A medicinal and edible plant composition with the efficacy of activating blood and dredging collaterals

Abstract

The application relates to the technical field of deep processing of food and medicine products, and discloses a food and medicine product plant composition with the efficacy of activating blood and dredging collaterals, which is prepared from strong acid pectin and saponin continuous phase, purified water, blood-activating oil phase, and free calcium and alginic acid continuous phase according to specific mass proportions. During preparation, raw peach kernels are subjected to high-temperature hot water pretreatment to inactivate endogenous enzymes and block the generation path of hydrocyanic acid; the blood-activating oil phase and the strong acid continuous phase are sheared to prepare a primary emulsion; free calcium is chelated by citric acid to maintain low viscosity of the system, and the alginic acid continuous phase is mixed; the mixed fluid is subjected to high-pressure homogenization to generate adiabatic temperature rise, trigger the release of free calcium according to the inverse solubility characteristics, and cause in-situ coordination crosslinking of the free calcium and polysaccharides on the surface of oil droplets; and finally, the structure is locked by rapid cooling. The application constructs a high-molecular network coating layer on the interface of oil droplets, effectively blocks the oxidation and volatilization of fat-soluble components, significantly improves the physical stability of the system, and eliminates the safety hazard of cyanide residue from the source.

Description

Technical Field

[0001] This invention relates to the field of deep processing technology for food and medicine homology products, specifically a food and medicine homology plant composition with the effect of promoting blood circulation and clearing the meridians. Background Technology

[0002] Medicinal and edible plants are widely used in health drinks and liquid preparations. Raw peach kernels and angelica are classic ingredients for promoting blood circulation and clearing the meridians. These plant tissues are rich in fat-soluble volatile oils and polyunsaturated fatty acids. Extracting and processing these raw materials into water-based compositions can improve the release rate of active ingredients.

[0003] Traditional preparation processes often employ mechanical pulverization and conventional solvent extraction to obtain fat-soluble components. The extract is then directly dispersed in an aqueous medium. To maintain the physical balance of the oil-water system, surfactants or small-molecule emulsifiers are usually added during production. The processing relies on high-speed shearing or conventional homogenizing equipment to break the oil phase into tiny droplets. Some processes mix sodium alginate or pectin and other macromolecular polysaccharides into the system as simple thickeners. The formed liquid emulsion is finally transported to the end of the production line for conventional heat sterilization.

[0004] However, in existing preparation processes of medicinal and edible plant compositions, surfactants alone are insufficient to construct a dense mechanical barrier layer around oil droplets. Dissolved oxygen easily penetrates the interface, leading to the oxidation of fat-soluble components. Long-term storage of the product easily results in flocculation and phase separation. If polyvalent metal ions are directly introduced into the liquid system to induce coordination cross-linking of alginic acid, local supersaturation occurs instantly upon contact between the ions and the polysaccharide solution. High-viscosity gel blocks rapidly form within the pipeline, clogging the static mixer and high-pressure homogenizing valve components. Furthermore, raw peach kernels naturally contain cyanogenic glycosides and endogenous amygdalin enzymes. Conventional mechanical cell disruption processes destroy the physical isolation of plant cells, allowing these two to fully contact in the aqueous medium and rapidly initiate a hydrolysis reaction. Subsequent emulsification processes, with their pumping and stirring temperatures, promote enzymatic activity, leading to the continuous accumulation of toxic hydrocyanic acid within the system. The final short-time high-temperature sterilization process is insufficient to completely remove the generated cyanide, posing a food safety risk. Therefore, this invention provides a medicinal and edible plant composition with blood-activating and meridian-clearing effects to address the shortcomings of existing technologies. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a composition of medicinal and edible plants with blood-activating and meridian-clearing effects. This solves the problem that existing medicinal and edible plant extracts, when formulated into water-based compositions, suffer from easily oxidized and volatilized fat-soluble components, resulting in poor physical stability of the dispersion system and a tendency to separate and flocculate. Furthermore, formulations containing peach kernels may contain toxic hydrocyanic acid residues if cyanogenic glycosides react with endogenous enzymes during processing, posing a food safety hazard.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] In a first aspect, the present invention provides a medicinal and edible plant composition with the effect of promoting blood circulation and clearing the meridians, using the following technical solution:

[0008] A medicinal and edible plant composition with blood-activating and meridian-clearing effects comprises the following raw materials in parts by weight: 250-400 parts of a continuous phase of strongly acidic pectin and saponins; 200-350 parts of purified water; 20-50 parts of a blood-activating oil phase; and 130-200 parts of a continuous phase of free calcium and alginic acid.

[0009] By employing the above technical solution, a polymer network coating layer can be constructed on the surface of the blood-activating oil phase under the action of a physical field. This is achieved by compounding a continuous phase and a blood-activating oil phase in a specific mass ratio, utilizing the strongly acidic pectin and saponin continuous phase to provide emulsifying active centers and an acidic medium, combined with the polysaccharide backbone and metal crosslinking ions provided by the free calcium and alginic acid continuous phase. This polymer network coating layer effectively blocks the diffusion and mass transfer process of environmental oxygen into the lipid-soluble components, reduces the loss rate of volatile active ingredients, and improves the long-term physical stability of the entire water-based composition, preventing large particle aggregation and phase separation.

[0010] Preferably, the blood-activating oil phase is made from raw peach kernels and sliced ​​angelica, and the mass ratio of raw peach kernels to sliced ​​angelica is 1:1 to 3.

[0011] By employing the above technical solution, the combination of raw peach kernels and sliced ​​angelica can provide synergistic active ingredients for promoting blood circulation and clearing the meridians. A specific mass ratio ensures that the extracted fat-soluble volatile oil and unsaturated fatty acid mixture has suitable physicochemical properties to form uniform submicron-sized oil droplets in subsequent processes.

[0012] Preferably, the strong acidic pectin and saponin continuous phase is made from hawthorn slices, ginseng slices and extraction solvent, wherein the mass ratio of hawthorn slices to ginseng slices is 3-6:1; and the pH value of the strong acidic pectin and saponin continuous phase is 3.5-4.5.

[0013] By adopting the above technical solution, ginsenosides in ginseng slices, as natural surfactants, can be directionally adsorbed at the oil-water interface to reduce interfacial tension. Hawthorn slices not only provide pectin as a network building material, but also provide abundant natural citric acid. The strongly acidic pH environment of 3.5 to 4.5 ensures that citric acid maintains an appropriate dissociation state, giving it sufficient metal ion chelating ability, providing a chemical basis for controlling the release timing of free calcium ions in subsequent processes.

[0014] Preferably, the continuous phase of free calcium and alginic acid is made from dried kelp and purified water, wherein the mass ratio of dried kelp to purified water is 1:15-20.

[0015] By employing the above-mentioned technical solution, the dried kelp water extract is rich in alginic acid and polyvalent free calcium ions. The specific mass ratio extraction scheme ensures that the concentration ratio of anionic polysaccharide macromolecules to metal cations in the aqueous phase is within an appropriate cross-linking reaction window, providing a sufficient material basis for constructing a robust interfacial structure.

[0016] Secondly, the present invention provides a method for preparing a medicinal and edible plant composition with the effect of promoting blood circulation and clearing the meridians, using the following technical solution:

[0017] A method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, comprising:

[0018] S1. Add strong acidic pectin and saponin continuous phase and purified water to a high-shear emulsification kettle with a water bath jacket, start stirring and mix evenly, control the jacket temperature to maintain the system constant temperature, start the homogenizer and slowly pump in the blood-activating oil phase, and continuously shear and disperse to obtain the primary emulsion.

[0019] S2. Free calcium and alginate are continuously pumped into the primary emulsion at the same temperature into a pipeline static mixer, and the fluid contact time is controlled to obtain a mixed fluid in a low viscosity state.

[0020] S3. The mixed fluid flowing out of the static mixer is directly introduced into the inlet of the high-pressure homogenizer. The fluid is squeezed under high pressure by the homogenizer valve and instantly heated by the adiabatic shear heating effect, triggering the reverse solubility characteristic to release free calcium ions, which then undergo in-situ cross-linking on the surface of the oil droplets.

[0021] S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into the heat exchanger to rapidly reduce the system temperature to lock the cross-linking structure. Then, it is pumped into the ultra-high temperature instantaneous sterilization pipeline, cooled down, and aseptically filled to obtain the medicinal and edible plant composition.

[0022] By adopting the above technical solution, this invention utilizes spatial isolation mixing and thermodynamic phase change switching to achieve continuous production of microencapsulated blood-activating oil phases, including the following steps:

[0023] During the preparation of the primary emulsion, ginsenoside molecules and some pectin long chains are oriented and anchored on the surface of dispersed oil droplets, forming an initial steric hindrance layer.

[0024] In the inline static mixer, the two fluids are instantaneously mixed. At this time, the system is under a preset low-temperature condition, and the citrate ions in the strongly acidic continuous phase chelate the free calcium ions introduced into the kelp continuous phase. This chemical masking effect blocks the instantaneous coordination of calcium ions with alginic acid, keeping the system in a low-viscosity flow state and avoiding the formation of macroscopic gel blocks and subsequent blockage of the high-pressure pump.

[0025] The fluid entering the high-pressure homogenizing valve generates extreme mechanical shear and cavitation energy release, triggering a strong adiabatic temperature rise and forcibly pushing up the local microscopic temperature. As the temperature crosses a specific critical value, calcium citrate in the system undergoes a reverse solubility phase transition, leading to the violent release of free metal ions. Under thermal drive and turbulent flow, the released calcium ions rapidly coordinate with the alginate and low-ester pectin backbone distributed at the submicron oil droplet interface, completing in-situ cross-linking and shaping to form an interfacial polymer network.

[0026] The forced extraction and cooling process stabilized the interfacial structure, preventing secondary phase dissociation caused by temperature fluctuations. This in-situ crosslinking method resulted in a product with a lower centrifugal instability index, preventing oxidative degradation of the active ingredients.

[0027] Preferably, before step S1, the pretreatment and preparation method of the blood-activating oil phase is as follows: blanch raw peach kernels in boiling water at 95-100°C for 5-10 minutes, remove them and immediately immerse them in purified water at 5-10°C for rapid cooling and mechanical peeling; mix and pulverize the peeled peach kernels with sliced ​​angelica, place them in a supercritical carbon dioxide extraction vessel, and continuously extract for 2-4 hours under the conditions of extraction pressure of 25-35 MPa and extraction temperature of 40-50°C; collect the lipid-soluble mixture after decomposition under reduced pressure for later use.

[0028] By employing the above-mentioned technical solution, the boiling water blanching treatment at 95–100℃ causes irreversible denaturation and folding of the protein conformation of endogenous amygdalin in raw peach kernels. This pretreatment step blocks the enzymatic reaction chain of cyanogenic glycosides, preventing the spontaneous synthesis of hydrogen cyanide in the system during subsequent homogenization and heating processes, thereby controlling the residual cyanide in the final product within a safe range. Supercritical fluid extraction avoids the thermal degradation of fat-soluble components caused by conventional hot reflux extraction.

[0029] Preferably, the preparation method of the continuous phase of strongly acidic pectin and saponins includes: mixing hawthorn slices and ginseng slices, adding purified water, and extracting at a constant temperature of 70-80℃ for 1.5-2.5 hours, filtering, and then concentrating under negative pressure to 1 / 3 to 1 / 2 of the original extract mass for later use; the preparation method of the continuous phase of free calcium and alginic acid includes: pulverizing dried kelp, adding purified water, and extracting at a constant temperature of 50-60℃ with stirring for 2-3 hours, centrifuging, and then filtering the supernatant through a microporous membrane with a pore size of 0.2-0.45 micrometers for later use.

[0030] By employing the above technical solutions, the water extraction and concentration process under specific conditions can efficiently dissolve functional polysaccharides and organic acids from hawthorn and ginseng, ensuring the subsequent chelation capacity and interfacial activity of the system. The kelp extract is precisely filtered through a microporous membrane with a specific pore size to remove suspended impurities such as insoluble cellulose, ensuring the homogeneity of the cross-linking reaction system.

[0031] Preferably, step S1 further includes: strictly controlling the system temperature to be maintained at 30-35°C; setting the high-shear disperser speed to 3000-5000 rpm, and the continuous shear dispersion time to 10-15 minutes.

[0032] By employing the above technical solution, a temperature window of 30 to 35°C is the key thermodynamic boundary condition for maintaining the stability of citric acid-chelated calcium ions, ensuring that the free calcium ion concentration remains at a low threshold. Simultaneously, by combining this with appropriate rotation speed and time, a uniform particle size distribution in the primary emulsion droplets is ensured.

[0033] Preferably, in step S2, the free calcium and alginate continuous phases are simultaneously pumped into the inline static mixer along with the primary emulsion at the same temperature, and the fluid contact time is controlled to be 0.2 to 0.5 seconds; in step S3, the pressure drop of the first-stage homogenizing valve of the high-pressure homogenizer is 35 to 45 MPa, causing the local temperature of the fluid to rise instantaneously from 30 to 35°C to 55 to 65°C within the homogenizing valve.

[0034] By employing the above technical solution, the short mixing time of 0.2 to 0.5 seconds limits the excessive diffusion of ions inside the static mixer, further reducing the risk of pipeline blockage. The adiabatic temperature rise generated by the specific pressure drop of the homogenizing valve raises the fluid temperature to above 55°C, triggering a large-scale dechelation of calcium ions and interfacial recombination reaction of polysaccharide segments in the local microenvironment.

[0035] Preferably, in step S4, the dispersion is forcibly introduced into the heat exchanger within 3 to 5 seconds to lower the system temperature to 20 to 25°C; the conditions for ultra-high temperature instantaneous sterilization are: maintaining at 135 to 140°C for 3 to 5 seconds.

[0036] By adopting the above technical solution, the rapid cooling effect is used to promote the stabilization of the interfacial polymer network structure. The short-term ultra-high temperature instantaneous sterilization kills microorganisms while avoiding prolonged heating that could damage the locked coating structure and unstable effective components inside the oil phase.

[0037] This invention provides a medicinal and edible plant composition with blood-activating and meridian-clearing effects. It possesses the following beneficial effects:

[0038] 1. This invention combines a continuous phase of strongly acidic pectin and saponins, a continuous phase of free calcium and alginic acid, and a blood-activating oil phase. Utilizing the coordination and cross-linking of the pectin, alginic acid, and other polysaccharide backbones with metallic calcium ions, a polymeric network coating layer is constructed at the oil-water interface. This effectively blocks the diffusion and mass transfer of ambient oxygen into the lipid-soluble components, reduces the loss of volatile active ingredients in the blood-activating oil phase, and simultaneously improves the physical stability of the entire water-based composition, preventing large particle aggregation and phase separation during long-term storage.

[0039] 2. In the initial stage of pipeline mixing, this invention utilizes citric acid in the strongly acidic continuous phase to chemically chelate free calcium ions, maintaining the system in a low-viscosity flow state and avoiding pipeline blockage caused by premature cross-linking of alginic acid. When the fluid passes through the high-pressure homogenizing valve, an adiabatic temperature rise is generated, triggering the release of calcium ions by reversing the solubility characteristics of calcium citrate. This allows the calcium ions to rapidly coordinate with polysaccharide segments at the submicron oil droplet interface, completing in-situ cross-linking and improving the density of the coating structure and production efficiency.

[0040] 3. Before extracting the blood-activating oil phase, the present invention pre-treats the raw peach kernels with high-temperature boiling water blanching and rapid cooling. This physical thermal shock causes irreversible denaturation of the protein conformation of endogenous amygdalin in the peach kernels, interrupting the enzymatic reaction pathway of cyanogenic glycoside hydrolysis. This ensures that hydrocyanic acid will not spontaneously generate during subsequent homogenization shearing and heat sterilization processes, effectively controlling the residual amount of cyanide in the product and eliminating potential food safety hazards. Attached Figure Description

[0041] Figure 1 This is a flowchart of the preparation steps of the present invention;

[0042] Figure 2 Figure 1 shows the test results of the evolution relationship of fluid physicochemical parameters at the characteristic nodes of the present invention; wherein, Figure (a) is the evolution diagram of instantaneous fluid temperature at each process node, and Figure (b) is the evolution diagram of free calcium ion concentration at each process node.

[0043] Figure 3 Figure 1 shows the test results of the engineering operability and centrifugal stability evaluation of the dispersion system of the present invention; wherein, Figure (a) is a comparison of the viscosity of the inlet material of the homogenizer under different process schemes, and Figure (b) is an evaluation of the accelerated centrifugal instability of each group of dispersion systems.

[0044] Figure 4 Figure 1 shows the test results of the retention rate of the core components during the high-temperature accelerated storage period of the present invention; wherein, Figure (a) is a graph of the degradation kinetics of the active ingredients under different process schemes, and Figure (b) is a comparison of the retention rate at the end of accelerated storage under different process schemes. Detailed Implementation

[0045] The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0046] The main raw materials and reagents used in the following examples and comparative examples have the following sources and specifications. Reagents not specifically mentioned are all commercially available analytical grade or higher grade products.

[0047] Peach kernels are made from the dried, mature seeds of the peach (Prunus persica), a plant in the Rosaceae family, with a moisture content of less than 8%. Angelica sinensis is made from the dried root of the Angelica sinensis, a plant in the Apiaceae family, with a ferulic acid content of not less than 0.05%. Hawthorn is made from the dried, mature fruit of the hawthorn (Lycium barbarum), a plant in the Rosaceae family, with a citric acid content of not less than 5.0% when calculated on a dried basis. Kelp is made from the dried thallus of the kelp (Laminaria japonica), a plant in the Laminariaceae family, with a moisture content of less than 12%. Ginseng is made from the dried root and rhizome of the ginseng (Panax ginseng), a plant in the Araliaceae family, with a total ginsenoside Rg1 and ginsenoside Re content of not less than 0.3%.

[0048] Ligustrazine: CAS No. 4431-01-0; Ginsenoside Rb1: CAS No. 41753-43-9; Amygdalin: CAS No. 29883-15-6.

[0049] Pectin: CAS number 9000-69-5, the main chain is composed of linear repeating units formed by D-galacturonic acid linked by α-1,4-glycosidic bonds, the free carboxyl groups of galacturonic acid residues are esterified with methanol, the degree of esterification ranges from 20% to 35%, and the weight average molecular weight ranges from 50,000 to 80,000 Daltons.

[0050] Sodium alginate: CAS number 9005-38-3, the repeating unit is composed of β-D-mannuronic acid and α-L-guluronic acid linked by 1,4-glycosidic bonds, including mannuronic acid homopolymer blocks, guluronic acid homopolymer blocks and copolymer blocks of the two arranged alternately, the molar ratio of mannuronic acid to guluronic acid is 0.5 to 1.5, and the weight average molecular weight ranges from 100,000 to 150,000 Daltons.

[0051] Preparation Example 1:

[0052] This preparation example provides a method for preparing a blood-activating oil phase, including the following steps:

[0053] Weigh 20 parts by weight of raw peach kernels, blanch them in boiling water at 100℃ for 8 minutes, remove them and immediately immerse them in purified water at 5℃ for rapid cooling and mechanical peeling. Mix the peeled peach kernels with 40 parts by weight of sliced ​​angelica root, pulverize them through a 50-mesh sieve, and place the powder in a supercritical carbon dioxide extraction vessel. Set the extraction pressure to 30 MPa, the extraction temperature to 45℃, and the carbon dioxide flow rate to 20 L / h, and continue extraction for 3 hours. After depressurization and analysis in the separation vessel, collect the mixture of fat-soluble volatile oil and unsaturated fatty acids at the bottom, store it at 4℃ in the dark, and use it as the blood-activating oil phase for later use.

[0054] Preparation Example 2:

[0055] This preparation example provides a method for preparing a blood-activating oil phase, including the following steps:

[0056] Weigh 20 parts by weight of raw peach kernels, blanch them in boiling water at 95°C for 5 minutes, then immediately immerse them in purified water at 10°C for rapid cooling and mechanical peeling. Mix the peeled peach kernels with 20 parts by weight of sliced ​​angelica root, pulverize them through a 40-mesh sieve, and place the powder in a supercritical carbon dioxide extraction vessel. Set the extraction pressure to 25 MPa, the extraction temperature to 40°C, and the carbon dioxide flow rate to 15 L / h, and continue extraction for 2 hours. After depressurization and analysis in the separation vessel, collect the mixture of fat-soluble volatile oil and unsaturated fatty acids at the bottom, store it at 4°C in the dark, and use it as the blood-activating oil phase for later use.

[0057] Preparation Example 3:

[0058] This preparation example provides a method for preparing a blood-activating oil phase, including the following steps:

[0059] Weigh 20 parts by weight of raw peach kernels, blanch them in boiling water at 100℃ for 10 minutes, remove them and immediately immerse them in purified water at 8℃ for rapid cooling and mechanical peeling. Mix the peeled peach kernels with 60 parts by weight of sliced ​​angelica root, pulverize them through a 60-mesh sieve, and place the powder in a supercritical carbon dioxide extraction vessel. Set the extraction pressure to 35 MPa, the extraction temperature to 50℃, and the carbon dioxide flow rate to 25 L / h, and continue extraction for 4 hours. After depressurization and analysis in the separation vessel, collect the mixture of fat-soluble volatile oil and unsaturated fatty acids at the bottom, store it at 4℃ in the dark, and use it as the blood-activating oil phase for later use.

[0060] Preparation Example 4:

[0061] This preparation example provides a method for preparing a continuous phase of free calcium and alginate, including the following steps:

[0062] Weigh 10 parts by weight of dried kelp, pulverize it through a 50-mesh sieve, add 180 parts by weight of purified water, and extract at 55℃ with constant stirring for 2.5 hours. Separate the solid and liquid phases using a centrifuge at 3500 rpm, and collect the supernatant. Filter the supernatant through a microporous membrane with a pore size of 0.3 micrometers to remove insoluble cellulose and impurities, obtaining an aqueous solution rich in alginic acid and polyvalent free calcium ions. Cool the aqueous solution and maintain it at 32℃ for later use.

[0063] Preparation Example 5:

[0064] This preparation example provides a method for preparing a continuous phase of free calcium and alginate, including the following steps:

[0065] Weigh 10 parts by weight of dried kelp, pulverize it through a 40-mesh sieve, add 150 parts by weight of purified water, and extract at 50℃ with constant stirring for 2 hours. Separate the solid and liquid phases using a centrifuge at 3000 rpm, and collect the supernatant. Filter the supernatant through a microporous membrane with a pore size of 0.45 micrometers to remove insoluble cellulose and impurities, obtaining an aqueous solution rich in alginic acid and polyvalent free calcium ions. Cool the aqueous solution and maintain it at 30℃ for later use.

[0066] Preparation Example 6:

[0067] This preparation example provides a method for preparing a continuous phase of free calcium and alginate, including the following steps:

[0068] Weigh 10 parts by weight of dried kelp, pulverize it through a 60-mesh sieve, add 200 parts by weight of purified water, and extract at 60℃ with constant stirring for 3 hours. Separate the solid and liquid phases using a centrifuge at 4000 rpm, and collect the supernatant. Filter the supernatant through a microporous membrane with a pore size of 0.2 micrometers to remove insoluble cellulose and impurities, obtaining an aqueous solution rich in alginic acid and polyvalent free calcium ions. Cool the aqueous solution and maintain it at 35℃ for later use.

[0069] Preparation Example 7:

[0070] This preparation example provides a method for preparing a continuous phase of strongly acidic pectin and saponins, including the following steps:

[0071] Weigh out 40 parts by weight of hawthorn slices and 10 parts by weight of ginseng slices, mix them, add 600 parts by weight of purified water, and extract at 75℃ for 2 hours. Filter the extract through a 250-mesh filter cloth, and then concentrate it to half the original extract mass using a rotary evaporator under a vacuum of -0.07 MPa. The pH of the concentrated solution was measured to be 4.0 using a pH meter. Cool the concentrated solution and maintain it at 32℃ for later use.

[0072] Preparation Example 8:

[0073] This preparation example provides a method for preparing a continuous phase of strongly acidic pectin and saponins, including the following steps:

[0074] Weigh out 30 parts by weight of hawthorn slices and 10 parts by weight of ginseng slices, mix them, add 400 parts by weight of purified water, and extract at 70℃ for 1.5 hours. Filter the extract through a 200-mesh filter cloth, and then concentrate it to one-third of the original extract mass using a rotary evaporator under a vacuum of -0.06 MPa. The pH of the concentrated solution was measured to be 3.5 using a pH meter. Cool the concentrated solution and maintain it at 30℃ for later use.

[0075] Preparation Example 9:

[0076] This preparation example provides a method for preparing a continuous phase of strongly acidic pectin and saponins, including the following steps:

[0077] Weigh out 60 parts by weight of hawthorn slices and 10 parts by weight of ginseng slices, mix them, add 1050 parts by weight of purified water, and extract at 80℃ for 2.5 hours. Filter the extract through a 300-mesh filter cloth, and then concentrate it to two-fifths of its original mass using a rotary evaporator under a vacuum of -0.08 MPa. The pH of the concentrated solution was measured to be 4.5 using a pH meter. Cool the concentrated solution and maintain it at 35℃ for later use.

[0078] See attached document Figure 1 Example 1:

[0079] This embodiment provides a method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, comprising the following steps:

[0080] S1. In a high-shear emulsification vessel equipped with a water bath jacket, add 300 parts by weight of the strong acidic pectin and saponin continuous phase prepared according to the method of Preparation Example 7, and add 300 parts by weight of purified water. Start stirring and mix thoroughly. Strictly control the jacket temperature to maintain the system at 32°C. Start the homogenizer and slowly pump in 35 parts by weight of the blood-activating oil phase prepared according to the method of Preparation Example 1. Set the high-shear disperser speed to 4000 rpm and continuously shear disperse for 12 minutes to obtain a primary emulsion in which ginsenoside molecules are oriented and anchored at the oil-water interface.

[0081] S2. Using a high-precision dual metering pump, 150 parts by mass of the continuous phase of free calcium and alginate prepared according to the method of Preparation Example 4, maintained at 32°C, are simultaneously pumped into a line-type static mixer along with the primary emulsion at the same temperature. By adjusting the pump flow rate, the contact time between the two fluids in the static mixer is controlled to be 0.3 seconds. During this stage, citric acid chelates and masks calcium ions, maintaining the system in a low-viscosity flow state.

[0082] S3. Directly introduce the mixed fluid exiting the static mixer into the inlet of the high-pressure homogenizer. Set the pressure drop of the primary homogenizing valve of the homogenizer to 40 MPa. The fluid is subjected to high-pressure compression through the homogenizing valve, and through the adiabatic shear heating effect, the local temperature of the fluid instantly rises from 32°C to 60°C within the homogenizing valve. Under this high temperature and extremely high shear force, calcium citrate releases free calcium ions due to its reverse solubility characteristics. These calcium ions rapidly cross-link with the emulsion molecules, alginic acid, and pectin at the interface, forming an egg-box structure and constructing a microgel armor in situ on the surface of submicron-sized oil droplets.

[0083] S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into a shell-and-tube heat exchanger within 4 seconds, and the system temperature is rapidly reduced to 25°C using ice water medium to lock the cross-linked structure. The dispersion is then pumped into an ultra-high temperature instantaneous sterilization pipeline, held at 135°C for 4 seconds, and then aseptically filled after cooling to obtain a medicinal and edible plant composition with blood-activating and meridian-clearing effects.

[0084] Example 2:

[0085] This embodiment provides a method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, comprising the following steps:

[0086] S1. Add 250 parts by weight of the strongly acidic pectin and saponin continuous phase prepared according to the method of Preparation Example 8 to a high-shear emulsification vessel equipped with a water bath jacket, add 250 parts by weight of purified water, and start stirring to mix evenly. Strictly control the jacket temperature to maintain the system at 30°C, start the homogenizer, and slowly pump in 20 parts by weight of the blood-activating oil phase prepared according to the method of Preparation Example 2. Set the high-shear disperser speed to 3000 rpm and continuously shear disperse for 10 minutes to obtain the primary emulsion.

[0087] S2. Using a high-precision dual metering pump, 130 parts by mass of the continuous phase of free calcium and alginate prepared according to the method of Preparation Example 5, maintained at 30°C, are simultaneously pumped into a line-type static mixer along with the primary emulsion at the same temperature. By adjusting the pump flow rate, the contact time between the two fluids in the static mixer is controlled to be 0.5 seconds.

[0088] S3. Directly introduce the mixed fluid exiting the static mixer into the inlet of the high-pressure homogenizer. Set the pressure drop of the first-stage homogenizing valve of the homogenizer to 35 MPa. The fluid is compressed under high pressure through the homogenizing valve, and through the adiabatic shear heating effect, the local temperature of the fluid instantly rises from 30°C to 55°C within the homogenizing valve, inducing the release of calcium ions and triggering in-situ cross-linking reactions at the interface, while simultaneously pulverizing the oil phase droplets to the submicron level.

[0089] S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into the shell-and-tube heat exchanger within 5 seconds, and the system temperature is rapidly reduced to 20°C using ice water medium. Then, the dispersion is pumped into the ultra-high temperature instantaneous sterilization pipeline and held at 135°C for 5 seconds. After cooling, it is aseptically filled to obtain a medicinal and edible plant composition with the effect of promoting blood circulation and clearing the meridians.

[0090] Example 3:

[0091] This embodiment provides a method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, comprising the following steps:

[0092] S1. Add 350 parts by weight of the strong acidic pectin and saponin continuous phase prepared according to the method of Preparation Example 9 to a high-shear emulsification vessel equipped with a water bath jacket, and add 350 parts by weight of purified water. Start stirring and mix evenly. Strictly control the jacket temperature to maintain the system at 35°C, start the homogenizer, and slowly pump in 50 parts by weight of the blood-activating oil phase prepared according to the method of Preparation Example 3. Set the high-shear disperser speed to 5000 rpm and continuously shear disperse for 15 minutes to obtain the primary emulsion.

[0093] S2. Using a high-precision dual metering pump, 180 parts by mass of the continuous phase of free calcium and alginate prepared according to the method of Preparation Example 6, maintained at 35°C, are simultaneously pumped into a line-type static mixer along with the primary emulsion at the same temperature. By adjusting the pump flow rate, the contact time between the two fluids in the static mixer is controlled to be 0.2 seconds.

[0094] S3. Directly introduce the mixed fluid exiting the static mixer into the inlet of the high-pressure homogenizer. Set the pressure drop of the primary homogenizing valve of the homogenizer to 45 MPa. The fluid is compressed under high pressure through the homogenizing valve, and through the adiabatic shear heating effect, the local temperature of the fluid instantly rises from 35°C to 65°C within the homogenizing valve. At the interface of the extreme shear force field and the high temperature trigger, anionic polysaccharides and calcium ions undergo instantaneous recombination and covalent coordination, forming a dense, layered encapsulation structure.

[0095] S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into the shell-and-tube heat exchanger within 3 seconds, and the system temperature is rapidly reduced to 25°C using ice water medium. Then, the dispersion is pumped into the ultra-high temperature instantaneous sterilization pipeline and held at 140°C for 3 seconds. After cooling, it is aseptically filled to obtain a medicinal and edible plant composition with the effect of promoting blood circulation and clearing the meridians.

[0096] Example 4:

[0097] This embodiment provides a method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, comprising the following steps:

[0098] S1. Add 400 parts by weight of the strong acidic pectin and saponin continuous phase prepared according to the method of Preparation Example 7 to a high-shear emulsification vessel equipped with a water bath jacket, add 200 parts by weight of purified water, and start stirring to mix evenly. Strictly control the jacket temperature to maintain the system at 32°C, start the homogenizer, and slowly pump in 40 parts by weight of the blood-activating oil phase prepared according to the method of Preparation Example 1. Set the high-shear disperser speed to 4000 rpm and continuously shear disperse for 12 minutes to obtain the primary emulsion.

[0099] S2. Using a high-precision dual metering pump, 200 parts by mass of the continuous phase of free calcium and alginate prepared according to the method of Preparation Example 4, maintained at 32°C, are simultaneously pumped into a line-type static mixer along with the primary emulsion at the same temperature. By adjusting the pump flow rate, the contact time between the two fluids in the static mixer is controlled to be 0.4 seconds.

[0100] S3. Directly introduce the mixed fluid exiting the static mixer into the inlet of the high-pressure homogenizer. Set the pressure drop of the first-stage homogenizing valve of the homogenizer to 42 MPa. The fluid is compressed under high pressure through the homogenizing valve, and through the adiabatic shear heating effect, the local temperature of the fluid instantly rises from 32°C to 62°C within the homogenizing valve. Under this thermodynamic boundary, the dechelation of calcium ions and the interfacial recombination of polysaccharide segments are completed.

[0101] S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into the shell-and-tube heat exchanger within 4 seconds, and the system temperature is rapidly reduced to 22°C using ice water medium. Then the dispersion is pumped into the ultra-high temperature instantaneous sterilization pipeline and held at 138°C for 4 seconds. After cooling, it is aseptically filled to obtain a medicinal and edible plant composition with the effect of promoting blood circulation and clearing the meridians.

[0102] Comparative Example 1:

[0103] Compared with Example 1, the difference is that a static mixer is not used for instantaneous mixing and isolation of the two-phase fluids. Instead, the free calcium and alginate continuous phase prepared according to the method of Preparation Example 4 is directly added to the emulsification tank and mixed with the primary emulsion for 20 minutes before entering the high-pressure homogenizer. All other aspects are the same.

[0104] Comparative Example 2:

[0105] Compared with Example 1, the difference is that the pressure drop of the first-stage homogenizing valve of the high-pressure homogenizer is set to 15 MPa, while the rest are the same.

[0106] Comparative Example 3:

[0107] Compared with Example 1, the difference is that no kelp raw material was added when preparing the continuous phase of free calcium and alginate, and an equal amount of purified water was used instead, while the rest were the same.

[0108] Comparative Example 4:

[0109] Compared with Example 1, the difference is that after the high-pressure homogenized fluid is drawn out and cooled to 25°C, the continuous phase prepared according to the method of Preparation Example 4 is slowly added dropwise, and the mixture is stirred at 500 rpm for 10 minutes. All other aspects are the same.

[0110] Comparative Example 5:

[0111] Compared with Example 1, the difference is that when preparing the blood-activating oil phase according to the method of Preparation Example 1, the step of scalding and peeling the raw peach kernels in boiling water is omitted. Instead, the raw peach kernels are directly mixed and pulverized with Angelica sinensis and then extracted with supercritical carbon dioxide. All other aspects are the same.

[0112] Comparative Example 6:

[0113] Compared with Example 1, the difference is that the hawthorn and ginseng components in the formula are removed and replaced with equal parts by mass of Tween-80 and xanthan gum as a conventional emulsification and thickening system, which is prepared using a conventional emulsification process. All other aspects are the same.

[0114] Test Example 1:

[0115] Test Description: This test aims to verify whether the mechanical heat generated by adiabatic shear during high-pressure homogenization can disrupt the pre-set dissolution equilibrium of the complex system, thereby triggering an in-situ crosslinking reaction through a thermodynamic switch. The experimental subject is the dynamic fluid from the preparation process in Example 1. To achieve precise capture of the physicochemical state within an extremely short time, the test is conducted using a pilot-scale continuous pipeline to avoid environmental temperature interference and phase recombination caused by conventional offline sampling.

[0116] Test steps:

[0117] 1. Based on the actual process pipeline route of Example 1, three online monitoring and sampling nodes are set up. Node 1 is fixed on the connecting short pipe from the outlet of the static mixer to the inlet of the high-pressure homogenizer. Node 2 is set on the ultra-short distance extension pipe section at the outlet of the high-pressure homogenizer valve. Node 3 is located in the outlet pipeline of the shell-and-tube heat exchanger.

[0118] 2. High-frequency response armored thermocouple temperature sensors are connected to the flanges of the above three characteristic nodes respectively, and the system is directly connected to a high-precision data acquisition card to synchronously record the instantaneous fluid temperature evolution trajectory under continuous and stable operation of the equipment.

[0119] 3. After the system has been running continuously for twelve minutes and the overall thermal balance has been confirmed, five milliliters of fluid samples are taken from the online high-pressure sampling valves at the above three nodes using the bypass design. To eliminate random errors caused by fluid pulsation, three independent sampling batches are set up for parallel determination.

[0120] 4. The obtained sample is immediately pumped into a closed flow detection cell equipped with a high-temperature resistant calcium ion selective electrode. Before the measurement, the pipeline automatically injects two microliters of high-concentration ion strength modifier into the sample to mask the potential interference of background ions. The system quickly reads the absolute concentration data of free calcium ions in the aqueous phase that have not yet participated in the cross-linking reaction within ten seconds, and to the greatest extent possible, prevents the secondary shift of the reverse solubility balance caused by natural cooling after the sample goes offline.

[0121] The test data is shown in Table 1.

[0122] Table 1: Data on instantaneous fluid temperature and free calcium ion concentration at various process nodes under different operating batches

[0123]

[0124] According to the appendix Figure 2As shown in Table 1, the fluid thermodynamic state during the high-pressure homogenization process exhibits a highly bound nonlinear response relationship with the ion coordination environment within the system. A common phenomenon was observed in three batches continuously monitored during the pilot-scale amplification phase: when the fluid entered the homogenizer at a typical room temperature range of 32°C, the concentration of free calcium ions in the aqueous phase generally remained at a relatively high threshold of approximately 2.0 mmol / L. This confirms that under this temperature condition, the chelation effect of citrate on polyvalent calcium ions has established a relatively stable dynamic equilibrium, ensuring that the free metal ions in the pipeline are insufficient to induce long-range cross-linking of polysaccharide macromolecules, thus eliminating the engineering hazard of high-viscosity materials clogging narrow valve bodies.

[0125] As materials advance through the production pipeline, in the extremely brief instant when the fluid is pumped by high pressure through the homogenizing valve to node two, extreme mechanical shearing and cavitation release generate a strong adiabatic temperature rise, forcibly pushing the local microscopic temperature above 60°C. Simultaneously with this thermodynamic abrupt change, the concentration of free calcium ions in the system experiences a precipitous drop, plummeting to below 0.35 mmol / L. This dramatic consumption of free metal ions is not a mere accidental measurement error. From a fundamental physical chemistry perspective, it is precisely because the complex complex system, after crossing a specific critical temperature, triggers a rare reverse solubility switch. Calcium ions, originally stabilized and masked by citric acid, are forced to undergo phase separation and release under thermal drive. They are then immediately captured by the alginate-guluronic acid fragments and low-ester pectin backbone free at the nascent oil-water interface, instantly completing the coordination cross-linking and shaping of a typical egg-box structure in a strongly turbulent flow field.

[0126] After being forcibly cooled to room temperature by the ice-water heat exchanger at node three, the free calcium concentration curve no longer rebounded but continued to oscillate slightly at an extremely low level, confirming that the interfacial polymerization reaction that broke out within the temperature rise window was irreversible.

[0127] Test Example 2:

[0128] Test Description: This test primarily verifies the contribution of in-situ cross-linking structures at the interface to the long-term physical stability of the dispersion system. Experimental subjects include Examples 1 to 4 and Comparative Examples 1 to 4. By quantifying fluid dynamics parameters and accelerated centrifugation sedimentation data, the impact of spatially isolated mixing and in-situ microencapsulation on product quality is elucidated.

[0129] Test steps:

[0130] 1. During the continuous preparation process, an online rotational viscometer installed at the inlet of the high-pressure homogenizer was used to record the initial viscosity of Examples 1 to 4 and Comparative Examples 1 to 4 after the two-phase fluid was mixed in real time. The pressure fluctuation frequency of the high-pressure pump and the operating status of the homogenizing valve were also observed and recorded to evaluate the pipeline passability of the material and the equipment tolerance.

[0131] 2. Collect the finished dispersions of each group after preparation. Take 10 ml of each sample and inject it into a transparent test centrifuge tube. Use a full-function stability analyzer to conduct accelerated sedimentation experiments at 25°C. Set the centrifugation speed to 4000 rpm and scan the near-infrared transmittance trajectory of the sample tube every 30 seconds.

[0132] 3. Use the accompanying analysis software to integrate the transmittance evolution curves and calculate the centrifugal instability index of each group of samples after an equivalent one-year storage time at room temperature. The closer the value is to 0, the more stable the system is; the closer it is to 1, the more complete phase separation has occurred.

[0133] 4. Perform macroscopic observation on the samples after centrifugation test, and record whether there is hard precipitate at the bottom of each group of samples and whether there is obvious oil droplet aggregation and precipitation at the top.

[0134] The test data is shown in Table 2.

[0135] Table 2: Summary of Engineering Feasibility Indicators and Centrifugation Instability Test Results for Each Experimental Group

[0136]

[0137] According to the appendix Figure 3 Based on the data in Table 2, observations of the field operation in Comparative Example 1 revealed that after canceling the extremely short contact setting of the static mixer, the fluid underwent prolonged in-vessel mixing before entering the high-pressure pump. This caused calcium ions to slowly leak from the chelate network of citric acid, directly forming extensive macroscopic cross-links with alginic acid and pectin. The dramatic changes in rheological data confirmed this process, with the material viscosity increasing from the normal range of hundreds of millipascals to 1438.6 millipascals. This triggered severe pulsation in the homogenizer's high-pressure pump, and gel clumps formed compressive blockages at the narrow valve orifice, demonstrating that without physical spatial isolation control, continuous production relying on reverse solubility switches was unsustainable.

[0138] The centrifugal instability indices of Examples 1 to 4 were all suppressed to below 0.06, indicating that a dense, rigid network had been constructed on the oil droplet surface under the combined effects of strong shear and thermodynamic intervention. In contrast, Comparative Example 2, due to insufficient homogenization pressure, failed to raise the fluid temperature above the phase transition critical point, making it difficult for free calcium to be fully released. Its instability index jumped to 0.412, accompanied by significant oil phase precipitation. Combined with the test results of Comparative Example 4, the conventional model tends to generate spontaneously settling flocs in the continuous phase rather than directionally adhering to the oil-water interface. This spatial misalignment makes its stability far inferior to the in-situ crosslinked system. Example 3 obtained an optimal instability index of 0.038 by fine-tuning the homogenization pressure drop, reflecting the promoting effect of extreme physical fields on the stretching and coordination of polysaccharide molecular chains.

[0139] Test Example 3:

[0140] Test Description: This test aims to quantitatively evaluate the physical barrier and protective efficacy of the in-situ cross-linked interfacial structures constructed by each component against volatile and easily oxidized active ingredients in the oil phase of medicinal and edible homologous products. Examples 1 to 4, Comparative Example 3, and Comparative Example 6 were selected as experimental subjects.

[0141] Test steps:

[0142] 1. Take three parallel samples from each group of freshly prepared dispersions and take the average value. Dispense each sample into multiple 20 ml brown headspace vials, seal them with nitrogen, and place them in a constant temperature and humidity chamber set at 40℃±1℃ and 75%±5% relative humidity for accelerated aging storage.

[0143] 2. Set sampling time points as day 0, day 15, and day 30. At the predetermined time points, remove the corresponding batch of sample vials, allow them to return to room temperature, add excess anhydrous methanol to the vials, and place them in an ultrasonic cleaner for 30 minutes of high-frequency demulsification extraction to ensure that the oil phase components encapsulated in microcapsules are completely released into the organic solvent phase.

[0144] 3. The extract was filtered through a 0.22-micron microporous membrane and then injected into a high-performance liquid chromatograph. Chromatographic conditions included a C18 reversed-phase column, an acetonitrile-water gradient elution system as the mobile phase, and a detection wavelength of 280 nm. The characteristic unstable component ligustilide from Angelica sinensis and Ligusticum chuanxiong was used as the core indicator.

[0145] 4. Record the peak area of ​​ligustilide in the chromatogram and substitute it into the standard curve to calculate its absolute content. Using the measurement value on day 0 as the baseline, calculate the component retention rate on day 15 and day 30 to represent the blocking ability of the micro-interface membrane for active molecules and the antioxidant barrier effect.

[0146] The test data is shown in Table 3.

[0147] Table 3: Changes in the retention rate of ligustilide in each dispersion during accelerated storage at 40℃

[0148]

[0149] According to the appendix Figure 4 According to the data in Table 3, under the 30-day high-temperature accelerated test, the retention rate of ligustilide in Example 3 was still as high as 94.38%. This data, together with Example 1 and Example 4, constitutes a highly stable data cluster. The in-situ crosslinking reaction induced by high-pressure homogenization formed a dense and rigid polymer network on the surface of the oil droplets, which blocked the outward escape path of volatile molecules in the oil phase and significantly reduced the mass transfer coefficient of ambient oxygen diffusion into the oil core chemically.

[0150] Comparative Example 3, lacking a crucial calcium ion crosslinking agent, could not form a rigid interfacial film, relying solely on the weak physical adsorption of pectin and saponins to maintain emulsification. Under thermal stress at 40°C, Brownian motion at the oil-water interface intensified, leading to the disintegration of the protective layer. Ligusticolone was directly exposed to dissolved oxygen in the aqueous phase, and its retention rate dropped to 63.29% within 30 days, confirming that simple physical mixing is insufficient to address the oxidative degradation of active ingredients.

[0151] Comparative Example 6 uses the classic industrial formula of "Tween-80 + xanthan gum," and its retention rate of 74.16% is better than that of the unprotected Comparative Example 3, but still lower than that of the embodiments of the present invention. The reason why Example 3 can obtain the best data is due to its higher homogenization pressure and the reverse solubility phase transition caused by the instantaneous temperature rise, which promotes the maximization of the cross-linking density of calcium ions and polysaccharide segments at the interface.

[0152] Test Example 4:

[0153] Test Description: This test aims to verify whether different systems, after undergoing high-intensity mechanical pulverization and thermodynamic intervention, can control the characteristic toxic compounds endogenously associated with natural plant matrices within safe thresholds. The experimental subjects include the final dispersion products of Examples 1 to 4 and Comparative Example 5.

[0154] Test steps:

[0155] 1. Take the finished dispersion solution that has just been aseptically filled from each group, accurately pipette 5 ml of sample into a 20 ml headspace vial in a low-temperature fume hood, quickly add 1 ml of 10% dilute sulfuric acid solution to the vial to destroy any possible complexed cyanide, and then seal it with an aluminum cap with a polytetrafluoroethylene silicone septum.

[0156] 2. Place the sealed sample vial into the heating furnace of the fully automated headspace sampler, set the equilibrium temperature to 80 degrees Celsius, and incubate statically for 45 minutes. During this period, the cyanogenic glycoside derivatives and free hydrogen cyanide in the sample system will fully volatilize under acidic heating conditions, achieving gas-liquid two-phase equilibrium.

[0157] 3. The headspace gas inside the vial is quantitatively pumped into the gas chromatograph via a heated transfer line. Chromatographic separation is performed using a weakly polar capillary column, with high-purity helium as the carrier gas. The programmed temperature is set to start at 40 degrees Celsius and hold for two minutes, then increase to 120 degrees Celsius at a rate of 10 degrees Celsius per minute.

[0158] 4. The specific response of the eluted target components was monitored using a nitrogen-phosphorus detector. The peak area at specific retention times in the chromatogram was recorded. The absolute residual amount of hydrogen cyanide in each batch of samples was calculated using the external standard method combined with a standard curve. Three parallel batches of each sample were determined independently to eliminate injection error.

[0159] The test data is shown in Table 4.

[0160] Table 4: Data on the determination of residual hydrocyanic acid in the finished dispersions of each group

[0161]

[0162] According to the data in Table 4, the comparative sample 5, by omitting the basic step of blanching and peeling raw peach kernels in boiling water and directly crushing and extracting them, resulted in no inhibition of enzyme activity, leading to a final cyanide residue level of 18.47 mg / kg in the dispersion. This level of residue far exceeds the safety limits for related food and medicine homologous matrices in the pharmacopoeia, and poses a potential occupational health hazard to enclosed pipeline equipment and on-site operators during the high-temperature homogenization and sterilization stages.

[0163] The test results of Examples 1 to 4 show that when fresh-cut peach kernels are subjected to the thermal shock of boiling water during the preparation stage, the high temperature forces the three-dimensional conformation of the amygdalin protein to undergo irreversible denaturation and folding, thus severing the enzymatic reaction chain of cyanogenic glycosides at its source. Even with the introduction of homogeneous shear and adiabatic temperature rise of 45 MPa in subsequent processes, the catalytic base has been completely destroyed, preventing the spontaneous synthesis of new toxic products within the microscopic system. The residual amount of hydrocyanic acid in the products of each example is locked near an extremely low baseline of 0.11 to 0.16 mg / kg, which is essentially equivalent to the background fluctuations detected by gas chromatography or the trace amounts of naturally occurring free state traces associated with the raw material surface.

[0164] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A medicinal and edible plant composition with blood-activating and meridian-clearing effects, characterized in that, Made from raw materials comprising the following parts by weight: Strongly acidic pectin and saponin continuous phase: 250-400 parts; Purified water: 200-350 parts; Blood-activating oil phase: 20-50 parts; Free calcium and alginic acid continuous phase: 130-200 parts.

2. The medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 1, characterized in that, The blood-activating oil phase is made from raw peach kernels and sliced ​​angelica, with the mass ratio of raw peach kernels to sliced ​​angelica being 1:1 to 3.

3. The medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 1, characterized in that, The strongly acidic pectin and saponin continuous phase is made from hawthorn slices, ginseng slices and extraction solvent, wherein the mass ratio of hawthorn slices to ginseng slices is 3-6:1; and the pH value of the strongly acidic pectin and saponin continuous phase is 3.5-4.

5.

4. The medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 1, characterized in that, The free calcium and alginate continuous phase is made from dried kelp and purified water, wherein the mass ratio of dried kelp to purified water is 1:15-20.

5. A method for preparing a medicinal and edible plant composition with blood-activating and meridian-clearing effects, used to prepare the medicinal and edible plant composition with blood-activating and meridian-clearing effects as described in any one of claims 1-4, characterized in that: S1. Add strong acidic pectin and saponin continuous phase and purified water to a high-shear emulsification kettle with a water bath jacket, start stirring and mix evenly, control the jacket temperature to maintain the system constant temperature, start the homogenizer and slowly pump in the blood-activating oil phase, and continuously shear and disperse to obtain the primary emulsion. S2. Free calcium and alginate are continuously pumped into the primary emulsion at the same temperature into a pipeline static mixer, and the fluid contact time is controlled to obtain a mixed fluid in a low viscosity state. S3. The mixed fluid flowing out of the static mixer is directly introduced into the inlet of the high-pressure homogenizer. The fluid is squeezed under high pressure by the homogenizer valve and instantly heated by the adiabatic shear heating effect, triggering the reverse solubility characteristic to release free calcium ions, which then undergo in-situ cross-linking on the surface of the oil droplets. S4. The dispersion flowing out of the high-pressure homogenizing valve is forcibly introduced into the heat exchanger to rapidly reduce the system temperature to lock the cross-linking structure. Then, it is pumped into the ultra-high temperature instantaneous sterilization pipeline, cooled down, and aseptically filled to obtain the medicinal and edible plant composition.

6. The method for preparing the medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 5, characterized in that, Before step S1, the pretreatment and preparation method of the blood-activating oil phase is as follows: Blanch the raw peach kernels in boiling water at 95-100℃ for 5-10 minutes, then immediately immerse them in purified water at 5-10℃ for rapid cooling and mechanical peeling. Peeled peach kernels and sliced ​​angelica are mixed and crushed, and placed in a supercritical carbon dioxide extraction vessel. Extraction is carried out for 2 to 4 hours under the conditions of extraction pressure of 25 to 35 MPa and extraction temperature of 40 to 50°C. After decompression, the fat-soluble mixture is collected for later use.

7. The method for preparing the medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 5, characterized in that, The preparation method of the strong acid pectin and saponin continuous phase includes: mixing hawthorn slices and ginseng slices, adding purified water, extracting at a constant temperature of 70-80℃ for 1.5-2.5 hours, filtering, and then concentrating under negative pressure to 1 / 3 to 1 / 2 of the original extract mass for later use. The preparation method of the free calcium and alginic acid continuous phase includes: pulverizing dried kelp and adding purified water, stirring and extracting at a constant temperature of 50-60℃ for 2-3 hours, centrifuging and separating the supernatant and filtering it through a microporous membrane with a pore size of 0.2-0.45 micrometers for later use.

8. The method for preparing the medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 5, characterized in that, Step S1 further includes: Strictly control the system temperature to be maintained between 30 and 35°C; Set the high-shear disperser speed to 3000-5000 rpm and the continuous shear dispersion time to 10-15 minutes.

9. The method for preparing the medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 5, characterized in that, In step S2, the free calcium and alginate continuous phase are simultaneously pumped into the primary emulsion at the same temperature into a pipeline static mixer, and the fluid contact time is controlled to be 0.2 to 0.5 seconds. In step S3, the pressure drop of the primary homogenizing valve of the high-pressure homogenizer is 35-45 MPa, causing the local temperature of the fluid to rise instantaneously from 30-35°C to 55-65°C within the homogenizing valve.

10. The method for preparing the medicinal and edible plant composition with blood-activating and meridian-clearing effects according to claim 5, characterized in that, In step S4, the dispersion is forcibly introduced into the heat exchanger within 3 to 5 seconds to lower the system temperature to 20 to 25°C; the conditions for ultra-high temperature instantaneous sterilization are: maintaining at 135 to 140°C for 3 to 5 seconds.

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