A magnetic rod oscillation mechanism and an oscillation elutriation device

Abstract

The utility model relates to nucleic acid detection technical field, concretely relates to a magnetic bar oscillation mechanism and oscillation elutriation equipment. Magnetic bar oscillation mechanism, include: magnetic bar cover, magnetic bar cover is at least two groups, and each group magnetic bar cover is separately installed on the magnetic bar cover mounting frame through a rotating stand independently, rotating stand is driven to rotate to drive the magnetic bar cover on this rotating stand switches between the working position and the avoidance position, magnetic bar is adapted to multiple sets of magnetic bar cover, when the magnetic bar is inserted into the corresponding magnetic bar cover, the magnetic bar cover is driven to move up and down, realizes the mixing of sample in the magnetic bead method reagent, cracking, combination, washing, elution. The above plurality of groups of magnetic bar cover can switch between the working position and the avoidance position according to the need, so that the operator can adjust the number of magnetic bar cover according to the need, thereby solving the low work efficiency of the magnetic bar oscillation mechanism in the prior art, and the problem that multiple libraries of the oscillation elutriation equipment cannot be selected simultaneously.

Description

Technical Field

[0001] This utility model relates to the field of nucleic acid detection technology, specifically to a magnetic rod oscillation mechanism and an oscillation washing device. Background Technology

[0002] Nucleic acid processing or phage library panning both require the use of magnetic rods to vibrate the sample solution to be extracted. Especially when applying shaking and washing equipment to phage panning, it is necessary to increase the panning throughput by simultaneously panning multiple libraries during the process.

[0003] However, in existing technologies, the extraction method for nucleic acid extractors using the magnetic bead method is as follows: first, the sample is agitated for about 10 seconds to elute pathogens on the swab into the virus preservation solution as much as possible; then, 200 μL of sample is aspirated into the sample lysis buffer, and finally, nucleic acid is extracted using the nucleic acid extractor. In existing nucleic acid extractors, the oscillation structure typically uses a vibration motor to drive a magnetic rod to vibrate the sample solution to be extracted. For example, patent document CN217855827U discloses an oscillation structure for a nucleic acid extractor that can improve nucleic acid extraction efficiency. This structure includes: a support, a slide rail on the support, and a magnetic rod mounting plate on one slider of the slide rail. A magnetic rod sleeve mounting plate is located below the magnetic rod mounting plate on the other slider of the slide rail. In this technical solution, a conveying mechanism is respectively provided on the opposite side walls of the support to drive the magnetic rod sleeve mounting plate and the magnetic rod mounting plate to move up and down. The conveying mechanism drives the magnetic rod to be repeatedly inserted into the magnetic rod sleeve, causing the sample solution to vibrate, thus completing the sample solution vibration operation. However, the existing oscillation structure used in nucleic acid extractors can only vibrate the sample solution to be extracted through a set of corresponding magnetic rods and magnetic rod sleeves. This results in insufficient panning throughput of the magnetic rod oscillation mechanism, making it difficult to simultaneously pan multiple libraries in the oscillation washing device, and also failing to meet the high-efficiency requirements of nucleic acid extraction. Therefore, those skilled in the art urgently need a new magnetic rod oscillation mechanism to increase the working efficiency of existing magnetic rod oscillation mechanisms. Utility Model Content

[0004] Therefore, the technical problem to be solved by this utility model is how to solve the problem that the working efficiency of the magnetic rod oscillation mechanism in the prior art is low and cannot meet the needs of simultaneous sifting of multiple documents in the oscillation washing equipment.

[0005] Therefore, this utility model provides a magnetic rod oscillation mechanism, comprising:

[0006] The magnetic rod sleeves are in at least two sets, and each set of magnetic rod sleeves is independently mounted on a magnetic rod sleeve mounting frame via a rotating frame; the rotating frame is driven to rotate so as to switch the magnetic rod sleeves on the rotating frame between a working position and an avoidance position;

[0007] A magnetic rod is adapted to multiple sets of magnetic rod sleeves; when the magnetic rod is inserted into the corresponding magnetic rod sleeve, the magnetic rod sleeve is driven to move up and down, thereby realizing the mixing, lysis, binding, washing and elution of the sample in the magnetic bead reagent.

[0008] Optionally, the rotating frame includes: a rotating support arm, a fixed support arm, and a support arm pivot; the magnetic rod is sleeved on the rotating support arm and rotatably connected to the fixed support arm via the support arm pivot.

[0009] In the working position, the rotating arm corresponds to the position of the magnetic rod mounting bracket so that the magnetic rod and the magnetic rod sleeve can be inserted into each other; in the avoidance position, the rotating arm is away from the magnetic rod mounting bracket so as to avoid the rotating arm from affecting the operation of the rotating arm on another set of rotating frames.

[0010] Optionally, the rotating frame further includes: a locating pin;

[0011] The rotating support arm is provided with positioning holes corresponding to the working position and the avoidance position respectively. The positioning pin passes through the positioning holes on the fixed support arm and the rotating support arm in sequence to fix the rotating support arm in the working position or the avoidance position.

[0012] Optionally, the angle between the rotating arm and the fixed arm is 0 degrees; in the avoidance position, the angle between the rotating arm and the fixed arm is 90 degrees.

[0013] Optionally, the fixed support arm facing the rotating support arm is further provided with a receiving groove for accommodating the rotating support arm; the rotating support arm is rotatably disposed in the receiving groove via the support arm pivot.

[0014] The rotating frame further includes: a gap-eliminating block disposed on the rotating support arm; the side of the gap-eliminating block abuts against the outer contour of the opening of the receiving groove on the fixed support arm to position the rotation angle of the rotating support arm as 90 degrees; the end face of the gap-eliminating block abuts against the bottom surface of the receiving groove on the fixed support arm to position the rotation angle of the rotating support arm as 0 degrees.

[0015] Optionally, a groove is provided along the length of the rotating arm; when there are multiple grooves, the multiple grooves are arranged along the radial direction of the rotating arm at the bottom position or both sides of the rotating arm.

[0016] Each set of magnetic rod sleeves is inserted and fixed in the slide groove so that different numbers of magnetic rod sleeves can be installed on the rotating support arm as needed.

[0017] Optionally, the magnetic rod oscillation mechanism also includes:

[0018] The magnetic rod lifting mechanism is connected to the magnetic rod mounting frame to drive the magnetic rod mounting frame to lift and insert the magnetic rod into any of the corresponding magnetic rod sleeves.

[0019] The magnetic rod sleeve lifting mechanism is connected to the magnetic rod sleeve mounting frame to drive the magnetic rod sleeve mounting frame to lift and lower, and is used to place and remove the magnetic rod sleeve from the magnetic bead raw liquid.

[0020] Optionally, the magnetic rod lifting mechanism serves as a magnetic rod sleeve oscillation mechanism, driving the magnetic rod sleeve to move up and down to achieve the sample vibration process.

[0021] Optionally, there are two magnetic rod sleeve mounting brackets, and the magnetic rod mounting brackets are arranged between the two magnetic rod sleeve mounting brackets; each magnetic rod sleeve mounting bracket is provided with a rotating frame, and at least two sets of magnetic rods are arranged in the length direction of the rotating arm of each rotating frame;

[0022] There are two sets of magnetic rod sleeve lifting mechanisms, which drive the two magnetic rod sleeve mounting frames to lift and lower respectively; and the two sets of magnetic rod sleeve lifting mechanisms are arranged on both sides of the magnetic rod lifting mechanism in the horizontal direction.

[0023] An oscillating washing device includes: a magnetic rod oscillation mechanism; and a multi-channel pipette, which is driven to move for performing reagent preparation and addition and reagent transfer operations.

[0024] Optionally, the oscillating washing equipment has mounting positions for a first sample container and a second sample container inside the equipment;

[0025] Each set of magnetic rod sleeves includes multiple magnetic rod sleeves, and the multiple magnetic rod sleeves respectively form a first magnetic rod sleeve group and a second magnetic rod sleeve group. The magnetic rod sleeves of the first magnetic rod sleeve group correspond to the mounting position of the first sample container, and the magnetic rod sleeves of the second magnetic rod sleeve group correspond to the mounting position of the second sample container.

[0026] The arrangement direction of the first sample container and the second sample container is parallel to the arrangement direction of the multiple magnetic rod sleeves within each set of magnetic rod sleeves.

[0027] The technical solution of this utility model has the following advantages:

[0028] 1. The magnetic rod oscillation mechanism provided by this utility model includes:

[0029] The magnetic rod sleeves are in at least two sets, and each set of magnetic rod sleeves is independently mounted on a magnetic rod sleeve mounting frame via a rotating frame; the rotating frame is driven to rotate so as to switch the magnetic rod sleeves on the rotating frame between a working position and an avoidance position;

[0030] A magnetic rod is adapted to multiple sets of magnetic rod sleeves; when the magnetic rod is inserted into the corresponding magnetic rod sleeve, the magnetic rod sleeve is driven to move up and down, thereby realizing the mixing, lysis, binding, washing and elution of the sample in the magnetic bead reagent.

[0031] To address the problem of low efficiency in existing magnetic rod oscillation mechanisms, which cannot simultaneously process multiple libraries in oscillation washing equipment, this invention employs multiple sets of magnetic rod sleeves. During the driven up-and-down movement of these sleeves, the samples are effectively oscillated, enabling reagent mixing, lysis, binding, washing, and elution.

[0032] 2. The magnetic rod oscillation mechanism provided by this utility model includes a rotating frame comprising: a rotating support arm, a fixed support arm, and a support arm pivot; the magnetic rod is sleeved on the rotating support arm and rotatably connected to the fixed support arm via the support arm pivot.

[0033] In the working position, the rotating arm corresponds to the position of the magnetic rod mounting bracket so that the magnetic rod and the magnetic rod sleeve can be inserted into each other; in the avoidance position, the rotating arm is away from the magnetic rod mounting bracket so as to avoid the rotating arm from affecting the operation of the rotating arm on another set of rotating frames.

[0034] While performing simultaneous screening of multiple phages, in order to ensure that operators can adjust the magnetic rod sleeves as needed, each set of the aforementioned magnetic rod sleeves in this utility model is respectively mounted on a magnetic rod sleeve mounting frame via a rotating frame. This allows the magnetic rod sleeves to be moved out of the working position via the rotating frame when they are not needed, thereby adapting to different phage screening throughput requirements.

[0035] 3. The magnetic rod oscillation mechanism provided by this utility model further includes a positioning pin on the rotating frame; the rotating support arm is provided with positioning holes corresponding to the working position and the avoidance position respectively, and the positioning pin passes through the positioning holes on the fixed support arm and the rotating support arm in sequence to fix the rotating support arm in the working position or the avoidance position.

[0036] By inserting locating pins into the locating holes on the fixed and rotating support arms, the relative rotational positions of the fixed and rotating support arms can be securely and reliably fixed. Furthermore, the method of fixing the support arms with locating pins offers advantages such as accurate positioning and a simple and reliable structure.

[0037] 4. In the magnetic rod oscillation mechanism provided by this utility model, the angle between the rotating support arm and the fixed support arm is 0 degrees; in the avoidance position, the angle between the rotating support arm and the fixed support arm is 90 degrees.

[0038] In this invention, to ensure that the rotating support arm does not interfere with the normal operation of the magnetic rod when in the avoidance position, and that the magnetic rod sleeve in the working position also operates normally, the avoidance position is set to have an angle of 90 degrees between the rotating support arm and the fixed support arm.

[0039] 5. The magnetic rod oscillation mechanism provided by this utility model has a receiving groove for accommodating the rotating support arm on the side of the fixed support arm facing the rotating support arm; the rotating support arm is rotatably disposed in the receiving groove via the support arm pivot.

[0040] The rotating frame further includes: a gap-eliminating block disposed on the rotating support arm; the side of the gap-eliminating block abuts against the outer contour of the opening of the receiving groove on the fixed support arm to position the rotation angle of the rotating support arm as 90 degrees; the end face of the gap-eliminating block abuts against the bottom surface of the receiving groove on the fixed support arm to position the rotation angle of the rotating support arm as 0 degrees.

[0041] In this invention, to ensure that the rotation angle of the rotating arm is 0 degrees or 90 degrees, gap-eliminating blocks are also provided on the rotating arm. These gap-eliminating blocks are located on both sides along the length of the rotating arm, abutting against the concave cavities of the fixed arm to position the rotating arm at a 90-degree angle. Additionally, the gap-eliminating blocks are located on the end face of the rotating arm, abutting against the concave cavities of the fixed arm to position the rotating arm at a 0-degree angle.

[0042] 6. The magnetic rod oscillation mechanism provided by this utility model has a sliding groove provided along the length direction of the rotating support arm; when there are multiple sliding grooves, the multiple sliding grooves are arranged along the radial direction of the rotating support arm at the bottom position or both sides of the rotating support arm; each set of magnetic rod sleeves is inserted and fixed in the sliding groove, so that different numbers of magnetic rod sleeves can be installed on the rotating support arm as needed.

[0043] In this invention, a sliding groove is provided on the rotating support arm. This sliding groove allows the operator to install magnetic rod sleeves on the rotating support arm as needed, thereby changing the number of magnetic rod sleeves on each rotating support arm and consequently altering the working efficiency of the magnetic rod oscillation mechanism.

[0044] 7. The magnetic rod oscillation mechanism provided by this utility model further includes: a magnetic rod lifting mechanism, which is connected to the magnetic rod mounting frame to drive the magnetic rod mounting frame to lift and insert the magnetic rod into any of the corresponding magnetic rod sleeves; and a magnetic rod sleeve lifting mechanism, which is connected to the magnetic rod sleeve mounting frame to drive the magnetic rod sleeve mounting frame to lift and insert the magnetic rod sleeve into the magnetic bead stock solution.

[0045] Through the aforementioned magnetic rod sleeve lifting mechanism and magnetic rod lifting mechanism working together, the magnetic rod oscillation mechanism can effectively perform tasks such as mixing, cleavage, binding, washing, and elution of the sample magnetic bead reagent.

[0046] 8. The magnetic rod oscillation mechanism provided by this utility model has two magnetic rod sleeve mounting frames, each of which is provided with a rotating frame, and each of the rotating frames is provided with at least two sets of magnetic rods along the length of its rotating arm.

[0047] There are two sets of magnetic rod sleeve lifting mechanisms, which drive the two magnetic rod sleeve mounting frames to lift and lower respectively; and the two sets of magnetic rod sleeve lifting mechanisms are arranged on both sides of the magnetic rod lifting mechanism in the horizontal direction.

[0048] In this invention, two magnetic rod sleeve mounting brackets are provided, and the magnetic rod mounting brackets are positioned between the two magnetic rod sleeve mounting brackets. Furthermore, two sets of magnetic rod sleeve lifting mechanisms are symmetrically arranged on both sides of the magnetic rod lifting mechanism in the horizontal direction. This structural arrangement optimizes the spatial layout of the magnetic rod oscillation mechanism to the greatest extent possible, allowing for a miniaturized structure.

[0049] 9. The magnetic rod oscillation mechanism provided by this utility model, wherein the magnetic rod lifting mechanism serves as a magnetic rod sleeve oscillation mechanism, driving the magnetic rod sleeve to move up and down to achieve the sample vibration process.

[0050] In this invention, the driving source for the magnetic rod sleeve oscillation mechanism is a magnetic rod sleeve lifting mechanism. This lifting mechanism simultaneously places and removes the magnetic rod sleeve from the magnetic bead stock solution, and also performs the oscillation operation of the magnetic rod sleeve. This structural design effectively reduces the number of parts in the oscillation washing equipment and optimizes the overall structure of the equipment.

[0051] 10. The oscillating washing device provided by this utility model includes: a magnetic rod oscillation mechanism; and a multi-channel pipette, wherein the multi-channel pipette is driven to move and is used for reagent preparation and addition and reagent transfer in volumetric manner. The oscillating washing device provided by this utility model includes a magnetic rod oscillation mechanism, and therefore possesses all the advantages of a magnetic rod oscillation mechanism. Attached Figure Description

[0052] To more clearly illustrate the specific embodiments of this utility model or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this utility model. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0053] Figure 1 A three-dimensional structural schematic diagram of the magnetic rod oscillation mechanism provided by this utility model;

[0054] Figure 2 A schematic diagram showing the relative positions of the rotating frame and the magnetic rod mounting frame when one of the rotating arms is in the avoidance position and the other rotating arm is in the working position, provided by this utility model.

[0055] Figure 3 A schematic diagram of the connection structure between the rotating frame and the magnetic rod sleeve mounting frame provided by this utility model;

[0056] Figure 4 A schematic diagram of the connection structure between the magnetic rod lifting mechanism and the magnetic rod mounting frame provided by this utility model;

[0057] Figure 5 A schematic diagram showing the relative positions of the two sets of magnetic rod lifting mechanisms and the one set of magnetic rod lifting mechanisms provided by this utility model.

[0058] Explanation of reference numerals in the attached figures:

[0059] 1 – Magnetic rod sleeve; 2 – Rotating frame; 3 – Magnetic rod sleeve mounting frame; 4 – Magnetic rod; 5 – Rotating support arm; 6 – Fixed support arm; 7 – Support arm pivot; 8 – Positioning pin; 9 – Magnetic rod mounting frame; 10 – Receiving groove; 11 – Gap elimination block; 12 – Opening outer contour contact surface; 13 – Slide groove; 14 – Magnetic rod lifting mechanism; 15 – Magnetic rod sleeve lifting mechanism; 16 – First magnetic rod sleeve assembly; 17 – Second magnetic rod sleeve assembly. Detailed Implementation

[0060] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0061] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0062] Example 1

[0063] See Figure 1 and Figure 2 , Figure 1A three-dimensional structural schematic diagram of the magnetic rod oscillation mechanism in an embodiment of this utility model is shown. Figure 2 This diagram illustrates the relative positions of the rotating frame and the magnetic rod mounting frame when one rotating arm is in the avoidance position and the other rotating arm is in the working position, according to an embodiment of the present invention. The magnetic rod oscillation mechanism includes:

[0064] The magnetic rod sleeve 1 consists of two sets, each set of which is independently mounted on the magnetic rod sleeve mounting frame 3 via a rotating frame 2; the rotating frame 2 is driven to rotate, thereby switching the magnetic rod sleeve 1 on the rotating frame 2 between the working position and the avoidance position.

[0065] Magnetic rods 4 are adapted to two sets of magnetic rod sleeves 1. The magnetic rods 4 are mounted on magnetic rod mounting frames 9. When a magnetic rod 4 is driven to insert into its corresponding magnetic rod sleeve 1, the magnetic rod sleeve 1 moves up and down, achieving mixing, lysis, binding, washing, and elution of the sample in the magnetic bead reagent. In this embodiment, there are two magnetic rod sleeve mounting frames 3, and the magnetic rod mounting frame 9 is positioned between the two magnetic rod sleeve mounting frames 3. Each magnetic rod sleeve mounting frame 3 is equipped with a rotating frame 2, and at least two sets of magnetic rods 4 are arranged along the length of the rotating arm 5 of each rotating frame 2.

[0066] In a preferred embodiment, there are two sets of magnetic rod sleeve lifting mechanisms 15, which drive the two magnetic rod sleeve mounting frames 3 to lift and lower respectively; and the two sets of magnetic rod sleeve lifting mechanisms 15 are arranged on both sides of the magnetic rod lifting mechanism 14 in the horizontal direction.

[0067] Of course, in this embodiment, the number of magnetic rod sleeve mounting brackets 3 and magnetic rod mounting brackets 9 is not specifically limited. In other embodiments, there may be three magnetic rod sleeve mounting brackets 3, and one magnetic rod mounting bracket 9 that is compatible with the three mentioned above. Of course, two magnetic rod mounting brackets 9 can also be compatible with four magnetic rod sleeve mounting brackets 3. Alternatively, any other combination is possible.

[0068] In a preferred embodiment, see [reference] Figure 4 The diagram shows the connection structure between the magnetic rod lifting mechanism and the magnetic rod mounting bracket. And, Figure 5 The diagram shows the relative positions of two sets of magnetic rod lifting mechanisms and one set of magnetic rod lifting mechanisms. The magnetic rod oscillation mechanism also includes:

[0069] The magnetic rod lifting mechanism 14 is connected to the magnetic rod mounting frame 9 to drive the magnetic rod mounting frame 9 to lift and insert the magnetic rod 4 into any of the corresponding magnetic rod sleeves 1.

[0070] The magnetic rod sleeve lifting mechanism 15 is connected to the magnetic rod sleeve mounting frame 3 to drive the magnetic rod sleeve mounting frame 3 to lift and lower, and is used to place and remove the magnetic rod sleeve 1 from the magnetic bead raw liquid.

[0071] Specifically, in a preferred embodiment of this example, as Figure 5 As shown, the magnetic rod lifting mechanism 14 serves as a magnetic rod sleeve oscillation mechanism, driving the magnetic rod sleeve 1 to move up and down to achieve the sample vibration process. The magnetic rod sleeve lifting mechanism simultaneously completes the placement and removal of the magnetic bead stock solution, as well as the oscillation of the magnetic rod sleeve. This structural design effectively reduces the number of parts in the oscillation washing equipment and optimizes the overall structure of the equipment.

[0072] In a preferred embodiment, see [reference] Figure 3 The diagram shows the connection structure between the rotating frame and the magnetic rod sleeve mounting frame. The rotating frame 2 includes: a rotating support arm 5, a fixed support arm 6, and a support arm pivot 7; the magnetic rod sleeve 1 is mounted on the rotating support arm 5 and is rotatably connected to the fixed support arm 6 through the support arm pivot 7;

[0073] In the working position, the rotating support arm 5 corresponds to the magnetic rod mounting bracket 9 used to fix the magnetic rod 4, so that the magnetic rod 4 and the magnetic rod sleeve 1 can be inserted into each other; in the avoidance position, the rotating support arm 5 is away from the magnetic rod mounting bracket 9, so as to avoid the rotating support arm 5 affecting the operation of the rotating support arm 5 on another set of rotating brackets 2.

[0074] Specifically, in a preferred embodiment of this embodiment, the rotating frame 2 further includes: a positioning pin 8; the rotating support arm 5 is provided with positioning holes corresponding to the working position and the avoidance position respectively, and the positioning pin 8 passes through the positioning holes on the fixed support arm 6 and the rotating support arm 5 in sequence to fix the rotating support arm 5 in the working position or the avoidance position.

[0075] Furthermore, to ensure that the rotating support arm 5 does not interfere with the normal operation of the magnetic rod 4 in the avoidance position, and that the magnetic rod sleeve 1 in the working position operates normally, the angle between the rotating support arm 5 and the fixed support arm 6 is 0 degrees in the working position and 90 degrees in the avoidance position. Of course, in this embodiment, the specific angle between the rotating support arm 5 and the fixed support arm 6 in the working and avoidance positions can be adjusted as needed.

[0076] Furthermore, to ensure that the rotation angle of the rotating support arm 5 can be fixed at 0 degrees or 90 degrees, and that the working position and avoidance position of the rotating support arm 5 will not shift, the positioning pin 8 can accurately pass through the positioning holes on the fixed support arm 6 and the rotating support arm 5, thus firmly fixing them together. Figure 3The diagram shows the connection structure between the rotating frame and the magnetic rod sleeve mounting bracket. The fixed support arm 6, facing the rotating support arm 5, is also provided with a receiving groove 10 for accommodating the rotating support arm 5; the rotating support arm 5 is rotatably mounted within the receiving groove 10 via the support arm pivot 7.

[0077] The rotating frame 2 further includes: a gap-eliminating block 11 disposed on the rotating support arm 5; the side of the gap-eliminating block 11 abuts against the outer contour contact surface 12 of the opening of the receiving groove 10 on the fixed support arm 6 to position the rotation angle of the rotating support arm 5 as 90 degrees; the end face of the gap-eliminating block 11 abuts against the bottom surface of the receiving groove 10 on the fixed support arm 6 to position the rotation angle of the rotating support arm 5 as 0 degrees.

[0078] In a preferred embodiment, see [reference] Figure 1 and Figure 2 The diagram shows a three-dimensional structure of the magnetic rod oscillation mechanism. A sliding groove 13 is also provided along the length of the rotating arm 5; the number of sliding grooves 13 can be arbitrary, with multiple sliding grooves 13 arranged along the radial direction of the rotating arm 5, at the bottom of the rotating arm 5, or on both sides of the rotating arm 5; each set of magnetic rod sleeves 1 is inserted and fixed within the sliding groove 13, allowing different numbers of magnetic rod sleeves 1 to be installed on the rotating arm 5 as needed. Through the aforementioned sliding grooves 13, the operator can install the magnetic rod sleeves 1 on the rotating arm 5 as needed, thereby changing the number of magnetic rod sleeves 1 on each rotating arm 5, and thus changing the working efficiency of the magnetic rod oscillation mechanism.

[0079] Example 2

[0080] An oscillating washing device includes: the magnetic rod oscillation mechanism of Example 1; and a multi-channel pipette, which is driven to move for performing reagent preparation and addition and reagent transfer operations.

[0081] In a preferred embodiment, according to Figure 4 The diagram shows the connection structure between the magnetic rod sleeve lifting mechanism and the magnetic rod sleeve mounting frame. The automated phage library screening device in this embodiment has mounting positions for a first sample container and a second sample container. Further, in this embodiment, the arrangement direction of the first and second sample containers is parallel to the arrangement direction of the multiple magnetic rod sleeves within each group of magnetic rod sleeves 1, thereby ensuring that the sample containers correspond to the magnetic rod sleeves. Moreover, each group of magnetic rod sleeves 1 includes multiple magnetic rod sleeves, and the multiple magnetic rod sleeves respectively constitute... Figure 4The first magnetic rod sleeve assembly 16 and the second magnetic rod sleeve assembly 17 are shown. The magnetic rod sleeve of the first magnetic rod sleeve assembly 16 corresponds to the mounting position of the first sample container, and the magnetic rod sleeve of the second magnetic rod sleeve assembly 17 corresponds to the mounting position of the second sample container. When the magnetic rod sleeve 1 is in the working position, the first magnetic rod sleeve assembly 16 and the second magnetic rod sleeve assembly 17 will cover the first sample container and the second sample container respectively, thereby realizing simultaneous oscillation and washing of different sample containers, and thus effectively increasing the liquid phase washing efficiency of the washing equipment.

[0082] Of course, in this embodiment, the specific number of magnetic rod sleeves on each set of magnetic rod sleeves 1, and the number of sample containers corresponding to each set of magnetic rod sleeves 1, are not specifically limited. In other embodiments, each set of magnetic rod sleeves 1 may also be provided with one, three, or more sets of magnetic rod sleeves as needed. Correspondingly, the number of sample containers corresponding to each set of magnetic rod sleeves 1 also needs to be set accordingly.

[0083] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art will recognize that other variations or modifications can be made based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the protection scope of this invention.

Claims

1. A magnetic bar oscillation mechanism characterized by comprising: include: Magnetic rod sleeve (1), the magnetic rod sleeve (1) is in at least two sets, each set of the magnetic rod sleeve (1) is independently mounted on the magnetic rod sleeve mounting frame (3) by a rotating frame (2); the rotating frame (2) is driven to rotate so as to drive the magnetic rod sleeve (1) on the rotating frame (2) to switch between the working position and the avoidance position; A magnetic rod (4) is adapted to multiple sets of magnetic rod sleeves (1); when the magnetic rod (4) is inserted into the corresponding magnetic rod sleeve (1), the magnetic rod sleeve (1) moves up and down under drive.

2. The magnetic bar oscillation mechanism according to claim 1, characterized by The rotating frame (2) includes: a rotating support arm (5), a fixed support arm (6), and a support arm pivot (7); the magnetic rod sleeve (1) is installed on the rotating support arm (5) and is rotatably connected to the fixed support arm (6) through the support arm pivot (7); In the working position, the rotating arm (5) corresponds to the magnetic rod mounting bracket (9) used to fix the magnetic rod (4) so ​​that the magnetic rod (4) and the magnetic rod sleeve (1) can be inserted into each other; in the avoidance position, the rotating arm (5) is away from the magnetic rod mounting bracket (9) so as to avoid the rotating arm (5) from affecting the operation of the rotating arm (5) on another set of rotating brackets (2).

3. The magnetic rod oscillation mechanism according to claim 2, characterized in that, The rotating frame (2) also includes: a positioning pin (8); The rotating support arm (5) is provided with positioning holes corresponding to the working position and the avoidance position respectively. The positioning pin (8) passes through the positioning holes on the fixed support arm (6) and the rotating support arm (5) in sequence to fix the rotating support arm (5) in the working position or the avoidance position.

4. The magnetic rod oscillation mechanism according to claim 2 or 3, characterized in that, In the working position, the angle between the rotating arm (5) and the fixed arm (6) is 0 degrees; in the avoidance position, the angle between the rotating arm (5) and the fixed arm (6) is 90 degrees.

5. The magnetic rod oscillation mechanism according to claim 4, characterized in that, The fixed support arm (6) facing the rotating support arm (5) is also provided with a receiving groove (10) for accommodating the rotating support arm (5); the rotating support arm (5) is rotatably disposed in the receiving groove (10) via the support arm pivot (7); The rotating frame (2) further includes: a gap elimination block (11) disposed on the rotating support arm (5); the side position of the gap elimination block (11) abuts against the outer contour contact surface (12) of the opening of the receiving groove (10) on the fixed support arm (6) to position the rotation angle of the rotating support arm (5) as 90 degrees; the end face position of the gap elimination block (11) abuts against the bottom surface of the receiving groove (10) on the fixed support arm (6) to position the rotation angle of the rotating support arm (5) as 0 degrees.

6. The magnetic rod oscillation mechanism according to claim 2, characterized in that, The rotating support arm (5) is provided with a sliding groove (13) along its length; when there are multiple sliding grooves (13), the multiple sliding grooves (13) are arranged along the radial direction of the rotating support arm (5) at the bottom position or on both sides of the rotating support arm (5); Each set of magnetic rod sleeves (1) is inserted and fixed in the slide groove (13) so that different numbers of magnetic rod sleeves (1) can be installed on the rotating support arm (5) as needed.

7. The magnetic rod oscillation mechanism according to claim 2, characterized in that, Also includes: The magnetic rod lifting mechanism (14) is connected to the magnetic rod mounting frame (9) to drive the magnetic rod mounting frame (9) to lift and lower, inserting the magnetic rod (4) into any of the corresponding magnetic rod sleeves (1); The magnetic rod sleeve lifting mechanism (15) is connected to the magnetic rod sleeve mounting frame (3) to drive the magnetic rod sleeve mounting frame (3) to lift and lower, and to place and remove the magnetic rod sleeve (1) from the magnetic bead raw liquid.

8. The magnetic rod oscillation mechanism according to claim 7, characterized in that, The magnetic rod lifting mechanism (14) serves as a magnetic rod sleeve oscillation mechanism, driving the magnetic rod sleeve (1) to move up and down to achieve the sample vibration process.

9. The magnetic rod oscillation mechanism according to claim 7 or 8, characterized in that, There are two magnetic rod sleeve mounting brackets (3), and the magnetic rod mounting bracket (9) is set between the two magnetic rod sleeve mounting brackets (3); each magnetic rod sleeve mounting bracket (3) is provided with a rotating bracket (2), and at least two sets of magnetic rods (4) are provided in the length direction of the rotating support arm (5) of each rotating bracket (2); There are two sets of magnetic rod sleeve lifting mechanisms (15), which drive the two magnetic rod sleeve mounting brackets (3) to lift and lower respectively; and the two sets of magnetic rod sleeve lifting mechanisms (15) are arranged on both sides of the magnetic rod lifting mechanism (14) in the horizontal direction.

10. A vibrating washing device, characterized in that, include: The magnetic rod oscillation mechanism according to any one of claims 1 to 9; as well as, A multichannel pipette, which is driven to move, is used for dispensing and transferring reagents in volume.

11. The vibrating washing device according to claim 10, characterized in that, The oscillating washing equipment has mounting positions for a first sample container and a second sample container inside the equipment; Each set of magnetic rod sleeves (1) includes multiple magnetic rod sleeves, and the multiple magnetic rod sleeves respectively form a first magnetic rod sleeve group (16) and a second magnetic rod sleeve group (17). The magnetic rod sleeves of the first magnetic rod sleeve group (16) correspond to the mounting position of the first sample container, and the magnetic rod sleeves of the second magnetic rod sleeve group (17) correspond to the mounting position of the second sample container. The arrangement direction of the first sample container and the second sample container is parallel to the arrangement direction of the multiple magnetic rod sleeves in each set of magnetic rod sleeves (1).

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