Drug-containing hydrophobic oral care composition

Abstract

A composition for oral care is provided having medium chain triglycerides, a hydrophobic antimicrobial agent, and a hydrophobic flavoring agent.

Description

Technical Field

[0001] This disclosure generally relates to compositions for oral care that contain various hydrophobic components.

[0002] background

[0003] Most oral care compositions, including mouthwashes, flossers, and mouth sprays, are water-based. Therefore, the components in water-based oral care compositions have difficulty penetrating the biofilm lining the mouth and teeth. Hydrophobic compositions tend to be more viscous, which may cause discomfort to some consumers.

[0004] summary

[0005] According to various aspects, a composition for oral care is provided, comprising medium-chain triglycerides, hydrophobic antimicrobial agents and hydrophobic flavoring agents, hydrophobic herbal extracts and hydrophobic vitamins. Brief description of the attached diagram

[0007] Figure 1 The diagram illustrates methods for preparing oral care compositions according to various implementation schemes.

[0008] Figure 2 and 3 The antimicrobial properties of oral care compositions according to various implementation schemes are explained.

[0009] Figure 4 The teeth whitening of oral care compositions according to various implementation schemes is explained.

[0010] Figure 5 and 6 The odor reduction of the antimicrobial properties of oral care compositions according to various implementation schemes is explained.

[0011] Figure 7 The teeth whitening of oral care compositions according to various implementation schemes is explained.

[0012] Detailed description

[0013] definition

[0014] The following is a list of definitions for the terms used herein. Unless otherwise defined, all technical and scientific terms used herein generally have the same meaning as commonly understood by one of ordinary skill in the art. Where multiple definitions exist for a term herein, those definitions in this section shall prevail, unless otherwise stated. Generally, the nomenclature used herein, as well as laboratory procedures in cytopathic analysis, microbiological analysis, organic, physical and inorganic chemistry, and dental clinical research, are those well-known and commonly used in the art.

[0015] As used herein, the term “about” will be understood by those skilled in the art and will vary to some extent depending on the context in which it is used. Generally, “about” covers a range of values ​​plus or minus 10% of a reference value, unless explicitly stated otherwise. For example, “about 25%” covers values ​​from 22.5% to 27.5%.

[0016] As used in this article, “ambient conditions” refers to approximately room temperature (e.g., 20–35°C) and approximately <70% relative humidity.

[0017] As used in this article, “reasonable time period” refers to the period during which, depending on the application, the composition can be expected to maintain a safe and effective amount of its components, ranging from several months to several years.

[0018] The terms “stable for shelf life” and “stable for shelf life” are used interchangeably in this document and indicate that a multi-component composition is considered acceptable to consumers after a specified period of time following its production (under environmental conditions).

[0019] As used herein, “bioavailability” refers to the extent to which an active agent in a composition is absorbed or permeates into the organic matter to which it is exposed, and / or the proportion of the composition’s dose that reaches the systemic circulation of the organic matter to which it is intended for application. For example, when a composition is administered intravenously, its bioavailability is close to 100%, while when the composition is administered topically, a portion of the total composition reaches the systemic circulation. The term “bioavailability” also refers to the utilization of its potency at the target site, as well as its utilization of potency intracellularly, extracellularly, or in biological fluids / biological fluids.

[0020] As used herein, “biocidal,” “bactericidal,” “fungicide,” or the synonymous term, refers to the ability to inactivate or kill microorganisms such as bacteria, algae, yeast, and fungi. As used herein, “biocidal” also indicates the effect of the composition as a therapeutic means of reducing the growth or overgrowth of bacteria or fungi or microorganisms in fluids or biofilms, which may be associated with alleviating a disease condition or state.

[0021] As used herein, "antimicrobial" refers to the ability to inactivate or kill microorganisms (such as viruses, bacteria, algae, yeast, and fungi). "Biocidal" as used herein also indicates the effect of the composition as a therapeutic means of reducing the growth or overgrowth of bacteria or fungi or other microorganisms in fluids or biofilms, which may be associated with alleviating a disease condition or state.

[0022] As used herein, “bio-inhibiting,” “bacterial-inhibiting,” “fungal-inhibiting,” or synonymous terms refer to the property of inhibiting the growth of microorganisms such as bacteria, algae, yeast, and fungi. “Bio-inhibiting” as used herein indicates the role of the composition in maintaining a multimicrobial mixture of fluids or biofilms, such as maintaining oral ecology, so that one or more organisms do not overgrow and cause infection and disease. Compositions with bio-inhibiting properties contribute to maintaining health, promoting health, and preventing infection and disease.

[0023] As used in this article, "biofilm" refers to a biocluster that forms a layer on a surface, containing a community of microorganisms embedded in an extracellular matrix of polymers and / or other biological compounds, such as glycoproteins. Typically, biofilms contain a variety of microorganisms, including bacteria (aerobic and anaerobic), algae, protozoa, yeast, and fungi. While monospecies biofilms also exist, biofilms within the body can evolve over time into multimicrobial biofilms, creating an anaerobic environment in which anaerobic pathogens thrive, while the biofilm matrix protects the multimicrobial mixture from antimicrobial treatments.

[0024] As used in this article, “carrier” refers to those components in a composition that can be mixed together to provide the desired physical consistency and good consumer performance without interacting with other components.

[0025] As used herein, “orally acceptable carrier” means a suitable medium or component that can be used to form the composition and / or apply the composition to the oral cavity in a safe and effective manner.

[0026] As used herein, “compatible” means that the components of a composition can be mixed together without interacting in any way that would significantly reduce the stability of the oral care composition, the ingredients, carriers and excipients required for its efficacy, and the consumer quality of the composition.

[0027] As used herein, “consumer-friendly performance” includes, but is not limited to, the appearance, viscosity, taste, odor, abrasiveness, color, flavor, and moisturizing properties of a composition that consumers consider ideal through consumer product testing or other similar means. For example, it may be desirable for the toothpaste tube to form a strip of paste on the toothbrush when squeezed, and for the toothpaste composition to be neither too stiff to be difficult to squeeze out of the tube nor too viscous to remain or stay on the toothbrush for use.

[0028] In this article, "dental plaque" refers to a multimicrobial biofilm that forms on the surface of teeth.

[0029] As used in this article, "substantially not containing" refers to a composition that contains very low levels of a particular ingredient, compound, or molecule, below the detection levels of commonly used analytical methods.

[0030] As used herein, “mediation” refers to an orally acceptable mediation for preparing a dental cleaning composition comprising an aqueous phase (in which a humectant is contained).

[0031] As used in this article, “dental cleaning agent” refers to a paste, gel, powder, tablet or liquid preparation used for cleaning the oral cavity, unless otherwise indicated.

[0032] The term “teeth” as used in this article refers to both natural teeth and artificial teeth or dental prostheses.

[0033] As used herein, "effective amount" means any amount of an agent that can produce the desired biocidal or bioinhibitory effect, or chemical or physiological effect, desired cosmetic effect, and / or desired therapeutic biological effect. In one embodiment, an effective amount of an agent for teeth whitening may be the amount that whitens teeth after one or more treatments. In another embodiment, an effective amount of an agent for wound treatment is the amount that may statistically significantly improve wound healing.

[0034] As used in this article, "thin film" refers to a material layer with two dimensions that are much greater than a third dimension. Thin films can be liquid or solid materials. For some materials, liquid thin films can be transformed into solid thin films through curing (e.g., through phenomena such as evaporation, heating, drying, crosslinking, adhesion, adduct formation, etc.).

[0035] As used in this article, “hard tissue” refers to any toenails and nails, hard keratinized tissue, hard dental tissue, bones, teeth, etc., found in animals (such as mammals).

[0036] The term “substantially not containing” as used in this article means that a given substance is included in unavoidable levels, but not excessively.

[0037] As used in this article, “substantially not containing” means no more than 0.5% by weight of the given substance.

[0038] As used herein, “irritant” and “irritant” refer to the property of causing a local inflammatory response (such as redness, swelling, itching, burning, or blistering) upon immediate, prolonged, or repeated contact. For example, inflammation of non-oral mucosa or skin tissue in mammals may indicate irritation to that tissue. A composition may be considered “substantially non-irritating” or “substantially non-irritating” if any standard method for assessing skin or mucosal irritation is used to determine that the composition is slightly irritating or non-irritating.

[0039] As used in this article, "pharmaceutically acceptable" has a broad meaning and refers to, but is not limited to, compounds, materials, compositions, and / or dosage forms that, to a reasonable extent of medical judgment, are suitable for contact with and / or consumption in human and animal tissues without excessive toxicity, irritation, allergic responses, or other problematic complications, and have a reasonable risk / benefit ratio.

[0040] The abbreviation “ppm” used in this article refers to parts per million, by weight or volume, where applicable.

[0041] As used in this article, “overgrowth” refers to the excessive aggregation of bacteria, algae, yeast, and / or fungi, leading to inflammation, infection, morbidity, and disease. Overgrowth can occur in biofilms and plaques containing a multimicrobial mixture of bacteria, algae, yeast, and / or fungi, such as those found in biofilms associated with mucositis and dental plaque. It is known that the overgrowth of pathogenic microorganisms within biofilms can significantly increase their resistance to treatment and increase the incidence of inflammatory tissues, infections, and diseases.

[0042] As used in this article, "preventative" refers to treatment administered to subjects who do not exhibit disease symptoms or who exhibit early symptoms of the disease, with the aim of reducing the risk of developing pathologies associated with the disease.

[0043] As used in this article, “range” refers to the range of variation between the upper and lower limits of a particular scale. It should be understood that this article includes any and all whole or partial integers between any ranges listed herein.

[0044] As used herein, “safe and effective amount” and similar terms refer to an amount of the component in a composition that positively improves the condition being treated, but is low enough to be safely used in humans and animals without serious side effects (within a reasonable benefit / risk ratio) and within reasonable medical / dental judgment. “Safe and effective” refers not only to the amount of one or more active compounds administered, but also to their rate of administration (release rate).

[0045] As used herein, "single-phase composition" refers to a composition in which all components are prepared in a single container and are not subsequently mixed with other components. Therefore, a single-phase composition can be used directly at any time within its shelf life without further preparation or mixing. The bioavailability of a single-phase composition can be determined at any point within its effective shelf life.

[0046] As used herein, "stability" refers to the prevention of the components contained in an oral care composition from reacting, diminishing, or degrading. An oral care composition is considered "stable" if the components do not react with each other within a reasonable timeframe. For example, an oral care composition is considered stable if it maintains consumer quality for 24 months at approximately 25°C (ambient temperature), or for 6 months at an accelerated temperature of 40°±2°C and a relative humidity of 75%±5% (RH).

[0047] As used herein, “shelf life” refers to the length of time a composition maintains the required stability of its constituent compounds and the consumer quality of the composition.

[0048] The term "therapeutic" as used in this article refers to treatment of subjects exhibiting pathological symptoms with the aim of alleviating or eliminating those symptoms.

[0049] As used herein, “topical composition” refers to a product that is not intentionally ingested or otherwise applied without being recovered for systemic application of a therapeutic agent, but is retained in the anus, vagina, ear, mouth, nose, eye, or genitourinary cavity, or on the skin or other external body surface, or in an affected soft tissue area, for a duration sufficient to contact substantially all surfaces and / or tissues for the application and delivery of a therapeutic agent.

[0050] As used herein, “trauma” means a laceration, abrasion, puncture wound, burn, and / or other injury to any one or more soft and / or hard tissues. Exemplary tissues considered for the treatment of such trauma include mucous membranes and dermis, the dermis comprising epidermal tissue, dermal tissue, and subcutaneous tissue (also referred to as hypodermal tissue). Trauma as used herein also encompasses lacerations, puncture wounds, and / or avulsions of the fingernail or toenail. Trauma can partially or completely penetrate tissue. Trauma can be caused accidentally or intentionally, such as surgical trauma.

[0051] As used in this article, "dispersant" refers to a compound that improves particle separation and prevents one or more components in a multi-component composition from settling or agglomerating.

[0052] As used in this article, "moisturizer" refers to a compound that reduces water loss from the composition.

[0053] As used in this article, "suspending agent or emulsifier" refers to a compound that uniformly disperses one or more components in a multi-component composition.

[0054] As used in this article, "fragrance agent" refers to a compound that provides a pleasant odor or atmosphere (order) to a composition.

[0055] As used in this article, “medium-chain triglycerides” and “MCT” refer to medium-chain fatty acids esterified with the glycerol backbone. MCTs include hexanoic acid (6 carbons or C6), octanoic acid (8 carbons or C8), decanoic acid (10 carbons or C10), and lauric acid (12 carbons or C12).

[0056] As used herein, "fractionated coconut oil" means coconut oil that has been processed to remove at least fatty acids having more than 12 carbon atoms. Those skilled in the art will understand that fractionated coconut oil may include lauric acid, or fractionated coconut oil may be substantially free of and / or substantially free of lauric acid.

[0057] As used in this article, “coolant” refers to a compound that provides cooling, soothing, or comfort when the composition is applied topically to hard and soft tissues.

[0058] The term "warming agent" as used in this article refers to compounds that produce an olfactory sensation, especially a warming sensation. Warming agents are commonly required in various cosmetic formulations, such as shaving creams, hand creams, lotions, facial preparations (including masks), and depilatory agents.

[0059] As used herein, "humectant" refers to a compound that retains moisture in a composition. Some embodiments described herein include one or more compounds such as cellulose gum, carboxymethyl cellulose, pectin, guar gum, xanthan gum, N-acylsarcosine salt, sodium lauroyl sarcosine, sodium cocoyl sarcosine, or sodium myristoyl sarcosine.

[0060] As used in this article, "thickener" refers to a compound that increases the viscosity of a composition.

[0061] As used herein, “excipient” refers to a compound that imparts physical and consumer-desirable properties to a composition, making it acceptable to consumers. Examples of such properties are (but are not limited to) viscosity, appearance, taste, color, consistency, sweetness, gel structure, preservatives, homogeneous suspensions, or combinations thereof.

[0062] As used in this article, the term "abrasive" refers to a compound that, when brushed with a composition such as toothpaste, helps to remove coatings (or deposits) from hard or soft tissues, such as those on the surface of teeth.

[0063] As used in this article, "desensitizing agents" refers to compounds that help reduce or alleviate sensitivity and pain. For example, desensitizing agents in topical resins, varnishes, toothpastes, or mouthwashes may clog dentinal tubules or desensitize nerve fibers, thereby blocking nerve conduction.

[0064] As used in this article, "functional agent" refers to a compound that enhances health or aesthetics. For example, a functional agent can be... For instance, desensitizing agents in topical resins, varnishes, toothpastes, or mouthwashes may clog dentinal tubules or desensitize nerve fibers, thereby blocking nerve conduction.

[0065] Unless otherwise stated, all percentages and ratios used herein are by weight of the multi-component composition, not by weight of the delivered monolithic topical formulation. All measurements were performed at room temperature (i.e., 20–25 °C) unless otherwise stated. Under normal conditions, heat and humidity can cause such compositions to degrade from a liquid to a gaseous state, altering their weight and rendering ordinary measurement calculations inaccurate.

[0066] Detailed description of the implementation plan

[0067] In various embodiments, hydrophobic compositions for oral use are disclosed herein, comprising functional agents and being better absorbed by the oral mucosa compared to aqueous oral care products. In various embodiments, hydrophobic compositions for oral use are disclosed herein, comprising functional agents with antimicrobial properties and being better absorbed by the oral mucosa compared to aqueous oral care products. As disclosed herein, hydrophobic compositions may penetrate oral biofilms better than aqueous solutions. Furthermore, hydrophobic compositions may improve absorption through the oral mucosa. Many pathogens found in the oral cavity tend to have hydrophobic membranes, and therefore, these pathogens are more easily absorbed in hydrophobic solutions than in aqueous solutions. Additionally, hydrophobic solutions may deliver vitamin D3 and vitamin K3, which aid in calcium absorption by bones. This is particularly useful for individuals with dental implants or degenerative bone diseases, as oral care compositions containing hydrophobic solutions and vitamins D3 and K3 can help strengthen oral bones by stimulating calcium absorption.

[0068] Lipid-based oral care compositions penetrate tooth biofilms better than aqueous solutions. This means that lipid-based oral care compositions can deliver carefully selected materials directly to and through the biofilm and harmful bacteria living inside or behind it. The components of lipid-based oral care compositions are themselves hydrophobic or otherwise soluble in oils, particularly MCT oils as described below. In this respect, the lipid-based oral care compositions disclosed herein may be more effective and improve oral health than aqueous oral care compositions. Furthermore, the cell membranes of animals, including mammals, are primarily composed of lipids. Because lipids tend to attract other lipids, lipid-based oral care compositions tend to bind to or otherwise contact animal cell membranes with improved effectiveness compared to aqueous solutions. In this respect, bacterial cell membranes also contain lipids, and therefore, lipid-based oral care compositions tend to have a greater affinity for bacterial cell membranes compared to aqueous solutions. In the case where the lipid-based oral care composition contains antimicrobial agents, this affinity between the lipid-based oral care composition and the bacterial cell membrane improves the delivery and efficacy of the antimicrobial agent.

[0069] Furthermore, lipid-based oral care compositions have the advantage of delivering oil-soluble vitamins to oral tissues over aqueous oral care compositions. In this regard, vitamins such as D3, K2, E, and A can be dissolved in lipid-based oral care compositions, which, as described above, are able to penetrate biological membranes and deliver these oil-soluble vitamins to oral tissues that aqueous oral care compositions would otherwise be unable to reach.

[0070] In various embodiments, the oral care composition is substantially free of and / or substantially free of water. In various embodiments, the oral care composition is substantially free of hydrophilic materials. In various embodiments, the oral care composition contains one or more hydrophilic agents. For example, in various embodiments, the oral care composition may contain hydrophilic flavoring agents, antimicrobial agents, and / or functional agents. However, in various embodiments, the oral care composition does not contain hydrophilic flavoring agents, antimicrobial agents, and / or functional agents.

[0071] In various embodiments, the oral care composition comprises a lipid-based solvent, and in various embodiments, the lipid-based solvent comprises a mixture of medium-chain triglycerides, the mixture comprising at least one medium-chain triglyceride.

[0072] In various embodiments, the medium-chain triglyceride mixture comprises fractionated coconut oil that is substantially free of and / or substantially free of fatty acids having more than 12 carbon atoms. In other words, in various embodiments, the medium-chain triglyceride mixture is substantially free of and / or substantially free of fatty acids having more than 12 carbon atoms and comprises at least one of capric acid, caprylic acid, lauric acid, and various mixtures thereof. In various embodiments, the medium-chain triglyceride mixture comprises fractionated palm oil. In various embodiments, the medium-chain triglyceride mixture comprises medium-chain triglycerides from any plant source, including coconut and palm.

[0073] In various embodiments, the medium-chain triglyceride mixture comprises fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms. In other words, in various embodiments, the medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of decanoic acid, caprylic acid, and various mixtures thereof. The medium-chain triglyceride mixture can range from 100% by weight of caprylic acid and 0% by weight of decanoic acid to 100% by weight of decanoic acid and 0% by weight of caprylic acid. In various embodiments, the medium-chain triglyceride mixture is from about 60% decanoic acid and 40% caprylic acid to about 60% caprylic acid and 40% decanoic acid.

[0074] Fractionated coconut oil that substantially contains no and / or essentially contains no fatty acids with 12 or more carbon atoms tends to have a lower viscosity than coconut oil containing lauric acid or fractionated coconut oil. The lower viscosity may be more acceptable to consumers for use in the oral cavity.

[0075] Lauric acid is known to exhibit antimicrobial properties. In this regard, in embodiments using fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 carbon atoms, functional agents, such as one or more hydrophobic antimicrobial agents, and / or their weight percentage can be increased, instead of using formulations containing lauric acid. For example, in preparation embodiments using fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 carbon atoms, a variety of hydrophobic antimicrobial agents (e.g., tea tree oil and oregano oil) can be used, and / or it may be necessary to increase the weight percentage of such hydrophobic antimicrobial agents relative to the weight percentage of hydrophobic antimicrobial agents used in embodiments containing lauric acid.

[0076] In various embodiments, the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having more than 12 carbon atoms may be present in an amount from about 0.01% to about 99% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% to about 90%). In various embodiments, the amount of the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having more than 12 carbon atoms may be from about 80% to about 99%, about 85% to about 98%, or about 88% to about 98% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having more than 12 carbon atoms relative to the total weight of the oral care composition.

[0077] In various embodiments, the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms may be present in an amount from about 0.01% to about 99% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% to about 90%). In various embodiments, the amount of the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms may be from about 80% to about 99%, about 85% to about 98%, or about 88% to about 98% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms relative to the total weight of the oral care composition.

[0078] In various embodiments, the fractionated coconut oil may comprise hexanoic acid and lauric acid and / or consist substantially of hexanoic acid and lauric acid. Hexanoic acid and lauric acid together may be present in the oral care composition at a weight percentage of about 0.01% to about 99% (e.g., about 0.01%, 0.1%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80% to about 90%). In various embodiments, the amount of fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms may be about 80% to about 99%, about 85% to about 98%, or about 88% to about 98% of the oral care composition by weight. For the avoidance of confusion, the values ​​listed herein are weight percentages of fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms relative to the total weight of the oral care composition.

[0079] In various embodiments, the oral care composition comprises at least one functional agent. The functional agent may comprise one or more of antimicrobial agents, flavoring agents, saliva stimulants, hydrophobic herbal extracts, and / or vitamins.

[0080] In various embodiments, the oral care composition comprises a functional agent, which includes a hydrophobic antimicrobial agent. The hydrophobic antimicrobial agent can be an antimicrobial agent soluble in fractionated coconut oil that is substantially free of fatty acids having 12 or more carbon atoms at 25°C. The hydrophobic antimicrobial agent comprises essential oils such as plant essential oils, for example, clove oil, oregano oil, tea tree oil (also known as tamarisk oil), thyme oil, myrrh oil, eucalyptus oil, cinnamon oil, and / or combinations thereof. Clove oil is rich in eugenol, which has various antimicrobial properties. Furthermore, oregano oil and tea tree oil are known to have antimicrobial properties. Oregano oil contains various terpenes, phenols, and terpenoid compounds. For example, oregano oil may contain carvacrol, thymol, and rosmarinic acid. Carvacrol is believed to have antibacterial properties, while thymol is believed to have antifungal properties.

[0081] In various embodiments, hydrophobic antimicrobial agents include a variety of synthetic chlorinated substances, various polymers (including peptides), certain organosulfur compounds, and many essential oils. Chlorinated substances include, but are not limited to, triclosan and triclocarban. Antimicrobial polymers include, but are not limited to, bacitracin, buprevir, dabafancin, dapoxetine, enfuviride, ostafrancin, teicoplanin, telaprevir, telavancin, vancomycin, and guavanin-2. Antimicrobial organosulfur compounds include, but are not limited to, allicin and 3-vinyl-4-ethylhex ... H -1,2-Dithionecyclohexene, 2-vinyl-4 H -1,3-Dithicyclohexene, ajoene, and diallyl disulfides. Hydrophobic antimicrobial essential oils include, but are not limited to, oregano oil, clove oil, orange oil, ageratum oil, lemongrass oil, peppermint oil, tea tree oil, cedarwood oil, lavender oil, eucalyptus oil, lemongrass oil, lemon oil, orange oil, palmarosa oil (…). Cymbopogon martinii Palmarosa oil and patchouli oil.

[0082] In various embodiments, the hydrophobic antimicrobial agent may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the hydrophobic antimicrobial agent may be from about 0.15% to about 1.2%, from about 0.18% to about 1.0%, or from about 0.2% to about 0.3% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the hydrophobic antimicrobial agent relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one hydrophobic antimicrobial agent. The values ​​given herein refer to the sum of the hydrophobic antimicrobial agents in the oral care composition.

[0083] In various embodiments, the oral care composition comprises a functional agent comprising a hydrophobic herbal extract. The herbal extract comprises various phytochemicals extracted from herbs and / or other plants. In various embodiments, the hydrophobic herbal extract is hydrophobic. In this respect, the hydrophobic herbal extract may comprise oils, waxes, resins, or other hydrophobic forms, and is otherwise oil-soluble, for example, soluble in MCT. In various embodiments, the oral care composition comprises a hydrophobic herbal extract extracted using supercritical carbon dioxide (CO2). Supercritical carbon dioxide extraction involves placing plant material in a carbon dioxide environment at temperatures and pressures above the carbon dioxide critical point to form a supercritical fluid. Thus, supercritical carbon dioxide penetrates the plant material and extracts various components from the plant material, including various hydrophobic substances. The supercritical carbon dioxide containing the extract can be boiled in stages, thereby releasing the plant material components into residual oils at each stage. In this respect, the supercritical carbon dioxide can be adjusted in various separation stages to produce fractions of the hydrophobic herbal extract grouped by molecular weight. Thus, the hydrophobic herbal extract can be fractionated into waxes, heavy oils / resins, and light oils. In other words, supercritical carbon dioxide extraction provides an efficient way to extract target components from plant material. In various embodiments, hydrophobic herbal extracts can be fractionated by molecular weight. However, in various embodiments, hydrophobic herbal extracts may contain all or almost all types of substances present in the plant material from which they are extracted. Supercritical carbon dioxide extraction provides the ability to extract a variety of substances from plant material without the use of volatile organic solvents such as hexane or ethanol.

[0084] In various embodiments, the hydrophobic herbal extracts include Ashwagandha extract, Neem extract, Cinnamon extract, Neem extract, Clove extract, Roman chamomile extract, Cardamom extract, Tea tree oil extract, Trifolium repens extract, Phyllanthus emblica extract, Hippophae rhamnoides extract, Licorice, Echinacea extract, Marigold extract, Ginger extract, Portulaca oleracea extract, Schemewan extract, Globe amaranth extract, Thyme extract, Sunflower seed oil extract, and Turmeric root (turmeric) extract. In various embodiments, the hydrophobic herbal extracts include Ashwagandha (Symplocos galanga) extracted with supercritical carbon dioxide, Neem extract extracted with supercritical carbon dioxide, Cinnamon extract extracted with supercritical carbon dioxide, Neem extract extracted with supercritical carbon dioxide, Clove extract extracted with supercritical carbon dioxide, Roman chamomile extract extracted with supercritical carbon dioxide, Cardamom extract extracted with supercritical carbon dioxide, Tea tree extract extracted with supercritical carbon dioxide, Sunflower extract extracted with supercritical carbon dioxide, and Turmeric root extract extracted with supercritical carbon dioxide. While those skilled in the art will know, hydrophobic herbal extracts obtained by supercritical carbon dioxide extraction are substantially free of residual organic solvents used in other extraction methods. Furthermore, hydrophobic herbal extracts obtained by supercritical carbon dioxide extraction may be complete, meaning that such extracts contain all or almost all types of phytochemicals found in the raw plant material; or they may be fractionated, meaning that such extracts contain only some types of phytochemicals found in the raw plant material.

[0085] Supercritical carbon dioxide extracted Ashwagandha contains alkaloids (anaferine, anaferoline, anahygrine), steroidal lactones (safflower lactone, anaferoline), and / or saponins. Supercritical carbon dioxide extracted Ashwagandha is believed to possess anti-inflammatory activity and other positive health benefits. Its application in oral care compositions may help reduce oral inflammation (e.g., gingivitis) and anxiety (which may lead to teeth grinding).

[0086] Turmeric root extracted with supercritical carbon dioxide contains curcuminoids. Supercritical carbon dioxide extracted turmeric root is believed to possess anti-inflammatory activity and other positive health benefits such as anti-anxiety effects. Its application in oral care compositions may help reduce oral inflammation (e.g., gingivitis).

[0087] In various embodiments, supercritical carbon dioxide extracted turmeric root and supercritical carbon dioxide extracted Ashwagandha contain hydrophobic components (e.g., curcumin) that can be dissolved in medium-chain triglycerides and / or medium-chain triglycerides that substantially do not contain and / or substantially do not contain fatty acids having 12 or more carbon atoms. Stirring can be used to dissolve the supercritical carbon dioxide extracted turmeric root and supercritical carbon dioxide extracted Ashwagandha in medium-chain triglycerides and / or medium-chain triglycerides that substantially do not contain and / or substantially do not contain fatty acids having 12 or more carbon atoms. As described herein, the application of medium-chain triglycerides and / or medium-chain triglycerides that substantially do not contain and / or substantially do not contain fatty acids having 12 or more carbon atoms tends to allow the oral care composition to penetrate the biofilm in the oral cavity and on the teeth, thereby reaching the underlying bacteria and other microorganisms. In this respect, the application of medium-chain triglycerides and / or medium-chain triglycerides having more than 10 carbon atoms allows for greater contact between the hydrophobic herbal extracts and oral tissues and oral microorganisms.

[0088] In various embodiments, the hydrophobic herbal extract may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the hydrophobic herbal extract may be from about 0.15% to about 2%, about 0.18% to about 1.5%, or about 0.2% to about 1% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the hydrophobic herbal extract relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one hydrophobic herbal extract. The values ​​given herein refer to the sum of the hydrophobic herbal extracts in the oral care composition.

[0089] In various embodiments, the oral care composition comprises a functional agent, which includes a hydrophobic flavoring agent. The hydrophobic flavoring agent can refer to a flavoring agent that is soluble at 25°C in fractionated coconut oil that substantially contains and / or substantially contains no fatty acids having 12 or more carbon atoms.

[0090] In various embodiments, the hydrophobic flavoring agent comprises essential oils such as plant essential oils, for example, spearmint oil, peppermint oil, cardamom oil, cinnamon oil, rose oil, jasmine oil, orange oil, lemon oil, vanilla oil, and combinations thereof. In various embodiments, suitable flavoring agents may include, for example, fragrances, such as natural fragrance oils, artificial fragrances, and combinations thereof. Non-limiting examples of fragrance oils include spearmint oil, cinnamon oil, wintergreen oil (methyl salicylate), peppermint oil, clove oil, laurel oil, fennel oil, eucalyptus oil, thyme oil, cedarwood oil, nutmeg oil, allspice oil, sage oil, nutmeg bark oil, bitter almond oil, and cinnamon bark oil. Suitable flavoring agents also include, for example, artificial, natural, and synthetic fruit flavorings such as vanilla, citrus oils (e.g., lemon, orange, lime, and grapefruit) and fruit essences (e.g., apple, pear, peach, grape, strawberry, raspberry, cherry, plum, pineapple, and apricot), and combinations thereof.Other flavoring agents that may be included alone or in combination include, for example, anethole, menthol, menthone, L-menthol acetate, eucalyptol, borneol, borneol acetate, camphor, 1,8-cineole, cinnamaldehyde, benzaldehyde, citral, thujone, eugenol, limonene, geraniol, citronellol, citronellol, pinene, linalool, thymol, carvone, caryophyllene, linalyl acetate, methyl salicylate, 3,3,5-trimethylcyclohexanol, methoxycyclohexanol, benzyl alcohol, anisyl alcohol, cinnamyl alcohol, β-phenylethanol (2-phenylethanol), cis-3-hexenol, xylene musk, isoeugenol, methyleugenol, α-pentylcinnamaldehyde, anisaldehyde, n-butyraldehyde, anisaldehyde, cyclamate aldehyde, decanal, isobutyraldehyde, hexanal, heptanal, n-nonanal, nonadienol Hydroxycitronellal, benzaldehyde, methylnonylacetaldehyde, dodecyl alcohol, α-hexylcinnamaldehyde, undecenoal, piperaldehyde, vanillin, ethyl vanillin, methylpentyl ketone, methyl β-naphthyl ketone, methylnonyl ketone, muscone, diacetyl, acetylpropionyl, acetylbutyryl, acetylphenyl, p-methylacetylphenyl, ionone, methyl ionone, pentylbutyrolactone, diphenyl ether, methyl phenyl glycidyl ester, γ-nonyl lactone, coumarin, eucalyptol, ethyl methyl phenyl glycidyl ester, methyl formate, isopropyl formate, linaloyl formate, ethyl acetate, octyl acetate, methyl acetate, benzyl acetate, butyl propionate, isoamyl acetate, isopropyl isobutyrate, geraniol isovalerate, allyl hexanoate, butyl heptaate, octyl caprylate octyl), methyl heptamethoxycarbamate, mesyl octylcarbamate, isomethyl octyl octamethoxycarbamate, methyl laurate, ethyl myristate, methyl myristate, ethyl benzoate, benzyl benzoate, styrax acetate, isobutyl phenylacetate, methyl cinnamate, cinnamyl cinnamate, ethyl anisinate, methyl anthranilate, ethyl pyruvate, ethyl α-butylbutyrate, benzyl propionate, butyl acetate, butyl butyrate, p-tert-butylcyclohexyl acetate, cypress acetate Citronellol acetate, citronellol formate, p-cresol acetate, ethyl butyrate, ethyl hexanoate, ethyl cinnamate, ethyl phenylacetate, vinyl tridecanoate, geraniol acetate, geraniol formate, isoamyl salicylate, isoamyl isovalerate, isoborneol acetate, linaloyl acetate, methyl anthranilate, methyl dihydrojasmonate, β-phenylethyl acetate, trichloromethylphenylmethanol acetate, terpineol acetate, vetiveryl acetate, and mixtures thereof.

[0091] In various embodiments, the hydrophobic flavoring agent may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the hydrophobic antimicrobial agent may be from about 0.15% to about 4%, from about 0.18% to about 3.0%, or from about 0.2% to about 2.5% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the flavoring agent relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one hydrophobic flavoring agent. The values ​​given herein refer to the sum of the hydrophobic flavoring agents in the oral care composition.

[0092] In various embodiments, the oral care composition comprises a functional agent, which in turn comprises a medicamentous agent. The medicamentous agent comprises any medicine suitable for medical use. In various embodiments, the medicamentous agent is intended to treat a disease state and / or alleviate the symptoms of a disease state.

[0093] In various embodiments, the pharmaceutically containing agent comprises at least one of menthol, eugenol, camphor, capsicum, thymol, eucalyptol, alcohol, methyl salicylate, sodium fluoride, stannous fluoride, sodium monofluorophosphate, strontium chloride, potassium nitrate, cetylpyridinium chloride, hydrogen peroxide, urea peroxide, sodium citrate, alum, benzocaine, benzyl alcohol, elm bark, glycerin, hexazorine, pectin, phenol, sodium phenolate, salicylol, sodium bicarbonate, sodium perborate, zinc chloride, chlorophyll, citric acid, beech wood, cresol, horehound, lidocaine, myrrh oil, sodium borate, sodium citrate, and / or toluene. In various embodiments, the pharmaceutically containing agent is soluble in fractionated MCT oil.

[0094] In various embodiments, the pharmaceutical agent may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the pharmaceutical agent may be from about 0.15% to about 4%, from about 0.18% to about 3.0%, or from about 0.2% to about 2.5% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the pharmaceutical agent relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one pharmaceutical agent. The values ​​given herein refer to the total amount of pharmaceutical agents in the oral care composition.

[0095] In various embodiments, the oral care composition comprises a functional agent, which includes a saliva stimulant. In various embodiments, the saliva stimulant comprises a hydrophobic material capable of evoking a salivary response in mammals. In various embodiments, essential oils (such as plant essential oils) are used as saliva stimulants, for example, cardamom oil, lavender oil, eucalyptus oil, fennel oil, schezwan oil (e.g., light plant oils such as canola oil infused with red chili peppers), globe amaranth oil, menthol oil, and / or combinations thereof.

[0096] In various embodiments, the saliva stimulant may be present in an amount of about 0.01% to about 10% (e.g., about 0.001%, 0.01%, 0.02%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%) of the weight or volume of the oral care composition. In various embodiments, the amount of the flavoring agent may be about 0.005% to about 0.04%, about 0.01% to about 0.1%, or about 0.015% to about 0.5%. For the avoidance of confusion, the values ​​listed herein are weight percentages of the saliva stimulant relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one saliva stimulant. The values ​​given herein refer to the total amount of saliva stimulants in the oral care composition.

[0097] In various embodiments, the oral care composition comprises hydrophobic vitamins. Hydrophobic vitamins can refer to vitamins that are soluble at 25°C in fractionated coconut oil that is substantially free of fatty acids having 12 or more carbon atoms. Hydrophobic vitamins include vitamin E, vitamin A (retinol), beta-carotene, vitamin D (vitamins D2, D3, D4, and D5), and vitamin K (vitamins K1 and K2).

[0098] In various embodiments, the hydrophobic vitamin may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the hydrophobic vitamin may be from about 0.15% to about 1.2%, from about 0.18% to about 1.0%, or from about 0.2% to about 0.7% by weight of the oral care composition. To avoid confusion, the values ​​listed herein are weight percentages of the hydrophobic vitamin relative to the total weight of the oral care composition. It should be noted that various embodiments may contain more than one hydrophobic vitamin. The values ​​given herein refer to the total amount of hydrophobic vitamins in the oral care composition.

[0099] In various embodiments, the oral care composition comprises a coenzyme. Specifically, in various embodiments, the oral care composition comprises a hydrophobic coenzyme. In various embodiments, the oral care composition comprises coenzyme Q10 (CoQ10), coenzyme A, coenzyme F420, coenzyme B, and coenzyme M, etc. In various embodiments, CoQ10 is included for a variety of benefits. CoQ10 is hydrophobic and therefore soluble in the various embodiments disclosed herein. In this regard, given the properties of MCT oil, CoQ10 may effectively contact oral tissues for the reasons described above. CoQ10 has antioxidant properties, which can improve the health of the gums, teeth, and other tissues in the oral cavity.

[0100] In various embodiments, the coenzyme may be present in an amount from about 0.01% to about 10% by weight of the oral care composition (e.g., about 0.01%, 0.1%, 0.2%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%). In various embodiments, the amount of the coenzyme may be from about 0.15% to about 1.2%, from about 0.18% to about 1.0%, or from about 0.2% to about 0.7% by weight of the oral care composition. For the avoidance of confusion, the values ​​listed herein are weight percentages of the coenzyme relative to the total weight of the oral care composition. It should be noted that various embodiments may contain more than one coenzyme. The values ​​given herein refer to the total amount of coenzymes in the oral care composition.

[0101] In various embodiments, the oral care composition comprises a sweetener. Suitable sweeteners are soluble at 25°C in fractionated coconut oil that is substantially free of fatty acids having 12 or more carbon atoms. In various embodiments, the sweetener comprises sucrose, aspartame, acetylsupan, stevia / stevia glycosides, saccharin, saccharin salts (particularly sodium saccharin), sucralose, sodium cyclohexane, and mixtures thereof. In various embodiments, the sweetener is a polyhydroxy alcohol such as xylitol, mannitol, and sorbitol. In various embodiments, the oral care composition is substantially free of polyhydroxy sweeteners such as xylitol, mannitol, and sorbitol. In various embodiments, the sweetener comprises sucrose, stevia, allulose, sucralose, acetylsupan, aspartame, cyclohexane, or saccharin and combinations thereof. In some embodiments, the amount of sweetener may be from about 0.01% to about 0.5% of the weight or volume of the oral care composition, for example, from about 0.01%, 0.02%, 0.05%, 0.1%, 0.2%, 0.3%, 0.4% to about 5.0%. In various embodiments, the amount of sweetener may be from about 0.05% to about 0.5%, from about 0.1% to about 0.2%, from about 0.01% to about 0.5%, or from 0.01% to about 0.2%.

[0102] In various embodiments, the oral care composition includes a carrier. In various embodiments, suitable carriers include those that satisfy various considerations based on compatibility with other ingredients required for efficacy, consumer quality, cost, and contribution to storage stability. In various embodiments, the selected carrier does not significantly reduce the stability of the oral care composition or its efficacy. Examples of suitable carriers include gelling agents, whitening agents, flavoring agents, coloring agents, abrasives, foaming agents, desensitizing agents, dispersants, humectants, analgesics and anesthetics, anti-inflammatory agents, deodorants, antimicrobial agents, anti-plaque agents, antiviral agents, biofilm disruptors, dispersants or inhibitors, cellular redox regulators, antioxidants, cytokine receptor antagonists, tartar removers, fluoride ion sources, hormones, metalloproteinase inhibitors, enzymes, immunostimulants, lipopolysaccharide chelators, tissue growth factors, vitamins and minerals, water, and mixtures thereof.

[0103] In various embodiments, the oral care composition may further comprise one or more additional functional agents. In various embodiments, additional active ingredients may include one or more of the following: fluoride ion sources, antimicrobial agents, analgesic compounds, anti-inflammatory agents, deodorants, anti-plaque agents, antiviral agents, biofilm disruptors, dissipators or inhibitors, hormones, enzymes, metalloproteinase inhibitors, immunostimulants, and anesthetics. In other embodiments, the oral care composition comprises one or more excipients, including any one of abrasives, humectants, thickeners, sweeteners, moisturizers, flavorings, colorants, fillers, and extenders. In various embodiments, application of the oral care compositions disclosed herein can relieve toothache, reduce gingival hypersensitivity, freshen breath (reduce odor), and provide a pleasant taste.

[0104] In all respects, the oral care composition comprises a pharmaceutically acceptable carrier and / or excipient. A pharmaceutically acceptable carrier comprises one or more compatible solid or liquid materials, including diluents or encapsulating substances, suitable for topical application to the human or animal body, and providing user-acceptable physical effects or consumer-friendly performance. The pharmaceutical carrier and / or excipient can be incorporated into the oral care composition without interacting in any way that diminishes the following properties of the compounds therein: consumer-friendly performance, and the safety and efficacy of the composition in treating or preventing anal, ear, vaginal, oral, nasal, eye, genitourinary, foot, and skin disorders or skin or foot diseases, and inflammation and infection of tissues therein. The selection of a pharmaceutically acceptable carrier and / or excipient may depend on the manner in which the composition is introduced into the anus, vagina, ear, oral cavity, nasal cavity, eye, or genitourinary cavity, or on the manner of topical application for foot care and skin care. A pharmaceutically acceptable carrier and / or excipient may depend on secondary considerations such as, but not limited to, consumer-friendly performance, cost, and shelf-life stability.

[0105] In various embodiments, the amount of the pharmaceutically acceptable carrier and / or excipient may be from about 0.01% to about 30% of the weight or volume of the oral care composition, for example, about 0.01%, 0.1%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, or about 10%. In other embodiments, the amount of the pharmaceutically acceptable carrier may be from about 0.01% to about 60%, from about 0.01% to about 30%, or from about 0.01% to about 20%. To avoid confusion, the values ​​listed herein are weight percentages of the pharmaceutically acceptable carrier relative to the total weight of the oral care composition. It should be noted that various embodiments may have more than one pharmaceutically acceptable carrier. The values ​​given herein refer to the sum of pharmaceutically acceptable carriers in the oral care composition.

[0106] In some aspects, the oral care composition further comprises an abrasive. The abrasive can serve as a carrier for an oral care composition intended for specific oral and dermal applications and uses. For example, the abrasive material provides physical friction between the toothbrush and teeth to clean the epidermis, stratum corneum, biofilm, plaque, stains, and tartar, while also contributing to the structure of various embodiments and maintaining the stability of the overall formulation. In some dermal embodiments, the composition may be needed to aid in the exfoliation of skin tissue. In various embodiments, the abrasive material is selected from compositions that do not excessively abrade the skin, enamel, dentin, or other hard or soft tissues. In various embodiments, the abrasive comprises, for example, silica, hydrated silica (including gels and precipitates), insoluble sodium polymetaphosphate, hydrated alumina, calcium carbonate, calcium hydrogen phosphate dihydrate (trade name "dicalcium phosphate"), tricalcium phosphate, calcium polymetaphosphate, sodium bicarbonate, and resinous abrasives. In various embodiments, mixtures of abrasives may also be used.

[0107] In various embodiments, the abrasive is present in an amount of about 0.01% to about 70% (e.g., about 0.01%, 0.1%, 1%, 2%, 5%, 10%, 15%, 20%, 30%, 40%, 50%, or about 70% by weight) of the multi-component composition. In various embodiments, the abrasive may be present in an amount of about 6% to about 70%, about 10% to about 50%, or about 6% to about 70%, or about 20% to about 70%. In various embodiments, nasal or oral sprays, oral or vaginal douches, and non-abrasive gel compositions (such as those for wound healing) may be free of abrasives.

[0108] In some aspects, the oral care composition contains a colorant. Preferably, the colorant does not reduce the consumer-friendly performance of the oral care composition. Coloring makes it easier for the consumer to determine the use and dosage. Certain colors of the composition may be considered unsuitable for certain anal, vaginal, ear, eye, oral, or genitourinary system uses. In various embodiments, the composition is free of colorants. In various embodiments, the colorant includes FD&C Blue No. 1 or titanium dioxide. In various embodiments, the amount of the colorant may be from about 0.01% to about 10% of the weight or volume of the oral care composition, for example, from about 0.01%, 0.1%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 10%. In other embodiments, the amount of the colorant may be from about 0.5% to about 10%, from about 1% to about 10%, or from about 0.01% to about 2%, or from 0.8% to about 1.1%.

[0109] In various embodiments, the oral care composition further comprises one or more humectants. Suitable humectants include those that prevent pastes, gels, and suspensions from hardening or losing their consumer-friendly properties upon exposure to air, add a moist feel and consumer-friendly properties to the composition, and, for specific humectants used in oral applications, impart a desirable sweetness, such as toothpaste compositions. In various embodiments, the humectant comprises a polyhydroxy alcohol, including arabinol, erythritol, glycerin, maltitol, mannitol, sorbitol, and / or xylitol. Polyhydroxy alcohols are generally accepted excipients, and most fall under the Generally Recognized As Safe (GRAS) category in pharmaceuticals, cosmetics, and food. Other compounds that provide a moist texture to suitable formulations may also be used. In various embodiments, sorbitol may be a humectant included in the oral care composition.

[0110] In various embodiments, the humectant may be present in an amount of about 0.001% to about 70% (e.g., about 0.001%, 0.01%, 1%, 2%, 5%, 10%, 20%, 30%, 40%, 50% to about 70%) of the weight or volume of the oral care composition. In other embodiments, the amount of the humectant may be about 1% to about 15%, about 15% to about 55%, or about 25% to about 55%.

[0111] In various embodiments, the oral care composition includes a fluoride ion source. In various embodiments, a fluoride ion source is not present. In various embodiments, the oral care composition includes free fluoride ions or covalently bound fluoride, the latter of which can be hydrolyzed by oral enzymes to produce free fluoride ions. Free fluoride ions include sodium fluoride, silver diamine fluoride, stannous fluoride, or indium fluoride. Covalently bound fluoride that can be produced by enzymatic hydrolysis can be provided by sodium monofluorophosphate. In various embodiments, sodium fluoride may be included in the oral care composition as a source of free fluoride ions.

[0112] In various embodiments, the oral care composition further comprises a fluoride ion source providing fluoride ions at a concentration of about 0 ppm to about 5000 ppm, or about 50 ppm to about 3500 ppm, or about 500 ppm to about 3500 ppm. In various embodiments, the amount of the fluoride ion source may be about 0% to about 2.0% of the weight or volume of the oral care composition, for example, about 0.01%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8% to about 2.0%. In other embodiments, the amount of the fluoride ion source may be about 0.0% to about 0.03%, about 0.0% to about 0.7%, about 0.1% to about 0.8%, about 0.01% to about 0.07%, or about 0.0% to about 0.8%. When the fluoride ion source is 0% or substantially free of the fluoride described herein, the composition is referred to as a fluoride-free composition.

[0113] In some aspects, oral care compositions further comprise thickeners or binders. Thickeners or binders can provide desired consumer-friendly properties suitable for oral care compositions, such as the required consistency or viscosity of the composition to provide the desired dosage and adhere to hard or soft tissues in topical application. Examples of thickeners or binders include carboxyvinyl polymers, seaweed derivatives (such as carrageenan), hydroxyethyl cellulose, diatomaceous earth, powdered polyethylene, and cellulose ether salts (such as sodium carboxymethyl cellulose and sodium carboxymethyl hydroxyethyl cellulose). Natural gums such as gum arabic, guar gum, xanthan gum, gum arabic, and tragacanth gum can also be used. Colloidal magnesium aluminum silicate or finely pulverized silica can be used as part of the thickener or binder to further improve the texture. Higher concentrations of thickeners can be used in chewing gum, lozenges (including breath fresheners), capsules, non-abrasive gels, and gels for wound healing, vaginal or oral diseases. In various embodiments, for example, the various mouthwash or rinse formulations of the currently disclosed oral care compositions do not contain thickeners or binders. In fact, all currently available oral care compositions, including mouthwashes and rinses, have relatively low viscosity.

[0114] In various embodiments, the thickener or binder may be present in an amount of about 0% to about 15% (e.g., about 0.01%, 0.1%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% to about 15%) of the weight or volume of the oral care composition. In various embodiments, the amount of the thickener or binder may be about 0.1% to about 15%, about 2.0% to about 10%, about 4% to about 8%, about 1.0% to about 4.0%, or about 5.0% to about 7.0%.

[0115] In various embodiments, the oral care composition further comprises a desensitizing agent. The desensitizing agent can be used to provide temporary pain relief to hard or soft tissues. In various embodiments, the desensitizing agent comprises compounds such as strontium chloride, strontium acetate, arginine, hydroxyapatite, nano-hydroxyapatite (nano-HAp), sodium calcium phosphosilicate, potassium chloride, or potassium nitrate. In various embodiments, the composition may be substantially free of compounds that irritate sensitive body cavities (such as the anus, vagina, nasal cavity, eyes, oral cavity, and genitourinary tract), such as sodium lauryl sulfate. Examples of oral allergies and the diseases they cause include aphthous ulcers, stomatitis, and dry mouth.

[0116] In various embodiments, the oral care composition further comprises a preservative. In some embodiments, the preservative comprises methylparaben, propylparaben, disodium EDTA, benzyl alcohol, benzoic acid, or sodium benzoate. In various embodiments, the preservative may be present in an amount of about 0% to about 2% (e.g., 0.01%, 0.1%, 1%, or 2%) of the weight or volume of the oral care composition. In other embodiments, the amount of the surfactant may be about 0.1% to about 0.15%, about 0.2% to about 1%, about 0.01% to 0.5%, or about 0.4% to about 0.8%.

[0117] In various embodiments, the oral care composition may be specifically formulated for human and animal use, for example in the form of mouthwash, gel, paste, cream, lotion, spray, lozenge, therapeutic floss, tape, patch, dressing, or strip, for skin care, oral care, genitourinary care, foot care, wound healing, and as a solution for use in rinsing devices for the oral cavity and other body cavities.

[0118] In various embodiments, the cloud point of the oral care composition is less than -5°C. In various embodiments, the viscosity of the oral care composition is 0-40 cp.

[0119] In various embodiments, the oral care compositions are suitable for a wide range of indications, including the treatment and prevention of oral or vaginal odor, as well as eye, anal, nasal, and skin care and other topical uses. Suitable topical indications include conditions and diseases of the anus, ears, mouth, nose, eyes, genitourinary system, foot care, and skin care. The oral care compositions may be suitable for selected indications, including antimicrobial, bactericidal, antioxidant, bactericidal and bacteriostatic, biofilm penetration, biofilm dissipation and reduction, coagulation, deodorization, desensitization, disinfection, fungicide and fungicidal, herbicidal, tissue damage reduction, bleaching, stain removal, and teeth whitening. The compositions described herein are suitable for use in a variety of forms, including rinses, gels, pastes, creams, lotions, sprays, lozenges, dental floss, tapes, patches, bandages, dressings, dressings, and strips.

[0120] Exemplary Composition I: Oil Pulling

[0121] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a saliva stimulant, and 0.01% to 5% by weight of a vitamin.

[0122] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, from about 10% to about 99%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.01% to 15% peppermint oil, 0.01% to 5% stevia, 0.01% to 15% spearmint oil, 0.01% to 15% clove oil, and total oral care composition weight. The oral care composition contains 0.01% to 15% by weight of tea tree oil, 0.01% to 15% by weight of cardamom oil, 0.01% to 15% by weight of oregano oil, 0.01% to 15% by weight of fennel oil, 0.01% to 5% by weight of vitamin E, 0.01% to 15% by weight of vitamin D3, and 0.01% to 15% by weight of vitamin K2 oil.

[0123] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, of about 85% to about 96%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 3% to 5% peppermint oil by weight of the total oral care composition, 0.01% to 0.09% stevia by weight of the total oral care composition, 0.01% to 0.02% spearmint oil by weight of the total oral care composition, 0.01% to 0.15% clove oil by weight of the total oral care composition, and the total oral care composition... 0.01% to 0.2% by weight of tea tree oil, 0.01% to 0.2% by weight of cardamom oil, 0.01% to 0.1% by weight of oregano oil, 0.01% to 0.05% by weight of fennel oil, 0.01% to 0.1% by weight of vitamin E, 0.001% to 0.003% by weight of vitamin D3, and 0.0001% to 0.01% by weight of vitamin K2 oil.

[0124] Exemplary Composition II: Oil Pulling

[0125] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides substantially does not contain and / or substantially does not contain fatty acids having more than 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, lauric acid and various mixtures thereof, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a saliva stimulant, and 0.01% to 5% by weight of a vitamin.

[0126] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, from about 10% to about 99%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having more than 12 carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, lauric acid, and various mixtures thereof; 0.01% to 15% of peppermint oil by weight of the total oral care composition; 0.01% to 5% of stevia by weight of the total oral care composition; 0.01% to 15% of spearmint oil by weight of the total oral care composition; and 0.01% to 15% of clove oil by weight of the total oral care composition. The oral care composition contains 0.01% to 15% by weight of tea tree oil, 0.01% to 15% by weight of cardamom oil, 0.01% to 15% by weight of oregano oil, 0.01% to 15% by weight of fennel oil, 0.01% to 5% by weight of vitamin E, 0.01% to 15% by weight of vitamin D3, and 0.01% to 15% by weight of vitamin K2 oil.

[0127] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, of about 85% to about 96%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having more than 12 carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having more than 12 carbon atoms and comprises at least one of capric acid, caprylic acid, lauric acid, and various mixtures thereof, 3% to 5% peppermint oil by weight of the total oral care composition, 0.01% to 0.09% stevia by weight of the total oral care composition, 0.01% to 0.02% spearmint oil by weight of the total oral care composition, 0.01% to 0.15% clove oil by weight of the total oral care composition, and the total oral care composition... The oral care composition contains 0.01% to 0.2% tea tree oil, 0.01% to 0.2% cardamom oil, 0.01% to 0.1% oregano oil, 0.01% to 0.05% fennel oil, 0.01% to 0.1% vitamin E, 0.001% to 0.003% vitamin D3, and 0.0001% to 0.01% vitamin K2 oil.

[0128] Exemplary Composition III: Oil Pulling

[0129] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a hydrophobic herbal extract, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0130] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: decanoic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a hydrophobic herbal extract, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0131] Various oral care compositions may comprise: about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: caprylic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a hydrophobic herbal extract, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0132] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: hexanoic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a hydrophobic herbal extract, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0133] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: caproic acid and lauric acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a hydrophobic herbal extract, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0134] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, of about 96% to about 97%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.01% to 0.1% stevia by weight of the total oral care composition, 0.1% to 0.2% clove oil by weight of the total oral care composition, 0.1% to 0.2% tea tree oil by weight of the total oral care composition, 0.1% to 0.2% cardamom oil by weight of the total oral care composition, 0.04% to 0.06% oregano oil by weight of the total oral care composition, and 0.1% to 0.03% galangal by weight of the total oral care composition. The oral care composition contains: a non-ashwagandha hydrophobic extract, 0.01% to 0.2% of the total oral care composition by weight of turmeric root hydrophobic extract, 0.0001% to 0.002% of the total oral care composition by weight of neem hydrophobic extract, 0.09% to 0.1% of the total oral care composition by weight of Roman chamomile hydrophobic extract, 1% to 3% of the total oral care composition by weight of cinnamon bark hydrophobic extract, 0.001% to 0.003% of the total oral care composition by weight of vitamin D3, 0.001% to 0.003% of the total oral care composition by weight of vitamin K2 oil, and 0.05% to 0.1% of the total oral care composition by weight of vitamin E oil.

[0135] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: decanoic acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 0.1% to 0.2% clove oil by weight of the total oral care composition, 0.1% to 0.2% tea tree oil by weight of the total oral care composition, 0.1% to 0.2% cardamom oil by weight of the total oral care composition, 0.04% to 0.06% oregano oil by weight of the total oral care composition, 0.1% to 0.03% hydrophobic extract of Ashwagandha by weight of the total oral care composition, and the total oral care composition. The oral care composition contains 0.01% to 0.2% by weight of turmeric root hydrophobic extract, 0.0001% to 0.002% by weight of neem hydrophobic extract, 0.09% to 0.1% by weight of Roman chamomile hydrophobic extract, 1% to 3% by weight of cinnamon bark hydrophobic extract, 0.001% to 0.003% by weight of vitamin D3, 0.001% to 0.003% by weight of vitamin K2 oil, and 0.05% to 0.1% by weight of vitamin E oil.

[0136] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: caprylic acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 0.1% to 0.2% clove oil by weight of the total oral care composition, 0.1% to 0.2% tea tree oil by weight of the total oral care composition, 0.1% to 0.2% cardamom oil by weight of the total oral care composition, 0.04% to 0.06% oregano oil by weight of the total oral care composition, 0.1% to 0.03% hydrophobic extract of Ashwagandha by weight of the total oral care composition, and the total oral care composition. The oral care composition contains 0.01% to 0.2% by weight of turmeric root hydrophobic extract, 0.0001% to 0.002% by weight of neem hydrophobic extract, 0.09% to 0.1% by weight of Roman chamomile hydrophobic extract, 1% to 3% by weight of cinnamon bark hydrophobic extract, 0.001% to 0.003% by weight of vitamin D3, 0.001% to 0.003% by weight of vitamin K2 oil, and 0.05% to 0.1% by weight of vitamin E oil.

[0137] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: hexanoic acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 0.1% to 0.2% clove oil by weight of the total oral care composition, 0.1% to 0.2% tea tree oil by weight of the total oral care composition, 0.1% to 0.2% cardamom oil by weight of the total oral care composition, 0.04% to 0.06% oregano oil by weight of the total oral care composition, 0.1% to 0.03% hydrophobic extract of Ashwagandha by weight of the total oral care composition, and the total oral care composition. The oral care composition contains 0.01% to 0.2% by weight of turmeric root hydrophobic extract, 0.0001% to 0.002% by weight of neem hydrophobic extract, 0.09% to 0.1% by weight of Roman chamomile hydrophobic extract, 1% to 3% by weight of cinnamon bark hydrophobic extract, 0.001% to 0.003% by weight of vitamin D3, 0.001% to 0.003% by weight of vitamin K2 oil, and 0.05% to 0.1% by weight of vitamin E oil.

[0138] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: hexanoic acid and lauric acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 0.1% to 0.2% clove oil by weight of the total oral care composition, 0.1% to 0.2% tea tree oil by weight of the total oral care composition, 0.1% to 0.2% cardamom oil by weight of the total oral care composition, 0.04% to 0.06% oregano oil by weight of the total oral care composition, 0.1% to 0.03% hydrophobic extract of Ashwagandha by weight of the total oral care composition, and the total oral care... The composition contains 0.01% to 0.2% by weight of a hydrophobic extract of turmeric root, 0.0001% to 0.002% by weight of a hydrophobic extract of neem, 0.09% to 0.1% by weight of a hydrophobic extract of Roman chamomile, 1% to 3% by weight of a hydrophobic extract of cinnamon bark, 0.001% to 0.003% by weight of vitamin D3, 0.001% to 0.003% by weight of vitamin K2 oil, and 0.05% to 0.1% by weight of vitamin E oil.

[0139] Exemplary Composition IV: Oil Pulling

[0140] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.01% to 15% by weight of a flavoring agent, 0% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a pharmaceutical ingredient, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0141] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: decanoic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a pharmaceutical agent, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0142] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: caprylic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a pharmaceutical agent, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0143] Various oral care compositions may comprise: about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: hexanoic acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a pharmaceutical agent, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0144] Various oral care compositions may comprise: from about 10% to about 99% by weight of medium-chain triglycerides and / or mixtures of medium-chain triglycerides. In various embodiments, the mixture of medium-chain triglycerides comprises and / or is substantially composed of the following components: caproic acid and lauric acid, 0.01% to 15% by weight of a flavoring agent, 0.01% to 5% by weight of a sweetener, 0.01% to 15% by weight of a hydrophobic antimicrobial agent, 0.01% to 15% by weight of a pharmaceutical agent, and 0.01% to 5% by weight of a hydrophobic vitamin.

[0145] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, by weight, of about 96% to about 97%, said mixture comprising fractionated coconut oil that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms. Alternatively, in various embodiments, said medium-chain triglyceride mixture substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and comprises at least one of capric acid, caprylic acid, and various mixtures thereof, 0.1% to 5% clove oil, 0.1% to 15% peppermint oil, 0.1% to 15% spearmint oil, 0.1% to 15% tea tree oil, and 0.1% to 5% tea tree oil by weight of the total oral care composition. 15% thyme oil, 0.1% to 2% menthol by weight of the total oral care composition, 0.1% to 5% Zanthoxylum Armatum by weight of the total oral care composition, 0.01% to 15% myrrh oil by weight of the total oral care composition, 0.001% to 0.003% vitamin D3 by weight of the total oral care composition, 0.001% to 0.003% vitamin K2 oil by weight of the total oral care composition, and 0.05% to 0.1% vitamin E oil by weight of the total oral care composition.

[0146] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: decanoic acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 1% to 2% clove oil by weight of the total oral care composition, 0.04% to 0.08% peppermint oil by weight of the total oral care composition, 0.04% to 0.08% spearmint oil by weight of the total oral care composition, 0.1% to 15% tea tree oil by weight of the total oral care composition, and 0%... 0.1% to 0.2% thyme oil, 1% to 2% menthol by weight of the total oral care composition, 0.1% to 0.2% Sichuan pepper by weight of the total oral care composition, 0.1% to 0.2% myrrh oil by weight of the total oral care composition, 0.0001% to 0.003% vitamin D3 by weight of the total oral care composition, 0.00001% to 0.0001% vitamin K2 oil by weight of the total oral care composition, and 0.05% to 0.07% vitamin E oil by weight of the total oral care composition.

[0147] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: caprylic acid, 0.01% to 0.1% stevia by weight of the total oral care composition, 1% to 2% clove oil by weight of the total oral care composition, 0.04% to 0.08% peppermint oil by weight of the total oral care composition, 0.04% to 0.08% spearmint oil by weight of the total oral care composition, 0.1% to 15% tea tree oil by weight of the total oral care composition, and 0%... 0.1% to 0.2% thyme oil, 1% to 2% menthol by weight of the total oral care composition, 0.1% to 0.2% Sichuan pepper by weight of the total oral care composition, 0.1% to 0.2% myrrh oil by weight of the total oral care composition, 0.0001% to 0.003% vitamin D3 by weight of the total oral care composition, 0.00001% to 0.0001% vitamin K2 oil by weight of the total oral care composition, and 0.05% to 0.07% vitamin E oil by weight of the total oral care composition.

[0148] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: hexanoic acid, 1% to 2% clove oil by weight of the total oral care composition, 0.04% to 0.08% peppermint oil by weight of the total oral care composition, 0.04% to 0.08% spearmint oil by weight of the total oral care composition, 0.1% to 15% tea tree oil by weight of the total oral care composition, and 0.1% to 0.2% thyme by weight of the total oral care composition. The oral care composition contains 1% to 2% menthol, 0.1% to 0.2% Sichuan pepper, 0.1% to 0.2% myrrh, 0.0001% to 0.003% vitamin D3, 0.00001% to 0.0001% vitamin K2, and 0.05% to 0.07% vitamin E.

[0149] Various oral care compositions may comprise: a mixture of medium-chain triglycerides, weighing approximately 96% to approximately 97% by weight. In other words, in various embodiments, the medium-chain triglyceride mixture comprises and / or is substantially composed of the following components: hexanoic acid and lauric acid, 1% to 2% clove oil by weight of the total oral care composition, 0.04% to 0.08% peppermint oil by weight of the total oral care composition, 0.04% to 0.08% spearmint oil by weight of the total oral care composition, 0.1% to 15% tea tree oil by weight of the total oral care composition, and 0.1% to 0.2% limonene by weight of the total oral care composition. The oral care composition contains: 1% to 2% menthol, 0.1% to 0.2% Sichuan pepper, 0.1% to 0.2% myrrh, 0.0001% to 0.003% vitamin D3, 0.00001% to 0.0001% vitamin K2, and 0.05% to 0.07% vitamin E.

[0150] Method for preparing exemplary compositions

[0151] refer to Figure 1The diagram illustrates a method 100 for preparing oil-pulled oil. In step 102, a mixture of medium-chain triglycerides that substantially does not contain and / or substantially does not contain fatty acids having 12 or more carbon atoms and includes at least one of capric acid, caprylic acid, and various mixtures thereof, is combined with a hydrophobic antimicrobial agent to obtain a mixture. In step 104, a hydrophobic flavoring agent is added to the mixture to obtain a flavored mixture. In step 106, a hydrophobic pharmaceutical agent is added to the flavored mixture.

[0152] Example 1: Formulation of the oil-pulling scheme

[0153] Various compositions of Exemplary Composition I were formulated and tested below. Table 1 summarizes the tested oil-pull compositions and their components (oils A to H). Oil-pull is a preparation in a single-phase liquid form that needs to be stirred in the mouth for 2 to 10 minutes and then expelled from the mouth.

[0154] Table 1: Oil Pulling

[0155]

[0156] Table 2: Oil Pulling

[0157]

[0158] Table 3: Oil Pulling

[0159]

[0160] Table 4: Oil Pulling

[0161]

[0162] To avoid confusion, the hydrophobic herbal extracts listed in Table 4 may comprise supercritical carbon dioxide extracted oils, extracts prepared using organic solvents, and / or combinations thereof. In various embodiments, only supercritical carbon dioxide extracted oils are used. Exemplary formulations of oil AA are given in Table 5 below.

[0163] Table 5: Oil Pulling

[0164] Table 5 explains various implementation schemes of this disclosure that contain pharmaceutical ingredients.

[0165]

[0166] Table 6: Oil Pulling

[0167] Table 6 explains various implementation schemes of this disclosure that contain pharmaceutical ingredients.

[0168]

[0169] Table 7:

[0170] Table 7 explains the specific implementation schemes of Oil AA in Table 4.

[0171]

[0172] Table 8 below provides other implementation schemes. Table 8 explains the specific implementation scheme of oil AA in Table 4.

[0173] Table 8:

[0174]

[0175] Table 9 below provides other implementation schemes. Table 9 explains the specific implementation scheme of oil AA in Table 4.

[0176] Table 9:

[0177]

[0178] Table 10 below provides other embodiments. These embodiments contain pharmaceutical agents. Table 10 explains specific embodiments of oil AA1 in Table 5.

[0179] Table 10:

[0180]

[0181] Table 11 below provides other embodiments. These embodiments contain pharmaceutical agents. Table 11 explains specific embodiments of oil AA1 in Table 5.

[0182] Table 11:

[0183]

[0184] Table 12 below provides other embodiments. These embodiments contain pharmaceutical agents. Table 12 explains specific embodiments of oil AA1 in Table 5.

[0185] Table 12:

[0186]

[0187] Example 2: Antimicrobial characteristics

[0188] To understand the antimicrobial properties of Oil A in Table 1, a study was conducted. Oil A was used to treat bacteria and compared with a placebo and a commercially available aqueous mouthwash containing ethanol. Tests were performed against Gram-positive and Gram-negative bacteria. Furthermore, tests were conducted related to plaque reduction and improved gingival scores. Results are listed below. Figure 2 and Figure 3 middle.

[0189] Example 3: Odor Effectiveness

[0190] To understand the odor resistance properties of oil A in Table 1, a study was conducted.

[0191] A randomized, double-blind clinical trial was conducted. Sixty (60) adult male and female volunteers were recruited, with oral odor scores of at least 7.0 ± 0.5 on the preference scale. At baseline, preference breath was assessed by three uninformed and calibrated sensory evaluators. Sixty participants who met the continuing criteria (30 in group A and 30 in group B) were randomized. Participants were instructed to avoid alcohol, sulfur-containing foods (such as garlic or onions), use of fragrance cosmetics, smoking, or use of any tobacco products within 12 hours prior to their visit; to avoid taking medicated tablets, mints, candies, or chewing gum containing antimicrobial agents (including, but not limited to, xylitol, essential oils, cetylpyridinium chloride, chlorine dioxide, and zinc) within 24 hours prior to their visit; and to avoid using antibiotics and any other mouthwashes.

[0192] Baseline odor scales were measured at the initial visit. Participants were instructed to use mouthwash A, stirring 10 mL in their mouths for two minutes. Odor was measured again 12 hours after rinsing. Participants then used the mouthwash once daily, stirring for two minutes in their mouths, for three weeks. Odor was then measured again for all participants. All 60 participants completed the study.

[0193] The results show Figure 2 and 3 In contrast to the placebo group (Group A), the active agent group (Group B) showed a significant reduction in halitosis.

[0194] Example 4: Skin Whitening Research

[0195] Thirty healthy volunteers were recruited in a single-arm study. Male and female volunteers with yellowed teeth were also recruited. Changes in tooth color and oral examinations were assessed at baseline and at a 6-week follow-up.

[0196] Before evaluation using the classic Vita shade guide, participants were instructed to perform routine oral hygiene. The color of the labial surfaces of the four maxillary front teeth was recorded using the Vita shade guide. Participants were reminded to use the oral hygiene product (Oil A in Table 1) distributed at baseline. The study lasted six weeks and included one baseline follow-up and one follow-up at the end of the six weeks.

[0197] Participants invited to participate in baseline follow-up were advised to avoid the following for six weeks: coffee, tea, coloring foods, antibiotics, any teeth whitening products, and any other mouthwash.

[0198] The soft tissues of the oral cavity are evaluated by a licensed California dentist using standard dental lights, dental mirrors, and gauze through visual examination of the oral cavity and perioral region. Structures examined include the gingiva (free and attached), hard and soft palate, oropharynx / uvula, buccal mucosa, tongue, floor of mouth, labial mucosa, buccal / labial mucosal folds, lips, and perioral region. The hard tissues of the oral cavity are evaluated by visual examination of teeth and restorations using standard dental lights, dental mirrors, and air guns.

[0199] All participants had teeth rated A1 or higher on the Vita scale. Participants were instructed to use 10 mL of oil A mouthwash (Table 1) once daily, stirring the mouthwash in their mouths for two minutes. Participants returned after six weeks for examination. The mean tooth color change for the samples was 2.6. See below for more data. Figure 4 and 7 .

[0200] The detailed description illustrates embodiments as examples, including best practices. While these embodiments have been described in sufficient detail to enable those skilled in the art to practice the principles of this disclosure, it should be understood that other embodiments can be implemented and chemical changes can be made without departing from the spirit and scope of the principles of this disclosure. Therefore, the detailed description herein is presented for illustrative purposes only and not for limiting purposes. For procedures, methods, techniques, and workflows conforming to certain embodiments, certain operations in the procedures, methods, techniques, and workflows disclosed herein may be combined, and / or the order of certain operations may be changed. For example, the steps listed in any method description may be performed in any suitable order and are not limited to the given order.

[0201] In the above description, all cited references are incorporated herein by reference in their entirety. The citation of any reference does not imply an admission that such reference is relevant prior art; rather, it is used to illustrate the novelty of the inventions and discoveries described herein relative to known scientific literature, practices, and prior art. Unless otherwise specified, all ratios in the description of this disclosure are weight ratios. Unless otherwise indicated or apparent from the context, the preferences set forth above and herein apply to all embodiments discussed herein.

[0202] In describing this disclosure, the following terms will be used: the singular forms “a,” “an,” and “described” include plural indicators unless the context clearly indicates otherwise. Thus, for example, a reference to an article includes a reference to one or more articles. The term “ones” means one, two, or more, and generally applies to a selection of some or all quantities. The term “multiple” means two or more articles. The term “about” means that the quantity, size, size, formulation, parameter, shape, and other characteristics need not be precise, but may be approximated and / or larger or smaller as needed, thereby reflecting acceptable tolerances, conversion factors, rounding, measurement errors, and other factors known to those skilled in the art. The term “substantially” means that the listed features, parameters, or values ​​need not be fully realized, but the amount of deviation or variation (including, for example, tolerances, measurement errors, measurement accuracy limitations, and other factors known to those skilled in the art) will not prevent the effect that the feature is intended to provide.

[0203] Numerical data in this document may be represented or presented in a range format. It should be understood that such a range format is used solely for convenience and brevity, and therefore should be interpreted flexibly. It includes not only the values ​​explicitly listed as range boundaries, but also all individual values ​​or subranges covered within that range, as if each value and subrange were explicitly listed. For example, the numerical range “about 1 to 5” should be interpreted as including not only the explicitly listed values ​​of about 1 to about 5, but also the individual values ​​and subranges within the indicated range. Therefore, this numerical range includes individual values ​​such as 2, 3, and 4, as well as subranges such as 1-3, 2-4, and 3-5.

[0204] This same principle applies to ranges describing only a single numerical value (e.g., "greater than about 1"), and should apply regardless of the breadth of the range or the characteristics described. For convenience, multiple items may be listed in the same list. However, these lists should be interpreted as if each member of the list were individually identified as a separate and distinct member. Therefore, a single member of such a list should not be interpreted, without the contrary indication, solely based on its presentation in a common group as a de facto equivalent to any other member of the same list. Furthermore, when the terms "and" and "or" are used with a series of items, they should be interpreted broadly, meaning that any one or more of the listed items can be used alone or in combination with other listed items. The term "alternatively" indicates selection from two or more alternatives and is not intended to limit the selection to those listed alternatives, or to select only one of the listed alternatives at a time, unless the context clearly indicates otherwise.

[0205] The scope of protection should be determined by the appended claims and their legal equivalents, not by the embodiments given above. For example, the operations listed in any method claim may be performed in any order, and are not limited to the order presented in the claims. Furthermore, no element is required unless expressly described herein as "critical" or "essential".

[0206] Furthermore, when phrases such as "at least one of A, B, and C" or "at least one of A, B, or C" are used in the claims or specification, such phrases should be interpreted as meaning that A may exist alone in one embodiment, B may exist alone in one embodiment, C may exist alone in one embodiment, or any combination of elements A, B, and C may exist in one embodiment; for example, A and B, A and C, B and C, or A and B and C.

Claims

1. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides comprising approximately 85% to approximately 96% by weight, the mixture substantially free of fatty acids having 12 or more carbon atoms and containing at least one of capric or octanoic acid. The oral care composition contains 0.01% to 0.2% cardamom oil by weight; The oral care composition contains 0.01% to 0.1% oregano oil by weight; and The oral care composition contains 0.01% to 0.05% fennel oil by weight.

2. The oral care composition for oral care according to claim 1, further comprising 0.01% to 0.09% stevia by weight of the oral care composition.

3. The oral care composition for oral care according to claim 2, further comprising 3% to 5% peppermint oil by weight of the oral care composition.

4. The oral care composition for oral care according to claim 3, further comprising 0.01% to 0.2% spearmint oil by weight of the oral care composition.

5. The oral care composition for oral care according to claim 4, further comprising 0.01% to 0.15% clove oil by weight of the oral care composition.

6. The oral care composition for oral care according to claim 5, further comprising 0.01% to 0.2% by weight of tea tree oil in the oral care composition.

7. The oral care composition for oral care according to claim 6, further comprising 0.01% to 0.1% by weight of vitamin E in the oral care composition.

8. The oral care composition for oral care according to claim 7, further comprising 0.001% to 0.003% by weight of vitamin D3 and 0.0001% to 0.01% by weight of vitamin K2 oil of the oral care composition.

9. The oral care composition for oral care according to claim 8, wherein the medium-chain triglyceride mixture comprises decanoic acid and caprylic acid.

10. The oral care composition for oral care according to claim 9, wherein the ratio of decanoic acid to caprylic acid is between 70:30 and 30:

70.

11. The oral care composition for oral care according to claim 8, wherein the medium-chain triglyceride mixture is composed of decanoic acid.

12. The oral care composition for oral care according to claim 8, wherein the medium-chain triglyceride mixture is composed of caprylic acid.

13. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides, comprising approximately 90% to approximately 96% by weight, which substantially does not contain fatty acids having 12 or more carbon atoms and contains at least one of capric or octanoic acid. The oral care composition contains greater than 0% and less than 1% by weight tea tree oil; and The oral care composition contains more than 0% to less than 1% fennel oil by weight.

14. The oral care composition for oral care according to claim 13, further comprising more than 0% to less than 1% stevia by weight of the oral care composition.

15. The oral care composition for oral care according to claim 14, further comprising more than 0% to less than 1% by weight of spearmint oil in the oral care composition.

16. The oral care composition for oral care according to claim 15, further comprising more than 0% to less than 1% by weight of cardamom oil in the oral care composition.

17. The oral care composition for oral care according to claim 16, further comprising more than 0% to less than 1% by weight of oregano oil in the oral care composition.

18. The oral care composition for oral care according to claim 17, further comprising more than 0% to less than 1% clove oil by weight of the oral care composition.

19. The oral care composition for oral care according to claim 18, further comprising 3% to 5% peppermint oil by weight of the oral care composition.

20. The oral care composition for oral care according to claim 19, further comprising: The oral care composition contains more than 0% to less than 1% vitamin E by weight; The oral care composition contains greater than 0% to less than 1% by weight of vitamin D3; and The oral care composition contains more than 0% to less than 1% vitamin K2 oil by weight.

21. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides, comprising approximately 96% to approximately 97% by weight, which substantially does not contain fatty acids having 12 or more carbon atoms and contains at least one of capric or octanoic acid. The oral care composition contains 0.1% to 0.3% by weight of Ashwagandha extract from South Africa; The oral care composition contains 0.001% to 0.002% by weight of neem extract; and The oral care composition contains 0.01% to 0.2% turmeric root extract by weight.

22. The oral care composition for oral care according to claim 21, further comprising 0.1% to 0.09% by weight of Roman chamomile oil of the oral care composition.

23. The oral care composition for oral care according to claim 22, further comprising 0.01% to 0.1% by weight of stevia leaf extract of the oral care composition.

24. The oral care composition for oral care according to claim 23, further comprising 0.04% to 0.06% by weight of oregano oil of the oral care composition.

25. The oral care composition for oral care according to claim 24, further comprising 0.1% to 0.2% clove oil by weight of the oral care composition.

26. The oral care composition for oral care according to claim 25, further comprising 0.1% to 0.2% by weight of tea tree oil in the oral care composition.

27. The oral care composition for oral care according to claim 26, further comprising 0.05% to 0.1% by weight of vitamin E in the oral care composition.

28. The oral care composition for oral care according to claim 27, further comprising 0.001% to 0.003% by weight of vitamin D3 and 0.0001% to 0.0002% by weight of vitamin K2 oil of the oral care composition.

29. The oral care composition for oral care according to claim 28, wherein the medium-chain triglyceride mixture comprises decanoic acid and caprylic acid.

30. The oral care composition for oral care according to claim 29, wherein the Ashwagandha extract, Neem extract, and Turmeric root extract comprise Ashwagandha extract extracted with supercritical carbon dioxide, Neem extract extracted with supercritical carbon dioxide, and Turmeric root extract extracted with supercritical carbon dioxide.

31. The oral care composition for oral care according to claim 28, wherein the medium-chain triglyceride mixture is composed of decanoic acid.

32. The oral care composition for oral care according to claim 28, wherein the medium-chain triglyceride mixture is composed of caprylic acid.

33. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides, comprising approximately 50% to approximately 99% by weight, which substantially does not contain fatty acids having 12 or more carbon atoms and contains at least one of capric or octanoic acid. The oral care composition contains 0.01% to 5% by weight of Ashwagandha extract from South Africa; The oral care composition contains 0.01% to 5% by weight of neem extract; and The oral care composition contains 0.01% to 5% turmeric root extract by weight.

34. The oral care composition for oral care according to claim 33, further comprising 0.01% to 10% by weight of Roman chamomile oil of the oral care composition.

35. The oral care composition for oral care according to claim 34, further comprising 0.01% to 5% by weight of stevia leaf extract of the oral care composition.

36. The oral care composition for oral care according to claim 35, further comprising 0.01% to 15% by weight of oregano oil of the oral care composition.

37. The oral care composition for oral care according to claim 36, further comprising 0.01% to 15% clove oil by weight of the oral care composition.

38. The oral care composition for oral care according to claim 37, further comprising 0.01% to 15% by weight of tea tree oil in the oral care composition.

39. The oral care composition for oral care according to claim 38, further comprising 0.05% to 0.1% by weight of vitamin E in the oral care composition.

40. The oral care composition for oral care according to claim 39, further comprising 0.001% to 1% by weight of vitamin D3 and 0.01% to 1% by weight of vitamin K2 oil of the oral care composition.

41. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides comprising approximately 94% to approximately 96% by weight, the mixture substantially free of fatty acids having 12 or more carbon atoms and containing at least one of capric or octanoic acid. The oral care composition contains 0.5% to 2% menthol by weight; The oral care composition contains 0.001% to 0.2% by weight of bamboo leaf and Sichuan pepper extract; and The oral care composition contains 0.01% to 0.2% myrrh oil by weight.

42. The oral care composition for oral care according to claim 41, further comprising 0.01% to 0.2% by weight of thyme oil in the oral care composition.

43. The oral care composition for oral care according to claim 42, further comprising 0.04% to 0.08% by weight of spearmint oil in the oral care composition.

44. The oral care composition for oral care according to claim 43, further comprising 0.01% to 0.08% peppermint oil by weight of the oral care composition.

45. The oral care composition for oral care according to claim 44, further comprising 0.5% to 2% clove oil by weight of the oral care composition.

46. ​​The oral care composition for oral care according to claim 45, further comprising 0.01% to 0.2% by weight of tea tree oil in the oral care composition.

47. The oral care composition for oral care according to claim 46, further comprising 0.05% to 0.07% by weight of vitamin E in the oral care composition.

48. The oral care composition for oral care according to claim 47, further comprising 0.001% to 0.003% by weight of vitamin D3 and 0.00001% to 0.0001% by weight of vitamin K2 oil of the oral care composition.

49. The oral care composition for oral care according to claim 48, wherein the medium-chain triglyceride mixture comprises decanoic acid and caprylic acid.

50. The oral care composition for oral care according to claim 49, wherein the ratio of decanoic acid to caprylic acid is between 70:30 and 30:

70.

51. The oral care composition for oral care according to claim 48, wherein the medium-chain triglyceride mixture is composed of decanoic acid.

52. The oral care composition for oral care according to claim 48, wherein the medium-chain triglyceride mixture is composed of caprylic acid.

53. An oral care composition for oral care, comprising: A mixture of medium-chain triglycerides comprising approximately 10% to approximately 99% by weight, the mixture substantially free of fatty acids having 12 or more carbon atoms and containing at least one of capric or octanoic acid. The oral care composition contains 0.01% to 2% menthol by weight; The oral care composition contains 0.01% to 5% by weight of Sichuan pepper; and The oral care composition contains 0.01% to 15% myrrh oil by weight.

54. The oral care composition for oral care according to claim 53, further comprising 0.1% to 15% by weight of thyme oil in the oral care composition.

55. The oral care composition for oral care according to claim 54, further comprising 0.1% to 15% by weight of peppermint oil in the oral care composition.

56. The oral care composition for oral care according to claim 55, further comprising 0.1% to 15% by weight of spearmint oil in the oral care composition.

57. The oral care composition for oral care according to claim 56, further comprising 0.1% to 5% clove oil by weight of the oral care composition.

58. The oral care composition for oral care according to claim 57, further comprising 0.1% to 15% by weight of tea tree oil in the oral care composition.

59. The oral care composition for oral care according to claim 58, further comprising 0.1% to 5% by weight of vitamin E in the oral care composition.

60. The oral care composition for oral care according to claim 59, further comprising 0.1% to 1% by weight of vitamin D3 and 0.1% to 1% by weight of vitamin K2 oil of the oral care composition.

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