A daoye composition and application thereof in preparation of external preparation for treating abdominal pain (dietary accumulation stagnation syndrome)

Abstract

The application discloses a Dai medicine composition and application thereof in preparation of external preparation for treating abdominal pain (dietary accumulation and stagnation syndrome), and belongs to the technical field of national medicine. The composition is composed of hao-ming (turmeric), he-gu (amomum xanthioides), he-ga (amomum xanthioides), fried wheat germ, atractylodes, dried ginger, amomum villosum, dried tangerine or orange peel and gizzard-bladder, and the components are proportioned according to specific weight parts. The above-mentioned Dai medicine and traditional Chinese medicine are matched, water is added to decoct, and then the mixture is put into eggs to be cooked together, the warm medicine eggs are rolled along the meridians and acupoints of the abdomen to perform external treatment, and the synergistic effect of heat, medicine efficacy and acupoint stimulation is exerted. According to three groups of parallel random control clinical test verifications, the composition has a significant curative effect on abdominal pain (dietary accumulation and stagnation syndrome), the total effective rate is greater than or equal to 85%, is better than that of simple white egg rolling method and Dai medicine permeation therapy, and has no gastrointestinal stimulation and skin adverse reactions, is suitable for patients of all ages, and is suitable for popularization and use in primary medical institutions.

Description

Technical Field

[0001] The present invention belongs to the technical field of ethnic medicine, and specifically relates to a Dai medicine composition and the application thereof in preparing an external preparation for treating abdominal pain (food accumulation syndrome). Background Art

[0002] Abdominal pain (food accumulation syndrome) is a common clinical digestive system disease that can occur in all age groups including children, adults and the elderly. In modern medicine, oral digestive-promoting, antispasmodic and analgesic drugs are mostly used for treatment, but there are drawbacks such as poor medication compliance and gastrointestinal irritation. Traditional Chinese medicine mainly uses oral decoctions for invigorating the spleen and resolving accumulation, long-term administration may easily damage the healthy qi of the spleen and stomach, children refuse to take the medicine due to its bitter taste, and elderly patients cannot tolerate long-term medication. Therefore, there is an urgent clinical need for a safe, effective, non-invasive external treatment technology with high acceptance across all populations.

[0003] Egg-rolling therapy originated from Miao medicine and has been widely inherited and applied in the medicine of ethnic minorities such as Zhuang, Yao, Qiang and Yi. Its principle is to use warm boiled eggs to roll and stimulate meridians and acupoints on the body surface, so as to dredge qi and blood, promote digestion and resolve stagnation. Existing documents only report pure egg or common traditional Chinese medicine egg-rolling therapy, and there is no research report on the external treatment of abdominal pain (food accumulation syndrome) by using eggs boiled with the characteristic Dai medicine from Dehong combined with spleen-invigorating and accumulation-resolving traditional Chinese medicines.

[0004] Dai medicine is a characteristic biomedicine resource in Dehong Prefecture. The Dai medicine theory takes "four towers and five aggregates" as the core, and the regulation of the spleen and stomach falls into the category of "earth tower" disease treatment. Dai medicine Haoming (turmeric) has the effects of activating blood and moving qi, relieving pain and dissipating blood stasis; Hegu (Amomum maximum root) and Hega (Dai Alpinia galanga root) are pungent in taste and hot in nature, act on the earth, wind and fire towers, and are specially effective in strengthening the stomach and tonifying the earth, regulating qi and resolving accumulation. Integrating the above Dai medicines with spleen-invigorating and accumulation-resolving traditional Chinese medicines and carrying out external treatment through the egg-rolling method is expected to avoid the drawbacks of oral drugs and give full play to the characteristic advantages of ethnic medicine. Summary of the Invention

[0005] (1) Purpose of the Invention The present invention provides a Dai medicine composition and a medicinal egg preparation thereof for treating abdominal pain (food accumulation syndrome), so as to solve the technical problems of poor compliance of existing oral drug treatment, obvious gastrointestinal irritation, and inapplicability to patients of all age groups. The present invention also provides the preparation method and use of the composition.

[0006] (2) Technical Solution To achieve the above purpose, the present invention provides the following technical solutions: A Dai medicine composition for treating abdominal pain (food accumulation syndrome), which is composed of the following raw medicinal materials in parts by weight: 10-20 parts of Haoming (turmeric), 10-20 parts of Hegu (Amomum maximum root), 10-20 parts of Hega (Dai Alpinia galanga root), 8-16 parts of roasted malt, 6-14 parts of rhizoma atractylodis, 6-14 parts of dried ginger, 4-10 parts of fructus amomi, 8-16 parts of pericarpium citri reticulatae, and 8-16 parts of endothelium corneum gigeriae galli.

[0007] Preferably, the raw materials are composed of the following parts by weight: 16 parts of malt, 16 parts of licorice root, 16 parts of licorice root, 12 parts of roasted malt, 10 parts of atractylodes rhizome, 10 parts of dried ginger, 6 parts of amomum villosum, 12 parts of dried tangerine peel, and 12 parts of chicken gizzard lining.

[0008] The present invention also provides a medicinal egg prepared by boiling the aforementioned Dai medicine composition, which is used for external treatment by rolling on abdominal acupoints.

[0009] The present invention also provides the use of the Dai medicine composition in the preparation of a topical preparation for treating abdominal pain (food stagnation syndrome).

[0010] (III) Beneficial Effects This invention is the first to combine Dai medicinal herbs such as Haoming, Hegu, and Hega with spleen-strengthening and digestion-eliminating Chinese herbs (fried malt, Atractylodes lancea, dried ginger, Amomum villosum, tangerine peel, and chicken gizzard lining) to form a brand-new ethnic medicine-integrated external treatment compound, specifically for abdominal pain (food stagnation syndrome), filling a technological gap in this field.

[0011] This invention administers medication via an egg-boiling method, without oral administration, causing no gastrointestinal irritation or adverse skin reactions. It is safe, gentle, and suitable for patients of all ages.

[0012] This invention fully utilizes the synergistic effect of heat, Dai medicine efficacy, and acupoint rolling technique, and is expected to have a significantly better therapeutic effect than simple egg rolling method and simple Dai medicine transdermal therapy.

[0013] This invention is simple to operate, requires low equipment investment, and uses inexpensive and readily available consumables, making it suitable for promotion and application in primary healthcare institutions such as township health centers and community health service centers. Detailed Implementation

[0014] The present invention will be further described in detail below with reference to embodiments, but the implementation of the present invention is not limited thereto.

[0015] Example 1 (Preferred Formula) Take 160g of *Houttuynia cordata*, 160g of *Hegu*, 160g of *Hega*, 120g of roasted malt, 100g of *Atractylodes lancea*, 100g of dried ginger, 60g of *Amomum villosum*, 120g of dried tangerine peel, and 120g of chicken gizzard lining. Remove impurities, grind into powder, and pass through a 20-mesh sieve. Place the powder in a non-woven bag. Put the bag into a stainless steel egg cooker, add 6 liters of water, and soak for 30 minutes. Bring to a boil over high heat, then simmer over low heat for 30 minutes. Gently place 30 fresh, room-temperature eggs into the liquid, maintaining a gentle simmer for 15 minutes. Turn off the heat, cover, and let it steep for 60 minutes. Remove the eggs, but do not remove the powdered bag. Add 4 liters of water again, bring to a boil, and simmer over low heat for 20 minutes. Return the eggs to the pot, turn off the heat, and let it steep for 30 minutes. Place the eggs and liquid in a constant temperature incubator at 50-60 degrees Celsius to keep warm. Use as needed, maintaining the surface temperature of the eggs at 45-50 degrees Celsius.

[0016] Example 2 (Lower limit of the mixing ratio range) Take 100g of *Houttuynia cordata*, 100g of *Hegu*, 100g of *Hega*, 80g of roasted malt, 60g of *Atractylodes lancea*, 60g of dried ginger, 40g of *Amomum villosum*, 80g of dried tangerine peel, and 80g of chicken gizzard lining, and prepare them according to the method described in Example 1. Adjust the amount of water added accordingly to 5 liters, and the cooking time and simmering time are the same as in Example 1.

[0017] Example 3 (Upper Limit of Proportion Range) Take 200g of *Houttuynia cordata*, 200g of *Hegu*, 200g of *Hega*, 160g of roasted malt, 140g of *Atractylodes lancea*, 140g of dried ginger, 100g of *Amomum villosum*, 160g of dried tangerine peel, and 160g of chicken gizzard lining, and prepare them according to the method described in Example 1. Adjust the amount of water added accordingly to 8 liters, and the cooking time and simmering time are the same as in Example 1.

[0018] Comparative example (white egg rolling method) Take fresh eggs, boil them in water at room temperature, simmer for 15 minutes after boiling, turn off the heat and let them sit for 10 minutes, then keep them warm at 45 to 50 degrees Celsius for later use.

[0019] Clinical application examples Trial Design: A randomized, parallel controlled clinical trial design was adopted, which included 90 patients who met the diagnostic criteria for abdominal pain (food stagnation syndrome) and randomly divided them into experimental group, control group 1, and control group 2, with 30 patients in each group.

[0020] Experimental Groups: Experimental group: The medicinal egg prepared in Example 1 was used. It was rolled gently clockwise along the Ren meridian and the Stomach meridian of Foot Yangming in the abdomen, focusing on acupoints such as Zhongwan, Tianshu, and Qihai. Each operation lasted 15 to 20 minutes, and the treatment was performed once every 3 days for a total of 3 treatments.

[0021] Control group 1: White eggs prepared using the control example, with the same operation method as the experimental group.

[0022] Control group 2: Targeted transdermal drug delivery therapy using Dai medicine compound.

[0023] Therapeutic efficacy evaluation indicators: Traditional Chinese Medicine Syndrome Score: Comparison of individual scores for abdominal distension, abdominal pain, belching, appetite, and bowel movements before and after treatment.

[0024] Clinical overall effectiveness rate: divided into four levels: cured, significantly effective, effective, and ineffective. The evaluation criteria are based on the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines (Trial)".

[0025] Safety indicators: Record local adverse reactions such as skin redness and itching throughout the process.

[0026] Expected therapeutic effect: The expected total clinical efficacy rate of the experimental group is over 85%, which is superior to that of control group 1 (simple white egg rolling method) and control group 2 (Dai medicine transdermal therapy), and the difference is expected to be statistically significant (P < 0.05). The expected improvement in TCM syndrome scores in the experimental group is higher than that in the two control groups. No serious adverse events such as skin burns or allergies are expected to occur throughout the course.

[0027] The above-mentioned solutions indicate that the Dai medicine composition and medicinal egg provided by the present invention have the expected significant clinical efficacy for abdominal pain (food stagnation syndrome), and have good safety, making them suitable for widespread application.

Claims

1. A Dai medicine composition for treating abdominal pain (food stagnation syndrome), characterized in that, It is composed of the following ingredients in parts by weight: 16 parts of turmeric, 16 parts of cardamom root, 16 parts of tsaoko root, 12 parts of roasted malt, 10 parts of atractylodes, 10 parts of dried ginger, 6 parts of amomum villosum, 12 parts of dried tangerine peel, and 12 parts of chicken gizzard lining.

2. The Dai medicine composition according to claim 1, characterized in that, The active pharmaceutical ingredient is coarse powder that has been pulverized through a 20-mesh sieve.

3. A medicinal egg prepared by boiling the Dai medicine composition according to claim 1.

4. The medicinal egg according to claim 3, characterized in that: The medicinal egg is obtained by boiling fresh eggs in an aqueous extract of the pharmaceutical composition of claim 1.

5. The use of the Dai medicine composition of claim 1 in the preparation of a topical preparation for treating abdominal pain (food stagnation syndrome).

6. The application according to claim 5, characterized in that, The external preparation is a medicinal egg obtained by boiling the aqueous extract of the Dai medicine composition according to claim 1.