Rotary tablet press for producing ilaprazole

Abstract

This invention relates to the field of pharmaceutical equipment technology, and more particularly to a rotary tableting device for the production of elastosteroids. The device includes a mounting base, with a set of baffles fixedly mounted on both sides of the top of the mounting base. A rotary tableting mechanism is rotatably mounted in the center of the mounting base. The device also includes an adjustment structure positioned between the tops of the two sets of baffles, with the bottom surface of the adjustment structure able to fit against the rotary tableting mechanism. A discharge platform is fixedly mounted on one side of the mounting base, and a discharge trough is fixedly mounted on one side of the top of the discharge platform, with the other end of the discharge trough fitting against the rotary tableting mechanism. A discharge assembly is located inside the discharge platform, and a collection trough is located on the side of the discharge platform closest to the discharge assembly. This invention effectively improves tablet weight stability and production efficiency by adjusting the tableting pressure in real time through the adjustment structure and by using the discharge assembly for online detection and sorting.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical equipment technology, and in particular to a rotary tableting device for the production of ipramazole. Background Technology

[0002] Isomeprazole enteric-coated tablets are a proton pump inhibitor commonly used clinically to treat gastric ulcers, duodenal ulcers, and reflux esophagitis. This product is typically sold in 5mg tablets, a low dosage, and requires strict quality control regarding tablet weight variation, content uniformity, hardness, friability, and disintegration time. Tableting is a critical step in the production of iriprazole enteric-coated tablets, and its quality directly affects subsequent coating processes and the quality of the finished product. Therefore, a rotary tableting device suitable for iriprazole production is needed to ensure stable tableting, controllable tablet weight, and timely removal of defective tablets.

[0003] Existing rotary tableting devices typically include a mounting base, a rotary tableting mechanism, a feeding mechanism, pressure rollers, and a discharge chute. During operation, the rotary tableting mechanism drives the die to rotate, material is fed into the die hole by the feeding mechanism, and then pressed by the pressure rollers. The formed tablets are discharged through the discharge chute. Some existing devices have visual inspection or weighing sampling modules at the discharge port, but the inspection results are usually only used for rejection or recording and are not linked to parameters such as tableting pressure and guide roller position for adjustment.

[0004] The applicant discovered during the implementation of the prior art that the prior art does not have an online visual recognition and weighing linkage feedback adjustment structure at the discharge port. Therefore, it is impossible to adjust the position of the guide wheel and the tableting pressure in real time according to the appearance and weight of the tablets during the tableting process. This results in the inability to correct issues such as tablet cracking, sticking, and tablet weight differences in a timely manner, reducing the practicality of the device.

[0005] Therefore, we propose a rotary tableting device for the production of ipramazole to solve the above problems. Summary of the Invention

[0006] The purpose of this invention is to provide a rotary tableting device for the production of ipramazole, which solves the problem in the prior art that the tableting device cannot adjust the tableting pressure in real time according to the quality of the output tablets, resulting in tablet weight differences and tablet breakage that cannot be corrected in time.

[0007] To achieve the above objectives, the present invention adopts the following technical solution: A rotary tableting device for esomeprazole production includes a mounting base, a controller disposed on one side of the front of the mounting base, a set of baffles fixedly mounted on both sides of the top of the mounting base, a rotary tableting mechanism rotatably mounted in the center of the interior of the mounting base, and a temperature and humidity sensor disposed on the side of the mounting base near the rotary tableting mechanism, the temperature and humidity sensor being electrically connected to the controller, and further includes: An adjustment structure is provided between the top ends of the two sets of baffles, and the bottom surface of the adjustment structure can fit together with the rotary tablet pressing mechanism; A discharge platform is fixedly installed on one side of the mounting base, and a discharge trough is fixedly installed on the top side of the discharge platform. The other end of the discharge trough is attached to the rotary tablet pressing mechanism. A discharge component is provided inside the discharge platform, and a collection trough is provided on the side of the discharge platform near the discharge component.

[0008] A first motor is fixedly installed on one side inside the mounting base, and a drive wheel is fixedly installed on the output end of the first motor; The bottom end of the rotary tablet pressing mechanism is fixedly equipped with a pulley, and the pulley and the drive wheel are connected together by a toothed belt.

[0009] The adjustment structure includes a guide wheel and a fixed rod. A set of sliding grooves is fixedly installed on both sides of the two sets of baffles, and a set of fixed rods is slidably installed between the two sets of sliding grooves. A guide wheel is fixedly installed on one side of the fixed rod. A first threaded screw is threadedly installed on one side of the fixing rod, and the first threaded screw is rotatably installed inside the groove of the baffle. A second motor is fixedly installed on the side of the baffle near the first threaded screw, and the output end of the second motor is fixedly installed together with the first threaded screw.

[0010] An installation platform is fixedly installed on the side of the mounting base near the rotating tableting mechanism, and a feeding trough is fixedly installed on the top of the installation platform. A discharge funnel is provided at the bottom of the feeding trough. A pneumatic push rod is fixedly installed on one side of the mounting platform, and an annular push plate is fixedly installed on the other end of the pneumatic push rod. One side of the pneumatic push rod is connected to an external air source.

[0011] A visual recognition module is fixedly installed on the side of the discharge platform near the discharge chute, and the bottom surface of the visual recognition module faces the side of the discharge chute. An opening is provided on one side of the discharge trough, and an air nozzle is fixedly installed on the side of the discharge trough away from the opening. The other end of the air nozzle is connected to an external air source, and the air nozzle can be connected to a visual recognition module. A waste trough is fixedly installed at the opening of the discharge platform near the discharge trough.

[0012] The discharge assembly includes a U-shaped plate, a sliding plate, and an arc-shaped baffle. The U-shaped plate is fixedly installed inside the discharge platform, and the sliding plate is slidably installed inside the U-shaped plate. The bottom end of the discharge chute extends into the interior of the discharge platform and is fixedly installed with a guide cylinder, which can fit together with the slide plate. An arc-shaped baffle is fixedly installed on the side of the slide away from the guide cylinder, and an opening is provided on the slide near the arc-shaped baffle, where a feed cylinder is fixedly installed.

[0013] The bottom end of the feeding cylinder is movably installed with an opening and closing door panel, and the bottom end of the discharge platform is fixedly installed with a weighing base. A slider is fixedly installed at the bottom of the opening and closing door panel, and a groove is provided on the weighing base corresponding to the slider of the opening and closing door panel.

[0014] A second threaded screw is rotatably installed on one side of the inside of the U-shaped plate, and a slide rod is fixedly installed on the other side of the inside of the U-shaped plate; One side of the slide plate is threadedly connected to the second threaded screw, and the other side of the slide plate slides together with the slide rod; A third motor is fixedly installed on one side of the outside of the U-shaped plate, and the output end of the third motor is fixedly connected to the second threaded screw.

[0015] A control method for a rotary tableting apparatus for esomeprazole production according to claim 1 includes the following steps: S1. Start the first motor. The first motor drives the pulley to rotate through the drive wheel and toothed belt, which in turn drives the rotary tableting mechanism to rotate. The mixed material enters the die hole of the rotary tableting mechanism through the feeding trough. S2. In the calculation chip, the controller controls the second motor to rotate forward or reverse. The second motor drives the first threaded screw to rotate, causing the fixed rod to rise and fall along the slide groove of the baffle, thereby adjusting the contact position between the guide wheel and the rotating pressing mechanism, so that the main pressure is kept within the set range. S3. The pressed tablets are output through the discharge chute. The visual recognition module collects images of the tablets passing below and identifies their appearance. If the tablets are deemed unqualified, the controller sends a trigger signal to the air nozzle. The air nozzle sprays air to blow the unqualified tablets into the waste chute through the opening of the discharge chute. S4. Qualified tablets enter the discharge assembly through the guide cylinder at the bottom of the discharge trough. At this time, the feeding cylinder on the slide plate is connected to the guide cylinder at the bottom of the discharge trough. The slider at the bottom of the opening and closing door plate slides into the weighing base to close the opening and closing door plate. The weighing base weighs the tablets trapped on the opening and closing door plate. When the weight reaches the set value, the controller starts the third motor. The third motor drives the second threaded screw to rotate, so that the slide plate, guided by the slide rod, moves the feeding cylinder away from the guide cylinder side of the discharge trough. At the same time, the opening and closing door plate separates from the weighing base, and the tablets fall naturally into the collection tank.

[0016] In step S4, the weighing base feeds the weighing result back to the controller. Based on the deviation between the weighing result and the theoretical weight, the controller controls the second motor to rotate forward or backward to adjust the position of the guide wheel and controls the speed of the first motor. When powder bridging occurs in the discharge hopper at the bottom of the feeding trough, the controller controls the pneumatic push rod to perform reciprocating linear motion. The pneumatic push rod drives the annular push plate to press down and move within the discharge hopper. When the collection trough is full or the discharge position needs to be changed, the controller starts the third motor to make the slide plate move horizontally, changing the discharge point of the feeding cylinder.

[0017] The present invention has at least the following beneficial effects: This device adjusts the tableting pressure in real time through a regulating structure, and can change the position of the guide rollers according to changes in material state, thus maintaining a stable tableting process. When tablet weight fluctuations or a tendency to crack occur, the pressure can be corrected promptly, reducing the production of defective tablets. This structure can operate without stopping the machine, which helps improve the stability of continuous production, reduces material waste, and meets the production requirements of esomeprazole enteric-coated tablets.

[0018] The present invention also has the following beneficial effects: The discharging platform integrates visual recognition and an air nozzle rejection structure, enabling automatic identification and separation of tablets with substandard appearance, reducing manual intervention. The arc-shaped baffle and feeding cylinder in the discharging assembly cushion the tablets, reducing the risk of drop damage. The weighing base allows for online weighing of sampled tablets, facilitating timely detection of abnormal tablet weights, thereby ensuring tableting quality and improving the overall practicality of the device.

[0019] The present invention also has the following beneficial effects: The bottom of the feeding cylinder is equipped with an opening and closing gate and a weighing base. During normal production, the tablets fall directly into the collection tank. When sampling inspection is required, the opening and closing gate closes for weighing. After weighing, a third motor drives the sliding plate to move laterally, moving the feeding cylinder away from the guide cylinder, and the tablets fall naturally. This structure achieves seamless connection between sampling inspection and feeding, avoids material spillage, facilitates switching collection channels, and improves the continuity of the production and packaging process. Attached Figure Description

[0020] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 This is a schematic diagram of the three-dimensional main view structure of the present invention; Figure 2 This is a schematic diagram of the three-dimensional rear view structure of the present invention; Figure 3 This is a schematic cross-sectional view of the overall structure of the present invention; Figure 4 This is a schematic diagram of the overall structure of the adjustment structure of the present invention; Figure 5 This is a schematic diagram of the overall structure of the discharge trough of the present invention; Figure 6 This is a front cross-sectional view of the material discharge platform of the present invention; Figure 7 This is a schematic cross-sectional view of the U-shaped plate structure of the present invention; Figure 8 This is a flowchart of the control method for the rotary tableting device used in the production of elastosteroids according to the present invention.

[0022] In the diagram: 1. Mounting base; 2. Baffle; 3. Rotary pressing mechanism; 4. Adjustment structure; 5. Feeding chute; 6. Discharge chute; 7. Discharge platform; 8. Vision recognition module; 9. Discharge assembly; 10. Belt pulley; 11. First motor; 12. Guide wheel; 13. Fixing rod; 14. First threaded screw; 15. Second motor; 16. Mounting platform; 17. Pneumatic push rod; 18. Air nozzle; 19. Waste chute; 20. U-shaped plate; 21. Slide plate; 22. Arc-shaped baffle; 23. Feeding cylinder; 24. Opening and closing door panel; 25. Weighing base; 26. Third motor; 27. Second threaded screw; 28. Slide rod. Detailed Implementation

[0023] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0024] Example 1: Rotary tableting device for esomeprazole production Reference Figure 1-7 This embodiment provides a rotary tableting device for esomeprazole production, including a mounting base 1. A controller is installed on one side of the front of the mounting base 1. A set of baffles 2 are fixedly installed on both sides of the top of the mounting base 1. A rotary tableting mechanism 3 is rotatably installed in the middle of the interior of the mounting base 1. A temperature and humidity sensor is installed on the side of the mounting base 1 near the rotary tableting mechanism 3, and the temperature and humidity sensor is electrically connected to the controller. An adjustment structure 4 is provided between the tops of the two sets of baffles 2, and the bottom surface of the adjustment structure 4 can fit against the rotary tableting mechanism 3. A discharge platform 7 is fixedly installed on one side of the mounting base 1. A discharge trough 6 is fixedly installed on one side of the top of the discharge platform 7, and the other end of the discharge trough 6 fits against the rotary tableting mechanism 3. A discharge assembly 9 is provided inside the discharge platform 7, and a collection trough is provided on the side of the discharge platform 7 near the discharge assembly 9.

[0025] A first motor 11 is fixedly mounted on one side inside the mounting base 1, and a drive wheel is fixedly mounted on the output end of the first motor 11. A pulley 10 is fixedly mounted on the bottom end of the rotary tablet pressing mechanism 3, and the pulley 10 and the drive wheel are connected by a toothed belt. After the first motor 11 is powered on and started, its output end drives the drive wheel to rotate, which in turn drives the pulley 10 to rotate synchronously through the toothed belt, thereby driving the rotary tablet pressing mechanism 3 to perform rotary tablet pressing. The meshing transmission of the toothed belt effectively prevents transmission slippage under high-speed operation, ensuring stable tablet pressing speed and uniform torque output of the equipment. The first motor 11 adopts a three-phase asynchronous frequency conversion motor or an AC servo motor to meet the working requirements of high torque and stepless smooth speed regulation.

[0026] The adjusting structure 4 includes a guide wheel 12 and a fixing rod 13. A set of sliding grooves is fixedly installed on each side of the two sets of baffles 2, and a fixing rod 13 is slidably installed between the two sets of sliding grooves. The guide wheel 12 is fixedly installed on one side of the fixing rod 13. The fixing rod 13 slides within the sliding grooves of the two sets of baffles 2, providing stable lateral support for the guide wheel 12 and limiting its offset during use. The bottom of the guide wheel 12 is in contact with the top of the mold of the rotary pressing mechanism 3, providing stable downward guiding force through rolling contact, ensuring the transmission of main pressure while reducing mechanical wear. A first threaded screw 14 is threaded onto one side of the fixing rod 13, and the first threaded screw 14 is rotatably installed inside the sliding groove of the baffle 2. A second motor 15 is fixedly installed on the side of the baffle 2 near the first threaded screw 14, and the output end of the second motor 15 is fixedly installed together with the first threaded screw 14. When adjusting the machine before formal tableting or when adjusting tablet thickness and weight during production, the system controls the second motor 15 to rotate forward or backward, driving the first threaded screw 14 to rotate. This threaded transmission drives the fixed rod 13 to rise and fall along the slide groove, thereby changing the pressure position of the guide wheel 12 on the rotating tableting mechanism 3. The second motor 15 is a high-precision stepper motor or servo motor with a built-in position feedback encoder; the first threaded screw 14 can be a high-precision ball screw to reduce backlash.

[0027] A mounting platform 16 is fixedly mounted on the side of the mounting base 1 near the rotary tableting mechanism 3. A feeding trough 5 is fixedly mounted on the top of the mounting platform 16, and a discharge funnel is provided at the bottom of the feeding trough 5. A pneumatic push rod 17 is fixedly mounted on one side of the mounting platform 16, and an annular push plate is fixedly mounted on the other end of the pneumatic push rod 17. One side of the pneumatic push rod 17 is connected to an external air source. The mixed material falls into the discharge funnel through the feeding trough 5. To prevent powder bridging at the throat of the funnel, the pneumatic push rod 17 is controlled to perform reciprocating linear motion, driving the annular push plate to press and move inside the funnel, achieving forced homogeneous feeding and ensuring the uniformity and continuity of material filling in the die hole. The pneumatic push rod 17 is a double-acting cylinder, and its extension and retraction are controlled by a two-position five-way high-frequency solenoid valve.

[0028] A vision recognition module 8 is fixedly installed on the side of the discharge platform 7 near the discharge trough 6, with the bottom surface of the vision recognition module 8 facing the side of the discharge trough 6. An opening is provided on one side of the discharge trough 6, and an air nozzle 18 is fixedly installed on the side of the discharge trough 6 away from the opening. The other end of the air nozzle 18 is connected to an external air source, and the air nozzle 18 can be connected to the vision recognition module 8. A waste trough 19 is fixedly installed on the discharge platform 7 near the opening of the discharge trough 6. After the tablets enter the discharge trough 6 from the rotary tableting mechanism 3, they pass directly below the vision recognition module 8. The vision recognition module 8 performs high-speed image acquisition of the tablets and extracts feature parameters to identify whether there are any defects such as cracked tablets, uneven tablet surfaces, or sticking. Once a defect is determined, the system sends a millisecond-level trigger signal to the air nozzle 18, spraying a high-pressure airflow to blow the waste tablets from the opening into the waste trough 19, thus automating the waste removal process. The visual recognition module 8 uses an industrial CCD camera or CMOS camera, paired with a machine vision controller; the air nozzle 18 is controlled by a high-speed response solenoid valve to control the on / off of clean compressed air.

[0029] The discharging assembly 9 includes a U-shaped plate 20, a sliding plate 21, and an arc-shaped baffle 22. The U-shaped plate 20 is fixedly installed inside the discharging platform 7, and the sliding plate 21 is slidably installed inside the U-shaped plate 20. The bottom end of the discharging trough 6 extends into the discharging platform 7 and is fixedly installed with a guide cylinder, which fits snugly against the sliding plate 21. An arc-shaped baffle 22 is fixedly installed on the side of the sliding plate 21 away from the guide cylinder, and an opening is provided near the arc-shaped baffle 22 on the sliding plate 21, where a feeding cylinder 23 is fixedly installed. Qualified tablets fall along the guide cylinder at the bottom of the discharging trough 6. The sliding plate 21 and the arc-shaped baffle 22 provide smooth arc-shaped guidance and cushioning for the falling tablets, allowing them to decelerate and finally fall into the feeding cylinder 23 through the opening. This cushioning structure prevents the tablets from breaking, cracking, or shattering due to rigid impact during fall, ensuring the tablets meet the acceptable brittleness requirements.

[0030] A hinged door 24 is movably mounted at the bottom of the feeding cylinder 23, and a weighing base 25 is fixedly mounted at the bottom of the discharge platform 7. A slider is fixedly mounted at the bottom of the hinged door 24, and a groove is provided on the weighing base 25 corresponding to the slider of the hinged door 24. To achieve online process monitoring, the hinged door 24 at the bottom of the feeding cylinder 23 is open under normal conditions, and the tablets flow directly into the collection tank; when quality sampling is required, the hinged door 24 closes, and the intercepted tablets fall onto the door and are transmitted to the weighing base 25 for dynamic weighing. After weighing, the slider at the bottom of the hinged door 24 moves horizontally along the groove to open, releasing the sampled tablets, forming a seamless connection between sampling and feeding. The weighing base 25 integrates a high-precision miniature resistance strain gauge weighing sensor module; the opening and closing drive of the hinged door 24 can be a miniature cylinder or a miniature electric push rod.

[0031] A second threaded screw 27 is rotatably mounted on one side of the U-shaped plate 20, and a slide rod 28 is fixedly mounted on the other side of the U-shaped plate 20. One side of the slide plate 21 is threadedly connected to the second threaded screw 27, and the other side of the slide plate 21 slides against the slide rod 28. A third motor 26 is fixedly mounted on one side of the U-shaped plate 20, and the output end of the third motor 26 is fixedly connected to the second threaded screw 27. When the full-load collection trough below the discharge platform needs to be replaced, or when tablets for a specific time period need to be distributed to other channels, the system starts the third motor 26, driving the second threaded screw 27 to rotate; the slide plate 21 moves horizontally along the screw under the guidance and limit of the slide rod 28, thereby changing the discharge point position of the discharge cylinder 23. This structure ensures a smooth and stable material receiving and switching process, avoids material spillage, and improves the continuity of the production and packaging process. The third motor 26 is a stepper motor or a servo motor, with position self-locking and positioning functions.

[0032] Example 2: Rotary tableting device for esomeprazole production based on closed-loop feedback regulation The difference between this embodiment and embodiment 1 is that the adjustment structure 4 uses a pressure sensor and the second motor 15 to form a closed-loop control, and the parameters are optimized for the specifications of the ipramazole enteric-coated tablets.

[0033] In this embodiment, a pressure sensor is installed between the guide wheel 12 and the mold of the rotary tableting mechanism 3, and the pressure sensor is connected to the controller. The controller pre-stores the correspondence between the content of the esomeprazole intermediate and the theoretical tablet weight, and sets the main pressure target range. During the tableting process, the pressure sensor detects the actual pressure applied by the guide wheel 12 in real time and feeds the signal back to the controller. The controller compares the actual pressure with the target range. If the actual pressure is lower than the lower limit of the target, it is determined that the tablet is not compacted, and the second motor 15 is controlled to rotate forward, so that the fixed rod 13 moves down along the slide groove, and the downward pressure of the guide wheel 12 increases. If the actual pressure is higher than the upper limit of the target, it is determined that the tablet is over-pressurized and there is a risk of crushing. The second motor 15 is controlled to rotate in reverse, so that the fixed rod 13 moves up, and the downward pressure of the guide wheel 12 decreases.

[0034] Meanwhile, the visual recognition module 8 detects the appearance of the tablets at the discharge trough 6. If cracked or stuck tablets are found, the controller combines the pressure sensor data to determine whether it is due to abnormal pressure. If the pressure is normal but cracked tablets are still present, the controller adjusts the operating frequency of the pneumatic push rod 17 or the discharge speed of the discharge trough 5 to improve the uniformity of material filling. The weighing base 25 weighs the sampled tablets. If the total weight exceeds the theoretical tablet weight range, the controller prioritizes adjusting the second motor 15 to change the position of the guide wheel 12, and can simultaneously adjust the speed of the first motor 11 to keep the tableting speed stable.

[0035] In this embodiment, the second motor 15 is a servo motor, and the first threaded screw 14 is a high-precision ball screw with small backlash and high positional accuracy. The controller also sets the target range for hardness, the upper limit for friability, and the upper limit for disintegration time. When the hardness of the sampled tablets is below the lower limit, the controller controls the second motor 15 to rotate forward, increasing the compression; when the hardness is above the upper limit, the controller controls the second motor 15 to rotate in reverse, decreasing the compression. By combining pressure closed-loop control with visual and weighing feedback, automatic fine-tuning of the esomeprazole enteric-coated tablet compression process is achieved, correcting deviations without stopping the machine.

[0036] A vision recognition module 8 is fixedly installed on the side of the discharge platform 7 near the discharge trough 6. An opening is provided on one side of the discharge trough 6, and an air nozzle 18 is fixedly installed on the side of the discharge trough 6 away from the opening. The air nozzle 18 is connected to the vision recognition module 8. A waste trough 19 is fixedly installed on the discharge platform 7 near the opening of the discharge trough 6. When the vision recognition module 8 detects a defective tablet, the system sends a trigger signal to the air nozzle 18, blowing the defective tablet into the waste trough 19. The discharge assembly 9 includes a U-shaped plate 20, a sliding plate 21, and an arc-shaped baffle 22. Qualified tablets enter the buffer channel between the sliding plate 21 and the arc-shaped baffle 22 via a guide cylinder, and then enter the discharge cylinder 23. The opening and closing door plate 24 at the bottom of the discharge cylinder 23 cooperates with the weighing base 25 to form an online sampling inspection station. During normal production, the opening and closing door 24 is open, and the tablets fall directly into the collection tank; when the system needs to perform a uniformity test of the central control dosage unit, the opening and closing door 24 is closed, and the tablets fall onto the door, and the weighing base 25 performs dynamic weighing.

[0037] Example 3: Rotary tableting device for esomeprazole production integrating discharge weighing and sorting The difference between this embodiment and embodiment 1 is that the discharge component 9 adopts a multi-channel sorting structure and integrates visual recognition, air nozzle rejection, weighing and sampling inspection and the transverse sorting of the discharge cylinder 23 into an integrated control process.

[0038] In this embodiment, an air nozzle 18 is provided at the opening on one side of the discharge trough 6. The air nozzle 18 is controlled by a high-speed response solenoid valve to control the flow of clean compressed air. When the visual recognition module 8 detects a defective tablet, the system sends a trigger signal to the air nozzle 18 to blow the defective tablet into the waste trough 19. Qualified tablets fall along the guide tube at the bottom of the discharge trough 6 into the buffer channel between the slide plate 21 and the arc-shaped baffle 22, and then enter the feed cylinder 23.

[0039] The opening / closing gate 24 at the bottom of the feeding cylinder 23 cooperates with the weighing base 25 to form an online sampling inspection station. During normal production, the opening / closing gate 24 is open, and the tablets fall directly into the collection tank. When the system needs to perform a dose uniformity test, the opening / closing gate 24 closes, trapping the tablets on the gate, and the weighing base 25 performs dynamic weighing. The weighing data is transmitted to the controller, which calculates the relative standard deviation of all samples and determines whether the average value of each sampling point and all units are within the target dose range. If the weighing results meet the requirements, the opening / closing gate 24 opens, and the tablets are released; if not, the controller records the abnormality and triggers an alarm.

[0040] A second threaded screw 27 is rotatably mounted on one side of the U-shaped plate 20, and a slide bar 28 is fixedly mounted on the other side. One side of the slide plate 21 is threaded onto the second threaded screw 27, and the other side is slidably engaged with the slide bar 28. A third motor 26 is fixedly mounted on the outer side of the U-shaped plate 20, and the output end of the third motor 26 is fixedly connected to the second threaded screw 27. When the collection tank is full and needs to be replaced, or when tablets need to be distributed to other channels for a specific time period, the system starts the third motor 26, driving the second threaded screw 27 to rotate. The slide plate 21 moves horizontally under the guidance of the slide bar 28, changing the discharge point position of the feed cylinder 23. In this embodiment, the third motor 26 is a stepper motor or a servo motor, with position self-locking and positioning functions, ensuring a smooth and stable material collection and switching process and preventing material spillage.

[0041] In this embodiment, a pneumatic pusher 17 and an annular pusher plate are installed at the discharge funnel at the bottom of the feeding trough 5. The pneumatic pusher 17 is a double-acting cylinder, which works in conjunction with a two-position five-way high-frequency solenoid valve to control the extension and retraction action, preventing powder bridging. The visual recognition module 8 uses an industrial CCD camera or CMOS camera, combined with an LED light source and image processing algorithms. The weighing base 25 integrates a high-precision miniature resistance strain gauge weighing sensor module. With the above structure, the device can simultaneously achieve appearance rejection, online weighing, dosage unit uniformity assessment, and material sorting during the tableting process of esomeprazole enteric-coated tablets, meeting the quality requirements of esomeprazole enteric-coated tablets.

[0042] Example 4: Rotary tableting device for esomeprazole production with temperature and humidity monitoring function This embodiment provides a rotary tableting device for the production of esomeprazole, including a mounting base 1. A controller is installed on one side of the front of the mounting base 1. A set of baffles 2 are fixedly installed on both sides of the top of the mounting base 1. A rotary tableting mechanism 3 is rotatably installed in the middle of the interior of the mounting base 1. A temperature and humidity sensor is installed on the side of the mounting base 1 near the rotary tableting mechanism 3, and the temperature and humidity sensor is electrically connected to the controller. An adjustment structure 4 is provided between the tops of the two sets of baffles 2, and the bottom surface of the adjustment structure 4 can fit against the rotary tableting mechanism 3. A discharge platform 7 is fixedly installed on one side of the mounting base 1. A discharge trough 6 is fixedly installed on one side of the top of the discharge platform 7, and the other end of the discharge trough 6 fits against the rotary tableting mechanism 3. A discharge assembly 9 is provided inside the discharge platform 7, and a collection trough is provided on the side of the discharge platform 7 near the discharge assembly 9.

[0043] Esomeprazole is a benzimidazole proton pump inhibitor, sensitive to moisture and heat. Its sulfinyl group structure is prone to hydrolysis, oxidation, and polymerization upon contact with water and high temperatures. During the tableting stage, the powder is exposed to air, resulting in a large surface area exposed to air. When the temperature and humidity exceed the specified range, it can negatively impact product quality. Therefore, in this embodiment, the controller presets the temperature range inside the tablet press to 18–24°C and the relative humidity range to 40%–55%. Temperature and humidity sensors monitor the temperature and relative humidity inside the tablet press in real time and transmit the detection signals to the controller. When the temperature or relative humidity exceeds the above range, the controller activates the air conditioner and / or dehumidifier to regulate the temperature and humidity inside the tablet press, maintaining the tableting environment within the set range. This reduces the risk of hydrolysis, oxidation, and polymerization of the esomeprazole powder, ensuring stable tablet quality.

[0044] A first motor 11 is fixedly installed on one side inside the mounting base 1, and a drive wheel is fixedly installed on the output end of the first motor 11. A pulley 10 is fixedly installed on the bottom end of the rotary pressing mechanism 3, and the pulley 10 and the drive wheel are connected together by a toothed belt. After the first motor 11 is powered on and started, it drives the pulley 10 to rotate synchronously through the toothed belt, thereby driving the rotary pressing mechanism 3 to perform rotary pressing. The adjusting structure 4 includes a guide wheel 12 and a fixed rod 13. A set of sliding grooves is fixedly installed on both sides of the two sets of baffles 2, and a set of fixed rods 13 is slidably installed between the two sets of sliding grooves. A guide wheel 12 is fixedly installed on one side of the fixed rod 13. A first threaded screw 14 is threadedly installed on one side of the fixed rod 13, and the first threaded screw 14 is rotatably installed inside the sliding groove of the baffle 2. A second motor 15 is fixedly installed on the side of the baffle 2 near the first threaded screw 14, and the output end of the second motor 15 is fixedly installed together with the first threaded screw 14. The system controls the second motor 15 to rotate forward or backward, driving the first threaded screw 14 to rotate, which in turn drives the fixed rod 13 to rise and fall along the slide groove, thereby changing the pressure position of the guide wheel 12 on the rotating tableting mechanism 3 and adjusting the tableting pressure.

[0045] A mounting platform 16 is fixedly installed on the side of the mounting base 1 near the rotary tableting mechanism 3. A feeding trough 5 is fixedly installed on the top of the mounting platform 16, and a discharge funnel is provided at the bottom of the feeding trough 5. A pneumatic push rod 17 is fixedly installed on one side of the mounting platform 16, and an annular push plate is fixedly installed on the other end of the pneumatic push rod 17. The mixed material falls into the discharge funnel through the feeding trough 5. The pneumatic push rod 17 is controlled to perform reciprocating linear motion, driving the annular push plate to press and move inside the funnel to prevent powder bridging. A vision recognition module 8 is fixedly installed on the side of the discharge platform 7 near the discharge trough 6. An opening is provided on one side of the discharge trough 6, and an air nozzle 18 is fixedly installed on the side of the discharge trough 6 away from the opening. The air nozzle 18 is connected to the vision recognition module 8. A waste trough 19 is fixedly installed on the discharge platform 7 near the opening of the discharge trough 6. The tablets are output through the discharge trough 6. After the visual recognition module 8 identifies the unqualified appearance, the controller triggers the air nozzle 18 to blow the waste tablets into the waste trough 19.

[0046] The discharge assembly 9 includes a U-shaped plate 20, a sliding plate 21, and an arc-shaped baffle 22. The U-shaped plate 20 is fixedly installed inside the discharge platform 7, and the sliding plate 21 is slidably installed inside the U-shaped plate 20. The bottom end of the discharge chute 6 extends into the discharge platform 7 and is fixedly installed with a guide cylinder, which can fit against the sliding plate 21. An arc-shaped baffle 22 is fixedly installed on the side of the sliding plate 21 away from the guide cylinder. An opening is provided on the sliding plate 21 near the arc-shaped baffle 22, and a discharge cylinder 23 is fixedly installed thereon. An opening / closing door plate 24 is movably installed at the bottom end of the discharge cylinder 23, and a weighing base 25 is fixedly installed at the bottom end of the discharge platform 7. A slider is fixedly installed at the bottom end of the opening / closing door plate 24, and a groove is provided on the weighing base 25 corresponding to the slider of the opening / closing door plate 24. Qualified tablets enter the discharge cylinder 23 through the guide cylinder. When sampling inspection is required, the opening / closing door plate 24 closes, and the weighing base 25 performs weighing. A second threaded screw 27 is rotatably mounted on one side of the U-shaped plate 20, and a slide rod 28 is fixedly mounted on the other side. One side of the slide plate 21 is threadedly connected to the second threaded screw 27, and the other side slides against the slide rod 28. A third motor 26 is fixedly mounted on one side of the U-shaped plate 20, and the output end of the third motor 26 is fixedly connected to the second threaded screw 27. When the collection tank is full or the material discharge position needs to be changed, the controller starts the third motor 26, driving the slide plate 21 to move horizontally, changing the discharge point of the discharge cylinder 23.

[0047] This embodiment uses temperature and humidity sensors linked to a controller, air conditioner, and dehumidifier to maintain the temperature inside the tablet press at 18–24°C and the relative humidity at 40%–55%. This effectively prevents the esomeprazole powder from hydrolyzing, oxidizing, or polymerizing due to excessive temperature and humidity, further ensuring the stability of the tableting process and product quality. The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed invention. The scope of protection claimed by the appended claims and their equivalents is defined.

Claims

1. A rotary tableting device for producing esomeprazole, comprising a mounting base (1), a controller being provided on one side of the front of the mounting base (1), a set of baffles (2) being fixedly installed on both sides of the top of the mounting base (1), a rotary tableting mechanism (3) being rotatably installed in the middle of the interior of the mounting base (1), a temperature and humidity sensor being provided on the side of the mounting base (1) near the rotary tableting mechanism (3), and the temperature and humidity sensor being electrically connected to the controller, further comprising: An adjustment structure (4) is provided between the top ends of the two sets of baffles (2), and the bottom surface of the adjustment structure (4) can fit together with the rotating tablet pressing mechanism (3); A discharge platform (7) is fixedly installed on one side of the mounting base (1), and a discharge trough (6) is fixedly installed on one side of the top of the discharge platform (7), and the other end of the discharge trough (6) is attached to the rotary tablet pressing mechanism (3). A discharge component (9) is provided inside the discharge platform (7), and a collection trough is provided on the side of the discharge platform (7) near the discharge component (9).

2. The rotary tableting device for esomeprazole production according to claim 1, characterized in that, A first motor (11) is fixedly installed on one side inside the mounting base (1), and a drive wheel is fixedly installed at the output end of the first motor (11). The bottom end of the rotary pressing mechanism (3) is fixedly installed with a belt pulley (10), and the belt pulley (10) and the drive wheel are connected together by a toothed belt.

3. The rotary tableting apparatus for esomeprazole production according to claim 1, characterized in that, The adjustment structure (4) includes a guide wheel (12) and a fixed rod (13). A set of sliding grooves are fixedly installed on both sides of the two sets of baffles (2), and a set of fixed rods (13) is slidably installed between the two sets of sliding grooves. A guide wheel (12) is fixedly installed on one side of the fixed rod (13). The first threaded screw (14) is threaded on one side of the fixed rod (13), and the first threaded screw (14) is rotatably installed inside the groove of the baffle (2); The baffle (2) is fixedly installed with a second motor (15) on the side near the first threaded screw (14), and the output end of the second motor (15) is fixedly installed together with the first threaded screw (14).

4. The rotary tableting apparatus for esomeprazole production according to claim 1, characterized in that, The mounting base (1) is fixedly mounted with a mounting platform (16) on one side near the rotating tablet pressing mechanism (3), and a feeding trough (5) is fixedly mounted on the top of the mounting platform (16), and a discharge funnel is provided at the bottom of the feeding trough (5). A pneumatic push rod (17) is fixedly installed on one side of the mounting platform (16), and an annular push plate is fixedly installed on the other end of the pneumatic push rod (17). One side of the pneumatic push rod (17) is connected to an external air source.

5. The rotary tableting apparatus for producing elastosteroids according to claim 1, characterized in that, The discharge platform (7) is fixedly installed with a visual recognition module (8) on the side close to the discharge trough (6), and the bottom surface of the visual recognition module (8) faces the side of the discharge trough (6). The discharge trough (6) has an opening on one side, and an air nozzle (18) is fixedly installed on the side of the discharge trough (6) away from the opening. The other end of the air nozzle (18) is connected to an external air source. The air nozzle (18) can be connected to the visual recognition module (8). The discharge platform (7) is fixedly installed with a waste trough (19) near the opening of the discharge trough (6).

6. A rotary tableting apparatus for the production of elastosteroids according to claim 5, characterized in that, The discharge assembly (9) includes a U-shaped plate (20), a sliding plate (21) and an arc-shaped baffle (22). The U-shaped plate (20) is fixedly installed inside the discharge platform (7), and the sliding plate (21) is slidably installed inside the U-shaped plate (20). The bottom end of the discharge trough (6) extends into the interior of the discharge platform (7) and is fixedly installed with a guide cylinder, which can fit together with the slide plate (21); An arc-shaped baffle (22) is fixedly installed on the side of the slide plate (21) away from the guide cylinder, and an opening is provided on the slide plate (21) near the arc-shaped baffle (22) and a feed cylinder (23) is fixedly installed thereon.

7. A rotary tableting apparatus for the production of elastosteroids according to claim 6, characterized in that, The bottom end of the feeding cylinder (23) is movably installed with an opening and closing door plate (24), and the bottom end of the discharge platform (7) is fixedly installed with a weighing base (25). The bottom end of the opening and closing door panel (24) is fixedly installed with a slider, and the weighing base (25) is provided with a groove corresponding to the slider of the opening and closing door panel (24).

8. A rotary tableting apparatus for the production of elastosteroids according to claim 7, characterized in that, A second threaded screw (27) is rotatably installed on one side of the interior of the U-shaped plate (20), and a slide rod (28) is fixedly installed on the other side of the interior of the U-shaped plate (20). One side of the slide plate (21) is threaded together with the second threaded screw (27), and the other side of the slide plate (21) slides together with the slide rod (28); A third motor (26) is fixedly installed on one side of the outside of the U-shaped plate (20), and the output end of the third motor (26) is fixedly connected to the second threaded screw (27).

9. A control method for a rotary tableting apparatus for esomeprazole production according to claim 1, characterized in that, Includes the following steps: S1. Start the first motor (11). The first motor (11) drives the belt pulley (10) to rotate through the drive wheel and toothed belt, thereby driving the rotary tableting mechanism (3) to rotate. The mixed material enters the die hole of the rotary tableting mechanism (3) through the feeding trough (5). S2. In the calculation chip, the controller controls the second motor (15) to rotate forward or reverse. The second motor (15) drives the first threaded screw (14) to rotate, so that the fixed rod (13) moves up and down along the slide groove of the baffle (2), thereby adjusting the contact position between the guide wheel (12) and the rotating pressing mechanism (3) so that the main pressure is kept within the set range. S3. The pressed tablets are output through the discharge trough (6). The visual recognition module (8) collects images of the tablets passing below it and identifies their appearance. If the tablets are deemed unqualified, the controller sends a trigger signal to the air nozzle (18). The air nozzle (18) sprays air to blow the unqualified tablets into the waste trough (19) through the opening of the discharge trough (6). S4. Qualified tablets enter the discharge assembly (9) through the guide tube at the bottom of the discharge trough (6). At this time, the feeding tube (23) on the slide plate (21) is connected to the guide tube at the bottom of the discharge trough (6). The slider at the bottom of the opening and closing door plate (24) slides into the weighing base (25) to close the opening and closing door plate (24). The weighing base (25) weighs the tablets trapped on the opening and closing door plate (24). When the weight reaches the set value, the controller starts the third motor (26). The third motor (26) drives the second threaded screw (27) to rotate, so that the slide plate (21) is guided by the slide rod (28) to drive the feeding tube (23) away from the guide tube side of the discharge trough (6). At the same time, the opening and closing door plate (24) separates from the weighing base (25), and the tablets fall naturally into the collection tank.

10. The control method for a rotary tableting device for esomeprazole production according to claim 9, characterized in that, In step S4, the weighing base (25) feeds back the weighing result to the controller. The controller controls the second motor (15) to rotate forward or backward to adjust the position of the guide wheel (12) and control the speed of the first motor (11) according to the deviation between the weighing result and the theoretical weight. When powder bridging occurs in the discharge hopper at the bottom of the trough (5), the controller controls the pneumatic push rod (17) to perform reciprocating linear motion. The pneumatic push rod (17) drives the ring push plate to press down and move in the discharge hopper. When the collection tank is full or the discharge position needs to be changed, the controller starts the third motor (26) to make the slide plate (21) move horizontally and change the discharge point of the discharge cylinder (23).

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