A sample loading device for a high output crystallization system

Abstract

The utility model discloses a kind of sample adding devices for high-output crystallization system, comprising: workbench, multiple-channel tray is equipped in the middle part of workbench, multiple-channel tray is equipped with multiple test tube grooves, multiple-channel tray both sides are equipped with solid sample pool and liquid sample pool, solid sample pool is equipped between multiple-channel tray and solid sample pool, and solid sample moving rotating seat is equipped, connecting rod and weighing spoon are sequentially connected in solid sample moving rotating seat output end, and beam arm type sensor is equipped in weighing spoon;Liquid sample moving rotating seat is equipped between multiple-channel tray and liquid sample pool, liquid sample moving rotating seat output end is connected with liquid sample connecting plate, and multiple-channel tray is corresponded with multiple-channel tray with multiple liquid sample connecting plate interval installation pipettor;The technical problem that the design of traditional sample adding device is often relatively dispersed, inconvenient integration and management is solved by the above design.

Description

Technical Field

[0001] This utility model relates to the field of drug sample addition technology, specifically a sample addition device for a high-output crystallization system. Background Technology

[0002] High-output crystallization systems, in addition to their basic crystallization function, can also be used for crystallization process development and optimization, solving crystallization challenges, monitoring crystal habit changes, screening polymorphs / solvates / hydrates, and drug cocrystallization research. These functions make high-output crystallization systems widely applicable in drug development, materials science, and other fields. However, traditional sample addition devices in high-output crystallization system applications often suffer from cumbersome operation and low efficiency. These devices typically require frequent manual addition of raw materials, increasing labor intensity and affecting the continuity and stability of the production line.

[0003] Furthermore, traditional sample addition devices are often designed in a decentralized manner, making integration and management difficult and further reducing the efficiency of equipment application. In order to improve the production efficiency and automation level of chemical crystallization processes, there is an urgent need for a new type of sample addition device that can simplify the operation process, improve sample addition accuracy and continuity. Utility Model Content

[0004] This invention provides a sample addition device for a high-output crystallization system. The purpose is to achieve rapid and accurate addition of raw materials through integrated design, thereby improving the operating efficiency and production benefits of the entire crystallization system.

[0005] To achieve the above objectives, this utility model provides the following technical solution:

[0006] A sample loading device for a high-output crystallization system includes: a workbench, a multi-channel tray in the middle of the workbench, multiple test tube slots on the multi-channel tray, solid sample cells and liquid sample cells on both sides of the multi-channel tray, a solid sample moving rotating seat between the multi-channel tray and the solid sample cells, a solid sample moving rotating seat output end connected to a solid sample connecting plate, multiple solid sample rotating motors installed at intervals on the solid sample connecting plate, the output ends of the solid sample rotating motors being horizontally set and sequentially connected to a connecting rod and a weighing spoon, and a beam arm type sensor being installed inside the weighing spoon;

[0007] A liquid sample moving rotating seat is provided between the multi-channel tray and the liquid sample cell. The output end of the liquid sample moving rotating seat is connected to a liquid sample connecting plate. Multiple pipettes corresponding to the multi-channel tray are installed at intervals on the liquid sample connecting plate.

[0008] Each of the test tubes is equipped with a positioning laser at its center, the solid sample cell is equipped with a solid sample positioning laser at its center, and the liquid sample cell is equipped with a liquid sample positioning laser at its center.

[0009] Preferably, the solid sample moving rotary seat includes a first seat body, a first rotary motor is provided in the first seat body, the output end of the first rotary motor is vertically upward and connected to a solid sample loading plate, a first linear motion module is fixed at the bottom of the solid sample loading plate, a solid sample telescopic rod is fixed on the moving plate of the first linear motion module, and a solid sample connecting plate is vertically downward at the output end of the solid sample telescopic rod.

[0010] Preferably, the liquid sample moving rotary seat includes a second seat body, a second rotary motor is provided in the second seat body, the output end of the second rotary motor is vertically upward and connected to a liquid sample loading plate, a second linear motion module is fixed at the bottom of the liquid sample loading plate, a liquid sample telescopic rod is fixed on the moving plate of the second linear motion module, and the output end of the liquid sample telescopic rod is vertically downward and connected to a liquid sample connecting plate.

[0011] Preferably, the first housing contains a first microprocessor and a first analog-to-digital converter electrically connected to the first microprocessor. The input end of the first analog-to-digital converter is electrically connected to the beam arm sensor, the sample positioning laser, and the positioning laser inside the weighing spoon. The output end of the first microprocessor is electrically connected to the first rotary motor, the first linear motion module, the sample telescopic rod, and the sample rotary motor. The outer wall of the first housing contains a first touch screen electrically connected to the first microprocessor for controlling the sampling amount and the amount of sample added by the weighing spoon.

[0012] Preferably, the second housing contains a second microprocessor and a second analog-to-digital converter electrically connected to the second microprocessor. The input end of the second analog-to-digital converter is electrically connected to a positioning laser and a liquid sample positioning laser. The output end of the second microprocessor is electrically connected to a pipette, a second rotary motor, a second linear motion module, and a liquid sample telescopic rod. The outer wall of the second housing contains a second touch screen electrically connected to the second microprocessor for controlling the sample volume and the amount of sample added by the pipette.

[0013] Preferably, the connecting rod is S-shaped.

[0014] Preferably, the workbench, multi-channel tray, solid sample cell, and liquid sample cell are made of polycarbonate.

[0015] Preferably, the output end of the solid sample rotary motor is horizontally positioned and connected to a geared motor, and the geared motor is sequentially connected to a connecting rod and a weighing spoon.

[0016] Preferably, the output end of the first rotary motor is vertically upward and connected to a first geared motor, and the output end of the first geared motor is connected to a fixed sample plate.

[0017] Preferably, the output end of the second rotary motor is vertically upward and connected to a second geared motor, and the output end of the second geared motor is a liquid sample loading plate.

[0018] Compared with the prior art, the beneficial effects of this utility model are:

[0019] An integrated sample addition device for high-output crystallization systems is provided, enabling rapid and accurate addition of raw materials, thereby improving the overall operating efficiency and production benefits of the crystallization system. With the assistance of a beam-arm sensor, the sampling and addition volume of the weighing spoon is controlled via a first touchscreen display; with the assistance of a positioning laser, the sampling and addition volume of the pipette is controlled via a second touchscreen display, achieving automated operation of precisely adding predetermined amounts of solid solute and liquid solvent to sample vials using the weighing spoon and pipette. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0021] Figure 2 This is a schematic diagram of the fixed sample moving and rotating seat and the fixed sample moving and rotating seat structure of this utility model.

[0022] In the diagram: 1. Workbench; 2. Multi-channel tray; 21. Test tube trough; 3. Solid sample cell; 4. Liquid sample cell; 5. Solid sample moving rotary seat; 51. Solid sample connecting plate; 52. Solid sample rotary motor; 53. Connecting rod; 54. Weighing spoon; 55. First seat; 56. Solid sample loading plate; 57. First linear motion module; 58. Solid sample telescopic rod; 59. First touch screen display; 6. Liquid sample moving rotary seat; 61. Liquid sample connecting plate; 62. Pipette; 63. Second seat; 64. Liquid sample loading plate; 65. Second linear motion module; 66. Liquid sample telescopic rod; 68. Second touch screen display; 7. Positioning laser; 71. Solid sample positioning laser; 72. Liquid sample positioning laser. Detailed Implementation

[0023] A preferred embodiment of the present invention will now be described in conjunction with the accompanying drawings, providing a clear and complete description of the technical solution in this preferred embodiment.

[0024] A sample feeding device for a high-output crystallization system includes: a workbench 1, a multi-channel tray 2 in the middle of the workbench 1, multiple test tube slots 21 on the multi-channel tray 2, solid sample cells 3 and liquid sample cells 4 on both sides of the multi-channel tray 2, a solid sample moving rotating seat 5 between the multi-channel tray 2 and the solid sample cells 3, a solid sample connecting plate 51 connected to the output end of the solid sample moving rotating seat 5, multiple solid sample rotating motors 52 installed at intervals on the solid sample connecting plate 51, the output ends of the solid sample rotating motors 52 are horizontally set and connected in sequence to a connecting rod 53 and a weighing spoon 54, and a beam arm type sensor is installed inside the weighing spoon 54;

[0025] A liquid sample moving rotating seat 6 is provided between the multi-channel tray 2 and the liquid sample cell 4. The output end of the liquid sample moving rotating seat 6 is connected to a liquid sample connecting plate 61. Multiple pipettes 62 corresponding to the multi-channel tray 2 are installed at intervals on the liquid sample connecting plate 61.

[0026] A positioning laser 7 is provided at the center of each of the test tube tanks 21 and the center of each of the liquid sample pools 4.

[0027] Through the above design, the multi-channel tray 2 is a four-row, four-column tray, in which the solute and solvent to be loaded are placed in the solid sample cell 3 and the liquid sample cell 4, respectively. The sample vials of the high-output crystallization system are placed in the sixteen test tube slots 21 of the multi-channel tray 2.

[0028] The solid sample moving rotary seat 5's solid sample rotation motor 52 drives the connecting rod 53 and the weighing spoon 54 to rotate slightly clockwise or counterclockwise, thereby causing the weighing spoon 54 to scoop solute from the solid sample cell 3. The weighing spoon 54 has a built-in beam-arm sensor for weighing the solute, which is electrically connected to the first touch screen 59. The first touch screen 59 displays the mass value of the solute in the weighing spoon 54. After the operator adjusts the solute to the set mass, the solid sample moving rotary seat 5 drives the weighing spoon 54 to add solute to the sample bottles in the first to fourth rows of the multi-channel tray 2 in sequence. After the solid sample is added, the solid sample moving rotary seat 5 drives the weighing spoon 54 to automatically rotate above the solid sample cell 3. Then, the liquid sample moving rotary seat 6 drives multiple pipettes 62 to start weighing the liquid sample cell 4 according to the set solvent mass. After weighing, the liquid sample is added to the sample bottles in the first to fourth rows of the multi-channel tray 2 in sequence. After the liquid sample is added, the liquid sample moving rotating seat 6 drives the pipette 62 to automatically rotate above the liquid sample cell 4. Finally, the sixteen sample vials on the multi-channel tray 2 are removed one by one and placed in the high-output crystallization system to begin testing.

[0029] Specifically, the fixed sample moving rotating seat 5 includes a first seat body 55, a first rotating motor is provided inside the first seat body 55, the output end of the first rotating motor is vertically upward and connected to a fixed sample loading plate 56, a first linear motion module 57 is fixed at the bottom of the fixed sample loading plate 56, a fixed sample telescopic rod 58 is fixed on the moving plate of the first linear motion module 57, and the output end of the fixed sample telescopic rod 58 is vertically downward and connected to a fixed sample connecting plate 51.

[0030] Through the above design, the output end of the first rotary motor is connected to the first reduction motor to drive the sample loading plate 56 to rotate 180 degrees. The first linear motion module 57 at the bottom of the sample loading plate 56 drives the weighing spoon 54 to move horizontally in a linear motion, and the sample telescopic rod 58 drives the weighing spoon 54 to move vertically in a linear motion.

[0031] Specifically, the liquid sample moving rotating seat 6 includes a second seat body 63, a second rotating motor is provided inside the second seat body 63, the output end of the second rotating motor is vertically upward and connected to a liquid sample loading plate 64, a second linear motion module 65 is fixed at the bottom of the liquid sample loading plate 64, a liquid sample telescopic rod 66 is fixed on the moving plate of the second linear motion module 65, and the output end of the liquid sample telescopic rod 66 is vertically downward and connected to a liquid sample connecting plate 61.

[0032] Through the above design, the output end of the second rotary motor is connected to the second reduction motor to drive the liquid sample loading plate 64 to rotate 180 degrees. The second linear motion module 65 at the bottom of the liquid sample loading plate 64 drives the pipette 62 to move horizontally in a linear motion, and the liquid sample telescopic rod 66 drives the pipette 62 to move vertically in a linear motion.

[0033] Specifically, the first base 55 is provided with a first microprocessor and a first analog-to-digital converter electrically connected to the first microprocessor. The input end of the first analog-to-digital converter is electrically connected to the beam arm sensor, the sample positioning laser 71 and the positioning laser 7 inside the weighing spoon 54. The output end of the first microprocessor is electrically connected to the first rotary motor, the first linear motion module 57, the sample telescopic rod 58 and the sample rotary motor 52. The outer wall of the first base 55 is provided with a first touch screen 59 electrically connected to the first microprocessor, which is used to control the sampling amount and the sample addition amount of the weighing spoon 54.

[0034] Through the above design, the beam-arm sensor inside the weighing spoon 54 generates an electrical signal through deformation and sends the signal to the first analog-to-digital converter (ADC). The ADC amplifies the signal and converts it into a digital signal. The first microprocessor receives the digital signal, processes it according to a preset program, and finally calculates the weight of the solute, which is then displayed on the first touch screen 59. Simultaneously, the sample positioning laser 71 and the positioning laser 7 send the position information of the weighing spoon 54 to the first ADC. The ADC then sends the position information to the first microprocessor, which processes it according to a preset program to ultimately control the sampling and dispensing amounts of the weighing spoon 54.

[0035] Specifically, the second base 63 is provided with a second microprocessor and a second analog-to-digital converter electrically connected to the second microprocessor. The input end of the second analog-to-digital converter is electrically connected to the positioning laser 7 and the liquid sample positioning laser 72. The output end of the second microprocessor is electrically connected to the pipette 62, the second rotary motor, the second linear motion module 65 and the liquid sample telescopic rod 66. The outer wall of the second base 63 is provided with a second touch screen 68 electrically connected to the second microprocessor for controlling the sampling volume and the amount of sample added by the pipette 62.

[0036] Through the above design, the positioning laser 7 sends the position information of the pipette 62 to the second analog-to-digital converter in the form of an electrical signal. The second analog-to-digital converter amplifies the electrical signal and converts the amplified electrical signal into a digital signal. After receiving the digital signal, the second microprocessor processes it according to the preset program and finally controls the sampling volume and the amount of sample added by the pipette 62.

[0037] Specifically, the connecting rod 53 is S-shaped.

[0038] Specifically, the workbench 1, multi-channel tray 2, solid sample cell 3, and liquid sample cell 4 are made of polycarbonate.

[0039] Through the above design, the polycarbonate material is transparent, which facilitates positioning and replacement of solutes and solvents.

[0040] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A sample feeding device for a high-output crystallization system, characterized in that, include: The workbench (1) has a multi-channel tray (2) in the middle, and multiple test tube troughs (21) are provided on the multi-channel tray (2). Solid sample pools (3) and liquid sample pools (4) are provided on both sides of the multi-channel tray (2). A solid sample moving rotating seat (5) is provided between the multi-channel tray (2) and the solid sample pool (3). A solid sample connecting plate (51) is connected to the output end of the solid sample moving rotating seat (5). Multiple solid sample rotating motors (52) are installed at intervals on the solid sample connecting plate (51). The output end of the solid sample rotating motor (52) is horizontally set and connected to a connecting rod (53) and a weighing spoon (54) in sequence. A beam arm sensor is provided inside the weighing spoon (54). A liquid sample moving rotating seat (6) is provided between the multi-channel tray (2) and the liquid sample cell (4). The output end of the liquid sample moving rotating seat (6) is connected to a liquid sample connecting plate (61). Multiple pipettes (62) corresponding to the multi-channel tray (2) are installed at intervals on the liquid sample connecting plate (61). Each of the test tubes (21) is provided with a positioning laser (7) at its center, the solid sample cell (3) is provided with a solid sample positioning laser (71) at its center, and the liquid sample cell (4) is provided with a liquid sample positioning laser (72) at its center. The solid sample moving rotating seat (5) includes a first seat body (55), which is provided with a first microprocessor and a first analog-to-digital converter electrically connected to the first microprocessor. The input end of the first analog-to-digital converter is electrically connected to the beam arm sensor, solid sample positioning laser (71) and positioning laser (7) in the weighing spoon (54). The output end of the first microprocessor is electrically connected to the first rotary motor, the first linear motion module (57), the solid sample telescopic rod (58) and the solid sample rotary motor (52). The outer wall of the first seat body (55) is provided with a first touch screen (59) electrically connected to the first microprocessor, which is used to control the sampling amount and the amount of sample added by the weighing spoon (54). The beam arm sensor is electrically connected to the first touch screen (59). The first touch screen (59) displays the mass value of the solute in the weighing spoon (54). After adjusting the solute to the set mass, the solid sample moving rotating seat (5) drives the weighing spoon (54) to add solute to the sample bottles in the first to fourth rows of the multi-channel tray (2) in sequence.

2. The sample feeding device for a high-output crystallization system according to claim 1, characterized in that: The first base (55) is equipped with a first rotary motor. The output end of the first rotary motor is vertically upward and connected to a sample loading plate (56). The bottom of the sample loading plate (56) is fixed with a first linear motion module (57). The moving plate of the first linear motion module (57) is fixed with a sample telescopic rod (58). The output end of the sample telescopic rod (58) is vertically downward and connected to a sample connecting plate (51).

3. The sample feeding device for a high-output crystallization system according to claim 1, characterized in that: The liquid sample moving rotating seat (6) includes a second seat body (63), a second rotating motor is provided inside the second seat body (63), the output end of the second rotating motor is vertically upward and connected to a liquid sample loading plate (64), a second linear motion module (65) is fixed at the bottom of the liquid sample loading plate (64), a liquid sample telescopic rod (66) is fixed on the moving plate of the second linear motion module (65), and the output end of the liquid sample telescopic rod (66) is vertically downward and connected to a liquid sample connecting plate (61).

4. The sample feeding device for a high-output crystallization system according to claim 3, characterized in that: The second base (63) is provided with a second microprocessor and a second analog-to-digital converter electrically connected to the second microprocessor. The input end of the second analog-to-digital converter is electrically connected to the positioning laser (7) and the liquid sample positioning laser (72). The output end of the second microprocessor is electrically connected to the pipette (62), the second rotary motor, the second linear motion module (65), and the liquid sample telescopic rod (66). The outer wall of the second base (63) is provided with a second touch screen (68) electrically connected to the second microprocessor, which is used to control the sampling volume and the amount of sample added by the pipette (62).

5. The sample feeding device for a high-output crystallization system according to claim 1, characterized in that: The connecting rod (53) is S-shaped.

6. The sample feeding device for a high-output crystallization system according to claim 1, characterized in that: The workbench (1), multi-channel tray (2), solid sample cell (3) and liquid sample cell (4) are made of polycarbonate.

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