A reduced pressure distillation apparatus for podophyllotoxin purification

Abstract

This utility model relates to the field of podophyllotoxin purification technology, specifically a vacuum distillation apparatus for podophyllotoxin purification. It includes a base plate, a heating device and a vacuum pump mounted above the base plate, a distillation assembly inside the heating device, and a distillation flask. A stirring assembly is also located inside the heating device, comprising a cross plate fixedly installed on the lower inner surface of the distillation flask, and multiple stirring rods fixedly installed at equal angles at the lower outer surface of the distillation flask. A condensation assembly is located on one side of the vacuum pump. In this utility model, the rotation of the distillation flask creates a centripetal vortex within the flask, increasing the contact area between the solution and the flask, accelerating the evaporation rate. Simultaneously, the rotation of the distillation flask drives the multiple stirring rods on the outside to rotate, agitating the water inside the heating device. This ensures even heat distribution in the water, preventing localized overheating due to uneven heat distribution and improving the stability during purification.

Description

Technical Field

[0001] This utility model relates to the field of podophyllotoxin purification technology, specifically a vacuum distillation apparatus for purifying podophyllotoxin. Background Technology

[0002] In the purification of podophyllotoxin, a vacuum distillation apparatus is often necessary, especially when solvent recovery, concentration of extracts, or preliminary purification steps are involved.

[0003] In the extraction of podophyllotoxin, a heating device is usually used to heat the distillation flask, and then a vacuum pump is used to reduce the pressure in the rectified environment, so that the solution can be concentrated into a large amount of solvent more quickly by vacuum distillation. However, when heating the distillation flask, because water is used for heating, the heating device will cause temperature differences in different parts of the water inside. When the heat is transferred to the distillation flask, it is easy to cause local overheating of the solution, which will affect the purity, yield and biological activity of the product. In addition, the heat is transferred from the distillation flask to the inside of the solution, and the heated area of ​​the solution is small, resulting in a slow evaporation rate. Utility Model Content

[0004] The purpose of this invention is to provide a vacuum distillation apparatus for purifying podophyllotoxin, so as to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A vacuum distillation apparatus for purifying podophyllotoxin includes:

[0007] A base plate, on which a heating device and an air pump are installed;

[0008] A distillation assembly is disposed inside a heating device. The distillation assembly includes a distillation flask, a fixed sleeve is fixedly installed on the upper end of the distillation flask, an outlet pipe is fixedly inserted inside the fixed sleeve, and a rotary joint is fixedly inserted on the upper end of the outlet pipe.

[0009] A stirring assembly is disposed inside the heating device. The stirring assembly includes a cross plate fixedly installed on the lower surface of the inside of the distillation flask, and multiple stirring rods fixedly installed at equal angles at the lower end of the outer surface of the distillation flask.

[0010] The condenser assembly is located on the side of the air pump.

[0011] Furthermore, a feed pipe is fixedly connected to the outer surface of the distillation flask, a support frame is fixedly installed at the upper end of the heating device, and the fixed sleeve is rotatably connected to the support frame through a bearing.

[0012] Preferably, a motor is fixedly mounted on the upper surface of the support frame, and two meshing gears are fixedly mounted on the output end of the motor and the outer surface of the fixed sleeve.

[0013] Furthermore, a three-way tube is fixedly inserted into the upper end of the rotary joint, a thermometer is fixedly inserted into one end of the three-way tube, and a support rod is fixedly installed at the bottom of the distillation flask.

[0014] Preferably, the condensation assembly includes:

[0015] The condenser tube is fixedly inserted into the other end of the tee tube;

[0016] A spiral tube is fixedly wound around the outer surface of the condenser tube;

[0017] The collection bottle is placed above the base plate and is movably connected to one end of the condenser tube.

[0018] Preferably, the upper end of the collection bottle is connected to a suction pipe, which is connected to a suction pump via a flexible tube, and the connection between the spiral tube and the condenser tube is filled with thermally conductive silicone.

[0019] Preferably, a heat-conducting pipe is fixedly inserted inside the condenser tube, and multiple heat dissipation fins are provided on the outer surface of the heat-conducting pipe. Both ends of the heat-conducting pipe and the spiral tube are fixedly connected by connecting pipes.

[0020] Compared with the prior art, the beneficial effects of this utility model are:

[0021] 1. The motor drives the gears to rotate the distillation flask, which in turn rotates the internal cross plate. This creates a centripetal vortex in the solution inside the flask, increasing the contact area between the solution and the flask, accelerating the evaporation rate. Simultaneously, the solution is stirred, ensuring even heat distribution. The rotation of the flask also drives multiple external stirring rods, agitating the water inside the heating device and ensuring even heat distribution. This prevents uneven heat distribution and localized overheating of the solution, thereby improving the stability during purification.

[0022] 2. The evaporated gas enters the condenser tube. The spiral tube and heat conduction tube are connected to low-temperature water through the connecting pipe. The low-temperature water flows through the spiral tube and heat conduction tube. The heat dissipation fins increase the heat exchange area of ​​the evaporated gas, causing the gas to condense into liquid and drip into the collection bottle, thereby increasing the condensation rate and accelerating the evaporation rate of the solution. Attached Figure Description

[0023] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0024] Figure 2 This is a schematic diagram of the vertical cross-sectional structure of the condenser assembly in this utility model;

[0025] Figure 3 This is a schematic diagram of the overall structure of the spiral tube and heat pipe in this utility model;

[0026] Figure 4 This is a schematic diagram of the internal structure of the heating device in this utility model;

[0027] Figure 5 This is a schematic diagram of the vertical cross-sectional structure of the distillation assembly and the stirring assembly in this utility model.

[0028] In the diagram: 1. Base plate; 101. Heating device; 102. Vacuum pump; 2. Distillation assembly; 201. Support frame; 202. Fixing sleeve; 203. Distillation flask; 204. Gas outlet pipe; 205. Feed pipe; 206. Rotary joint; 207. T-joint; 208. Thermometer; 3. Stirring assembly; 301. Cross plate; 302. Stirring rod; 303. Motor; 304. Gear; 305. Support rod; 4. Condensation assembly; 401. Condenser tube; 402. Spiral tube; 403. Heat conduction tube; 404. Heat dissipation fins; 405. Connecting pipe; 406. Collection bottle; 407. Vacuum pump. Detailed Implementation

[0029] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0030] Please see Figure 1-5 In this embodiment of the present invention, a vacuum distillation apparatus for purifying podophyllotoxin includes a base plate 1. A heating device 101 and a vacuum pump 102 are arranged above the base plate 1. Water is injected into the heating device 101 and heated to heat the distillation flask 203. The vacuum pump 102 operates to reduce the pressure of the purification environment by drawing in air. A distillation assembly 2 is arranged inside the heating device 101. The distillation assembly 2 includes a distillation flask 203. A fixing sleeve 202 is fixedly installed on the upper end of the distillation flask 203. An outlet pipe 204 is fixedly inserted inside the fixing sleeve 202. A rotary joint 206 is fixedly inserted on the upper end of the outlet pipe 204. A stirring assembly 3 is arranged inside the heating device 101. The stirring assembly 3 includes a cross plate 301 fixedly installed on the lower surface of the distillation flask 203. Multiple stirring rods 302 are fixedly installed at equal angles on the lower end of the outer surface of the distillation flask 203. A condensation assembly 4 is arranged on one side of the vacuum pump 102.

[0031] Specifically, the stirring component 3 drives the distillation flask 203 to rotate, causing the solution to form a centripetal vortex inside the distillation flask 203, increasing the contact area between the solution and the distillation flask 203. At the same time, it stirs the water inside the heating device 101, so that the heat in the water is evenly distributed. The steam is condensed by the condensing component 4, so that the purified solution drips into the collection bottle 406.

[0032] Example 1

[0033] like Figure 4 and Figure 5 As shown, in this embodiment, a feed pipe 205 is fixedly connected to the outer surface of the distillation flask 203, a support frame 201 is fixedly installed on the upper end of the heating device 101, and a fixed sleeve 202 is rotatably connected to the support frame 201 through a bearing, so that the fixed sleeve 202 can drive the distillation flask 203 to rotate freely; a three-way pipe 207 is fixedly inserted into the upper end of the rotary joint 206, and a thermometer 208 is fixedly inserted into one end of the three-way pipe 207; a support rod 305 is fixedly installed at the bottom of the distillation flask 203, and the support rod 305 abuts against the bottom of the heating device 101 to provide auxiliary support for the distillation flask 203.

[0034] In this embodiment, the support frame 201 is used to fix the distillation flask 203. When the distillation flask 203 rotates, one end of the rotary joint 206 rotates accordingly, and the other end is fixed to the bracket of the motor 303, so that when the distillation flask 203 rotates, the gas can still enter the three-way tube 207 and the temperature of the gas can be observed by the thermometer 208.

[0035] like Figure 5 As shown, in this embodiment, a motor 303 is fixedly mounted on the upper surface of the support frame 201, and two meshing gears 304 are fixedly mounted on the output end of the motor 303 and the outer surface of the fixed sleeve 202.

[0036] In practice, the motor 303 operates, and through the transmission of the gear 304, the distillation flask 203 rotates. The internal cross plate 301 rotates, causing the solution to form a centripetal vortex inside the distillation flask 203, increasing the contact area between the solution and the distillation flask 203, accelerating the evaporation rate of the solution, and simultaneously stirring the solution to ensure uniform heat distribution. When the distillation flask 203 rotates, it drives the multiple stirring rods 302 on the outside to rotate, stirring the water inside the heating device 101 to ensure uniform heat distribution in the water, avoiding local overheating of the solution due to uneven heat distribution, thereby improving the stability during purification.

[0037] like Figure 2 and Figure 3As shown, in this embodiment, the condensation assembly 4 includes: a condenser tube 401 fixedly inserted into the other end of the three-way tube 207; a spiral tube 402 fixedly wound around the outer surface of the condenser tube 401; a collection bottle 406 placed above the base plate 1 and movably inserted into one end of the condenser tube 401; a suction pipe 407 is inserted into the upper end of the collection bottle 406, and the suction pipe 407 is connected to the suction pump 102 through a flexible hose; the connection between the spiral tube 402 and the condenser tube 401 is filled with thermally conductive silicone, which increases the contact area between the spiral tube 402 and the condenser tube 401 and accelerates the heat conduction speed.

[0038] In practice, the evaporated gas enters the condenser tube 401, and the spiral tube 402 is connected to low-temperature water through the connecting pipe 405. The low-temperature water flows through the spiral tube 402 to cool the condenser tube 401, causing the gas to condense into liquid and drip into the collection bottle 406.

[0039] Example 2

[0040] Based on Example 1, in order to compensate for the problem that the heat conduction of gas from the outside by the condenser tube 401 is slow.

[0041] like Figure 3 As shown, in this embodiment, a heat pipe 403 is fixedly inserted inside the condenser tube 401, and multiple heat dissipation fins 404 are provided on the outer surface of the heat pipe 403. The heat pipe 403 and the spiral tube 402 are fixedly connected at both ends by a connecting pipe 405.

[0042] In practice, the heat pipe 403 passes through the inside of the condenser 401, and the low-temperature water flows through the heat pipe 403 to cool the heat dissipation fins 404, thereby increasing the heat exchange area of ​​the evaporating gas, improving the condensation rate, and accelerating the evaporation rate of the solution.

[0043] It will be apparent to those skilled in the art that this invention is not limited to the details of the exemplary embodiments described above, and that it can be implemented in other specific forms without departing from the spirit or essential characteristics of this invention. Therefore, the embodiments should be considered illustrative and non-limiting in all respects, and the scope of this invention is defined by the appended claims rather than the foregoing description. Thus, it is intended that all variations falling within the meaning and scope of equivalents of the claims be included within this invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0044] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A vacuum distillation apparatus for purifying podophyllotoxin, characterized in that, include: A base plate (1) is provided with a heating device (101) and an air pump (102) above the base plate (1). Distillation assembly (2) is located inside heating device (101). The distillation assembly (2) includes a distillation flask (203). A fixing sleeve (202) is fixedly installed on the upper end of the distillation flask (203). An outlet pipe (204) is fixedly inserted inside the fixing sleeve (202). A rotary joint (206) is fixedly inserted on the upper end of the outlet pipe (204). The stirring assembly (3) is located inside the heating device (101). The stirring assembly (3) includes a cross plate (301) fixedly installed on the lower surface of the inside of the distillation flask (203). Multiple stirring rods (302) are fixedly installed at equal angles at the lower end of the outer surface of the distillation flask (203). The condenser assembly (4) is located on one side of the air pump (102).

2. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 1, characterized in that, The outer surface of the distillation flask (203) is fixedly connected to the feed pipe (205), and the upper end of the heating device (101) is fixedly installed with a support frame (201). The fixing sleeve (202) is rotatably connected to the support frame (201) through a bearing.

3. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 2, characterized in that, The upper surface of the support frame (201) is fixedly mounted with a motor (303), and two meshing gears (304) are fixedly mounted on the output end of the motor (303) and the outer surface of the fixed sleeve (202).

4. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 1, characterized in that, A three-way tube (207) is fixedly inserted into the upper end of the rotary joint (206), a thermometer (208) is fixedly inserted into one end of the three-way tube (207), and a support rod (305) is fixedly installed at the bottom of the distillation flask (203).

5. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 4, characterized in that, The condensation assembly (4) includes: The condenser tube (401) is fixedly inserted into the other end of the tee tube (207); A spiral tube (402) is fixedly wound around the outer surface of the condenser tube (401); The collection bottle (406) is placed above the base plate (1) and is movably connected to one end of the condenser tube (401).

6. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 5, characterized in that, The upper end of the collection bottle (406) is connected to a suction pipe (407), which is connected to the suction pump (102) through a flexible tube. The connection between the spiral tube (402) and the condenser tube (401) is filled with thermally conductive silicone.

7. The vacuum distillation apparatus for purifying podophyllotoxin according to claim 5, characterized in that, A heat-conducting pipe (403) is fixedly inserted inside the condenser (401). Multiple heat dissipation fins (404) are provided on the outer surface of the heat-conducting pipe (403). Both ends of the heat-conducting pipe (403) and the spiral pipe (402) are fixedly connected by a connecting pipe (405).

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