A continuous production device for concentrated liquid medicine

Abstract

This invention discloses a continuous pharmaceutical liquid concentration production apparatus, relating to the field of pharmaceutical liquid production. It includes a shell for providing a separation space, with an inlet, an outlet, and a drain outlet. A sealing element is slidably disposed inside the shell. A liquid-blocking plate is rotatably disposed inside the shell, with a through-hole allowing liquid to pass through. A sealing plate adapted to the through-hole is disposed below the liquid-blocking plate. When the sealing element opens the drain outlet, the sealing plate seals the through-hole. In this continuous pharmaceutical liquid concentration production apparatus, when draining is not required, the solid portion of the sealing plate is offset from the through-hole, allowing the isolated liquid to fall onto the liquid-blocking plate and then through the through-hole to a storage area for accumulated liquid. When draining is required, rotating the liquid-blocking plate seals the through-hole, separating the storage area from the space above the liquid-blocking plate to minimize gas leakage from the drain outlet.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical liquid production, and more specifically to a continuous pharmaceutical liquid concentration production apparatus. Background Technology

[0002] As is known, the production of Sophora japonica extract (rhamnose) includes the following processes: filtrate, concentration, filtration, crystallization, centrifugation, dissolution, filtration, concentration, crystallization, centrifugation, drying, pulverization, and sieving. In the concentration step, a single-effect concentrator is required. The single-effect concentrator includes an evaporation chamber and a condenser, and a gas-liquid separator is installed between the two to remove liquid substances contained in the gas.

[0003] For example, the Chinese patent document with authorization announcement number CN206045433U, announcement date of 2017-03-29, and titled "A Low-Temperature Single-Effect Concentrator," includes a single-effect concentrator body. The single-effect concentrator body includes a heater, a heat exchange device, and a circulating water tank. A process water pipeline is connected to the cold liquid inlet of the heat exchange device, the hot liquid outlet of the heat exchange device is connected to the liquid inlet of the circulating water tank, the liquid outlet of the circulating water tank is connected to the shell-side liquid inlet of the heater, and the shell-side liquid outlet of the heater is connected to the liquid inlet of the circulating water tank. This low-temperature single-effect concentrator has a simple structure, can achieve low-temperature concentration of various products, effectively avoids the loss of components that are easily oxidized and decomposed at high temperatures, effectively protects against the loss of volatile components, and improves the actual yield of effective components in the product, thereby greatly saving product production costs.

[0004] The shortcoming of the existing technology is that when there is too much liquid at the bottom of the gas-liquid separator, in order to avoid the liquid being carried away by the gas again, it is usually discharged through the drain pipe at the bottom when the liquid level is high. However, during the liquid discharge process, since the liquid is connected to the space inside the separator, some gas is prone to "escape" with the liquid, resulting in waste of the liquid. Summary of the Invention

[0005] The purpose of this invention is to provide a continuous production apparatus for drug concentration to overcome the above-mentioned shortcomings in the prior art.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] A continuous production apparatus for concentrating pharmaceutical solutions includes a shell for providing a separation space, wherein the shell is provided with an inlet, an outlet and a drain outlet, and a sealing element is slidably disposed inside the shell;

[0008] A liquid-blocking plate is rotatably disposed inside the housing. The liquid-blocking plate is provided with a through hole for liquid to pass through. A sealing plate adapted to the through hole is disposed below the liquid-blocking plate. When the sealing member opens the drain port, the sealing plate seals the through hole.

[0009] The above-mentioned continuous production device for drug liquid concentration includes a separation cylinder inside the shell, and a spiral blade and a partition are provided between the outer circumferential surface of the separation cylinder and the inner wall of the shell. The area between the spiral blade and the partition is the primary separation zone.

[0010] In the above-mentioned continuous production device for drug concentration, the partition is arranged at an inclination, and the end of the partition near the discharge port is lower than the discharge port. The upper part of the partition is a secondary separation zone. A channel is opened inside the side wall of the shell. One end of the channel is connected to the secondary separation zone, and the other end is connected to the through hole.

[0011] In the aforementioned continuous production apparatus for drug liquid concentration, a transmission rod is fixedly connected to the liquid shielding plate, a transmission part is provided on the transmission rod, a transmission groove is provided on the transmission part, and a sliding rod is fixedly connected to the sealing member, with the sliding rod slidably connected to the transmission groove.

[0012] In the aforementioned continuous production device for drug liquid concentration, the transmission part is provided with an inclined surface.

[0013] In the aforementioned continuous production device for drug liquid concentration, the transmission tank is wave-shaped.

[0014] The aforementioned continuous production apparatus for drug liquid concentration also includes a venting component on the liquid shielding plate for accelerating the discharge of accumulated liquid.

[0015] The above-mentioned continuous production apparatus for drug concentration includes a venting component comprising a connecting pipe fixed to the side wall of the housing, the connecting pipe having multiple air holes, a first perforated plate on the transmission rod, and a second perforated plate adapted to the first perforated plate on the connecting pipe. The first perforated plate has a first position for blocking the second perforated plate and a second position for opening the second perforated plate.

[0016] In the aforementioned continuous production device for drug concentration, a reinforcing rod is provided on the connecting pipe.

[0017] In the aforementioned continuous production apparatus for drug liquid concentration, the liquid shielding plate is provided with multiple triangular protrusions.

[0018] In the above technical solution, the present invention provides a continuous production device for drug liquid concentration, in which a liquid shielding plate is rotatably arranged inside the shell, and multiple through holes are opened on the liquid shielding plate. A sealing plate adapted to the through holes is arranged below the liquid shielding plate. When liquid drainage is not required, the solid part of the sealing plate is offset from the through holes, and the isolated liquid falls onto the liquid shielding plate and falls into the liquid storage area through the through holes. When the liquid needs to be drained, the liquid shielding plate is rotated to seal the through holes, so that the storage area is separated from the space above the liquid shielding plate, so as to minimize the gas from being discharged from the drain port. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments recorded in this invention. For those skilled in the art, other drawings can be obtained based on these drawings.

[0020] Figure 1 This is a schematic diagram of the external structure provided in an embodiment of the present invention;

[0021] Figure 2 This is a cross-sectional structural diagram provided for an embodiment of the present invention;

[0022] Figure 3 for Figure 2 Enlarged schematic diagram of a local structure at point A;

[0023] Figure 4 for Figure 2 Enlarged schematic diagram of the local structure at point B;

[0024] Figure 5 A schematic diagram of the working process of the slide bar and transmission groove provided in another embodiment of the present invention (wherein, the transmission part is in the unfolded state).

[0025] Figure 6 This is a partial cross-sectional structural schematic diagram provided in another embodiment of the present invention;

[0026] Figure 7 This is a schematic diagram of the overall structure of the liquid shielding plate provided in another embodiment of the present invention.

[0027] Explanation of reference numerals in the attached figures:

[0028] 1. Shell; 2. Inlet; 3. Outlet; 4. Drain; 5. Sealing component; 6. Liquid shield; 7. Sealing plate; 8. Separation cylinder; 9. Spiral blade; 10. Partition; 11. Primary separation zone; 12. Secondary separation zone; 13. Channel; 14. Transmission rod; 15. Transmission part; 16. Transmission groove; 17. Slide rod; 18. Connecting groove; 19. Connecting pipe; 20. Air hole; 21. First perforated plate; 22. Second perforated plate; 23. Reinforcing rod; 24. Triangular protrusion; 25. Sliding seat; 26. Impact rod; 27. Through hole. Detailed Implementation

[0029] To enable those skilled in the art to better understand the technical solution of the present invention, the present invention will be further described in detail below with reference to the accompanying drawings.

[0030] In the description of this invention, it should be understood that, Figure 2 The position of the partition plate 10 relative to the spiral blade 9 is upper, and vice versa. The terms "center", "longitudinal", "lateral", "length", "width", "degree", "upper", "lower", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "radial", "circumferential" and other indications of orientation or positional relationship are based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present invention.

[0031] Reference Figure 1-7 The present invention provides a continuous production device for drug liquid concentration, including a shell 1 for providing a separation space, wherein the shell 1 is provided with a feed inlet 2, a discharge outlet 3 and a drain outlet 4, and a sealing member 5 is slidably disposed inside the shell 1;

[0032] A liquid shielding plate 6 is rotatably disposed inside the housing 1. The liquid shielding plate 6 is provided with a through hole 27 for liquid to pass through. A sealing plate 7 adapted to the through hole 27 is provided below the liquid shielding plate 6. When the sealing member 5 opens the drain port 4, the sealing plate 7 seals the through hole 27.

[0033] Specifically, the shell 1 is approximately a hollow ellipsoidal structure. The inlet 2 and outlet 3 are symmetrically arranged about the shell 1. The drain outlet 4 is located at the bottom of the shell 1. The liquid shielding plate 6 is approximately an arc-shaped plate, located near the bottom of the shell 1. Above the liquid shielding plate 6 is a gas-liquid separation zone, and below the liquid shielding plate 6 is a liquid storage zone. The gas-liquid separation zone and the storage zone are connected by multiple through holes 27. During gas-liquid separation, the gas-liquid mixture enters the gas-liquid separation zone to separate the gas and liquid. The separated liquid enters the storage zone through the through holes 27, and the separated gas... The material is discharged from outlet 3 and enters the condenser for cooling. This is existing technology and will not be elaborated upon. One of the core innovations of this invention is that the liquid shielding plate 6 is rotatably installed inside the housing 1. That is, an annular groove is provided on the inner wall of the housing 1, and the edge of the liquid shielding plate 6 is rotatably connected to the annular groove. A sealing plate 7 adapted to the through hole 27 is fixedly attached below the liquid shielding plate 6, and the sealing plate 7 fits against the liquid shielding plate 6. The sealing member 5 is set inside the storage area, and its bottom is an inverted frustum shape. The radial dimension of the frustum bottom is smaller than the radial dimension of the drain port 4. The radial dimension of the top is larger than the radial dimension of the drain port 4, meaning that the sealing element 5 can be partially inserted into the drain port 4. When the outer circumferential surface of the sealing element 5 is in contact with the edge of the drain port 4, the drain port 4 can be sealed. The vertical movement of the sealing element 5 can be controlled by a linear reciprocating drive structure such as an electric push rod (not shown; the sealing element 5 is fixed to the output shaft of the reciprocating drive structure, and the output shaft can be circumferentially limited by a limit bar or other structure, preventing the output shaft from rotating; details omitted). This configuration is intended to allow for the opening and closing of the drain port 4 when drainage is not required. The sealing element 5 is inserted into the drain port 4 to block the drain port 4. At this time, the solid part of the sealing plate 7 is offset from the through hole 27. The separated liquid falls onto the liquid shielding plate 6 and falls into the liquid storage area through the through hole 27. When the liquid level gauge (not shown) detects that the liquid level in the storage area is high and the liquid needs to be drained, the sealing element 5 is controlled to move upward so that the drain port 4 can be opened. At the same time, the liquid shielding plate 6 is rotated to block the through hole 27, so that the storage area is separated from the space above the liquid shielding plate 6 to prevent gas from being discharged from the drain port 4 as much as possible.

[0034] Furthermore, a separation cylinder 8 is provided inside the housing 1. A spiral blade 9 and a partition 10 are arranged between the outer circumference of the separation cylinder 8 and the inner wall of the housing 1. The area between the spiral blade 9 and the partition 10 is the primary separation zone 11. This arrangement allows the gas-liquid mixture to enter the primary separation zone 11 from the inlet 2, preferentially impacting the outer wall of the separation cylinder 8 to achieve gas-liquid separation. The separated gas moves downwards along the spiral blade 9 to increase the gas-liquid separation time, then moves upwards through the separation cylinder 8 and is finally discharged from the outlet 3. The separated liquid falls onto the spiral blade 9, slides down along the spiral blade 9 onto the liquid shield 6, and then falls into the storage area through the through-hole 27.

[0035] Preferably, the partition 10 is arranged at an angle, and the end of the partition 10 near the discharge port 3 is lower than the discharge port 3. The upper part of the partition 10 is a secondary separation zone 12. A channel 13 is opened inside the side wall of the shell 1. One end of the channel 13 is connected to the secondary separation zone 12, and the other end is connected to the through hole 27. The purpose of this arrangement is that the gas rising inside the separation cylinder 8 will collide with the inner top wall of the shell 1 to achieve secondary gas-liquid separation. Part of the liquid produced after separation will fall onto the liquid shielding plate 6 through the separation cylinder 8 for collection, and the other part will fall into the storage area through the channel 13 and the through hole 27 for unified storage.

[0036] Preferably, a transmission rod 14 is fixedly connected to the liquid shielding plate 6, a transmission part 15 is provided on the transmission rod 14, a transmission groove 16 is provided on the transmission part 15, and a sliding rod 17 is fixedly connected to the sealing member 5, with the sliding rod 17 slidably connected to the transmission groove 16. Specifically, the transmission part 15 is provided with a connecting groove 18, and the sealing member 5 is slidably and sealingly connected to the connecting groove 18. The slide rod 17 is preferably a cylindrical rod, and there are two of them. The two slide rods 17 are symmetrically arranged about the sealing member 5. Similarly, there are two transmission grooves 16, which are arranged correspondingly about the position of the slide rods 17. The purpose of this arrangement is that when the sealing member 5 moves to control the opening of the drain port 4, it will drive the slide rod 17 to slide along the transmission groove 16. Since the transmission groove 16 is inclined along the inner circumference of the connecting groove 18, the transmission part 15, the transmission rod 14 and the liquid shielding plate 6 can be rotated when the slide rod 17 slides along the transmission groove 16. This causes the through hole 27 to coincide with the solid part of the sealing plate 7. In this way, when the drain port 4 is opened, the through hole 27 is passively blocked. When the accumulated liquid is discharged, the sealing member 5 is controlled to move downward, thereby driving the slide rod 17 to slide in the opposite direction in the transmission groove 16, so as to drive the liquid shielding plate 6 to rotate in the opposite direction, thereby passively opening the through hole 27.

[0037] Preferably, the transmission part 15 is provided with an inclined surface. The inclined surface is provided on the upper surface of the sealing member 5 to minimize the accumulation of liquid above the sealing member 5 during the drainage process.

[0038] It should be noted that, since the positions of the spiral blade 9 and the separating cylinder 8 are fixed, the droplets fall onto the liquid shield 6 at almost the same position, which easily causes localized wear on the liquid shield 6. To solve the above problem, as another embodiment of the present invention, the transmission groove 16 is wave-shaped. Specifically, the transmission groove 16 is formed on the inner circumferential surface of the transmission part 15, and it is approximately wave-shaped. The width of the transmission groove 16 is greater than the radial dimension of the slide bar 17. The inner walls on both sides of the crest of the transmission groove 16 are staggered, and the inner walls on both sides of the trough are also staggered, such as... Figure 5 As shown, the purpose of this arrangement is that during the vertical movement of the sealing component 5, it will drive the sliding rod 17 to move vertically. Since the sealing component 5 cannot rotate, when the sliding rod 17 comes into contact with the crest or trough of the transmission groove 16 at a misaligned position, the transmission part 15, the transmission rod 14, and the liquid shielding plate 6 will rotate to block the through hole 27. At this time, the sliding rod 17 moves into the trough or crest, so that the transmission part 15 cannot continue to rotate, thereby fixing the position of the liquid shielding plate 6. After the liquid is drained, the sealing component 5 is controlled to move downward, thereby driving the sliding rod 17 to move downward synchronously, so that the sliding rod 17 comes into contact with the inclined part near another crest. This process is repeated, so that the liquid shielding plate 6 can be rotated in one direction during the process of the sealing component 5 controlling the opening and closing of the drain port 4, thereby switching the area for receiving liquid droplets and minimizing local wear of the liquid shielding plate 6.

[0039] Furthermore, the liquid shield 6 is also provided with a venting component for accelerating the discharge of accumulated liquid.

[0040] Preferably, the venting assembly includes a connecting pipe 19 fixed to the side wall of the housing 1, the connecting pipe 19 having a plurality of air holes 20, the transmission rod 14 having a first perforated plate 21, the connecting pipe 19 having a second perforated plate 22 adapted to the first perforated plate 21, the first perforated plate 21 having a first position for blocking the second perforated plate 22 and a second position for opening the second perforated plate 22. Specifically, the connecting pipe 19 is L-shaped, comprising a horizontal section and a vertical section. The horizontal section extends through the side wall of the housing 1 into the storage area and is fixedly connected to the housing 1. The horizontal section can be connected to a storage tank (not shown) containing inert gases such as nitrogen. Air vents 20 are located on the vertical section, near the upwardly recessed position of the liquid-shielding plate 6. Multiple air vents 20 are arranged in a circular array on the vertical section. The transmission rod 14 penetrates the side wall of the connecting pipe 19 and is fixedly connected to the liquid-shielding plate 6. The first perforated plate 21 is fixedly connected to the outer circumferential surface of the transmission rod 14, and the second perforated plate 22 is fixedly connected to the inner wall of the connecting pipe 19. The holes on the first perforated plate 21 and the second perforated plate 22 are compatible, and both the first perforated plate 21 and the second perforated plate 22 are placed in the vertical section. This arrangement ensures that when the sealing component 5 is in the sealing position... The holes on the first perforated plate 21 and the second perforated plate 22 are completely misaligned (this is the first position of the first perforated plate 21). At this time, the gas inside the storage tank cannot enter the storage area. When drainage is required, the sealing element 5 will drive the transmission rod 14 to rotate, thereby driving the first perforated plate 21 to rotate synchronously. When the holes on the first perforated plate 21 and the second perforated plate 22 coincide (this is the second position of the first perforated plate 21), the gas inside the storage tank can enter between the liquid surface of the accumulated liquid and the lower surface of the liquid shielding plate 6, thereby balancing the gas pressure inside the storage area and the outside, so as to accelerate the drainage of the accumulated liquid. After the drainage is completed, the sealing element 5 moves down, thereby driving the transmission rod 14 to continue to rotate, so that the holes on the first perforated plate 21 and the second perforated plate 22 are misaligned, so as to seal the connecting pipe 19 again.

[0041] Furthermore, the connecting pipe 19 is provided with reinforcing rods 23. Specifically, there are multiple reinforcing rods 23, which are arranged in a ring array on the outer surface of the connecting pipe 19. The end of the reinforcing rod away from the connecting pipe 19 is fixed to the sealing plate 7, thereby improving the stability of the connecting pipe 19 during installation.

[0042] In another embodiment of the present invention, the liquid-blocking plate 6 is provided with a plurality of triangular protrusions 24. Specifically, the cross-section of the liquid-blocking plate 6 is arc-shaped, and an annular portion is provided around it. The triangular protrusions 24 are provided on the upper surface of the solid portion of the annular portion, that is, the two lower ends of the triangular protrusions 24 are close to two adjacent through holes 27 respectively. The purpose of this arrangement is that the triangular protrusions 24 play a guiding role. When liquid falls on the triangular protrusions 24, its inclined surface can guide the liquid to the position of the through hole 27 and fall into the storage area, thereby minimizing the accumulation of liquid on the annular portion.

[0043] Preferably, a sliding seat 25 and an impact rod 26 slidably disposed on the sliding seat 25 are fixedly connected inside the housing 1. The bottom of the impact rod 26 is located on the movement stroke of the triangular protrusion 24. Specifically, the sliding seat 25 is fixed to the side wall of the housing 1 and is annular. The impact rod 26 is cylindrical, and the radial dimension of the impact rod 26 above the sliding seat 25 is larger than the radial dimension inside the sliding seat 25, so as to limit the vertical movement of the impact rod 26 and prevent it from moving excessively downward. The top of the impact rod 26 is located below the spiral blade 9 and close to the spiral blade 9. The purpose of this arrangement is that when the sealing member 5 controls the opening and closing of the drain port 4, it will drive the liquid shielding plate 6 to rotate, thereby synchronously driving the triangular protrusion on its surface. The triangular protrusion 24 rotates synchronously. During the rotation of the triangular protrusion 24, it will abut against the bottom of the impact rod 26, thereby pushing the impact rod 26 to move upward so that the top of the impact rod 26 will collide with the spiral blade 9. This will cause the spiral blade 9 and the separation cylinder 8 to vibrate, shaking off the droplets attached to their surfaces. This can minimize the secondary carry-out of droplets on the spiral blade 9 and the separation cylinder 8. After the impact is completed, the impact rod 26 moves downward under its own gravity to reset. This process can be repeated to achieve multiple impacts of the spiral blade 9.

[0044] The foregoing has only described certain exemplary embodiments of the present invention by way of illustration. Undoubtedly, those skilled in the art can modify the described embodiments in various ways without departing from the spirit and scope of the present invention. Therefore, the foregoing drawings and descriptions are illustrative in nature and should not be construed as limiting the scope of protection of the claims of the present invention.

Claims

1. A continuous production apparatus for concentrating pharmaceutical solutions, comprising a shell for providing a separation space, the shell being provided with an inlet, an outlet, and a drain outlet, characterized in that, A sealing element is slidably disposed inside the housing; A liquid-blocking plate is rotatably disposed inside the housing. The liquid-blocking plate is provided with a through hole for liquid to pass through. A sealing plate adapted to the through hole is disposed below the liquid-blocking plate. When the sealing member opens the drain port, the sealing plate seals the through hole.

2. The continuous production apparatus for drug liquid concentration according to claim 1, characterized in that, The shell contains a separation cylinder, and a spiral blade and a partition are provided between the outer circumference of the separation cylinder and the inner wall of the shell. The area between the spiral blade and the partition is the primary separation zone.

3. The continuous production apparatus for drug liquid concentration according to claim 2, characterized in that, The partition is arranged at an angle, and the end of the partition near the discharge port is lower than the discharge port. The area above the partition is a secondary separation zone. A channel is opened inside the side wall of the shell. One end of the channel is connected to the secondary separation zone, and the other end is connected to the through hole.

4. The continuous production apparatus for drug liquid concentration according to claim 1, characterized in that, A transmission rod is fixedly connected to the liquid shielding plate. A transmission part is provided on the transmission rod. A transmission groove is provided on the transmission part. A sliding rod is fixedly connected to the sealing member. The sliding rod is slidably connected to the transmission groove.

5. The continuous production apparatus for drug liquid concentration according to claim 4, characterized in that, The transmission part is provided with an inclined surface.

6. The continuous production apparatus for drug liquid concentration according to claim 4, characterized in that, The transmission groove is wave-shaped.

7. The continuous production apparatus for drug liquid concentration according to claim 4, characterized in that, The liquid shield is also equipped with a venting component to accelerate the drainage of accumulated liquid.

8. The continuous production apparatus for drug liquid concentration according to claim 7, characterized in that, The venting assembly includes a connecting pipe fixed to the side wall of the housing, the connecting pipe having multiple air holes, a first perforated plate on the transmission rod, and a second perforated plate adapted to the first perforated plate on the connecting pipe. The first perforated plate has a first position for blocking the second perforated plate and a second position for opening the second perforated plate.

9. A continuous production apparatus for drug liquid concentration according to claim 8, characterized in that, The connecting pipe is equipped with a reinforcing rod.

10. A continuous production apparatus for drug liquid concentration according to claim 1, characterized in that, The liquid shielding plate is provided with multiple triangular protrusions.

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