Reagent concentration automatic detection device and reagent automatic liquid preparation equipment

Abstract

This disclosure provides an automatic reagent concentration detection device and an automatic reagent preparation device. The automatic reagent concentration detection device includes a delivery mechanism, a pipetting mechanism, and a concentration detection mechanism. The concentration detection component has a detection groove formed at its concentration detection position. The detection groove is used to hold the reagent, and the concentration detection position of the concentration detection component is used to detect the reagent concentration in the detection groove. The pipetting end of the pipetting component is used to discharge the aspirated reagent into the detection groove of the concentration detection component. The cleaning end of the reagent cleaning component is used to clean the reagent in the detection groove. The driving end of the moving drive component is fixedly connected to the fixed end of the reagent cleaning component. The moving drive component is used to drive the cleaning end of the reagent cleaning component closer to or away from the detection groove. The control end of the moving drive component is electrically connected to the control end of the first transfer component. The automatic reagent concentration detection device not only effectively improves the accuracy of reagent concentration detection but also improves the reagent detection efficiency.

Description

Technical Field

[0001] This disclosure relates to the technical field of automated reagent dispensing equipment, and in particular to an automated reagent concentration detection device and an automated reagent dispensing equipment. Background Technology

[0002] During the operation of reagent preparation equipment, the equipment injects a predetermined proportion of liquid into the reagent tube to complete the solution preparation. The concentration of the prepared liquid in the reagent tube is not only a key parameter for evaluating the accuracy of the equipment's proportioning and ensuring the quality of the final solution, but also an important input for subsequent dilution and preparation operations. If the concentration of the prepared solution deviates, it will not only directly lead to inaccurate dilution and preparation ratios, affecting the next stage of solution preparation, but also cause material waste, and in severe cases, may even cause abnormal equipment operation and safety hazards. Therefore, accurately obtaining the actual concentration of the prepared liquid in the reagent tube is an important prerequisite for ensuring the operational accuracy and stability of the reagent preparation equipment, achieving standardized solution preparation, and ensuring accurate subsequent dilution and preparation.

[0003] In the existing reagent preparation equipment workflow, the equipment injects a predetermined proportion of liquid into the reagent tube to complete the solution preparation. The industry generally uses manual methods to verify the concentration of the prepared liquid in the reagent tube. Specifically, the operator uses a pipette to draw the prepared liquid from the reagent tube and injects it into the concentration detection module to perform a concentration test, thereby obtaining the actual concentration value, which provides a reference for subsequent reagent dilution and preparation. After the test is completed, the detection module is manually wiped, and then the next round of testing is carried out.

[0004] However, the manual testing operation mode has the following obvious drawbacks: On the one hand, the entire process of manual sampling, testing, and wiping is cumbersome and time-consuming, which cannot match the continuous and efficient operation rhythm of reagent preparation equipment, resulting in low overall testing efficiency and severely restricting the overall operational capacity of the equipment. On the other hand, the cleaning work after testing relies on manual wiping, and the wiping range and force are difficult to standardize. This can easily lead to trace amounts of reagents and impurities remaining in the testing module, causing cross-contamination of samples, reducing the accuracy of concentration detection, and affecting the accuracy of equipment ratio calibration. It cannot meet the current needs of high-precision, automated intelligent reagent preparation equipment. Summary of the Invention

[0005] The purpose of this disclosure is to overcome the shortcomings of the prior art and provide an automatic reagent concentration detection device and an automatic reagent dispensing equipment that can not only effectively reduce the possibility of reagent contamination during concentration detection, but also improve reagent detection efficiency.

[0006] The purpose of this disclosure is achieved through the following technical solution: An automatic reagent concentration detection device includes a delivery mechanism, a pipetting mechanism, and a concentration detection mechanism; The conveying end of the conveying mechanism is used to convey reagent tubes. The pipetting mechanism includes a first transfer component and a pipetting component. The transfer end of the first transfer component is fixedly connected to the pipetting component, and the pipetting end of the pipetting component is used to aspirate a portion of the reagent located in the reagent tube of the delivery mechanism. The concentration detection mechanism includes a concentration detection component, a reagent cleaning component, and a moving drive component. The concentration detection component has a detection groove formed at its concentration detection position. The detection groove is used to hold reagents, and the concentration detection position of the concentration detection component is used to detect the concentration of the reagents in the detection groove. The pipetting end of the pipetting component is used to discharge the aspirated reagents into the detection groove of the concentration detection component. The cleaning end of the reagent cleaning component is used to clean the reagents in the detection groove. The driving end of the moving drive component is fixedly connected to the fixed end of the reagent cleaning component. The moving drive component is used to drive the cleaning end of the reagent cleaning component to move closer to or away from the detection groove. The control end of the moving drive component is electrically connected to the control end of the first transfer component.

[0007] In one embodiment, the concentration detection component includes a concentration detector and a sealing cover. The concentration detection position of the concentration detection component is located on the concentration detector, the detection groove is formed on the top end face of the concentration detector, and the sealing cover is disposed on the concentration detector and is used to cover the opening of the detection groove.

[0008] In one embodiment, the hinged end of the sealing cover is hinged to the concentration detector, the covering end of the sealing cover is disposed opposite to the detection groove, and the covering end of the sealing cover is used to cover the opening of the detection groove.

[0009] In one embodiment, the sealing cover includes a covering part, a connecting part, and a hinge part fixed in sequence. The hinge end of the sealing cover is located at the hinge part, and the covering end of the sealing cover is located at the covering part. A sealing ring is provided on one side of the covering part facing the detection groove. The sealing ring is used to surround the detection groove when the covering part is placed over the opening of the detection groove and to press against the top end face of the concentration detector. The hinge part is hinged to the concentration detector.

[0010] In one embodiment, the concentration detection component further includes a flip-top drive, wherein the flip-top drive end of the flip-top drive is fixedly connected to the cover portion, and the flip-top drive end of the flip-top drive is disposed away from the sealing ring, and the flip-top drive end of the flip-top drive is used to drive the cover portion to perform a closing or opening operation.

[0011] In one embodiment, the automatic reagent concentration detection device further includes a frame, the top of which has a bearing mounting surface. The conveying mechanism and the pipetting mechanism are both mounted on the bearing mounting surface. The reagent cleaning assembly includes a fixed base and a cleaning component. The concentration detector is mounted on the bearing mounting surface. The fixed end of the cleaning component is fixed to the fixed base. The fixed base is slidably assembled to the frame. The fixed end of the moving drive assembly is fixedly connected to the frame. The driving end of the moving drive assembly is fixedly connected to the fixed base. The driving end of the moving drive assembly is used to drive the fixed base to slide relative to the frame. The cleaning end of the cleaning component is disposed opposite to the opening of the detection tank. The cleaning end of the cleaning component is used to clean the reagent in the detection tank.

[0012] In one embodiment, the cleaning component includes a liquid-absorbing belt, an unwinding machine, and a winding machine. Both the unwinding machine and the winding machine are fixed to the fixed base, and a transmission path is formed between them. One end of the liquid-absorbing belt is wound around the winding end of the unwinding machine, and the unwinding machine releases the cleaned liquid-absorbing belt. The other end of the liquid-absorbing belt is wound around the winding end of the winding machine, and the winding machine collects the liquid-absorbing belt after liquid absorption. The transmission path of the liquid-absorbing belt sequentially passes through the winding end of the unwinding machine, the concentration detection position of the concentration detection component, and the winding end of the winding machine. The liquid-absorbing belt located at the concentration detection position is used to absorb the reagent in the detection tank. A supporting flange protrudes from one side of the sealing cover facing the detection tank. The supporting flange is correspondingly positioned to the detection tank, and the supporting flange is used to push the liquid-absorbing belt to abut against the inner wall of the detection tank when the sealing cover is closed on the opening of the detection tank.

[0013] In one embodiment, the reagent cleaning assembly further includes a driving cylinder and a holding member. The fixed end of the driving cylinder is fixed to the frame, and the driving end of the driving cylinder is fixedly connected to the holding member. The driving cylinder is used to drive the holding member to the opening of the detection tank. The holding member is provided with a supporting flange, which is correspondingly arranged with the detection tank. The holding member is used to push the liquid absorption belt to abut against the inner wall of the detection tank when it moves to the opening of the detection tank.

[0014] In one embodiment, the reagent cleaning assembly further includes a suction belt detector. The fixed end of the suction belt detector is mounted and fixed to the fixed base. The detection end of the suction belt detector is arranged facing the transmission path and spaced apart from the cleaning component. The suction belt detector is used to detect whether there is a suction belt in the transmission path. The control end of the suction belt detector is electrically connected to the control ends of the conveying mechanism, the pipetting mechanism, and the cleaning component, respectively.

[0015] An automatic reagent preparation device includes an automatic reagent concentration detection device according to any of the above embodiments.

[0016] Compared with the prior art, this disclosure has at least the following advantages: 1. In the above-mentioned automatic reagent concentration detection device, the transfer end of the first transfer component is fixedly connected to the pipetting component, and the pipetting end of the pipetting component is used to aspirate a portion of the reagent in the reagent tube of the delivery mechanism; the concentration detection mechanism includes a concentration detection component, a reagent cleaning component, and a moving drive component. The concentration detection position of the concentration detection component forms a detection groove, which is used to contain the reagent. The concentration detection position of the concentration detection component is used to detect the reagent concentration in the detection groove. The pipetting end of the pipetting component is used to discharge the aspirated reagent into the detection groove of the concentration detection component. During the operation of the automatic reagent concentration detection device, the first transfer component drives the pipetting component to move to the delivery end of the delivery mechanism. The pipetting end of the pipetting component aspirates the reagent in the reagent tube and transfers it to the detection groove of the concentration detection component through the first transfer component. The concentration detection component can detect the concentration of the reagent in the detection groove to determine whether the reagent concentration in the reagent tube meets the requirements. Compared with manual operation, the automatic reagent concentration detection device of this disclosure can complete automatic sampling, pipetting, and concentration detection, which greatly improves the automation level of the automatic reagent concentration detection device, thereby greatly improving the efficiency and convenience of reagent concentration detection.

[0017] 2. Since the cleaning end of the reagent cleaning component is used to clean the reagent in the detection tank, the driving end of the moving drive component is fixedly connected to the fixed end of the reagent cleaning component. The moving drive component is used to drive the cleaning end of the reagent cleaning component to move closer to or away from the detection tank. The control end of the moving drive component is electrically connected to the control end of the first transfer component. After the concentration detection position of the concentration detection component completes the current round of concentration detection, the control end of the first transfer component will transmit a cleaning signal to the control end of the moving drive component. After receiving the cleaning signal, the moving drive component will drive the cleaning end of the reagent cleaning component to move closer to and abut against the inner wall of the detection tank to clean the reagent in the detection tank and prevent the reagent residue on the inner wall of the detection tank from contaminating the next round of detection. The reagents in the tank are cleaned to prevent cross-contamination. After the cleaning operation is completed, the control end of the first transfer component will transmit a stop signal to the control end of the moving drive component. Upon receiving the stop signal, the moving drive component will drive the cleaning end of the reagent cleaning component away from the concentration detection position of the concentration detection component. This not only avoids interference between the pipetting mechanism and the reagent cleaning component, but also prevents the reagent cleaning component from affecting the operation of the concentration detection component. This allows the automatic reagent concentration detection device to also automatically clean the concentration detection position, further improving the automation level of the automatic reagent concentration detection device, thereby greatly improving the concentration detection accuracy and efficiency of the reagents. Attached Figure Description

[0018] To more clearly illustrate the technical solutions of the embodiments of this disclosure, the accompanying drawings used in the embodiments will be briefly described below. It should be understood that the following drawings only show some embodiments of this disclosure and should not be regarded as a limitation of the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the structure of an automatic reagent concentration detection device according to an embodiment; Figure 2 for Figure 1 A partially enlarged schematic diagram of the automatic reagent concentration detection device shown; Figure 3 for Figure 1 A partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 4 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 5 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 6 for Figure 1Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 7 for Figure 6 A partially enlarged schematic diagram of the automatic reagent concentration detection device shown; Figure 8 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 9 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 10 for Figure 9 A partially enlarged schematic diagram of the automatic reagent concentration detection device shown; Figure 11 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 12 for Figure 1 Another partial structural schematic diagram of the automatic reagent concentration detection device shown; Figure 13 This is a schematic diagram of the structural model of an automatic reagent concentration detection device.

[0020] Reference numerals in the figures: Automatic reagent concentration detection device 10; Conveying mechanism 100; Reagent tube conveyor belt 110; Second transfer assembly 120; Pipetting mechanism 200; First transfer assembly 210; Pipetting assembly 220; Concentration detection mechanism 300; Concentration detection assembly 310; Detection tank 311; Concentration detector 312; Step structure 3121; Sealing cover 313; Covering part 3131; Connecting part 3132; Hinge part 3133; Sealing ring 313 4; Flip-top drive component 314; Reagent cleaning assembly 320; Fixed base 321; Guide card receiving slot 3211; Cleaning component 322; Liquid suction belt 3221; Unwinder 3222; Rewinder 3223; Drive cylinder 323; Holding component 324; Liquid suction belt detector 325; Moving drive assembly 330; Frame 400; Bearing mounting surface 410; Guide card receiving flange 420; Liquid transfer position 430; Liquid pipette tip replacement mechanism 500; Barcode scanner 600. Detailed Implementation

[0021] To facilitate understanding of this disclosure, a more complete description will be given below with reference to the accompanying drawings, which illustrate preferred embodiments of the present disclosure. However, this disclosure can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and complete understanding of the disclosure.

[0022] It should be noted that when an element is referred to as being "fixed to" another element, it can be directly attached to the other element or there may be an intervening element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or there may be an intervening element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only possible implementation.

[0023] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of this disclosure. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0024] To better understand the technical solutions and beneficial effects of this disclosure, the following detailed description is provided in conjunction with specific embodiments: like Figures 1 to 13 As shown, an embodiment of an automatic reagent concentration detection device 10 includes a conveying mechanism 100, a pipetting mechanism 200, and a concentration detection mechanism 300. The conveying end of the conveying mechanism 100 is used to convey the reagent tube. The pipetting mechanism 200 includes a first transfer component 210 and a pipetting component 220. The transfer end of the first transfer component 210 is fixedly connected to the pipetting component 220, and the pipetting end of the pipetting component 220 is used to aspirate a portion of the reagent located in the reagent tube of the conveying mechanism 100. The concentration detection mechanism 300 includes a concentration detection component 310, a reagent cleaning component 320, and a movement drive component 330. A detection groove 3 is formed at the concentration detection position of the concentration detection component 310. 11. The detection tank 311 is used to contain reagents. The concentration detection position of the concentration detection component 310 is used to detect the concentration of the reagent in the detection tank 311. The pipetting end of the pipetting component 220 is used to discharge the aspirated reagent into the detection tank 311 of the concentration detection component 310. The cleaning end of the reagent cleaning component 320 is used to clean the reagent in the detection tank 311. The driving end of the moving drive component 330 is fixedly connected to the fixed end of the reagent cleaning component 320. The moving drive component 330 is used to drive the cleaning end of the reagent cleaning component 320 to move closer to or away from the detection tank 311. The control end of the moving drive component 330 is electrically connected to the control end of the first transfer component 210.

[0025] The aforementioned automatic reagent concentration detection device 10, since the transfer end of the first transfer component 210 is fixedly connected to the pipetting component 220, and the pipetting end of the pipetting component 220 is used to aspirate a portion of the reagent in the reagent tube of the delivery mechanism 100; the concentration detection mechanism 300 includes a concentration detection component 310, a reagent cleaning component 320, and a movement drive component 330, the concentration detection position of the concentration detection component 310 forms a detection groove 311, the detection groove 311 is used to contain the reagent, the concentration detection position of the concentration detection component 310 is used to detect the reagent concentration in the detection groove 311, and the pipetting end of the pipetting component 220 is used to discharge the aspirated reagent into the detection groove 311 of the concentration detection component 310, in the automatic reagent concentration detection device 10 During operation, the first transfer component 210 drives the pipetting component 220 to the delivery end of the delivery mechanism 100. The pipetting end of the pipetting component 220 draws the reagent from the reagent tube and transfers it through the first transfer component 210 to the detection tank 311 of the concentration detection component 310. The concentration detection component 310 can detect the concentration of the reagent in the detection tank 311 to determine whether the concentration of the reagent in the reagent tube meets the requirements. Compared with manual operation, the automatic reagent concentration detection device 10 of this disclosure can complete automatic sampling, pipetting and concentration detection, which greatly improves the automation level of the automatic reagent concentration detection device 10, thereby greatly improving the efficiency and convenience of reagent concentration detection.

[0026] Furthermore, since the cleaning end of the reagent cleaning component 320 is used to clean the reagent in the detection tank 311, the driving end of the moving drive component 330 is fixedly connected to the fixed end of the reagent cleaning component 320. The moving drive component 330 is used to drive the cleaning end of the reagent cleaning component 320 closer to or further away from the detection tank 311. The control end of the moving drive component 330 is electrically connected to the control end of the first transfer component 210. After the concentration detection position of the concentration detection component 310 completes the current round of concentration detection, the control end of the first transfer component 210 will transmit a cleaning signal to the control end of the moving drive component 330. After receiving the cleaning signal, the moving drive component 330 will drive the cleaning end of the reagent cleaning component 320 to approach and abut against the inner wall of the detection tank 311 to clean the reagent in the detection tank 311 and avoid contamination by residual reagent on the inner wall of the detection tank 311. The next batch of reagents enters the detection tank 311 to prevent cross-contamination. After the cleaning operation is completed, the control terminal of the first transfer component 210 will transmit a stop signal to the control terminal of the motion drive component 330. After receiving the stop signal, the motion drive component 330 will drive the cleaning end of the reagent cleaning component 320 away from the concentration detection position of the concentration detection component 310. This not only avoids interference between the pipetting mechanism 200 and the reagent cleaning component 320, but also prevents the reagent cleaning component 320 from affecting the operation of the concentration detection component 310. This allows the automatic reagent concentration detection device 10 to also automatically clean the concentration detection position, further improving the automation level of the automatic reagent concentration detection device 10, thereby greatly improving the concentration detection accuracy and efficiency of the reagent.

[0027] It should be noted that this disclosure only protects the positional relationship between the mobile drive component 330 and the first transfer component 210. The signal transmission function between the mobile drive component 330 and the first transfer component 210 is prior art and will not be described in detail here.

[0028] It should be noted that the pipetting assembly 220 only transfers a small amount of reagent in the reagent tube, and the reagent tube is in an open state.

[0029] like Figures 1 to 10 As shown, in one embodiment, the concentration detection component 310 includes a concentration detector 312 and a sealing cover 313. The concentration detection position of the concentration detection component 310 is located on the concentration detector 312. The detection groove 311 is formed on the top end face of the concentration detector 312. The sealing cover 313 is disposed on the concentration detector 312 and is used to cover the groove opening of the detection groove 311. This allows the sealing cover 313 to effectively reduce the risk of external dust or debris entering the detection groove 311 from the groove opening, greatly reducing the possibility of reagent contamination in the detection groove 311, and thus greatly improving the concentration detection accuracy of the reagent.

[0030] It should be noted that this disclosure only protects the positional and connection relationships of the concentration detector 312. The structure and principle of the concentration detector 312 for detecting reagent concentration are existing technologies and will not be elaborated here.

[0031] like Figures 9 to 10 As shown, in one embodiment, the hinged end of the sealing cover 313 is hinged to the concentration detector 312, and the covering end of the sealing cover 313 is disposed opposite to the detection groove 311. The covering end of the sealing cover 313 is used to cover the opening of the detection groove 311, so that during the use of the concentration detector 312, the covering end of the sealing cover 313 can be rotated relative to the concentration detector 312 to realize the opening and closing operation of the detection groove 311, which greatly reduces the difficulty of opening and closing the sealing cover 313, and thus greatly improves the ease of use of the automatic reagent concentration detection device 10.

[0032] like Figures 9 to 10 As shown, in one embodiment, the sealing cover 313 includes a covering portion 3131, a connecting portion 3132, and a hinge portion 3133, which are fixed in sequence. The hinge end of the sealing cover 313 is located at the hinge portion 3133, and the covering end of the sealing cover 313 is located at the covering portion 3131. A sealing ring 3134 is provided on one side of the covering portion 3131 facing the detection groove 311. The sealing ring 3134 is used to surround the detection groove 311 when the covering portion 3131 covers the opening of the detection groove 311 and to press against the top end face of the concentration detector 312. The hinge portion 3133 is hinged to the concentration detector 312 so that the covering portion... 3131 is fixed to the hinge part 3133 via the connecting part 3132, so that the covering part 3131 can rotate relative to the concentration detector 312 with the hinge part 3133 as the rotation center. When the sealing cover plate 313 is closed on the groove of the detection groove 311, the covering part 3131 of the sealing cover plate 313 can be sealed in the gap between the top end face of the concentration detector 312 by the sealing ring 3134, effectively preventing external dust or debris from entering the detection groove 311 through the gap between the covering part 3131 and the concentration detector 312, avoiding contamination of the reagent in the detection groove 311, and further improving the concentration detection accuracy of the reagent.

[0033] It should be noted that the hinge structure between the hinge part 3133 and the concentration detector 312 is existing technology and will not be described in detail here.

[0034] like Figures 9 to 10 As shown, in this embodiment, the covering part 3131, the connecting part 3132 and the hinge part 3133 are integrally formed to improve the structural compactness of the sealing cover plate 313.

[0035] like Figures 4 to 12As shown, in one embodiment, the concentration detection component 310 further includes a flip-top drive member 314. The flip-top drive end of the flip-top drive member 314 is fixedly connected to the cover portion 3131, and the flip-top drive end of the flip-top drive member 314 is disposed away from the sealing ring 3134. The flip-top drive end of the flip-top drive member 314 is used to drive the cover portion 3131 to perform a closing or opening operation, so that the flip-top drive end of the flip-top drive member 314 can drive the cover portion 3131 to rotate relative to the concentration detector 312 with the hinge portion 3133 as the rotation center. This enables the flip-top drive member 314 to realize the automatic opening or closing operation of the cover portion 3131, further improving the automation level of the automatic reagent concentration detection device 10, and thus greatly improving the ease of use of the automatic reagent concentration detection device 10.

[0036] like Figures 1 to 12 As shown, in one embodiment, the automatic reagent concentration detection device 10 further includes a frame 400, with a bearing mounting surface 410 formed at the top of the frame 400. The conveying mechanism 100 and the pipetting mechanism 200 are both mounted on the bearing mounting surface 410. The reagent cleaning assembly 320 includes a fixed base 321 and a cleaning component 322. The concentration detector 312 is mounted on the bearing mounting surface 410. The fixed end of the cleaning component 322 is fixed to the fixed base 321. The fixed base 321 is slidably assembled to the frame 400. The fixed end of the moving drive assembly 330 is fixedly connected to the frame 400, and the driving end of the moving drive assembly 330 is fixed to the fixed base 400. The base 321 is fixedly connected, and the driving end of the moving drive assembly 330 is used to drive the fixed base 321 to slide relative to the frame 400. The cleaning end of the cleaning component 322 is arranged opposite to the opening of the detection tank 311. The cleaning end of the cleaning component 322 is used to clean the reagent in the detection tank 311, so that the driving end of the moving drive assembly 330 can drive the fixed base 321 to slide relative to the frame 400, so that the fixed base 321 can drive the cleaning component 322 to move relative to the concentration detector 312, thereby enabling the driving end of the moving drive assembly 330 to control the cleaning end of the cleaning component 322 to move closer to or further away from the detection tank 311.

[0037] In this embodiment, the moving drive component 330 is a drive cylinder or a drive motor.

[0038] like Figures 1 to 3As shown, in this embodiment, the frame 400 is provided with a pipette tip replacement mechanism 500. The pipette tip replacement mechanism 500 has a pipette tip replacement position, which is used to replace the pipette tip at the pipetting end of the pipetting assembly 220. After the pipetting assembly 220 completes the pipetting operation, the first transfer assembly 210 will drive the pipetting end of the pipetting assembly 220 into the pipette tip replacement position to perform the pipette tip replacement operation, so that the pipette tip replacement mechanism 500 can replace the pipetting end of the pipetting assembly 220 with a clean pipette tip, avoiding the problem of reagent cross-contamination caused by repeated use of pipette tips, thereby greatly improving the concentration detection accuracy of reagents.

[0039] It should be noted that the pipetting function of the pipetting assembly 220 disclosed herein, as well as the function of the pipetting tip replacement mechanism for automatically replacing the pipetting tip of the pipetting assembly 220, are all prior art, such as the pipetting assembly 220 disclosed in prior art patent CN114261939A, which will not be described in detail here.

[0040] like Figures 4 to 6As shown, in one embodiment, the cleaning component 322 includes a liquid-absorbing belt 3221, an unwinder 3222, and a rewinder 3223. Both the unwinder 3222 and the rewinder 3223 are fixedly mounted on a fixed base 321, and a transmission path is formed between them. One end of the liquid-absorbing belt 3221 is wound around the winding end of the unwinder 3222. The unwinder 3222 is used to release the clean liquid-absorbing belt 3221. The other end of 221 is wound around the winding end of the winding machine 3223. The winding machine 3223 is used to collect the liquid absorption tape 3221 after liquid absorption is completed. The transmission path of the liquid absorption tape 3221 passes sequentially through the winding end of the unwinding machine 3222, the concentration detection position of the concentration detection component 310, and the winding end of the winding machine 3223. The liquid absorption tape 3221 located at the concentration detection position is used to absorb the reagent in the liquid detection tank 311; and the top end face of the concentration detector 312 also forms The device has a stepped structure 3121, with a detection groove 311 formed at the top of the stepped structure 3121. The absorbent belt 3221, located at the concentration detection position, is attached to the top of the stepped structure 3121. When it is necessary to remove the reagent in the detection groove 311, firstly, the driving end of the moving drive assembly 330 drives the absorbent belt 3221 to move to the top of the stepped structure 3121 so that the absorbent belt 3221 can effectively adsorb the reagent in the detection groove 311. Then, the unwinding machine 3222 and the winding machine 3223 work simultaneously so that the unwinding machine 3222 can release the clean absorbent belt 3221, and the absorbent belt 3221, after absorption, can be wound and stored at the winding end of the winding machine 3223, so that the absorbent belt 3221 can move along the transmission path, thereby realizing the absorption and cleaning operation of the reagent in the detection groove 311, ensuring that the reagent in the detection groove 311 can be cleaned, thus greatly improving the concentration detection accuracy of the reagent. Furthermore, the unwinding machine 3222 and the winding machine 3223 have the same winding speed to ensure that the tension of the liquid absorption belt 3221 located at the concentration detection position remains stable, so that the cleaning component 322 can more effectively clean the reagent in the detection tank 311.

[0041] It should be noted that the winding and unwinding functions of the unwinder 3222 and the winding machine 3223 are existing technologies. This disclosure only protects the positional relationship and connection relationship between the unwinder 3222 and the winding machine 3223.

[0042] like Figures 4 to 11As shown, in one embodiment, the reagent cleaning assembly 320 further includes a driving cylinder 323 and a holding member 324. The fixed end of the driving cylinder 323 is fixed to the frame 400, and the driving end of the driving cylinder 323 is fixedly connected to the holding member 324. The driving cylinder 323 is used to drive the holding member 324 to the opening of the detection tank 311. The holding member 324 is provided with a supporting flange, which is correspondingly arranged with the detection tank 311. When the holding member 324 moves to the opening of the detection tank 311, it pushes the suction belt 3221 to abut against the inner wall of the detection tank 311, so that the suction belt 3221 can effectively clean the reagent on the inner wall of the detection tank 311, ensuring that the reagent in the detection tank 311 can be cleaned, and further improving the concentration detection accuracy of the reagent.

[0043] It is understood that the concentration detector 312 disclosed herein uses spectrophotometric detection to detect reagent concentration. The part where the detection groove 311 is opened has a mirror structure. If the supporting flange exerts too much pressure on the inner wall of the detection groove 311 during cleaning, it is easy to scratch the mirror structure, resulting in a decrease in the accuracy of reagent concentration detection.

[0044] like Figure 11 As shown, in one embodiment, the support flange is an elastic support flange, so that the support flange has elastic properties, which allows the support flange to buffer the extrusion force dispersed between the inner walls of the detection groove 311 by its own elastic properties, reducing the risk of scratches on the mirror structure, thereby improving the concentration detection accuracy of the reagent.

[0045] like Figures 1 to 12As shown, in one embodiment, the control terminal of the flip-top drive 314 is electrically connected to the control terminals of the first transfer assembly 210, the movement drive assembly 330, and the concentration detector 312, respectively. When the pipetting mechanism 200 needs to perform a pipetting operation, the control terminal of the first transfer assembly 210 transmits an opening signal to the control terminal of the flip-top drive 314. Upon receiving the opening signal, the flip-top drive 314 drives the sealing cover 313 to perform the opening operation. When the concentration detector 312 needs to perform concentration detection... During operation, the control terminal of the concentration detector 312 transmits a closing signal to the control terminal of the flip-top drive 314. Upon receiving the closing signal, the flip-top drive 314 drives the sealing cover 313 to close the cover. When the detection tank 311 of the concentration detector 312 needs to be cleaned by suction, the control terminal of the movement drive assembly 330 transmits an opening signal to the control terminal of the flip-top drive 314. Upon receiving the opening signal, the flip-top drive 314 drives the sealing cover 313 to open the cover, allowing the suction belt 313 to open. 221 can smoothly move to the top of the opening of the detection tank 311. Simultaneously, when the moving drive assembly 330 drives the suction belt 3221 to the opening of the detection tank 311, the drive end of the drive cylinder 323 drives the holding member 324 to move to the opening of the detection tank 311, allowing the support flange to push the suction belt 3221 against the inner wall of the detection tank 311, enabling the suction belt 3221 to effectively adsorb the reagent in the detection tank 311. After the concentration detector 312 completes the reagent cleaning, the drive cylinder 323... The drive end first drives the holding member 324 away from the detection tank 311, and then the moving drive assembly 330 drives the aspirating belt 3221 away from the detection tank 311; and the pipetting operation of the pipetting assembly 220 and the cleaning operation of the reagent cleaning assembly 320 are performed alternately (one cleaning - one pipetting sampling - one detection - one cleaning), avoiding mutual interference between the two components, further improving the automation level of the automatic reagent concentration detection device 10, and thus greatly improving the ease of use of the automatic reagent concentration detection device 10.

[0046] It should be noted that the flip-top function of the flip-top drive unit 314 is existing technology, and the signal transmission functions of the flip-top drive unit 314 with the first transfer component 210, the movement drive component 330 and the concentration detector 312 are also existing technologies, which will not be elaborated here.

[0047] like Figures 5 to 8As shown, in one embodiment, a fixed base 321 is disposed on a side of the frame 400 away from the bearing mounting surface 410. The fixed base 321 has a guide slot 3211, and the frame 400 has a guide flange 420 adapted to the guide slot 3211. The extending direction of the guide flange 420 is parallel to the bearing mounting surface 410. The fixed base 321 is locked onto the guide flange 420 by the guide slot 3211. The guide flange 420 slides against the inner wall of the guide slot 3211. This not only allows the fixed base 321 to be securely locked onto the frame 400 by the mutual cooperation between the guide slot 3211 and the guide flange 420, but also allows the fixed base 321 to slide relative to the frame 400.

[0048] like Figures 5 to 8 As shown, in one embodiment, the reagent cleaning assembly 320 further includes a suction belt detector 325. The fixed end of the suction belt detector 325 is fixedly mounted on the fixed base 321. The detection end of the suction belt detector 325 is arranged facing the transmission path and spaced apart from the cleaning component 322. The suction belt detector 325 is used to detect whether the suction belt 3221 exists on the transmission path. The control end of the suction belt detector 325 is electrically connected to the control ends of the delivery mechanism 100, the pipetting mechanism 200, and the cleaning component 322, respectively. When the suction belt detector 325 detects a suction belt 3221 on the transmission path... Once the aspiration tape 3221 is depleted, the control terminal of the aspiration tape detector 325 will transmit a stop signal to the control terminals of the conveying mechanism 100, the pipetting mechanism 200, and the cleaning component 322, so that the conveying mechanism 100, the pipetting mechanism 200, and the cleaning component 322 can stop working. This not only avoids the abnormal development of subsequent detection work caused by the depletion of the aspiration tape 3221, but also makes it convenient for staff to replace the aspiration tape 3221, thereby greatly improving the ease of use of the automatic reagent concentration detection device 10 and the accuracy of reagent concentration detection.

[0049] like Figures 1 to 2As shown, in one embodiment, the conveying mechanism 100 includes a reagent tube conveyor belt 110 and a second transfer assembly 120. The reagent tube conveyor belt 110 is used to convey reagent tubes to the next process. The frame 400 has a transfer position 430, and the transfer position 430 has a receiving and positioning groove for receiving and positioning reagent tubes. The reagent tube conveyor belt 110 and the fixed end of the second transfer assembly 120 are installed and fixed to the frame 400. The transfer end of the second transfer assembly 120 is used to convey the reagent tubes on the reagent tube conveyor belt 110 to the receiving and positioning groove. The transfer end of the transfer assembly 220 is used to transfer the reagent tubes located at the transfer position 430 to the receiving and positioning groove. The reagent in the reagent tube on the liquid transfer position 430 is transferred to the detection tank 311 of the concentration detector 312. After the reagent tube on the liquid transfer position 430 has completed the sampling operation, the second transfer component 120 will transfer the reagent tube on the liquid transfer position 430 to the reagent tube conveyor belt 110, so that the reagent tube conveyor belt 110 is used to transport the reagent tube to the next process. This not only prevents the reagent from dripping onto the reagent tube conveyor belt 110 during the sampling process, but also positions the reagent tube by accommodating the positioning groove, preventing the reagent tube from shaking or even tipping over during the sampling process, thereby greatly improving the stability of the automatic reagent concentration detection device 10.

[0050] like Figures 1 to 2 As shown, in one embodiment, the conveying mechanism 100 further includes a barcode scanner 600, which is mounted and fixed on the frame 400. The second transfer component 120 is used to pass through the scanning end of the barcode scanner 600 when transferring the reagent tube. The scanning end of the barcode scanner 600 is used to scan the code on the reagent tube. The control end of the barcode scanner 600 is electrically connected to the control end of the concentration detector 312. During the process of transferring the reagent tube from the reagent tube conveyor belt 110 to the liquid transfer position 430, the reagent tube will pass through the scanning end of the barcode scanner 600. At this time, the scanning end of the barcode scanner 600 will scan the code on the reagent tube so that the concentration detector 312 can pair and record the reagent concentration detection result with the corresponding reagent tube one by one, realize the binding and storage of single-tube reagent detection data, and facilitate the subsequent liquid preparation work.

[0051] It should be noted that both the first transfer component 210 and the second transfer component 120 are transfer robotic arms, which will not be described in detail here.

[0052] This disclosure also provides an automatic reagent preparation device, including the automatic reagent concentration detection device 10 of any of the above embodiments.

[0053] Compared with the prior art, this disclosure has at least the following advantages: 1. In the aforementioned automatic reagent preparation equipment, the transfer end of the first transfer component 210 is fixedly connected to the pipetting component 220, and the pipetting end of the pipetting component 220 is used to aspirate a portion of the reagent in the reagent tube of the delivery mechanism 100; the concentration detection mechanism 300 includes a concentration detection component 310, a reagent cleaning component 320, and a movement drive component 330. The concentration detection position of the concentration detection component 310 forms a detection groove 311, which is used to contain the reagent. The concentration detection position of the concentration detection component 310 is used to detect the reagent concentration in the detection groove 311. The pipetting end of the pipetting component 220 is used to discharge the aspirated reagent into the detection groove 311 of the concentration detection component 310. In the automatic reagent concentration detection device 10... During operation, the first transfer component 210 drives the pipetting component 220 to the delivery end of the delivery mechanism 100. The pipetting end of the pipetting component 220 draws the reagent from the reagent tube and transfers it through the first transfer component 210 to the detection tank 311 of the concentration detection component 310. The concentration detection component 310 can detect the concentration of the reagent in the detection tank 311 to determine whether the concentration of the reagent in the reagent tube meets the requirements. Compared with manual operation, the automatic reagent concentration detection device 10 of this disclosure can complete automatic sampling, pipetting and concentration detection, which greatly improves the automation level of the automatic reagent concentration detection device 10, thereby greatly improving the efficiency and convenience of reagent concentration detection.

[0054] 2. Since the cleaning end of the reagent cleaning component 320 is used to clean the reagent in the detection tank 311, the driving end of the moving drive component 330 is fixedly connected to the fixed end of the reagent cleaning component 320. The moving drive component 330 is used to drive the cleaning end of the reagent cleaning component 320 to move closer to or away from the detection tank 311. The control end of the moving drive component 330 is electrically connected to the control end of the first transfer component 210. After the concentration detection position of the concentration detection component 310 completes the current round of concentration detection, the control end of the first transfer component 210 will transmit a cleaning signal to the control end of the moving drive component 330. After receiving the cleaning signal, the moving drive component 330 will drive the cleaning end of the reagent cleaning component 320 to move closer to and abut against the inner wall of the detection tank 311 to clean the reagent in the detection tank 311 and avoid contamination by residual reagent on the inner wall of the detection tank 311. The next batch of reagents enters the detection tank 311 to prevent cross-contamination. After the cleaning operation is completed, the control terminal of the first transfer component 210 will transmit a stop signal to the control terminal of the motion drive component 330. After receiving the stop signal, the motion drive component 330 will drive the cleaning end of the reagent cleaning component 320 away from the concentration detection position of the concentration detection component 310. This not only avoids interference between the pipetting mechanism 200 and the reagent cleaning component 320, but also prevents the reagent cleaning component 320 from affecting the operation of the concentration detection component 310. This allows the automatic reagent concentration detection device 10 to also automatically clean the concentration detection position, further improving the automation level of the automatic reagent concentration detection device 10, thereby greatly improving the concentration detection accuracy and efficiency of the reagent.

[0055] The embodiments described above are merely illustrative of several implementations of this disclosure, and while the descriptions are specific and detailed, they should not be construed as limiting the scope of the disclosed patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this disclosure, and these all fall within the protection scope of this disclosure. Therefore, the protection scope of this patent should be determined by the appended claims.

Claims

1. An automatic reagent concentration detection device, characterized in that, Includes a delivery mechanism, a pipetting mechanism, and a concentration detection mechanism; The conveying end of the conveying mechanism is used to convey reagent tubes. The pipetting mechanism includes a first transfer component and a pipetting component. The transfer end of the first transfer component is fixedly connected to the pipetting component, and the pipetting end of the pipetting component is used to aspirate a portion of the reagent located in the reagent tube of the delivery mechanism. The concentration detection mechanism includes a concentration detection component, a reagent cleaning component, and a moving drive component. The concentration detection component has a detection groove formed at its concentration detection position. The detection groove is used to hold reagents, and the concentration detection position of the concentration detection component is used to detect the concentration of the reagents in the detection groove. The pipetting end of the pipetting component is used to discharge the aspirated reagents into the detection groove of the concentration detection component. The cleaning end of the reagent cleaning component is used to clean the reagents in the detection groove. The driving end of the moving drive component is fixedly connected to the fixed end of the reagent cleaning component. The moving drive component is used to drive the cleaning end of the reagent cleaning component to move closer to or away from the detection groove. The control end of the moving drive component is electrically connected to the control end of the first transfer component.

2. The automatic reagent concentration detection device according to claim 1, characterized in that, The concentration detection component includes a concentration detector and a sealing cover. The concentration detection position of the concentration detection component is located on the concentration detector. The detection groove is formed on the top end face of the concentration detector. The sealing cover is disposed on the concentration detector and is used to cover the opening of the detection groove.

3. The automatic reagent concentration detection device according to claim 2, characterized in that, The hinged end of the sealing cover is hinged to the concentration detector, and the covering end of the sealing cover is disposed opposite to the detection groove. The covering end of the sealing cover is used to cover the opening of the detection groove.

4. The automatic reagent concentration detection device according to claim 3, characterized in that, The sealing cover plate includes a covering part, a connecting part, and a hinge part fixed in sequence. The hinge end of the sealing cover plate is located at the hinge part, and the covering end of the sealing cover plate is located at the covering part. A sealing ring is provided on one side of the covering part facing the detection groove. The sealing ring is used to surround the detection groove when the covering part is placed over the opening of the detection groove, and to press against the top end face of the concentration detector. The hinge part is hinged to the concentration detector.

5. The automatic reagent concentration detection device according to claim 4, characterized in that, The concentration detection component also includes a flip-top drive component. The flip-top drive end of the flip-top drive component is fixedly connected to the cover portion, and the flip-top drive end of the flip-top drive component is disposed away from the sealing ring. The flip-top drive end of the flip-top drive component is used to drive the cover portion to perform a closing or opening operation.

6. The automatic reagent concentration detection device according to claim 2, characterized in that, The automatic reagent concentration detection device also includes a frame, the top of which has a bearing mounting surface. The conveying mechanism and the pipetting mechanism are both mounted on the bearing mounting surface. The reagent cleaning assembly includes a fixed base and a cleaning component. The concentration detector is mounted on the bearing mounting surface. The fixed end of the cleaning component is fixed to the fixed base. The fixed base is slidably assembled to the frame. The fixed end of the moving drive assembly is fixedly connected to the frame. The driving end of the moving drive assembly is fixedly connected to the fixed base. The driving end of the moving drive assembly is used to drive the fixed base to slide relative to the frame. The cleaning end of the cleaning component is positioned opposite to the opening of the detection tank. The cleaning end of the cleaning component is used to clean the reagent in the detection tank.

7. The automatic reagent concentration detection device according to claim 6, characterized in that, The cleaning component includes a liquid-absorbing belt, an unwinding machine, and a winding machine. Both the unwinding machine and the winding machine are fixed to the fixed base, forming a transmission path between them. One end of the liquid-absorbing belt is wound around the winding end of the unwinding machine, and the unwinding machine releases the cleaned liquid-absorbing belt. The other end of the liquid-absorbing belt is wound around the winding end of the winding machine, and the winding machine collects the liquid-absorbing belt after absorption. The transmission path of the liquid-absorbing belt sequentially passes through the winding end of the unwinding machine, the concentration detection position of the concentration detection component, and the winding end of the winding machine. The liquid-absorbing belt located at the concentration detection position is used to absorb the reagent in the detection tank. A supporting flange protrudes from one side of the sealing cover facing the detection tank, and the supporting flange is correspondingly positioned to the detection tank. The supporting flange is used to push the liquid-absorbing belt to abut against the inner wall of the detection tank when the sealing cover is closed on the opening of the detection tank.

8. The automatic reagent concentration detection device according to claim 7, characterized in that, The reagent cleaning assembly also includes a driving cylinder and a holding member. The fixed end of the driving cylinder is fixed to the frame, and the driving end of the driving cylinder is fixedly connected to the holding member. The driving cylinder is used to drive the holding member to the opening of the detection tank. The holding member is provided with a supporting flange, which is correspondingly arranged with the detection tank. The holding member is used to push the liquid absorption belt to abut against the inner wall of the detection tank when it moves to the opening of the detection tank.

9. The automatic reagent concentration detection device according to claim 7, characterized in that, The reagent cleaning assembly also includes a liquid aspiration belt detector. The fixed end of the liquid aspiration belt detector is installed and fixed to the fixed base. The detection end of the liquid aspiration belt detector is arranged facing the transmission path and spaced apart from the cleaning component. The liquid aspiration belt detector is used to detect whether there is a liquid aspiration belt in the transmission path. The control end of the liquid aspiration belt detector is electrically connected to the control ends of the conveying mechanism, the pipetting mechanism and the cleaning component, respectively.

10. An automated reagent preparation device, characterized in that, The automatic reagent concentration detection device includes any one of claims 1 to 9.

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