Production type liposome extruder

Abstract

The utility model relates to the technical field of extruders, and discloses a production type lipidosome extruder which comprises a bottom plate, a vertical plate is arranged on the upper end face of the bottom plate and close to one side, a transverse plate is arranged at the lower end of the vertical plate, a barrel is arranged on the transverse plate, a cavity with an upward opening is formed in the barrel, and the cavity is used for containing lipidosome. A communicating groove communicated with the cavity is formed in the outer side wall of the barrel in the width direction of the barrel, a fixing plate extending into the cavity is arranged in the communicating groove, a filtering assembly used for filtering lipidosome is arranged on the fixing plate, a dismounting and mounting assembly is arranged on the opposite outer side wall of the barrel, a pressing plate is arranged on the vertical plate, a vertical cavity is formed in the vertical plate, and an extrusion assembly is arranged in the vertical cavity. By means of the structure, installation of the fixing plate at the communicating groove is removed through the disassembling and assembling assembly, the fixing plate can slide out of the communicating groove, and therefore a worker can conveniently replace the filtering plate and the lipidosome filtering membrane on the fixing plate, and the use effect is good.

Description

Technical Field

[0001] The utility model relates to the technical field of extruders, and specifically, to a production-type liposome extruder. Background Art

[0002] A liposome extruder, also known as a liposome extrusion instrument, mainly controls the sizing of liposome particles, and both its particle size and distribution need to be controlled within a good range. For example, the particle size is controlled below 100 nm, and the PDI distribution is controlled below 0.1. In the prior art, the sizing control of liposomes is generally achieved by high-pressure extrusion. The liposome particles are extruded through a PC polycarbonate filter membrane with a specific pore size by a power source, and under the shearing force of the filter membrane, the particle size of the liposome particles becomes smaller and the distribution becomes more uniform.

[0003] For example, a special tank body extruder for liposomes disclosed in the patent with the publication number CN213081961U solves the problems of poor temperature control effect of the existing liposome extruder and easy reduction of the finished product due to too high temperature of the liposome. However, when this special tank body extruder for liposomes is actually used, the liposome filter membrane is fixedly installed on the filter plate, and the filter plate is fixedly installed in the cylinder installation groove, so it is inconvenient for the staff to replace the filter plate and the liposome filter membrane, and thus it needs to be improved. Summary of the Utility Model

[0004] The purpose of the utility model is to provide a production-type liposome extruder to solve the problems raised in the above background art.

[0005] To achieve the above purpose, the utility model provides the following technical solutions:

[0006] A production-type liposome extruder includes a bottom plate. A vertical plate is provided at the upper end surface of the bottom plate and near one side. A horizontal plate is provided at the lower end of the vertical plate. A cylinder is provided on the horizontal plate. A cavity that opens upward and is used for containing liposomes is provided inside the cylinder. A communication groove communicating with the cavity is opened on the outer side wall of the cylinder along its width direction. A fixing plate extending into the cavity is provided in the communication groove. A filtering component for filtering liposomes is provided on the fixing plate. Disassembly and assembly components for disassembling and assembling the fixing plate at the communication groove are provided at the opposite outer side walls of the cylinder. A pressing plate is provided on the vertical plate. A vertical cavity is provided inside the vertical plate. An extrusion component for driving the pressing plate to extrude the liposomes in the cavity is provided in the vertical cavity.

[0007] Preferably, a vertical groove communicating with the vertical cavity is opened on the front side wall of the vertical plate along its height direction;

[0008] The extrusion assembly includes a rotatable rotating circular plate disposed in the vertical cavity. Protrusions are provided on the end face of the rotating circular plate near the edge. A movable plate is also provided in the vertical cavity. A movable groove for the protrusions to snap into is formed along the length direction on the rear side wall of the movable plate. A movable rod with one end extending out of the vertical groove is provided on the front side wall of the movable plate. A connecting rod with one end connected to the pressing plate is provided on the extending end of the movable rod. The rotation of the rotating circular plate drives the lifting of the movable plate, realizing that the movable rod drives the connecting rod to drive the pressing plate to extrude the liposomes in the cavity.

[0009] Preferably, one end of the fixing plate extends out of the communicating groove. An installation plate is provided at the extending end of the fixing plate. Box bodies are provided at the opposite outer side walls of the cylinder body. Cavities are provided in the box bodies. A sliding groove communicating with the cavity is formed along the height direction on one side wall of the box body.

[0010] The disassembly and assembly component includes opposite support plates disposed in the cavity. A liftable lifting plate is provided between the two support plates. A sliding plate with one end extending out of the sliding groove is provided at one end of the lifting plate. A limiting plate is provided at one end of the sliding plate. Round rods with one end passing through the lifting plate are provided on the support plates. Springs are sleeved on the round rods. The springs are used to push the lifting plate to move towards the support plates. The movement of the lifting plate drives the limiting plate on the sliding plate to limit the installation plate, realizing the installation of the fixing plate at the communicating groove. A driving member for releasing the limiting of the installation plate by the limiting plate is provided in the cavity.

[0011] Preferably, the driving member includes a rotatable driving rod disposed under the lifting plate. A driving circular plate is provided on the driving rod. A swinging rod is provided at the edge of the driving circular plate. The driving circular plate drives the swinging rod to rotate, realizing that the swinging rod pushes the lifting plate to move upward and releases the limiting of the installation plate by the limiting plate.

[0012] Preferably, one end of the driving rod extends out of the box body. A handle for driving the driving rod to rotate is provided at the extending end of the driving rod.

[0013] Preferably, a handle for pulling the installation plate to move is provided on the installation plate.

[0014] Preferably, clamping blocks are provided along the height direction on the opposite side walls of the vertical cavity. Card slots for snapping into the corresponding clamping blocks are formed at both ends of the movable plate.

[0015] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0016] 1. In the present utility model, the installation of the fixing plate at the communicating groove is released through the disassembly and assembly component, enabling the fixing plate to slide out from the communicating groove. Compared with the existing ones, when this production-type liposome extruder is actually used, it is convenient for the staff to replace the filter plate and the liposome filter membrane on the fixing plate, and the use effect is better.

[0017] 2. In this utility model, through the cooperation of the clamping block and the clamping groove, the lifting of the moving plate in the vertical cavity is made more stable, so as to better drive the pressing plate to extrude the liposome. Description of the Drawings

[0018] Figure 1 It is a schematic structural diagram of a production-type liposome extruder in this utility model.

[0019] Figure 2 It is a schematic cross-sectional structure diagram of the vertical plate in this utility model.

[0020] Figure 3 It is a schematic structural diagram of the moving plate in this utility model.

[0021] Figure 4 It is a schematic cross-sectional structure diagram of the cylinder body in this utility model.

[0022] Figure 5 It is Figure 1 an enlarged schematic structural diagram of part A in

[0023] Figure 6 It is a schematic structural diagram inside the box body in this utility model.

[0024] The meanings of the labels in the figure are as follows:

[0025] 100, bottom plate; 110, vertical plate; 111, vertical groove; 120, cross plate; 130, cylinder body; 131, cavity; 140, pressing plate; 150, moving rod; 151, connecting rod; 160, mounting plate; 161, handle.

[0026] 201, vertical cavity; 210, rotating circular plate; 211, convex block; 220, moving plate; 230, clamping block; 240, motor.

[0027] 301, moving groove; 302, clamping groove.

[0028] 400, fixing plate; 410, discharge pipe.

[0029] 500, box body; 501, sliding groove; 510, sliding plate; 511, limiting plate; 520, handle.

[0030] 601, cavity; 610, support plate; 620, lifting plate; 630, round rod; 640, spring; 650, driving rod; 651, driving circular plate; 652, swing rod. Detailed Embodiment

[0031] To further understand the content of this utility model, the utility model will be described in detail in combination with the drawings and embodiments. It should be understood that the embodiments are only for explaining the utility model rather than limiting it.

[0032] The following will further elaborate on this embodiment in conjunction with the attached Figures 1-6 drawings.

[0033] As Figure 1 shown, a production-type liposome extruder in this embodiment includes a bottom plate 100. A vertical plate 110 is provided on the upper end surface of the bottom plate 100 and near one side. A horizontal plate 120 is provided at the lower end of the vertical plate 110. A cylinder 130 is provided on the horizontal plate 120. A cavity 131 with an upward opening for containing liposomes is provided inside the cylinder 130. A communication groove communicating with the cavity 131 is opened on the outer side wall of the cylinder 130 along its width direction. A fixing plate 400 extending into the cavity 131 is provided in the communication groove. A filtering assembly for filtering liposomes is provided on the fixing plate 400. Disassembly and assembly components for disassembling and assembling the fixing plate 400 at the communication groove are provided at opposite outer side walls of the cylinder 130. A pressing plate 140 is provided on the vertical plate 110. A vertical cavity 201 is provided inside the vertical plate 110. An extrusion assembly for driving the pressing plate 140 to extrude the liposomes in the cavity 131 is provided inside the vertical cavity 201.

[0034] In this embodiment, mounting holes for mounting the filtering assembly are provided on the fixing plate 400 corresponding to the cavity 131. The filtering assembly includes a filter plate and a liposome filter membrane mounted in the mounting holes. When the fixing plate 400 is inserted into the cavity 131 from the communication groove, both the filter plate and the liposome filter membrane are located inside the cavity 131. Then, the fixing plate 400 is fixed at the communication groove through the disassembly and assembly components, that is, the filter plate and the liposome filter membrane are installed inside the cavity 131. When liposomes are added into the cavity 131, the liposomes will be located on the filter plate and the liposome filter membrane. At this time, the extrusion assembly inside the vertical cavity 201 drives the pressing plate 140 to move downward to extrude the liposomes, so that the pressing plate 140 can extrude the liposomes on the filter plate and the liposome filter membrane, and then the liposomes with smaller particle sizes can be located below the filter plate and the liposome filter membrane, thereby realizing the extrusion of liposomes and enabling the particle size of the liposomes to be controlled within a better range. Among them, in order to enable the pressing plate 140 to better extrude the liposomes, the outer side wall of the pressing plate 140 is in sliding and airtight fit with the side wall of the cavity 131.

[0035] Among them, a discharge pipe 410 penetrating through the horizontal plate 120 is installed on the lower end surface of the cylinder 130. When the extrusion of liposomes is completed, the extruded liposome particles can be discharged from the cavity 131.

[0036] Among them, the cavity 131 below the fixing plate 400 is in a funnel shape, so that the extruded liposome particles all approach the discharge pipe 410, thereby enabling the discharge pipe 410 to better discharge the extruded liposome particles.

[0037] Among them, the vertical plate 110 is fixedly installed on the bottom plate 100, the horizontal plate 120 is fixedly installed on the vertical plate 110, and the cylinder 130 is fixedly installed on the horizontal plate 120;

[0038] Among them, when it is necessary to replace the filter plate and the liposome filter membrane on the fixed plate 400, the installation of the fixed plate 400 at the communication groove is released through the disassembly and assembly component, so that the fixed plate 400 can slide out from the communication groove. Compared with the existing ones, when this production-type liposome extruder is actually used, it can facilitate the staff to replace the filter plate and the liposome filter membrane on the fixed plate 400, and the use effect is better;

[0039] When it is actually used, the length of the communication groove is longer than the diameter of the cavity 131, so that when the fixed plate 400 is inserted into the cavity 131, both sides of the fixed plate 400 can overlap at the two end parts of the communication groove, thereby making the installation effect of the fixed plate 400 in the cavity 131 better;

[0040] When it is actually used, in order to ensure the sealing performance when the fixed plate 400 is inserted, a sealing gasket that closely adheres to the side wall of the communication groove is coated around the fixed plate 400.

[0041] As Figures 1-3 shown, in this embodiment, a vertical groove 111 communicating with the vertical cavity 201 is formed on the front side wall of the vertical plate 110 along its height direction;

[0042] The extrusion assembly includes a rotatable rotating circular plate 210 disposed in the vertical cavity 201. A convex block 211 is provided on the end surface of the rotating circular plate 210 and near the edge. A movable plate 220 is also provided in the vertical cavity 201. A moving groove 301 for the convex block 211 to be inserted is formed on the rear side wall of the movable plate 220 along its length direction. A moving rod 150 with one end extending out of the vertical groove 111 is provided on the front side wall of the movable plate 220. A connecting rod 151 with one end connected to the pressing plate 140 is provided on the extending end of the moving rod 150. The rotation of the rotating circular plate 210 drives the movable plate 220 to move up and down, realizing that the moving rod 150 drives the connecting rod 151 to drive the pressing plate 140 to extrude the liposome in the cavity 131.

[0043] In this embodiment, through the settings of the vertical groove 111, the rotating circular plate 210, the convex block 211, the moving plate 220, the moving groove 301, the moving rod 150 and the connecting rod 151, by fixedly installing the convex block 211 on the rotating circular plate 210, fixedly installing the moving rod 150 on the moving plate 220, fixedly connecting one end of the connecting rod 151 to the pressing plate 140, and connecting the other end of the connecting rod 151 to the moving rod 150, when the rotating circular plate 210 drives the convex block 211 to rotate along the circumferential direction of the rotating circular plate 210, the convex block 211 can drive the moving plate 220 to lift in the vertical cavity 201. The lifting of the moving plate 220 drives the moving rod 150 to lift along the vertical groove 111, and the lifting of the moving rod 150 can drive the pressing plate 140 to lift through the connecting rod 151, so as to realize the extrusion of the liposomes in the cavity 131 by the pressing plate 140;

[0044] Wherein, the opposite side walls of the moving plate 220 are in sliding fit with the corresponding side walls of the vertical cavity 201, so that the vertical cavity 201 limits the moving plate 220. When the rotating circular plate 210 drives the convex block 211 to rotate, the convex block 211 slides in the moving groove 301, so as to realize the lifting of the moving plate 220 in the vertical cavity 201;

[0045] Wherein, clamping blocks 230 are fixedly installed on the opposite side walls of the vertical cavity 201 along the height direction thereof, and clamping grooves 302 for clamping into the corresponding clamping blocks 230 are formed at both ends of the moving plate 220. Through the cooperation of the clamping blocks 230 and the clamping grooves 302, the lifting of the moving plate 220 in the vertical cavity 201 is more stable, so as to better drive the pressing plate 140 to extrude the liposomes;

[0046] During actual use, a motor 240 is fixedly installed on the side wall of the vertical plate 110, the output shaft of the motor 240 extends into the vertical cavity 201, and the central position of the rotating circular plate 210 is fixedly installed on the output shaft of the motor 240, so that the rotating circular plate 210 can be driven to rotate by the motor 240.

[0047] As Figures 1-6 shown, in this embodiment, one end of the fixing plate 400 extends out of the communication groove, an installation plate 160 is provided at the extended end of the fixing plate 400, box bodies 500 are provided at the opposite outer side walls of the cylinder 130, cavities 601 are provided in the box bodies 500, and a sliding groove 501 communicating with the cavity 601 is formed on one side wall of the box body 500 along the height direction thereof;

[0048] The disassembly and assembly component includes opposing support plates 610 disposed within the cavity 601. An elevating plate 620 is disposed between the two support plates 610 and is capable of ascending and descending. At one end of the elevating plate 620, there is a sliding plate 510 with one end extending outside the sliding groove 501. At one end of the sliding plate 510, there is a limiting plate 511. Round rods 630 each having one end penetrating through the elevating plate 620 are disposed on the support plates 610. Spring 640 is sleeved on each round rod 630. The spring 640 is used to push the elevating plate 620 to move towards the support plate 610. The movement of the elevating plate 620 drives the limiting plate 511 on the sliding plate 510 to limit the mounting plate 160, thereby achieving the installation of the fixing plate 400 at the communication groove. A driving member for releasing the limiting of the mounting plate 160 by the limiting plate 511 is disposed within the cavity 601.

[0049] In this embodiment, through the arrangement of the mounting plate 160, the box body 500, the cavity 601, the sliding groove 501, the support plates 610, the elevating plate 620, the sliding plate 510, the limiting plate 511, the round rods 630, the spring 640, and the driving member, by fixedly installing the mounting plate 160 on the fixing plate 400, the box body 500 on the cylinder body 130, and the support plates 610 on the bottom wall of the cavity 601, both ends of the elevating plate 620 are lapped on the corresponding support plates 610, thereby achieving the installation of the elevating plate 620 within the cavity 601. The sliding plate 510 is fixedly installed on the elevating plate 620, the limiting plate 511 is fixedly installed on the sliding plate 510, the round rods 630 are fixedly installed on the support plates 610, and the spring 640 is located on the round rods 630 between the side wall of the cavity 601 and the support plates 610. When the fixing plate 400 is located within the communication groove, the mounting plate 160 abuts against the side wall of the cylinder body 130. At this time, the spring 640 pushes the moving plate 220 to move towards the support plate 610, and the movement of the support plate 610 drives the sliding plate 510 to slide along the sliding groove 501. When the sliding plate 510 is lapped on the mounting plate 160, the side wall of the limiting plate 511 abuts against the side wall of the mounting plate 160, thereby achieving the installation of the mounting plate 160 on the cylinder body 130, that is, the fixing plate 400 is installed within the communication groove.

[0050] Among them, when it is necessary to remove the installation of the mounting plate 160 on the cylinder body 130, the driving member drives the moving plate 220 to move upward. The movement of the moving plate 220 drives the limiting plate 511 to move upward through the sliding plate 510, so that the limiting plate 511 releases the abutment with the mounting plate 160. At this time, the installation of the mounting plate 160 within the cylinder body 130 can be removed, and the staff can pull out the fixing plate 400 from the communication groove through the mounting plate 160 to replace the filter plate and the liposome filter membrane.

[0051] During its actual use, a handle 161 for pulling the mounting plate 160 to move is fixedly installed on the mounting plate 160. Through the handle 161, it is convenient for the staff to drive the mounting plate 160 to pull out the fixing plate 400 from the communication groove.

[0052] As Figures 1-6 shown, in this embodiment, the driving member includes a rotatable driving rod 650 disposed under the lifting plate 620. A driving circular plate 651 is provided on the driving rod 650, and a swing rod 652 is provided at the edge of the driving circular plate 651. The driving circular plate 651 drives the swing rod 652 to rotate, so that the swing rod 652 pushes the lifting plate 620 to move upward, releasing the limitation of the limiting plate 511 on the mounting plate 160.

[0053] In this embodiment, through the arrangement of the driving rod 650, the driving circular plate 651 and the swing rod 652, the driving rod 650 is rotatably mounted on the bottom wall of the cavity 601 through a bearing seat, the driving circular plate 651 is fixedly mounted on the driving rod 650, and the swing rod 652 is fixedly mounted on the driving circular plate 651. When the driving rod 650 drives the driving circular plate 651 to rotate, the driving circular plate 651 drives the swing rod 652 to rotate along the circumference of the driving circular plate 651. When the swing rod 652 rotates, one end of the swing rod 652 pushes the lifting plate 620 to move upward, thereby releasing the abutment of the limiting plate 511 on the mounting plate 160;

[0054] In actual use, one end of the driving rod 650 extends outside the box body 500, and a handle 520 for driving the driving rod 650 to rotate is fixedly mounted on the extending end of the driving rod 650. It is convenient for the staff to rotate the driving rod 650 through the handle 520, and it is more convenient to use.

[0055] Working principle: First, add liposomes into the cavity 131. Then, drive the rotating circular plate 210 to rotate through the motor 240, so that the moving plate 220 can drive the connecting rod 151 to move downward through the moving rod 150, so that the pressing plate 140 can extrude the liposomes in the cavity 131, and the extruded liposomes are discharged through the discharge pipe 410; When it is necessary to replace the filter plate and the liposome filter membrane on the fixing plate 400, drive the driving rod 650 to rotate through the handle 520, so that the driving circular plate 651 drives the swing rod 652 to push the lifting plate 620 to move upward. The upward movement of the lifting plate 620 drives the limiting plate 511 to move upward through the sliding plate 510, releasing the abutment of the limiting plate 511 on the mounting plate 160. At this time, the staff drives the mounting plate 160 to move through the pulling handle 161, and the fixing plate 400 can be pulled out from the communication groove, and the filter plate and the liposome filter membrane on the fixing plate 400 can be replaced. After the replacement of the filter plate and the liposome filter membrane is completed, insert the fixing plate 400 into the communication groove, and the spring 640 pushes the lifting plate 620 to move, so that the limiting plate 511 abuts on the mounting plate 160, and the fixed installation of the mounting plate 160 on the cylinder body 130 can be realized.

Claims

1. A production type liposome extruder, characterized in that: The invention comprises a bottom plate (100), a vertical plate (110) is provided on the upper end surface of the bottom plate (100) and near one side, a horizontal plate (120) is provided at the lower end of the vertical plate (110), a cylinder (130) is provided on the horizontal plate (120), a cavity (131) is provided in the cylinder (130) and is opened upward and is used to contain liposomes, a connecting groove is provided on the outer wall of the cylinder (130) along its width direction and is connected to the cavity (131), and a connecting groove is provided in the connecting groove to extend into the cavity (131). A fixed plate (400) is provided on the fixed plate (400), a filtering assembly for filtering liposomes is provided on the fixed plate (400), a disassembly assembly for disassembling and assembling the fixed plate (400) at the connecting groove is provided on the outer side wall opposite to the cylinder (130), a pressing plate (140) is provided on the vertical plate (110), a vertical cavity (201) is provided in the vertical plate (110), and an extrusion assembly for driving the pressing plate (140) to extrude the liposomes in the cavity (131) is provided in the vertical cavity (201).

2. A production type liposome extruder according to claim 1, characterized in that: A vertical groove (111) communicating with the vertical cavity (201) is provided on the front side wall of the vertical plate (110) along its height direction; The extrusion assembly comprises a rotating circular plate (210) which is arranged in the vertical cavity (201) and is rotatable. A protrusion (211) is provided on the end surface of the rotating circular plate (210) and near the edge. A movable moving plate (220) is also provided in the vertical cavity (201). A moving groove (301) for the protrusion (211) to be inserted is provided on the rear side wall of the moving plate (220) along its length direction. A moving rod (150) with one end extending out of the vertical groove (111) is provided on the front side wall of the moving plate (220). A connecting rod (151) with one end connected to the pressing plate (140) is provided on the protruding end of the moving rod (150). The rotating circular plate (210) rotates to drive the moving plate (220) to move up and down, so that the moving rod (150) drives the connecting rod (151) to drive the pressing plate (140) to extrude the liposomes in the cavity (131).

3. A production type liposome extruder according to claim 1, characterized in that: One end of the fixing plate (400) is arranged to extend outside the connecting groove, and a mounting plate (160) is provided at the extending end of the fixing plate (400). Box bodies (500) are provided at opposite outer side walls of the cylinder (130), and cavities (601) are provided in the box bodies (500). A sliding groove (501) connecting the cavities (601) is provided on one side wall of the box body (500) along its height direction; The disassembly assembly comprises supporting plates (610) arranged in the cavity (601) and facing each other, a lifting plate (620) that can be lifted and lowered is arranged between the two supporting plates (610), a slide plate (510) with one end extending out of the slide groove (501) is arranged at one end of the lifting plate (620), a limiting plate (511) is arranged at one end of the slide groove (510), a round rod (630) with one end penetrating the lifting plate (620) is arranged on the supporting plates (610), a spring (640) is sleeved on the round rod (630), the spring (640) is used to push the lifting plate (620) to move toward the supporting plate (610), the lifting plate (620) moves to drive the limiting plate (511) on the slide plate (510) to limit the mounting plate (160), so as to realize the installation of the fixing plate (400) at the connecting groove, and a driving member for releasing the limiting plate (511) from limiting the mounting plate (160) is arranged in the cavity (131).

4. A production type liposome extruder according to claim 3, characterized in that: The driving member comprises a rotatable driving rod (650) disposed under the lifting plate (620); a driving circular plate (651) is disposed on the driving rod (650); a swinging rod (652) is disposed at the edge of the driving circular plate (651); the driving circular plate (651) drives the swinging rod (652) to rotate, so that the swinging rod (652) pushes the lifting plate (620) to move upward, thereby releasing the limit plate (511) from limiting the mounting plate (160).

5. A production type liposome extruder according to claim 1, characterized in that: One end of the driving rod (650) is arranged to extend outside the box body (500), and the extended end of the driving rod (650) is provided with a handle (520) for driving the driving rod (650) to rotate.

6. A production type liposome extruder according to claim 3, characterized in that: A handle (161) for pulling the mounting plate (160) to move is provided on the mounting plate (160).

7. A production type liposome extruder according to claim 1, characterized in that: A clamping block (230) is provided on the side wall opposite to the vertical cavity (201) along its height direction, and clamping grooves (302) for clamping into corresponding clamping blocks (230) are provided at both ends of the movable plate (220).

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