Experimental animal pressure modeling box
By designing an experimental animal stress modeling chamber and utilizing partitions and baffles, uniform stimulation of mice by various stressors was achieved, solving the problem of low efficiency in large-scale mouse stress modeling in existing technologies, and improving experimental efficiency and ease of use of the equipment.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-19
- Publication Date
- 2026-04-03
AI Technical Summary
Existing methods for establishing mouse stress models are not simple enough, making it difficult to ensure that each mouse receives the same intensity of stress stimulation when creating large-scale models. Furthermore, existing equipment is mostly used for single mice, resulting in low efficiency.
A laboratory animal stress modeling chamber was designed, comprising a chamber body, partitions and multiple partitions. The partitions divide the chamber into a first cavity and a second cavity, and the partitions divide the second cavity into multiple placement chambers. Each placement chamber is used to accommodate one laboratory animal. The cover can be opened and closed to achieve stimulation from multiple stressors and ensure that each animal receives stimulation of the same intensity.
It improves the efficiency of rodent stress experiments, ensures that each animal receives uniform stress stimulation, simplifies large-scale experimental operations, and enhances the efficiency and ease of cleaning of the equipment.
Smart Images
Figure CN224069430U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of life science research equipment technology, and in particular to a pressure modeling box for laboratory animals. Background Technology
[0002] In today's society, people face various pressures, and the continuous accumulation of these pressures can induce mental illnesses such as depression, seriously endangering human physical and mental health. Current scientific research involves stimulating mice with various stressors to create stress models. Commonly used models include the forced swimming test in mice and rats, the tail suspension test, learned helplessness models, social failure stress models, and chronic restraint stress models. However, current methods for creating stress models in mice are not simple enough. Most of the modeling equipment used is only suitable for single mice. When creating models in large numbers, it requires a lot of time and effort, and it cannot be guaranteed that each mouse receives the same intensity of stress stimulation.
[0003] Therefore, there is an urgent need to develop an experimental animal stress modeling chamber that can use multiple stressors to stimulate mice, allowing each animal to receive the same intensity of stimulation, thereby improving the efficiency of stress stress experiments on rodents in biological experiments. Utility Model Content
[0004] The purpose of this invention is to provide a laboratory animal stress modeling chamber that can use a variety of stressors to stimulate mice, allowing each animal to receive the same intensity of stimulation, thereby improving the efficiency of stress stress experiments on rodents in biological experiments.
[0005] To achieve this objective, the present invention adopts the following technical solution:
[0006] This utility model discloses a pressure modeling box for laboratory animals, comprising: a box body having a receiving cavity; a partition installed on the box body, dividing the receiving cavity into a first cavity and a second cavity, the second cavity being located radially outside the first cavity, the first cavity being used to place a pressure stimulus source; multiple partitions installed on the second cavity, dividing the second cavity into multiple placement cavities, the multiple placement cavities being evenly distributed along the circumference of the first cavity, and each placement cavity being used to accommodate one laboratory animal; and multiple cover plates, the multiple cover plates being closably installed on the box body, the multiple cover plates being correspondingly arranged with the multiple receiving cavities.
[0007] In some embodiments, the partition is detachably connected to the box body; wherein, a first slot is provided on one of the bottom wall of the partition and the bottom wall of the box body, and a first insertion protrusion that mates with the first slot is provided on the other of the bottom wall of the partition and the bottom wall of the box body.
[0008] In some specific embodiments, there are multiple first slots, which are distributed at intervals along the circumference of the first cavity, and there are multiple first insertion protrusions, which are configured to correspond one-to-one with the multiple first slots.
[0009] In some embodiments, the first end of each of the covers engages with the top wall of the box body via a hinge, and the second ends of the plurality of covers enclose a receiving hole.
[0010] In some embodiments, one of the two adjacent cover plates is provided with a latching protrusion, and the other cover plate is provided with a latching groove. The two adjacent cover plates are connected by the latching protrusion and the latching groove.
[0011] In some embodiments, the inner sidewall of the box body and / or the inner sidewall of the partition are provided with mounting grooves, and the sidewall of the partition is slidably mounted in the mounting groove along the height direction of the box body.
[0012] In some embodiments, a second slot is provided on one of the bottom walls of the partition and the bottom wall of the box body, and a second insertion protrusion that mates with the second slot is provided on the other of the bottom walls of the partition and the bottom wall of the box body.
[0013] In some embodiments, the separator is provided with a plurality of first vent holes, which are distributed at intervals along the circumference and axial direction of the separator.
[0014] In some embodiments, the cover plate is provided with a plurality of second vent holes, which are arranged in a circumferential array.
[0015] In some embodiments, at least one third vent hole is provided on the side wall of the partition.
[0016] The beneficial effects of this experimental animal stress modeling box are as follows: Because the box body is equipped with a partition and multiple baffles, the partition divides the box body into a first cavity and a second cavity. The first cavity is used to place the pressure stimulus source, and the multiple baffles divide the second cavity into multiple placement cavities, each of which is used to accommodate one experimental animal. In actual experiments, multiple stressors can be used to stimulate the experimental animals, and each experimental animal can receive the same intensity of stimulation, thereby improving the efficiency of stress stress experiments on rodents in biological experiments.
[0017] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description
[0018] Figure 1 This is a schematic diagram of the structure of the experimental animal pressure modeling box according to an embodiment of the present invention;
[0019] Figure 2 This is a top view of the experimental animal pressure modeling box according to an embodiment of the present invention;
[0020] Figure 3 This is an exploded structural diagram of the experimental animal pressure modeling box according to an embodiment of the present invention.
[0021] Figure label:
[0022] 100. Box body; 101. First cavity; 102. Placement cavity;
[0023] 200. Separator; 210. First vent;
[0024] 300. Partition; 310. Third vent;
[0025] 400, cover plate; 410, second vent; 420, receiving hole;
[0026] 500. Hinge. Detailed Implementation
[0027] The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the present invention, not the entire structure.
[0028] In the description of this utility model, unless otherwise explicitly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.
[0029] In the description of this embodiment, the terms "upper," "lower," "left," "right," "front," and "rear," etc., refer to the orientation or positional relationship shown in the accompanying drawings. They are used only for ease of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. In addition, the terms "first" and "second" are only used for distinction in description and have no special meaning.
[0030] This utility model discloses a pressure modeling box for laboratory animals, with reference to... Figures 1 to 3 As shown, the experimental animal pressure modeling box disclosed in this utility model includes a box body 100, a partition 200, multiple cover plates 400 and multiple partitions 300. The box body 100 has a receiving cavity. The partition 200 is installed on the box body 100 and divides the receiving cavity into a first cavity 101 and a second cavity. The second cavity is located radially outside the first cavity 101. The first cavity 101 is used to place a pressure stimulus source. Multiple partitions 300 are installed on the second cavity and divide the second cavity into multiple placement cavities 102. The multiple placement cavities 102 are evenly distributed along the circumference of the first cavity 101, and each placement cavity 102 is used to accommodate one experimental animal. Multiple cover plates 400 are closable and installed on the box body 100. The multiple cover plates 400 are correspondingly arranged with the multiple receiving cavities. Logically, because the experimental animal pressure modeling box 100 of this invention has a partition 200 and multiple partitions 300 inside, the partition 200 divides the accommodating cavity of the box body 100 into a first cavity 101 and a second cavity. The first cavity 101 is used to place pressure stimuli, and the multiple partitions 300 divide the second cavity into multiple placement cavities 102, with each placement cavity 102 designed to accommodate one experimental animal. In actual experiments, multiple stressors can be used to stimulate the experimental animals, and each experimental animal can receive the same intensity of stimulation, thus improving the efficiency of pressure stress experiments on rodents in biological experiments. The added cover 400 can seal the placement cavities 102, preventing the experimental animals from climbing out of the placement cavities 102.
[0031] It should be further explained that multiple cover plates 400 are correspondingly arranged with multiple receiving cavities. Multiple cover plates 400 and multiple receiving cavities can be arranged directly opposite each other, that is, one cover plate 400 is fastened to the top wall of one receiving cavity; multiple cover plates 400 and multiple receiving cavities can also be staggered and corresponding, that is, one cover plate 400 is fastened to the position between two adjacent receiving cavities. Here, corresponding arrangement means that the number is equal.
[0032] Optionally, the separator 200 is detachably connected to the box body 100. It is understood that if the experimental animal needs to be replaced after the actual experiment, the experimental animal pressure molding box needs to be cleaned. Setting the separator 200 and the box body 100 as a detachable connection structure allows the separator 200 to be separated from the box body 100 when cleaning is required. This facilitates the cleaning operation and also helps to improve the cleaning effect.
[0033] Optionally, a first slot (not shown) is provided on one of the bottom walls of the partition 200 and the box body 100, and a first insertion protrusion (not shown) is provided on the other of the bottom walls of the partition 200 and the box body 100 to mate with the first slot. It is understood that the detachable connection between the partition 200 and the box body 100 is achieved through the first slot and the first insertion protrusion. This facilitates the installation and removal of the partition 200 from the box body, and also enhances the connection strength between the partition 200 and the box body 100, preventing the partition 200 from tilting due to the movement of experimental animals, thus affecting the experimental results.
[0034] Alternatively, there may be multiple first slots, distributed circumferentially along the first cavity 101, and multiple first insertion protrusions, each corresponding to one of the first slots. It is understood that the cooperation of multiple first slots and first insertion protrusions can further enhance the connection strength between the separator 200 and the box body 100, preventing the separator 200 from tilting due to the movement of experimental animals and thus affecting the experimental results.
[0035] It should be further noted that, in some embodiments, the bottom wall of the partition 200 is provided with a first slot, and the bottom wall of the box body 100 is provided with a first insertion protrusion; in other embodiments, the bottom wall of the partition 200 is provided with a first insertion protrusion, and the bottom wall of the box body 100 is provided with a first slot; in the embodiments of this utility model, the distribution of the first insertion protrusion and the first slot can be selected according to actual needs. Furthermore, the first insertion protrusion can be elongated or cylindrical, and the specific shapes of the first slot and the first insertion protrusion can be adjusted according to actual needs; therefore, no limitation is made on the specific shapes of the first slot and the first insertion protrusion here.
[0036] Optionally, the first end of each cover plate 400 engages with the top wall of the box body 100 via a hinge 500, and the second ends of multiple cover plates 400 together form a receiving hole 420. It is understood that the cover plate 400 is connected to the box body 100 via the hinge 500, facilitating the opening and closing of the cover plate 400. The second ends of multiple cover plates 400 together form the receiving hole 420, allowing for the placement of experimental animals into the placement cavity 102, followed by the insertion of a pressure stimulus source through the receiving hole 420. It should also be noted that in other embodiments of this invention, the cover plate 400 can be rotatably attached to the box body 100 via hinges, pivots, or other means.
[0037] Optionally, in two adjacent cover plates 400, one cover plate 400 has a latching protrusion, and the other cover plate 400 has a latching groove. The two adjacent cover plates 400 are connected by the latching protrusion and the latching groove. It can be understood that when multiple cover plates 400 are closed, the two adjacent cover plates 400 can be connected by the latching protrusion and the latching groove, which can improve the firmness of the cover plates 400 in the closed state and prevent the cover plates 400 from being opened by the experimental animals, thus preventing the experimental animals from crawling out of the placement cavity 102.
[0038] Optionally, the inner sidewall of the box body 100 and / or the inner sidewall of the partition 200 are provided with mounting grooves (not shown in the figure), and the sidewall of the partition 300 is slidably installed in the mounting groove along the height direction of the box body 100. It can be understood that in the actual assembly process, the sidewall of the partition 300 can be aligned with the mounting groove and then inserted into the mounting groove along the height direction of the box body 100, which can easily realize the installation and removal of the partition 300.
[0039] Optionally, a second slot is provided on one of the bottom walls of the partition 300 and the box body 100, and a second insertion protrusion is provided on the other of the bottom walls of the partition 300 and the box body 100 to mate with the second slot. It is understood that by aligning the side wall of the partition 300 with the mounting groove and inserting it into the mounting groove along the height direction of the box body 100, it is ensured that the second slot engages with the second insertion protrusion. This guarantees the connection strength between the partition 300 and the box body 100, preventing the partition 300 from tilting due to the movement of experimental animals, thus affecting the experimental results.
[0040] It should be further noted that, in some embodiments, the bottom wall of the partition 300 is provided with a second slot, and the bottom wall of the box body 100 is provided with a second insertion protrusion; in other embodiments, the bottom wall of the partition 300 is provided with a second insertion protrusion, and the bottom wall of the box body 100 is provided with a second slot; in the embodiments of this utility model, the distribution of the second insertion protrusion and the second slot can be selected according to actual needs. Furthermore, the second insertion protrusion can be elongated or cylindrical, and the specific shapes of the second slot and the second insertion protrusion can be adjusted according to actual needs; therefore, no limitation is made on the specific shapes of the second slot and the second insertion protrusion here.
[0041] Optionally, the partition 200 is provided with a plurality of first vent holes 210, which are distributed at intervals along the circumference and axial direction of the partition 200. It is understood that the provided first vent holes 210 can ensure that the placement cavity 102 is connected to the external environment, and the circulating air can ensure that the experimental animals can move within the placement cavity 102, avoiding the occurrence of experimental animal death due to hypoxia.
[0042] In some embodiments, the cover plate 400 is provided with a plurality of second vent holes 410, which are arranged in a circumferential array. It is understood that the provided second vent holes 410 can ensure that the placement cavity 102 is connected to the external environment, and the circulating air can ensure that the experimental animals can move within the placement cavity 102, avoiding the occurrence of experimental animal death due to hypoxia.
[0043] In some embodiments, at least one third vent 310 is provided on the side wall of the partition 300. It is understood that the third vent 310 ensures that two adjacent placement cavities 102 are connected, so that the entire second cavity is in a connected state, and the circulating air can ensure that the experimental animals can move in the placement cavity 102, avoiding the phenomenon of experimental animals dying due to hypoxia.
[0044] The specific shape and dimensions of the experimental animal pressure modeling chamber in this embodiment are described below.
[0045] The experimental animal pressure modeling chamber of this embodiment is made of acrylic material and can be autoclaved to ensure its cleanliness. The chamber body 100 has a diameter of 55 cm and a height of 30 cm. The partition 200 has a diameter of 25 cm and a height of 30 cm, and the side wall of the partition 200 is uniformly perforated with first ventilation holes 210 of 0.5 cm in diameter at 1 cm intervals. The pressure stress source is placed in the first cavity 101 radially inner side of the partition 200. Connected to the partition 200 are eight partitions 300, which divide the second cavity radially outer side of the partition 200 into eight placement cavities 102, which can be used to model eight mice simultaneously. Each placement cavity 102 has two third ventilation holes 310 of 1 cm in diameter at a height of 10 cm on its side. There is a 1 cm gap between two adjacent cover plates 400, with a receiving hole 420 of 4 cm in diameter in the middle. Each cover plate 400 has a second vent hole 410 with a diameter of 1 cm evenly punched at 1 cm intervals. The entire box body 100, partitions 200, partitions 300 and cover plates 400 are all made of 5 mm thick acrylic sheets, of which eight partitions 300 are white opaque acrylic sheets, while the box body 100, partitions 200 and cover plates 400 are all transparent acrylic sheets.
[0046] In the description of this specification, references to terms such as "some embodiments," "other embodiments," etc., indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.
[0047] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating the present utility model, and are not intended to limit the implementation of the present utility model. Those skilled in the art can make various obvious changes, readjustments, and substitutions without departing from the protection scope of this utility model. It is neither necessary nor possible to exhaustively describe all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.
Claims
1. A pressure modeling chamber for laboratory animals, characterized in that, include: The box body (100) has a receiving cavity; A partition (200) is installed on the box body (100) and divides the receiving cavity into a first cavity (101) and a second cavity, the second cavity being located radially outside the first cavity (101), the first cavity (101) being used to place a pressure stimulation source; Multiple partitions (300) are installed in the second cavity and divide the second cavity into multiple placement cavities (102). The multiple placement cavities (102) are evenly distributed along the circumference of the first cavity (101), and each placement cavity (102) is used to accommodate one experimental animal. Multiple cover plates (400) are detachably mounted on the box body (100), and the multiple cover plates (400) are correspondingly arranged with multiple receiving cavities; the partition (200) is detachably connected to the box body (100); wherein, a first slot is provided on one of the bottom walls of the partition (200) and the bottom wall of the box body (100), and a first insertion protrusion that mates with the first slot is provided on the other of the bottom walls of the partition (200) and the bottom wall of the box body (100).
2. The experimental animal pressure modeling chamber according to claim 1, characterized in that, There are multiple first slots, which are distributed circumferentially along the first cavity (101). There are multiple first insertion protrusions, which are arranged in a one-to-one correspondence with the multiple first slots.
3. The experimental animal pressure modeling chamber according to claim 1, characterized in that, The first end of each of the cover plates (400) engages with the top wall of the box body (100) via a hinge (500), and the second ends of the plurality of cover plates (400) enclose a receiving hole (420).
4. The experimental animal pressure modeling chamber according to claim 1, characterized in that, Of the two adjacent cover plates (400), one cover plate (400) has a locking protrusion and the other cover plate (400) has a locking groove. The two adjacent cover plates (400) are connected by the locking protrusion and the locking groove.
5. The experimental animal pressure modeling chamber according to claim 1, characterized in that, The inner sidewall of the box body (100) and / or the inner sidewall of the partition (200) are provided with mounting grooves, and the sidewall of the partition (300) is slidably installed in the mounting groove along the height direction of the box body (100).
6. The experimental animal pressure modeling chamber according to claim 1, characterized in that, A second slot is provided on one of the bottom walls of the partition (300) and the bottom wall of the box body (100), and a second insertion protrusion that mates with the second slot is provided on the other of the bottom walls of the partition (300) and the bottom wall of the box body (100).
7. The experimental animal pressure modeling chamber according to claim 1, characterized in that, The separator (200) is provided with a plurality of first vent holes (210), which are distributed at intervals along the circumference and axial direction of the separator (200).
8. The experimental animal pressure modeling chamber according to claim 1, characterized in that, The cover plate (400) is provided with a plurality of second vent holes (410), which are arranged in a circular array.
9. The experimental animal pressure modeling chamber according to claim 1, characterized in that, The partition (300) has at least one third vent hole (310) on its side wall.