Colorants for siliconizing syringes

Abstract

The present invention relates generally to a colored oil comprising a combination of at least one oil (e.g., one or more silicone oils and / or one or more hydrocarbon oils) and at least one coloring compound selected from one or more fluorescent compositions (e.g., one or more acrylic fluorescent compositions and / or one or more ultraviolet dyes).

Description

Cross-references to related applications

[0001] This application claims priority to European patent application No. 24156141.4, filed on February 6, 2024, entitled "Colorant for Siliconization of Syringes", the disclosure of which is incorporated herein by reference in its entirety.

[0002] Background of the Invention Field of the Invention The present invention generally relates to a coloring oil comprising a combination of at least one oil (e.g., one or more silicone oils and / or one or more hydrocarbon oils) and at least one coloring compound selected from one or more fluorescent compositions (e.g., one or more acrylic fluorescent compositions and / or one or more ultraviolet dyes). In one embodiment, the present invention relates to a coloring oil comprising a combination of at least one oil and at least one coloring compound, wherein the oil is selected from one or more silicone oils, one or more hydrocarbon oils, or any two or more of them, wherein the viscosity of the at least one oil is in the range of about 500 centipoise to about 1500 centipoise, and the coloring compound is selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more of them, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0003] Description of related technologies Some devices require slow and controlled initiation and maintenance of sliding movement between two surfaces. It is well known that two stationary surfaces in a sliding relationship typically exhibit sufficient resistance to the initiation of movement so that gradually increasing forces applied to one surface do not induce movement until a threshold force is reached, at which point the surfaces undergo a sudden sliding or shear separation. This sudden separation of stationary surfaces into a sliding relationship is referred to herein as “breakout” or “breakloose”.

[0004] "Breakout force" refers to the force required to overcome the static friction between the surfaces of a syringe assembly that was previously moving in a sliding relationship but has remained stationary ("parked") for a short period of time (e.g., milliseconds to hours). A less well-known but important frictional force is "breakloose force," which refers to the force required to overcome the static friction between the surfaces of a syringe assembly that was not previously moving in a sliding relationship or has been stationary for a longer period of time, typically due to chemical or material bonding or surface deformation caused by aging, sterilization, temperature cycling, or other treatments.

[0005] In liquid dispensing devices (e.g., syringes) used to deliver small, precisely metered amounts of liquid via a linear advance that smoothly increases from one surface to the second, the starting and releasing forces are particularly cumbersome. This problem also arises in devices using stopcock valves (e.g., burettes, pipettes, feeding funnels, etc.), where careful drop-by-drop flow control is required.

[0006] Problems of excessive starting and releasing forces are related to friction. Friction is generally defined as the resistance that arises when the surface of one material slides or tends to slide on its own or on an adjacent surface of another material. Between contacting solid surfaces, there may be two types of friction: (1) the resistance to the force required to initiate movement from one surface to another, usually called static friction; and (2) the resistance to the force required to move from one surface to another at a variable, fixed, or predetermined speed, usually called kinetic friction.

[0007] The forces required to overcome static friction and to initiate or loosen the motion are respectively called "starting force" or "loosening force," and the force required to maintain stable sliding of one surface on another after initiation or loosening is called "holding force." Static friction is generated by two main factors: viscosity and inertia, which in turn generate starting or loosening forces. The terms "adhesion" or "viscosity" as used herein refer to the tendency of two statically contacting surfaces to develop a degree of mutual adhesion. The term "inertia" is generally defined as the maladaptive tendency to motion that must be overcome to make an object move. In the context of this invention, inertia is understood to refer to the component of the starting or loosening force that does not involve adhesion.

[0008] The initiation or release force, and especially the degree of adhesion, varies depending on the surface composition. Generally, elastic materials exhibit greater adhesion than inelastic materials. The length of time that surfaces remain in contact with each other also affects the initiation and / or release force. In the syringe industry, the term "dwell time" refers to the storage time, retention time, or interval between filling and dispensing. Dwell time typically increases the initiation or release force, especially if the syringe is refrigerated or heated during the dwell time.

[0009] A common method to overcome starting or loosening is to apply a lubricant to the surface-to-surface interface. Commonly used lubricants are hydrocarbon oils, such as mineral oil, peanut oil, and vegetable oil. A disadvantage of these products is their solubility in various fluids, making them suitable for applications such as drug carriers. Furthermore, these lubricants are susceptible to oxidation by air, leading to changes in viscosity and undesirable color. They are also particularly prone to migrating from the surface to the surface interface. This lubricant migration is often attributed to the increase in starting or loosening force over time during parking.

[0010] Given the above, silicone oil is typically applied to syringes to achieve the aforementioned benefits. The silicone coating can be deposited on the inner wall of the syringe barrel by spraying, dipping, or other suitable application techniques. After application, the silicone coating is usually treated to prevent interaction with the components of the drug or agent contained within the syringe barrel. For example, for silicone coatings containing poly(dimethylsiloxane) emulsions, the coating is typically annealed to form a so-called "baked silicone," making the coating less reactive with the drug / agent contained in the syringe barrel.

[0011] While silicone oils and various hydrocarbon oils provide adequate lubrication within syringes, it should be recognized that these oils may not be well detected under various conditions. For example, silicone oils may not be well detected when low layer thicknesses are present (such as in the case of baked silicone), which can make it difficult to determine the uniformity of the layer and the presence of any pores in the silicone or hydrocarbon oil coating applied to / to the glass syringe barrel (e.g., a Neopak barrel). As another example, silicone oils may not be well detected when rapid detection of silicone or hydrocarbon oils in a syringe barrel (with 4, 5, 6, 7, or even 8 measurement lines along the syringe diameter) is desired. Yet another example: when using conventional silicone oils, detecting X-Si particles in solution relative to other types of particles can be difficult during drug-syringe interaction studies. Finally, silicone oils may not be well detected at the glass-stop interface.

[0012] Therefore, there is a need for an improved oil for medical devices, including but not limited to syringes, that allows for better testing, property determination, and / or quality control based on improved contrast using one or more coloring compounds detailed herein. In another case, there is a need for improved detection / observation of silicone or hydrocarbon oils to enable faster analysis and understanding of their behavior in syringes, medical device stops, AGF testing, etc. Summary of the Invention

[0013] The present invention generally relates to a coloring oil comprising a combination of at least one oil (e.g., one or more silicone oils and / or one or more hydrocarbon oils) and at least one coloring compound selected from one or more fluorescent compositions (e.g., one or more acrylic fluorescent compositions and / or one or more ultraviolet dyes). In one embodiment, the present invention relates to a coloring oil comprising a combination of at least one oil and at least one coloring compound, wherein the oil is selected from one or more silicone oils, one or more hydrocarbon oils, or any two or more of them, wherein the viscosity of the at least one oil is in the range of about 500 centipoise to about 1500 centipoise, and the coloring compound is selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more of them, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0014] According to one aspect, the present invention relates to a coloring oil comprising at least one oil selected from one or more silicone oils, one or more hydrocarbon oils, or any combination of two or more thereof, wherein the viscosity of the at least one oil is in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0015] In another embodiment, the present invention relates to a coloring silicone oil comprising at least one silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0016] In yet another embodiment, the present invention relates to a method for calibrating and detecting colored silicone oil in a syringe barrel, the method comprising the steps of: (a) providing a syringe barrel with a colored silicone oil coated on its inner surface; (b) obtaining an image of the inner surface of the syringe barrel coated with the colored silicone oil using an imaging system, wherein the imaging system is capable of detecting the colored silicone oil; and (c) determining, based on the image obtained from step (b), how the colored silicone oil interacts with at least one internal feature present in the syringe barrel.

[0017] In another aspect, the present invention relates to a syringe comprising at least one oil composition according to any of the embodiments disclosed herein.

[0018] Article 1: A coloring oil comprising: at least one oil selected from one or more silicone oils, one or more hydrocarbon oils, or any combination of two or more thereof, wherein the viscosity of the at least one oil is in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0019] Article 2: The coloring oil according to Article 1, wherein the at least one oil is selected from at least one silicone oil.

[0020] Article 3: Coloring oil according to any one of Article 1 or Article 2, wherein the at least one oil is selected from at least one silicone oil with a viscosity of about 1000 centipoise.

[0021] Article 4: A coloring oil according to any one of Articles 1 to 3, wherein the coloring oil comprises about 0.1 vol% to about 3 vol% of the at least one coloring compound per 100 vol% of the coloring oil.

[0022] Article 5: A coloring oil according to any one of Articles 1 to 4, wherein the coloring oil comprises about 0.25 vol% to about 2.5 vol% of the at least one coloring compound per 100 vol% of the coloring oil.

[0023] Article 6: A coloring oil according to any one of Articles 1 to 5, wherein the coloring oil comprises about 0.5 vol% to about 2 vol% of the at least one coloring compound per 100 vol% of the coloring oil.

[0024] Article 7: A coloring oil according to any one of Articles 1 to 6, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

[0025] Article 8: A coloring oil according to any one of Articles 1 to 7, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

[0026] Article 9: A coloring silicone oil comprising: at least one silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0027] Article 10: The colored silicone oil according to Article 9, wherein the at least one silicone oil has a viscosity of about 1000 centipoise.

[0028] Article 11: A colored silicone oil according to any one of Articles 9 or 10, wherein the colored silicone oil comprises about 0.1 vol% to about 3 vol% of the at least one colored compound per 100 vol% of the colored silicone oil.

[0029] Article 12: A colored silicone oil according to any one of Articles 9 to 11, wherein the colored silicone oil comprises about 0.25 vol% to about 2.5 vol% of the at least one colored compound per 100 vol% of the colored silicone oil.

[0030] Article 13: A colored silicone oil according to any one of Articles 9 to 12, wherein the colored silicone oil comprises about 0.5 vol% to about 2 vol% of the at least one colored compound per 100 vol% of the colored silicone oil.

[0031] Article 14: Colored silicone oil according to any one of Articles 9 to 13, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

[0032] Article 15: Colored silicone oil according to any one of Articles 9 to 14, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

[0033] Article 16: A method for calibrating and detecting colored silicone oil in a syringe barrel, the method comprising the steps of: (a) providing a syringe barrel with a colored silicone oil coated on its inner surface; (b) obtaining an image of the inner surface of the syringe barrel coated with the colored silicone oil using an imaging system, wherein the imaging system is capable of detecting the colored silicone oil; and (c) determining, based on the image obtained from step (b), how the colored silicone oil interacts with at least one internal feature present in the syringe barrel.

[0034] Article 17: The method according to Article 16, wherein the coloring silicone oil comprises: at least one silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more of them, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0035] Article 18: The method according to any one of Articles 16 or 17, wherein the viscosity of the at least one colored silicone oil is about 1000 centipoise.

[0036] Article 19: The method according to any one of Articles 16 to 18, wherein the coloring silicone oil comprises about 0.1 vol% to about 3 vol% of the at least one coloring compound per 100 vol% of the coloring silicone oil.

[0037] Article 20: The method according to any one of Articles 16 to 19, wherein the coloring silicone oil comprises about 0.25 vol% to about 2.5 vol% of the at least one coloring compound per 100 vol% of the coloring silicone oil.

[0038] Article 21: The method according to any one of Articles 16 to 20, wherein the coloring silicone oil comprises about 0.5 vol% to about 2 vol% of the at least one coloring compound per 100 vol% of the coloring silicone oil.

[0039] Article 22: The method according to any one of Articles 16 to 21, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

[0040] Article 23: The method according to any one of Articles 16 to 22, wherein the at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm. Attached Figure Description

[0041] Figure 1This is a perspective view of an exemplary syringe, and various embodiments of this disclosure can be implemented using this syringe; Figure 2 for Figure 1 A three-dimensional view of a syringe, showing the needle cap covering the distal end of the syringe; Figure 3 for Figure 1 A cross-sectional side view of the syringe barrel, showing the application of coloring oil to the inner surface of the barrel according to an embodiment of the invention; Figure 4 According to the non-limiting embodiments, it is possible to... Figure 1 A perspective view of a stop used with syringes; Figure 5 According to another non-limiting embodiment, it can be used with Figure 1 A perspective view of a stop used with syringes; Figure 6 According to another non-limiting embodiment, it can be used with Figure 1 A perspective view of a stop used with syringes; Figure 7 According to another non-limiting embodiment, it can be used with Figure 1 A perspective view of a stop used with syringes; Figure 8 According to another non-limiting embodiment, it can be used with Figure 1 A perspective view of a stop used with a syringe; and Figure 9 According to another non-limiting embodiment, it can be used with Figure 1 A perspective view of a stop used with a syringe. Detailed Implementation

[0042] The following description is provided to enable those skilled in the art to make and use the described embodiments intended for carrying out the invention. However, various modifications, equivalents, variations, and substitutions will be apparent to those skilled in the art. Any and all of these modifications, variations, equivalents, and substitutions are intended to fall within the spirit and scope of the invention.

[0043] In the following text, for descriptive purposes, the terms “upper,” “lower,” “right,” “left,” “vertical,” “horizontal,” “top,” “bottom,” “lateral,” “longitudinal,” and their derivatives shall be used in relation to the orientation of the invention as shown in the accompanying drawings. However, it should be understood that the invention may employ various alternative variations unless explicitly stated otherwise. It should also be understood that the specific devices shown in the accompanying drawings and described in the following specification are merely exemplary embodiments of the invention. Therefore, specific dimensions and other physical features relating to the embodiments disclosed herein should not be considered limiting. As described above, aspects of this disclosure generally relate to a coloring oil comprising a combination of at least one oil (e.g., one or more silicone oils and / or one or more hydrocarbon oils) and at least one coloring compound selected from one or more fluorescent compositions (e.g., one or more acrylic fluorescent compositions and / or one or more ultraviolet dyes). In one embodiment, the invention relates to a coloring oil comprising a combination of at least one oil and at least one coloring compound, wherein the oil is selected from one or more silicone oils, one or more hydrocarbon oils, or any two or more of them, wherein the viscosity of the at least one oil is in the range of about 500 centipoise to about 1500 centipoise, and the coloring compound is selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more of them, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0044] First, an exemplary syringe will be described, wherein at least a portion of the syringe (e.g., the syringe barrel) is made of a suitable glass or plastic material associated with the coloring oil of the present invention. However, it should be noted that the coloring oil of the present invention is not limited to the one or more syringe embodiments described below, but can be broadly applied to any syringe or other medical device requiring one or more visual tests to determine the behavior of one or more materials in and / or on the syringe stop to produce better visual observation results.

[0045] refer to Figures 1 to 3 The diagram illustrates a non-limiting embodiment of syringe 10, which can be used to implement various aspects or embodiments of the present disclosure. According to some aspects of the present disclosure, syringe 10 can be configured as a pre-filled syringe, which provides the convenience of rapidly delivering the liquid therein to a patient without first aspirating the medication from another container and measuring its volume.

[0046] like Figure 1 and Figure 2As shown, syringe 10 typically includes a syringe barrel 12 and a plunger assembly 14. For example, the plunger assembly 14 can be moved along a longitudinal axis within the syringe barrel 12 to a forward position to facilitate the administration of an injectable fluid (e.g., a medication) to a patient. The syringe barrel 12 is formed of a suitable glass or plastic material and includes a generally cylindrical outer wall 16 and an end member 18, which together define a chamber 20 for retaining fluid therein. The syringe barrel 12 includes an open proximal end 22 and a distal end 24, the open proximal end 22 being configured to receive the plunger assembly 14 therein, and the end member 18 being located at the distal end 24. The proximal end 22 of the syringe barrel 12 may include a flange 26 to facilitate manipulation and positioning of the syringe 10 and to maintain the relative position of the syringe barrel 12 with respect to the plunger assembly 14 during medication administration. At the distal end 24, the end member 18 may include a hub 30 that narrows relative to the cylindrical outer wall 16 and extends distally from the cylindrical outer wall. The hub portion 30 is formed as a partially hollow member that defines a passage through which it is in fluid communication with the chamber 20. The needle 34 is attached to the hub portion 30 within the passage, for example by gluing or otherwise securing it to the hub portion 30. According to some aspects of this disclosure, the syringe 10 may also include a cap 35 that is coupled to the hub portion 30 of the syringe barrel 12 to protect the needle 34.

[0047] The plunger assembly 14 of the syringe 10 is formed by an elongated plunger rod 36 (hereinafter more generally referred to as "plunger 36") and a plunger head or stop 38. The plunger 36 may include a body 40 extending between a proximal plunger end 42 and a distal plunger end 44. A thumb press 46 is positioned at the proximal plunger end 42, which can be engaged by a user's thumb (or other finger) to apply a distal force to the plunger assembly 14, thereby moving the plunger 36 relative to the syringe barrel 12. The distal plunger end 44 is configured to mate with the stop 38. In other embodiments, the distal plunger end 44 may be a threaded end that mates with the stop 38.

[0048] The stop 38 of the plunger assembly 14 is positioned at the distal end 44 of the plunger so that it can move with the plunger 36 within the chamber 20 of the syringe barrel 12. That is, when a distal force is applied to the plunger rod 36 (e.g., to the thumb press portion 46), both the plunger rod 36 and the stop 38 are caused to move distally through the syringe barrel 12, wherein the stop 38 is configured to maintain a seal with the inner surface of the syringe barrel 12 as it moves through the syringe barrel 12.

[0049] Now for reference Figures 4 to 9 And continue to refer to Figures 1 to 3According to a non-limiting aspect or embodiment of this disclosure, the structure of various stops 38 that may be included in the syringe 10 is shown in more detail. Each stop 38 is defined by a body 52 including a proximal end 54 and a distal end 56. The proximal end 54 may be configured as an open proximal end engaging the distal end of a plunger 36, while the distal end 56 is configured as a closed distal end engaging the barrel 12 of the syringe 10. The closed distal end 56 of the body 52 includes a generally cylindrical portion 58 and a top 60 extending distally from the cylindrical portion 58. In some embodiments, the top 60 is configured as a conical portion ( Figure 4 , Figure 7 and Figure 9 The conical portion extends distally from the cylindrical portion 58 to the end to provide a closed distal end 56. In other embodiments, as another non-limiting example, the top 60 is formed as a flat surface. Figure 6 and Figure 8 ) or dome surface ( Figure 5 ).

[0050] As is known in the art, the body 52 of the stop 38 is partially hollow and is sized and configured to receive the distal end 44 of the plunger 36 therein. The body 52 of the stop 38 defines an inner cavity (not shown), which in some embodiments may include a threaded inner surface configured to receive and engage with the threaded distal end 44 of the plunger 36. In other embodiments, the cavity may define an inner contoured surface having a recess therein configured to receive a flanged extension of the plunger 36.

[0051] The outer surface 68 of the cylindrical portion 58 of the body 52 includes one or more ribs located thereon, which extend circumferentially around the entire outer surface 68 of the cylindrical portion 58. In each of these illustrated embodiments, the stop 38 includes a plurality of ribs 70; however, it should be appreciated that other embodiments may include only a single rib 70. The ribs 70 may be integrally formed with the body 52, for example, by a molding process. The plurality of ribs 70 may include two ribs 70, wherein a first or distal rib is positioned toward the distal end 56 of the body 52 and a second or proximal rib is positioned toward the proximal end 54 of the body 52, or more ribs may include three or more ribs 70 spaced apart along the cylindrical portion 58, wherein an interrib region 72 is provided between each pair of adjacent ribs. The interrib region 74 of the cylindrical portion 58 may have a generally flat outer surface 68 or a curved outer surface 68.

[0052] The stop 38 may be made of a material different from that of the plunger 36 and capable of forming a tight seal with the syringe barrel 12 as the stop passes through it. In some embodiments, as a non-limiting example, the stop 38 is formed of an elastic or rubber material (e.g., butyl rubber, styrene-butadiene, isoprene). In other embodiments, as a non-limiting example, the stop 38 may alternatively be formed of a polymeric material (e.g., a crosslinked or thermoplastic elastomer).

[0053] According to various aspects of this disclosure, the stop 38 may also include an outer laminate or coating 75 on at least a portion thereof (e.g., on its sealing or sliding surface, i.e., on the contact surface 76 of the first rib 70 and the second rib 72; and / or on the top 60). The laminate / coating 75 may be configured to reduce friction between the stop 38 and the barrel 12 as the stop 38 moves within the syringe 10. According to various aspects of this disclosure, as a non-limiting example, the laminate / coating 75 may be formed from one or more of ultra-high-molecular-weight polyethylene (UHMWPE), liquid silicone rubber (LSR), polydicyclopentadiene (PDCPD), polymethyl urea (PMU), polyvinylidene difluoride (PVDF), polyethylene compounds, polysulfone films, or fluoropolymers. In some embodiments, it may be desirable for the laminate / coating 75 to be formed of a material that is free of or substantially free of per- and poly-fluoroalkyl substances (PFAS).

[0054] In one embodiment, the stop 38 is ideally made of any suitable polymeric material with a Young's modulus (also referred to as tensile modulus, elastic modulus, or traction modulus) in the range of: about 4 MPa to about 9 MPa, or about 4.25 MPa to about 8.75 MPa, or about 4.5 MPa to about 8.5 MPa, or about 4.75 MPa to about 8.25 MPa, or about 5 MPa to about 8 MPa, or about 5.25 MPa to about 7.75 MPa, or about 5.5 MPa to about 7.5 MPa, or about 5.75 MPa to about 7.25 MPa, or about 6 MPa to about 7 MPa, or about 6.25 MPa to about 6.75 MPa; or even made of any suitable polymeric material with a Young's modulus of about 6.5 MPa. In another embodiment, the stop 38 is ideally made of any suitable polymer material with a Young's modulus (also known as tensile modulus, elastic modulus, or traction modulus) in the following ranges: about 5 MPa to about 8 MPa, or about 5.1 MPa to about 7.9 MPa, or about 5.2 MPa to about 7.8 MPa, or about 5.3 MPa to about 7.7 MPa, or about 5.4 MPa to about 7.6 MPa, or about 5.5 MPa to about 7.5 MPa, or about 5.6 MPa to about 7.4 MPa, or about 5.7 MPa to about 7.3 MPa, or about 5.8 MPa to about 7.2 MPa, or about 5.9 MPa to about 7.1 MPa, or about 6 MPa to about 7 MPa, or about 6.1 MPa to about 6.9 MPa, or about 6.2 MPa to about 6.8 MPa, or about 6.3 MPa to about 6.7 MPa, or from about 6.4 MPa to about 6.6 MPa. MPa; or even made of any suitable polymeric material with a Young's modulus of about 6.5 MPa. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed, numerical ranges.

[0055] In one embodiment, the desired Shore A hardness of the stop 38 of any syringe that can be used in conjunction with the present invention is about 45 to about 85, or about 50 to about 80, or about 55 to about 75, or about 60 to about 70, or even about 65. In another embodiment, the stop 38 is ideally made of any suitable polymeric material with a Shore A hardness of about 50 to about 80, or about 52 to about 78, or about 54 to about 76, or about 56 to about 74, or about 58 to about 72, or about 60 to about 70, or about 62 to about 68, or about 64 to about 66, or even about 65. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed numerical ranges.

[0056] Suitable stop polymeric materials include, but are not limited to, one or more polyolefins (e.g., PE, PP and their copolymers), one or more polyamides (e.g., nylon), one or more polyesters (e.g., PET), one or more polystyrene, one or more polyurethanes, one or more polycarbonates, one or more acrylonitrile-butadiene-styrene, one or more fluoropolymers, one or more polyacrylates, one or more elastic rubbers, or blends of any two or more of them that satisfy at least one of Young's modulus and / or Shore A as defined above. In another embodiment, suitable stop material includes, but is not limited to, polymeric materials selected from one or more polyisoprene (including, but not limited to, natural rubber), one or more polyisobutylene, one or more synthetic polyisoprene, one or more polybutadiene (generally referred to as butadiene rubber), one or more chloroprene rubbers (e.g., polychloroprene, chloroprene rubber, etc.), one or more butyl rubbers (i.e., copolymers of isobutylene and isoprene), one or more halogenated butyl rubbers (e.g., chlorinated butyl rubber or brominated butyl rubber), one or more styrene-butadiene rubbers (i.e., copolymers of styrene and butadiene), one or more nitrile rubbers (i.e., copolymers of butadiene and acrylonitrile), one or more hydrogenated nitrile rubbers, natural rubber, one or more ethylene propylene rubbers, one or more ethylene propylene diene rubbers, or blends of any two or more thereof. In another embodiment, suitable stop polymeric materials include, but are not limited to, one or more butadiene rubbers, one or more halogenated butyl rubbers (e.g., chlorinated butyl rubber or brominated butyl rubber), or blends of any two or more thereof.

[0057] In another embodiment, the stop 38 is ideally made of any suitable polymeric material with a Young's modulus and / or Shore A hardness within one of the aforementioned ranges and having a high Mooney viscosity. High Mooney rubber is defined as rubber with a Mooney viscosity greater than about 40, or greater than about 45, or greater than about 50, or greater than about 55, or greater than about 60, or greater than about 65, or even greater than about 70. Here, and elsewhere in the specification and claims, individual numerical values ​​may be combined to form additional, or even new / undisclosed numerical ranges.

[0058] Suitable high Mooney viscosity rubbers include, but are not limited to, one or more polybutadiene rubbers, one or more polyisobutylene rubbers, one or more polyisoprene rubbers, natural rubber, one or more ethylene propylene rubbers, one or more ethylene propylene rubbers, one or more styrene-butadiene rubbers, or blends of any two or more thereof.

[0059] In one embodiment, the stop 38 is made of a polymeric material, which has a significantly lower coefficient of friction and contact area / pressure compared to conventional rubber stops. Therefore, in this embodiment, the stop 38 can be used with the syringe 10 without silicone oil or other lubricants. Furthermore, the syringe barrel 12 can be made of the same, similar, or even completely different material as the material used to form the stop 38.

[0060] In one embodiment, a suitable seal is achieved by contact pressure through any one or more stops, depending on the syringe that can be used in conjunction with the invention, because the polymeric material is used to form the stop (or any disclosed alternative stop design incorporated herein by reference), wherein the stop is formed of any one or more polymeric materials having one or more of the properties disclosed herein. That is, suitable sealing performance of the stop for any syringe that can be used in conjunction with the invention is achieved by one or more of the following: the geometry of the stop, the Young's modulus of the polymeric material used to form such a stop, the indentation modulus of the laminate sealing surface, and / or the roughness of the stop surface and / or the inner surface of the cylinder (or other container) to which the stop is designed to seal.

[0061] In one embodiment, the surface roughness of the glass, polymer, metal, or other type of material forming the surface sealed by the stop of any syringe that can be used in conjunction with the present invention (e.g., a vial, syringe, or other type of container) is independently within the following ranges: about 0.0001 micrometers to about 6 micrometers, or about 0.0002 micrometers to about 5.9 micrometers, or about 0.0003 micrometers to about 5.8 micrometers, or about 0.0004 micrometers to about 5.7 micrometers, or about 0.0005 micrometers to about 5.6 micrometers, or about 0.0006 micrometers to about 5.5 micrometers, or about 0.0007 micrometers to about 5.4 micrometers, or about 0.0008 micrometers to about 5.3 micrometers, or about 0.0009 micrometers to about 5.2 micrometers, or about 0.001 micrometers to about 5.1 micrometers, about 0.0011 micrometers to about 5 micrometers, or about 0.0012 micrometers to about 4.9 micrometers, or about 0.0013 micrometers to about 4.8 micrometers, or about 0.0014 micrometers to about 4.7 micrometers, or about 0.0015 micrometers to about 4.6 micrometers, or about 0.0016 micrometers to about 4.5 micrometers, or about 0.0017 micrometers to about 4.4 micrometers, or about 0.0018 micrometers to about 4.3 micrometers, or about 0.0019 micrometers to about 4.2 micrometers, about 0.002 micrometers to about 4.1 micrometers, or about 0.0021 micrometers to about 4 micrometers, or about 0.0022 micrometers to about 3.9 micrometers, or about 0.0023 micrometers to about 3.8 micrometers, or about 0.0024 micrometers to about 4.5 micrometers, or about 0.0024 micrometers to about 4 ... Micrometers to about 3.7 micrometers, or about 0.0025 micrometers to about 3.6 micrometers, or about 0.0026 micrometers to about 3.5 micrometers, or about 0.0027 micrometers to about 3.4 micrometers, or about 0.0028 micrometers to about 3.3 micrometers, or about 0.0029 micrometers to about 3.2 micrometers, or about 0.003 micrometers to about 3.1 micrometers, or about 0.0031 micrometers to about 3 micrometers, or about 0.0032 micrometers to about 2.9 micrometers, or about 0.0033 micrometers to about 2.8 micrometers, or about 0.0034 micrometers to about 2.7 micrometers, or about 0.0035 micrometers to about 2.6 micrometers, or about 0.0036 micrometers to about 2.5 micrometers, or about 0.0037 micrometers to about 2.4 micrometers, or about 0.0038 micrometers... From about 2.3 micrometers, or about 0.0039 micrometers to about 2.2 micrometers, or about 0.004 micrometers to about 2.1 micrometers, or about 0.0041 micrometers to about 2 micrometers, or about 0.0042 micrometers to about 1.9 micrometers, or about 0.0043 micrometers to about 1.8 micrometers, or about 0.0044 micrometers to about 1.7 micrometers, or about 0.0045 micrometers to about 1.6 micrometers, or about 0.0046 micrometers to about 1.5 micrometers, or about 0.0047 micrometers to about 1.4 micrometers, or about 0.0048 micrometers to about 1.3 micrometers, or about 0.0049 micrometers to about 1.2 micrometers, or about 0.005 micrometers to about 1.1 micrometers, or about 0.0051 micrometers to about 1 micrometer, or about 0.0052 micrometers to about 0.9 micrometers, or about 0.0053 micrometers to about 0.8 micrometers, or about 0.0054 micrometers to about 0.7 micrometers, or about 0.0055 micrometers to about 0.6 micrometers, or about 0.0056 micrometers to about 0.5 micrometers, or about 0.0057 micrometers to about 0.4 micrometers, or about 0.0058 micrometers to about 0.3 micrometers, or about 0.0059 micrometers to about 0.2 micrometers, or about 0.006 micrometers to about 0.1 micrometers, or about 0.0065 micrometers to about 0.095 micrometers, or about 0.007 micrometers to about 0.09 micrometers, or about 0.0075 micrometers to about 0.085 micrometers. The surface roughness may be approximately 0.008 micrometers to approximately 0.08 micrometers, or approximately 0.0085 micrometers to approximately 0.075 micrometers, or approximately 0.009 micrometers to approximately 0.07 micrometers, or approximately 0.0095 micrometers to approximately 0.065 micrometers, or approximately 0.01 micrometers to approximately 0.06 micrometers, or approximately 0.015 micrometers to approximately 0.055 micrometers, or approximately 0.02 micrometers to approximately 0.05 micrometers, or approximately 0.025 micrometers to approximately 0.045 micrometers, or approximately 0.03 micrometers to approximately 0.04 micrometers, or even 0.035 micrometers, and this surface roughness is measured by an optical interferometer at 50x magnification. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed numerical ranges.

[0062] In one embodiment, the surface roughness of the polymer material used to form the stop of any syringe that can be used in conjunction with the present invention is independently within the following ranges: about 0.0001 micrometers to about 6 micrometers, or about 0.0002 micrometers to about 5.9 micrometers, or about 0.0003 micrometers to about 5.8 micrometers, or about 0.0004 micrometers to about 5.7 micrometers, or about 0.0005 micrometers to about 5.6 micrometers, or about 0.0006 micrometers to about 5.5 micrometers, or about 0.0007 micrometers to about 5.4 micrometers, or about 0.0008 micrometers to about 5.3 micrometers, or about 0.0009 micrometers to about 5.2 micrometers, or about 0.001 micrometers to about 5.1 micrometers, or about 0.0011 micrometers to about 5 micrometers, or about 0.0012 micrometers to about 4.9 micrometers, or about 0.0013 micrometers to about 4.8 micrometers, or about 0.0014 micrometers to about 4.7 micrometers, or about 0.0015 micrometers to about 4.6 micrometers, or about 0.0016 micrometers to about 4.5 micrometers, or about 0.0017 micrometers to about 4.4 micrometers, or about 0.0018 micrometers to about 4.3 micrometers, or about 0.0019 micrometers to about 4.2 micrometers, or about 0.002 micrometers to about 4.1 micrometers, or about 0.0021 micrometers to about 4 micrometers, or about 0.0022 micrometers to about 3.9 micrometers, or about 0.0023 micrometers to about 3.8 micrometers, or about 0.0024 micrometers to about 3.7 micrometers, or about 0.0025 micrometers to about 3.6 micrometers, or about 0.0026 micrometers to about 3.5 micrometers, or about 0.0027 micrometers to about 3.4 micrometers, or about 0.0028 micrometers to about 3.3 micrometers, or about 0.0029 micrometers to about 3.2 micrometers, or about 0.003 micrometers to about 3.1 micrometers, or about 0.0031 micrometers to about 3 micrometers, or about 0.0032 micrometers to about 2.9 micrometers, or about 0.0033 micrometers to about 2.8 micrometers, or about 0.0034 micrometers to about 2.7 micrometers, or about 0.0035 micrometers to about 2.6 micrometers, or about 0.0036 micrometers to about 2.5 micrometers, or about 0.0037 micrometers to about 2.4 micrometers, or about 0.0038 micrometers to about 2.3 micrometers, or about 0.0039 micrometers to about 2.2 micrometers, or About 0.004 micrometers to about 2.1 micrometers, or about 0.0041 micrometers to about 2 micrometers, or about 0.0042 micrometers to about 1.9 micrometers, or about 0.0043 micrometers to about 1.8 micrometers, or about 0.0044 micrometers to about 1.7 micrometers, or about 0.0045 micrometers to about 1.6 micrometers, or about 0.0046 micrometers to about 1.5 micrometers, or about 0.0047 micrometers to about 1.4 micrometers, or about 0.0048 micrometers to about 1.3 micrometers, or about 0.0049 micrometers to about 1.2 micrometers, or about 0.005 micrometers to about 1.1 micrometers, or about 0.0051 micrometers to about 1 micrometer, or about 0.0052 micrometers to about 0.9 micrometers, or about 0.0053 micrometers to about 0.8 micrometers, or about 0.0.0054 micrometers to about 0.7 micrometers, or about 0.0055 micrometers to about 0.6 micrometers, or about 0.0056 micrometers to about 0.5 micrometers, or about 0.0057 micrometers to about 0.4 micrometers, or about 0.0058 micrometers to about 0.3 micrometers, or about 0.0059 micrometers to about 0.2 micrometers, or about 0.006 micrometers to about 0.1 micrometers, or about 0.0065 micrometers to about 0.095 micrometers, or about 0.007 micrometers to about 0.09 micrometers, or about 0.0075 micrometers to about 0.085 micrometers, or about 0.008 micrometers to about 0. The surface roughness is 0.08 micrometers, or about 0.0085 micrometers to about 0.075 micrometers, or about 0.009 micrometers to about 0.07 micrometers, or about 0.0095 micrometers to about 0.065 micrometers, or 0.01 micrometers to about 0.06 micrometers, or about 0.015 micrometers to about 0.055 micrometers, or about 0.02 micrometers to about 0.05 micrometers, or about 0.025 micrometers to about 0.045 micrometers, or about 0.03 micrometers to about 0.04 micrometers; or even 0.035 micrometers, measured by an optical interferometer at 50x magnification. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed ranges of values.

[0063] In another embodiment, if the surface to be sealed is partially or fully laminated, the surface roughness of the laminate, or, in the case of using two or more layers to provide a monolithic laminated coating, the surface roughness of the top laminate, independently falls within the following ranges: about 0.0001 micrometers to about 12 micrometers, or about 0.0002 micrometers to about 11.9 micrometers, or about 0.0003 micrometers to about 11.8 micrometers, or about 0.0004 micrometers to about 11.7 micrometers, or about 0.0005 micrometers to about 11.6 micrometers, or about 0.0006 micrometers to about 11.5 micrometers, or about 0.0007 micrometers to about 11.4 micrometers, or about 0.0008 micrometers to about 11.3 micrometers, or about 0.0009 micrometers to about 11. 0.2 micrometers, or about 0.001 micrometers to about 11.1 micrometers, or about 0.0011 micrometers to about 11 micrometers, or about 0.0012 micrometers to about 10.9 micrometers, or about 0.0013 micrometers to about 10.8 micrometers, or about 0.0014 micrometers to about 10.7 micrometers, or about 0.0015 micrometers to about 10.6 micrometers, or about 0.0016 micrometers to about 10.5 micrometers, or about 0.0017 micrometers to about 10.4 micrometers, or about 0.0018 micrometers to about 10.3 micrometers, or about 0.0019 micrometers to about 10.2 micrometers, or about 0.002 micrometers to about 10.1 micrometers, or about 0.0021 micrometers to about 10 micrometers, or about 0.0022 micrometers to about 9.9 micrometers, or about 0. 0.0023 micrometers to about 9.8 micrometers, or about 0.0024 micrometers to about 9.7 micrometers, or about 0.0025 micrometers to about 9.6 micrometers, or about 0.0026 micrometers to about 9.5 micrometers, or about 0.0027 micrometers to about 9.4 micrometers, or about 0.0028 micrometers to about 9.3 micrometers, or about 0.0029 micrometers to about 9.2 micrometers, or about 0.003 micrometers to about 9.1 micrometers, or about 0.0031 micrometers to about 9 micrometers, or about 0.0032 micrometers to about 8.9 micrometers, or about 0.0033 micrometers to about 8.8 micrometers, or about 0.0034 micrometers to about 8.7 micrometers, or about 0.0035 micrometers to about 8.6 micrometers, or about 0.0036 micrometers to about 8.5 micrometers, or about 0. 0.0037 micrometers to about 8.4 micrometers, or about 0.0038 micrometers to about 8.3 micrometers, or about 0.0039 micrometers to about 8.2 micrometers, or about 0.004 micrometers to about 8.1 micrometers, or about 0.0041 micrometers to about 8 micrometers, or about 0.0042 micrometers to about 7.9 micrometers, or about 0.0043 micrometers to about 7.8 micrometers, or about 0.0044 micrometers to about 7.7 micrometers, or about 0.0045 micrometers to about 7.6 micrometers, or about 0.0046 micrometers to about 7.5 micrometers, or about 0.0047 micrometers to about 7.4 micrometers, or about 0.0048 micrometers to about 7.3 micrometers, or about 0.0049 micrometers to about 7.2 micrometers, or about 0.005 micrometers to about 7.1 micrometers, or about 0.0.0051 micrometers to about 7 micrometers, or about 0.0052 micrometers to about 6.9 micrometers, or about 0.0053 micrometers to about 6.8 micrometers, or about 0.0054 micrometers to about 6.7 micrometers, or about 0.0055 micrometers to about 6.6 micrometers, or about 0.0056 micrometers to about 6.5 micrometers, or about 0.0057 micrometers to about 6.4 micrometers, or about 0.0058 micrometers to about 6.3 micrometers, or about 0.0059 micrometers to about 6.2 micrometers, or about 0.006 micrometers to about 6.1 micrometers, or about 0.0065 micrometers to about 6 micrometers, or about 0.007 micrometers to about 5.9 micrometers, or about 0.0075 micrometers to about 5.8 micrometers, or about 0.008 Micrometers to about 5.7 micrometers, or about 0.0085 micrometers to about 5.6 micrometers, or about 0.009 micrometers to about 5.5 micrometers, or about 0.0095 micrometers to about 5.4 micrometers, or about 0.01 micrometers to about 5.3 micrometers, or about 0.015 micrometers to about 5.2 micrometers, or about 0.02 micrometers to about 5.1 micrometers, or about 0.025 micrometers to about 5 micrometers, or about 0.03 micrometers to about 4.9 micrometers, or about 0.035 micrometers to about 4.8 micrometers, or about 0.04 micrometers to about 4.7 micrometers, or about 0.045 micrometers to about 4.6 micrometers, or about 0.05 micrometers to about 4.5 micrometers, or about 0.055 micrometers to about 4.4 micrometers, or about 0.06 micrometers to about 5.7 micrometers, or about 0.0085 micrometers to about 5.6 micrometers, or about 0.009 micrometers to about 5.5 micrometers, or about 0.0095 micrometers to about 5.4 micrometers, or about 0.01 micrometers to about 5.3 micrometers, or about 0.015 micrometers to about 5.2 micrometers, or about 0.02 micrometers to about 5.1 micrometers, or about 0.025 micrometers to about 5 micrometers, or about 0.03 micrometers to about 4.9 micrometers, or about 0.035 micrometers to about 4.8 micrometers, or about 0.04 micrometers to about 4.7 micrometers, or about 0 Micrometers to about 4.3 micrometers, or about 0.065 micrometers to about 4.2 micrometers, or about 0.07 micrometers to about 4.1 micrometers, or about 0.075 micrometers to about 4 micrometers, or about 0.08 micrometers to about 3.9 micrometers, or about 0.085 micrometers to about 3.8 micrometers, or about 0.09 micrometers to about 3.7 micrometers, or about 0.095 micrometers to about 3.6 micrometers, or about 0.1 micrometers to about 3.5 micrometers, or about 0.15 micrometers to about 3.4 micrometers, or about 0.2 micrometers to about 3.3 micrometers, or about 0.25 micrometers to about 3.2 micrometers, or about 0.3 micrometers to about 3.1 micrometers, or about 0.35 micrometers to about 3 micrometers, or about 0.4 micrometers to about 2.9 micrometers, or about 0.45 micrometers to about 2.8 micrometers, or about 0.5 micrometers to about 2.7 micrometers, or about 0.55 micrometers to about 2.6 micrometers, or about 0.6 micrometers to about 2.5 micrometers, or about 0.65 micrometers to about 2.4 micrometers, or about 0.7 micrometers to about 2.3 micrometers, or about 0.75 micrometers to about 2.2 micrometers, or about 0.8 micrometers to about 2.1 micrometers, or about 0.85 micrometers to about 2 micrometers, or about 0.9 micrometers to about 1.9 micrometers, or about 0.95 micrometers to about 1.8 micrometers, or about 1 micrometer to about 1.7 micrometers, or about 1.1 micrometers to about 1.6 micrometers, or about 1.2 micrometers to about 1.5 micrometers, or about 1.3 micrometers to about 1.4 micrometers; or even about 1.The surface roughness of 35 micrometers was measured using an optical interferometer at 50x magnification. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed, numerical ranges.

[0064] In another embodiment, if the stop of any syringe that can be used in conjunction with the present invention is partially or entirely laminated, the surface roughness of the laminated film, or the surface roughness of the topmost laminated film when two or more layers are used to provide an integral laminated coating, is independently within the following ranges: about 0.0001 micrometers to about 6 micrometers, or about 0.0002 micrometers to about 5.9 micrometers, or about 0.0003 micrometers to about 5.8 micrometers, or about 0.0004 micrometers to about 5.7 micrometers, or about 0.0005 micrometers to about 5.6 micrometers, or about 0.0006 micrometers to about 5.5 micrometers, or about 0.0007 micrometers to about 5.4 micrometers, or about 0.0008 micrometers to about 5. 0.3 micrometers, or about 0.0009 micrometers to about 5.2 micrometers, or about 0.001 micrometers to about 5.1 micrometers, or about 0.0011 micrometers to about 5 micrometers, or about 0.0012 micrometers to about 4.9 micrometers, or about 0.0013 micrometers to about 4.8 micrometers, or about 0.0014 micrometers to about 4.7 micrometers, or about 0.0015 micrometers to about 4.6 micrometers, or about 0.0016 micrometers to about 4.5 micrometers, or about 0.0017 micrometers to about 4.4 micrometers, or about 0.0018 micrometers to about 4.3 micrometers, or about 0.0019 micrometers to about 4.2 micrometers, or about 0.002 micrometers to about 4.1 micrometers, or about 0.0021 micrometers to about 4 micrometers. or about 0.0022 micrometers to about 3.9 micrometers, or about 0.0023 micrometers to about 3.8 micrometers, or about 0.0024 micrometers to about 3.7 micrometers, or about 0.0025 micrometers to about 3.6 micrometers, or about 0.0026 micrometers to about 3.5 micrometers, or about 0.0027 micrometers to about 3.4 micrometers, or about 0.0028 micrometers to about 3.3 micrometers, or about 0.0029 micrometers to about 3.2 micrometers, or about 0.003 micrometers to about 3.1 micrometers, or about 0.0031 micrometers to about 3 micrometers, or about 0.0032 micrometers to about 2.9 micrometers, or about 0.0033 micrometers to about 2.8 micrometers, or about 0.0034 micrometers to about 2.7 micrometers. or about 0.0035 micrometers to about 2.6 micrometers, or about 0.0036 micrometers to about 2.5 micrometers, or about 0.0037 micrometers to about 2.4 micrometers, or about 0.0038 micrometers to about 2.3 micrometers, or about 0.0039 micrometers to about 2.2 micrometers, or about 0.004 micrometers to about 2.1 micrometers, or about 0.0041 micrometers to about 2 micrometers, or about 0.0042 micrometers to about 1.9 micrometers, or about 0.0043 micrometers to about 1.8 micrometers, or about 0.0044 micrometers to about 1.7 micrometers, or about 0.0045 micrometers to about 1.6 micrometers, or about 0.0046 micrometers to about 1.5 micrometers, or about 0.0047 micrometers to about 1.4 micrometers, Or about 0.0048 micrometers to about 1.3 micrometers, or about 0.0049 micrometers to about 1.2 micrometers, or about 0.005 micrometers to about 1.1 micrometers, or about 0.0051 micrometers to about 1 micrometer, or about 0.0.0052 micrometers to about 0.9 micrometers, or about 0.0053 micrometers to about 0.8 micrometers, or about 0.0054 micrometers to about 0.7 micrometers, or about 0.0055 micrometers to about 0.6 micrometers, or about 0.0056 micrometers to about 0.5 micrometers, or about 0.0057 micrometers to about 0.4 micrometers, or about 0.0058 micrometers to about 0.3 micrometers, or about 0.0059 micrometers to about 0.2 micrometers, or about 0.006 micrometers to about 0.1 micrometers, or about 0.0065 micrometers to about 0.095 micrometers, or about 0.007 micrometers to about 0.09 micrometers, or about 0.0075 micrometers to about 0. The surface roughness is 0.085 micrometers, or about 0.008 micrometers to about 0.08 micrometers, or about 0.0085 micrometers to about 0.075 micrometers, or about 0.009 micrometers to about 0.07 micrometers, or about 0.0095 micrometers to about 0.065 micrometers, or about 0.01 micrometers to about 0.06 micrometers, or about 0.015 micrometers to about 0.055 micrometers, or about 0.02 micrometers to about 0.05 micrometers, or about 0.025 micrometers to about 0.045 micrometers, or about 0.03 micrometers to about 0.04 micrometers; or even 0.035 micrometers, measured by an optical interferometer at 50x magnification. Herein, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed ranges of values.

[0065] In embodiments where the syringe barrel is made of glass, the compression ratio of the stop to the inner diameter of the glass barrel is about 1% to about 10%, or about 1.25% to about 9.75%, or about 1.5% to about 9.5%, or about 1.75% to about 9.25%, or about 2% to about 9%, or about 2.25% to about 8.75%, or about 2.5% to about 8.5%, or about 2.75% to about 8.25%, or about 3% to about 8%, or about 3.25% to about 7.75%, or about 3.5% to about 7.5%. The compression ratio is approximately 5.5%, or about 3.75% to about 7.25%, or about 4% to about 7%, or about 4.25% to about 6.75%, or about 4.5% to about 6.5%, or about 4.75% to about 6.25%, or about 5% to about 6%, or about 5.25% to about 5.75%, or even about 5.5%, determined based on the nominal size, which is the ratio of the maximum outer diameter of the stop in the free state to the minimum inner diameter of the sealing cylinder (in some cases, taking into account the possible slope on the inner diameter of the cylinder). Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed ranges of values.

[0066] In one embodiment, according to any syringe that can be used in conjunction with the invention, the contact pressure generated by the stop formed of the polymeric material at the sealing surface (glass, polymer, metal, or other type of material forming the surface to be sealed), measured over a width of about 0.01 mm, is greater than about 90% of the indentation modulus or yield strength of the corresponding polymeric material film used to form such a stop. It is well known that the indentation modulus describes the elastic surface behavior of a material (in this case, a polymeric material) during indentation. In another embodiment, the contact pressure generated at the sealing surface, measured over a width of about 0.01 mm, is greater than about 91%, about 92%, about 93%, about 94%, about 95%, or even about 96% of the indentation modulus or yield strength of the corresponding polymeric material film used to form such a stop. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed ranges of values. Alternatively, any of the above contact pressure values ​​can be determined by comparing them to the contact pressure of the desired polymeric material at 50% elongation modulus.

[0067] In one embodiment, the rubber matrix modulus of the polymeric material used to form the stop of any syringe that can be used in conjunction with the present invention is in the range of: about 4 MPa to about 8 MPa, or about 4.25 MPa to about 7.75 MPa, or about 4.5 MPa to about 7.5 MPa, or about 4.75 MPa to about 7.25 MPa, or about 5 MPa to about 7 MPa, or about 5.25 MPa to about 6.75 MPa, or about 5.5 MPa to about 6.5 MPa, or about 5.75 MPa to about 6.25 MPa; or even about 6 MPa, which is measured at the stress-strain limit of a molded part formed of the desired polymeric material without a laminate thereon. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed numerical ranges.

[0068] In one embodiment, any syringe that can be used in conjunction with the present invention achieves a seal (permeability threshold) by utilizing various correlations between stop geometry, roughness, surface indentation modulus, and / or matrix material modulus, independent of the surface energy of the sealing surface. Similarly, in one embodiment, the stop of any syringe that can be used in conjunction with the present invention is partially laminated, thus each stop having an elastomer, one or more fluoropolymer layers, and one or more ribs (or even two or more ribs) laminated with one or more fluoropolymer layers. In another embodiment, the stop of any syringe that can be used in conjunction with the present invention is fully laminated, with all stops laminated with one or more fluoropolymer layers. In one embodiment, the one or more fluoropolymer layers described herein may comprise a single layer of dense expanded polytetrafluoroethylene (ePTFE), or the one or more fluoropolymer layers may comprise a composite fluoropolymer membrane having a barrier layer and a porous layer, the barrier layer comprising dense ePTFE, polytetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), polyethylene, polypropylene, polyvinylidene fluoride, polyvinyl fluoride, perfluoropropyl vinyl ether, perfluoroalkoxy polymers, copolymers and combinations thereof. In another embodiment, any high-temperature material (e.g., a polymeric material) can be used to form one or more laminates.

[0069] In another embodiment, the stop of the present invention is partially laminated, each stop having a body formed of any polymeric material disclosed herein. In another embodiment, the stop of the present invention is partially laminated, each stop having a body formed of any polymeric material having at least the Young's modulus and Shore A hardness disclosed herein, and which can be processed as described herein. In one case, the body of any stop disclosed herein may be partially or even completely laminated with one or more fluoropolymer layers, and has one or more ribs (or even two or more ribs) laminated with one or more fluoropolymer layers. In another embodiment, the stop of the present invention is fully laminated, with all stop body and ribs laminated with one or more fluoropolymer layers. In one embodiment, one or more fluoropolymer layers described herein may comprise a single layer of dense expanded polytetrafluoroethylene (ePTFE), or one or more fluoropolymer layers may comprise a composite fluoropolymer membrane having a barrier layer and a porous layer, wherein the barrier layer comprises dense ePTFE, polytetrafluoroethylene (PTFE), fluorinated ethylene propylene (FEP), polyethylene (e.g., UHMWPE), polypropylene (e.g., syndiotactic-PP), polyvinylidene fluoride, polyvinyl fluoride, perfluoropropyl vinyl ether, perfluoroalkoxy polymers, polysulfone, and copolymers and combinations thereof. In yet another embodiment, any high-temperature material (e.g., polymeric material) may be used to form one or more laminated layers, regardless of whether the stop according to this embodiment is partially laminated or even fully laminated. In yet another embodiment, the stop of the present invention is laminated from one or more non-fluoropolymer materials. Suitable non-fluoropolymer materials for such laminates include, but are not limited to, UHMWPE, syndiotactic-polypropylene blends, and / or polysulfone.

[0070] like Figure 3 As best shown, for the syringe 10 described above, a coloring oil 80 can be applied to at least a portion of the syringe (e.g., the syringe barrel 12). The following is a discussion of one type of exemplary coloring oil 80. However, it should be understood that the following coloring oil compositions are merely representative, and the invention is not limited to the various compositions disclosed herein. Rather, any coloring oil composition within the spirit of the disclosure contained herein can be used in conjunction with the invention.

[0071] In one embodiment, the coloring oil of the present invention comprises a combination of at least one oil and at least one coloring compound, the oil being selected from one or more silicone oils, one or more hydrocarbon oils, or any two or more combinations thereof, the viscosity of the at least one oil being in the range of about 500 centipoise to about 1500 centipoise, and the coloring compound being selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more combinations thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0072] In view of the above, in one embodiment, the oil component of the present invention is one or more silicone oils selected from one or more polydimethylsiloxanes (PDMS) (also known as dimethyl silicone oil), mixtures of polydimethylsiloxanes (PDMS) and simethicone, polymethylhydrosiloxane oil, amino silicone oil, phenylmethyl silicone oil, vinyl silicone oil, hydrosilicone oil, or combinations of two or more thereof, provided that the viscosity or total viscosity of the one or more silicone oils is in the range of about 500 centipoise to about 1500 centipoise. In another embodiment, the oil component of the present invention may be selected from any one or more suitable food-grade oils and / or any one or more medical-grade oils, provided that the viscosity or total viscosity of such oil or mixture of oils is in the range of about 500 centipoise to about 1500 centipoise. In yet another embodiment, the oil component of the present invention is a combination of one or more silicone oils and one or more hydrocarbon oils, provided that the viscosity or total viscosity of the combined oil component is in the range of about 500 centipoise to about 1500 centipoise. In yet another embodiment, the oil component of the present invention may be selected from any one or more of the aforementioned oils in combination with any one or more suitable viscosity modifiers, provided that the viscosity or total viscosity of such oil-viscosity modifier mixture is in the range of about 500 centipoise to about 1500 centipoise. It should be noted that in this embodiment, any one or more viscosity modifiers are selected so as not to interfere with the UV properties of at least one coloring compound used in conjunction with the present invention. In one embodiment, suitable viscosity modifiers include, but are not limited to, any viscosity modifier suitable for food-grade and / or medical-grade applications, provided that such viscosity modifier does not interfere with the UV properties of at least one coloring compound used in conjunction with the present invention. In another embodiment, a suitable medical-grade viscosity modifier may be selected from any suitable polymer-based medical-grade viscosity modifier, provided that such viscosity modifier does not interfere with the UV properties of at least one coloring compound used in conjunction with the present invention.

[0073] In another embodiment, the viscosity of the oil component of the present invention is in the following ranges: about 510 centipoise to about 1490 centipoise, or about 520 centipoise to about 1480 centipoise, or about 530 centipoise to about 1470 centipoise, or about 540 centipoise to about 1460 centipoise, or about 550 centipoise to about 1450 centipoise, or about 560 centipoise to about 1440 centipoise, or about 570 centipoise to about 1430 centipoise, or about 580 centipoise to about 1420 centipoise, or about 590 centipoise to about 1410 centipoise, or about 600 centipoise to about 1400 centipoise, or about 610 centipoise to about 1390 centipoise, or about 620 centipoise to about 1490 centipoise. From approximately 1380 centipoise to approximately 1370 centipoise, or approximately 640 centipoise to approximately 1360 centipoise, or approximately 650 centipoise to approximately 1350 centipoise, or approximately 660 centipoise to approximately 1340 centipoise, or approximately 670 centipoise to approximately 1330 centipoise, or approximately 680 centipoise to approximately 1320 centipoise, or approximately 690 centipoise to approximately 1310 centipoise, or approximately 700 centipoise to approximately 1300 centipoise, or approximately 710 centipoise to approximately 1290 centipoise, or approximately 720 centipoise to approximately 1280 centipoise, or approximately 730 centipoise to approximately 1270 centipoise, or approximately 740 centipoise to approximately 1260 centipoise, or approximately 750 centipoise to approximately 1250 centipoise, or approximately 760 centipoise to approximately 1240 centipoise, or approximately 770 centipoise to approximately 1230 centipoise, or approximately 780 centipoise to approximately 1220 centipoise, or approximately 790 centipoise to approximately 1210 centipoise, or approximately 800 centipoise to approximately 1200 centipoise, or approximately 810 centipoise to approximately 1190 centipoise, or approximately 820 centipoise to approximately 1180 centipoise, or approximately 830 centipoise to approximately 1170 centipoise, or approximately 840 centipoise to approximately 1160 centipoise, or approximately 850 centipoise to approximately 1150 centipoise, or approximately 860 centipoise to approximately 1140 centipoise, or approximately 870 centipoise to approximately 1130 centipoise. The range may be approximately 880 centipoise to approximately 1120 centipoise, or approximately 890 centipoise to approximately 1110 centipoise, or approximately 900 centipoise to approximately 1100 centipoise, or approximately 910 centipoise to approximately 1090 centipoise, or approximately 920 centipoise to approximately 1080 centipoise, or approximately 930 centipoise to approximately 1070 centipoise, or approximately 940 centipoise to approximately 1060 centipoise, or approximately 950 centipoise to approximately 1050 centipoise, or approximately 960 centipoise to approximately 1040 centipoise, or approximately 970 centipoise to approximately 1030 centipoise, or approximately 980 centipoise to approximately 1020 centipoise, or approximately 990 centipoise to approximately 1010 centipoise; or even approximately 1000 centipoise. Herein, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed ranges of values.

[0074] In view of the above, in one embodiment, at least one coloring compound is selected from one or more fluorescent acrylic compositions (e.g., Daler Rowney System 3 acrylic and / or Golden High flow acrylic fluorescent yellow-green), one or more ultraviolet dyes, or any combination of two or more thereof, provided that the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

[0075] In another embodiment, at least one coloring compound of the present invention fluoresces at wavelengths of about 110 nm to about 390 nm, or about 120 nm to about 380 nm, or about 130 nm to about 370 nm, or about 140 nm to about 360 nm, or about 150 nm to about 350 nm, or about 160 nm to about 340 nm, or about 170 nm to about 330 nm, or about 180 nm to about 320 nm, or about 190 nm to about 310 nm, or about 200 nm to about 300 nm, or about 210 nm to about 290 nm, or about 220 nm to about 280 nm, or about 230 nm to about 270 nm, or about 240 nm to about 260 nm, or even about 250 nm. Here, and elsewhere in the specification and claims, individual values ​​may be combined to form additional, or even new / undisclosed numerical ranges.

[0076] In view of the above, in one embodiment, the amount of at least one coloring compound added to at least one oil component of the present invention is in the following range: about 0.1 vol% to about 3 vol% of at least one coloring compound per 100 vol% of coloring oil. In another embodiment, the amount of at least one coloring compound added to at least one oil component of the present invention is in the following range: about 0.15 vol% to about 2.95 vol% per 100 vol% of coloring oil, or about 0.2 vol% to about 2.9 vol%, or about 0.25 vol% to about 2.85 vol%, or about 0.3 vol% to about 2.8 vol%, or about 0.35 vol% to about 2.75 vol%, or about 0.4 vol% to about 2.7 vol%, or about 0.45 vol% to about 2.7 vol%. About 2.65% by volume, or about 0.5% by volume to about 2.6% by volume, or about 0.55% by volume to about 2.55% by volume, or about 0.6% by volume to about 2.5% by volume, or about 0.65% by volume to about 2.45% by volume, or about 0.7% by volume to about 2.4% by volume, or about 0.75% by volume to about 2.35% by volume, or about 0.8% by volume to about 2.3% by volume, or about 0.85% by volume to about 2.25% by volume, or about 0.9% by volume to about 2.2% by volume. Or about 0.95 vol% to about 2.15 vol%, or about 1 vol% to about 2.1 vol%, or about 1.05 vol% to about 2.05 vol%, or about 1.1 vol% to about 2 vol%, or about 1.15 vol% to about 1.95 vol%, or about 1.2 vol% to about 1.9 vol%, or about 1.25 vol% to about 1.85 vol%, or about 1.3 vol% to about 1.8 vol%, or about 1.35 vol% to about 1.75 vol%, or about 1.4 vol% to about 1.7 vol%, or about 1.45 vol% to about 1.65 vol%, or about 1.5 vol% to about 1.6 vol% of at least one coloring compound; or even about 1.55 vol% of at least one coloring compound per 100 vol% of coloring oil.

[0077] In view of the above, in one embodiment, the present invention relates to a coloring oil comprising a combination of at least one oil and at least one coloring compound, wherein the oil is selected from one or more silicone oils, one or more hydrocarbon oils, or any two or more combinations thereof, the viscosity of the at least one oil being in the range of about 500 centipoise to about 1500 centipoise, and the coloring compound being selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more combinations thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm. In another embodiment, in the coloring oil of the present invention, at least one oil is selected from at least one silicone oil. In yet another embodiment, the coloring oil of the present invention comprises at least one oil selected from at least one silicone oil with a viscosity of about 1000 centipoise. In yet another embodiment, the coloring oil of the present invention comprises about 0.1 vol% to about 3 vol% of at least one coloring compound per 100 vol% of the coloring oil. In yet another embodiment, the coloring oil of the present invention comprises about 0.25 vol% to about 2.5 vol% of at least one coloring compound per 100 vol% of the coloring oil. In yet another embodiment, the coloring oil of the present invention comprises about 0.5 vol% to about 2 vol% of at least one coloring compound per 100 vol% of the coloring oil. In yet another embodiment, the coloring oil of the present invention comprises at least one coloring compound that is a fluorescent acrylic composition emitting fluorescence at a wavelength of about 315 nm to about 400 nm. In yet another embodiment, the coloring oil of the present invention comprises at least one coloring compound that is a fluorescent acrylic composition emitting fluorescence at a wavelength of about 365 nm.

[0078] In another embodiment, the present invention relates to a coloring silicone oil comprising: at least one silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm. In yet another embodiment, in the coloring silicone oil of the present invention, at least one silicone oil has a viscosity of about 1000 centipoise. In yet another embodiment, the coloring silicone oil of the present invention comprises about 0.1 vol% to about 3 vol% of at least one coloring compound per 100 vol% of the coloring silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises about 0.25 vol% to about 2.5 vol% of at least one coloring compound per 100 vol% of the coloring silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises about 0.5 vol% to about 2 vol% of at least one coloring compound per 100 vol% of the coloring silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises at least one coloring compound, which is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm. In yet another embodiment, the coloring silicone oil of the present invention comprises at least one coloring compound, which is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

[0079] In another embodiment, the present invention relates to a method for calibrating and detecting silicone oil in a syringe barrel, the method comprising the steps of: (a) providing a syringe barrel with its inner surface coated with silicone oil; (b) obtaining an image of the inner surface of the silicone oil-coated syringe barrel using an imaging system capable of detecting silicone oil; and (c) determining, based on the image obtained from step (b), how the silicone oil interacts with at least one internal feature present in the syringe barrel. In yet another embodiment, the method of the present invention comprises using a colored silicone oil, wherein the colored silicone oil is formed from a combination of at least one silicone oil with a viscosity in the range of about 500 centipoise to about 1500 centipoise and at least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any two or more combinations thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm. In yet another embodiment, in the colored silicone oil of the present invention, at least one silicone oil has a viscosity of about 1000 centipoise. In yet another embodiment, the colored silicone oil of the present invention comprises about 0.1 vol% to about 3 vol% of at least one coloring compound per 100 vol% of the colored silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises about 0.25 vol% to about 2.5 vol% of at least one coloring compound per 100 vol% of the coloring silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises about 0.5 vol% to about 2 vol% of at least one coloring compound per 100 vol% of the coloring silicone oil. In yet another embodiment, the coloring silicone oil of the present invention comprises at least one coloring compound that is a fluorescent acrylic composition emitting fluorescence at a wavelength of about 315 nm to about 400 nm. In yet another embodiment, the coloring silicone oil of the present invention comprises at least one coloring compound that is a fluorescent acrylic composition emitting fluorescence at a wavelength of about 365 nm.

[0080] While this disclosure has been described as having an exemplary design, further modifications can be made to this disclosure within its spirit and scope. Therefore, this application is intended to cover any changes, uses, or modifications made to this disclosure using the general principles thereof. Furthermore, this application is intended to cover any deviations from this disclosure that are known or customary practices in the field to which this disclosure pertains and fall within the limitations of the appended claims.

Claims

1. A coloring oil, comprising: At least one oil, said oil being selected from one or more silicone oils, one or more hydrocarbon oils, or any combination of two or more thereof, said at least one oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and At least one coloring compound, said coloring compound being selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein, The at least one coloring compound emits fluorescence at a wavelength of about 100 nm to about 400 nm.

2. The coloring oil according to claim 1, wherein, The at least one oil is selected from at least one silicone oil.

3. The coloring oil according to any one of claims 1 or 2, wherein, The at least one oil is selected from at least one silicone oil with a viscosity of about 1000 centipoise.

4. The coloring oil according to any one of claims 1 to 3, wherein, The coloring oil comprises about 0.1% to about 3% of the at least one coloring compound per 100% volume of the coloring oil.

5. The coloring oil according to any one of claims 1 to 4, wherein, The coloring oil comprises about 0.25% to about 2.5% of the at least one coloring compound per 100% volume of the coloring oil.

6. The coloring oil according to any one of claims 1 to 5, wherein, The coloring oil comprises about 0.5% to about 2% of the at least one coloring compound per 100% volume of the coloring oil.

7. The coloring oil according to any one of claims 1 to 6, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

8. The coloring oil according to any one of claims 1 to 7, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

9. A coloring silicone oil, comprising: At least one silicone oil, said silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and At least one coloring compound, said coloring compound being selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein, The at least one coloring compound emits fluorescence at a wavelength of about 100 nm to about 400 nm.

10. The coloring silicone oil according to claim 9, wherein, The at least one silicone oil has a viscosity of about 1000 centipoise.

11. The coloring silicone oil according to any one of claims 9 or 10, wherein, The coloring silicone oil contains about 0.1 vol% to about 3 vol% of the at least one coloring compound per 100 vol% of the coloring silicone oil.

12. The coloring silicone oil according to any one of claims 9 to 11, wherein, The coloring silicone oil contains about 0.25% to about 2.5% of the at least one coloring compound per 100% volume of the coloring silicone oil.

13. The coloring silicone oil according to any one of claims 9 to 12, wherein, The coloring silicone oil contains about 0.5% to about 2% of the at least one coloring compound per 100% volume of the coloring silicone oil.

14. The coloring silicone oil according to any one of claims 9 to 13, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

15. The coloring silicone oil according to any one of claims 9 to 14, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

16. A method for calibrating and detecting colored silicone oil in a syringe barrel, the method comprising the following steps: (a) Provide a syringe barrel with its inner surface coated with colored silicone oil; (b) Obtaining an image of the inner surface of the syringe barrel coated with the colored silicone oil using an imaging system, wherein the imaging system is capable of detecting the colored silicone oil; as well as (c) Determine how the colored silicone oil interacts with at least one internal feature present in the syringe barrel based on the image obtained from step (b).

17. The method of claim 16, wherein, The coloring silicone oil comprises: At least one silicone oil, said silicone oil having a viscosity in the range of about 500 centipoise to about 1500 centipoise; and At least one coloring compound selected from one or more fluorescent acrylic compositions, one or more ultraviolet dyes, or any combination of two or more thereof, wherein the at least one coloring compound fluoresces at a wavelength of about 100 nm to about 400 nm.

18. The method according to any one of claims 16 or 17, wherein, The viscosity of the at least one colored silicone oil is about 1000 centipoise.

19. The method according to any one of claims 16 to 18, wherein, The coloring silicone oil contains about 0.1 vol% to about 3 vol% of the at least one coloring compound per 100 vol% of the coloring silicone oil.

20. The method according to any one of claims 16 to 19, wherein, The coloring silicone oil contains about 0.25% to about 2.5% of the at least one coloring compound per 100% volume of the coloring silicone oil.

21. The method according to any one of claims 16 to 20, wherein, The coloring silicone oil contains about 0.5% to about 2% of the at least one coloring compound per 100% volume of the coloring silicone oil.

22. The method according to any one of claims 16 to 21, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 315 nm to about 400 nm.

23. The method according to any one of claims 16 to 22, wherein, The at least one coloring compound is a fluorescent acrylic composition that fluoresces at a wavelength of about 365 nm.

Images