A medicine for treating chronic constipation of yin deficiency and dry intestine type and a preparation method thereof

Abstract

The application discloses a medicine for treating chronic constipation of yin deficiency and intestinal dryness, and the medicine is prepared from a first traditional Chinese medicine composition, a second traditional Chinese medicine composition and a third traditional Chinese medicine composition according to the disease manifestation and treatment stages. The first traditional Chinese medicine composition and the second traditional Chinese medicine composition are used in combination for treating constipation of yin deficiency and intestinal dryness accompanied by intestinal latent heat. After the second traditional Chinese medicine composition is used for treatment, the latent heat in the intestines is removed, and then the first traditional Chinese medicine composition is used. The first traditional Chinese medicine composition and the third traditional Chinese medicine composition are used in combination for treating different stages of pathogenesis. The first traditional Chinese medicine composition is mainly used for nourishing yin, moisturizing the intestines, promoting defecation, promoting qi and removing stagnation, treating deficiency and excess simultaneously, moistening dry intestines, removing stagnation and restoring the transmission of the intestines. The third traditional Chinese medicine composition is used later, and the medicine is used for nourishing yin and tonifying deficiency, moisturizing the intestines, tonifying qi and invigorating the body, and is used for tonifying and nourishing, and is used for best recovery of yin, liquid filling, moistening of the intestines and restoration of the transmission of the intestines, so that the chronic constipation is radically treated.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine technology, and in particular to a medicine for treating chronic constipation of the yin deficiency and intestinal dryness type and its preparation method. Background Technology

[0002] Constipation due to yin deficiency and intestinal dryness is the most common and specific syndrome type of chronic constipation, characterized by high incidence and stubbornness. Common symptoms include: reduced bowel movement frequency, once every few days or even once every ten days or more; dry, hard, and difficult-to-pass stools; accompanied by abdominal distension and frequent flatulence; patients often use laxatives or enemas to maintain bowel movements; after several days of regular bowel movements, there is no abdominal distension or pain, appetite is normal, but no urge to defecate; until the next bowel movement, the symptoms return to normal. This disease has a high incidence, stubbornness, and a long history, often lasting several years or more. If not treated correctly, patients may even suffer from the disease for life.

[0003] The pathogenesis of this disease is due to deficiency of Yin and depletion of body fluids, resulting in intestinal dryness and impaired intestinal motility. This is clearly explained in many traditional Chinese medicine texts. Zhongjing's *Treatise on Cold Damage*, in the Yangming disease chapter, article 247, states, "The pulse of the 'Di Yang' is floating and hesitant; floating indicates strong stomach Qi, hesitant indicates frequent urination; when floating and hesitant combine, the stool becomes hard, indicating spleen deficiency; Ma Ren Wan (Hemp Seed Pill) is the main treatment." The *Synopsis of Prescriptions of the Golden Chamber*, in the chapter 21 on postpartum diseases and pulse diagnosis, points out, "...loss of body fluids, dry stomach, hence difficult defecation." The first article, with its floating and hesitant pulse, refers to Yangming stomach heat and Taiyin spleen (Yin) deficiency, a combined Yangming and Taiyin disease leading to constipation, a condition of both deficiency and excess, similar to but not identical to this disease. The second article, "loss of body fluids, dry stomach," refers to postpartum blood loss and Yin deficiency, failing to moisten the stomach (intestines) and causing difficult defecation, purely Yin deficiency, a condition of deficiency leading to excess, consistent with the nature of this disease. In his book *Wenbing Tiaobian*, Wu Jutong, a renowned expert on febrile diseases in later generations, described the pathogenesis of constipation due to yin deficiency and intestinal dryness as "a boat stopped without water." This name is the most vivid, apt, and accurate summary of the etiology and pathogenesis of constipation due to yin deficiency and intestinal dryness. The above-mentioned literature provides an important theoretical basis for the etiology and pathogenesis of chronic constipation due to yin deficiency and intestinal dryness.

[0004] Since the etiology of this disease (syndrome) is clear, according to the principles of traditional Chinese medicine—treating the root cause and analyzing the underlying cause—the correct treatment should be nourishing Yin and replenishing fluids, moistening the intestines and promoting bowel movements. However, current market research shows that while there are many medications for constipation, they all rely on purgation. For example, products like Xiangdanqing, Tongbian capsules, Biannaitong tea, and Changqing tea all function as laxatives. When used for this condition, they cause diarrhea upon administration, but constipation returns upon discontinuation. This type of constipation is stubborn; relying solely on laxatives not only fails to address the root cause but also, with prolonged use, can cause intestinal atrophy and deplete Qi and Yin, leading to further Yin deficiency and worsening constipation. Therefore, currently available over-the-counter medications are unsuitable for treating this type of constipation.

[0005] Referring to medical classics, classical prescriptions for chronic constipation, such as Maren Pill, Wuren Pill, Ziyin Decoction, and Zengye Chengqi Decoction, are all commonly used in clinical treatment of chronic constipation. However, for constipation of this specific syndrome type, rigidly copying these prescriptions without adaptation will not be quite appropriate. Several of these prescriptions are analyzed as follows:

[0006] The Maren Pill is formulated with hemp seed as the monarch drug, supplemented with apricot kernel and white peony root, and combined with Xiao Chengqi Tang. It nourishes yin and purges heat simultaneously, and is suitable for conditions of Yangming stomach heat combined with Taiyin spleen (yin) deficiency. If used to treat the present condition, it will have the drawback of damaging yin due to prolonged purgation, so it is obviously not suitable for the present condition.

[0007] The Ziyue Chengqi Tang is formulated by combining Ziyue Decoction and Tiaowei Chengqi Tang. Although its yin-nourishing effect is far superior to that of Maren Pill, the formula contains natrii sulfas and rheum, which still belongs to the category of simultaneous yin nourishing and heat purging, and is suitable for cases of constipation seen in the late stage of new febrile diseases, where pathogenic heat has damaged yin, yin fluid is already deficient, and pathogenic heat has not yet been completely eliminated. Once the stool is unobstructed and fluid is restored, the disease will heal on its own. However, the present syndrome of yin deficiency with fluid exhaustion is a chronic and intractable disease. With a long medical history, the pathogenesis is deeply rooted, and the disease cannot be cured simply by unobstructing the stool. Only when the body fluid in the intestines is restored and the intestinal conduction function returns to normal can a cure be expected. To achieve this goal, a short course of treatment is not sufficient. Therefore, if this prescription is used for long-course treatment of the present condition, it still has the drawback of consuming qi and damaging yin due to prolonged purgation. Contents of the Invention

[0008] Therefore, based on the above background, the present invention is developed on the basis of traditional prescriptions, through years of practice and continuous exploration and innovation. The invented drug has the effects of nourishing yin and promoting fluid production, moistening intestines and relaxing bowels, which can enrich yin fluid, moisten the intestines, promote the recovery of normal intestinal conduction function, be suitable for long-course treatment of chronic constipation of yin deficiency and intestinal dryness type, and can achieve radical cure for chronic and intractable constipation of yin deficiency and intestinal dryness type.

[0009] The technical solution provided by the present invention is as follows:

[0010] A drug for treating chronic constipation of yin deficiency and intestinal dryness type, which at least comprises one of a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition:

[0011] In parts by weight, the first traditional Chinese medicine composition is composed of the following raw materials:

[0012] 24-30 parts of dried rehmannia root, 24-30 parts of figwort root, 24-30 parts of dwarf lilyturf tuber, 24-30 parts of hemp seed, 15-20 parts of arborvitae seed, 10-12 parts of peach kernel, 10-15 parts of pseudostellaria root, 10-15 parts of common yam rhizome, 10-12 parts of finger citron, 10-12 parts of angelica root, 10-12 parts of raw fleeceflower root, 10-12 parts of medicated leaven, 3-5 parts of licorice root, 24-30 parts of trichosanthes seed, 12-15 parts of apricot kernel, 12-15 parts of radish seed, 12-15 parts of perilla seed, 10-12 parts of immature bitter orange, 5-8 parts of longstamen onion bulb, 2-3 parts of prepared rhubarb;

[0013] In parts by weight, the second traditional Chinese medicine composition is composed of the following raw materials:

[0014] 24-30 parts of Rehmannia glutinosa, 24-30 parts of Scrophularia ningpoensis, 24-30 parts of Ophiopogon japonicus, 24-30 parts of Cannabis sativa, 15-20 parts of Platycladus orientalis, 10-12 parts of Prunus persica, 10-15 parts of Pseudostellaria heterophylla, 10-15 parts of Dioscorea opposita, 10-12 parts of Citrus medica, 10-12 parts of Angelica sinensis, 10-12 parts of Polygonum multiflorum, 10-12 parts of Massa fermentata, 3-5 parts of Glycyrrhiza uralensis, 24-30 parts of Trichosanthes kirilowii, 12-15 parts of Prunus armeniaca, 12-15 parts of Raphanus sativus, 12-15 parts of Perilla frutescens, 10-12 parts of Citrus aurantium, 5-8 parts of Allium macrostemon, 2-3 parts of Rheum palmatum (processed), 10-15 parts of Phellodendron chinense, 12-15 parts of Lonicera japonica, and 12-15 parts of Taraxacum mongolicum.

[0015] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0016] 24-30 parts of Rehmannia glutinosa, 24-30 parts of Scrophularia ningpoensis, 24-30 parts of Ophiopogon japonicus, 24-30 parts of Cannabis sativa, 15-20 parts of Platycladus orientalis, 5-8 parts of Prunus persica, 12-15 parts of Codonopsis pilosula, 12-15 parts of Dioscorea opposita, 10-12 parts of Citrus medica, 10-12 parts of Angelica sinensis, 10-12 parts of Polygonum multiflorum, 10-12 parts of Medicated leaven, and 4-5 parts of Glycyrrhiza uralensis.

[0017] Preferably, the first traditional Chinese medicine composition comprises, by weight, the following raw materials:

[0018] 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 10 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, 4 parts Glycyrrhiza uralensis, 24 parts Trichosanthes kirilowii, 15 parts Prunus armeniaca, 15 parts Raphanus sativus, 15 parts Perilla frutescens, 10 parts Citrus aurantium, 5 parts Allium macrostemon, 2 parts Rheum palmatum (processed).

[0019] Preferably, the first traditional Chinese medicine composition comprises, by weight, the following raw materials:

[0020] 28 parts Rehmannia glutinosa, 26 parts Scrophularia ningpoensis, 25 parts Ophiopogon japonicus, 30 parts Cannabis sativa, 18 parts Platycladus orientalis, 11 parts Prunus persica, 12 parts Codonopsis pilosula, 13 parts Dioscorea opposita, 11 parts Citrus medica, 11 parts Angelica sinensis, 12 parts Polygonum multiflorum, 12 parts Massa fermentata, 5 parts Glycyrrhiza uralensis, 28 parts Trichosanthes kirilowii, 14 parts Prunus armeniaca, 13 parts Raphanus sativus, 14 parts Perilla frutescens, 11 parts Citrus aurantium, 8 parts Allium macrostemon, 3 parts Rheum palmatum (processed).

[0021] Preferably, the second traditional Chinese medicine composition comprises, by weight, the following raw materials:

[0022] 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 10 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, 4 parts Glycyrrhiza uralensis, 24 parts Trichosanthes kirilowii, 15 parts Prunus armeniaca, 15 parts Raphanus sativus, 15 parts Perilla frutescens, 10 parts Citrus aurantium, 5 parts Allium macrostemon, 2 parts Rheum palmatum (processed), 12 parts Phellodendron chinense, 15 parts Lonicera japonica, 12 parts Taraxacum mongolicum.

[0023] Preferably, the third traditional Chinese medicine composition comprises, by weight, the following raw materials:

[0024] 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 5 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, and 4 parts Glycyrrhiza uralensis.

[0025] Preferably, the third traditional Chinese medicine composition comprises, by weight, the following raw materials:

[0026] 30 parts Rehmannia glutinosa, 28 parts Scrophularia ningpoensis, 26 parts Ophiopogon japonicus, 25 parts Cannabis sativa, 18 parts Platycladus orientalis, 7 parts Prunus persica, 13 parts Codonopsis pilosula, 15 parts Dioscorea opposita, 11 parts Citrus medica, 12 parts Angelica sinensis, 12 parts Polygonum multiflorum, 12 parts Massa fermentata, and 5 parts Glycyrrhiza uralensis.

[0027] Furthermore, the first, second, and third traditional Chinese medicine compositions can all be formulated into oral dosage forms by adding medically acceptable excipients.

[0028] Preferably, the preparation of the first or second traditional Chinese medicine composition includes the following steps:

[0029] Add 2-3 times its own weight of water to the raw materials and soak for 30-50 minutes. Then bring to a boil over high heat and simmer over low heat for 30-50 minutes. Collect the liquid. Add water to the dregs again and continue to simmer for 20-30 minutes. Collect the liquid. Combine the two liquids to obtain the final product.

[0030] Preferably, the preparation of the third traditional Chinese medicine composition includes the following steps: drying and pulverizing the raw materials, refining them with honey to form pills, each pill weighing 35-45g.

[0031] The pharmacological properties of the drug of the present invention are as follows:

[0032] In the first traditional Chinese medicine composition of the present invention:

[0033] The formula uses Scrophularia, Rehmannia, and Ophiopogon as the principal herbs: Scrophularia, sweet, bitter, and cold in nature, black in color and moist in texture, enters the lung, stomach, and kidney meridians, and its main functions are to nourish yin and generate fluids, clear heat and detoxify; Rehmannia, sweet, bitter, and cold in nature, enters the heart, liver, and kidney meridians, and its main functions are to clear heat and cool blood, nourish yin and generate fluids; Ophiopogon, sweet, slightly bitter, and slightly cold in nature, enters the heart, lung, and kidney meridians, and its main functions are to nourish yin and clear heat, moisten the lungs and stop cough. The three herbs together are the main herbs in the formula to treat the root cause of yin deficiency in this condition, so that yin fluids can be restored, the intestines can be moistened, and the intestinal motility can be restored to normal.

[0034] The formula uses cypress seed, apricot kernel, peach kernel, hemp seed, trichosanthes seed, perilla seed, radish seed, angelica, and fleeceflower root as assistant herbs: Angelica is sweet, bitter, and warm in nature, enters the heart, liver, and spleen meridians, and functions to nourish blood, regulate menstruation, and moisten the intestines to relieve constipation; raw fleeceflower root is bitter, astringent, and slightly warm in nature, enters the liver and kidney meridians, and functions to relieve constipation and detoxify sores; cypress seed is sweet, pungent, and neutral in nature, enters the heart, liver, and kidney meridians, and functions to nourish the heart, calm the mind, and moisten the intestines to relieve constipation; apricot kernel is sweet and neutral in nature, enters the lung and large intestine meridians, and functions to stop coughing and asthma, and moisten the intestines to relieve constipation; peach kernel is bitter, sweet, and neutral in nature, enters the heart, liver, and large intestine meridians, and functions to break up blood stasis, remove blood stasis, and moisten the intestines to relieve constipation. Adding hemp seed, sweet and neutral in nature, entering the spleen, stomach, and large intestine meridians, its functions are to moisten dryness, lubricate the intestines, nourish and replenish deficiency; trichosanthes seed, sweet and cold in nature, entering the lung, stomach, and large intestine meridians, its functions are to moisten dryness, eliminate phlegm, lubricate the intestines and promote bowel movement; perilla seed, pungent and warm in nature, entering the lung meridian, its functions are to eliminate phlegm, relieve asthma, lower qi and widen the intestines; radish seed, pungent, sweet, and neutral in nature, entering the spleen, stomach, and lung meridians, its functions are to regulate qi, promote digestion, lower qi and eliminate phlegm. All these herbs are rich in oils, working together to moisten dryness, lubricate the intestines, and liquefy dry stools. Apricot kernel, trichosanthes seed, perilla seed, and radish seed, while moistening the intestines, also have a descending effect, working synergistically with the main herbs to promote bowel movement; angelica and he shou wu, used together, assist the principal herbs in moistening the intestines and promoting bowel movement; angelica combined with peach kernel can invigorate blood and remove blood stasis, improve intestinal wall blood circulation, and benefit intestinal function repair; he shou wu also has detoxifying properties.

[0035] The formula uses Buddha's Hand, Fructus Aurantii Immaturus, Radix Allii Macrocephalae, Radix Codonopsis, Rhizoma Dioscoreae, Radix Rhei, and Radix Massa Fermentata as adjuvant herbs. When fecal matter accumulates and qi is obstructed, the accumulation worsens, leading to more severe bloating. Buddha's Hand is pungent, slightly bitter, and warm in nature, entering the spleen, stomach, and liver meridians. Its functions include soothing the liver and relieving depression, regulating qi and harmonizing the stomach, and drying dampness and resolving phlegm. Fructus Aurantii Immaturus is bitter and slightly cold in nature, entering the spleen and stomach meridians. Its functions include breaking up qi stagnation and resolving phlegm, and it is good at descending qi. Radix Allii Macrocephalae is pungent, bitter, and warm in nature, entering the lung, stomach, and large intestine meridians. Its function is to descend qi and disperse stagnation. These three adjuvant herbs regulate qi, relieve bloating, and promote the flow of qi and the elimination of accumulated waste, thus facilitating the expulsion of dry feces. Radix Codonopsis is sweet, slightly bitter, and warm in nature, entering the lung and spleen meridians. Its function is to tonify the spleen and replenish qi. Radix Dioscoreae is sweet and neutral in nature, entering the lung, spleen, and kidney meridians. Its function is to tonify the spleen and stomach, and benefit the lung and kidney. These two herbs are used to tonify spleen qi and benefit spleen yin. Prolonged illness inevitably leads to qi deficiency, which weakens intestinal function and transmission. Strengthening the body's vital energy is beneficial for restoring intestinal function. Rhubarb, with its bitter and cold properties, enters the heart, stomach, and large intestine meridians, effectively purging stagnation, clearing heat, cooling the blood, removing blood stasis, and unblocking the meridians. It is used in small amounts in this formula to stimulate intestinal peristalsis and promote intestinal function. Medicated leaven, with its sweet, pungent, and warm properties, enters the spleen and stomach meridians, functioning to aid digestion and harmonize the stomach. When used in this formula, care should be taken to avoid the drawbacks of the oily and greasy nature of other herbs causing stagnation in the spleen; it also serves as an adjuvant.

[0036] Licorice is used as the guiding herb, its sweet and neutral properties harmonizing the other herbs. The entire formula utilizes the rich oils of five kinds of nuts to moisten dryness and lubricate the intestines, quickly expelling dry stool. It is further supplemented with qi-regulating herbs to relieve bloating, and together with other herbs, it nourishes yin, moistens the intestines, and promotes bowel movements. This formula addresses both the root cause and the symptoms, treating both deficiency and excess, focusing on treating the underlying cause. The first herbal combination is carefully selected and rationally combined, adhering to the principle of treating the root cause of disease, thus achieving good efficacy.

[0037] The second traditional Chinese medicine composition of this invention is based on the first traditional Chinese medicine composition, with the addition of Phellodendron bark, honeysuckle, and dandelion. Phellodendron bark is bitter and cold, entering the kidney and bladder meridians, and functions to clear heat and dry dampness, purge fire and detoxify; honeysuckle is sweet and cold, and functions to clear heat and detoxify, cool and disperse wind-heat; dandelion is bitter, sweet, and cold, entering the liver and stomach meridians, and functions to clear heat and detoxify, promote diuresis and dissipate nodules. These three herbs, when combined with the first traditional Chinese medicine composition, not only nourish yin and replenish fluids, but also moisten the intestines and promote bowel movements, while simultaneously clearing heat, purging fire, and detoxifying. It is suitable for treating constipation due to yin deficiency and intestinal dryness, accompanied by latent damp-heat in the intestines. It is a formula that nourishes yin and moistens the intestines, clears heat and detoxifies simultaneously.

[0038] The first traditional Chinese medicine composition of the present invention can be used in combination with the second traditional Chinese medicine composition. Specifically, for constipation of the yin deficiency and intestinal dryness type with latent damp heat in the intestine, the second traditional Chinese medicine composition can be used first for treatment. After the patient’s symptoms such as abdominal pain and saliva in the stool disappear, that is, the latent heat in the intestine has been eliminated, the first traditional Chinese medicine composition can be used to continue treatment.

[0039] The third composition of this invention is used for patients who have undergone treatment with the first composition, after which constipation has subsided and bowel movements have become normal, but the intestinal fluid has not yet fully recovered. At this stage, the treatment focuses on nourishing yin and replenishing fluids to ensure sufficient yin fluids, moisten the intestines, and promote the restoration of normal intestinal motility. Therefore, Rehmannia glutinosa, Scrophularia ningpoensis, and Ophiopogon japonicus are used as the main herbs to further nourish yin and replenish fluids, thus restoring yin fluids and moistening the intestines. Hemp seed and Platycladus orientalis seed, which also have nourishing effects, assist the main herbs in replenishing fluids and moistening the intestines. Peach kernel combined with Angelica sinensis, while nourishing blood and moistening the intestines, utilizes its blood-activating effect to improve blood circulation in the intestinal wall, which helps restore intestinal function. Therefore, hemp seed, Platycladus orientalis seed, peach kernel, and Angelica sinensis are used as the assistant herbs. Codonopsis pilosula, Dioscorea opposita, Citrus medica, and medicated leaven are used as adjuvant herbs to promote intestinal motility. Licorice root is used as the guiding herb, as its sweet and neutral properties harmonize the other herbs.

[0040] The beneficial effects that can be achieved by using this invention are as follows:

[0041] This invention utilizes a first, second, and third traditional Chinese medicine composition in combination, based on the symptoms and treatment stages. The first and second compositions are used in combination for constipation due to yin deficiency and intestinal dryness, accompanied by latent intestinal heat. Treatment begins with the second composition; once symptoms such as abdominal pain and salivary discharge disappear (indicating the latent intestinal heat has been eliminated), the first composition is then used to continue treatment. The first and third compositions are used in combination to address the changes in the pathogenic factors and the body's resistance at different stages of treatment. The first composition is used first to nourish yin and replenish fluids... The primary treatment focuses on lubricating the intestines and relieving constipation, supplemented by regulating qi and eliminating stagnation. It addresses both deficiency and excess, tackling both the root cause and the symptoms, restoring yin fluids, moistening dry intestines, clearing stagnation, and restoring normal bowel function. The third herbal composition is used after the first composition. At this stage, the condition improves, yin fluids gradually recover, the intestines become moist, and bowel movements return to normal. This medicine aims to nourish yin and replenish deficiency, nourish yin and replenish fluids, invigorate qi and strengthen the spleen, with an emphasis on nourishing and replenishing deficiency, striving to achieve optimal restoration of yin fluids, ensuring sufficient fluids, moistening the intestines, and restoring normal bowel function. This results in a radical cure for chronic and intractable constipation of the yin deficiency and intestinal dryness type. Furthermore, this invention is suitable for long-term treatment and has no side effects. Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0043] Example 1: A medicine for treating chronic constipation of the Yin deficiency and intestinal dryness type, which is composed of a first traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0044] in:

[0045] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0046] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed).

[0047] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0048] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 5g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis.

[0049] Example 2: A medicine for treating chronic constipation of the Yin deficiency and intestinal dryness type, which is composed of a first traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0050] in:

[0051] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0052] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed).

[0053] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0054] 30g Rehmannia glutinosa, 28g Scrophularia ningpoensis, 26g Ophiopogon japonicus, 25g Cannabis sativa, 18g Platycladus orientalis, 7g Prunus persica, 13g Codonopsis pilosula, 15g Dioscorea opposita, 11g Citrus medica, 12g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis.

[0055] Example 3: A medicine for treating chronic constipation of the Yin deficiency and intestinal dryness type, which is composed of a first traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0056] in:

[0057] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0058] 28g Rehmannia glutinosa, 26g Scrophularia ningpoensis, 25g Ophiopogon japonicus, 30g Cannabis sativa, 18g Platycladus orientalis, 11g Prunus persica, 12g Codonopsis pilosula, 13g Dioscorea opposita, 11g Citrus medica, 11g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis, 28g Trichosanthes kirilowii, 14g Prunus armeniaca, 13g Raphanus sativus, 14g Perilla frutescens, 11g Citrus aurantium, 8g Allium macrostemon, 3g Rheum palmatum (processed).

[0059] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0060] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 5g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis.

[0061] Example 4: A medicine for treating chronic constipation of the Yin deficiency and intestinal dryness type, which is composed of a first traditional Chinese medicine composition and a third traditional Chinese medicine composition;

[0062] in:

[0063] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0064] 28g Rehmannia glutinosa, 26g Scrophularia ningpoensis, 25g Ophiopogon japonicus, 30g Cannabis sativa, 18g Platycladus orientalis, 11g Prunus persica, 12g Codonopsis pilosula, 13g Dioscorea opposita, 11g Citrus medica, 11g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis, 28g Trichosanthes kirilowii, 14g Prunus armeniaca, 13g Raphanus sativus, 14g Perilla frutescens, 11g Citrus aurantium, 8g Allium macrostemon, 3g Rheum palmatum (processed).

[0065] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0066] 30g Rehmannia glutinosa, 28g Scrophularia ningpoensis, 26g Ophiopogon japonicus, 25g Cannabis sativa, 18g Platycladus orientalis, 7g Prunus persica, 13g Codonopsis pilosula, 15g Dioscorea opposita, 11g Citrus medica, 12g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis.

[0067] Example 5: A medicine for treating chronic constipation due to yin deficiency and intestinal dryness, comprising a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition:

[0068] in:

[0069] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0070] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed).

[0071] By weight, the second traditional Chinese medicine composition consists of the following raw materials:

[0072] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed), 12g Phellodendron chinense, 15g Lonicera japonica, 12g Taraxacum mongolicum.

[0073] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0074] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 5g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis.

[0075] Example 6: A medicine for treating chronic constipation due to yin deficiency and intestinal dryness, comprising a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition:

[0076] in:

[0077] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0078] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed).

[0079] By weight, the second traditional Chinese medicine composition consists of the following raw materials:

[0080] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed), 12g Phellodendron chinense, 15g Lonicera japonica, 12g Taraxacum mongolicum.

[0081] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0082] 30g Rehmannia glutinosa, 28g Scrophularia ningpoensis, 26g Ophiopogon japonicus, 25g Cannabis sativa, 18g Platycladus orientalis, 7g Prunus persica, 13g Codonopsis pilosula, 15g Dioscorea opposita, 11g Citrus medica, 12g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis.

[0083] Example 7: A medicine for treating chronic constipation due to yin deficiency and intestinal dryness, comprising a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition:

[0084] in:

[0085] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0086] 28g Rehmannia glutinosa, 26g Scrophularia ningpoensis, 25g Ophiopogon japonicus, 30g Cannabis sativa, 18g Platycladus orientalis, 11g Prunus persica, 12g Codonopsis pilosula, 13g Dioscorea opposita, 11g Citrus medica, 11g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis, 28g Trichosanthes kirilowii, 14g Prunus armeniaca, 13g Raphanus sativus, 14g Perilla frutescens, 11g Citrus aurantium, 8g Allium macrostemon, 3g Rheum palmatum (processed).

[0087] By weight, the second traditional Chinese medicine composition consists of the following raw materials:

[0088] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed), 12g Phellodendron chinense, 15g Lonicera japonica, 12g Taraxacum mongolicum.

[0089] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0090] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 5g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis.

[0091] Example 8: A medicine for treating chronic constipation due to yin deficiency and intestinal dryness, comprising a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition:

[0092] in:

[0093] By weight, the first traditional Chinese medicine composition consists of the following raw materials:

[0094] 28g Rehmannia glutinosa, 26g Scrophularia ningpoensis, 25g Ophiopogon japonicus, 30g Cannabis sativa, 18g Platycladus orientalis, 11g Prunus persica, 12g Codonopsis pilosula, 13g Dioscorea opposita, 11g Citrus medica, 11g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis, 28g Trichosanthes kirilowii, 14g Prunus armeniaca, 13g Raphanus sativus, 14g Perilla frutescens, 11g Citrus aurantium, 8g Allium macrostemon, 3g Rheum palmatum (processed).

[0095] By weight, the second traditional Chinese medicine composition consists of the following raw materials:

[0096] 24g Rehmannia glutinosa, 24g Scrophularia ningpoensis, 24g Ophiopogon japonicus, 24g Cannabis sativa, 15g Platycladus orientalis, 10g Prunus persica, 12g Codonopsis pilosula, 12g Dioscorea opposita, 10g Citrus medica, 10g Angelica sinensis, 10g Polygonum multiflorum, 10g Massa fermentata, 4g Glycyrrhiza uralensis, 24g Trichosanthes kirilowii, 15g Prunus armeniaca, 15g Raphanus sativus, 15g Perilla frutescens, 10g Citrus aurantium, 5g Allium macrostemon, 2g Rheum palmatum (processed), 12g Phellodendron chinense, 15g Lonicera japonica, 12g Taraxacum mongolicum.

[0097] By weight, the third traditional Chinese medicine composition comprises the following raw materials:

[0098] 30g Rehmannia glutinosa, 28g Scrophularia ningpoensis, 26g Ophiopogon japonicus, 25g Cannabis sativa, 18g Platycladus orientalis, 7g Prunus persica, 13g Codonopsis pilosula, 15g Dioscorea opposita, 11g Citrus medica, 12g Angelica sinensis, 12g Polygonum multiflorum, 12g Massa fermentata, 5g Glycyrrhiza uralensis.

[0099] In the above embodiment, the amount of raw materials used in the first pharmaceutical composition, the second traditional Chinese medicine composition, and the third traditional Chinese medicine composition are all the same as the dosage of one dose of medicine.

[0100] For example, when treating patients, a dose of either the first or second traditional Chinese medicine composition can usually be taken daily, for example, by decocting it in water.

[0101] In the above embodiments, the preparation of the decoction of the first, second, or third traditional Chinese medicine composition is as follows:

[0102] Add 600-750ml of water to the raw materials and soak for 30-40 minutes. Then bring to a boil over high heat and simmer over low heat for 40-50 minutes. Take 250ml of the decoction. Add 350-400ml of water to the dregs again and continue to simmer for 20-30 minutes. Take 200ml of the decoction. Combine the two decoctions to obtain the final product.

[0103] Take the decoction on an empty stomach, one dose per day, divided into 2 to 3 doses.

[0104] The third traditional Chinese medicine composition can also be prepared into honey pills, the preparation of which is shown below:

[0105] The raw materials are dried, pulverized, and mixed with honey to form pills, each weighing 35g-45g. The pills are taken on an empty stomach, three times a day, one pill each time.

[0106] The first traditional Chinese medicine composition of the present invention is a causal treatment for chronic constipation of the Yin deficiency and intestinal dryness type. It has the effects of nourishing Yin and replenishing fluids, moistening the intestines and promoting bowel movement. It is suitable for patients whose initial symptoms are reduced bowel movement frequency, once every few days or even more than ten days, with dry and hard stools like chess pieces or sheep droppings, difficult to pass, accompanied by abdominal distension and frequent flatulence. If a laxative is used to defecate, there is no urge to defecate for several days, no abdominal distension or pain, and normal appetite. When the next bowel movement comes, the symptoms return to the same state, and the cycle repeats itself. The diagnosis is constipation of the Yin deficiency and intestinal dryness type.

[0107] The second traditional Chinese medicine composition of the present invention is composed of Phellodendron bark, honeysuckle, and dandelion on the basis of the first traditional Chinese medicine composition. It has the effects of nourishing yin and replenishing fluids, moistening the intestines and relieving constipation, as well as purging fire, clearing heat and detoxifying. Therefore, it is suitable for constipation of yin deficiency and intestinal dryness type, with latent damp heat in the intestines, symptoms such as lower abdominal pain before defecation, pain and urge to defecate, mucus in the stool, or accompanied by bitter taste in the mouth and yellow urine.

[0108] The third herbal composition of the present invention is suitable for patients who have been treated with the first herbal composition, after which the constipation has subsided but the intestinal fluid has not yet fully recovered. At this time, the focus is on nourishing yin and replenishing fluids, so that body fluids are generated internally, the intestines are moistened, and the intestinal conduction function is restored. This formula can be prepared as a decoction or as pills, depending on the patient's recovery.

[0109] Therefore, in the above Examples 1 to 4, when treating patients, the first Chinese medicine composition was taken first. After the constipation was relieved and bowel movements became normal, the third Chinese medicine composition was taken until the patient recovered.

[0110] Examples 5 to 8 above are applicable to the treatment of patients with constipation due to yin deficiency and intestinal dryness, accompanied by latent damp-heat in the intestines. During treatment, after the patient's abdominal pain and saliva in the stool disappear, indicating that the latent heat in the intestines has been eliminated, the first Chinese medicine composition is used to continue the treatment. That is, the first Chinese medicine composition is taken first, followed by the third Chinese medicine composition until the patient is cured.

[0111] Precautions regarding the use of this drug in the treatment of chronic constipation:

[0112] Because this condition is stubborn, has a long medical history, and is slow to respond to treatment, the course of treatment often needs to be calculated in months. Except for a few young patients with a short course of illness and strong recovery ability who may only require one month of treatment, most patients require two or three courses of treatment, and a few even more than three. The treatment goal is to achieve optimal recovery of intestinal function in order to achieve a radical cure and ensure long-term efficacy. The previous course of treatment was one month.

[0113] Based on the inventor's long-term experience in treating patients, the following points should be followed and noted:

[0114] In the initial treatment of this disease, if the stool becomes softer and bowel movements become smoother, this only indicates an improvement in the condition, not a cure. The improvement in symptoms at this time is mainly due to the laxative effect of the medication, rather than a sign of complete restoration of intestinal fluids. If the medication is stopped too early or the medication is changed too quickly, it often leads to a recurrence of the condition.

[0115] When the first, second, and third traditional Chinese medicine compositions are used in combination, specifically when changing the dosage during treatment, the changes should be made sequentially and gradually, and it is not advisable to skip levels too quickly.

[0116] Each change or replacement of the treatment plan should be based on the patient's symptoms of softer stool, smoother bowel movements, and bowel movements once or twice a day, which indicates that intestinal function is gradually returning to normal.

[0117] Each Chinese herbal medicine combination, especially the third one, must be observed for about a week before being withdrawn or discontinued. If the patient shows signs of rebound, such as constipation, reduced frequency of bowel movements, or difficulty in defecation, it means that the intestinal fluid has not reached the recovery target. In this case, the Chinese herbal medicine combination used before withdrawal or discontinuation should be used for continued treatment. Only when the patient shows no signs of rebound can the intestinal fluid be considered to have recovered to the ideal level, and then medication can be discontinued to ensure the radical cure of the disease and its long-term efficacy.

[0118] The second Chinese medicine composition is used for patients with this type of disease who also have intestinal heat. The course of treatment is usually about 10 days. After more than 10 days of medication, most patients will see the disappearance of symptoms such as abdominal pain and drooling in their stool. This means that the latent heat in the intestines has been eliminated, and it is appropriate to switch to the first Chinese medicine composition for continued treatment.

[0119] Example 9: Clinical Data

[0120] Of the 21 patients diagnosed with chronic constipation of the Yin deficiency and intestinal dryness type who came to our clinic, 4 were under 20 years old, 12 were between 20 and 60 years old, and 5 were over 60 years old; 7 had a disease course of less than 3 years, 10 had a disease course of 3 to 8 years, and 4 had a disease course of more than 8 years. None of the patients had concurrent intestinal heat accumulation.

[0121] All patients were treated using Example 1 of the present invention.

[0122] The patient was first treated with the first Chinese herbal combination, a decoction, taken once a day, divided into 2 to 3 doses. Then, the patient was treated with the third Chinese herbal combination, a decoction, taken once a day, divided into 2 to 3 doses. The treatment lasted for 3 months (those who recovered could stop taking the medication earlier).

[0123] Treatment efficacy criteria:

[0124] Recovery: After treatment, bowel movements will occur at least once every 1-2 days, with soft stools and smooth defecation;

[0125] Improvement: If bowel movements do not reach the above-mentioned recovery indicators after treatment, bowel movements occur more than once every 2 days, the stool is not soft, and bowel movements are still difficult to varying degrees.

[0126] Ineffective: During treatment, the condition does not improve significantly, defecation is still difficult, and the stool is dry or hard.

[0127] Treatment results: 7 patients recovered, 9 patients improved, and 5 patients showed no improvement.

[0128] The treatment results are statistically analyzed below, categorized by age group, disease duration, and treatment efficacy:

[0129] ①According to age

[0130] in:

[0131] Patients under 20 years old (4 people): 3 people recovered and 1 person improved;

[0132] Patients aged 20-60 (12 people): 4 recovered, 5 improved, and 3 had no effect;

[0133] Patients over 60 years old (5 people): 3 people improved, and 2 people had no effect.

[0134] ②According to the course of the disease

[0135] in:

[0136] Patients with a disease course of less than 3 years (7 people): 4 people were cured, 1 person improved, and 2 people had no effect;

[0137] Patients aged 3-8 years (10 people): 3 people were cured, 5 people improved, and 2 people had no effect;

[0138] Patients with more than 8 years of illness (4 people): 3 people improved, and 1 person had no effect.

[0139] ③According to the course of treatment

[0140] Seven people have recovered, including:

[0141] One person recovered within one month of treatment, five people recovered within two months of treatment, and one person recovered after more than two months of treatment.

[0142] Nine people improved, including two who improved within two months of treatment and seven who improved after more than two months of treatment.

[0143] All five patients responded to treatment for more than two months without improvement.

[0144] Based on the above clinical treatment findings, it is evident that patient outcomes are closely related to age, disease duration, and treatment duration. For instance, younger patients tend to have stronger recovery capabilities, and shorter disease durations result in less damage to bodily functions. All of these factors should be considered when analyzing prognosis during treatment.

[0145] Example 10: Typical Case

[0146] Case 1: Ms. Wei, 42 years old, visited the clinic on March 12, 2016.

[0147] The patient had a history of constipation for 8 years, having sought treatment at several large hospitals without a complete cure. The condition fluctuated in severity, with bowel movements occurring only once every seven to eight days for the past six months. The stools were hard as chess pieces, difficult to pass, and the patient frequently used enemas or laxatives to maintain bowel movements. This was accompanied by abdominal distension and frequent flatulence. Several days after a bowel movement, the abdominal distension and pain subsided, appetite returned, and the urge to defecate was absent. However, the symptoms returned with the next bowel movement. This cycle repeated itself. Treatment initially involved taking the first herbal composition from Example 1 for half a month. The condition improved slightly, the intervals between bowel movements gradually shortened, and the hardness of the stool lessened somewhat. After 50 days of treatment, bowel movements became once a day, dry but not hard, although some difficulty was felt during defecation. Continued treatment for over half a month finally resulted in softer stools and normal bowel movements. The patient then took the honey pill form of the third herbal composition for three months to consolidate the therapeutic effect. Follow-up visits to date have shown no abnormalities.

[0148] Case 2: Ms. Zeng, 56 years old, visited the clinic on August 16, 2017.

[0149] The patient reported a long history of constipation, having visited numerous hospitals, undergone various examinations, and taken multiple medications. Each medication provided temporary relief, but the constipation would recur upon discontinuation. Tens of thousands of yuan were spent without a cure. Later, a certain imported Japanese medicine was used several times, with slightly better effects, but the symptoms returned within a month of discontinuation. The patient then consulted us. Upon inquiry, the patient's symptoms were almost identical to those of the patient in Case 1. The diagnosis was constipation due to Yin deficiency and intestinal dryness. After two months of treatment with the first herbal decoction from Example 2, bowel movements gradually normalized to once every one to two days. After another month of continued treatment, bowel movements became normal, soft, and occurred once a day. The third herbal decoction was then used for three months to consolidate the treatment. Follow-up visits have shown no recurrence to date.

[0150] Case 3: Ms. Sun, 31 years old, visited the clinic on February 6, 2023.

[0151] The patient experienced a relapse of chronic constipation a year ago due to postpartum imbalance. She had sought treatment at several hospitals in Wuhan and taken various over-the-counter medications, but only achieved temporary relief without a cure. She then came for consultation. Symptoms included bowel movements every 4-5 days, with dry, hard, and difficult-to-pass stools, accompanied by dry mouth, abdominal distension, and frequent, extremely foul-smelling flatulence. She frequently used laxatives to facilitate bowel movements or external enemas to maintain defecation. Several days after bowel movements, the abdominal distension and pain subsided, the urge to defecate disappeared, and her appetite returned to normal. However, the symptoms returned with the next bowel movement. She first took the first herbal combination from Example 1 for one month. Afterward, bowel movements became every 2-3 days, and the hardness of the stool improved, but she still felt incomplete. She continued taking the combination for another month, after which the stool softened, and bowel movements became once a day, with smooth defecation. She then switched to a honey pill formulation of the third herbal combination for consolidation treatment. Follow-up visits showed that she was still undergoing pill treatment and her bowel movements have returned to normal.

[0152] In summary, the present invention provides a treatment for chronic constipation of the Yin deficiency and intestinal dryness type, which has the effects of nourishing Yin and replenishing fluids, moistening the intestines and relieving constipation. When used to treat chronic constipation of the Yin deficiency and intestinal dryness type, it can improve and correct the pathophysiological environment of dryness and lack of moisture in the intestines, restore and rebuild intestinal conduction function, and enable patients to achieve long-term efficacy.

[0153] The present invention and its embodiments have been described above. This description is not restrictive, and the actual implementation is not limited thereto. In conclusion, if those skilled in the art are inspired by this description and, without departing from the spirit of the invention, design similar implementations and embodiments without creative effort, all such designs should fall within the protection scope of the present invention.

Claims

1. A medicine for treating chronic constipation due to yin deficiency and intestinal dryness, characterized in that, It includes at least one of the following: a first traditional Chinese medicine composition, a second traditional Chinese medicine composition, and a third traditional Chinese medicine composition: By weight, the first traditional Chinese medicine composition consists of the following raw materials: 24-30 parts of Rehmannia glutinosa, 24-30 parts of Scrophularia ningpoensis, 24-30 parts of Ophiopogon japonicus, 24-30 parts of Cannabis sativa, 15-20 parts of Platycladus orientalis, 10-12 parts of Prunus persica, 10-15 parts of Pseudostellaria heterophylla, 10-15 parts of Dioscorea opposita, 10-12 parts of Citrus medica, 10-12 parts of Angelica sinensis, 10-12 parts of Polygonum multiflorum, 10-12 parts of Massa fermentata, 3-5 parts of Glycyrrhiza uralensis, 24-30 parts of Trichosanthes kirilowii, 12-15 parts of Prunus armeniaca, 12-15 parts of Raphanus sativus, 12-15 parts of Perilla frutescens, 10-12 parts of Citrus aurantium, 5-8 parts of Allium macrostemon, and 2-3 parts of Rheum palmatum (processed). By weight, the second traditional Chinese medicine composition consists of the following raw materials: 24-30 parts of Rehmannia glutinosa, 24-30 parts of Scrophularia ningpoensis, 24-30 parts of Ophiopogon japonicus, 24-30 parts of Cannabis sativa, 15-20 parts of Platycladus orientalis, 10-12 parts of Prunus persica, 10-15 parts of Pseudostellaria heterophylla, 10-15 parts of Dioscorea opposita, 10-12 parts of Citrus medica, 10-12 parts of Angelica sinensis, 10-12 parts of Polygonum multiflorum, 10-12 parts of Massa fermentata, 3-5 parts of Glycyrrhiza uralensis, 24-30 parts of Trichosanthes kirilowii, 12-15 parts of Prunus armeniaca, 12-15 parts of Raphanus sativus, 12-15 parts of Perilla frutescens, 10-12 parts of Citrus aurantium, 5-8 parts of Allium macrostemon, 2-3 parts of Rheum palmatum (processed), 10-15 parts of Phellodendron chinense, 12-15 parts of Lonicera japonica, and 12-15 parts of Taraxacum mongolicum. By weight, the third traditional Chinese medicine composition comprises the following raw materials: 24-30 parts of Rehmannia glutinosa, 24-30 parts of Scrophularia ningpoensis, 24-30 parts of Ophiopogon japonicus, 24-30 parts of Cannabis sativa, 15-20 parts of Platycladus orientalis, 5-8 parts of Prunus persica, 12-15 parts of Codonopsis pilosula, 12-15 parts of Dioscorea opposita, 10-12 parts of Citrus medica, 10-12 parts of Angelica sinensis, 10-12 parts of Polygonum multiflorum, 10-12 parts of Medicated leaven, and 4-5 parts of Glycyrrhiza uralensis.

2. The medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 1, characterized in that, By weight, the first traditional Chinese medicine composition consists of the following raw materials: 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 10 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, 4 parts Glycyrrhiza uralensis, 24 parts Trichosanthes kirilowii, 15 parts Prunus armeniaca, 15 parts Raphanus sativus, 15 parts Perilla frutescens, 10 parts Citrus aurantium, 5 parts Allium macrostemon, 2 parts Rheum palmatum (processed).

3. The medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 1, characterized in that, 28 parts Rehmannia glutinosa, 26 parts Scrophularia ningpoensis, 25 parts Ophiopogon japonicus, 30 parts Cannabis sativa, 18 parts Platycladus orientalis, 11 parts Prunus persica, 12 parts Codonopsis pilosula, 13 parts Dioscorea opposita, 11 parts Citrus medica, 11 parts Angelica sinensis, 12 parts Polygonum multiflorum, 12 parts Massa fermentata, 5 parts Glycyrrhiza uralensis, 28 parts Trichosanthes kirilowii, 14 parts Prunus armeniaca, 13 parts Raphanus sativus, 14 parts Perilla frutescens, 11 parts Citrus aurantium, 8 parts Allium macrostemon, 3 parts Rheum palmatum (processed).

4. The medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 1, characterized in that, By weight, the second traditional Chinese medicine composition consists of the following raw materials: 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 10 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, 4 parts Glycyrrhiza uralensis, 24 parts Trichosanthes kirilowii, 15 parts Prunus armeniaca, 15 parts Raphanus sativus, 15 parts Perilla frutescens, 10 parts Citrus aurantium, 5 parts Allium macrostemon, 2 parts Rheum palmatum (processed), 12 parts Phellodendron chinense, 15 parts Lonicera japonica, 12 parts Taraxacum mongolicum.

5. The medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 1, characterized in that, By weight, the third traditional Chinese medicine composition comprises the following raw materials: 24 parts Rehmannia glutinosa, 24 parts Scrophularia ningpoensis, 24 parts Ophiopogon japonicus, 24 parts Cannabis sativa, 15 parts Platycladus orientalis, 5 parts Prunus persica, 12 parts Codonopsis pilosula, 12 parts Dioscorea opposita, 10 parts Citrus medica, 10 parts Angelica sinensis, 10 parts Polygonum multiflorum, 10 parts Massa fermentata, and 4 parts Glycyrrhiza uralensis.

6. The medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 1, characterized in that, By weight, the third traditional Chinese medicine composition comprises the following raw materials: 30 parts Rehmannia glutinosa, 28 parts Scrophularia ningpoensis, 26 parts Ophiopogon japonicus, 25 parts Cannabis sativa, 18 parts Platycladus orientalis, 7 parts Prunus persica, 13 parts Codonopsis pilosula, 15 parts Dioscorea opposita, 11 parts Citrus medica, 12 parts Angelica sinensis, 12 parts Polygonum multiflorum, 12 parts Massa fermentata, and 5 parts Glycyrrhiza uralensis.

7. A remedy for chronic constipation of yin deficiency and intestinal dryness type according to any one of claims 1 to 6, characterized in that, The first, second, and third traditional Chinese medicine compositions can all be formulated into oral dosage forms by adding medically acceptable excipients.

8. A medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 7, characterized in that, The preparation of the first or second traditional Chinese medicine composition as a decoction includes the following steps: Add 2-3 times its own weight of water to the raw materials and soak for 30-50 minutes. Bring to a boil over high heat, then simmer over low heat for 30-50 minutes and collect the liquid. Add water to the dregs again and continue to simmer for 20-30 minutes and collect the liquid. Combine the two liquids to obtain the final product.

9. A medicine for treating chronic constipation of yin deficiency and intestinal dryness type according to claim 7, characterized in that, The preparation of the third traditional Chinese medicine composition in the form of pills includes the following steps: The raw materials are dried, pulverized, and made into pills with honey, each weighing 35-45g.