A kind of improving female ovary function, promote the development of follicular food composition and its preparation method and application

Abstract

This invention relates to the fields of food-medicine homologous compositions, nutritional products, and solid oral dosage form processing technology. Specifically, it discloses a food-medicine homologous composition for improving female ovarian function and promoting follicle development, its preparation method, and its applications. The composition includes flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, vitamin E raw material, niacin, folic acid, vitamin D raw material, vitamin B12 raw material, maltodextrin, microcrystalline cellulose, and magnesium stearate. In preparation, the main raw materials are formed into a basic mixture. The phytosterols, Haematococcus pluvialis powder, and vitamin raw materials are premixed with some excipients, and then the mixture is further blended with the basic granules to form a final product. The composition can be formulated into tablets, granules, capsules, or powders, and can be used to prepare oral nutritional supplements for women and oral products for improving female ovarian function.

Description

Technical Field

[0001] This invention relates to the fields of food-medicine homology compositions, nutritional products, and solid oral preparations processing technology, specifically to a food-medicine homology composition that improves female ovarian function and promotes follicle development, its preparation method, and its application. Background Technology

[0002] The ovary is an important organ of the female reproductive system, and its functional status is closely related to follicle growth and maturation, as well as the female reproductive endocrine status. The formation, growth, and maturation of female follicles is a continuous physiological process, influenced by age, nutritional status, lifestyle, endocrine status, and many other factors.

[0003] With changing lifestyles and increased attention to reproductive health among women, there is a growing number of oral nutritional products developed specifically for women's ovarian health and reproductive nutrition. Existing products typically combine one or more of the following: plant-based ingredients, protein sources, vitamins, minerals, or other nutrients, to meet the nutritional needs of women at different stages of life.

[0004] However, for composite compositions that simultaneously contain plant-derived powders, protein raw materials, phytosterols, fungal and algal raw materials, and multiple low-added vitamins, there are differences among the components in terms of addition amount, particle size, bulk density, flowability, and processing stability. If all raw materials are directly added to the mixing equipment for mixing at once, especially when low-added components such as folic acid, vitamin D raw materials, and vitamin B12 raw materials are mixed with a large amount of main powder, it is easy to increase the difficulty of controlling the content uniformity and batch-to-batch stability.

[0005] On the other hand, some solid oral products typically employ wet granulation to improve material flowability and molding properties. If low-dosage nutrient components are simultaneously involved in wet granulation and drying along with the main material, the corresponding components need to undergo granulation liquid and subsequent drying processes, potentially increasing the difficulty of controlling the stability of low-dosage components during processing. Therefore, designing a reasonable premixing, granulation, and molding sequence based on the physical properties and additive characteristics of different raw materials is a problem that needs to be considered in the industrial preparation of multi-component compositions.

[0006] While existing oral nutritional products for women have various technical solutions in terms of raw material composition and formulation, it is still necessary to provide a composition that combines plant-derived raw materials, protein-derived raw materials, fungal and algal raw materials, phytosterols, and multiple vitamins. Furthermore, it is necessary to set up a preparation process for low-added nutrient components, including segmented premixing, basic granulation, and post-addition total mixing, so that the composition can be further formulated into tablets, granules, capsules, or powders to meet the processing needs of different oral products.

[0007] Therefore, there is a need for a food-medicine homologous composition that improves female ovarian function and promotes follicle development, as well as its preparation method and application. Summary of the Invention

[0008] This invention provides a food-medicine composition that improves female ovarian function and promotes follicle development. The composition includes flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, vitamin E raw material, niacin, folic acid, vitamin D raw material, and vitamin B12 raw material.

[0009] The composition also includes maltodextrin, microcrystalline cellulose, and magnesium stearate.

[0010] Flaxseed concentrate is added to the composition as a plant-derived powdered ingredient.

[0011] Yeast powder is added to the composition as a yeast-derived powdered ingredient.

[0012] Concentrated whey protein is added to the composition as a protein source.

[0013] Cauliflower powder is a powdered raw material obtained by drying and pulverizing cauliflower.

[0014] Black soybean germ powder is a powdered raw material made primarily from black soybean germ.

[0015] Iron yam powder is a powdered raw material obtained by drying and pulverizing iron yam.

[0016] Phytosterols are added in the form of raw materials suitable for mixing with solid compositions.

[0017] Raspberry powder is a powdered raw material obtained by drying and pulverizing raspberries.

[0018] Haematococcus pluvialis powder can be a powdered raw material made from Haematococcus pluvialis, Haematococcus pluvialis oil microcapsule powder, or a powdered product containing components derived from Haematococcus pluvialis.

[0019] Golden Top Pleurotus ostreatus powder is a powdered raw material obtained by drying and pulverizing Golden Top Pleurotus ostreatus.

[0020] Vitamin E raw materials, niacin, folic acid, vitamin D raw materials, and vitamin B12 raw materials are added to the composition as vitamin nutrient components.

[0021] For vitamin E, vitamin D, and vitamin B12 raw materials, the amount of raw materials added can be determined according to their specifications and labeled content in actual production.

[0022] Maltodextrin and microcrystalline cellulose are used for filling, dispersing, and premixing of low-addition components in compositions.

[0023] Magnesium stearate is used to improve the processing properties of compositions during solid dosage form molding and can also be used as a lubricant during tableting or capsule filling.

[0024] This invention comprises a composite raw material system consisting of plant-derived raw materials, protein-derived raw materials, fungal and algal-derived raw materials, phytosterols, and vitamin-derived raw materials.

[0025] Furthermore, the composition can be formulated into tablets, granules, capsules, or powders.

[0026] The present invention also provides a method for preparing the above-mentioned food-medicine homology composition that improves female ovarian function and promotes follicle development, including the following steps.

[0027] S1, raw material pretreatment.

[0028] Cauliflower, Chinese yam, raspberry, and golden oyster mushroom were cleaned to remove impurities and raw materials that did not meet the processing requirements. They were then dried and pulverized to obtain cauliflower powder, Chinese yam powder, raspberry powder, and golden oyster mushroom powder, respectively.

[0029] The particle size of the pulverized powder should meet the requirements of subsequent mixing, granulation and molding.

[0030] S2, preparation of basic mixture.

[0031] Flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder, and golden oyster mushroom powder were weighed according to the product formula requirements and then mixed to obtain the basic mixture.

[0032] During the mixing process, conventional powder mixing equipment can be used to mix the main powder components and disperse them together.

[0033] S3, premixed trace components.

[0034] Weigh the phytosterols, Haematococcus pluvialis powder, vitamin E raw material, niacin, folic acid, vitamin D raw material, and vitamin B12 raw material separately.

[0035] Take a portion of maltodextrin and / or microcrystalline cellulose as a premix carrier, and mix the above raw materials with the premix carrier to obtain a trace component premix.

[0036] Furthermore, for niacin, folic acid, vitamin D raw materials and vitamin B12 raw materials, a stepwise equal-increment mixing method is used for premixing.

[0037] The stepwise equal-volume incremental mixing method refers to first mixing a raw material with a small amount of additive with maltodextrin and / or microcrystalline cellulose of similar mass to obtain a primary premix, and then adding maltodextrin and / or microcrystalline cellulose of similar mass to the primary premix and mixing them, thereby gradually increasing the amount of mixture materials so that the low-addition raw material is gradually and evenly dispersed in the premix carrier.

[0038] The above-mentioned stepwise premixing method can reduce the difficulty of mixing control when trace components are directly added to a large amount of main powder.

[0039] S4, Basic particle preparation.

[0040] Add some maltodextrin and microcrystalline cellulose to the basic mixture obtained in step S2, mix thoroughly, and then granulate.

[0041] When wet granulation is used, an appropriate amount of granulation liquid is added to the mixture to form a suitable soft mass, and then wet granulation is carried out.

[0042] The resulting wet granules are dried at 55–60°C to bring them to the state required for subsequent processing.

[0043] After drying, the particles are granulated to obtain basic particles.

[0044] S5, total mix.

[0045] The trace component premix obtained in step S3 is added to the base particles obtained in step S4 for mixing, and the remaining maltodextrin and microcrystalline cellulose are added for total mixing to obtain the total mixture.

[0046] By adding a premix of trace components containing vitamin raw materials after the base granules have been dried, the trace components do not have to undergo the entire wet granulation and drying process together with all the base materials.

[0047] S6, Formulation.

[0048] According to the required dosage form of the product, the total mixture obtained in step S5 is subjected to appropriate molding treatment.

[0049] When the product is in tablet form, magnesium stearate is added for final mixing, followed by tableting to obtain tablets.

[0050] When the product is in granule form, the total mixture is granulated and packaged according to the particle size and packaging requirements of the granule product to obtain granules.

[0051] When the product is in capsule form, the total mixture is mixed with magnesium stearate and then filled into capsules to obtain the capsules.

[0052] When the product is in powder form, the raw materials are mixed in the same segmented premixing method, and after the powder mixing requirements are met, they are quantitatively packaged to obtain the powder.

[0053] The present invention further provides the use of the above composition in the preparation of oral nutritional supplements for women.

[0054] The present invention further provides the use of the above composition in the preparation of oral products that improve female ovarian function.

[0055] The application refers to the preparation of corresponding oral products using the composition of the present invention, which may be in the form of tablets, granules, capsules or powders.

[0056] This invention does not involve directly performing disease diagnosis or treatment procedures on the human body.

[0057] Compared with existing processing methods that involve direct one-time mixing of multi-component powders, the present invention has at least the following technical features.

[0058] First, the present invention combines flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, and various vitamin raw materials into a composite composition, forming a multi-source raw material system in which plant-derived, protein-derived, fungal-derived, and vitamin-derived raw materials coexist.

[0059] Secondly, the present invention processes the main powder and low-added nutrient components separately. For low-added components such as folic acid, vitamin D raw materials and vitamin B12 raw materials, a step-by-step equal-increase method is used for premixing, which helps to reduce the difficulty of mixing control when low-added raw materials are directly added to a large amount of main powder.

[0060] Third, the present invention first granulates and dries the basic mixture, and then mixes the trace component premix with the basic particles, so that the trace components do not have to go through the whole wet granulation and drying process together with all the basic materials.

[0061] Fourth, the present invention can be prepared into tablets, granules, capsules or powders according to product needs, and is suitable for industrial processing using conventional food or solid dosage form production equipment.

[0062] Fifth, the composition of the present invention can be used to prepare oral nutritional supplements for women, and can also be used to prepare oral products that improve ovarian function in women, providing a compositional technical solution for the formulation and preparation development of corresponding products. Attached Figure Description

[0063] Figure 1 This is a schematic diagram of the composition of the composition; Figure 2 This is a flowchart of the composition preparation method. Detailed Implementation

[0064] The technical solution of the present invention will be further described below through specific embodiments. It should be noted that the following embodiments are mainly used to illustrate the raw material composition, premixing method, granulation method, and preparation process of different dosage forms of the compositions of the present invention. Without providing real animal or clinical trial data, these embodiments do not record fictitious follicle numbers, hormone levels, efficacy rates, or clinical efficacy values.

[0065] Example 1 A method for preparing a tablet of a food-grade medicinal composition that improves female ovarian function and promotes follicle development.

[0066] Flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower, black soybean germ powder, Chinese yam, phytosterols, raspberry, Haematococcus pluvialis, Pleurotus ostreatus, vitamin E raw material, niacin, folic acid, vitamin D raw material, vitamin B12 raw material, maltodextrin, microcrystalline cellulose and magnesium stearate were selected as raw materials for preparation.

[0067] First, the cauliflower, Chinese yam, raspberries, and golden oyster mushrooms are cleaned to remove impurities that do not meet the processing requirements. The cleaned raw materials are then dried separately.

[0068] The dried cauliflower, Chinese yam, raspberry, and golden oyster mushroom were pulverized and sieved to obtain cauliflower powder, Chinese yam powder, raspberry powder, and golden oyster mushroom powder, respectively.

[0069] According to the product formula requirements, weigh out flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder, and golden oyster mushroom powder respectively, put the above raw materials into the mixing equipment for mixing, and obtain the basic mixture.

[0070] Separately weigh out phytosterols, Haematococcus pluvialis powder, vitamin E raw material, niacin, folic acid, vitamin D raw material and vitamin B12 raw material.

[0071] First, vitamin B12 raw material is mixed with a portion of maltodextrin. Then, maltodextrin and / or microcrystalline cellulose are added in equal increments to increase the amount of premix. Next, folic acid, vitamin D raw material and niacin are added in sequence and mixed. Then, vitamin E raw material, Haematococcus pluvialis powder and phytosterols are added to obtain a trace component premix.

[0072] Add some maltodextrin and microcrystalline cellulose to the basic mixture, mix well, and then add an appropriate amount of granulation liquid to make a soft material.

[0073] The obtained soft material is subjected to wet granulation, and the resulting wet granules are dried at 55–60°C.

[0074] The dried granules are granulated to obtain basic granules.

[0075] Add the trace component premix to the base granules, then add the remaining maltodextrin and microcrystalline cellulose for total mixing.

[0076] After the total mixing is completed, magnesium stearate is added for final mixing.

[0077] The final mixed materials are compressed into tablets to obtain a food-medicine homologous composition tablet that improves female ovarian function and promotes follicle development.

[0078] Example 2 A method for preparing a granule of a food-medicine homologous composition that improves female ovarian function and promotes follicle development.

[0079] The raw materials include flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, vitamin E, niacin, folic acid, vitamin D, vitamin B12, maltodextrin, microcrystalline cellulose, and magnesium stearate.

[0080] Cauliflower powder, Chinese yam powder, raspberry powder, and golden pine mushroom powder were prepared according to the method described in Example 1.

[0081] The basic mixture is prepared by mixing flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder, and golden pine mushroom powder.

[0082] Phytosterols, Haematococcus pluvialis powder, vitamin E raw material, niacin, folic acid, vitamin D raw material and vitamin B12 raw material are premixed with a portion of maltodextrin and / or microcrystalline cellulose. The niacin, folic acid, vitamin D raw material and vitamin B12 raw material are premixed in a stepwise equal-increase manner to obtain a trace component premix.

[0083] Add some maltodextrin and microcrystalline cellulose to the basic mixture and perform wet granulation. The resulting wet granules are dried at 55-60°C.

[0084] After drying, the grains are granulated.

[0085] The trace component premix was mixed with the obtained base granules, and the remaining maltodextrin, microcrystalline cellulose and magnesium stearate were added. After being mixed evenly, the mixture was quantitatively dispensed to obtain granules.

[0086] Example 3 A method for preparing a capsule of a food-medicine homologous composition that improves female ovarian function and promotes follicle development.

[0087] Cauliflower, Chinese yam, raspberry, and golden oyster mushroom were processed according to the method described in Example 1 to obtain the corresponding powdered raw materials.

[0088] The flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder, and golden oyster mushroom powder are mixed together.

[0089] Granulation is carried out after adding some maltodextrin and microcrystalline cellulose.

[0090] The resulting wet granules were dried at 55–60°C, and the dried granules were then granulated.

[0091] In addition, phytosterols, Haematococcus pluvialis powder, vitamin E raw material, niacin, folic acid, vitamin D raw material and vitamin B12 raw material are taken, and a portion of maltodextrin and / or microcrystalline cellulose is used as a premix carrier. The low-added vitamin raw materials are mixed in a stepwise equal-increase manner to obtain a trace component premix.

[0092] Add the trace component premix to the base granules, then add the remaining maltodextrin and microcrystalline cellulose and mix.

[0093] After adding magnesium stearate, the mixture is finally mixed.

[0094] The obtained total mixture is filled into the capsule shell according to the filling volume requirements of the capsule product to obtain the capsule dosage.

[0095] Example 4 A method for preparing a powder of a medicinal and edible homologous composition that improves female ovarian function and promotes follicle development.

[0096] This embodiment uses flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, vitamin E raw material, niacin, folic acid, vitamin D raw material, vitamin B12 raw material, maltodextrin, microcrystalline cellulose, and magnesium stearate.

[0097] The main powder is prepared by mixing flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder, and golden pine mushroom powder.

[0098] Vitamin B12, folic acid, vitamin D, and niacin were premixed with maltodextrin and / or microcrystalline cellulose in a stepwise, equal-increase manner. Then, phytosterols, Haematococcus pluvialis powder, and vitamin E were added to obtain a trace component premix.

[0099] The trace component premix was gradually added to the main powder and mixed, followed by the addition of the remaining maltodextrin, microcrystalline cellulose and magnesium stearate and continued mixing.

[0100] Once the raw materials are mixed to meet the product processing requirements, they are quantitatively packaged according to the product packaging specifications to obtain powder.

[0101] Example 5 Different methods of implementing Haematococcus pluvialis raw materials.

[0102] The composition and other preparation steps of this embodiment are the same as those of Example 1, except that the raw material for Haematococcus pluvialis is Haematococcus pluvialis powder.

[0103] In another embodiment, the raw material from Haematococcus pluvialis is Haematococcus pluvialis oil microcapsule powder.

[0104] In another embodiment, the raw material from Haematococcus pluvialis is a powdered product containing Haematococcus pluvialis-derived components.

[0105] The above-mentioned Haematococcus pluvialis raw materials are premixed with a portion of maltodextrin and / or microcrystalline cellulose before being added to the base particles, and then combined with other trace components to form a trace component premix.

[0106] Example 6 An implementation method of gradually increasing the amount of premixed material.

[0107] Take vitamin B12 as the initial low-addition raw material, and add maltodextrin and / or microcrystalline cellulose in proportion to its quality for the first mixing.

[0108] After the first mixing is completed, add maltodextrin and / or microcrystalline cellulose in proportion to the mass of the resulting mixture and continue mixing.

[0109] The premixed carrier is added sequentially in the manner described above.

[0110] After the vitamin B12 raw material is fully dispersed, folic acid, vitamin D raw material and niacin are introduced in sequence and mixed in the same stepwise expansion manner.

[0111] Subsequently, vitamin E raw materials, Haematococcus pluvialis powder, and phytosterols were added and mixed to obtain a trace component premix for use in the overall mixing with the base particles.

[0112] By using the above method, relatively low amounts of nutrient components are first dispersed in a small amount of premixed carrier, and then the amount of premix is ​​gradually increased to meet the needs of subsequent total mixing with base particles.

[0113] Example 7 The application of the composition of the present invention in the preparation of oral nutritional supplements for women.

[0114] The food-medicine homology composition of the present invention was obtained according to any one of Examples 1 to 6.

[0115] Depending on the use and packaging of the different products, the composition may be formulated into one of the following: tablets, granules, capsules, or powder.

[0116] The resulting solid oral composition is used as an oral nutritional supplement for women to form a compound oral product containing plant-derived nutritional ingredients, protein-derived ingredients, fungal and algal-derived ingredients, phytosterols, and vitamins.

[0117] This embodiment is used to illustrate the product preparation use of the composition of the present invention and does not involve the direct implementation of disease diagnosis or treatment methods on the human body.

[0118] Example 8 The use of the composition of the present invention in the preparation of oral products that improve female ovarian function.

[0119] The composition was prepared according to any one of Examples 1 to 6.

[0120] The composition may be formulated into tablets, granules, capsules or powder according to the product dosage form requirements.

[0121] The resulting composition is used to prepare oral products for improving female ovarian function.

[0122] In the specific product preparation process, the amount of raw materials to be added can be calculated according to the actual specifications of the vitamin E, vitamin D and vitamin B12 raw materials used, so that the final product meets the predetermined formula and processing requirements.

[0123] Since this application does not use unverified data to illustrate specific hormone indicators, changes in follicle count, or human efficacy rates, this embodiment only describes the preparation, use, and product form of the composition.

[0124] The above embodiments are used to illustrate the technical solution of the present invention. Those skilled in the art can make conventional adjustments to the mixing time, granulation equipment, granulation method, and molding conditions based on the disclosure in this specification, according to the required dosage form. As long as the corresponding adjustments do not change the main composition of the composition of the present invention or the technical concept of premixing the main raw materials and trace components separately, they can all be used to implement the present invention.

[0125] The compositions of the present invention can be prepared using conventional powder mixing equipment, wet granulation equipment, drying equipment, sizing equipment, tableting equipment, capsule filling equipment, and powder packaging equipment, and are suitable for industrial manufacturing and use.

[0126] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely illustrative of the principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the present invention as claimed. The scope of protection of this invention is defined by the appended claims and their equivalents.

Claims

1. A medicinal and edible homologous composition for improving female ovarian function and promoting follicle development, its preparation method and application, characterized in that, The composition includes flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, phytosterols, raspberry powder, Haematococcus pluvialis powder, Pleurotus ostreatus powder, vitamin E raw material, niacin, folic acid, vitamin D raw material and vitamin B12 raw material, and also includes maltodextrin, microcrystalline cellulose and magnesium stearate.

2. The medicinal and edible homologous composition for improving female ovarian function and promoting follicle development according to claim 1, its preparation method and application, characterized in that, The cauliflower powder is a powdered raw material obtained by drying and pulverizing cauliflower; the Chinese yam powder is a powdered raw material obtained by drying and pulverizing Chinese yam; the raspberry powder is a powdered raw material obtained by drying and pulverizing raspberry; and the golden pine ear powder is a powdered raw material obtained by drying and pulverizing golden pine ear.

3. The medicinal and edible homologous composition for improving female ovarian function and promoting follicle development according to claim 1, its preparation method and application, characterized in that, The Haematococcus pluvialis powder is a powdered raw material made from Haematococcus pluvialis, Haematococcus pluvialis oil microcapsule powder, or a powdered product containing components derived from Haematococcus pluvialis.

4. The medicinal and edible homologous composition for improving female ovarian function and promoting follicle development according to claim 1, its preparation method and application, characterized in that, The maltodextrin and microcrystalline cellulose serve as fillers and premixed carriers, while the magnesium stearate serves as a lubricant.

5. The medicinal and edible composition for improving female ovarian function and promoting follicle development according to any one of claims 1 to 4, its preparation method and application, characterized in that, The composition is in the form of tablets, granules, capsules, or powder.

6. A medicinal and edible composition for improving female ovarian function and promoting follicle development as described in any one of claims 1 to 5, a method for preparing the same, and its application, characterized in that, Includes the following steps: S1, cauliflower, Chinese yam, raspberry and golden top pine mushroom are cleaned, dried and pulverized respectively to obtain cauliflower powder, Chinese yam powder, raspberry powder and golden top pine mushroom powder. S2, mix flaxseed concentrate, yeast powder, whey protein concentrate, cauliflower powder, black soybean germ powder, Chinese yam powder, raspberry powder and golden pine mushroom powder to obtain the basic mixture; S3, phytosterols, Haematococcus pluvialis powder, vitamin E raw material, niacin, folic acid, vitamin D raw material and vitamin B12 raw material are premixed with a portion of maltodextrin and / or microcrystalline cellulose to obtain a trace component premix; S4, the basic mixture is mixed with a portion of maltodextrin and microcrystalline cellulose, and then granulated and dried to obtain basic granules; S5, the trace component premix is ​​mixed with the base particles, and the remaining maltodextrin and microcrystalline cellulose are added to obtain the total mixture. S6. The total mixture is shaped according to the desired dosage form to obtain a food-medicine homologous composition that improves female ovarian function and promotes follicle development.

7. The medicinal and edible composition for improving female ovarian function and promoting follicle development according to claim 6, its preparation method and application, characterized in that, In step S3, niacin, folic acid, vitamin D raw materials and vitamin B12 raw materials are premixed with maltodextrin and / or microcrystalline cellulose using a stepwise equal-increase mixing method.

8. The medicinal and edible composition for improving female ovarian function and promoting follicle development according to claim 6, its preparation method and application, characterized in that, Step S4 uses wet granulation, and the resulting wet granules are dried at 55-60℃ and then granulated.

9. The medicinal and edible composition for improving female ovarian function and promoting follicle development according to any one of claims 1 to 5, its preparation method and application, characterized in that, The composition is used to prepare oral nutritional supplements for women.

10. The medicinal and edible composition for improving female ovarian function and promoting follicle development according to any one of claims 1 to 5, and its preparation method and application, characterized in that, The composition is used to prepare oral products that improve female ovarian function.

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