Liver organ metabolism system micro-fluidic chip
By constructing a microfluidic chip for liver organoid metabolism, and combining microfluidics and organoid technology, the shortcomings of existing in vitro liver models have been addressed, enabling more accurate simulation of drug metabolism and substance exchange, and simulating the structure and function of the human liver.
CN223723141UActive Publication Date: 2025-12-26INST OF HEALTH & MEDICINE HEFEI COMPREHENSIVE NAT SCI CENT +1
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Patent Information
- Application Number
- CN202423151497.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-19
- Publication Date
- 2025-12-26
- Estimated Expiration
- 2034-12-19
Smart Images
Figure CN223723141U_ABST
Abstract
The utility model discloses a liver organ metabolism system micro-fluidic chip which comprises a liver organ channel, a side edge channel and a top layer channel, the side edge channel is located on one side of the liver organ channel, and the side edge channel and the liver organ channel are located at the same horizontal position; array micro-columns are arranged at the communication positions of the side channels and the liver organ channel; the top layer channel is located above the liver organ channel, and a porous membrane is arranged at the communicating position of the top layer channel and the liver organ channel. The array micro-columns are arranged at the communicating positions of the liver organ-like channels and the side channels, so that an interface formed by matrigel can be in more contact with a culture medium of the channels, material exchange is enhanced, and the organ-like culture efficiency is improved; according to the application, the top layer channel is designed above the liver organ channel, and the porous membrane is arranged at the communication position of the top layer channel and the liver organ channel, so that a better bionic effect can be achieved. The chip can accurately simulate the metabolic process of the medicine in the liver.
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