Barometric organ-on-chip fluidic control device

Abstract

The application discloses a kind of barometric organ chip fluid control devices, it is related to cell or tissue culture technical field, including air pressure control module, gas distribution module, chip set card box and embedded control module;Air pressure control module output is connected with the input of gas distribution module, air pressure control module is used to inhale external gas, and the air pressure of gas output to gas distribution module is adjusted in real time;The output of gas distribution module is connected with chip set card box, and gas distribution module is used to divide the input gas into multiple, and multiple gas is input into chip set card box respectively;Chip set card box is used to store cell culture solution, and cell culture solution flows in chip set card box under the blowing of gas;Embedded control module is connected with air pressure control module, and embedded control module is used to send air pressure control instruction to air pressure control module.The above-mentioned barometric organ chip fluid control device increases the convenience of cell flow culture.

Description

Technical Field

[0001] This utility model relates to the field of cell or tissue culture technology, and more specifically to a pneumatic organ-on-a-chip fluid control device. Background Technology

[0002] The emergence of organ-on-a-chip technology has provided a new strategy for constructing human-derived biomimetic in vitro models. These models offer advantages such as precise fluid control, multi-cell co-culture, and tissue barrier simulation, enabling highly controllable reproduction of complex dynamic culture microenvironments and simulating the communication and cooperation of multiple organs, thus establishing a reliable platform for life science and medical research.

[0003] Dynamic culture devices are crucial tools for realizing organ-on-a-chip functionality. Existing organ-on-a-chip culture devices are mostly external mechanical pumps, characterized by low integration, poor compatibility, and the need for external tubing. This results in high operational difficulty and poor reproducibility, often limiting their use to laboratory settings and hindering large-scale fabrication or high-throughput applications. Therefore, from an application perspective, there is a need to develop more integrated and user-friendly organ-on-a-chip culture devices to reduce learning costs and increase culture throughput, thereby better meeting application requirements. Utility Model Content

[0004] The purpose of this invention is to provide a pneumatic organ-on-a-chip fluid control device that eliminates the need for an external air pump. The gas flow rate can be controlled through the pneumatic control module, simplifying the device and making it applicable to more scenarios. The gas distribution module ensures more uniform gas flow, improving cell culture quality. Furthermore, users can actively control the gas pressure using the embedded control module, increasing the device's controllability.

[0005] To achieve the above objectives, this utility model provides a pneumatic organ-on-a-chip fluid control device, which includes a pneumatic control module, a gas distribution module, a chipset cartridge, and an embedded control module.

[0006] The output of the pressure control module is connected to the input of the gas distribution module. The pressure control module is used to draw in external gas and adjust the pressure of the gas output to the gas distribution module in real time.

[0007] The output of the gas distribution module is connected to the chipset card box. The gas distribution module is used to divide the input gas into multiple portions and input the multiple portions of gas into the chipset card box respectively.

[0008] The chipset cartridge is used to store cell culture medium, which flows within the cartridge under the influence of gas.

[0009] The embedded control module is communicatively connected to the pneumatic control module, and the embedded control module is used to send pneumatic control commands to the pneumatic control module.

[0010] In another embodiment, the pressure control module includes an input port, a gas flow regulating valve, an integrated chip, and an output port;

[0011] The inlet is connected to the gas flow regulating valve via a gas pipeline, and the gas flow regulating valve is connected to the outlet via a gas pipeline. The gas flow regulating valve is also connected to the integrated chip for communication.

[0012] External gas enters the gas pipeline through the inlet, passes through the gas flow regulating valve, and is output from the outlet.

[0013] The integrated chip is used to send a gas pressure regulation command to the gas flow regulating valve, which is used to adjust the gas pressure of the gas output from the outlet according to the gas pressure regulation command.

[0014] In another embodiment, the gas distribution module includes two sets of solenoid valves and a solenoid valve mounting frame;

[0015] The solenoid valve includes one air inlet and six air outlets;

[0016] The air inlet is connected to the output port of the air pressure control module. The gas output from the output port enters the solenoid valve through the air inlet and is discharged from the six air outlets.

[0017] The solenoid valve mounting frame is used to secure two sets of solenoid valves.

[0018] In another embodiment, the chipset cartridge includes: a top cover, a culture medium chamber, a chip, and a bottom cover;

[0019] The top cover, culture medium chamber, chip, and bottom cover are connected sequentially by snap-fit ​​mechanisms.

[0020] The top cover has 12 air inlets, each corresponding to an air outlet of the solenoid valve.

[0021] The culture medium chamber is used to store cell culture medium. Gas enters the culture medium chamber through the air inlet, blowing the cell culture medium to move on the chip.

[0022] In another embodiment, the pneumatic organ-on-a-chip fluid control device further includes: a clamping mechanism;

[0023] The clamping mechanism is located between the gas distribution module and the chipset card holder, and is used to clamp the chipset card holder.

[0024] In another embodiment, the clamping mechanism includes a stepper motor, a belt, a lead screw, and a slider;

[0025] The stepper motor drives the belt to move through the gear on the motor shaft. The belt drives the lead screw to rotate through the lead screw gear. The lead screw drives the slider to move up and down to press or release the chipset card.

[0026] The slider is equipped with 12 sealing rings. The first end of each of the 12 sealing rings is connected to the air outlet of the solenoid valve, and the second end of each of the 12 sealing rings corresponds to one of the 12 air inlets on the chipset card box. When the clamping mechanism clamps the chipset card box, the second end of each of the 12 sealing rings is connected to the 12 air inlets on the chipset card box.

[0027] In another embodiment, the pneumatic organ-on-a-chip fluid control device further includes: a mounting mechanism;

[0028] The mounting mechanism is located below the chipset card holder and is used to mount the chipset card holder.

[0029] In another embodiment, the mounting mechanism includes a chip positioning base and a guide rail;

[0030] The chip positioning base is equipped with limit beads, which are used to restrict the chipset card box to a fixed position on the mounting mechanism;

[0031] The chip positioning base is mounted on the guide rail and can move along the length of the guide rail.

[0032] In another embodiment, the pneumatic organ-on-a-chip fluid control device further includes: an instrument base plate;

[0033] The guide rail is fixed to the instrument base plate and connected to the instrument base plate via wires;

[0034] The instrument base plate is also equipped with a latch and a positioning detection switch;

[0035] The positioning detection switch is used to control the latch to lock the chip positioning base when the chip positioning base moves to the preset position of the guide rail, and send the positioning signal to the embedded control module.

[0036] In another embodiment, the embedded control module includes: a touch screen, indicator lights, a control motherboard, a driver, and a power supply;

[0037] The power supply is used to power the pneumatic organ-on-a-chip fluid control device;

[0038] The touchscreen is used to receive relevant control commands;

[0039] The indicator light is used to indicate whether the chip positioning base is in a preset position based on the positioning signal;

[0040] The control board is used to send air pressure control commands to the air pressure control module and drive commands to the driver according to relevant control commands;

[0041] The driver is used to move the positioning base of the driving chip on the guide rail according to the driving instructions.

[0042] The beneficial effects of this utility model are as follows: The pneumatic organ-on-a-chip fluid control device of this utility model includes a pneumatic control module, a gas distribution module, a chipset cassette, and an embedded control module. The output end of the pneumatic control module is connected to the input end of the gas distribution module. The pneumatic control module is used to draw in external gas and adjust the gas pressure of the gas output to the gas distribution module in real time. The output end of the gas distribution module is connected to the chipset cassette. The gas distribution module is used to divide the input gas into multiple portions and input each portion of gas into the chipset cassette. The chipset cassette is used to store cell culture medium, which flows within the chipset cassette under the blowing of gas. The embedded control module is communicatively connected to the pneumatic control module and is used to send pneumatic control commands to the pneumatic control module. The device simplifies the process by eliminating the need for an external air pump and enabling gas flow rate control through the pneumatic control module. This makes the device applicable to more scenarios. Furthermore, the gas distribution module ensures more uniform gas flow, improving cell culture quality. Additionally, users can actively control the gas pressure using the embedded control module, increasing the controllability of the device.

[0043] The above description is only an overview of the technical solution of this utility model. In order to better understand the technical means of this utility model and to implement it in accordance with the contents of the specification, the preferred embodiments of this utility model are described in detail below with reference to the accompanying drawings. Attached Figure Description

[0044] Figure 1 This is a schematic diagram of the structure of a pneumatic organ-on-a-chip fluid control device according to an embodiment of this application;

[0045] Figure 2 This is a schematic diagram of the structure of a gas distribution module according to an embodiment of this application;

[0046] Figure 3 This is a schematic diagram of the structure of a chipset card holder according to an embodiment of this application;

[0047] Figure 4 This is a schematic diagram of a clamping mechanism according to an embodiment of this application;

[0048] Figure 5 This is a schematic diagram of the structure of a mounting mechanism according to an embodiment of this application;

[0049] Figure 6 This is a schematic diagram of the structure of an instrument base plate according to an embodiment of this application;

[0050] Figure 7This is a schematic diagram of the structure of an embedded control module according to an embodiment of this application;

[0051] Reference numerals: 1. Instrument base plate; 2. Gas pressure control module; 3. Gas distribution module; 4. Pressing mechanism; 5. Chipset card holder; 6. Mounting mechanism; 7. Embedded control module; 8. Housing; 311. Air inlet; 312. Solenoid valve; 313. Air outlet; 314. Solenoid valve fixing frame; 511. Top cover; 512. Culture medium chamber; 513. Chip; 514. Bottom cover; 411. Stepper motor; 412. Belt; 413. Lead screw; 414. Slider; 415. Sealing ring; 611. Chip positioning base; 612. Limiting ball; 613. Guide rail; 614. Lock; 615. Position detection switch; 616. Cable groove; 711. Touch screen; 712. Indicator light; 713. Control motherboard; 714. Driver; 715. Power supply. Detailed Implementation

[0052] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0053] It should be noted that references to "an embodiment," "embodiment," "example embodiment," etc., in this specification refer to the described embodiment including specific features, structures, or characteristics; however, not every embodiment must include these specific features, structures, or characteristics. Furthermore, such expressions do not refer to the same embodiment. Moreover, when describing specific features, structures, or characteristics in conjunction with embodiments, whether or not explicitly described, it is indicated that incorporating such features, structures, or characteristics into other embodiments is within the knowledge of those skilled in the art.

[0054] Furthermore, certain terms are used in the specification and subsequent claims to refer to specific components or parts. Those skilled in the art will understand that manufacturers may use different names or terms to refer to the same component or part. This specification and subsequent claims do not distinguish components or parts by differences in name, but rather by differences in function. The terms "comprising" and "including" used throughout the specification and subsequent claims are open-ended and should be interpreted as "including but not limited to." Additionally, the term "connection" here includes any direct and indirect electrical connection means. Indirect electrical connection means include connections made through other means.

[0055] Please see Figure 1 A schematic diagram of a pneumatic organ-on-a-chip fluid control device is provided. The pneumatic organ-on-a-chip fluid control device includes a pneumatic control module 2, a gas distribution module 3, a chip set card 5, and an embedded control module 7.

[0056] The output of the pressure control module 2 is connected to the input of the gas distribution module 3. The pressure control module 2 is used to draw in external gas and adjust the pressure of the gas output to the gas distribution module 3 in real time. The output of the gas distribution module 3 is connected to the chipset card box 5. The gas distribution module 3 is used to divide the input gas into multiple portions and input the multiple portions of gas into the chipset card box 5 respectively. The chipset card box 5 is used to store cell culture medium, which flows in the chipset card box 5 under the blowing of gas. The embedded control module 7 is communicatively connected to the pressure control module 2 and is used to send pressure control commands to the pressure control module 2.

[0057] Specifically, during the operation of the pneumatic organ-on-a-chip fluid control device, the pneumatic control module 2 draws in external gas and, under the control of the embedded control module 7, adjusts the gas pressure before outputting the gas to the gas distribution module 3. The gas distribution module 3 then distributes the obtained gas into multiple portions and blows them into the chip set cartridge 5, thereby agitating the cell culture medium in the chip set cartridge 5 and realizing dynamic cell culture.

[0058] Optionally, the pneumatic organ-on-a-chip fluid control device may also include a housing 8, which can make the entire interior of the pneumatic organ-on-a-chip fluid control device a sterile environment.

[0059] The pneumatic organ-on-a-chip fluid control device in the above embodiments includes a pneumatic control module 2, a gas distribution module 3, a chipset cartridge 5, and an embedded control module 7. The output end of the pneumatic control module 2 is connected to the input end of the gas distribution module 3. The pneumatic control module 2 is used to draw in external gas and adjust the gas pressure of the gas output to the gas distribution module 3 in real time. The output end of the gas distribution module 3 is connected to the chipset cartridge 5. The gas distribution module 3 is used to divide the input gas into multiple portions and input the multiple portions of gas into the chipset cartridge 5 respectively. The chipset cartridge 5 is used to store cell culture medium, which flows in the chipset cartridge 5 under the blowing of gas. The embedded control module 7 is communicatively connected to the pneumatic control module 2 and is used to send pneumatic control commands to the pneumatic control module 2. The device simplifies the process by eliminating the need for an external air pump and enabling gas flow rate control via the air pressure control module 2. This makes the device suitable for a wider range of scenarios. Furthermore, the gas distribution module 3 ensures more uniform gas flow, improving cell culture quality. Additionally, users can actively control the air pressure using the embedded control module 7, increasing the device's controllability.

[0060] In another embodiment, the air pressure control module 2 includes an input port, a gas flow regulating valve, an integrated chip, and an output port. The input port is connected to the gas flow regulating valve via a gas pipeline, and the gas flow regulating valve is connected to the output port via a gas pipeline. The gas flow regulating valve is also communicatively connected to the integrated chip. External gas enters the gas pipeline from the input port, passes through the gas flow regulating valve, and is output from the output port. The integrated chip is used to send air pressure regulation commands to the gas flow regulating valve, and the gas flow regulating valve is used to regulate the air pressure of the gas output from the output port according to the air pressure regulation commands.

[0061] Specifically, the embedded control module 7 communicates with the integrated chip. The embedded control module 7 can send air pressure control commands to the integrated chip, which then generates air pressure control commands based on the air pressure control commands and sends them to the gas flow regulating valve. This controls the gas flow regulating valve to adjust its size, thereby regulating the air pressure of the input gas. The gas enters from the input port, and after the air pressure is adjusted by the gas flow regulating valve, it is output from the output port.

[0062] Optionally, an air pump and a gas processor can be connected to the front end of the output port. After the air pump draws in air, the air is purified by the gas processor and then input from the input port of the air pressure control module 2.

[0063] In another embodiment, such as Figure 2 As shown, a schematic diagram of a gas distribution module is provided. The gas distribution module 3 includes two sets of solenoid valves 312 and a solenoid valve fixing frame 314. The solenoid valve 312 includes an air inlet 311 and six air outlets 313. The air inlet 311 is connected to the output port of the gas pressure control module 2. The gas output from the output port enters the solenoid valve 312 from the air inlet 311 and is discharged from the six air outlets 313. The solenoid valve fixing frame 314 is used to fix the two sets of solenoid valves 312.

[0064] Specifically, the solenoid valve fixing frame 314 fixes the solenoid valve 312 in a fixed position. The output port of the air pressure control module 2 is connected to the air inlet 311 of the solenoid valve 312. Gas enters the solenoid valve 312 through the air inlet 311 and is divided into 6 parts inside the solenoid valve 312 and discharged from the air outlet 313.

[0065] In another embodiment, such as Figure 3As shown, a schematic diagram of a chipset cartridge 5 is provided. The chipset cartridge 5 includes: an upper cover 511, a culture medium chamber 512, a chip 513, and a lower cover 514. The upper cover 511, the culture medium chamber 512, the chip 513, and the lower cover 514 are sequentially connected by snap-fit ​​connections. The upper cover 511 is provided with 12 air inlets, which correspond one-to-one with the air outlet 313 of the solenoid valve 312. The culture medium chamber 512 is used to store cell culture medium. Gas enters the culture medium chamber 512 through the air inlets, causing the cell culture medium to move on the chip 513.

[0066] Specifically, the upper cover 511, the culture medium chamber 512, the chip 513, and the lower cover 514 are sequentially connected by snap-fit ​​mechanisms, so that the culture medium chamber 512 forms a closed space. The upper cover 511 can be opened to place the cell culture medium into the culture medium chamber 512, and then the upper cover 511 can be closed. The upper cover 511 is provided with the same number of air inlets as the air outlets 313 of the solenoid valve 312. The gas output by the solenoid valve 312 can enter the culture medium chamber 512 through the air inlets, thereby blowing the cell culture medium to move on the chip 513.

[0067] In another embodiment, such as Figure 4 As shown, a structural schematic diagram of a clamping mechanism is provided. The pneumatic organ-on-a-chip fluid control device further includes: a clamping mechanism 4; the clamping mechanism 4 is disposed between the gas distribution module 3 and the chip set cartridge 5, and is used to clamp the chip set cartridge 5; the clamping mechanism 4 includes a stepper motor 411, a belt 412, a lead screw 413, and a slider 414; the stepper motor 411 drives the belt 412 to move through a gear on the motor shaft, and the belt 412 drives the lead screw 413 through a gear. 3. Rotation causes the lead screw 413 to move the slider 414 up and down to press or release the chipset card 5. The slider 414 is equipped with 12 sealing rings 415. The first end of the 12 sealing rings 415 is connected to the air outlet 313 of the solenoid valve 312, and the second end of the 12 sealing rings 415 corresponds to the 12 air inlets on the chipset card 5. When the pressing mechanism 4 presses the chipset card 5, the second end of the 12 sealing rings 415 is connected to the 12 air inlets on the chipset card 5.

[0068] Specifically, after the chipset cartridge 5 is assembled, cell culture medium leakage may occur due to insufficient tightness in the connection of various components. Therefore, a clamping mechanism 4 is needed to clamp the various components of the chip 513 cartridge assembly. The stepper motor 411 of the clamping mechanism 4 drives the belt 412 to move through the gear on the motor shaft. The belt 412 drives the lead screw 413 to rotate through the gear on the lead screw 413. The lead screw 413 drives the slider 414 to move up and down to clamp or release the chipset cartridge 5. In addition, the air outlet 313 of the solenoid valve 312 can be set on the sealing ring 415 of the clamping device. When the clamping device clamps the chipset cartridge 5, the sealing ring 415 is tightly connected to the air inlet on the upper cover 511 of the chipset cartridge 5, allowing gas to enter the chipset cartridge 5. In order to ensure that the sealing ring 415 and the air inlet on the upper cover 511 can be in tight contact, the material of the sealing ring 415 can be silicone.

[0069] It should be noted that the number of air outlets of the solenoid valve and the number of sealing rings are equal to the number of air inlets on the chipset card box, but the specific number can be adjusted according to actual usage requirements and is not necessarily fixed at 12 as stated in this application.

[0070] In another embodiment, such as Figure 5 As shown, a schematic diagram of a mounting mechanism is provided. The pneumatic organ-on-a-chip fluid control device further includes: a mounting mechanism 6; the mounting mechanism 6 is disposed below the chip set cartridge 5, and is used to mount the chip set cartridge 5; the mounting mechanism 6 includes a chip positioning base 611 and a guide rail 613; a limiting ball 612 is provided on the chip positioning base 611, and the limiting ball 612 is used to restrict the chip set cartridge 5 to a fixed position on the mounting mechanism 6; the chip positioning base 611 is mounted on the guide rail 613, and the chip positioning base 611 can move along the length direction of the guide rail 613.

[0071] Specifically, since the chipset cartridge 5 is located below the clamping mechanism 4, when the chipset cartridge 5 needs to be operated (such as changing the cell culture medium), the clamping mechanism 4 will release the chipset cartridge 5. At this time, the clamping mechanism 4 is still above the chipset cartridge 5. In order to facilitate operation, the chipset cartridge 5 needs to be moved out from below the clamping mechanism 4 through the guide rail 613. The limiting ball 612 can prevent the chipset cartridge 5 from moving on the mounting mechanism 6.

[0072] In another embodiment, such as Figure 6As shown, a schematic diagram of the structure of an instrument base plate is provided. The pneumatic organ-on-a-chip fluid control device further includes: an instrument base plate 1; a guide rail 613 fixed on the instrument base plate 1 and connected to the instrument base plate 1 via a wire; the instrument base plate 1 is also provided with a latch 614 and a position detection switch 615; the position detection switch 615 is used to control the latch 614 to lock the chip positioning base 611 when the chip positioning base 611 moves to a preset position on the guide rail 613, and send the position signal to the embedded control module 7.

[0073] Specifically, when the chip positioning base 611 moves to the preset position of the guide rail 613, it will block the position detection switch 615. At this time, the position detection switch 615 can detect that the chip positioning base 611 has reached the preset position. In order to fix the position of the chip set card box 5, the position detection switch 615 will control the latch 614 to lock the chip positioning base 611 and send the position signal to the embedded control module 7. Subsequently, the embedded control module 7 can control the gas to enter, thereby performing dynamic cell culture.

[0074] In another embodiment, such as Figure 7 As shown, a schematic diagram of an embedded control module is provided. The embedded control module 7 includes: a touch screen 711, an indicator light 712, a control motherboard 713, a driver 714, and a power supply 715. The power supply 715 is used to supply power to the pneumatic organ-on-a-chip fluid control device. The touch screen 711 is used to receive relevant control commands. The indicator light 712 is used to indicate whether the chip positioning base 611 is in a preset position based on the position signal. The control motherboard 713 is used to send pneumatic control commands to the pneumatic control module 2 and drive commands to the driver 714 according to the relevant control commands. The driver 714 is used to drive the chip positioning base 611 to move on the guide rail 613 according to the drive commands.

[0075] For example, when dynamic cell culture is required, the operator can control the clamping mechanism 4 to release the chipset cartridge 5 via the touch screen 711, and then control the chip positioning base 611 to move out from under the clamping mechanism 4 on the guide rail 613. After the cell culture medium is poured into the chipset cartridge 5, the operator can control the chip positioning base 611 to move on the guide rail 613 to a preset position. At this time, the position detection switch 615 detects that the chip positioning base 611 has reached the preset position. In order to fix the position of the chipset cartridge 5, the position detection switch 615 will control the latch 614 to lock the chip positioning base 611 and send the position signal to the indicator light 712. At this time, the operator can operate the touch screen 711 to send a pressure control command to the pressure control module 2, thereby performing dynamic cell culture.

[0076] Optionally, in order to drive the chip positioning base 611 to move on the guide rail 613, a wire needs to be set between the power supply 715 and the driver 714. Therefore, a wire groove 616 is also installed on the instrument base plate 1, and the wire can be placed in the wire groove 616 to prevent damage.

[0077] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0078] The above embodiments only illustrate several implementation methods of this utility model, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of the utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A pneumatic organ-on-a-chip fluid control device, characterized in that, The pneumatic organ-on-a-chip fluid control device includes a pneumatic control module, a gas distribution module, a chipset card box, and an embedded control module; The output of the pressure control module is connected to the input of the gas distribution module. The pressure control module is used to draw in external gas and adjust the pressure of the gas output to the gas distribution module in real time. The output of the gas distribution module is connected to the chipset card box. The gas distribution module is used to divide the input gas into multiple portions and input the multiple portions of gas into the chipset card box respectively. The chipset cartridge is used to store cell culture medium, which flows within the chipset cartridge under the influence of gas. The embedded control module is communicatively connected to the air pressure control module, and the embedded control module is used to send air pressure control commands to the air pressure control module.

2. The pneumatic organ-on-a-chip fluid control device as described in claim 1, characterized in that, The air pressure control module includes an input port, a gas flow regulating valve, an integrated chip, and an output port; The input port is connected to a gas flow regulating valve via a gas pipeline, the gas flow regulating valve is connected to the output port via a gas pipeline, and the gas flow regulating valve is also connected to the integrated chip in communication. External gas enters the gas pipeline from the inlet, passes through the gas flow regulating valve, and is output from the outlet. The integrated chip is used to send a pressure regulation command to the gas flow regulating valve, and the gas flow regulating valve is used to adjust the pressure of the gas output from the output port according to the pressure regulation command.

3. The pneumatic organ-on-a-chip fluid control device as described in claim 2, characterized in that, The gas distribution module includes two sets of solenoid valves and a solenoid valve fixing frame; The solenoid valve includes one air inlet and six air outlets; The air inlet is connected to the output port of the air pressure control module. The gas output from the output port enters the solenoid valve from the air inlet and is discharged from the six air outlets. The solenoid valve mounting frame is used to fix the two sets of solenoid valves.

4. The pneumatic organ-on-a-chip fluid control device as described in claim 3, characterized in that, The chipset cartridge includes: an upper cover, a culture medium chamber, a chip, and a lower cover; The upper cover, culture medium chamber, chip and lower cover are connected in sequence by snap-fit; The upper cover is provided with 12 air inlets, and each air inlet corresponds to an air outlet of the solenoid valve. The culture medium chamber is used to store cell culture medium. Gas enters the culture medium chamber through the air inlet and blows the cell culture medium to move on the chip.

5. The pneumatic organ-on-a-chip fluid control device as described in claim 4, characterized in that, The pneumatic organ-on-a-chip fluid control device further includes: a clamping mechanism; The clamping mechanism is disposed between the gas distribution module and the chipset card holder, and the clamping mechanism is used to clamp the chipset card holder.

6. The pneumatic organ-on-a-chip fluid control device as described in claim 5, characterized in that, The clamping mechanism includes a stepper motor, a belt, a lead screw, and a slider; The stepper motor drives the belt to move through the gear on the motor shaft. The belt drives the lead screw to rotate through the lead screw gear. The lead screw drives the slider to move up and down to press or release the chipset card box. The slider is provided with 12 sealing rings. The first end of the 12 sealing rings is connected to the air outlet of the solenoid valve, and the second end of the 12 sealing rings corresponds one-to-one with the 12 air inlets on the chipset card box. When the pressing mechanism presses the chipset card box, the second end of the 12 sealing rings is connected to the 12 air inlets on the chipset card box.

7. The pneumatic organ-on-a-chip fluid control device as described in claim 6, characterized in that, The pneumatic organ-on-a-chip fluid control device further includes: a mounting mechanism; The mounting mechanism is located below the chipset card box, and the mounting mechanism is used to mount the chipset card box.

8. The pneumatic organ-on-a-chip fluid control device as described in claim 7, characterized in that, The mounting mechanism includes a chip positioning base and a guide rail; The chip positioning base is provided with a limiting ball, which is used to restrict the chip set card box to a fixed position on the mounting mechanism; The chip positioning base is mounted on the guide rail, and the chip positioning base is capable of moving along the length of the guide rail.

9. The pneumatic organ-on-a-chip fluid control device as described in claim 8, characterized in that, The pneumatic organ-on-a-chip fluid control device also includes: an instrument base plate; The guide rail is fixed to the instrument base plate and connected to the instrument base plate via a wire. The instrument base plate is also equipped with a latch and a positioning detection switch; The positioning detection switch is used to control the latch to lock the chip positioning base when the chip positioning base moves to a preset position on the guide rail, and to send a positioning signal to the embedded control module.

10. The pneumatic organ-on-a-chip fluid control device as described in claim 9, characterized in that, The embedded control module includes: a touch screen, indicator lights, a control motherboard, a driver, and a power supply; The power source is used to supply power to the pneumatic organ-on-a-chip fluid control device. The touchscreen is used to receive relevant control commands; The indicator light is used to indicate whether the chip positioning base is in a preset position based on the positioning signal; The control motherboard is used to send air pressure control commands to the air pressure control module and drive commands to the driver according to the relevant control commands. The driver is used to drive the chip positioning base to move on the guide rail according to the driving command.

Images