An external preparation for promoting qi and penetrating skin for adapting to massage conditioning, a preparation method and application thereof

Abstract

The application provides an external preparation for promoting qi and transdermal administration, a preparation method and application thereof, and relates to the technical field of external preparations of traditional Chinese medicine, and is prepared from the following raw materials: frankincense, myrrh, camphor, angelica sinensis, ligusticum chuanxiong, rhizoma sparganii, zedoary turmeric, honeysuckle, silk gourd, a transdermal enhancer and an excipient; the application is based on the theory of yin and yang integration in traditional Chinese medicine, and combines the pungent and spicy and transdermal qi-promoting of yang drugs with the bitter and cold and blood-activating and knot-dissolving of yin drugs, so that the compatibility principle of yin and yang pairing and integration is embodied, and the application is more comprehensive and balanced than a single-effect formula in the prior art.

Description

Technical Field

[0001] This invention relates to the field of external preparations of traditional Chinese medicine, and in particular to a transdermal preparation for promoting qi circulation and conditioning, its preparation method and application. Background Technology

[0002] Massage mediums, also known as massage agents, are substances applied to the skin surface of the treatment area during massage to lubricate and protect the skin. Traditional massage mediums come in many varieties, including powders (such as talcum powder and baby powder), oils (such as sesame oil and petroleum jelly), liquids (such as medicinal solutions and medicated wines), and ointments (such as medicated creams and massage creams). Different types of mediums have different physical properties and are suitable for different massage techniques and treatment scenarios.

[0003] To improve the transdermal absorption efficiency of drugs, various permeation enhancement methods have been developed in the existing technology, including chemical permeation enhancement, physical permeation enhancement, and pharmaceutical methods. However, chemical permeation enhancers may cause skin irritation or allergies; physical permeation enhancement requires specialized equipment and is complex to operate, making it unsuitable for daily massage therapy; and nanocarrier systems have complex preparation processes, high costs, and potential safety risks.

[0004] Massage techniques themselves have a certain physical penetration-enhancing effect. The kneading, pressing, pushing, and grasping techniques during massage exert mechanical forces on the skin, including pressure, shear force, and friction. These mechanical stimuli can cause temporary changes in the structure of the stratum corneum, increase skin permeability, and promote the transdermal absorption of drugs.

[0005] However, there are few topical preparations in the existing technology specifically designed for the penetration-enhancing effect of massage. Most Chinese herbal topical preparations are designed based on static transdermal absorption and do not take into account the drug release and transdermal behavior under the mechanical action of massage techniques. As a result, in actual massage applications, the drug release is too fast or too slow and cannot form the best synergy with the massage operation. Summary of the Invention

[0006] The purpose of this invention is to provide a transdermal topical preparation adapted for massage therapy, its preparation method, and its application, thereby solving the technical problems existing in the prior art.

[0007] To achieve the above-mentioned objectives, the technical solution adopted by this invention is as follows: A transdermal topical preparation suitable for massage therapy, its preparation method, and its application, comprising the following raw materials: Yang-type medicinal components: 10-25 parts frankincense, 10-25 parts myrrh, 3-10 parts camphor, 15-30 parts angelica sinensis, and 15-30 parts chuanxiong rhizome; Yin-type medicinal components: 10-25 parts sparganium rhizome, 10-25 parts turmeric rhizome, 20-40 parts honeysuckle vine, and 15-35 parts loofah sponge; wherein the weight ratio of the Yang-type medicinal components to the Yin-type medicinal components is 1:0.8-1.2.

[0008] Furthermore, the raw materials are in the following weight proportions: Yang-type components: frankincense 15-20 parts, myrrh 15-20 parts, camphor 5-8 parts, angelica 20-25 parts, chuanxiong 20-25 parts; Yin-type components: sparganium 15-20 parts, turmeric 15-20 parts, honeysuckle vine 25-35 parts, loofah sponge 20-30 parts.

[0009] Furthermore, the raw materials are in the following weight proportions: Yang-type components: frankincense 18 parts, myrrh 17 parts, camphor 7 parts, angelica 22 parts, chuanxiong 23 parts; Yin-type components: sparganium 17 parts, turmeric 18 parts, honeysuckle vine 30 parts, loofah sponge 25 parts.

[0010] Furthermore, it also includes a topical matrix, which is any one of a massage oil matrix, a cream matrix, or a gel matrix.

[0011] Furthermore, it also includes transdermal penetration enhancers and excipients, wherein the transdermal penetration enhancer is one or more combinations of azone, propylene glycol, menthol, borneol, and β-caryophyllene; the weight of the transdermal penetration enhancer accounts for 0.5% to 5% of the total weight of the formulation; and the excipient is one of grass flavoring or rose flavoring.

[0012] Further, the process includes the following steps: S1: Volatile oil extraction: Weigh the frankincense, myrrh, angelica, and chuanxiong from the yang-type medicinal components according to the prescription amount, crush them into coarse powder, add 5-7 times the amount of purified water and soak for 0.5-2 hours, extract the volatile oil using steam distillation for 3-6 hours, collect the volatile oil, seal and refrigerate for later use; S2: Water extraction and alcohol precipitation: Mix the residue after volatile oil extraction in step S1 with the yin-type medicinal components: sparganium, turmeric, honeysuckle vine, and loofah sponge. Add 8-12 times the amount of purified water and decoct 2-3 times, 1-2 hours each time. Combine the decoctions, filter, and concentrate the filtrate to a clear extract with a relative density of 1.05-1.15. After cooling, add ethanol to make the alcohol content 50%-70%, stir evenly, and let stand for 12-24 hours. Take the supernatant, recover the ethanol, and concentrate to a thick extract with a relative density of 1.20-1.30. S3: Cyclodextrin inclusion: Dilute the volatile oil collected in step S1 with anhydrous ethanol. S1: Slowly add the β-cyclodextrin to a saturated aqueous solution, with a β-cyclodextrin to volatile oil weight ratio of 4-8:1. Stir and incorporate at 30-50℃ for 1-3 hours, refrigerate and stand for 12-24 hours, filter, and dry the precipitate at low temperature to obtain the volatile oil inclusion complex; S2: Matrix preparation: Weigh the corresponding matrix raw materials according to the dosage form requirements, heat and melt or swell, stir evenly to obtain the matrix; S3: Mixing and homogenizing: Add the thick paste obtained in step S2, the volatile oil inclusion complex obtained in step S3, and camphor to the matrix obtained in step S4, stir evenly at 50-70℃, and then homogenize at a speed of 8000-15000 rpm for 5-15 minutes; S4: Filling and sterilization: Cool the homogenized preparation to room temperature, fill quantitatively into light-proof sealed packaging containers, and sterilize by cobalt-60 irradiation or flowing steam to obtain the finished product.

[0013] Furthermore, the application of the aforementioned transdermal topical preparation for promoting qi circulation in the preparation of non-therapeutic health conditioning products, wherein the health conditioning products are used in conjunction with massage therapy techniques.

[0014] Compared with the prior art, the present invention has the following beneficial effects: (i) This invention is based on the theory of Yin-Yang integration in traditional Chinese medicine. It combines the pungent and aromatic properties of Yang herbs, which penetrate the skin and promote Qi circulation, with the bitter and cold properties of Yin herbs, which promote blood circulation and dissipate nodules. This reflects the principle of Yin-Yang pairing and mutual assistance, and is more comprehensive and balanced than the single-effect formulas in the existing technology. (ii) The present invention is designed for massage therapy operations. By optimizing the rheological properties, it makes it have the characteristics of a pseudoplastic fluid with shear thinning, which perfectly matches the mechanical requirements of massage techniques. It not only ensures good lubricity and operation feel, but also promotes drug release and transdermal absorption, thereby achieving synergistic effect between drugs and techniques. (III) The present invention adopts an integrated preparation process of stepwise extraction, cyclodextrin inclusion and emulsification homogenization, which can retain the effective ingredients to the maximum extent, improve the stability and bioavailability of the preparation, and effectively solve the problems of easy loss of volatile oil and poor stability of traditional Chinese medicine external preparations; (iv) The product of this invention is positioned as a non-therapeutic health care product, which can be widely used in health centers, beauty salons, massage parlors and other places, and can also be used as a family health care product. It has a broad market space and good economic and social benefits. Detailed Implementation

[0015] To make the objectives, technical solutions, and technical effects of this invention clearer, specific embodiments of this invention are described below. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0016] This embodiment provides a transdermal topical preparation adapted for massage therapy, its preparation method, and its application. It is made from the following raw materials: frankincense, myrrh, camphor, angelica sinensis, chuanxiong rhizome, sparganium rhizome, turmeric rhizome, honeysuckle vine, loofah sponge, transdermal penetration enhancer, and excipients. Specific effects are as follows: Frankincense: It is pungent and warm, promotes blood circulation and qi, reduces swelling and relieves pain. It is a classic qi and blood pairing medicine with myrrh. It has clear anti-inflammatory, analgesic and local blood perfusion improvement effects, and can relieve aseptic inflammation of muscle fascia. Myrrh: bitter and pungent, it promotes blood circulation, removes blood stasis, reduces swelling and relieves pain. When combined with frankincense, it can regulate qi and blood. It can inhibit the release of inflammatory factors, improve local blood stasis, and loosen tissue adhesions caused by chronic strain. Camphor: It is pungent, hot and aromatic, and can open the orifices, relieve stagnation of qi, reduce swelling and relieve pain. It is the most effective natural permeation enhancer in the whole formula. As a skin irritant, it can reverse the lipid arrangement of the stratum corneum and significantly improve the drug transdermal rate. At the same time, it can dilate local microvessels and improve microcirculation. Angelica sinensis: It nourishes blood, promotes blood circulation, clears the meridians and relieves pain. It has the dual benefits of promoting blood circulation and protecting the body's vital energy. It can improve microcirculation, resist oxidation and promote skin tissue repair. It has the dual value of conditioning and skin care. Chuanxiong: It invigorates blood circulation, dispels wind and relieves pain. It is good at traversing the meridians and regulating the blood and qi of the whole body. It has the effects of dilating blood vessels, inhibiting platelet aggregation, relieving smooth muscle spasm, and significantly improving local blood flow. Sparganium rhizome: It breaks up blood stasis, promotes qi circulation, eliminates stagnation and relieves pain. Together with Curcuma zedoaria, it forms a classic pair of drugs for breaking up blood stasis and dispersing nodules. It has the effects of anti-thrombosis, improving microcirculation, and anti-tissue fibrosis, and promotes the loosening and absorption of soft tissues with chronic hyperplasia and adhesion. Curcuma zedoaria: It breaks up blood stasis, promotes qi circulation, eliminates stagnation and relieves pain. When combined with Sparganium stoloniferum, it achieves the dual effect of breaking up blood stasis and qi stasis. It has anti-inflammatory, analgesic, and local proliferative tissue absorption effects. It also improves aseptic inflammation and tissue adhesion. Honeysuckle vine: Clears heat and detoxifies, dispels wind and unblocks meridians. It is a vine-type medicine for unblocking meridians. It is cold in nature and clears away heat. It has anti-inflammatory, antibacterial, antipyretic, and inhibitory effects on local inflammatory response. It also has a certain immunomodulatory effect. Loofah sponge: dispels wind and unblocks meridians, invigorates blood and removes dampness. It has a mild medicinal property and is good at unblocking the meridians throughout the body. It has anti-inflammatory, analgesic, and antioxidant effects, and gently improves local microcirculation without irritation. Transdermal absorption enhancer: It is an enhancer of drug transdermal absorption. Together with the natural permeation enhancer of Chinese herbal volatile oil, it forms a dual permeation enhancer system, allowing drug components to reach the deep meridian and muscle lesion layer more quickly. Excipients: Aromatic scents can soothe emotions and relax the mind and body, creating a sensory synergy with the effects of the medicine in promoting qi circulation and unblocking meridians. Example

[0017] The raw materials are as follows by weight: Yang-type components: frankincense 10-25 parts, myrrh 10-25 parts, camphor 3-10 parts, angelica 15-30 parts, chuanxiong 15-30 parts; Yin-type components: sparganium 10-25 parts, turmeric 10-25 parts, honeysuckle vine 20-40 parts, loofah sponge 15-35 parts; massage oil base and herbal fragrance; wherein, the weight ratio of the Yang-type components to the Yin-type components is 1:0.8-1.2; the massage oil base, by weight percentage, contains: modified coconut oil 40-60%, olive oil 20-35%, vitamin E acetate 1-5%, glyceryl monostearate 2-8%, beeswax 2-6%, and the remainder is the active pharmaceutical ingredient; S1: Volatile oil extraction: Weigh the frankincense, myrrh, angelica, and chuanxiong from the yang-natured herbal components according to the prescription, crush them into coarse powder, add 5 times the amount of purified water and soak for 0.5 hours. Extract the volatile oil using steam distillation for 3 hours. Collect the volatile oil, seal and refrigerate for later use. When extracting the volatile oil using steam distillation, a segmented collection method is adopted. The initial distillate collected in the first 30 minutes is stored separately, and the subsequent fractions are combined to form the volatile oil product. The initial distillate is then distilled a second time to recover the volatile oil components. Segmented collection can improve the purity of the volatile oil and reduce the contamination of low-boiling-point impurities. S2: Water extraction and alcohol precipitation: The residue after extracting the volatile oil in step S1 is mixed with the Yin-nourishing components Sparganium rhizome, Curcuma rhizome, Lonicera japonica vine, and Luffa sponge. Eight times the amount of purified water is added and the mixture is decocted twice, 1 hour each time. The decoctions are combined and filtered through a 200-mesh filter cloth. The filtrate is concentrated to a clear paste with a relative density of 1.05. After cooling, ethanol is added to make the alcohol content reach 50%. The mixture is stirred evenly and allowed to stand for 12 hours. The supernatant is taken to recover the ethanol and concentrated to a thick paste with a relative density of 1.20. S3: Cyclodextrin inclusion complex: The volatile oil collected in step S1 is diluted with anhydrous ethanol and slowly added dropwise to a saturated aqueous solution of β-cyclodextrin. The weight ratio of β-cyclodextrin to volatile oil is 4-8:1. The mixture is stirred and included at 30°C for 1 hour, then refrigerated and allowed to stand for 12 hours. After filtration, the precipitate is dried at low temperature to obtain the volatile oil inclusion complex. The β-cyclodextrin solution is prepared by weighing β-cyclodextrin according to the ratio, adding 10 times the amount of purified water, heating to 60°C and stirring until completely dissolved, and then cooling to 30-50°C to obtain a saturated aqueous solution of β-cyclodextrin. S4: Matrix preparation: According to the dosage form requirements, weigh the corresponding massage oil matrix according to the prescription amount, place it in the oil phase pot, heat to 75℃, stir until completely melted, and keep warm for later use; S5: Homogenization: The thick paste obtained in step S2, the volatile oil inclusion complex obtained in step S3, and camphor are added to the oil phase matrix obtained in step S4. Then, grass fragrance is added, and the mixture is stirred evenly at 50°C. Homogenization is then performed at 8000 rpm for 5 minutes. A high-pressure homogenizer is used in this step, with a homogenization pressure of 20 MPa, and the homogenization is repeated twice. The average particle size of the homogenized formulation is 100 nm. High-pressure homogenization can obtain finer particle sizes and a more uniform dispersion system, further improving the stability and transdermal efficiency of the formulation. S6: Filling and Sterilization: After homogenization, the preparation is cooled to room temperature and quantitatively filled into light-proof and sealed packaging containers. It is then sterilized by cobalt-60 irradiation or by flowing steam to obtain the finished product of the massage oil-type transdermal topical preparation.

[0018] Quality inspection results: Appearance: Brownish-yellow transparent oily liquid with a distinctive Chinese herbal aroma; pH value (25℃): 6.8; Viscosity (25℃): 3200; Viscosity (25℃): 380; Particle size: No obvious particles were observed under a microscope; the particle size was uniform and fine. Stability: After accelerated testing (40℃, 75% relative humidity, 6 months), there were no significant changes in appearance, color, or aroma, and no layering or sedimentation. Microbial limits: Meets the requirements of the microbial limit standard for topical preparations. Example

[0019] The raw materials are as follows by weight: Yang-type components: frankincense 15-20 parts, myrrh 15-20 parts, camphor 5-8 parts, angelica 20-25 parts, chuanxiong 20-25 parts; Yin-type components: sparganium 15-20 parts, turmeric 15-20 parts, honeysuckle vine 25-35 parts, loofah sponge 20-30 parts; cream base, azone, propylene glycol and rose fragrance; wherein, the weight ratio of the Yang-type components to the Yin-type components is 1:0.8-1.2; the cream base, by weight percentage, contains: stearic acid 5-15%, glyceryl monostearate 2-8%, white petrolatum 5-15%, lanolin 2-6%, glycerin 5-15%, triethanolamine 0.5-2%, purified water 30-50%, and the remainder being active pharmaceutical ingredients; S1: Volatile oil extraction: Weigh the frankincense, myrrh, angelica, and chuanxiong from the yang-natured herbal components according to the prescription, crush them into coarse powder, add 7 times the amount of purified water and soak for 2 hours. Extract the volatile oil using steam distillation for 6 hours. Collect the volatile oil, seal and refrigerate for later use. When extracting the volatile oil using steam distillation, a segmented collection method is adopted. The initial distillate collected in the first 30 minutes is stored separately, and the subsequent fractions are combined to form the volatile oil product. The initial distillate is then distilled a second time to recover the volatile oil components. Segmented collection can improve the purity of the volatile oil and reduce the contamination of low-boiling-point impurities. S2: Water extraction and alcohol precipitation: The residue after extracting the volatile oil in step S1 is mixed with the Yin-nourishing components, including Sparganium rhizome, Curcuma rhizome, Lonicera japonica vine, and Luffa sponge. 12 times the amount of purified water is added and the mixture is decocted and extracted 3 times, 2 hours each time. The decoctions are combined and filtered through a 400-mesh filter cloth. The filtrate is concentrated to a clear paste with a relative density of 1.15. After cooling, ethanol is added to make the alcohol content reach 70%. The mixture is stirred evenly and allowed to stand for 24 hours. The supernatant is taken to recover the ethanol and concentrated to a thick paste with a relative density of 1.30. S3: Cyclodextrin inclusion complex: The volatile oil collected in step S1 is diluted with anhydrous ethanol and slowly added dropwise to a saturated aqueous solution of β-cyclodextrin. The weight ratio of β-cyclodextrin to volatile oil is 4-8:1. The mixture is stirred and included at 50°C for 3 hours, then refrigerated and allowed to stand for 24 hours. After filtration, the precipitate is dried at low temperature to obtain the volatile oil inclusion complex. The β-cyclodextrin solution is prepared by weighing β-cyclodextrin according to the ratio, adding 20 times the amount of purified water, heating to 80°C and stirring until completely dissolved, and then cooling to 50°C to obtain a saturated aqueous solution of β-cyclodextrin. S4: Matrix preparation: According to the dosage form requirements, weigh the corresponding amount of oil phase preparation according to the prescription: ointment matrix, place it in the oil phase pot, heat to 80℃, stir until completely melted, and keep warm for later use; aqueous phase preparation: weigh glycerin, triethanolamine, and propylene glycol, add them to purified water, heat to 80℃, stir evenly, and keep warm for later use. S5: Homogenization: The thick paste obtained in step S2, the volatile oil inclusion complex obtained in step S3, camphor, azone, and camphor are added to the matrix obtained in step S4. Then, rose fragrance is added, and the mixture is stirred evenly at 70°C. Homogenization is then performed at a speed of 15000 rpm for 15 minutes. A high-pressure homogenizer is used in this step, with a homogenization pressure of 50 MPa, and the homogenization is repeated 3 times. The average particle size of the homogenized formulation is 500 nm. High-pressure homogenization can obtain finer particle sizes and a more uniform dispersion system, further improving the stability and transdermal efficiency of the formulation. S6: Filling and Sterilization: After homogenization, the preparation is cooled to room temperature and quantitatively filled into light-proof and sealed packaging containers. It is then sterilized by cobalt-60 irradiation or by flowing steam to obtain the finished product of the massage oil-type transdermal topical preparation.

[0020] Quality inspection results: Appearance: Milky white to pale yellow cream with a delicate texture and a herbal aroma; pH value (25℃): 7.2; Viscosity (25℃): 2800; Viscosity (25℃): 2100; Particle size: No obvious particles were observed under a microscope; the average particle size was approximately 250 nm. Stability: After accelerated testing (40℃, 75% relative humidity, 6 months), there were no significant changes in appearance, color, or aroma, and no layering or emulsion breaking occurred. Microbial limits: Meets the requirements of the microbial limit standard for topical preparations. Example

[0021] The raw materials are as follows by weight: Yang-type components: frankincense 18 parts, myrrh 17 parts, camphor 7 parts, angelica 22 parts, chuanxiong 23 parts; Yin-type components: sparganium 17 parts, turmeric 18 parts, honeysuckle vine 30 parts, loofah sponge 25 parts; gelling agent base, menthol, β-caryophyllene and herbal fragrance; wherein, the weight ratio of the Yang-type components to the Yin-type components is 1:0.8-1.2; the gelling agent matrix, by weight percentage, contains: carbomer 940 0.5-2%, glycerin 5-15%, triethanolamine 0.5-2%, ethanol 5-15%, purified water 50-70%, and the remainder is the active pharmaceutical ingredient; S1: Volatile oil extraction: Weigh the frankincense, myrrh, angelica, and chuanxiong from the yang-natured herbal components according to the prescription, crush them into coarse powder, add 6 times the amount of purified water and soak for 1 hour. Extract the volatile oil using steam distillation for 4 hours. Collect the volatile oil, seal and refrigerate for later use. When extracting the volatile oil using steam distillation, a segmented collection method is adopted. The initial distillate collected in the first 30 minutes is stored separately, and the subsequent fractions are combined to form the volatile oil product. The initial distillate is then distilled a second time to recover the volatile oil components. Segmented collection can improve the purity of the volatile oil and reduce the contamination of low-boiling-point impurities. S2: Water extraction and alcohol precipitation: The residue after extracting the volatile oil in step S1 is mixed with the Yin-nourishing components Sparganium rhizome, Curcuma rhizome, Lonicera japonica vine, and Luffa sponge. 10 times the amount of purified water is added and the mixture is decocted twice for 1.5 hours each time. The decoctions are combined and filtered through a 300-mesh filter cloth. The filtrate is concentrated to a clear paste with a relative density of 1.10. After cooling, ethanol is added to make the alcohol content reach 60%. The mixture is stirred evenly and allowed to stand for 20 hours. The supernatant is taken to recover the ethanol and concentrated to a thick paste with a relative density of 1.25. S3: Cyclodextrin inclusion complex: The volatile oil collected in step S1 is diluted with anhydrous ethanol and slowly added dropwise to a saturated aqueous solution of β-cyclodextrin. The weight ratio of β-cyclodextrin to volatile oil is 4-8:1. The mixture is stirred and included at 45°C for 2 hours, then refrigerated and allowed to stand for 20 hours. After filtration, the precipitate is dried at low temperature to obtain the volatile oil inclusion complex. The β-cyclodextrin solution is prepared by weighing β-cyclodextrin according to the proportion, adding 15 times the amount of purified water, heating to 70°C and stirring until completely dissolved, and then cooling to 40°C to obtain a saturated aqueous solution of β-cyclodextrin. S4: Matrix preparation: Weigh Carbomer 940, sprinkle it into an appropriate amount of purified water, and let it swell for 24 hours to prepare a carbomer gel. Separately, take glycerol and triethanolamine, add them to the remaining purified water, stir well, and then slowly add them to the carbomer gel while stirring. Adjust the pH value to 6.5-7.0 to obtain a transparent gel matrix; S5: Homogenization: The viscous paste obtained in step S2 is dissolved in ethanol and added to the gel matrix. The mixture is stirred until homogeneous. The volatile oil inclusion complex, camphor, β-caryophyllene, and menthol obtained in step S3 are then added to the matrix obtained in step S4. Next, the herbal fragrance is added, and the mixture is stirred until homogeneous at 60°C. Homogenization is then performed at 12000 rpm for 10 minutes. A high-pressure homogenizer is used in this step, with a homogenization pressure of 35 MPa, and the homogenization is repeated twice. The average particle size of the homogenized formulation is 400 nm. High-pressure homogenization can achieve finer particle size and a more uniform dispersion system, further improving the stability and transdermal efficiency of the formulation. S6: Filling and Sterilization: Cool the homogenized gel to room temperature and fill it quantitatively into light-proof plastic tubes. After sterilization by cobalt-60 irradiation or by circulating steam sterilization, the finished product of the massage oil formulation for transdermal application is obtained.

[0022] Quality inspection results: Appearance: Pale yellow transparent gel with a refreshing texture and a cool herbal aroma; pH value (25℃): 6.7; Viscosity (25℃): 8500; Viscosity (25℃): 620; Particle size: No obvious particles were observed under a microscope; the particle size was uniform and fine. Stability: After accelerated testing (40℃, 75% relative humidity, 6 months), there were no significant changes in appearance, color, or transparency, and no stratification or water separation. Microbial limits: Meets the requirements of the microbial limit standard for topical preparations.

[0023] application: The application of the aforementioned transdermal topical preparation for promoting Qi circulation in the preparation of non-therapeutic health conditioning products, wherein the health conditioning products are used in conjunction with massage techniques to achieve the health benefits of unblocking meridians, promoting Qi and blood circulation, relieving muscle fatigue, improving local microcirculation, and regulating the body's Yin-Yang balance; the specific steps are as follows: T1: Preliminary preparation: Select the appropriate body position according to the area to be treated, and evenly apply the Qi-regulating transdermal topical preparation for massage therapy to the skin area centered on the treatment target point. Use a preheating method to promote the initial penetration of the drug. T2: Guiding Qi along the meridians: Using pushing, rubbing and kneading techniques along the meridian pathways to regulate the flow of Qi and transmit the effects of the medication to the entire meridian; T3: Target Release: Using a unique finger-needle technique, vertically press and pluck the target points of the meridian lesions, directing the synergistic effect of the medication and the technique to the deep lesions. T4: Finishing touch-up: Using meridian rubbing techniques and local relaxation techniques to harmonize the flow of Qi and blood in the meridians and consolidate the conditioning effect.

[0024] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A transdermal topical preparation suitable for massage therapy, characterized in that: It is made from the following raw materials: Yang medicine component: 10-25 parts frankincense, 10-25 parts myrrh, 3-10 parts camphor, 15-30 parts angelica, 15-30 parts chuanxiong; Yin medicine component: 10-25 parts sparganium, 10-25 parts turmeric, 20-40 parts honeysuckle vine, 15-35 parts loofah sponge; wherein, the weight ratio of the Yang medicine component to the Yin medicine component is 1:0.8-1.

2.

2. The topical preparation for promoting Qi circulation and regulating Qi, as described in claim 1, is characterized in that: The raw materials are in the following weight proportions: Yang-type components: frankincense 15-20 parts, myrrh 15-20 parts, camphor 5-8 parts, angelica 20-25 parts, chuanxiong 20-25 parts; Yin-type components: sparganium 15-20 parts, turmeric 15-20 parts, honeysuckle vine 25-35 parts, loofah sponge 20-30 parts.

3. The topical preparation for promoting Qi circulation and regulating Qi, as described in claim 2, is characterized in that: The raw materials are in the following weight proportions: Yang-type components: frankincense 18 parts, myrrh 17 parts, camphor 7 parts, angelica 22 parts, chuanxiong 23 parts; Yin-type components: sparganium 17 parts, turmeric 18 parts, honeysuckle vine 30 parts, loofah sponge 25 parts.

4. The topical preparation for promoting Qi circulation and regulating Qi, as described in claim 1, is characterized in that: It also includes a topical matrix, which is any one of a massage oil matrix, a cream matrix, or a gel matrix.

5. The transdermal topical preparation for massage therapy according to claim 1 or 4, characterized in that: It also includes transdermal penetration enhancers and excipients, wherein the transdermal penetration enhancer is one or more combinations of azone, propylene glycol, menthol, borneol, and β-caryophyllene; the weight of the transdermal penetration enhancer accounts for 0.5% to 5% of the total weight of the formulation; and the excipient is one of grass flavoring or rose flavoring.

6. A method for preparing a transdermal topical preparation adapted for massage therapy as described in any one of claims 1-5, characterized in that, Includes the following steps: S1: Volatile oil extraction: Weigh the frankincense, myrrh, angelica, and chuanxiong from the yang-type herb components according to the prescription, crush them into coarse powder, add 5-7 times the amount of purified water and soak for 0.5-2 hours, extract the volatile oil by steam distillation for 3-6 hours, collect the volatile oil, seal and refrigerate for later use. S2: Water extraction and alcohol precipitation: The residue after extracting the volatile oil in step S1 is mixed with the Yin-nourishing components, including Sparganium rhizome, Curcuma rhizome, Lonicera japonica vine, and Luffa sponge. 8-12 times the amount of purified water is added and the mixture is decocted and extracted 2-3 times, 1-2 hours each time. The decoctions are combined, filtered, and the filtrate is concentrated to a clear paste with a relative density of 1.05-1.

15. After cooling, ethanol is added to make the alcohol content reach 50%-70%. The mixture is stirred evenly and allowed to stand for 12-24 hours. The supernatant is taken to recover the ethanol and concentrated to a thick paste with a relative density of 1.20-1.

30. S3: Cyclodextrin inclusion complex: The volatile oil collected in step S1 is diluted with anhydrous ethanol and slowly added dropwise to a saturated aqueous solution of β-cyclodextrin. The weight ratio of β-cyclodextrin to volatile oil is 4-8:

1. The mixture is stirred and included at 30-50°C for 1-3 hours, then refrigerated and allowed to stand for 12-24 hours. The mixture is then filtered, and the precipitate is dried at low temperature to obtain the volatile oil inclusion complex. S4: Matrix preparation: According to the dosage form requirements, weigh the corresponding matrix raw materials according to the prescription amount, heat and melt or swell, stir evenly, and obtain the matrix; S5: Mixing and homogenizing: Add the thick paste obtained in step S2, the volatile oil inclusion complex obtained in step S3, and camphor to the matrix obtained in step S4, stir evenly at 50-70°C, and then perform homogenization treatment at a speed of 8000-15000 rpm for 5-15 min. S6: Filling and Sterilization: After homogenization, the preparation is cooled to room temperature, quantitatively filled into light-proof and sealed packaging containers, and sterilized by cobalt-60 irradiation or flowing steam to obtain the finished product.

7. The use of the transdermal topical preparation according to any one of claims 1-5 in the preparation of a non-therapeutic health care product, characterized in that, The health care products are used in conjunction with massage therapy techniques.

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