Medical cloth special bacteriostatic environment-friendly detergent and its preparation process

Abstract

The application discloses a special bacteriostatic environment-friendly detergent for medical linen and a preparation process thereof, and belongs to the technical field of detergents. The beta-cyclodextrin is crosslinked with epichlorohydrin and porogenized by polyethylene glycol through alkali catalysis to obtain a beta-cyclodextrin porous polymer, and then the beta-cyclodextrin porous polymer is loaded with alkaline protease, lipase and cellulase after inclusion of essential oil, and is freeze-dried to obtain an enzyme-essential oil cyclodextrin composite powder; and then the enzyme-essential oil cyclodextrin composite powder is blended with a surfactant, a builder and deionized water to prepare the detergent. The host-guest inclusion and the pore confinement effect of the cavity and the mesoporous network of the cyclodextrin realize slow release of the essential oil and conformation protection of the enzyme activity, maintain the catalytic stability of the medical composite enzyme in the anionic surfactant system, provide the medical linen with the synergistic effect of persistent enzymatic decontamination and essential oil bacteriostasis, and realize the consideration of the decontamination capacity and the long-acting bacteriostasis.

Description

Technical Field

[0001] This invention belongs to the field of detergent technology, specifically an antibacterial and environmentally friendly detergent for medical linens and its formulation process. Background Technology

[0002] Medical linens are frequently touched items in medical institutions, and their cleanliness and antibacterial levels directly affect patient safety. Existing medical linen detergents typically use anionic surfactants as the main cleaning agent, combined with proteases, lipases, and other biological enzymes and plant essential oils to enhance the enzymatic removal of blood stains and lipid-based medical stains while reducing the risk of chemical antibacterial agent residue.

[0003] However, the above-mentioned compound system has significant defects: the anionic surfactant, enzyme preparation and plant essential oil coexist directly in the same liquid phase. The surfactant destroys the hydrophobic core of the enzyme protein, and the small molecules of essential oil are easily adsorbed on the active site of the enzyme or destroy its tertiary structure, resulting in rapid decay of enzyme activity. At the same time, the free essential oil is volatile and unevenly dispersed, making it difficult to achieve slow-release and long-lasting antibacterial effect. Moreover, the enzymatic cleaning and essential oil antibacterial effect lack an effective spatial isolation and synergistic release mechanism, making it difficult to exert the optimal efficacy at the same time. This results in a high residual stain rate and insufficient antibacterial effect after washing medical linens.

[0004] Therefore, how to construct a spatial isolation protection mechanism between enzyme preparations and hydrophobic antibacterial components, maintain the conformational stability of medical compound enzymes in anionic surfactant systems, and achieve synergistic effects between sustained-release of essential oils and enzyme-catalyzed stain removal has become a key technical problem that urgently needs to be solved in the field of medical linen detergents.

[0005] Allow The purpose of this invention is to provide a special antibacterial and environmentally friendly detergent for medical linens and its formulation process. By introducing β-cyclodextrin porous polymer as a bifunctional loading carrier in conjunction with medical compound enzymes and tea tree oil into a liquid detergent system, the host-guest inclusion and pore confinement effect of cyclodextrin cavity and mesoporous network are utilized to achieve sustained and controlled release of tea tree oil and spatial isolation protection of medical compound enzymes, thereby improving the detergency and antibacterial durability of medical linens after washing.

[0006] The objective of this invention can be achieved through the following technical solutions: This antibacterial and environmentally friendly detergent for medical linens, by weight, includes the following ingredients: 5-10 parts of enzyme-essential oil cyclodextrin composite powder; 15-30 parts of sodium fatty alcohol polyoxyethylene ether sulfate; Sodium citrate 2-8 parts; 1-3 parts of sorbitol; 40-80 parts deionized water; The above-mentioned enzyme-essential oil cyclodextrin composite powder is prepared by first encapsulating β-cyclodextrin with tea tree oil and then immobilizing it with a medical composite enzyme under alkaline conditions through polyethylene glycol pore formation and epichlorohydrin crosslinking to form a porous polymer.

[0007] Furthermore, the specific preparation process of the enzyme-essential oil cyclodextrin composite powder is as follows: The loaded essential oil cyclodextrin polymer powder and deionized water were placed in a reaction vessel and ultrasonically dispersed for 10-20 min. A phosphate buffer solution with a pH of 7.8 was added, and the mixture was stirred at 0-5℃ for 20-40 min. A medical compound enzyme aqueous solution was added, and the reaction was continued at the same temperature for 2-4 h. The mixture was centrifuged, the solid was collected, and freeze-dried to constant weight to obtain the enzyme-essential oil cyclodextrin composite powder.

[0008] The ratio of essential oil-loaded cyclodextrin polymer powder, deionized water, phosphate buffer solution, and medical compound enzyme aqueous solution is 40-60g: 200-400mL: 1.5-2L: 150-250mL.

[0009] The specific preparation process of the medical compound enzyme aqueous solution is as follows: Alkaline protease, alkaline lipase, and alkaline cellulase were mixed at an enzyme activity ratio of 3:2:1, and then added to a phosphate buffer solution with a pH of 7.8 to form a medical compound enzyme aqueous solution with a total protein concentration of 2-5 mg / mL.

[0010] Furthermore, the specific preparation process of the essential oil-loaded cyclodextrin polymer powder is as follows: Tea tree oil and ethanol were placed in a reaction vessel under a nitrogen atmosphere, deionized water was added, and the mixture was stirred and emulsified at 0-5℃ for 10-20 min. β-cyclodextrin porous polymer was added, and the mixture was reacted at 25-35℃ in the dark for 6-8 h. After centrifugation, the solid was collected, washed, and freeze-dried to constant weight to obtain oil-loaded cyclodextrin polymer powder.

[0011] The ratio of tea tree oil, ethanol, deionized water and β-cyclodextrin porous polymer is 6-8g: 80-120mL: 300-500mL: 40-60g.

[0012] Furthermore, the specific preparation process of the β-cyclodextrin porous polymer is as follows: β-Cyclodextrin and an 8wt% sodium hydroxide aqueous solution were placed in a reaction vessel and stirred at 25-35℃ for 0.5-1.5 h. Polyethylene glycol was added and stirred at the same temperature for 5-15 min. Epichlorohydrin was added and reacted at 50-60℃ with the same stirring rate for 3-5 h. The mixture was filtered, washed, extracted with anhydrous ethanol, vacuum dried to constant weight, ground and sieved to obtain a porous β-cyclodextrin polymer.

[0013] The ratio of β-cyclodextrin, sodium hydroxide aqueous solution, polyethylene glycol and epichlorohydrin is 90-110g: 350-450mL: 10-30g: 40-60mL.

[0014] This invention also provides a formulation process for a special antibacterial and environmentally friendly detergent for medical linens, comprising the following steps: Sodium citrate (chelating agent), sodium fatty alcohol polyoxyethylene ether sulfate (surfactant), and deionized water are placed in a reaction vessel and stirred at 40-50℃ for 40-60 minutes. The mixture is then cooled to 25-35℃, and sorbitol (enzyme stabilizer) and enzyme-essential oil cyclodextrin composite powder are added. The mixture is stirred at the same temperature for 20-30 minutes and allowed to stand to defoam, thus obtaining a special antibacterial and environmentally friendly detergent for medical linens.

[0015] The beneficial effects of this invention are: 1. The antibacterial and environmentally friendly detergent for medical linens prepared in this invention introduces an enzyme-essential oil cyclodextrin composite powder, giving the detergent both cleaning and antibacterial functions. The β-cyclodextrin porous polymer forms a stable three-dimensional framework after cross-linking and pore formation. First, the cyclodextrin cavity is used to encapsulate tea tree oil, reducing its evaporation loss during storage. Then, a medical-grade composite enzyme is immobilized on the mesoporous network and surface active sites, achieving spatial isolation between the essential oil and the enzyme on the same carrier. The tea tree oil is gradually released during washing, inhibiting microorganisms on the surface of the medical linens; the composite enzyme targets and decomposes protein, lipid, and fibrous stains. The synergistic effect of both enhances the cleaning effect of medical linens while ensuring the detergent's performance stability during storage and use.

[0016] 2. The antibacterial and environmentally friendly detergent for medical linens prepared in this invention utilizes tea tree oil, medical-grade compound enzymes, and a conventional washing aid system in synergistic action to achieve efficient cleaning of medical linens while ensuring hygiene and safety. Tea tree oil, as a natural antibacterial component, reduces the use of irritating chemical ingredients; the compound enzymes have a strong specific decomposition ability on stains, achieving efficient stain removal under relatively gentle conditions; sodium citrate and sodium fatty alcohol polyoxyethylene ether sulfate work together to further improve stain removal and dispersion capabilities. The synergistic effect of these components allows the detergent to meet the cleanliness and hygiene requirements of medical linens while helping to reduce the risk of chemical antibacterial agent residue, demonstrating promising application prospects. Detailed Implementation

[0017] The technical solutions of the present invention will be clearly and completely described below with reference to the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0018] Example 1: This example provides an antibacterial and environmentally friendly detergent specifically for medical linens, prepared through the following steps: S1: 90g of β-cyclodextrin and 350mL of 8wt% sodium hydroxide aqueous solution were placed in a reaction vessel and stirred at 200r / min for 0.5h at 25℃. 10g of polyethylene glycol was added and reacted at the same temperature and stirring rate for 5min. 40mL of epichlorohydrin was added and reacted at 50℃ at the same stirring rate for 3h. After the reaction was completed, the mixture was cooled to room temperature, filtered, and the solid was washed with deionized water until the last wash was neutral. The solid was transferred to a Soxhlet extractor and extracted with anhydrous ethanol for 22h. The solid was then vacuum dried at 50℃ to constant weight, ground, and sieved through a 100-mesh sieve to obtain a porous β-cyclodextrin polymer.

[0019] This step involves a ring-opening etherification reaction between the hydroxyl groups of β-cyclodextrin and the epoxy groups of epichlorohydrin under alkaline conditions, followed by a nucleophilic substitution reaction of chloromethyl groups to form ether crosslinks, thus constructing a three-dimensional network framework. Polyethylene glycol is dispersed in the polymerization system as a polymeric porogen. After being washed with water and removed by Soxhlet extraction with ethanol, mesoporous pores are left in the crosslinked network, resulting in a porous polymer of β-cyclodextrin.

[0020] S2: Place 6g of tea tree oil and 80mL of ethanol in a reaction vessel under nitrogen atmosphere protection, add 300mL of deionized water, and stir and emulsify at 1000r / min at 0℃ for 10min. Add 40g of β-cyclodextrin porous polymer, and react at 25℃ with the same stirring rate in the dark for 6h. After the reaction is completed, centrifuge and collect the solid. Wash the solid twice with deionized water and freeze-dry to constant weight to obtain oil-loaded cyclodextrin polymer powder.

[0021] S3: Alkaline protease, alkaline lipase, and alkaline cellulase were mixed at an enzyme activity ratio of 3:2:1, and then a phosphate buffer solution with a pH of 7.8 was added to form a medical compound enzyme aqueous solution with a total protein concentration of 2 mg / mL, which was set aside for later use. 40 g of essential oil cyclodextrin polymer powder and 200 mL of deionized water were placed in a reaction vessel and ultrasonically dispersed for 10 min. 1.5 L of phosphate buffer solution with a pH of 7.8 was added, and the mixture was stirred at 200 r / min for 20 min at 0 °C. 150 mL of the medical compound enzyme aqueous solution was added, and the reaction was continued for 2 h at the same temperature and stirring rate. After the reaction was completed, the solid was collected by centrifugation and freeze-dried to constant weight to obtain enzyme-essential oil cyclodextrin composite powder.

[0022] S4: Place 2g sodium citrate (chelating agent), 15g sodium fatty alcohol polyoxyethylene ether sulfate (surfactant) and 40g deionized water in a reaction vessel, stir at 200r / min for 40min at 40℃, cool to 25℃, add 1g sorbitol (enzyme stabilizer) and 5g enzyme-essential oil cyclodextrin composite powder, stir at 100r / min for 20min at the same temperature, let stand to defoam for 10min, and obtain a medical linen-specific antibacterial and environmentally friendly detergent.

[0023] Example 2: This example provides an antibacterial and environmentally friendly detergent specifically for medical linens, prepared through the following steps: S1: 100g of β-cyclodextrin and 400mL of 8wt% sodium hydroxide aqueous solution were placed in a reaction vessel and stirred at 250r / min for 1h at 30℃. 15g of polyethylene glycol was added and reacted at the same temperature and stirring rate for 10min. 50mL of epichlorohydrin was added and reacted at 55℃ at the same stirring rate for 4h. After the reaction was completed, the mixture was cooled to room temperature, filtered, and the solid was washed with deionized water until the last wash was neutral. The solid was transferred to a Soxhlet extractor and extracted with anhydrous ethanol for 23h. The solid was then vacuum dried at 55℃ to constant weight, ground, and sieved through a 150-mesh sieve to obtain a porous β-cyclodextrin polymer.

[0024] S2: Place 7g of tea tree essential oil and 100mL of ethanol in a reaction vessel under nitrogen atmosphere protection, add 400mL of deionized water, and stir and emulsify at 1500r / min at 3℃ for 15min. Add 50g of β-cyclodextrin porous polymer, and react at 30℃ with the same stirring rate in the dark for 7h. After the reaction is completed, centrifuge and collect the solid. Wash the solid with deionized water 3 times and freeze dry to constant weight to obtain essential oil-loaded cyclodextrin polymer powder.

[0025] S3: Alkaline protease, alkaline lipase, and alkaline cellulase were mixed at an enzyme activity ratio of 3:2:1, and then a phosphate buffer solution with a pH of 7.8 was added to form a medical compound enzyme aqueous solution with a total protein concentration of 3.5 mg / mL, which was set aside for later use. 50 g of essential oil cyclodextrin polymer powder and 300 mL of deionized water were placed in a reaction vessel and ultrasonically dispersed for 15 min. 1.8 L of phosphate buffer solution with a pH of 7.8 was added, and the mixture was stirred at 250 r / min for 30 min at 3 °C. 200 mL of the medical compound enzyme aqueous solution was added, and the reaction was continued for 3 h at the same temperature and stirring rate. After the reaction was completed, the solid was collected by centrifugation and freeze-dried to constant weight to obtain enzyme-essential oil cyclodextrin composite powder.

[0026] S4: Place 5g sodium citrate (chelating agent), 22g sodium fatty alcohol polyoxyethylene ether sulfate (surfactant) and 60g deionized water in a reaction vessel, stir at 300r / min for 50min at 45℃, cool to 30℃, add 2g sorbitol (enzyme stabilizer) and 8g enzyme-essential oil cyclodextrin composite powder, stir at 150r / min for 25min at the same temperature, let stand to defoam for 15min, and obtain a medical linen-specific antibacterial and environmentally friendly detergent.

[0027] Example 3: This example provides a special antibacterial and environmentally friendly detergent for medical linens, prepared through the following steps: S1: 110g of β-cyclodextrin and 450mL of 8wt% sodium hydroxide aqueous solution were placed in a reaction vessel and stirred at 300r / min for 1.5h at 35℃. 20g of polyethylene glycol was added and reacted at the same temperature and stirring rate for 15min. 60mL of epichlorohydrin was added and reacted at 60℃ at the same stirring rate for 5h. After the reaction was completed, the mixture was cooled to room temperature, filtered, and the solid was washed with deionized water until the last wash was neutral. The solid was transferred to a Soxhlet extractor and extracted with anhydrous ethanol for 24h. The solid was then vacuum dried at 60℃ to constant weight, ground, and sieved through a 200-mesh sieve to obtain a porous β-cyclodextrin polymer.

[0028] S2: Place 8g of tea tree essential oil and 120mL of ethanol in a reaction vessel under nitrogen atmosphere protection, add 500mL of deionized water, and stir and emulsify at 2000r / min at 5℃ for 20min. Add 60g of β-cyclodextrin porous polymer, and react at 35℃ with the same stirring rate in the dark for 8h. After the reaction is completed, centrifuge and collect the solid. Wash the solid with deionized water 4 times and freeze-dry to constant weight to obtain essential oil-loaded cyclodextrin polymer powder.

[0029] S3: Alkaline protease, alkaline lipase, and alkaline cellulase were mixed at an enzyme activity ratio of 3:2:1, and then a phosphate buffer solution with a pH of 7.8 was added to form a medical compound enzyme aqueous solution with a total protein concentration of 5 mg / mL, which was set aside for later use. 60 g of essential oil cyclodextrin polymer powder and 400 mL of deionized water were placed in a reaction vessel and ultrasonically dispersed for 20 min. 2 L of phosphate buffer solution with a pH of 7.8 was added, and the mixture was stirred at 300 r / min for 40 min at 5 °C. 250 mL of the medical compound enzyme aqueous solution was added, and the reaction was continued for 4 h at the same temperature and stirring rate. After the reaction was completed, the solid was collected by centrifugation and freeze-dried to constant weight to obtain enzyme-essential oil cyclodextrin composite powder.

[0030] S4: Place 8g sodium citrate (chelating agent), 30g sodium fatty alcohol polyoxyethylene ether sulfate (surfactant) and 80g deionized water in a reaction vessel, stir at 400r / min for 60min at 50℃, cool to 35℃, add 3g sorbitol (enzyme stabilizer) and 10g enzyme-essential oil cyclodextrin composite powder, stir at 200r / min for 30min at the same temperature, let stand to defoam for 20min, and obtain a medical linen-specific antibacterial and environmentally friendly detergent.

[0031] Comparative Example 1: The difference from Example 2 is that in step S2, commercially available β-cyclodextrin was used instead of the β-cyclodextrin porous polymer prepared in step S1, while the other steps remained unchanged, to prepare a medical linen-specific antibacterial and environmentally friendly detergent.

[0032] Comparative Example 2: The difference from Example 2 is that tea tree oil is not added in step S2, but is replaced by an equal mass of ethanol. The other steps remain unchanged, resulting in a medical linen-specific antibacterial and environmentally friendly detergent.

[0033] Comparative Example 3: The difference from Example 2 is that the medical compound enzyme aqueous solution is not added in step S3, but replaced by an equal mass of phosphate buffer solution with a pH of 7.8. The other steps remain unchanged, and a special antibacterial and environmentally friendly detergent for medical linens is obtained.

[0034] Comparative Example 4: The difference from Example 2 is that the loaded essential oil cyclodextrin polymer powder is not added in S3. Instead, tea tree essential oil and medical compound enzyme aqueous solution are directly mixed and then replaced with an equal mass of deionized water. The other steps remain unchanged to obtain a medical linen-specific antibacterial and environmentally friendly detergent.

[0035] The β-cyclodextrin purchased in the above examples and comparative examples was produced by Hebei Changxinghang Biotechnology Co., Ltd., and is food-grade β-cyclodextrin with CAS number 7585-39-9; polyethylene glycol was produced by Nantong Zimeng Chemical Co., Ltd., with an average molecular weight of 4000; tea tree oil was produced by Jiangxi Jingwang Natural Fragrance Co., Ltd., and is premium-grade tea tree oil; alkaline protease was produced by Cangzhou Xiasheng Enzyme Biotechnology Co., Ltd., with an enzyme activity ≥200000U / g, catalog number FDG-2202; alkaline lipase was produced by Cangzhou Xiasheng Enzyme Biotechnology Co., Ltd., with an enzyme activity ≥50000U / g, catalog number GFY-3310; alkaline cellulase was produced by Cangzhou Xiasheng Enzyme Biotechnology Co., Ltd., with an enzyme activity ≥10000U / g, catalog number GFY-3311; and sodium fatty alcohol polyoxyethylene ether sulfate was produced by Wuhan Jiyesheng Chemical Co., Ltd., and is a daily chemical grade surfactant with an active ingredient content of 70%.

[0036] Phosphate buffer is prepared from disodium hydrogen phosphate and sodium dihydrogen phosphate, and is used after adjusting the pH to 7.8.

[0037] The antibacterial and environmentally friendly detergents for medical linens prepared in Examples 1-3 and Comparative Examples 1-4 were subjected to performance tests. The test results are shown in Table 1. Antibacterial rate: The antibacterial rate of the detergent was tested in accordance with the standard QB / T 2738-2023 "Evaluation Method for Antibacterial and Antimicrobial Effects of Daily Chemical Products". The test environment was 37℃±1℃, and the bacterial strains were Staphylococcus aureus and Escherichia coli. The strain number of Escherichia coli was ATCC 8739, and the strain number of Staphylococcus aureus was ATCC 6538.

[0038] Detergency: Referring to standard GB / T 13174-2021 "Determination of detergency and recycle performance of detergents for clothing", JB-01, JB-02 and JB-03 standard soiled cloths were used, and the detergency ratio was calculated based on the difference in whiteness before and after washing. The higher the detergency ratio, the stronger the detergency of the detergent.

[0039] Enzyme activity retention rate: Referring to the standards GB / T 23527.1-2023 "Quality requirements for enzyme preparations - Part 1: Protease preparations", GB / T 23527.2-2025 "Quality requirements for enzyme preparations - Part 2: Lipase preparations" and QB / T 2583-2023 "Cellulase preparations", the initial enzyme activity in the detergent and the enzyme activity after storage at 25℃±2℃ for 30 days were determined, and the relative enzyme activity retention rate was calculated.

[0040] Stability: Referencing standard QB / T 1224-2012 "Liquid Detergents for Clothing", the test environment was 40℃±2℃ and -5℃±2℃, and the appearance characterization of the detergent was observed.

[0041] Table 1 Performance Test Table of Antibacterial and Environmentally Friendly Detergent for Medical Linen Use As shown in Table 1, the antibacterial and environmentally friendly detergents for medical linens prepared in Examples 1-3 maintain a high antibacterial rate while also possessing excellent detergency and enzyme activity stability. This indicates that the present invention utilizes the cross-linked framework and mesoporous network of β-cyclodextrin porous polymers to first encapsulate tea tree oil within the cyclodextrin cavity and mesopores, and then immobilizes the medical composite enzyme within the carrier channels, achieving spatial isolation between the oil and the enzyme. The oil is released slowly after encapsulation, providing long-lasting antibacterial efficacy, while the enzyme, through the channel confinement effect, reduces direct contact with surfactants, maintaining stable activity, thereby ensuring the detergency and long-lasting antibacterial effect of the medical linen detergent.

[0042] In Comparative Example 1, after replacing the β-cyclodextrin porous polymer with commercially available β-cyclodextrin, the essential oil inclusion capacity and enzyme loading were significantly reduced due to the lack of cross-linked backbone and mesoporous network. Furthermore, the commercially available β-cyclodextrin powder has good water solubility and is difficult to form a stable solid phase dispersion in the detergent liquid phase, resulting in a significant decrease in antibacterial rate, a decrease in detergency ratio, a significant decrease in the relative enzyme activity of the three enzymes, and a deterioration in appearance stability at high and low temperatures, with the appearance of stratified precipitation.

[0043] In Comparative Example 2, although the complete mesoporous structure and enzyme immobilization sites were preserved after the removal of tea tree oil, the detergency ratio and enzyme activity remained relatively stable, and the appearance stability of the system was not significantly affected. However, due to the lack of hydrophobic antibacterial components, the antibacterial rates of Staphylococcus aureus and Escherichia coli were significantly reduced. This indicates that the sustained-release antibacterial efficacy provided by tea tree oil after being encapsulated by cyclodextrin cavity is the core guarantee for the hygiene and safety of medical linen detergents.

[0044] In Comparative Example 3, after the medical compound enzyme loading was removed, although the tea tree oil was still encapsulated in the carrier to maintain a high level of antibacterial rate and the system appearance stability remained homogeneous, the lack of synergistic catalysis by alkaline protease, alkaline lipase and cellulase resulted in the loss of enzymatic cleaning ability for protein and lipid stains, leading to a significant decrease in the cleaning ratio. Furthermore, the relative enzyme activities of the three enzymes all dropped to zero. This indicates that the immobilized medical compound enzyme is a necessary component for achieving efficient enzymatic removal of stains from medical linens.

[0045] In Comparative Example 4, tea tree essential oil was directly mixed with medical compound enzymes and added to the system without cyclodextrin cavity pre-encapsulation and pore confinement immobilization. The small molecules of essential oil directly contacted the active sites of enzyme proteins, destroying the hydrophobic core of the enzymes and adsorbing them onto the active sites, resulting in a significant reduction in the relative enzyme activities of the three enzymes. At the same time, the essential oils were unevenly dispersed and easily volatile due to the lack of carrier encapsulation, resulting in a decrease in the effective antibacterial concentration. The detergency ratio was also reduced due to enzyme inactivation, which significantly reduced the effectiveness of the detergent.

[0046] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention.

Claims

1. A special antibacterial and environmentally friendly detergent for medical linens, characterized in that: By weight, it includes the following raw materials: 5-10 parts of enzyme-essential oil cyclodextrin composite powder; 15-30 parts of sodium fatty alcohol polyoxyethylene ether sulfate; Sodium citrate 2-8 parts; 1-3 parts of sorbitol; 40-80 parts deionized water; The enzyme-essential oil cyclodextrin composite powder is prepared by first encapsulating β-cyclodextrin with tea tree oil and then immobilizing it with a medical composite enzyme under alkaline conditions through polyethylene glycol pore formation and epichlorohydrin crosslinking to form a porous polymer.

2. The antibacterial and environmentally friendly detergent for medical linens according to claim 1, characterized in that, The specific preparation process of the enzyme-essential oil cyclodextrin composite powder is as follows: The loaded essential oil cyclodextrin polymer powder and deionized water were placed in a reaction vessel and ultrasonically dispersed for 10-20 min. A phosphate buffer solution with a pH of 7.8 was added, and the mixture was stirred at 0-5℃ for 20-40 min. A medical compound enzyme aqueous solution was added, and the reaction was continued at the same temperature for 2-4 h. The mixture was centrifuged, the solid was collected, and freeze-dried to constant weight to obtain the enzyme-essential oil cyclodextrin composite powder.

3. The antibacterial and environmentally friendly detergent for medical linens according to claim 2, characterized in that, The ratio of the loaded essential oil cyclodextrin polymer powder, deionized water, phosphate buffer solution and medical compound enzyme aqueous solution is 40-60g: 200-400mL: 1.5-2L: 150-250mL.

4. The antibacterial and environmentally friendly detergent for medical linens according to claim 3, characterized in that, The specific preparation process of the medical compound enzyme aqueous solution is as follows: Alkaline protease, alkaline lipase, and alkaline cellulase were mixed at an enzyme activity ratio of 3:2:1, and then added to a phosphate buffer solution with a pH of 7.8 to obtain a medical compound enzyme aqueous solution.

5. The antibacterial and environmentally friendly detergent for medical linens according to claim 4, characterized in that, The total protein concentration in the aqueous solution of the medical compound enzyme is 2-5 mg / mL.

6. The antibacterial and environmentally friendly detergent for medical linens according to claim 3, characterized in that, The specific preparation process of the essential oil-loaded cyclodextrin polymer powder is as follows: Tea tree essential oil and ethanol were placed in a reaction vessel under nitrogen atmosphere protection, deionized water was added, and the mixture was stirred and emulsified at 0-5℃ for 10-20 min. β-cyclodextrin porous polymer was added, and the mixture was reacted at 25-35℃ in the dark for 6-8 h. After centrifugation, the solid was collected, washed, and freeze-dried to constant weight to obtain essential oil-loaded cyclodextrin polymer powder.

7. The antibacterial and environmentally friendly detergent for medical linens according to claim 6, characterized in that, The ratio of tea tree oil, ethanol, deionized water and β-cyclodextrin porous polymer is 6-8g: 80-120mL: 300-500mL: 40-60g.

8. The antibacterial and environmentally friendly detergent for medical linens according to claim 6, characterized in that, The specific preparation process of the β-cyclodextrin porous polymer is as follows: β-Cyclodextrin and an 8wt% sodium hydroxide aqueous solution were placed in a reaction vessel and stirred at 25-35℃ for 0.5-1.5 h. Polyethylene glycol was added and stirred at the same temperature for 5-15 min. Epichlorohydrin was added and reacted at 50-60℃ with the same stirring rate for 3-5 h. The mixture was filtered, washed, extracted with anhydrous ethanol, vacuum dried to constant weight, ground and sieved to obtain a porous β-cyclodextrin polymer.

9. The antibacterial and environmentally friendly detergent for medical linens according to claim 8, characterized in that, The ratio of β-cyclodextrin, sodium hydroxide aqueous solution, polyethylene glycol, and epichlorohydrin is 90-110g: 350-450mL: 10-30g: 40-60mL.

10. The formulation process of the antibacterial and environmentally friendly detergent for medical linens according to claim 1, characterized in that, Includes the following steps: Sodium citrate, sodium fatty alcohol polyoxyethylene ether sulfate, and deionized water are placed in a reaction vessel and stirred at 40-50℃ for 40-60 minutes. The mixture is then cooled to 25-35℃, and sorbitol and enzyme-essential oil cyclodextrin composite powder are added. The mixture is stirred at the same temperature for 20-30 minutes and allowed to stand to defoam, thus obtaining a special antibacterial and environmentally friendly detergent for medical linens.

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