the mass ratio of bisabolol to ginger root extract is (99~99.9):(0.1~1), preferably, the mass ratio of bisabolol to ginger root extract is 99:

1.

4. The application of the whitening composition according to claim 1 or 2 for regulating the spatial distribution of melanin and improving the optical uniformity of skin, characterized in that, The whitening composition that regulates the spatial distribution of melanin and improves the optical uniformity of the skin is used in the preparation of cosmetics.

5. A cosmetic product for regulating the spatial distribution of melanin and improving the optical evenness of the skin, characterized in that, The cosmetic contains the whitening composition according to claim 1 or 2, which regulates the spatial distribution of melanin and improves the optical uniformity of the skin.

6. A cosmetic product for regulating the spatial distribution of melanin and improving the optical evenness of skin according to claim 5, characterized in that, Based on a mass content of 100%, the content of the complex of bisabolol and ginger root extract in cosmetics is 0.05~0.3%, the content of potassium methoxysalicylate in cosmetics is 0.05~0.3%, the content of hydrolyzed plant protein in cosmetics is 0.001%~0.05%, and the content of grape seed extract in cosmetics is 0.005~0.02%.

7. A cosmetic product for regulating the spatial distribution of melanin and improving the optical evenness of skin according to claim 5, characterized in that, The cosmetics mentioned are skin care water, serum, lotion or cream.

8. A cosmetic product for regulating the spatial distribution of melanin and improving the optical uniformity of skin according to claim 5, characterized in that, The cosmetic product is a whitening essence, which contains the whitening composition that regulates the spatial distribution of melanin and improves the optical evenness of the skin, base oil, emulsifier, moisturizer, thickener, chelating agent, antioxidant, fragrance, and water.

9. A cosmetic product for regulating the spatial distribution of melanin and improving the optical uniformity of skin according to claim 8, characterized in that, The base oil is selected from one or more of the following: triglyceride (ethylhexanoate), phytosterol / octyldodecyl lauroyl glutamate, polymethylsilsesquioxane, caprylic / decanoic acid triglyceride, or isohexadecane. The emulsifier is selected from one or more of polysorbate-80, sorbitan oleate, or PEG-11 methyl ether polydimethylsiloxane; The moisturizer is selected from one or more of butylene glycol, glycerin, propylene glycol, dipropylene glycol, 1,2-hexanediol, and 1,2-pentanediol; The thickener is selected from one or more of sodium acrylate / sodium acryloyl dimethyl taurate copolymer, acrylate / C10-30 alkanol acrylate crosspolymer, or carbomer; The chelating agent is selected from at least one of EDTA-disodium, EDTA-tetrasodium, or a combination thereof; The antioxidant is selected from one or more of p-hydroxyacetophenone or sodium metabisulfite; The fragrance agent is selected from one or more of the following: cosmetic fragrances, (daily) fragrances, edible fragrances, or aromatic essential oils.

10. A method for preparing a cosmetic product according to claim 8 that regulates the spatial distribution of melanin and improves the optical uniformity of skin, characterized in that, The preparation method of whitening essence includes the following steps: S1. The emulsifier and base oil are heated to dissolve and mixed to obtain the oil phase; S2. Mix water, humectant, and potassium methoxysalicylate evenly, then add thickener and chelating agent separately and stir until dissolved to obtain an aqueous phase. S3. Stir and mix the aqueous phase and oil phase, and homogenize them; S4. Add the complex of bisabolol and ginger root extract, hydrolyzed plant protein, grape seed extract, antioxidants and fragrance to the homogenized mixture, and stir until well mixed.

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