A pharmafood composition for improving obesity of spleen deficiency and dampness obstruction type, a preparation method and application thereof

Abstract

The present application relates to the technical field of medicinal and edible, in particular to a kind of medicinal and edible composition for improving obesity of spleen deficiency and dampness obstruction, preparation method and application.The composition includes 20-40 parts of radix codonopsis, 15-30 parts of dioscorea, 15-30 parts of white kidney bean, 10-20 parts of fried hawthorn, 10-20 parts of malt, 10-20 parts of chicken gizzard, 10-20 parts of jujube seed, 5-15 parts of radix puerariae, 5-15 parts of mace, 5-15 parts of anise, 5-15 parts of red bean, 15-25 parts of fried coix seed, 5-15 parts of agastache, 5-15 parts of polygonatum, 10-20 parts of lotus leaf, 5-15 parts of bergamot, 5-15 parts of dried tangerine or orange peel, 5-15 parts of medlar, 5-15 parts of longan arillus, 5-15 parts of ganoderma lucidum;The composition can restore the original of spleen and stomach transportation by invigorating the spleen and replenishing qi, eliminate internal dampness by aromatic dampness and water, and block the cause of improper diet by food digestion and stagnation, effectively intervene obesity of spleen deficiency and dampness obstruction.

Description

Technical Field

[0001] This invention relates to the field of food and medicine homology technology, and more specifically, to a food and medicine homology composition for improving spleen deficiency and dampness-retention type obesity, its preparation method and application. Background Technology

[0002] Obesity has become a global public health problem. In my country, with improved living conditions and changes in dietary structure, the incidence of obesity continues to rise. Chronic diseases caused by obesity, such as hyperlipidemia, hypertension, diabetes, hyperuricemia, and stroke, have become common, seriously threatening national health. Obesity can be divided into simple obesity and secondary obesity, with the vast majority of obese individuals suffering from simple obesity.

[0003] In the TCM theory system, obesity is closely related to irregular diet and dysfunction of the internal organs. The spleen is responsible for transporting and transforming the essence of food and water, which is the source of qi and blood. It also governs the muscles of the limbs and is responsible for transforming the essence of food and water into qi and blood and distributing it throughout the body. If the spleen functions normally, the essence of food and water can be transformed into qi and blood. If the spleen is deficient and fails to transport and transform, the essence of food and water cannot be transformed normally and instead turns into fat and accumulates in the body, resulting in obesity. Therefore, in the TCM diagnosis of obesity, spleen deficiency and dampness are the core pathogenesis. Spleen deficiency and dampness obstruction type obesity is the most common type, while other types of obesity are also based on spleen deficiency as the underlying pathogenesis.

[0004] At the same time, drinking alcohol and eating meat have become commonplace in modern life, and cold drinks such as chilled beer, carbonated beverages, and milk tea are extremely popular. These dietary habits can not only lead to or aggravate spleen deficiency, causing damage to the liver, spleen, stomach, and intestines, but also induce various diseases or sub-health conditions such as gastritis, enteritis, indigestion, reflux esophagitis, hypertension, hyperlipidemia, hyperglycemia, hyperuricemia, fatty liver, and alcoholic liver, making the prevention and treatment of spleen deficiency and dampness-related obesity more complex and severe.

[0005] In existing technologies, Western medicine treatment for spleen deficiency and dampness-retention type obesity often uses prescription drugs. However, a single prescription drug cannot fully address the complex pathogenesis of spleen deficiency and dampness retention, and the combined use of multiple prescription drugs has the drawback of uncertain side effects. Moreover, prescription drugs cannot be used frequently in daily life, as the side effects of frequent use are unbearable, making it difficult to meet the actual needs of spleen deficiency and dampness-retention type obesity requiring cyclical treatment. Although traditional Chinese medicine is a good choice for treating spleen deficiency, the composition structure of currently available Chinese patent medicines is relatively simple. Spleen-strengthening, dampness-resolving, and digestion-aiding Chinese patent medicines are independent of each other, lacking functions of alcohol detoxification and liver protection. They do not fully consider the damage to the spleen and stomach caused by excessive drinking and eating meat in modern life. On the other hand, alcohol detoxification and liver protection products only focus on the effects of alcohol detoxification and liver protection, basically ignoring the problem of spleen deficiency and dampness caused by drinking and overeating. Neither of these approaches can systematically intervene in the core pathogenesis of spleen deficiency and dampness-retention type obesity.

[0006] Furthermore, when faced with a wide variety of traditional Chinese medicines in pharmacies, patients often do not know how to choose the right medicine for their own syndrome type, resulting in blind use of medicine, poor targeting, and poor efficacy. Although existing food and medicine products have good safety, they mostly focus on single effects, such as simply losing weight or simply strengthening the spleen. They fail to organically integrate multiple effects such as strengthening the spleen and replenishing qi, aromatically resolving dampness, promoting diuresis and reducing swelling, promoting digestion and relieving stagnation, relieving alcohol and protecting the liver, and replenishing qi and blood. They cannot comprehensively address the multiple pathological aspects that exist simultaneously in obese patients with spleen deficiency and dampness obstruction, such as spleen deficiency and impaired transportation, internal retention of dampness and turbidity, food stagnation and indigestion, liver damage from alcohol, and deficiency of qi and blood. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a food-medicine composition, preparation method and application for improving obesity of spleen deficiency and dampness obstruction type.

[0008] The technical solution of the present invention to solve the above-mentioned technical problems is as follows: This invention provides a medicinal and edible composition for improving obesity caused by spleen deficiency and dampness, made from the following raw materials in parts by weight: Codonopsis pilosula 20-40 parts, Dioscorea opposita 15-30 parts, Dolichos lablab 15-30 parts, Crataegus pinnatifida 10-20 parts, Hordeum vulgare 10-20 parts, Gallus gallus domesticus gizzard lining 10-20 parts, Hovenia dulcis 10-20 parts, Pueraria lobata 5-15 parts, Myristica fragrans 5-15 parts, Amomum villosum 5-15 parts, Vigna angularis 5-15 parts, Coix lacryma-jobi 15-25 parts, Pogostemon cablin 5-15 parts, Polygonatum odoratum 5-15 parts, Nelumbo nucifera leaf 10-20 parts, Citrus medica 5-15 parts, Citrus reticulata peel 5-15 parts, Lycium barbarum 5-15 parts, Longan aril 5-15 parts, Ganoderma lucidum 5-15 parts.

[0009] Based on the above technical solution, the present invention can be further improved as follows.

[0010] Furthermore, it is made from the following ingredients in parts by weight: Codonopsis pilosula 25-35 parts, Dioscorea opposita 20-26 parts, Dolichos lablab 20-26 parts, stir-fried hawthorn 13-18 parts, malt 13-18 parts, chicken gizzard lining 13-18 parts, Japanese raisin tree fruit 13-18 parts, Pueraria lobata 8-12 parts, nutmeg 8-12 parts, Amomum villosum 8-12 parts, red adzuki bean 8-12 parts, stir-fried coix seed 18-23 parts, Agastache rugosa 8-12 parts, Polygonatum odoratum 8-12 parts, lotus leaf 13-18 parts, Citrus medica 8-12 parts, dried tangerine peel 8-12 parts, wolfberry 8-12 parts, longan pulp 8-12 parts, Ganoderma lucidum 8-12 parts.

[0011] Furthermore, it is made from the following ingredients in parts by weight: 30 parts Codonopsis pilosula, 23 parts Dioscorea opposita, 23 parts white hyacinth bean, 15 parts stir-fried hawthorn, 15 parts malt, 15 parts chicken gizzard lining, 15 parts Japanese raisin tree fruit, 10 parts kudzu root, 10 parts nutmeg, 10 parts Amomum villosum, 10 parts red adzuki bean, 20 parts stir-fried coix seed, 10 parts agastache rugosa, 10 parts Polygonatum odoratum, 15 parts lotus leaf, 10 parts citronella, 10 parts dried tangerine peel, 10 parts wolfberry, 10 parts longan pulp, and 10 parts Ganoderma lucidum.

[0012] This invention also provides a method for preparing the above-described food-medicine composition for improving spleen deficiency and dampness-retention type obesity, comprising the following steps: S1. Weigh each raw material according to the weight parts, clean and dry them, then crush them for later use; S2. Soak the raw material obtained in step S1 in water, decoct and extract, filter, and combine the filtrates. S3. Concentrate the filtrate to obtain the composition.

[0013] Furthermore, in step S2, the soaking time is 30 to 60 minutes; the decoction extraction is performed 2 to 3 times, with the amount of water added each time being 6 to 10 times the total weight of the raw materials, and each decoction lasting 1 to 2 hours.

[0014] Furthermore, in step S3, the concentration is carried out under reduced pressure, with a temperature of 40-80℃, a vacuum degree of -0.04 to -0.08 MPa, and a time of 10-60 minutes.

[0015] Furthermore, after concentration, the process also includes drying and pulverizing steps.

[0016] Furthermore, the drying process is either vacuum drying or spray drying.

[0017] The present invention also provides the application of the above-described food-medicine homology composition in the preparation of formulations for improving spleen deficiency and dampness-retention type obesity.

[0018] The present invention also provides a preparation for improving obesity of spleen deficiency and dampness obstruction type. The preparation is an oral preparation, and the dosage form is oral liquid, solid beverage, compressed candy, pill, powder or paste.

[0019] The beneficial effects of this invention are as follows: (1) The food-medicine composition of the present invention for improving spleen deficiency and dampness obstruction type obesity has the core function of strengthening the spleen and replenishing qi. By using Codonopsis pilosula and Dioscorea opposita to replenish the qi of the spleen and lungs, it provides the spleen and stomach with the power of transportation and transformation, so that the spleen can effectively transport and transform to generate qi and blood and not generate dampness. It fundamentally improves the core pathogenesis of obesity caused by spleen deficiency and failure to transport and transform the essence of water and grain into fat and stagnation in the body. (2) The food and medicine composition of the present invention for improving spleen deficiency and dampness obstruction type obesity has the effects of aromatic dampness removal, spleen strengthening and diarrhea stopping. Through the combined action of white hyacinth bean, agastache, amomum villosum and nutmeg, it targets the symptoms of fatigue, loss of appetite and sticky stool caused by spleen deficiency and dampness, removes dampness and turbidity in the body to reduce fat and restores the normal digestive function of the spleen and stomach. (3) The food and medicine composition of the present invention for improving spleen deficiency and dampness obstruction type obesity can promote diuresis and reduce fat. Through the synergistic effect of stir-fried coix seed, red adzuki bean and jujube seed, it promotes the excretion of water and dampness through urine, eliminates edema, and reduces weight gain and body swelling caused by water and dampness stagnation. (4) The food-medicine composition of the present invention for improving spleen deficiency and dampness obstruction type obesity has the function of promoting digestion and eliminating stagnation. It eliminates meat stagnation by stir-frying hawthorn, eliminates rice and noodle stagnation by malt, and eliminates various food stagnation by chicken gizzard. The three medicines work together to strongly promote digestion, eliminate abdominal distension, prevent spleen deficiency caused by overeating or aggravate spleen deficiency, and block the cause of obesity caused by irregular diet. (5) The food and medicine composition of the present invention for improving obesity caused by spleen deficiency and dampness can detoxify alcohol, protect the liver and stomach, accelerate alcohol metabolism through the synergistic effect of Hovenia dulcis and Pueraria lobata, relieve thirst, headache and stomach discomfort after drinking, prevent obesity caused by drinking or aggravate obesity, and adapt to the characteristics of normal drinking in modern life. (6) The food-medicine composition of the present invention for improving spleen deficiency and dampness-obstruction type obesity is composed of food-medicine ingredients, which is mild and balanced. It has both the nutritional function of food and the function of regulating the body's health. It is safe and has few side effects. It can be taken frequently in daily life to meet the actual needs of spleen deficiency and dampness-obstruction type obesity that needs to be regulated according to the cycle. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the preparation process of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity of the present invention. Detailed Implementation

[0021] The principles and features of the present invention are described below. The examples given are only for explaining the present invention and are not intended to limit the scope of the present invention.

[0022] The present invention provides a medicinal and edible composition for improving obesity caused by spleen deficiency and dampness, which is made from the following raw materials in parts by weight: 20-40 parts of Codonopsis pilosula, 15-30 parts of Dioscorea opposita, 15-30 parts of Dolichos lablab, 10-20 parts of stir-fried Crataegus pinnatifida, 10-20 parts of malt, 10-20 parts of chicken gizzard lining, 10-20 parts of Hovenia dulcis, 5-15 parts of Pueraria lobata, 5-15 parts of nutmeg, 5-15 parts of Amomum villosum, 5-15 parts of red adzuki bean, 15-25 parts of stir-fried Coix lacryma-jobi, 5-15 parts of Pogostemon cablin, 5-15 parts of Polygonatum odoratum, 10-20 parts of Nelumbo nucifera leaf, 5-15 parts of Citrus medica var. sarcodactylis, 5-15 parts of dried tangerine peel, 5-15 parts of Lycium barbarum, 5-15 parts of longan pulp, and 5-15 parts of Ganoderma lucidum.

[0023] The medicinal and edible composition of the present invention for improving spleen deficiency and dampness-retention type obesity takes strengthening the spleen and replenishing qi as its core, and takes into account multiple effects such as aromatic dampness-resolving, diuresis and swelling reduction, digestion and stagnation relief, alcohol detoxification and liver protection, clearing the upper and lowering the lower, warming the middle and stopping diarrhea, soothing the liver and regulating qi, replenishing qi and blood, and nourishing yin and generating fluids. Through the synergistic combination of twenty medicinal and edible ingredients, a systematic intervention program targeting the core pathogenesis of spleen deficiency and dampness-retention type obesity and the inducements of modern lifestyle is formed, achieving the comprehensive effects of strengthening the body, eliminating pathogens, relieving fatigue, enhancing human immunity, and effectively assisting in weight loss.

[0024] This formula takes strengthening the spleen and replenishing qi as the fundamental treatment strategy. Codonopsis pilosula and Dioscorea opposita are the chief herbs to replenish the qi of the spleen and lungs to restore the digestive function of the spleen and stomach, so that the essence of food can be transformed into qi and blood normally instead of stagnating into fat. For the symptoms of spleen deficiency and dampness, white hyacinth bean, agastache rugosa, amomum villosum and nutmeg are used to aromatically resolve dampness, strengthen the spleen and stop diarrhea. Fried coix seed, red adzuki bean and jujube fruit promote diuresis and reduce swelling. Lotus leaf promotes the clear yang, clears summer heat and removes dampness from the body through multiple pathways.

[0025] In response to the characteristics of modern unhealthy diets, this formula uses stir-fried hawthorn to eliminate food stagnation caused by meat, malt to eliminate food stagnation caused by rice and noodles, and chicken gizzard lining to eliminate various types of food stagnation. The three herbs work together to strongly promote digestion, eliminate abdominal distension, and prevent overeating from aggravating spleen deficiency. Addressing the common modern lifestyle of alcohol damaging the liver and spleen, this formula uses Hovenia dulcis and Pueraria lobata as the core herb pair for alcohol detoxification, accelerating alcohol metabolism, detoxifying alcohol, protecting the liver and stomach, and preventing or exacerbating obesity caused by alcohol consumption. For the pathogenesis of dampness obstructing qi and disrupting the ascending and descending functions, this formula uses Amomum villosum, Pogostemon cablin, Citrus reticulata peel, and Myristica fragrans to warm the middle jiao, dispel cold, stop vomiting and diarrhea, improve abdominal distension and reflux, and solidify stools. Citrus reticulata peel and Citrus medica var. sarcodactylis soothe the liver, regulate qi, harmonize the stomach, and relieve pain, preventing qi stagnation and abdominal distension. This formula nourishes without causing stagnation. Kudzu root and lotus leaf promote the spleen's upward movement of clear qi, further generating qi and blood. For the concurrent symptoms of prolonged spleen deficiency and qi and blood deficiency, codonopsis and ganoderma lucidum are used to replenish qi, calm the mind, and improve immunity. Longan pulp, wolfberry, and codonopsis nourish blood, calm the mind, and tonify the liver and kidneys. On the basis of strengthening the spleen and replenishing qi, it promotes the generation of qi and blood. Sufficient qi and blood lead to normal metabolism, which is beneficial for weight loss. To address the concern that diuresis and dampness removal may damage yin, polygonatum odoratum, kudzu root, and yam are used to nourish yin, generate fluids, and quench thirst, preventing excessive dampness removal from damaging yin fluids. The entire formula combines tonification and purgation, promotes the ascending and descending of qi, regulates qi and blood, and balances yin and yang. It treats both the root cause and the symptoms, eliminating pathogens without harming the body's vital energy, demonstrating the exquisite combination of traditional Chinese medicine formulas.

[0026] Specifically, Codonopsis pilosula is sweet and neutral in nature, and enters the spleen and lung meridians. It tonifies the spleen and lung qi, nourishes blood and generates body fluids, and provides the spleen and stomach with the power for digestion and transformation. When the spleen's digestion and transformation are strong, it generates qi and blood without generating dampness, thus fundamentally improving the retention of fat caused by spleen deficiency and impaired digestion. Dioscorea opposita is sweet and neutral in nature, and enters the spleen, lung and kidney meridians. It tonifies qi and nourishes yin, and tonifies the spleen, lung and kidney. Together with Codonopsis pilosula, it enhances the spleen-strengthening and qi-tonifying effects, and provides continuous power for the spleen and stomach's digestion and transformation.

[0027] White hyacinth bean is sweet in flavor and slightly warm in nature, acts on the spleen and stomach meridians, tonifies spleen qi and resolves dampness, directly targeting the syndrome of spleen deficiency with dampness stagnation, and enhancing the spleen's function of transporting and transforming water-dampness; Fried hawthorn is sour and sweet in flavor and slightly warm in nature, acts on the spleen, stomach and liver meridians, promotes digestion to remove food stagnation and activates blood circulation to dissipate blood stasis, is especially good at resolving meat food stagnation, and targets the characteristics of modern people's high-fat diet to prevent meat food stagnation from aggravating spleen deficiency and dampness obstruction; Malt is sweet in flavor and neutral in nature, acts on the spleen, stomach and liver meridians, promotes digestion and strengthens the stomach, is especially good at resolving stagnation from rice and wheat food, and forms a digestant herb group with hawthorn and chicken's gizzard membrane to comprehensively address all kinds of food stagnation; Chicken's gizzard membrane is sweet in flavor and neutral in nature, acts on the spleen, stomach, small intestine and bladder meridians, promotes digestion and strengthens the stomach, resolves hardness and eliminates stones, and has good effects on all kinds of food stagnation. The combined use of these three herbs can strongly promote digestion, eliminate abdominal distension and fullness, and prevent spleen deficiency caused by excessive diet or aggravation of existing spleen deficiency; Hovenia dulcis is sweet and sour in flavor and neutral in nature, acts on the spleen meridian, resolves alcoholic toxins, promotes urination to reduce edema, and relieves thirst and restlessness. It is a key herb for resolving hangover, can accelerate alcohol metabolism, relieve thirst, headache and stomach discomfort after drinking, and has the effects of resolving alcoholic toxins, protecting the liver and stomach, promoting urination to reduce edema and reducing fat; Kudzu root is sweet and pungent in flavor and cool in nature, acts on the spleen, stomach and lung meridians, elevates yang to stop diarrhea, promotes the production of body fluids to quench thirst, and relieves exterior syndrome and reduces fever. It works synergistically with Hovenia dulcis to resolve hangover and invigorate the spleen, elevates clear yang to alleviate the symptoms of phlegm clouding the clear orifices and dizziness after drinking, has the effect of refreshing the mind, and can nourish yin and promote the production of body fluids to prevent fluid consumption caused by diuresis; Nutmeg is pungent in flavor and warm in nature, acts on the spleen, stomach and large intestine meridians, warms the middle energizer to move qi, and astringes the intestine to stop diarrhea. It targets deficient diarrhea and cold dysentery, cold pain and distention in the stomach, and poor appetite and vomiting caused by spleen-stomach deficiency cold, and warms the middle to dispel cold to improve abdominal distension and regurgitation, and make the stool formed.

[0028] Amomum villosum is pungent in flavor and warm in nature, acts on the spleen, stomach and kidney meridians, resolves dampness and moves qi, warms the middle energizer to stop diarrhea, targets dampness obstruction and qi stagnation in the spleen and stomach as well as vomiting and diarrhea due to spleen-stomach deficiency-cold, resolves dampness with its aroma to reduce fat, and warms and moves qi in the middle energizer to assist transportation and transformation; Adzuki bean is sweet and sour in flavor and neutral in nature, acts on the heart and small intestine meridians, promotes diuresis to reduce edema, drains dampness to relieve jaundice, and detoxifies and expels pus, and it synergizes with fried coix seed and Hovenia dulcis to enhance the effect of promoting diuresis and reducing edema, so as to promote the discharge of damp turbidity through urine; Fried coix seed is sweet and bland in flavor and slightly cold in nature, acts on the spleen, stomach and lung meridians, exerts the effects of permeating dampness and promoting diuresis, invigorating the spleen to stop diarrhea, and clearing heat and expelling pus, and it invigorates the spleen and promotes diuresis simultaneously, which not only assists the spleen in transportation and transformation but also directly eliminates water dampness, targeting edema and diarrhea caused by spleen deficiency and exuberant dampness; Agastache rugosus is pungent in flavor and slightly warm in nature, acts on the spleen, stomach and lung meridians, resolves dampness, stops vomiting and releases the exterior, and it resolves dampness with its aroma to awaken the spleen, targets dampness obstructing the middle energizer and vomiting, and improves loss of appetite caused by spleen deficiency and exuberant dampness; Polygonatum odoratum is sweet in flavor and slightly cold in nature, acts on the lung and stomach meridians, nourishes yin to moisten the lung, and benefits the stomach to promote fluid production, and it prevents the yin-damaging effect of the diuresis-promoting and dampness-permeating ingredients in the formula, and nourishes yin and promotes fluid production to protect stomach yin; Lotus leaf is bitter and astringent in flavor and neutral in nature, acts on the heart, liver and spleen meridians, elevates clear yang, and clears summer heat and drains dampness, and it promotes the spleen to elevate the clear so as to generate qi and blood, and drains damp turbidity to assist weight loss; Finger citron is pungent and bitter in flavor and warm in nature, acts on the liver, spleen, stomach and lung meridians, soothes the liver to regulate qi, moves qi to harmonize the middle energizer, and dries dampness to resolve phlegm, and it soothes the liver and harmonizes the stomach to prevent qi stagnation and abdominal distension, prevents tonification from causing stagnation, and enhances the transportation and transformation function of the spleen and stomach; Tangerine peel is pungent and bitter in flavor and warm in nature, acts on the spleen and lung meridians, moves qi to stop vomiting, and dries dampness to resolve phlegm, and it synergizes with finger citron to soothe the liver and regulate qi, harmonize the stomach to relieve pain, and dry dampness to resolve phlegm so as to assist in eliminating damp turbidity in the body; Chinese wolfberry is sweet in flavor and neutral in nature, acts on the liver and kidney meridians, tonifies the liver and kidney, benefits essence and blood, and improves eyesight, and it tonifies the liver and kidney on the basis of invigorating the spleen and replenishing qi to promote the generation of qi and blood; Longan aril is sweet in flavor and warm in nature, acts on the heart and spleen meridians, tonifies and benefits the heart and spleen, and nourishes blood to calm the mind, targets heart-spleen deficiency and damage as well as qi and blood insufficiency, and nourishes blood to calm the mind on the basis of invigorating the spleen; Ganoderma lucidum is sweet in flavor and neutral in nature, acts on the heart, lung, liver and kidney meridians, tonifies qi to calm the mind, relieves cough and suppresses panting, and protects the liver and benefits the kidney, and it tonifies qi to calm the mind so as to improve immunity, support healthy qi, protect the liver, and improve the overall state.

[0029] Preferably, this food-medicine homologous composition is prepared from the following raw materials in parts by weight: 25 to 35 parts of Codonopsis pilosula, 20 to 26 parts of Chinese yam, 20 to 26 parts of white hyacinth bean, 13 to 18 parts of fried hawthorn, 13 to 18 parts of malt, 13 to 18 parts of chicken's gizzard membrane, 13 to 18 parts of Hovenia dulcis, 8 to 12 parts of kudzu root, 8 to 12 parts of nutmeg, 8 to 12 parts of Amomum villosum, 8 to 12 parts of adzuki bean, 18 to 23 parts of fried coix seed, 8 to 12 parts of Agastache rugosus, 8 to 12 parts of Polygonatum odoratum, 13 to 18 parts of lotus leaf, 8 to 12 parts of finger citron, 8 to 12 parts of tangerine peel, 8 to 12 parts of Chinese wolfberry, 8 to 12 parts of longan aril, and 8 to 12 parts of Ganoderma lucidum.

[0030] Further, the optimal parts by mass of each component in this food-medicine homologous composition are: 30 parts of Codonopsis pilosula, 23 parts of Chinese yam, 23 parts of white hyacinth bean, 15 parts of fried hawthorn, 15 parts of malt, 15 parts of chicken's gizzard membrane, 15 parts of Hovenia dulcis, 10 parts of kudzu root, 10 parts of nutmeg, 10 parts of Amomum villosum, 10 parts of adzuki bean, 20 parts of fried coix seed, 10 parts of Agastache rugosus, 10 parts of Polygonatum odoratum, 15 parts of lotus leaf, 10 parts of finger citron, 10 parts of tangerine peel, 10 parts of Chinese wolfberry, 10 parts of longan aril, and 10 parts of Ganoderma lucidum.

[0031] The preparation method of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity of the present invention includes the following steps: S1. Weigh each raw material according to the weight parts, clean and dry them, then crush them for later use; S2. Soak the raw material obtained in step S1 in water, decoct and extract, filter, and combine the filtrates.

[0032] Preferably, the soaking time is 30 to 60 minutes; the number of decoction extractions is 2 to 3 times, with the amount of water added each time being 6 to 10 times the total weight of the raw materials, and each decoction lasting 1 to 2 hours.

[0033] S3. Concentrate the filtrate to obtain the composition.

[0034] Preferably, the concentration is carried out under reduced pressure, at a temperature of 40-80℃, a vacuum degree of -0.04 to -0.08 MPa, and for a time of 10-60 minutes.

[0035] Preferably, after concentration, the process also includes drying and pulverizing steps.

[0036] Preferably, the drying method is vacuum drying or spray drying.

[0037] The preparation of the present invention for improving obesity of spleen deficiency and dampness obstruction type is specifically an oral preparation, and the dosage form of the oral preparation is oral liquid, solid beverage, compressed candy, pill, powder or paste.

[0038] Oral liquid formulations are easy to absorb and have a rapid onset of action, making them suitable for obese patients with spleen deficiency and dampness retention, who have weak spleen and stomach function and poor digestive and absorptive capacity. The liquid form is easy to take and can be absorbed by the gastrointestinal tract without undergoing a complex disintegration process, allowing it to quickly exert its effects of strengthening the spleen and replenishing qi, and aromatically resolving dampness. Solid beverage formulations are easy to carry and prepare, adapting to the fast-paced lifestyle of modern people. Patients can take it anytime and anywhere with warm water, ensuring both the convenience of medication and the stability of the food-medicine homology ingredients.

[0039] Compressed candy has a pleasant taste and is convenient to take. Modern pharmaceutical processes have improved upon the bitterness and difficulty in swallowing traditional Chinese medicine, increasing patient compliance. It is especially suitable for obese individuals with spleen deficiency and dampness retention who require cyclical treatment. Pills have a mild and long-lasting effect and are easy to store. Pills release slowly in the body and have a long duration of effect, which meets the treatment characteristics of long-term, slow treatment for obesity caused by spleen deficiency and dampness retention. In addition, pills are small in size, making them easy to carry and store. Powders have a simple preparation process and flexible administration. The dosage can be adjusted according to the patient's specific condition. Powders can be taken directly or added to decoctions, preserving the original medicinal properties of the herbs. Paste has a thick texture and strong nourishing power. Pastes are concentrated through long-term simmering, resulting in a mild medicinal property and specific nourishing power. They are especially suitable for obese patients with long-term spleen deficiency and significant qi and blood deficiency. While strengthening the spleen and removing dampness, they also nourish qi and blood. In addition, pastes have a sweet taste and are easy to accept.

[0040] The effects of the present invention will be illustrated by specific embodiments below.

[0041] Example 1 The preparation method of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity in this embodiment is as follows: Take 30 parts of Codonopsis pilosula, 20 parts of Dioscorea opposita, 20 parts of white hyacinth bean, 15 parts of stir-fried hawthorn, 15 parts of malt, 15 parts of chicken gizzard lining, 15 parts of Hovenia dulcis, 10 parts of Pueraria lobata, 10 parts of nutmeg, 10 parts of Amomum villosum, 10 parts of red adzuki bean, 20 parts of stir-fried Coix lacryma-jobi, 10 parts of Pogostemon cablin, 10 parts of Polygonatum odoratum, 15 parts of lotus leaf, 10 parts of Citrus medica, 10 parts of dried tangerine peel, 10 parts of wolfberry, 10 parts of longan pulp, and 10 parts of Ganoderma lucidum. Clean and mix the above ingredients separately, add water equal to 8 times the total weight of the ingredients and soak for 2 hours, then heat and decoct for 2 hours. Filter and collect the filtrate. Add water equal to 6 times the weight of the dregs and continue to decoct for 1.5 hours. Filter and combine the two filtrates, concentrate under reduced pressure to a clear extract with a relative density of 1.05-1.10, add appropriate excipients, sterilize and fill into oral liquid, each bottle containing 10ml.

[0042] Ms. Zhang, 53 years old, 168cm tall, 76kg, BMI 26.9, waist circumference 98cm, runs a cosmetics company. Due to work, she frequently attends social events, resulting in obesity. Symptoms included soft muscles, abdominal distension, which worsened after meals, frequent loose stools, heaviness in the limbs, and swelling of the upper eyelids upon waking. She was diagnosed with spleen deficiency and dampness obstruction type obesity. She used the oral liquid prepared in this embodiment, taking one vial each morning and evening for 21 days. Her abdominal distension improved significantly, her stools became formed, her weight decreased to 73kg, and her waist circumference decreased to 88cm. Both her weight and waist circumference showed significant improvement.

[0043] Example 2 The preparation method of the medicinal and edible composition for improving spleen deficiency and dampness-induced obesity in this embodiment is as follows: Take 25 parts of Codonopsis pilosula, 25 parts of Dioscorea opposita, 25 parts of white hyacinth bean, 12 parts of stir-fried hawthorn, 12 parts of malt, 12 parts of chicken gizzard lining, 12 parts of Hovenia dulcis, 8 parts of Pueraria lobata, 8 parts of nutmeg, 8 parts of Amomum villosum, 8 parts of red adzuki bean, 18 parts of stir-fried Coix lacryma-jobi, 8 parts of Agastache rugosa, 8 parts of Polygonatum odoratum, 12 parts of lotus leaf, 8 parts of Citrus medica, 8 parts of dried tangerine peel, 8 parts of wolfberry, 8 parts of longan pulp, and 8 parts of Ganoderma lucidum. Clean and dry the above raw materials, pulverize them into fine powder, pass them through an 80-mesh sieve, mix them evenly, add 0.5 times the total weight of the raw materials of dextrin and an appropriate amount of sweetener, use ethanol as a wetting agent to make a soft material, pass it through a 14-mesh sieve to granulate, dry it at 60°C, and then granulate it into 5g bags of solid beverage.

[0044] Mr. Qiu, male, 49 years old, had been experiencing abdominal pain and diarrhea for 5 years, with symptoms varying in severity. He was 173cm tall and weighed only 49.8kg. The diagnoses from multiple hospitals were inconsistent. The patient used the solid beverage prepared in this example, taking one packet twice a day, morning and evening, for 60 days. After 35 days, the abdominal pain disappeared and the diarrhea was significantly reduced. After 50 days, he had no diarrhea problems for 10 consecutive days. The patient was very satisfied with his recovery.

[0045] Example 3 The preparation method of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity in this embodiment is as follows: Take 35 parts of Codonopsis pilosula, 18 parts of Dioscorea opposita, 18 parts of white hyacinth bean, 18 parts of stir-fried hawthorn, 18 parts of malt, 18 parts of chicken gizzard lining, 18 parts of Hovenia dulcis, 12 parts of kudzu root, 12 parts of nutmeg, 12 parts of Amomum villosum, 12 parts of red adzuki bean, 22 parts of stir-fried Coix lacryma-jobi, 12 parts of Agastache rugosa, 12 parts of Polygonatum odoratum, 18 parts of lotus leaf, 12 parts of Citrus medica, 12 parts of dried tangerine peel, 12 parts of wolfberry, 12 parts of longan pulp, and 12 parts of Ganoderma lucidum. [The rest of the text appears to be a continuation of the previous sentence.] The raw materials are cleaned and mixed separately. They are then soaked in water at a volume 10 times their total weight for 3 hours, then heated and decocted for 3 hours. The filtrate is collected by filtration. The dregs are then decocted in water at a volume 8 times their total weight for another 2 hours. The filtrates from both filtrations are combined and concentrated under reduced pressure to a thick paste with a relative density of 1.20–1.25. An appropriate amount of sucrose and refined honey are added and boiled to make a paste. Each bottle contains 200g. Take 15g twice a day, morning and evening, with warm water.

[0046] Ms. Xu, 45 years old, 155cm tall, weighing 71kg, with a BMI of 29.6 and a waist circumference of 106cm, had been trying to lose weight, but her weight fluctuated and she had not succeeded. Her symptoms included a soft and thick abdomen, weak and sagging muscles, feeling heavy and lethargic, drinking little water, having a lot of phlegm, and a large tongue with teeth marks. She was diagnosed with obesity due to spleen deficiency and dampness obstruction. She used the paste prepared in this example, taking 15g twice a day, morning and evening, dissolved in warm water. After 28 days of treatment, her weight decreased to 67kg and her waist circumference decreased to 90cm, showing significant improvement in both weight and waist circumference.

[0047] Example 4 The preparation method of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity in this embodiment is as follows: Take 22 parts of Codonopsis pilosula, 28 parts of Dioscorea opposita, 22 parts of white hyacinth bean, 10 parts of stir-fried hawthorn, 10 parts of malt, 10 parts of chicken gizzard lining, 10 parts of Japanese raisin tree fruit, 15 parts of kudzu root, 15 parts of nutmeg, 15 parts of Amomum villosum, 15 parts of red adzuki bean, 15 parts of stir-fried coix seed, 15 parts of agastache rugosa, 15 parts of Polygonatum odoratum, 10 parts of lotus leaf, 15 parts of Citrus medica, 15 parts of dried tangerine peel, 15 parts of wolfberry, 15 parts of longan pulp, and 15 parts of Ganoderma lucidum. Clean and dry the above raw materials separately, then grind them into fine powder, pass them through a 100-mesh sieve, mix them evenly, add 0.3 times the total weight of the raw materials of microcrystalline cellulose and an appropriate amount of magnesium stearate, granulate with ethanol as a binder, dry and compress into tablets to make 0.5g tablets.

[0048] Mr. Tang, male, 35 years old, is a senior executive in a company, responsible for market expansion. He often drinks alcohol due to social engagements. Years of high-intensity work have caused him to develop moderate alcoholic fatty liver disease, with symptoms including abdominal distension, bitter taste in the mouth, dry throat, belching, and acid reflux. He used the compressed candy prepared in this example, taking 4 tablets each morning and evening for 2 months. His alcoholic fatty liver disease decreased from moderate to mild, and his symptoms of bitter taste in the mouth, dry throat, and abdominal distension disappeared. His belching and acid reflux also improved significantly.

[0049] Example 5 The preparation method of the food-medicine homology composition for improving spleen deficiency and dampness-retention type obesity in this embodiment is as follows: Take 40 parts of Codonopsis pilosula, 15 parts of Dioscorea opposita, 30 parts of white hyacinth bean, 20 parts of stir-fried hawthorn, 20 parts of malt, 20 parts of chicken gizzard lining, 20 parts of Hovenia dulcis, 5 parts of Pueraria lobata, 5 parts of nutmeg, 5 parts of Amomum villosum, 5 parts of red adzuki bean, 25 parts of stir-fried Coix lacryma-jobi, 5 parts of Agastache rugosa, 5 parts of Polygonatum odoratum, 20 parts of lotus leaf, 5 parts of Citrus medica, 5 parts of dried tangerine peel, 5 parts of wolfberry, 5 parts of longan pulp, and 5 parts of Ganoderma lucidum. Clean and dry the above raw materials separately, then grind them into fine powder, pass them through a 120-mesh sieve, mix them evenly, use refined honey as a binder, and prepare water-honey pills using the pill-making method. After drying at 60℃, polish them to make pills with each pill weighing 0.3g.

[0050] Ms. Wei, 65 years old, suffered from poor appetite, a bland and sticky taste in her mouth, abdominal distension after meals, loose stools, and was prone to edema. She was particularly troubled by feeling heavy and sluggish. She used the pills prepared in this example, taking 6g twice a day, morning and evening, for 15 days. Her abdominal distension was basically improved, her appetite was significantly improved after 30 days, and she no longer felt heavy and sluggish after 60 days. The patient was very happy.

[0051] It can be seen that the above 5 patients were treated with oral liquid, solid beverage, paste, compressed candy and pill respectively, and all of them were effectively improved with spleen deficiency and dampness obstruction type obesity and related symptoms, which proves that the composition is applicable to multiple dosage forms and has a definite curative effect.

[0052] Although embodiments of the present invention have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting the present invention. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of the present invention.

Claims

1. A medicinal and edible composition for improving obesity caused by spleen deficiency and dampness retention, characterized in that, It is made from the following ingredients in parts by weight: Codonopsis pilosula 20-40 parts, Dioscorea opposita 15-30 parts, Dolichos lablab 15-30 parts, Crataegus pinnatifida 10-20 parts, Hordeum vulgare 10-20 parts, Chicken gizzard lining 10-20 parts, Hovenia dulcis 10-20 parts, Pueraria lobata 5-15 parts, Myristica fragrans 5-15 parts, Amomum villosum 5-15 parts, Vigna angularis 5-15 parts, Coix lacryma-jobi 15-25 parts, Pogostemon cablin 5-15 parts, Polygonatum odoratum 5-15 parts, Nelumbo nucifera leaf 10-20 parts, Citrus medica 5-15 parts, Citrus reticulata peel 5-15 parts, Lycium barbarum 5-15 parts, Longan pulp 5-15 parts, Ganoderma lucidum 5-15 parts.

2. The medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 1, characterized in that, It is made from the following ingredients in parts by weight: Codonopsis pilosula 25-35 parts, Dioscorea opposita 20-26 parts, Dolichos lablab 20-26 parts, stir-fried hawthorn 13-18 parts, malt 13-18 parts, chicken gizzard lining 13-18 parts, Japanese raisin tree fruit 13-18 parts, Pueraria lobata 8-12 parts, nutmeg 8-12 parts, Amomum villosum 8-12 parts, red adzuki bean 8-12 parts, stir-fried coix seed 18-23 parts, Agastache rugosa 8-12 parts, Polygonatum odoratum 8-12 parts, lotus leaf 13-18 parts, Citrus medica 8-12 parts, dried tangerine peel 8-12 parts, wolfberry 8-12 parts, longan pulp 8-12 parts, Ganoderma lucidum 8-12 parts.

3. The medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 2, characterized in that, Made from the following ingredients in parts by weight: Codonopsis pilosula 30 parts, Dioscorea opposita 23 parts, Dolichos lablab 23 parts, stir-fried hawthorn 15 parts, malt 15 parts, chicken gizzard lining 15 parts, Japanese raisin tree fruit 15 parts, kudzu root 10 parts, nutmeg 10 parts, Amomum villosum 10 parts, red adzuki bean 10 parts, stir-fried coix seed 20 parts, agastache rugosa 10 parts, Polygonatum odoratum 10 parts, lotus leaf 15 parts, Citrus medica 10 parts, dried tangerine peel 10 parts, wolfberry 10 parts, longan pulp 10 parts, Ganoderma lucidum 10 parts.

4. A method for preparing a medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity as described in any one of claims 1 to 3, characterized in that, Includes the following steps: S1. Weigh each raw material according to the weight parts, clean and dry them, then crush them for later use; S2. Soak the raw material obtained in step S1 in water, decoct and extract, filter, and combine the filtrates. S3. Concentrate the filtrate to obtain the composition.

5. The method for preparing a medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 4, characterized in that, In step S2, the soaking time is 30-60 minutes; the decoction extraction is performed 2-3 times, with the amount of water added each time being 6-10 times the total weight of the raw materials, and each decoction lasting 1-2 hours.

6. The method for preparing a medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 4, characterized in that, In step S3, the concentration is carried out under reduced pressure, with a temperature of 40-80℃, a vacuum degree of -0.04 to -0.08 MPa, and a time of 10-60 minutes.

7. The method for preparing a medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 4, characterized in that, After concentration, the process also includes drying and pulverizing steps.

8. A method for preparing a medicinal and edible composition for improving spleen deficiency and dampness-retention type obesity according to claim 7, characterized in that, The drying process is either vacuum drying or spray drying.

9. The use of the food-medicine homology composition according to any one of claims 1-3 in the preparation of an agent for improving spleen deficiency and dampness-retention type obesity.

10. A preparation for improving obesity caused by spleen deficiency and dampness retention, characterized in that, The preparation is an oral preparation, and the dosage form is oral liquid, solid beverage, compressed candy, pill, powder or paste.

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