Method for preparing a contact lens storage solution

Abstract

A method for preparing a contact lens preservation solution includes mixing and homogenizing an amphiphilic copolymer (A) having the structure of formula (I), an amphiphilic copolymer (B) having the structure of formula (II), and water to obtain a first mixture containing micelles; adding a lipophilic component containing lutein and zeaxanthin and homogenizing to obtain a second mixture containing a micelle complex; adding a moisturizing component and homogenizing to obtain a third mixture; adjusting the osmotic pressure and pH value of the third mixture to obtain a fourth mixture; and homogenizing and filtering the fourth mixture to obtain the contact lens preservation solution. In formula (I), x is 100, y ranges from 10 to 400, and z ranges from 2 to 50; in formula (II), the sum of p and q is 100, p is 80, and q is 20. The preparation method of the present invention allows lutein and zeaxanthin to dissolve in the contact lens preservation solution for a long time without precipitation, and enables contact lenses stored in the contact lens preservation solution to have anti-blue light effects.

Description

Technical Field

[0001] This invention relates to a solution for contact lenses, and more particularly to a method for preparing a preservation solution for contact lenses. Background Technology

[0002] Lutein and zeaxanthin are important lipophilic vitamins that can prevent macular degeneration in the eye, and are generally obtained from daily diet or health supplements. However, it takes a long time for lutein and zeaxanthin to be absorbed through the gastrointestinal tract and reach the macula via blood circulation. Therefore, allowing the eyes to absorb lutein and zeaxanthin directly would significantly shorten this time. Since modern people often choose to wear contact lenses for aesthetics and convenience, allowing the eyes to absorb lutein and zeaxanthin simultaneously while wearing contact lenses would be a win-win situation.

[0003] However, contact lenses are stored in contact lens preservation solutions when not in use. Since the main component of these solutions is water, adding lipophilic substances like lutein and zeaxanthin directly to the solution will inevitably cause precipitation, preventing them from adhering to the contact lenses and being absorbed by the eyes. On the other hand, while amphiphilic substances can be added during the preparation of the preservation solution to aid in the dissolution of lutein and zeaxanthin, their effect is limited. Even after a week of storage, precipitation will still occur in the preservation solution.

[0004] Based on the above, the goal that still needs to be achieved is to prepare a preservation solution for contact lenses containing dissolved lutein and zeaxanthin, and to ensure that lutein and zeaxanthin do not precipitate out in the preservation solution for a long time. Summary of the Invention

[0005] The purpose of this invention is to provide a method for preparing a contact lens preservation solution that allows lutein and zeaxanthin to dissolve in the solution for a long time without precipitation.

[0006] The present invention provides a method for preparing a preservation solution for contact lenses, comprising the following steps: step (a), step (b), step (c), step (d), and step (e).

[0007] Step (a) involves mixing and homogenizing the amphiphilic copolymer (A), the amphiphilic copolymer (B), and water to form micelles together, thereby obtaining a first mixture containing the micelles.

[0008] In step (b), a lipophilic component containing lutein and zeaxanthin is added to the first mixture and homogenized to encapsulate the lipophilic component in the micelles, forming a micelle complex containing lutein and zeaxanthin, thereby obtaining a second mixture containing the micelle complex.

[0009] Step (c) involves adding a functional component containing moisturizing ingredients to the second mixture and homogenizing it to completely dissolve the functional component and the micelle complex, thereby obtaining a third mixture.

[0010] Step (d) involves adjusting the osmotic pressure and pH value of the third mixture to obtain the fourth mixture.

[0011] Step (e) involves homogenizing and filtering the fourth mixture to obtain a preservation solution for contact lenses.

[0012] The amphiphilic copolymer (A) has a structure as shown in formula (I).

[0013]

[0014] In the above formula (I), x is 100, y ranges from 10 to 400, and z ranges from 2 to 50.

[0015] The amphiphilic copolymer (B) has a structure as shown in formula (II).

[0016]

[0017] In the above formula (II), with the sum of p and q being 100, p is 80 and q is 20.

[0018] In the preparation method of the contact lens preservation solution of the present invention, the lipophilic component further comprises meso-zeaxanthin.

[0019] In the preparation method of the contact lens preservation solution of the present invention, the ratio of lutein to zeaxanthin is 5:1.

[0020] In the method for preparing the preservation solution for contact lenses according to the present invention, the moisturizing component is selected from at least one of hyaluronic acid, tamarind gum, polyacrylic acid, carboxymethyl cellulose, dextran, hydroxypropyl methyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polysorbate 80, and alginate.

[0021] In the method for preparing the preservation solution for contact lenses according to the present invention, the functional components further include vitamin components.

[0022] In the method for preparing the preservation solution for contact lenses according to the present invention, the vitamin component is selected from at least one of vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, nicotinic acid, and folic acid.

[0023] In the method for preparing the preservation solution for contact lenses according to the present invention, the functional components further include pharmaceutical components.

[0024] In the preparation method of the contact lens preservation solution of the present invention, the pharmaceutical component is selected from at least one of menthol, tyrosine, taurine, potassium L-aspartate, neostigmine methyl sulfate, chlorpheniramine maleate, sodium flavin adenine dinucleotide, ε-aminohexanoic acid, dipotassium glycyrrhizate, zinc sulfate hydrate, berberine hydrochloride hydrate, tetrahydrozoline, naphazoline, sodium chondroitin sulfate, potassium chloride, and sodium chloride.

[0025] In the method for preparing a preservation solution for contact lenses according to the present invention, step (d) involves adjusting the osmotic pressure of the third mixture with at least one of sodium chloride and potassium chloride.

[0026] In the method for preparing a preservation solution for contact lenses according to the present invention, step (d) adjusts the pH value of the third mixture by at least one of borate, phosphate and carbonate.

[0027] The beneficial effects of this invention are as follows: by using the amphiphilic copolymer (A) and the amphiphilic copolymer (B) to jointly form micelles, and by encapsulating the lipophilic components containing lutein and zeaxanthin within the micelles, the contact lens preservation solution prepared by the method described above allows the lipophilic components containing lutein and zeaxanthin to dissolve within it, and no precipitation occurs even after prolonged storage. Furthermore, since the lutein and zeaxanthin in the micelle complex also have the effect of absorbing blue light, contact lenses stored in the contact lens preservation solution with the micelle complex distributed on the lens surface possess anti-blue light properties. Detailed Implementation

[0028] The present invention provides a method for preparing a preservation solution for contact lenses, comprising the following steps: step (a), step (b), step (c), step (d) and step (e).

[0029] Step (a) involves mixing an amphiphilic copolymer (A), an amphiphilic copolymer (B), and water, and then homogenizing them to form micelles from the amphiphilic copolymer (A) and the amphiphilic copolymer (B), thereby obtaining a first mixture containing the micelles.

[0030] The amphiphilic copolymer (A) has a structure as shown in formula (I).

[0031]

[0032] In the above formula (I), x is 100, y ranges from 10 to 400, and z ranges from 2 to 50.

[0033] The amphiphilic copolymer (B) has a structure as shown in formula (II).

[0034]

[0035] In the above formula (II), with the sum of p and q being 100, p is 80 and q is 20.

[0036] In step (b), a lipophilic component containing lutein and zeaxanthin is added to the first mixture and homogenized to encapsulate the lipophilic component in the micelles to form a micelle complex containing lutein and zeaxanthin, thereby obtaining a second mixture containing the micelle complex.

[0037] Step (c) involves adding a functional component containing a moisturizing element to the second mixture and homogenizing it to completely dissolve the functional component and the micelle complex, thereby obtaining a third mixture.

[0038] Step (d) involves adjusting the osmotic pressure and pH value of the third mixture to obtain a fourth mixture.

[0039] Step (e) involves homogenizing and filtering the fourth mixture to obtain a preservation solution for contact lenses.

[0040] In step (a), the amphiphilic copolymer (A) and the amphiphilic copolymer (B) can co-form micelles that are soluble in water and have an oleophilic portion. That is, the micelles can be dispersed in water, and the first mixture is a homogeneous liquid, which facilitates subsequent treatment of lutein and zeaxanthin with the micelles. Furthermore, using the amphiphilic copolymer (B) also helps to provide good moisturizing properties for the eyes in contact lenses.

[0041] In some embodiments of the present invention, the weight-average molecular weight of the amphiphilic copolymer (A) ranges from 50,000 to 1,000,000. In some embodiments of the present invention, the amount of amphiphilic copolymer (A) is 0.01 wt% to 1.0 wt%, based on a total of 100 wt% of the total amount of the amphiphilic copolymer (A), the amphiphilic copolymer (B), and the water. In a specific example of the present invention, the amount of amphiphilic copolymer (A) is 0.10 wt%, based on a total of 100 wt% of the total amount of the amphiphilic copolymer (A), the amphiphilic copolymer (B), and the water.

[0042] In some embodiments of the present invention, the weight-average molecular weight of the amphiphilic copolymer (B) ranges from 100,000 to 600,000. In one specific embodiment of the present invention, the weight-average molecular weight of the amphiphilic copolymer (B) is 100,000. In some embodiments of the present invention, the amount of the amphiphilic copolymer (B) is 0.01 wt% to 1.0 wt%, based on a total amount of 100 wt% of the amphiphilic copolymer (A), the amphiphilic copolymer (B), and the water. In one specific embodiment of the present invention, the amount of the amphiphilic copolymer (B) is 0.10 wt%, based on a total amount of 100 wt% of the amphiphilic copolymer (A), the amphiphilic copolymer (B), and the water.

[0043] In step (b), by performing the homogenization process, the lipophilic component containing lutein and zeaxanthin can be sufficiently mixed with the micelles in the first mixture, thereby embedding the lipophilic component into the lipophilic portion of the micelles, and thus obtaining the micelle complex containing lutein and zeaxanthin that can be dissolved in water. That is, the micelle complex can be dispersed in water and the second mixture is a homogeneous liquid.

[0044] The lipophilic component is used for eye care and can adhere to contact lenses, allowing the eyes to directly absorb the lipophilic component while wearing contact lenses, thereby enhancing the eye care effect. In some embodiments of the present invention, the concentration of lutein in the second mixture ranges from 1 ppm to 1000 ppm. In some embodiments of the present invention, the concentration of lutein in the second mixture ranges from 10 ppm to 100 ppm. In some embodiments of the present invention, to further enhance the eye care effect of the lipophilic component, the lipophilic component also includes meso-zeaxanthin. In some embodiments of the present invention, to further enhance the eye care effect of the lipophilic component, the ratio of lutein to zeaxanthin is 5:1.

[0045] It should be noted that the homogenization process in steps (a) to (b) is carried out under vacuum stirring or ultrasonic oscillation, which can promote the formation of micelles and enable the lipophilic component to be embedded into the lipophilic portion of the micelles.

[0046] In step (c), the moisturizing component is used to provide the contact lens with good moisturizing and lubricating properties for the eyes. In some embodiments of the present invention, the moisturizing component is selected from at least one of hyaluronic acid, tamarind gum, polyacrylic acid, carboxymethyl cellulose, dextran, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polysorbate 80, and alginate. In some embodiments of the present invention, based on 100 wt% of the total amount of the third mixture, the amount of the moisturizing component ranges from 0.01 wt% to 1 wt%. In some embodiments of the present invention, based on 100 wt% of the total amount of the third mixture, the amount of the moisturizing component ranges from 0.1 wt% to 0.5 wt%.

[0047] In some embodiments of the present invention, to further supplement the nutrients required for daily eye care, the functional component also includes a vitamin component. The vitamin component is, for example, but not limited to, vitamin A, B vitamins, vitamin C, vitamin D, vitamin E, and vitamin K. In some embodiments of the present invention, the vitamin component is selected from at least one of vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, niacin, and folic acid. In some embodiments of the present invention, the vitamin component is selected from at least one of vitamin A, vitamin B2, vitamin B6, and vitamin B12. The amount of each component in the vitamin component is not particularly limited and can be adjusted arbitrarily according to usage requirements. For example, but not limited to, in the contact lens preservation solution, the amount of vitamin A ranges from 1050 μg RE (i.e., 3496.5 IU) to 3000 μg. RE (i.e., 10000 I.U.); the dosage range of vitamin B1 is 1.95 mg to 50 mg; the dosage range of vitamin B2 is 2.25 mg to 100 mg; the dosage range of vitamin B6 is 2.1 mg to 80 mg; the dosage range of vitamin B12 is 3.6 μg to 1000 μg; the dosage range of vitamin C is 150 mg to 1000 mg; the dosage range of vitamin D is 15 μg (i.e., 600 I.U.) to 20 μg (i.e., 800 I.U.); the dosage range of vitamin E is 18 mg α-TE (i.e., 26.8 IU) to 268 mg α-TE (i.e., 400 I.U.); the dosage range of vitamin K is 140 μg to 500 μg; the dosage range of nicotinic acid is 25.5 mg N.E. to 100 mg NE; the dosage range of the folic acid is 600 μg to 800 μg.

[0048] In some embodiments of the present invention, when the vitamin component contains fat-soluble vitamins, the fat-soluble vitamins may be added together with the lipophilic component before step (b), and the water-soluble vitamins may be added before step (c).

[0049] In some embodiments of the present invention, to enable users to relieve or treat eye discomfort or symptoms while wearing contact lenses, the functional component further comprises a pharmaceutical component. In some embodiments of the present invention, the pharmaceutical component is selected from at least one of menthol, tyrosine, taurine, potassium L-aspartate, neostigmine methylsulfate, chlorpheniramine maleate, flavin adenine dinucleotide sodium, ε-Aminocaproic acid, dipotassium glycyrrhizate, zinc sulfate hydrate, berberine chloride hydrate, tetrahydrozoline, naphthazolline, chondroitin sulfate sodium, potassium chloride, and sodium chloride. There are no particular restrictions on the dosage of the drug components, which can be adjusted arbitrarily according to the needs of use.

[0050] In this invention, the functional components and the micelle complex are both dispersed in water after homogenization treatment, and the third mixture is a homogeneous liquid.

[0051] In step (d), adjusting the osmotic pressure and pH of the third mixture is to maintain the parameters of the contact lenses, thereby avoiding discomfort for the user when wearing them. In some embodiments of the invention, step (d) adjusts the osmotic pressure of the third mixture using at least one of sodium chloride and potassium chloride. In some embodiments of the invention, step (d) adjusts the pH of the third mixture using at least one of borate, phosphate, and carbonate. It should be noted that the osmotic pressure and pH are not particularly limited and can be adjusted according to the type of contact lenses. In some embodiments of the invention, the osmotic pressure ranges from 220 mOsmol / kg to 380 mOsmol / kg. In some embodiments of the invention, the osmotic pressure ranges from 250 mOsmol / kg to 350 mOsmol / kg. In a specific example of the invention, the osmotic pressure is preferably from 280 mOsmol / kg to 320 mOsmol / kg (i.e., 300 ± 20 mOsmol / kg). In some embodiments of the invention, the pH value ranges from 6.0 to 8.0. In one specific example of the invention, the pH value ranges from 7.2 to 7.6 (i.e., 7.4 ± 0.2).

[0052] In step (e), the homogenization process is to completely dissolve the substances in the fourth mixture to obtain a homogeneous liquid. The filtration process is to remove bacteria, incompletely dissolved particles, and airborne suspended particles from the fourth mixture resulting from the homogenization processes in steps (a) to (e).

[0053] In the preparation method of the contact lens preservation solution of the present invention, the micelles are formed by the amphiphilic copolymer (A) and the amphiphilic copolymer (B), and a homogenization treatment is performed to effectively encapsulate the lipophilic components containing lutein and zeaxanthin in the micelles, thereby improving the solubility of lutein and zeaxanthin in water, and thus allowing lutein and zeaxanthin to be completely dissolved in water to obtain a homogeneous contact lens preservation solution.

[0054] The present invention will be further described with reference to the following embodiments, but it should be understood that the embodiments are for illustrative purposes only and should not be construed as limiting the implementation of the present invention.

[0055] [Example 1]

[0056] 500 mL of copolymer (A) solution containing 1 wt% amphiphilic copolymer (A) (purchased from NOF Corporation, trade name Lipidure-LS, CAS number 1374749-63-9, weight average molecular weight of amphiphilic copolymer (A) 140,000) and 160 mL of copolymer (B) solution containing 5 wt% amphiphilic copolymer (B) (purchased from NOF Corporation, trade name Lipidure-LS) -NR, an amphiphilic copolymer (B) with a weight average molecular weight of 100,000, and 1340 mL of water were mixed and homogenized for 10 minutes to allow 0.25 wt% of the amphiphilic copolymer (A) and 0.4 wt% of the amphiphilic copolymer (B) to co-form micelles in water, obtaining a first mixture containing the micelles. Then, a lipophilic component containing lutein and zeaxanthin was added to the first mixture and homogenized for 1 hour to allow the lipophilic component to be coated within the micelles, forming a micelle complex containing lutein and zeaxanthin, obtaining a second mixture containing the micelle complex. In the lipophilic component, the ratio of lutein to zeaxanthin was 5:1, and the concentration of lutein in the second mixture was 1000 ppm. Then, a functional component containing moisturizing and vitamin components is added to the second mixture and homogenized for 1 hour to completely dissolve the functional component and the micelle complex, resulting in a third mixture. In the third mixture, the amount of the moisturizing component is 0.1 wt%, and the moisturizing component includes hyaluronic acid; the vitamin components include vitamin B2, vitamin B6, and vitamin B12. Next, the third mixture is poured into a 10-liter container, and sodium chloride is added to adjust the osmotic pressure of the third mixture, and phosphate or borate is added to adjust the pH value of the third mixture, resulting in a fourth mixture with an osmotic pressure of 300 ± 20 mOsmol / kg and a pH value of 7.4 ± 0.2. The fourth mixture was homogenized for 1 hour to ensure complete dissolution of the substances in the fourth mixture. Finally, the homogenized fourth mixture was filtered to obtain a contact lens preservation solution containing 0.05 mg of vitamin B2, 0.1 mg of vitamin B6, and 30 μg of vitamin B12. In Example 1, the homogenization was performed using a homogenizer (brand: [brand name missing]). Model: EUROSTAR 40digital). The homogenization process for obtaining the first and second mixtures is carried out under vacuum stirring or ultrasonic oscillation. The homogenizer performs homogenization by shear force, and there are no particular restrictions on the type of stirring rod used in the homogenizer, which can be replaced as needed.

[0057] [Comparative Example 1]

[0058] A lipophilic component containing lutein and zeaxanthin was mixed with water and homogenized for 1 hour to obtain a first mixture containing the lipophilic component. The ratio of lutein to zeaxanthin in the lipophilic component was 5:1, and the concentration of lutein in the first mixture was 1000 ppm. Then, a functional component containing moisturizing and vitamin components was added to the first mixture and homogenized for 1 hour to obtain a second mixture. In the second mixture, the amount of the moisturizing component was 0.1 wt%, and the moisturizing component included hyaluronic acid; the vitamin components included vitamin B2, vitamin B6, and vitamin B12. The second mixture was then poured into a 10-liter container, and sodium chloride was added to adjust the osmotic pressure of the second mixture, and phosphate or borate was added to adjust the pH value of the second mixture to obtain a third mixture with an osmotic pressure of 300 ± 20 mOsmol / kg and a pH value of 7.4 ± 0.2. The third mixture was homogenized for 1 hour, and then filtered to obtain a contact lens preservation solution containing 0.05 mg of vitamin B2, 0.1 mg of vitamin B6, and 30 μg of vitamin B12. In Comparative Example 1, homogenization was performed using a homogenizer (brand: [brand name missing]). Model: EUROSTAR 40digital.

[0059] [Comparative Example 2]

[0060] 500 mL of 0.2 wt% polyvinylpyrrolidone (as a comparative existing amphiphilic substance) and 1500 mL of water were mixed and homogenized for 10 minutes to allow the polyvinylpyrrolidone to form microcells in the water, obtaining a first mixture containing the microcells. Then, a lipophilic component containing lutein and zeaxanthin was added to the first mixture and homogenized for 1 hour to allow the lipophilic component to coat the microcells, forming a microcell complex containing lutein and zeaxanthin, obtaining a second mixture containing the microcell complex. In the lipophilic component, the ratio of lutein to zeaxanthin was 5:1, and the concentration of lutein in the second mixture was 1000 ppm. Then, a functional component containing moisturizing and vitamin components was added to the second mixture and homogenized for 1 hour to completely dissolve the functional component and the microcell complex, obtaining a third mixture. In the third mixture, the amount of the moisturizing component is 0.1 wt%, and the moisturizing component includes hyaluronic acid. The vitamin components include vitamin B2, vitamin B6, and vitamin B12. Then, the third mixture is poured into a 10-liter container, and sodium chloride is added to adjust the osmotic pressure of the third mixture, and phosphate or borate is added to adjust the pH value of the third mixture, obtaining a fourth mixture with an osmotic pressure of 300 ± 20 mOsmol / kg and a pH value of 7.4 ± 0.2. The fourth mixture is homogenized for 1 hour to completely dissolve the substances in the fourth mixture. Finally, the homogenized fourth mixture is filtered to obtain a contact lens preservation solution containing 0.05 mg of vitamin B2, 0.1 mg of vitamin B6, and 30 μg of vitamin B12. In Comparative Example 2, the homogenization process was performed using a homogenizer (brand: [brand name missing]). Model: EUROSTAR 40digital.

[0061] [Comparative Examples 3 to 5]

[0062] Comparative Examples 3 to 5 were obtained in a manner similar to that of Comparative Example 2, except that in Comparative Examples 3 to 5, 0.2 wt% of polyvinylpyrrolidone in Comparative Example 2 was replaced with 0.2 wt% of polyethylene glycol, 0.2 wt% of polysorbate 80, and 0.2 wt% of alginic acid as existing amphiphilic substances for comparison.

[0063] [Evaluation Items]

[0064] Precipitation of lipophilic components: The contact lens preservation solution of Example 1 was placed at 25°C for one week and the presence of precipitation and turbidity was observed. The contact lens preservation solutions of the other Comparative Examples 1 to 5 were subjected to the same method. The results are shown in Table 1.

[0065] Table 1

[0066]

[0067] To further confirm the precipitation status of the lipophilic component in the contact lens preservation solution of Example 1, the contact lens preservation solution of Example 1 was placed at 25°C for one month, three months, six months, nine months and twelve months, and the presence of precipitation and turbidity was observed. The results are shown in Table 2.

[0068] Table 2

[0069]

[0070] Referring to Table 1, by using the amphiphilic copolymer (A) and the amphiphilic copolymer (B) to form the micelles, the lipophilic components containing lutein and zeaxanthin can be coated on the lipophilic portion of the micelles and thus dissolve in water. Therefore, after one week of storage, no precipitation is formed in the contact lens preservation solution prepared by the method of Example 1, indicating that the lipophilic components containing lutein and zeaxanthin can dissolve well in it without precipitation. Therefore, when contact lenses preserved with the contact lens preservation solution are used subsequently, the lutein and zeaxanthin can be directly absorbed by the eyes by adsorbing onto the contact lenses.

[0071] In contrast, Comparative Examples 1 to 5: Comparative Example 1 did not use the amphiphilic copolymer (A) and the amphiphilic copolymer (B) to prepare the contact lens preservation solution. Therefore, after one week of storage, the contact lens preservation solution prepared by the method of Comparative Example 1 showed precipitation, indicating that the lipophilic components containing lutein and zeaxanthin could not dissolve and precipitated out. Comparative Examples 2 to 5 used amphiphilic substances such as polyvinylpyrrolidone, polyethylene glycol, polysorbate 80, and alginic acid to prepare the contact lens preservation solution, instead of using the amphiphilic copolymer (A) and the amphiphilic copolymer (B). Therefore, after one week of storage, the contact lens preservation solution prepared by the method of Comparative Examples 2 to 5 still showed precipitation, indicating that the use of the amphiphilic substances still could not improve the problem that the lipophilic components containing lutein and zeaxanthin could not dissolve in water.

[0072] Referring to Table 2, after storage for one month, three months, six months, nine months, and twelve months, no precipitation was observed in the contact lens preservation solution prepared by the method of Example 1. This indicates that the lipophilic components containing lutein and zeaxanthin can indeed dissolve well in the solution without precipitation, and that the preparation method of the contact lens preservation solution of the present invention can impart excellent dissolving effect to the lipophilic components in the prepared contact lens preservation solution.

[0073] In summary, the method for preparing the contact lens preservation solution of the present invention uses the amphiphilic copolymer (A) and the amphiphilic copolymer (B) to form micelles, and encapsulates the lipophilic components containing lutein and zeaxanthin in the lipophilic portion of the micelles. Therefore, the contact lens preservation solution prepared by the method of the present invention allows the lipophilic components containing lutein and zeaxanthin to be completely dissolved in it, and no precipitation occurs even after long-term storage, thus effectively achieving the purpose of the present invention. On the other hand, since the outer part of the micelles is composed of the hydrophilic portion, the micelle complex can be uniformly distributed on the lens surface of the contact lens through the hydrophilic portion. In addition, since lutein and zeaxanthin can absorb light in the wavelength range of 400nm to 500nm, and blue light has a wavelength range of 400nm to 500nm, the micelle complex distributed on the lens surface of the contact lens also has the effect of absorbing blue light, thereby giving the contact lenses stored in the contact lens preservation solution an anti-blue light effect.

[0074] However, the above description is merely an embodiment of the present invention and should not be construed as limiting the scope of the present invention. Any simple equivalent changes and modifications made in accordance with the claims and description of the present invention shall still fall within the scope of the patent of the present invention.

Claims

1. A method for preparing a preservation solution for contact lenses, characterized in that: The method for preparing the preservation solution for contact lenses includes the following steps: (a) Mixing and homogenizing amphiphilic copolymer (A), amphiphilic copolymer (B) and water to form micelles together, thereby obtaining a first mixture containing the micelles; (b) Add the lipophilic component containing lutein and zeaxanthin to the first mixture and homogenize it so that the lipophilic component is coated in the micelles to form a micelle complex containing lutein and zeaxanthin, and obtain a second mixture containing the micelle complex. (c) A functional component containing a moisturizing component is added to the second mixture and homogenized to completely dissolve the functional component and the micelle complex, thereby obtaining a third mixture; (d) Adjusting the osmotic pressure and pH value of the third mixture to obtain a fourth mixture; and (e) The fourth mixture is homogenized and filtered to obtain a preservation solution for contact lenses; The amphiphilic copolymer (A) has a structure as shown in formula (I). In the above formula (I), x is 100, y ranges from 10 to 400, and z ranges from 2 to 50; The amphiphilic copolymer (B) has a structure as shown in formula (II). In the above formula (II), with the sum of p and q being 100, p is 80 and q is 20.

2. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: The lipophilic component also includes meso-zeaxanthin.

3. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: The ratio of lutein to zeaxanthin is 5:

1.

4. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: The moisturizing component is selected from at least one of hyaluronic acid, tamarind gum, polyacrylic acid, carboxymethyl cellulose, dextran, hydroxypropyl methyl cellulose, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polysorbate 80, and alginate.

5. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: The functional components also include vitamin components.

6. The method for preparing the preservation solution for contact lenses according to claim 5, characterized in that: The vitamin components are selected from at least one of vitamin A, vitamin B1, vitamin B2, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, vitamin K, niacin, and folic acid.

7. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: The functional components also include pharmaceutical components.

8. The method for preparing the preservation solution for contact lenses according to claim 7, characterized in that: The drug component is selected from at least one of menthol, tyrosine, taurine, potassium L-aspartate, neostigmine methyl sulfate, chlorpheniramine maleate, sodium flavin adenine dinucleotide, ε-aminohexanoic acid, dipotassium glycyrrhizate, zinc sulfate hydrate, berberine hydrochloride hydrate, tetrahydrozoline, naphazoline, chondroitin sulfate sodium, potassium chloride, and sodium chloride.

9. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: Step (d) involves adjusting the osmotic pressure of the third mixture with at least one of sodium chloride and potassium chloride.

10. The method for preparing the preservation solution for contact lenses according to claim 1, characterized in that: Step (d) involves adjusting the pH of the third mixture with at least one of borate, phosphate, and carbonate.

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