A Chinese medicine combination drug for treating burns, scalds and refractory wounds and a preparation method of a plaster of the Chinese medicine combination drug

Abstract

The application discloses a traditional Chinese medicine combined medicament for treating burns and scalds and refractory wounds and a preparation method of a plaster of the medicament, relates to the technical field of traditional Chinese medicine, and aims to solve the technical problem that a single dosage form of a traditional Chinese medicine preparation for treating burns and scalds cannot simultaneously cover the whole treatment stage of analgesia, deputrescence and skin regeneration, and the combined medicament comprises a traditional Chinese medicine plaster and a traditional Chinese medicine powder, the traditional Chinese medicine plaster is prepared from rhubarb and sanguisorba officinalis as monarch drugs, radix rehmanniae, lithospermum erythrorhizon, safflower, frankincense and myrrh as ministerial drugs, edible sesame oil and beeswax as a base to form an external oil ointment, and has the functions of deputrescence and skin regeneration, blood cooling and stasis removal, inflammation reduction and pain relief, the traditional Chinese medicine powder is prepared from oyster shell and cinnabar as monarch drugs, panax notoginseng as a ministerial drug and rhubarb as an auxiliary drug to form an external powder preparation, and has the functions of rapid pain relief, skin regeneration and convergence, and bacterium inhibition and infection resistance, and when the two are used in combination, the traditional Chinese medicine powder is uniformly spread on the surface of a wound, and then the traditional Chinese medicine plaster is uniformly applied and covered on the outer layer of the powder.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine pharmaceutical technology, specifically relating to a combination of traditional Chinese medicines for treating burns and scalds and difficult-to-heal wounds, and a method for preparing its ointment. Background Technology

[0002] Burns and scalds, as well as various slow-healing wounds (such as pressure ulcers, diabetic foot ulcers, and postoperative infected wounds), are common trauma diseases in clinical practice. Improper treatment can easily lead to wound infection and prolonged healing, and in severe cases, can cause scar hyperplasia or systemic infection. Currently, most traditional Chinese medicine treatments for burns and slow-healing wounds are single-dose formulations, which cannot simultaneously cover the full treatment needs of "pain relief, necrotic tissue removal, and tissue regeneration."

[0003] Jingwanhong Ointment (National Drug Approval Number Z12020440) is an ointment made with sesame oil and beeswax as a base. It has the effects of promoting blood circulation, detoxifying, removing necrotic tissue, and promoting tissue regeneration. Clinically, it is used to treat mild burns and ulcers. However, this is a single ointment formulation, and its analgesic effect is relatively slow, making it difficult to quickly relieve acute pain. The oily base can easily cause wound maceration in deep wounds with large exudates, increasing the risk of secondary infection. Its efficiency in removing necrotic tissue and promoting tissue regeneration in difficult wounds such as severe burns, bedsores, and diabetic foot is limited, and the overall healing period is relatively long. Moist Burn Ointment is also a single ointment formulation, based on the theory of moist healing, for burn wound care. However, its analgesic effect in the acute phase is delayed, and the ointment is greasy and thick, which can easily block the exudate channels of the wound. If the wound is not thoroughly cleaned, it can easily cause necrotic tissue retention. Its effect on promoting granulation tissue growth at the wound base is limited, and the healing period for deep wounds is relatively long. Chinese patent CN103099962B discloses a traditional Chinese medicine powder for treating burns and scalds. This powder, made from herbs such as Sanguisorba officinalis, Coptis chinensis, Bletilla striata, Sophora flavescens, and Gardenia jasminoides, is pulverized and sterilized to form an external powder, focusing on astringency, hemostasis, and tissue regeneration. However, this is a single-powder formulation, with relatively weak effects in removing necrotic tissue, clearing blood stasis, cooling the blood, and reducing inflammation. The powder adheres poorly to wounds with significant exudation, easily being washed away by the exudate, resulting in a short duration of efficacy. It also lacks wound-moisturizing properties and has a slow onset of pain relief. In summary, existing single-form burn and scald treatments all have functional limitations and cannot simultaneously achieve rapid pain relief, efficient necrotic tissue removal, and rapid tissue regeneration throughout the entire treatment process. Summary of the Invention

[0004] The purpose of this invention is to provide a combination of traditional Chinese medicine ointment and powder for treating burns and scalds and difficult-to-heal wounds, in order to solve the following technical problems existing in the prior art: existing treatments for burns and scalds and difficult-to-heal wounds are mostly single-dosage forms. Single ointment dosage forms have a slow onset of analgesia and are difficult to quickly relieve severe pain in the acute phase. The oily matrix can easily cause wound maceration in deep wounds with large exudates, increasing the risk of secondary infection. Single powder dosage forms have weak effects in removing necrotic tissue, removing blood stasis, cooling blood and reducing inflammation. The powder has poor adhesion to wounds with large exudates, the duration of efficacy is short, and it lacks wound moisturizing effect. Existing single dosage forms cannot simultaneously cover the needs of the entire treatment stage of "pain relief - necrotic tissue removal - tissue regeneration". The overall treatment effect on difficult-to-heal wounds such as severe burns, bedsores, and diabetic foot ulcers is significantly limited, and the treatment process is painful for patients and the wound healing period is long.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: This invention provides a traditional Chinese medicine combination for treating burns and scalds, as well as difficult-to-heal wounds, comprising a traditional Chinese medicine ointment and a traditional Chinese medicine powder. The ointment uses rhubarb and sanguisorba officinalis as the principal herbs, and rehmannia glutinosa, gromwell root, saffron, frankincense, and myrrh as the assistant herbs, with edible sesame oil and beeswax as the base to form a topical ointment. It is used to remove necrotic tissue and promote tissue regeneration, cool the blood and remove blood stasis, reduce inflammation and relieve pain, clear necrotic tissue from the wound, reduce local inflammation, repair the basal tissue of the wound, and create conditions for granulation tissue growth. The powder uses dragon bone and red ochre as the principal herbs, notoginseng as the assistant herb, and rhubarb as the adjuvant herb to form a topical powder preparation. It is used to quickly relieve pain, promote tissue regeneration, inhibit bacteria and fight infection, rapidly alleviate wound pain, promote granulation tissue growth, and accelerate wound healing. When using the ointment and powder together, first evenly sprinkle the powder on the wound surface, then evenly apply the ointment over the powder. The oily matrix covering layer of the ointment plays a sealing and protective role, fixing and prolonging the adhesion time of the powder on the wound. This allows the two dosage forms to form a functionally superimposed drug delivery layer on the wound. The powder first comes into direct contact with the wound to exert a rapid analgesic and astringent effect, while the ointment, after covering the wound, further exerts a debridement and wound-moistening effect. The two complement each other and work synergistically, breaking through the limitations of traditional single Chinese medicine dosage forms that cannot simultaneously cover the entire treatment stage.

[0006] Furthermore, the weight parts of each component in the herbal ointment are as follows: rhubarb 5-15 parts, Sanguisorba officinalis 5-15 parts, Rehmannia glutinosa 10-25 parts, Lithospermum erythrorhizon 8-20 parts, saffron 1-10 parts, frankincense 5-15 parts, myrrh 5-15 parts, beeswax 10-25 parts, and edible sesame oil 80-160 parts.

[0007] Preferably, the herbal ointment further includes 15-35 parts of calcined gypsum and 1-5 parts of borneol as adjuvants. Calcined gypsum has the effects of astringing and promoting tissue regeneration, clearing heat and stopping bleeding; borneol has the effects of clearing heat and relieving pain, opening the orifices and promoting penetration, and can guide the medicine to penetrate deep into the wound, enhancing the overall analgesic and penetrating effect. The two together serve as adjuvants, further improving the efficacy system of the ointment.

[0008] Specifically, the weight parts of each component in the Chinese herbal powder are: 20-40 parts of dragon bone, 20-40 parts of red ochre, 10-25 parts of Panax notoginseng, and 10-30 parts of rhubarb.

[0009] Furthermore, when the herbal ointment and the herbal powder are used together, the dressing should be changed 1 to 2 times a day depending on the depth of the wound and the amount of exudation, until the wound is completely healed.

[0010] Furthermore, in the preparation of the herbal ointment, during the final stage, the ointment is cooled to 55-65°C before saffron is added. The mixture is then soaked at this temperature for 2-4 hours, after which the saffron residue is filtered out. This process prevents the active ingredients of saffron from being deactivated during the high-temperature oil extraction stage, effectively preserving the effective content of the blood-activating and stasis-removing components of saffron.

[0011] Preferably, during the preparation of the herbal ointment, the borneol powder is added after the ointment is cooled to 45-50°C, and then quickly stirred until completely dispersed. This process prevents the loss of borneol due to volatilization at high temperatures, effectively preserving the analgesic and orifice-opening active ingredients of borneol.

[0012] Furthermore, in the preparation of the herbal ointment, rhubarb, sanguisorba officinalis, rehmannia glutinosa, and gromwell are soaked in edible sesame oil for 12 to 24 hours. Then, the oil is heated to 110 to 120°C and kept at that temperature for 30 to 60 minutes. The temperature is then increased to 125 to 135°C and simmered until the surface of the herbs turns dark brown and the inside is charred but not carbonized. Heating is then stopped.

[0013] Specifically, in the preparation process of the traditional Chinese medicine powder, the dragon bone and red ochre are crushed and calcined in a high-temperature furnace. After cooling, they are coarsely pulverized and passed through a 60-mesh sieve. Then, they are mixed with Panax notoginseng and rhubarb according to the prescription ratio and finely pulverized and passed through a 150-mesh sieve to obtain the mixed powder.

[0014] This invention also provides a method for preparing a traditional Chinese medicine ointment for treating burns and scalds and difficult-to-heal wounds, comprising the following steps: soaking rhubarb, sanguisorba officinalis, rehmannia glutinosa, and gromwell root in edible sesame oil, then heating and simmering the oil. First, heat the oil to 110-120°C and maintain the temperature for 30-60 minutes, then continue heating to 125-135°C until the surface of the medicinal materials is dark brown and the inside is charred but not carbonized. Filter out the dregs to obtain the medicinal oil. Heat the medicinal oil to 85-95°C, add beeswax and stir until melted, add calcined gypsum powder, frankincense, and myrrh powder and stir evenly, then cool to 55-65°C and add saffron. Maintain the temperature and soak for 2-4 hours, then filter out the saffron dregs. Cool the ointment to 45-50°C, add borneol powder and stir quickly until completely dispersed, cool and stand, then sterilize and package.

[0015] Compared with the prior art, the present invention has the following beneficial effects: 1. By combining traditional Chinese medicine powder and traditional Chinese medicine ointment, and using the order of administration of powder first and ointment later, the two complement each other and work synergistically. This overcomes the technical deficiency of existing single dosage forms that cannot simultaneously cover the needs of the entire treatment stage of "pain relief - necrotic tissue removal - tissue regeneration". It achieves synergistic therapeutic effects of rapid pain relief, anti-inflammatory and necrotic tissue removal, tissue regeneration and repair, and anti-infection, and greatly reduces the pain of patients during treatment and dressing changes.

[0016] 2. By combining the decomposing and blood-cooling effects of ointment with the tissue-regenerating and wound-closing effects of powder, inflammation can be reduced, necrotic tissue can be sloughed off, and granulation tissue can grow simultaneously. This effectively shortens the healing time of burns and various difficult-to-heal wounds, overcoming the technical shortcomings of existing single-dosage formulations, which have limited efficiency in decomposing and tissue-regenerating effects and have a longer healing cycle for deep wounds.

[0017] 3. Through the synergistic effect of the natural antibacterial and anti-inflammatory components of multiple Chinese herbs in ointments and powders, it has the dual effects of removing necrotic tissue and blood stasis, as well as inhibiting bacteria and fighting infection. It can effectively reduce the risk of wound infection and reduce dependence on antibiotics.

[0018] 4. By employing a low-temperature soaking process for saffron and a low-temperature addition process for borneol during the preparation of the ointment, the effective content of the blood-activating and stasis-removing components of saffron and the analgesic and orifice-opening components of borneol is effectively preserved, ensuring the integrity of the ointment's effective components.

[0019] 5. The combination of drugs in this invention is applicable to burns of different degrees, as well as various chronic and difficult-to-heal wounds such as bedsores, diabetic foot ulcers, and non-healing wounds after surgery. During the treatment, the wound is less irritated, the patient experiences less pain, and the probability of scar formation after healing is reduced, making it highly clinically adaptable. Detailed Implementation

[0020] The present application will now be described in further detail with reference to the embodiments. It should be understood that the following embodiments are used to illustrate the technical solutions of the present application, and are not intended to limit the scope of protection of the present application.

[0021] This invention provides a traditional Chinese medicine combination for treating burns and scalds, as well as wounds that are difficult to heal. It consists of two dosage forms: a traditional Chinese medicine ointment and a traditional Chinese medicine powder, which are prepared separately and used in combination. The ointment uses rhubarb and sanguisorba officinalis as the principal herbs, and rehmannia glutinosa, gromwell root, saffron, frankincense, and myrrh as the assistant herbs, with edible sesame oil and beeswax as the base to form an external ointment. Its primary functions are to remove necrotic tissue and promote tissue regeneration, cool the blood and remove blood stasis, and reduce inflammation and pain. The powder uses dragon bone and red ochre as the principal herbs, notoginseng as the assistant herb, and rhubarb as the adjuvant herb to form an external powder preparation. Its primary functions are to rapidly relieve pain, astringe and promote tissue regeneration, and inhibit bacteria and fight infection. The two dosage forms complement each other, synergistically covering the entire treatment stage of "pain relief—necrotic tissue removal—tissue regeneration."

[0022] In one feasible implementation, the prescription composition of the traditional Chinese medicine ointment is as follows: The principal ingredient is rhubarb (5-15 parts) and sanguisorba officinalis (5-15 parts). Rhubarb has the effects of purging heat and detoxifying, cooling blood and removing blood stasis, and removing putrefaction and draining pus. Sanguisorba officinalis has the effects of cooling blood and stopping bleeding, and clearing heat and detoxifying. The two ingredients work synergistically to guide the core effects of the ointment in removing putrefaction and cooling blood. The assistant ingredients are rehmannia glutinosa (10-25 parts), gromwell root (8-20 parts), saffron (1-10 parts), frankincense (5-15 parts), and myrrh (5-15 parts). Rehmannia glutinosa clears heat, cools blood, and nourishes yin; gromwell root cools blood and invigorates blood. Blood-activating and stasis-removing herbs include saffron, frankincense, and myrrh, which invigorate blood circulation, relieve pain, reduce swelling, and promote tissue regeneration. These five herbs work synergistically with the principal herbs to enhance their effects of removing necrotic tissue, removing blood stasis, reducing swelling, and relieving pain. The adjuvant herbs include 15-35 parts calcined gypsum and 1-5 parts borneol. Calcined gypsum has astringent, tissue-regenerating, heat-clearing, and hemostatic effects, while borneol has heat-clearing, pain-relieving, and orifice-opening effects, which can guide the medicine deeper into the wound. The matrix excipients include 80-160 parts edible sesame oil and 10-25 parts beeswax. Edible sesame oil serves as an extraction solvent and wound-moistening matrix, while beeswax is used to adjust the consistency of the ointment.

[0023] The preparation process of traditional Chinese medicine ointments includes the following steps: Step 1: Pre-processing of medicinal materials. Remove impurities from rhubarb, sanguisorba officinalis, rehmannia glutinosa, and gromwell root, wash them, soak them thoroughly, cut them into thick slices, and dry them in a low-temperature drying device, controlling the moisture content to not exceed 8%. Remove impurities from saffron and air-dry it for later use. Remove impurities from frankincense and myrrh, soften them by baking, cut them into small pieces, press out some of the oil, and grind them into coarse powder for later use. Grind calcined gypsum into powder and pass it through a 120-mesh sieve for later use. Grind borneol separately into a fine powder, seal it, and store it at a low temperature for later use.

[0024] Step 2, sesame oil soaking. Place the prescribed amount of edible sesame oil in a clean oil-making container, add rhubarb, burnet root, rehmannia root, and purple gromwell root, stir well to ensure the herbs are completely immersed in the oil, and seal and soak for 12-24 hours.

[0025] Step 3: Segmented temperature control for oil extraction. After soaking, slowly heat the oil, first raising it to 110-120℃ and maintaining it for 30-60 minutes; then continue heating to 125-135℃ and continue simmering until the surface of the medicinal material turns dark brown and the inside is charred but not carbonized, then stop heating.

[0026] Step 4: Oil Filtration and Sedimentation. Filter out the medicinal residue while hot using a 120-mesh filter to obtain medicinal oil. Let the medicinal oil stand for at least 12 hours to allow fine impurities at the bottom to settle naturally, and then collect the clear medicinal oil from the top for later use.

[0027] Step 5: Completing the Ointment and Adding Other Ingredients. Reheat the clarified medicinal oil to 85-95℃, add beeswax, and stir until completely melted; then add finely powdered calcined gypsum and stir evenly; next, add coarse powdered frankincense and myrrh, and continue stirring until evenly dispersed. Cool the ointment to 55-65℃, add saffron, and maintain the temperature for soaking for 2-4 hours to allow the active ingredients of saffron to fully dissolve, then filter out the saffron residue. The active ingredients of saffron are easily deactivated at high temperatures; soaking at a lower temperature of 55-65℃ can effectively preserve the effective content of its blood-activating and stasis-removing components.

[0028] Step Six: Cool and Add Borneol. Continue cooling the ointment to 45-50℃, add finely powdered borneol, and stir quickly until completely dispersed. Borneol is easily lost due to volatilization at high temperatures. Adding it at a lower temperature of 45-50℃ and stirring quickly can effectively retain the analgesic and sedative components of borneol.

[0029] Step 7: Settling and Packaging. Allow the ointment to cool naturally to room temperature, seal and let it stand for 12–24 hours to allow the texture of the ointment to stabilize and become uniform. Then heat it to 50–60°C to restore the fluidity of the ointment. After sterilization, package it into pharmaceutical tubes or sterile containers and seal them to obtain the finished herbal ointment.

[0030] In one feasible implementation, the prescription composition of the traditional Chinese medicine powder is as follows: The principal ingredient, dragon bone (20-40 parts), and red ochre (20-40 parts), have the effects of astringing, consolidating, calming, and relieving pain, while red ochre has the effects of astringing, stopping bleeding, promoting tissue regeneration, and healing sores. The two ingredients work synergistically to achieve the core effects of rapid pain relief and astringency in the powder; the assistant ingredient, Panax notoginseng (10-25 parts), has the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain, stopping bleeding, and promoting tissue regeneration, assisting the principal ingredient in enhancing its hemostatic, analgesic, and granulation tissue growth effects; and the adjuvant ingredient, rhubarb (10-30 parts), has the effects of purging heat and detoxifying, cooling blood and reducing inflammation, assisting the principal ingredient in exerting its antibacterial and anti-infective effects.

[0031] The preparation process of traditional Chinese medicine powder includes the following steps: Step 1: Pre-processing of medicinal materials. Remove impurities from raw rhubarb, wash, slice, and dry at a low temperature, controlling the moisture content to no more than 6%. Remove impurities from Panax notoginseng, wash, and dry for later use. Remove impurities from dragon bone and red ochre, crush, calcine in a high-temperature furnace, and then cool for later use. Dragon bone and red ochre are mineral medicines; calcination in a high-temperature furnace makes them brittle, facilitating subsequent pulverization, and also removes organic impurities, improving the purity of the medicine.

[0032] Step 2, Grinding and Sieving. The above-mentioned medicinal materials are coarsely ground and passed through a 60-mesh sieve; then, the powders are mixed according to the prescription ratio and finely ground and passed through a 150-mesh sieve to obtain mixed powder.

[0033] Step 3: Mixing and Grinding. The mixed powders are further ground and mixed using an equal-incremental method until the powder has a uniform color, no obvious patterns, and no agglomerated particles.

[0034] Step 4, dry heat sterilization. Spread the evenly mixed powder evenly in a sterile tray, ensuring the thickness does not exceed 5mm, and sterilize using dry heat sterilization.

[0035] Step 5: Granulation and Packaging. After sterilization, allow the powder to cool to room temperature and then granulate it again through a 150-mesh sieve. In a clean environment, package the powder into sterile pharmaceutical plastic bottles and seal them to obtain the finished traditional Chinese medicine powder.

[0036] When used in combination, after routine wound cleaning and disinfection, first evenly sprinkle the herbal powder onto the entire wound surface, then evenly apply the herbal ointment over the powder. This order of administration—powder first, ointment later—allows the powder to directly contact the wound, allowing the astringent and analgesic components such as dragon bone and red ochre to quickly act on the wound, exerting a rapid analgesic and astringent effect. The subsequent application of the ointment over the powder forms a protective, sealing layer, fixing the powder to the wound surface and prolonging its effective duration. Simultaneously, the ointment's own components for removing necrotic tissue, promoting tissue regeneration, cooling the blood, and removing blood stasis continue to act on the wound, further enhancing its wound-moistening and healing effects. The two dosage forms create a functionally superimposed treatment layer on the wound, synergistically achieving coverage of the entire treatment stage: pain relief, necrotic tissue removal, and tissue regeneration.

[0037] Depending on the depth and amount of exudate, change the dressing 1-2 times daily until the wound is completely healed. For deep wounds with significant exudate or acute wounds, the frequency of dressing changes can be increased to twice daily to maintain an effective drug concentration. For wounds in the recovery phase with less exudate, changing the dressing once daily is sufficient to reduce interference with newly formed granulation tissue and help accelerate wound healing.

[0038] Where there is no conflict, the technical features of the above embodiments can be combined with each other. The dosage of each component of the ointment and powder can be appropriately adjusted according to the type and severity of the wound within the scope disclosed in this application, without changing the core technical solution of synergistic drug delivery of the two dosage forms.

Claims

1. A traditional Chinese medicine combination for treating burns and scalds, and wounds that are difficult to heal, characterized in that, This includes traditional Chinese medicine ointments and powders. The ointment uses rhubarb and sanguisorba officinalis as the principal ingredients, and rehmannia glutinosa, gromwell root, saffron, frankincense, and myrrh as the assistant ingredients, with edible sesame oil and beeswax as the base to make an external ointment, which is used to remove necrotic tissue and promote tissue regeneration, cool the blood and remove blood stasis, and reduce inflammation and relieve pain. The powder uses dragon bone and red ochre as the principal ingredients, notoginseng as the assistant ingredient, and rhubarb as the adjuvant ingredient to make an external powder preparation, which is used to quickly relieve pain, astringe and promote tissue regeneration, and inhibit bacteria and fight infection. When the ointment and powder are used together, the powder is first evenly sprinkled on the surface of the wound, and then the ointment is evenly applied over the powder.

2. A method for preparing a traditional Chinese medicine ointment for treating burns and scalds and difficult-to-heal wounds, characterized in that, Includes the following steps: Rhubarb, Sanguisorba officinalis, Rehmannia glutinosa, and Lithospermum erythrorhizon are soaked in edible sesame oil and then heated to extract the oil. The oil is first heated to 110-120℃ and maintained for 30-60 minutes, then heated to 125-135℃ and simmered until the surface of the herbs is dark brown and the inside is charred but not carbonized. The dregs are filtered out to obtain the medicinal oil. The medicinal oil is heated to 85-95℃, beeswax is added and stirred until melted, then fine powder of calcined gypsum, frankincense, and coarse powder of myrrh are added and stirred evenly. The temperature is then lowered to 55-65℃ and saffron is added. The temperature is maintained and the mixture is soaked for 2-4 hours. The saffron dregs are filtered out. The paste is then cooled to 45-50℃, fine powder of borneol is added and stirred quickly until completely dispersed. After cooling and standing, it is sterilized and packaged.

3. The traditional Chinese medicine combination drug according to claim 1, characterized in that, The weight parts of each component in the herbal ointment are as follows: rhubarb 5-15 parts, Sanguisorba officinalis 5-15 parts, Rehmannia glutinosa 10-25 parts, Lithospermum erythrorhizon 8-20 parts, saffron 1-10 parts, frankincense 5-15 parts, myrrh 5-15 parts, beeswax 10-25 parts, and edible sesame oil 80-160 parts.

4. The traditional Chinese medicine combination drug according to claim 1, characterized in that, The herbal ointment also includes 15-35 parts of calcined gypsum and 1-5 parts of borneol as adjuvants.

5. The traditional Chinese medicine combination drug according to claim 1, characterized in that, The weight parts of each component in the Chinese herbal powder are as follows: 20-40 parts of dragon bone, 20-40 parts of red ochre, 10-25 parts of Panax notoginseng, and 10-30 parts of rhubarb.

6. The traditional Chinese medicine combination drug according to claim 1, characterized in that, When the herbal ointment and the herbal powder are used together, the dressing should be changed 1 to 2 times a day, depending on the depth of the wound and the amount of exudation, until the wound is completely healed.

7. The traditional Chinese medicine combination drug according to claim 1, characterized in that, In the preparation of the herbal ointment, during the ointment collection stage, the ointment is cooled to 55-65°C and then saffron is added. The temperature is maintained and the ointment is soaked for 2-4 hours, after which the saffron residue is filtered out.

8. The traditional Chinese medicine combination drug according to claim 7, characterized in that, In the preparation of the herbal ointment, the ointment is cooled to 45-50°C and then fine borneol powder is added, followed by rapid stirring until completely dispersed.

9. The traditional Chinese medicine combination drug according to claim 1, characterized in that, In the preparation of the herbal ointment, rhubarb, sanguisorba officinalis, rehmannia glutinosa, and gromwell are soaked in edible sesame oil for 12 to 24 hours. The oil is then heated to 110 to 120°C and maintained for 30 to 60 minutes. The temperature is then increased to 125 to 135°C and simmered until the surface of the herbs turns dark brown and the inside is charred but not carbonized. Heating is then stopped.

10. The traditional Chinese medicine combination drug according to claim 1, characterized in that, In the preparation of the traditional Chinese medicine powder, the dragon bone and red ochre are crushed and calcined in a high-temperature furnace. After cooling, they are coarsely pulverized and passed through a 60-mesh sieve. Then, they are mixed with Panax notoginseng and rhubarb according to the prescription ratio and finely pulverized and passed through a 150-mesh sieve to obtain the mixed powder.