A blood sample analyzer

Abstract

The application discloses a blood sample analyzer, and provides a blocking prevention module arranged at a liquid outlet of a reaction pool module. A filter screen type blocking prevention module is arranged at the liquid outlet of the first reaction pool module which receives the sample first, so that the impurity particles such as rubber debris can be physically intercepted at the source of the impurities, and the impurity particles are prevented from flowing into the rear small pipeline along with the sample, thereby reducing the incidence of pipeline blockage failure and making the liquid discharge process more smooth. A non-filter screen type blocking prevention module is arranged at the liquid outlet of the second reaction pool module except the first reaction pool module, so that the risk of pore blockage caused by long-term use of the filter screen can be reduced, the flow resistance is reduced, the liquid discharge efficiency is improved, and the equipment maintenance frequency and cost are reduced. The differential configuration can ensure the impurity interception effect of the key node and take into account the liquid discharge smoothness of the subsequent reaction pool, so that the stability and reliability of the overall analysis process are improved.

Description

Technical Field

[0001] This application relates to the field of sample analyzer technology, and in particular to a blood sample analyzer. Background Technology

[0002] In existing sample analyzers, rubber debris is easily generated when the sampling needle punctures the rubber cap of the sample tube to draw up the sample. This debris is added into the reaction cell along with the sample. Conventional reaction cell outlets do not have impurity interception structures, so debris can easily flow into the small downstream pipeline with the waste liquid and cause pipeline blockage, leading to problems such as poor drainage, cross-contamination of samples, and equipment alarm shutdown. Summary of the Invention

[0003] To address the aforementioned technical problems, this application provides a blood sample analyzer, comprising: The system consists of a sample distribution module, N reaction tank modules, and M anti-clogging modules, where M is greater than or equal to 2 and N is greater than or equal to M. The sampling module sequentially distributes samples to the N reaction cell modules; The M anti-clogging modules are each connected to the outlet of a corresponding reaction tank module; The N reaction tank modules include a first reaction tank module and a second reaction tank module, and the liquid outlet of the first reaction tank module and the liquid outlet of the second reaction tank module are both connected to the corresponding anti-clogging module. The first reaction cell module is the first reaction cell module to perform sample allocation during the process of the sample allocation module sequentially allocating samples to N reaction cell modules; The second reaction pool module is any one of the N reaction pool modules, excluding the first reaction pool module; The anti-clogging module connected to the first reaction tank module is of the filter type, and the anti-clogging module connected to the second reaction tank module is of the non-filter type. And / or, the first reaction cell module is closest to the sampling position.

[0004] The first anti-blocking module is the anti-blocking module connected to the first reaction tank module; The second anti-blocking module is the anti-blocking module connected to the last reaction cell module that is assigned a sample during the process of the sample distribution module sequentially distributing samples to the N reaction cell modules. The first anti-blocking module is of the common cavity type, and the second anti-blocking module is of the sleeve type. And / or, the first anti-blocking module is of the type with the drain port at the bottom, and the second anti-blocking module is of the type with the drain port in the center; And / or, the first anti-blocking module is of the side-through type, and the second anti-blocking module is of the straight-through type.

[0005] The anti-clogging module of the filter type includes a filter. The thickness of the filter screen is 6~11 mil; And / or, the number of rows per inch of the filter screen is 36±2 / in, and the number of columns per inch of the filter screen is 40±2 / in; And / or, the basis weight of the filter screen is 84.7~100 g / m²; And / or, the tensile strength of the filter screen is greater than 60 bs / in; And / or, the material of the filter is NET.

[0006] The filter-type anti-clogging module includes an anti-clogging tank and a filter screen; The blood sample analyzer further includes a first positive pressure drive module and a first negative pressure drive module. The anti-clogging tank includes an inlet, a positive pressure interface, and a negative pressure interface. The inlet is located at the top of the anti-clogging tank, and the positive pressure interface and the negative pressure interface are respectively located on the side wall of the anti-clogging tank. The inlet is connected to the outlet of the reaction tank module, the positive pressure interface is connected to the first positive pressure drive module, and the negative pressure interface is connected to the first negative pressure drive module. The filter screen is located inside the anti-clogging tank and between the positive pressure interface and the negative pressure interface. And / or, the filter screen is inclinedly disposed inside the anti-clogging tank, the edge of the filter screen abuts against the inner wall of the anti-clogging tank, and the angle between the filter screen and the horizontal plane is 30°~60°.

[0007] In the height direction of the anti-clogging tank, the positive pressure port is located above the negative pressure port; And / or, the anti-clogging module further includes a filter support, which is disposed inside the anti-clogging tank and located on the side of the filter away from the liquid inlet of the anti-clogging tank.

[0008] The blood sample analyzer also includes a first pipeline, a second positive pressure drive module and a second negative pressure drive module. The non-filter type anti-clogging module includes a three-way connector and a second pipeline. The first opening of the three-way connector is connected to the liquid outlet of the reaction tank module through the first pipeline, and the second opening of the three-way connector is connected to the second negative pressure drive module. The outer diameter of the second pipe is smaller than the inner diameter of the third opening of the tee joint. The first end of the second pipe is embedded in the tee joint through the third opening, and the second pipe is sealed to the third opening. The second end of the second pipe is connected to the second positive pressure drive module. The absolute value of the negative pressure at the drive end of the second negative pressure drive module is greater than 10 kPa.

[0009] The inner diameter of the second pipeline is greater than 0.05 mm; And / or, the difference between the inner diameter of the third opening and the outer diameter of the second pipe is greater than 0.1 mm.

[0010] Wherein, the first opening and the third opening are located on the same axis, the first end of the second pipe passes through the third opening and the first opening in sequence, and the distance of the first end of the second pipe beyond the first opening is 0.1~10mm; And / or, the first end of the second conduit is a free end or a semi-free end; And / or, the length of the pipe between the first end of the second pipe and the second pipe and the third opening seal is greater than 20 mm; And / or, the distance between the first end of the second pipeline and the outlet of the reaction tank module is less than 30 mm; And / or, the length of the first pipeline is less than 40 mm.

[0011] The inner volume of the transition cavity of the anti-blocking module is less than 4 ml; And / or, the inner volume of the transition cavity of the anti-blocking module connected to the first reaction cell module is greater than the inner volume of the transition cavity of the anti-blocking module connected to the last reaction cell module that is assigned a sample and connected to the anti-blocking module during the process of the sample distribution module sequentially distributing samples to N reaction cell modules.

[0012] The blood sample analyzer also includes a swab and a swab anti-clogging module. The swab is connected to the sample dispensing module and is used to clean the sampling needle of the sample dispensing module. The swab anti-clogging module is connected to the swab. Wherein, the inner cavity volume of the transition cavity of the swab anti-clogging module is greater than the inner cavity volume of the transition cavity of the anti-clogging module connected to the first reaction pool module; And / or, the swab anti-clogging module is a filter type, and the filter pore size in the filter type swab anti-clogging module is larger than the filter pore size in the filter type anti-clogging module.

[0013] The beneficial effects of this application are as follows: Unlike existing technologies, the blood sample analyzer provided in this application incorporates an anti-clogging module at the outlet of the reaction cell module. By installing a filter-type anti-clogging module at the outlet of the first reaction cell module that receives the first sample, impurity particles such as rubber debris and blood clots can be physically intercepted at the source of impurity generation, preventing them from flowing into the downstream fine tubing with the sample. This reduces the incidence of tubing blockage and makes the drainage process smoother. Installing a non-filter-type anti-clogging module at the outlet of the second reaction cell module (excluding the first reaction cell module) reduces the risk of pore blockage caused by long-term use of the filter, lowers flow resistance, improves drainage efficiency, and helps reduce equipment maintenance frequency and costs. This differentiated configuration allows the blood sample analyzer to ensure both effective impurity interception at critical nodes and smooth drainage from subsequent reaction cells, thereby improving the overall stability and reliability of the analysis process. Attached Figure Description

[0014] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Wherein: Figure 1 This is a schematic diagram of the structure of the first embodiment of the blood sample analyzer of this application; Figure 2 This is a schematic diagram of the structure of the second embodiment of the blood sample analyzer of this application; Figure 3 This is a schematic diagram of the structure of the third embodiment of the blood sample analyzer of this application; Figure 4 This is a schematic diagram of the structure of the fourth embodiment of the blood sample analyzer of this application; Figure 5 This is a schematic diagram of the structure of an embodiment of the anti-blocking module of this application; Figure 6 This is a schematic diagram of the fifth embodiment of the blood sample analyzer of this application.

[0015] Reference numerals: 1. Blood sample analyzer; 11. Reaction cell module; 12. Anti-clogging module; 121. Anti-clogging tank; 122. Liquid inlet; 123. Positive pressure interface; 124. Negative pressure interface; 125. Filter screen; 126. T-connector; 127. Second pipeline; 13. First pipeline; 14. Second positive pressure drive module; 15. Second negative pressure drive module. Detailed Implementation

[0016] The embodiments of this application will now be described in detail with reference to the accompanying drawings.

[0017] In the following description, specific details such as particular system architectures, interfaces, and technologies are presented for illustrative purposes rather than for limiting purposes, in order to provide a thorough understanding of this application.

[0018] In this application, the reference to "embodiment" means that a specific feature, structure, or characteristic described in connection with an embodiment may be included in at least one embodiment of this application. The appearance of this phrase in various places throughout the specification does not necessarily refer to the same embodiment, nor is it a separate or alternative embodiment mutually exclusive with other embodiments. It will be explicitly and implicitly understood by those skilled in the art that the embodiments described herein can be combined with other embodiments.

[0019] In this application, the term "and / or" is merely a description of the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent three cases: A alone, A and B simultaneously, and B alone. Additionally, the character " / " generally indicates that the preceding and following related objects are in an "or" relationship. Furthermore, "many" in this application means two or more. Moreover, the term "at least one" in this application means any combination of at least two of any one or more of a plurality of objects. For example, including at least one of A, B, and C can mean including any one or more elements selected from the set consisting of A, B, and C. Furthermore, the terms "first," "second," and "third" in this application are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features.

[0020] The blood sample analyzer provided in this application includes a sample separation module, N reaction cell modules, and M anti-clogging modules, wherein M is greater than or equal to 2, and N is greater than or equal to M. For example, the blood sample analyzer may include two anti-clogging modules and two or more reaction cell modules. Each reaction cell module can correspond to the reaction site of the detection solution for one detection item, and different reaction cell modules correspond to different detection items.

[0021] The sample allocation module sequentially distributes samples to N reaction cell modules. The allocation can be based on the distance from the module itself, meaning the reaction cell closest to the module receives samples first, and the farthest receives samples last. Alternatively, the allocation order can be determined by the detection time of the corresponding test for each reaction cell module; the reaction cell with the longest detection time receives samples first, and so on. This ensures that the reaction cell module that receives samples first can perform its operation first, guaranteeing that when multiple tests are performed on the same sample in the blood analyzer, these tests can be completed almost simultaneously, ensuring high efficiency. This application does not specify a particular order for the sample allocation module to distribute samples to the N reaction cell modules; it can be configured based on user needs.

[0022] Next, M anti-clogging modules are each connected to the outlet of a corresponding reaction tank module, such as... Figure 1 As shown, the anti-clogging module 12 can be connected to the outlet of the reaction tank module 11. The N reaction tank modules 11 include a first reaction tank module and a second reaction tank module. The outlets of both the first and second reaction tank modules are connected to corresponding anti-clogging modules 12. The first reaction tank module is the first one to distribute samples among the N reaction tank modules 11 during the sample distribution process. The second reaction tank module is any one of the N reaction tank modules 11 except for the first reaction tank module. The anti-clogging module 12 connected to the first reaction tank module is a filter type, while the anti-clogging module 12 connected to the second reaction tank module is a non-filter type.

[0023] The reaction chamber module 11 is a container for sample reaction. Each reaction chamber module 11 has an outlet for discharging waste liquid or test liquid after the reaction. In practice, when collecting samples, the sampling needle of the sample dispensing module pierces the sample cap of the sample tube to enter the sample tube. That is, the sampling needle may contain rubber fragments from the sample cap, blood clots, or other impurities. These impurities may be distributed to the reaction chamber module 11 along with the sampling needle and then enter the reaction chamber module 11, subsequently clogging the subsequent liquid pipeline as they are discharged from the reaction chamber module 11 with the waste liquid or test liquid. To solve this problem, this embodiment of the application installs an anti-clogging module 12 at the outlet of the reaction chamber module 11. The anti-clogging module 12 is used to filter impurities in the liquid or break up impurities that may clog the pipeline, thereby ensuring smooth flow of liquid in the pipeline.

[0024] Specifically, in this embodiment, M anti-blocking modules 12 are respectively connected to the liquid outlets of M different reaction pool modules 11, and the number of N is greater than or equal to M. This means that not all reaction pool modules 11 are equipped with anti-blocking modules 12, but are configured for specific key reaction pools.

[0025] The filter-type anti-clogging module 12 contains a filter medium with a specific pore size, such as a metal mesh or nylon mesh, which can physically intercept tiny impurity particles. The non-filter-type anti-clogging module 12 does not rely on fine filter media and may employ structural blocking, negative pressure suction combined with coarse filtration, or a pure flow channel design. This differentiated design is based on the varying risk of impurity particles when the sample enters different reaction cells. In blood sample analysis, rubber debris generated by the sampling needle piercing the rubber cap is the main source of impurities. The first reaction cell module, being the first to receive the sample, directly faces the raw sample stream without any pretreatment, resulting in the highest concentration of rubber debris and the greatest risk. Therefore, the filter-type anti-clogging module 12 is used for source interception. Subsequent reaction cell modules 11 may receive samples that have been mixed or diluted, or their corresponding detection items may have low sensitivity to tiny particles, or the system may have already reduced the impurity load at the front end. Therefore, the non-filter-type anti-clogging module 12 is used, providing some anti-clogging functionality while reducing flow resistance, improving drainage efficiency, and reducing maintenance costs.

[0026] In practice, impurity particles on the sample distribution module have a high probability of falling off due to gravity caused by movement and vibration in various directions. Therefore, the probability of falling off is extremely high in the early stages (the first few reaction cell modules, especially the first reaction cell module) and low in the later stages (the later reaction cell modules, especially the last reaction cell module). As long as the impurity particles that fall off in the early stages are properly handled, the failure rate of the entire machine caused by impurity particle blockage can be greatly reduced. Therefore, in the early stages (such as the first reaction cell module that distributes samples), a treatment solution with good processing effect but potentially higher cost (filter-type anti-clogging module 12) can be used, while in the later stages (such as the second reaction cell module that distributes samples later), a treatment solution with moderate processing effect but lower cost (non-filter-type anti-clogging module 12) can be used.

[0027] In some embodiments, the inner diameter of the outlet of the reaction tank module 11 can be greater than 0.5 mm to avoid impurity particles from clogging the outlet of the reaction tank module 11 and affecting subsequent operations.

[0028] In some embodiments, please refer to Figure 2 , Figure 2 The reaction tank module 11 shown is the first reaction tank module described above, and the anti-clogging module 12 connected to the first reaction tank module is a filter type, such as... Figure 2As shown, the anti-clogging module 12 can be specifically designed with a filter structure in the tank to filter impurity particles, improve the filtration capacity of impurity particles in the liquid discharged from the first reaction tank module, effectively capture impurity particles, and prevent them from entering the downstream fine pipeline.

[0029] In some embodiments, two or more of the N reaction tank modules 11 may have their outlets connected to the filter-type anti-clogging module 12. It is understood that the filter structure has good filtration efficiency, and the filter pore size can be set so that impurities larger than the filter pore size can be filtered out cleanly, preventing blockage of subsequent pipelines and avoiding major anomalies. Furthermore, the filter pore size can be smaller than the components to be tested in the blood (such as blood cells or antigens / antibodies), allowing these components to pass easily through the filter structure without affecting subsequent testing. Therefore, the filter pore sizes in multiple filter-type anti-clogging modules 12 can be different; using a larger pore size treatment scheme initially and a smaller pore size treatment scheme later can achieve better filtration and anti-clogging effects.

[0030] In some embodiments, please refer to Figure 3 , Figure 3 The reaction tank module 11 shown is the second reaction tank module described above. The anti-clogging module 12 connected to the second reaction tank module is a non-filter type, such as... Figure 3 As shown, the anti-clogging module 12 can be specifically a tank without a filter structure, used to expand the subsequent flow space of the outlet of the second reaction tank module, promote the discharge efficiency of impurity particles, avoid impurity particles from clogging the subsequent pipeline, and ensure smooth discharge.

[0031] In some embodiments, please refer to Figure 4 The non-filter type anti-clogging module 12 can also adopt a three-way connector structure, and another small pipe runs through the three-way connector. This small pipe can introduce positive pressure during the drainage process to slow down the flow rate of the drained liquid and the flow rate of impurity particles in the liquid. At the same time, it applies additional force to the impurity particles in the liquid to prevent the impurity particles from clogging the pipe with the flow and ensure smooth drainage.

[0032] In some embodiments, the first reaction cell module is closest to the sampling position, where the sampling position refers to the location where the sample distribution module collects samples. Specifically, it can be set at intervals with the N reaction cell modules 11. Thus, the sample distribution module can allocate samples to the N reaction cell modules in order of their distance from the sampling position. The reaction cell module closest to the sampling position (the first reaction cell module) is allocated samples first, while the reaction cell module farthest from the sampling position is allocated samples last.

[0033] By installing a filter-type anti-clogging module 12 at the outlet of the first reaction chamber module that receives the first sample, impurity particles such as rubber fragments can be physically intercepted at the source of impurity generation, preventing them from flowing into the downstream fine tubing with the sample. This reduces the incidence of tubing blockage and makes the drainage process smoother. Installing a non-filter-type anti-clogging module 12 at the outlet of any second reaction chamber module other than the first reaction chamber module reduces the risk of pore blockage caused by long-term use of the filter 125, lowers flow resistance, improves drainage efficiency, and also helps reduce equipment maintenance frequency and costs. This differentiated configuration allows the blood sample analyzer 1 to ensure the effectiveness of impurity interception at critical nodes while also ensuring smooth drainage from subsequent reaction chambers, thereby improving the stability and reliability of the overall analysis process.

[0034] Optionally, the first anti-clogging module is the anti-clogging module 12 connected to the first reaction cell module, and the second anti-clogging module is the anti-clogging module 12 connected to the reaction cell module 11 that is the last to distribute samples during the process of the sample distribution module sequentially distributing samples to N reaction cell modules 11. Therefore, the first anti-clogging module is the anti-clogging module 12 connected to the first reaction cell module, which is a filter-type anti-clogging module 12. The second anti-clogging module is the anti-clogging module 12 connected to the second reaction cell module that is the last to distribute samples, and can be a non-filter-type anti-clogging module 12.

[0035] The sample distribution module sequentially distributes blood samples into N reaction pool modules 11 according to a preset program, with at least two of these reaction pool modules 11 equipped with anti-blocking modules 12. The first reaction pool module is the first reaction pool to receive samples after they enter the analysis system, and its connected anti-blocking module 12 is defined as the first anti-blocking module. The second reaction pool module is the last reaction pool to receive samples after the sample flow has passed through a series of reaction pools, and its connected anti-blocking module 12 is defined as the second anti-blocking module. This differentiated design, with corresponding modules at each end, is based on the state changes of the sample during flow and the functional characteristics of different anti-blocking structures.

[0036] In some embodiments, the first anti-blocking module is of the common cavity type, and the second anti-blocking module is of the sleeve type. Figure 2The anti-clogging module 12 shown is a common-cavity anti-clogging module 12. The common-cavity anti-clogging module 12 consists of a housing forming a sealed cavity. The inlet, positive pressure port, and negative pressure port are all connected to this sealed cavity. The inlet is connected to the outlet of the reaction tank module 11, while the positive pressure port is connected to a positive pressure source to provide positive pressure to the sealed cavity. The negative pressure port is connected to a negative pressure source to provide negative pressure to the sealed cavity, allowing the liquid in the sealed cavity to be discharged through the negative pressure port. A filter structure is installed between the positive and negative pressure ports so that the liquid entering from the inlet is filtered by the positive pressure pushing and the negative pressure drawing it in. Specifically, the filtration structure can divide the sealed cavity into a first cavity near the positive pressure port and a second cavity near the negative pressure port. The liquid enters the first cavity through the inlet, and then, under the action of positive pressure, it passes through the filter structure into the second cavity. Impurities mixed in the liquid are filtered by the filter structure and retained in the first cavity. The filtered liquid is then discharged through the negative pressure port.

[0037] like Figure 3 The anti-clogging module 12 shown is a sleeve-type anti-clogging module 12, which mainly consists of an outer sleeve and an inner pipeline. The inner pipeline is installed inside the outer sleeve, so that the outer wall of the inner pipeline and the inner wall of the outer sleeve form an annular sandwich flow channel. The inner pipeline is a pressure medium passage, and one end of the inner pipeline is connected to a positive pressure source, which can introduce positive pressure medium into the inlet end of the annular sandwich flow channel. During operation, when the liquid enters the annular sandwich flow channel, positive pressure is introduced into the inlet end of the annular sandwich flow channel through the inner pipeline for purging, so as to slow down the flow rate of the liquid and impurity particles in the liquid, block and reduce the deposition of impurity particles, and avoid the blockage of the flow channel, thereby completing the anti-clogging function of the liquid path. It can be understood that in this anti-clogging module 12, the inner pipeline does not have a filter structure. Specifically, the sleeve-type anti-clogging module 12 may include a tee connector and an inner pipe embedded in the tee connector. The first end of the tee connector is connected to the liquid outlet of the reaction tank module 11. The inner pipe is embedded in the tee connector through the second end of the tee connector, and the end of the inner pipe away from the positive pressure source is set at the first end of the tee connector, so that positive pressure can be supplied to the first end of the tee connector to avoid impurity particles from causing blockage at the first end of the tee connector. The third end of the tee connector can be connected to a negative pressure source, and the liquid can be discharged through the third end of the tee connector.

[0038] In some embodiments, the first anti-clogging module is of the type with the drain port at the bottom, while the second anti-clogging module is of the type with the drain port in the middle. The drain port can be defined as the interface connecting the anti-clogging module 12 to the negative pressure source. Please continue reading. Figure 2 and Figure 3 The drain port of the first anti-clogging module is also Figure 2In the negative pressure interface, the first anti-clogging module has a lower drain port, meaning the positive pressure interface and inlet are above the negative pressure interface. Liquid can also pass through the filter structure and be discharged through the negative pressure interface under gravity, improving discharge efficiency. The second anti-clogging module has a centrally located drain port, meaning the third end of the three-way connector is located between the first and second ends. This allows liquid to be discharged nearby, shortening the settling path of impurities and reducing dead zones.

[0039] In some embodiments, the first anti-blocking module is a side-through type, and the second anti-blocking module is a straight-through type. Here, the type defines the location where the anti-blocking module 12 is connected to the positive pressure source. Please continue reading. Figure 2 and Figure 3 The positive pressure interface of the first anti-clogging module is located on the side wall of the housing and is connected to a positive pressure source, thus the first anti-clogging module is a side-through type. In the second anti-clogging module, the positive pressure source is connected to the internal pipeline, which passes directly through the tee connector without any folds, thus the second anti-clogging module is a straight-through type.

[0040] Optionally, the filter-type anti-clogging module 12 includes a filter 125, wherein the thickness of the filter 125 is 6~11 mil; and / or, the number of rows per inch of the filter 125 is 36±2 / in, and the number of columns per inch of the filter 125 is 40±2 / in; and / or, the basis weight of the filter 125 is 84.7~100 g / m²; and / or, the tensile strength of the filter 125 is greater than 60 bs / in; and / or, the material of the filter 125 is NET.

[0041] In some embodiments, the thickness of the filter 125 is set to 6-11 mil, or 0.6 to 0.11 inches, which ensures sufficient structural strength while minimizing flow resistance and dead volume during fluid passage.

[0042] In some embodiments, the filter screen 125 has 36 ± 2 rows per inch and 40 ± 2 rows per inch. These two parameters together determine the mesh density and pore size of the filter screen 125, enabling it to form a uniform and stable filter mesh that effectively intercepts tiny impurity particles such as rubber debris. For example, the filter screen 125 may have 36 rows per inch and 40 rows per inch; or it may have 36 rows per inch and 41 rows per inch, etc., which can be set by the user based on actual needs.

[0043] In some embodiments, the basis weight of the filter screen 125 is controlled between 84.7 and 100 g / m², for example, the basis weight of the filter screen 125 is 84.7, 85, 90, or 100 g / m², which reflects the unit area mass of the filter screen material and indirectly reflects the density and material usage of the filter screen 125. By limiting the basis weight of the filter screen 125, the structural strength, dirt-holding capacity, and fluid flow resistance of the filter screen 125 can be balanced. This avoids the filter screen 125 from being stretched and deformed by fluid pressure, causing filter penetration, and also prevents the filter screen 125 from clogging prematurely. At the same time, it improves the assembly processability and ensures the consistency of performance of batch parts.

[0044] In some embodiments, the tensile strength of the filter screen 125 is greater than 60 bs / in, ensuring that the filter screen 125 is not easily deformed or broken when subjected to stress generated by positive pressure flushing or negative pressure suction.

[0045] In some embodiments, the filter screen 125 is made of NET material, which is a woven mesh filter material. It is a mesh filter component formed by weaving polymer monofilaments. This filter material has excellent chemical stability and corrosion resistance, can be adapted to various cleaning fluid conditions, and has good biocompatibility. When in contact with blood samples, it can reduce non-specific adsorption and is used to intercept impurity particles inside the liquid path.

[0046] In some embodiments, the mesh of the filter 125 can also be set as an irregularly shaped mesh with inconsistent sizes; compared with a filter structure with uniform and regular mesh, this type of mesh structure has more diverse force directions, and the stress under fluid impact can be dispersed and released, which can suppress local stress concentration of the filter 125, reduce the risk of filter 125 being deformed by pressure and tension and mesh distortion, and maintain the stability of the filter 125's filtration and interception capabilities.

[0047] In some embodiments, a filter screen 125 with a thickness of 8 mil, a row count of 36 / in, a row count of 40 / in, a basis weight of 90 g / m², a tensile strength of 65 bs / in, and made of NET can be selected. Alternatively, a filter screen 125 with a thickness of 6 mil, a row count of 38 / in, a row count of 42 / in, a basis weight of 85 g / m², a tensile strength of 62 bs / in, and made of NET can also be selected. Furthermore, a filter screen 125 with a thickness of 11 mil, a row count of 34 / in, a row count of 38 / in, a basis weight of 100 g / m², a tensile strength of 68 bs / in, and made of NET can be selected. This combination of parameters achieves an optimal balance between interception efficiency, flow capacity, and durability for the filter screen 125.

[0048] By setting the thickness of filter screen 125 to 6~11 mil, filter screen 125 provides sufficient mechanical support while reducing fluid resistance, which is beneficial for improving drainage speed and reducing sample residue. By setting the number of rows per inch (L) of filter screen 125 to 36±2 / in and the number of columns per inch (W) to 40±2 / in, filter screen 125 forms a mesh structure with a specific pore size, which can accurately intercept impurity particles larger than the mesh size, while avoiding rapid clogging caused by excessively small mesh size, thus achieving a balance between efficient impurity interception and fluid passage. By setting the basis weight of filter screen 125 to 84.7~100 g / m², filter screen 125 has suitable density and strength, which is beneficial for ensuring the stability and consistency of filtration effect. By setting the tensile strength of filter screen 125 to be greater than 60 bs / in, filter screen 125 maintains structural integrity when subjected to alternating positive and negative pressure loads and mechanical cleaning forces for a long time, and is not prone to breakage or deformation, thereby extending the service life of anti-clogging module 12. By setting the material of filter 125 to NET, filter 125 has good chemical corrosion resistance and biological inertness, avoiding reaction with blood samples or cleaning solutions, which helps to prevent cross-contamination of samples and ensure the accuracy of analysis results.

[0049] Optional, please refer to the following: Figure 2 and Figure 5 The filter-type anti-clogging module 12 includes an anti-clogging tank 121 and a filter 125. The anti-clogging tank 121 includes an inlet 122, a positive pressure interface 123, and a negative pressure interface 124. The blood sample analyzer 1 also includes a first positive pressure drive module and a first negative pressure drive module (not shown in the figure).

[0050] The inlet 122 is located at the top of the anti-clogging tank 121, while the positive pressure port 123 and negative pressure port 124 are located on the side wall of the anti-clogging tank 121. The inlet 122 is connected to the outlet of the reaction tank module 11, the positive pressure port 123 is connected to the first positive pressure drive module, and the negative pressure port 124 is connected to the first negative pressure drive module. The filter screen 125 is located inside the anti-clogging tank 121, between the positive pressure port 123 and the negative pressure port 124.

[0051] The anti-clogging tank 121 serves as a container and support component, and its interior is equipped with a filter screen 125 to filter impurities. The inlet 122 of the anti-clogging tank 121 is located at the top and connected to the outlet of the reaction tank module 11, ensuring that the liquid discharged from the reaction tank can smoothly enter the anti-clogging tank 121. The side walls of the anti-clogging tank 121 are respectively provided with a positive pressure interface 123 and a negative pressure interface 124. The positive pressure interface 123 is connected to a first positive pressure drive module, and the negative pressure interface 124 is connected to a first negative pressure drive module. This dual-side drive connection allows a positive and / or negative pressure environment to be formed inside the anti-clogging tank 121, enabling cleaning or drainage operations in conjunction with the filter screen 125.

[0052] Specifically, after the liquid enters the anti-clogging tank 121 through the outlet of the reaction tank module 11 and the inlet 122 of the anti-clogging tank 121, the first positive pressure drive module can supply positive pressure to the anti-clogging tank 121 through the positive pressure interface 123, so that the liquid can pass through the filter screen 125 under the action of positive pressure. The filter screen 125 can filter out impurity particles mixed in the liquid. The first negative pressure drive module can supply negative pressure to the anti-clogging tank 121 through the negative pressure interface 124, so that the liquid can be discharged through the negative pressure interface 124 under the action of negative pressure. Since the filter screen 125 is set between the positive pressure interface 123 and the negative pressure interface 124, the liquid in the anti-clogging tank 121 will definitely be filtered by the filter screen 125 before being discharged, ensuring the filtration efficiency of the anti-clogging module 12 for impurity particles in the liquid.

[0053] In some embodiments, the filter screen 125 may be inclinedly disposed within the anti-clogging tank 121, with the edge of the filter screen 125 abutting against the inner wall of the anti-clogging tank 121, and the angle between the filter screen 125 and the horizontal plane being 30° to 60°. By distributing the filter screen 125 in an inclined manner within the anti-clogging tank 121, filtered impurity particles accumulate at the lower end of the filter screen 125, rather than being scattered throughout the plane of the filter screen 125, thus preventing clogging of the filter screen 125 pores and affecting filtration efficiency. The angle between the filter screen 125 and the horizontal plane is set to 30° to 60°, preferably including angles such as 30°, 40°, 45°, 50°, or 60°. Furthermore, its edge tightly abuts against the inner wall of the anti-clogging tank 121, forming a sealed fit to prevent liquid leakage from the edge.

[0054] In some embodiments, the anti-clogging tank 121 is a cylindrical or square plastic shell, and the liquid inlet 122 is located at the center or off-center of the top of the shell. The filter screen 125 is fixed to the inner wall of the anti-clogging tank 121 by welding, bonding or snap-fitting.

[0055] In some embodiments, the first positive pressure drive module may be an air pump or a solenoid valve assembly for injecting compressed air into the anti-clogging tank 121; the first negative pressure drive module may be a vacuum pump or a negative pressure source interface for extracting gas from the anti-clogging tank 121 to generate suction.

[0056] By providing an inlet 122 at the top of the anti-clogging tank 121 and connecting it to the outlet of the reaction tank, waste liquid flows into the anti-clogging tank 121 by gravity, reducing flow resistance and preventing air bubble retention. By providing a positive pressure port 123 and a negative pressure port 124, each connected to a drive module, a controllable pressure environment can be created inside the anti-clogging tank 121. By tilting the filter screen 125 with its edges abutting against the inner wall, the filter screen 125 has a stable installation structure, preventing displacement or leakage caused by vibration. Simultaneously, the tilted structure allows impurity particles to easily slide to the bottom of the tank under gravity or airflow, improving impurity interception efficiency. By limiting the angle between the filter screen 125 and the horizontal plane to 30°~60°, a balance is achieved between the interception area and the ease of impurity sliding off. This ensures sufficient filtration area while utilizing gravity to assist in the detachment of impurity particles, thereby improving drainage smoothness and reducing the risk of clogging.

[0057] Optionally, in the height direction of the anti-clogging tank 121, the positive pressure port 123 is located above the negative pressure port 124.

[0058] Specifically, by placing the positive pressure port 123 above the negative pressure port 124, the height difference creates a more defined airflow path for the positive pressure gas and the negative pressure suction airflow within the tank. With the positive pressure port 123 at the top, high-pressure gas is injected from above and blown downwards when the first positive pressure drive module is operating; conversely, with the negative pressure port 124 at the bottom, vacuum suction is drawn from below and pulled upwards when the negative pressure drive module is operating. This vertically distributed airflow design facilitates the formation of a top-down convection or negative pressure field within the tank, enhancing airflow coverage of the filter 125 surface and surrounding space.

[0059] In some embodiments, the positive pressure port 123 and the negative pressure port 124 may be located at different heights on the same vertical plane of the anti-clogging tank 121, or at different heights on different vertical planes of the anti-clogging tank 121, with a certain distance between them in the vertical direction, such as 10mm to 30mm, to optimize the airflow path.

[0060] In some embodiments, as described above, the filter screen 125 is inclined in the anti-clogging tank 121, and the positive pressure port 123 can be located directly above the highest point of the inclined filter screen 125. Then, the positive pressure introduced by the first positive pressure drive module through the positive pressure port 123 can also blow away the impurity particles on the filter screen 125, so that the impurity particles on the filter screen 125 move towards the lowest point of the inclined filter screen 125 under the action of positive pressure, which helps to blow off the impurity particles intercepted on the filter screen 125.

[0061] In some embodiments, the anti-clogging module 12 further includes a filter support (not shown), which is disposed inside the anti-clogging tank 121 and located on the side of the filter 125 away from the liquid inlet 122 of the anti-clogging tank 121. Specifically, one end of the filter support abuts against the inner bottom surface of the anti-clogging tank 121, and the other end of the filter support abuts against the filter 125, for supporting or fixing the filter 125 from below, bearing the weight of the filter 125 and the pressure difference when liquid passes through, and preventing the filter 125 from sagging, deforming or breaking. It is understood that when the filter 125 is tilted, the filter support is also used to support the tilted setting of the filter 125.

[0062] In some embodiments, the filter support may be a mesh support, annular protrusion, or rod-shaped structure, and its material may be plastic, metal, or ceramic, and it must have sufficient strength and corrosion resistance.

[0063] In some embodiments, the filter support can be an annular support ring that matches the edge of the filter 125 and is fixed to the inner wall of the anti-clogging tank 121 by welding or snap-fit. The support ring is located below the filter 125 to ensure that the filter 125 remains horizontal or at a preset tilt angle.

[0064] By positioning the positive pressure port 123 above the negative pressure port 124, positive pressure airflow is injected from top to bottom, while negative pressure suction is drawn from bottom to top, creating a directional convection airflow within the anti-clogging tank 121. This facilitates the blowing off of impurities trapped on the filter screen 125 and their rapid discharge through the negative pressure port 124, improving self-cleaning efficiency and reducing the residue of impurities within the tank. By positioning the filter screen support on the side of the filter screen 125 away from the liquid inlet 122 (i.e., below or behind the filter screen 125), the support effectively supports the filter screen 125, allowing it to withstand liquid static pressure and pressure differential. This prevents the filter screen 125 from deforming or collapsing due to prolonged immersion or pressure, ensuring the stability of the filter screen 125's filtration performance and extending its service life.

[0065] Optional, such as Figure 6 As shown, the blood sample analyzer 1 also includes a first pipeline 13, a second positive pressure drive module 14 and a second negative pressure drive module 15, and a non-filter type anti-clogging module 12 including a tee connector 126 and a second pipeline 127.

[0066] The first opening of the tee connector 126 is connected to the outlet of the reaction tank module 11 through the first pipe 13, and the second opening of the tee connector 126 is connected to the second negative pressure drive module 15. The outer diameter of the second pipe 127 is smaller than the inner diameter of the third opening of the tee connector 126. The first end of the second pipe 127 is embedded in the tee connector 126 through the third opening, and the second pipe 127 is sealed to the third opening. The second end of the second pipe 127 is connected to the second positive pressure drive module 14.

[0067] The core component of the non-filter type anti-clogging module 12 is a three-way connector 126, which has a first opening, a second opening, and a third opening. The first opening of the three-way connector 126 is connected to the liquid outlet of the reaction tank module 11 through the first pipeline 13, so that the liquid in the reaction tank module 11 can flow into the three-way connector 126. The second opening of the three-way connector 126 is connected to the second negative pressure drive module 15 to provide negative pressure suction power.

[0068] The outer diameter of the second pipe 127 is smaller than the inner diameter of the third opening of the tee connector 126. The first end of the second pipe 127 is inserted into the tee connector 126 through the third opening, and the second end of the second pipe 127 is connected to the second positive pressure drive module 14 to provide positive pressure purging power. The second pipe 127 is sealed to the third opening to ensure that liquid does not leak at the third opening.

[0069] During operation, when the liquid in the reaction tank module 11 needs to be discharged, the second negative pressure drive module 15 is activated, generating negative pressure through the second opening of the three-way connector 126, discharging the liquid from the first opening through the second opening of the three-way connector 126. Simultaneously, the second positive pressure drive module 14 is activated, providing positive pressure to the inside of the three-way connector 126 through the second pipe 127 to generate bubbles. These bubbles exert a force opposite to the flow direction on the flowing liquid, and also impact impurity particles, slowing down the flow speed of the liquid and the impurity particles within it. Furthermore, if impurity particles are present in the liquid, the bubbles can change their flow direction through impact, causing them to flow in random directions through the annular flow channel formed between the second pipe 127 and the three-way connector 126. This prevents impurity particles from flowing too quickly and in the same direction, thus avoiding blockage at a certain point, and achieving the anti-blocking function of the anti-blocking module 12.

[0070] In some embodiments, the absolute value of the negative pressure at the drive end of the second negative pressure drive module 15 is greater than 10 kPa, such as 15 kPa, 20 kPa or higher, and the specific value can be set according to the actual drainage requirements and pipeline resistance.

[0071] In some embodiments, the second conduit 127 can be a flexible hose or a rigid tube, and the material can be PVC, silicone or polytetrafluoroethylene, etc., as long as the outer diameter of the tube is smaller than the inner diameter of the third opening of the tee connector 126 and a sealed connection can be achieved.

[0072] In some embodiments, a thin tube with an inner diameter of 0.1 mm to 0.5 mm can be selected as the second conduit 127, and its outer diameter is slightly smaller than the inner diameter of the third opening of the tee connector 126, for example, the difference is 0.1 mm to 0.5 mm, to ensure a tight fit.

[0073] In some embodiments, a sealed connection between the second conduit 127 and the third opening can be achieved by means of interference fit, adhesive bonding, or heat shrink tubing. Preferably, heat shrink tubing is fitted over the third opening and the second conduit 127 to facilitate installation and accommodate minor positional deviations.

[0074] By incorporating a non-filter-type anti-clogging module 12, including a tee connector 126 and a second pipe 127, and using a structure where the second pipe 127 is embedded in and sealed within the third opening of the tee connector 126, a compact connection between the positive pressure drive module and the tee connector 126 is achieved. This reduces the use of external piping, lowers installation complexity, and reduces the risk of leakage. The outer diameter of the second pipe 127 is smaller than the inner diameter of the third opening of the tee connector 126, allowing the positive pressure to act directly on the inside of the tee connector 126, improving the efficiency and coverage of positive pressure purging and helping to prevent blockage. The second negative pressure drive module 15 has a negative pressure absolute value greater than 10 kPa at its drive end, providing sufficient suction force to ensure that the liquid in the reaction tank module 11 can be quickly and thoroughly discharged. This reduces the residence time of the liquid in the pipes, thereby reducing the risk of impurity particle sedimentation and blockage caused by liquid stasis, and improving drainage speed and efficiency. This non-filter structure can effectively prevent pipeline blockage through hydrodynamic means without the need for fine filter media, reducing maintenance costs, extending equipment lifespan, and ensuring the continuity and accuracy of sample analysis.

[0075] In some embodiments, the inner diameter of the second conduit 127 is greater than 0.05 mm.

[0076] The inner diameter of the second pipe 127 is greater than 0.05 mm, and can be a specific value such as 0.06 mm or 0.07 mm, in order to reduce the pressure drop along the friction in the second pipe 127, so that the positive pressure output in the second end of the second pipe 127 is larger, which can provide a greater force on the impurity particles. When facing larger impurity particles, it can also change the flow velocity and flow direction of the impurity particles.

[0077] In some embodiments, the inner diameter of the second conduit 127 is no greater than 0.5 mm, so that the second conduit 127 is classified as a thin tube, ensuring that the second conduit 127 can be smoothly embedded into the tee connector 126.

[0078] Optionally, the difference between the inner diameter of the third opening and the outer diameter of the second pipe 127 is greater than 0.1 mm.

[0079] The difference between the inner diameter of the third opening and the outer diameter of the second pipe 127 determines the size of the radial gap formed when the second pipe 127 is embedded in the third opening of the tee connector 126. This makes the volume of the second pipe 127 inserted into the tee connector 126 smaller than the volume of the receiving cavity inside the tee connector 126, which facilitates the installation of the second pipe 127, reduces installation costs and time, and facilitates the sealing connection, reducing the possibility of pipe leakage.

[0080] For example, if the outer diameter of the second pipe 127 is 0.8 mm, then the inner diameter of the third opening needs to be greater than 0.9 mm, such as 0.95 mm, 1.0 mm or 1.2 mm, so that the difference between the outer diameter of the second pipe 127 and the inner diameter of the third opening is greater than 0.1 mm.

[0081] Optionally, the first opening and the third opening are located on the same axis, the first end of the second pipe 127 passes through the third opening and the first opening in sequence, and the distance of the first end of the second pipe 127 beyond the first opening is 0.1~10mm.

[0082] The first and third openings are located on the same axis, meaning that the liquid inlet path of the tee connector 126 and the positive pressure purging path are spatially collinear, simplifying the internal flow channel design. The first end of the second pipe 127 passes through the third and first openings in sequence, placing the first end of the second pipe 127 close to the liquid outlet of the reaction tank module 11. This allows the positive pressure output from the second pipe 127 to purge the liquid before it enters the tee connector 126, slowing down the liquid flow rate and preventing blockage. It also simplifies the installation of the second pipe 127 into the tee connector 126.

[0083] Specifically, the distance by which the first end of the second pipe 127 extends beyond the first opening is 0.1~10mm, that is, Figure 6 H1 is between 0.1 and 10 mm, and can be 0.1 mm, 2 mm, 3 mm, 10 mm, etc. In this case, the port of the second pipe 127 near the liquid outlet can sway appropriately when the liquid flows. And because the first end of the second pipe 127 is close to the first opening, the reliability of bubble control can be effectively improved, and the possibility of the second pipe 127 being blocked by impurity particles mixed in the liquid when the liquid is discharged can be effectively reduced.

[0084] Optionally, the first end of the second conduit 127 is a free end or a semi-free end.

[0085] Specifically, a free end is a port that is not fixed, while a semi-free end is a port whose outer side is fixed. For example, if the first end of the second pipe 127 is a semi-free end, then the outer side of the pipe section at the first end of the second pipe 127 can be fixed to the inner wall of the tee joint 126 to form a semi-free end. When there is surrounding liquid flow, the free end will sway more than the semi-free end, but both will produce a certain degree of swaying.

[0086] By constructing a port with a free end or a semi-free end, it is possible to cause a slight sway at the first end of the second pipe 127 during liquid flow, thereby intercepting impurity particles and slowing them down.

[0087] Under normal circumstances, the liquid flow velocity in a pipeline is typically highest in the middle of the pipeline and close to zero at the pipe wall. Since the second pipeline 127 is embedded inside the tee connector 126, the first end of the second pipeline 127 is generally located in the middle of the pipeline, making it easy to encounter high-speed impurity particles in the liquid. This significantly reduces the velocity of the impurity particles, thereby improving their controllability. Consequently, they can be sucked away by the negative pressure generated by the second negative pressure drive module 15, preventing them from accumulating in the gaps or uneven connections of the first pipeline 13 or the tee connector 126, or other places where impurity particles are not desired to accumulate, thus avoiding their negative impact.

[0088] Optionally, the length of the second pipe 127 between the first end of the second pipe 127 and the sealing point of the second pipe 127 and the third opening is greater than 20 mm; and / or, the distance between the first end of the second pipe 127 and the liquid outlet of the reaction tank module 11 is less than 30 mm; and / or, the length of the first pipe 13 is less than 40 mm.

[0089] The length of the second pipe 127 between its first end and the sealing point of the third opening is greater than 20 mm, meaning the length of the second pipe 127 embedded in the tee connector 126 is greater than 20 mm. The distance between the first end of the second pipe 127 and the liquid outlet of the reaction tank module 11 is less than 30 mm, meaning... Figure 6 H2 is less than 30 mm.

[0090] Understandably, the positive pressure generated by the second positive pressure drive module 14 is delivered along the second pipeline 127 until it reaches the first port of the second pipeline 127 and comes into contact with the liquid, generating bubbles. The longer the length of the second pipeline 127 embedded in the tee connector 126, the closer the bubbles will be to the liquid outlet. The released bubbles are more likely to collide with impurity particles in the liquid, thus preventing blockage. This avoids the situation where the pipe length is too short, causing the bubbles to be released too early and unable to effectively collide with impurity particles. By setting the first port of the second pipeline 127 close to the liquid outlet of the reaction tank module 11, impurity particles flowing out of the reaction tank module 11 can be effectively and promptly blocked, reducing the possibility of impurity particles rapidly flowing and clogging the pipeline.

[0091] Meanwhile, the distance between the first end of the second pipe 127 and the outlet of the reaction tank module 11 is less than 30mm, and / or the length of the first pipe 13 is less than 40mm, which also allows the first end of the second pipe 127 to be set close to the outlet, thereby improving the controllability of bubbles.

[0092] Optionally, the inner volume of the transition cavity of the anti-blocking module 12 is less than 4 ml.

[0093] The transition cavity refers to the cavity formed between the liquid outlet of the reaction tank module 11 and the liquid inlet 122 of the anti-blocking module 12 (e.g., the liquid inlet 122 of the anti-blocking tank 121 or the first opening of the three-way connector 126).

[0094] By setting the inner volume of the transition cavity of the anti-blocking module 12 to be less than 4ml, the flow path of the liquid from the outlet of the reaction tank module 11 to the anti-blocking module 12 can be shortened, thus preventing impurity particles in the liquid from accumulating and clogging before entering the anti-blocking module 12.

[0095] In some embodiments, the inner volume of the transition cavity of the anti-blocking module 12 connected to the first reaction cell module is greater than the inner volume of the transition cavity of the anti-blocking module 12 connected to the last reaction cell module 11 that is connected to the anti-blocking module 12 during the process of the sample distribution module sequentially distributing samples to N reaction cell modules 11.

[0096] In this embodiment, because the first reaction cell module receives a high concentration of impurity particles, a larger transition cavity can provide a larger buffer space, making the liquid flow rate relatively gentle and preventing the liquid flow rate from being too high and impacting the anti-clogging module 12. The last reaction cell module 11, which is connected to the anti-clogging module 12 and distributes samples last, receives a low concentration of impurity particles, so there is no need to set up an excessively large transition cavity to buffer the liquid. Therefore, this embodiment proposes that the inner volume of the transition cavity of the anti-clogging module 12 connected to the first reaction cell module is larger than the inner volume of the transition cavity of the anti-clogging module 12 connected to the last reaction cell module 11 that distributes samples to N reaction cell modules 11 in sequence.

[0097] Optionally, the blood sample analyzer 1 also includes a swab and a swab anti-clogging module. The swab is connected to the sample dispensing module and is used to clean the sampling needle of the sample dispensing module. The swab anti-clogging module is connected to the swab. The inner volume of the transition cavity of the swab anti-clogging module is larger than the inner volume of the transition cavity of the anti-clogging module 12 connected to the first reaction cell module.

[0098] Specifically, the swab can be fitted onto the outer wall of the sampling needle to clean it. The swab anti-clogging module is used to receive the cleaning waste liquid from the swab cleaning the sampling needle. It is understood that during the cleaning of the sampling needle, the needle tip surface may have a significant amount of protein deposits, cell debris, or rubber fragments adhering to it. The cleaning fluid will wash away these impurities, forming cleaning waste liquid with a high concentration of impurities. Therefore, the inner volume of the transition cavity of the swab anti-clogging module needs to be larger than the inner volume of the transition cavity of the anti-clogging module 12 connected to the first reaction tank module, to provide a larger buffer space for the cleaning waste liquid and ensure the anti-clogging effectiveness of the swab anti-clogging module.

[0099] In some embodiments, the swab anti-clogging module is a filter type, and the filter mesh diameter in the filter type swab anti-clogging module is larger than the filter mesh diameter in the filter type anti-clogging module 12.

[0100] The anti-clogging module 12 of the first reaction tank module needs to intercept fine impurity particles to protect the downstream precision pipelines, so it usually uses a small filter screen aperture. However, the impurity particles in the sampling needle cleaning fluid are relatively large and irregular in shape. If a filter screen aperture that is too small is used, it is very easy to cause rapid clogging, resulting in poor drainage of cleaning waste fluid or even backflow. Therefore, using a filter screen with a larger aperture can ensure the interception of larger impurity particles while maintaining a high flow rate and preventing the cleaning process from being obstructed.

[0101] The above description is merely an embodiment of this application and does not limit the patent scope of this application. Any equivalent structural or procedural transformations made using the content of this application's specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of this application.

Claims

1. A blood sample analyzer, characterized in that, include: The system consists of a sample distribution module, N reaction tank modules, and M anti-clogging modules, where M is greater than or equal to 2 and N is greater than or equal to M. The sampling module sequentially distributes samples to the N reaction cell modules; The M anti-clogging modules are each connected to the outlet of a corresponding reaction tank module; The N reaction tank modules include a first reaction tank module and a second reaction tank module, and the liquid outlet of the first reaction tank module and the liquid outlet of the second reaction tank module are both connected to the corresponding anti-clogging module. The first reaction cell module is the first reaction cell module to perform sample allocation during the process of the sample allocation module sequentially allocating samples to N reaction cell modules; The second reaction pool module is any one of the N reaction pool modules, excluding the first reaction pool module; The anti-clogging module connected to the first reaction tank module is a filter type, while the anti-clogging module connected to the second reaction tank module is a non-filter type. And / or, the first reaction cell module is closest to the sampling position.

2. The blood sample analyzer according to claim 1, characterized in that, The first anti-blocking module is the anti-blocking module connected to the first reaction tank module; The second anti-blocking module is the anti-blocking module connected to the last reaction cell module that is assigned a sample during the process of the sample distribution module sequentially distributing samples to the N reaction cell modules. The first anti-blocking module is of the common cavity type, and the second anti-blocking module is of the sleeve type. And / or, the first anti-blocking module is of the type with the drain port at the bottom, and the second anti-blocking module is of the type with the drain port in the center; And / or, the first anti-blocking module is of the side-through type, and the second anti-blocking module is of the straight-through type.

3. The blood sample analyzer according to claim 1, characterized in that, The filter-type anti-clogging module includes a filter screen; The thickness of the filter screen is 6~11 mil; And / or, the number of rows per inch of the filter screen is 36±2 / in, and the number of columns per inch of the filter screen is 40±2 / in; And / or, the basis weight of the filter screen is 84.7~100 g / m²; And / or, the tensile strength of the filter screen is greater than 60 bs / in; And / or, the material of the filter is NET.

4. The blood sample analyzer according to claim 1, characterized in that, The filter-type anti-clogging module includes an anti-clogging tank and a filter screen; The blood sample analyzer further includes a first positive pressure drive module and a first negative pressure drive module. The anti-clogging tank includes an inlet, a positive pressure interface, and a negative pressure interface. The inlet is located at the top of the anti-clogging tank, and the positive pressure interface and the negative pressure interface are respectively located on the side wall of the anti-clogging tank. The inlet is connected to the outlet of the reaction tank module, the positive pressure interface is connected to the first positive pressure drive module, and the negative pressure interface is connected to the first negative pressure drive module. The filter screen is disposed inside the anti-clogging tank and located between the positive pressure interface and the negative pressure interface. And / or, the filter screen is inclinedly disposed inside the anti-clogging tank, the edge of the filter screen abuts against the inner wall of the anti-clogging tank, and the angle between the filter screen and the horizontal plane is 30°~60°.

5. The blood sample analyzer according to claim 4, characterized in that, In the height direction of the anti-clogging tank, the positive pressure port is located above the negative pressure port; And / or, the anti-clogging module further includes a filter support, which is disposed inside the anti-clogging tank and located on the side of the filter away from the liquid inlet of the anti-clogging tank.

6. The blood sample analyzer according to claim 1, characterized in that, The blood sample analyzer also includes a first pipeline, a second positive pressure drive module and a second negative pressure drive module. The non-filter type anti-clogging module includes a three-way connector and a second pipeline. The first opening of the three-way connector is connected to the liquid outlet of the reaction tank module through the first pipeline, and the second opening of the three-way connector is connected to the second negative pressure drive module. The outer diameter of the second pipe is smaller than the inner diameter of the third opening of the tee joint. The first end of the second pipe is embedded in the tee joint through the third opening, and the second pipe is sealed to the third opening. The second end of the second pipe is connected to the second positive pressure drive module. The absolute value of the negative pressure at the drive end of the second negative pressure drive module is greater than 10 kPa.

7. The blood sample analyzer according to claim 6, characterized in that, The inner diameter of the second pipeline is greater than 0.05 mm; And / or, the difference between the inner diameter of the third opening and the outer diameter of the second pipe is greater than 0.1 mm.

8. The blood sample analyzer according to claim 6, characterized in that, The first opening and the third opening are located on the same axis. The first end of the second pipe passes through the third opening and the first opening in sequence, and the distance of the first end of the second pipe beyond the first opening is 0.1~10mm. And / or, the first end of the second conduit is a free end or a semi-free end; And / or, the length of the pipe between the first end of the second pipe and the second pipe and the third opening seal is greater than 20 mm; And / or, the distance between the first end of the second pipeline and the outlet of the reaction tank module is less than 30 mm; And / or, the length of the first pipeline is less than 40 mm.

9. The blood sample analyzer according to claim 1, characterized in that, The inner volume of the transition cavity of the anti-blocking module is less than 4 ml; And / or, the inner volume of the transition cavity of the anti-blocking module connected to the first reaction cell module is greater than the inner volume of the transition cavity of the anti-blocking module connected to the last reaction cell module that is assigned a sample and connected to the anti-blocking module during the process of the sample distribution module sequentially distributing samples to N reaction cell modules.

10. The blood sample analyzer according to claim 1, characterized in that, The blood sample analyzer also includes a swab and a swab anti-clogging module. The swab is connected to the sample dispensing module and is used to clean the sampling needle of the sample dispensing module. The swab anti-clogging module is connected to the swab. Wherein, the inner cavity volume of the transition cavity of the swab anti-clogging module is greater than the inner cavity volume of the transition cavity of the anti-clogging module connected to the first reaction pool module; And / or, the swab anti-clogging module is a filter type, and the filter pore size in the filter type swab anti-clogging module is larger than the filter pore size in the filter type anti-clogging module.

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