A reactor for L-cystine acetylation

Abstract

This utility model discloses an L-cysteine ​​acetylation reactor. The reactor body has a lid on its upper surface and multiple liquid inlets connected to the lid. The bottom of each liquid inlet passes through the lid and connects to a base. Several inclined tubes are evenly arranged around the base, and the bottoms of these tubes are connected to a ring. Several feed holes are evenly arranged on the lower surface of the ring. The L-cysteine ​​feed inlet is connected to the lid, and its bottom passes through the lid and is equipped with crossbars arranged in a triangular cross-section. This utility model has a reasonable structure. The crossbars arranged in a triangular cross-section allow crystalline powdered L-cysteine ​​to enter the reactor body evenly through the L-cysteine ​​feed inlet. Simultaneously, the liquid inlet, through the base, inclined tubes, and the ring with feed holes, allows various liquid materials to be evenly added into the reactor body, improving the dispersion and contact between materials, thereby enhancing the reaction effect and efficiency of L-cysteine ​​acetylation.

Description

Technical Field

[0001] This utility model relates to the field of reaction vessel technology, specifically to an L-cysteine ​​acetylation reaction vessel. Background Technology

[0002] N-acetyl-L-cysteine ​​is an acetylated derivative of cysteine. Its molecule contains a thiol group, which can break the disulfide bonds in mucin peptide bonds, giving it high medicinal value. It is widely used in the treatment of respiratory diseases and can also be made into eye drops for the treatment of various types of keratitis. In recent years, the demand for N-acetyl-L-cysteine ​​in domestic and international markets has expanded rapidly. As a raw material, it is mainly used in the manufacture of compound amino acid injections and expectorants. Currently, a novel production process involves first acetylifying L-cysteine ​​and then electrochemically reducing it to prepare N-acetyl-L-cysteine. The acetylation of L-cysteine ​​is generally completed in a reaction vessel.

[0003] The raw materials required for L-cysteine ​​acetylation are mainly L-cysteine, glacial acetic acid, liquid alkali, hydrochloric acid, sulfuric acid, and deionized water. Among them, L-cysteine ​​is in crystalline powder form, while the other raw materials are liquids. Existing L-cysteine ​​acetylation reactors generally have straight cylindrical structures for each feed inlet, allowing the material to fall directly into the reactor body. However, this feeding structure results in insufficient material dispersion and uniformity, leading to a reduction in the reaction effect and efficiency of L-cysteine ​​acetylation. Therefore, an improved technology is urgently needed to solve this problem in the existing technology. Utility Model Content

[0004] The purpose of this invention is to provide an L-cysteine ​​acetylation reactor to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, this utility model provides the following technical solution: an L-cysteine ​​acetylation reactor, comprising a reactor body, a reactor cover, a stirring shaft, a stirring paddle, a liquid inlet, and an L-cysteine ​​inlet;

[0006] The upper surface of the vessel body is provided with a vessel lid, and a motor is provided at the center of the upper surface of the vessel lid via a motor mount. The output shaft of the motor is connected to the top of the stirring shaft via a coupling. A stirring paddle is provided at the bottom of the stirring shaft and is rotatably mounted inside the vessel body.

[0007] The liquid inlet has multiple ports and is connected to the vessel lid. The bottom of each liquid inlet passes through the vessel lid and is connected to a base. Several inclined tubes are evenly arranged around the base. The bottom of each inclined tube is connected to a ring. Several feed holes are evenly arranged on the lower surface of the ring.

[0008] The L-cystine inlet is connected to the vessel lid, and the bottom of the L-cystine inlet passes through the vessel lid and is provided with crossbars arranged in a crisscross pattern. The crossbars have a triangular cross section.

[0009] Preferably, the L-cystine acetylation reactor provided by this utility model has a jacket covering the outside of the reactor body, the jacket having a heat exchange medium inlet and a heat exchange medium outlet, and a plurality of support seats on the outer surface of the jacket.

[0010] Preferably, the L-cysteine ​​acetylation reactor provided by this utility model has a discharge port located at the center of the bottom of the reactor body.

[0011] Preferably, the L-cysteine ​​acetylation reactor provided by this utility model is provided with a thermometer port and a pressure gauge port on the reactor lid.

[0012] Compared with the prior art, the beneficial effects of this utility model are:

[0013] The reactor lid is equipped with one L-cystine inlet and multiple liquid inlets. The bottom of the L-cystine inlet is equipped with crossbars arranged in a triangular cross section to allow the crystalline powdered L-cystine to enter the reactor evenly. At the same time, the bottom of the liquid inlets is equipped with a base, an inclined tube, and a ring with a feed hole to allow various liquid materials to be added evenly into the reactor, thereby improving the dispersion and contact between materials and thus improving the reaction effect and efficiency of L-cystine acetylation. Attached Figure Description

[0014] Figure 1 This is a schematic diagram of the structure of this utility model;

[0015] Figure 2 For the appendix Figure 1 Enlarged structural diagram of point A in the middle;

[0016] Figure 3 This is a bottom view of the structure of the present invention located at the ring body;

[0017] Figure 4 This is a schematic diagram of the cross-sectional structure of the present invention located at the ring body;

[0018] Figure 5 This is a top view of the structure of the present invention located at the L-cystine inlet.

[0019] In the diagram: 1. Vessel body; 2. Vessel cover; 3. Stirring shaft; 4. Stirring paddle; 5. Liquid inlet; 6. L-cystine inlet; 7. Motor; 8. Base; 9. Inclined tube; 10. Ring body; 11. Feed hole; 12. Crossbar; 13. Jacket; 14. Heat exchange medium inlet; 15. Heat exchange medium outlet; 16. Support seat; 17. Discharge port; 18. Thermometer port; 19. Pressure gauge port. Detailed Implementation

[0020] The technical solution of this utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the protection scope of this utility model.

[0021] It should be noted that in the description of this utility model, the terms "inner", "outer", "upper", "lower", "both sides", "one end", "the other end", "left", "right", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0022] Please see Figure 1-5 This utility model provides a technical solution: an L-cysteine ​​acetylation reactor, including a reactor body 1, a reactor cover 2, a stirring shaft 3, a stirring paddle 4, a liquid inlet 5, and an L-cysteine ​​inlet 6;

[0023] A lid 2 is provided on the upper surface of the vessel body 1. A motor 7 is provided at the center of the upper surface of the lid 2 via a motor base. The output shaft of the motor 7 is connected to the top of the stirring shaft 3 via a coupling. A stirring paddle 4 is provided at the bottom of the stirring shaft 3. The stirring paddle 4 is rotatably disposed inside the vessel body 1. The vessel body 1 is wrapped with a jacket 13. The jacket 13 is provided with a heat exchange medium inlet 14 and a heat exchange medium outlet 15. The working temperature inside the vessel body 1 is controlled through the jacket 13. The heat exchange medium inlet 14 and the heat exchange medium outlet 15 are used for the entry and exit of the heat exchange medium. Several support seats 16 are also provided on the outer surface of the jacket 13. The support seats 16 are used to support and fix the vessel body 1. A discharge port 17 is provided at the center of the bottom of the vessel body 1 to discharge the material.

[0024] There are multiple liquid inlets 5, all of which are connected to the vessel cover 2. The bottom of the liquid inlet 5 passes through the vessel cover 2 and is connected to the base 8. Several inclined tubes 9 are evenly arranged around the base 8. The bottom of each inclined tube 9 is connected to the ring body 10. Several feed holes 11 are evenly arranged on the lower surface of the ring body 10.

[0025] The L-cystine inlet 6 is connected to the vessel cover 2. The bottom of the L-cystine inlet 6 passes through the vessel cover 2 and is equipped with crossbars 12 arranged in a cross pattern. The crossbars 12 have a triangular cross section. The purpose of using crossbars 12 with a triangular cross section is twofold: first, when L-cystine falls on the crossbar, it is dispersed outward along the slope; second, it avoids L-cystine from accumulating on the crossbars 12.

[0026] The vessel lid 2 is also equipped with a thermometer port 18 and a pressure gauge port 19 to allow for the installation of a thermometer and a pressure gauge, respectively, thereby enabling the monitoring of temperature and pressure inside the vessel body 1.

[0027] Installation method and operating principle: Pass the L-cystine inlet 6 and multiple liquid inlets 5 through the vessel cover 2 and weld them to the vessel cover 2. Then, weld the top of the base 8, which is connected to the inclined tube 9, to the bottom of each liquid inlet 5. Next, weld the ring 10 to the outer end of each inclined tube 9. The lower surface of the ring 10 has several evenly spaced feed holes 11. Then, weld the crossbars 12 to the bottom inside the L-cystine inlet 6. Install the motor 7 in the center of the vessel cover 2 via a motor mount. Connect the top of the stirring shaft 3, which is connected to the stirring paddle 4, to the output shaft of the motor 7 via a coupling. After lifting the vessel cover 2, place the stirring paddle 4 into the vessel body 1, and then fasten the vessel cover 2 to the vessel body 1 with bolts to complete the installation. In operation, L-cysteine ​​in crystalline powder form is fed into the reactor body 1 through the L-cysteine ​​inlet 6. Before entering the reactor body 1, the L-cysteine ​​is dispersed into the reactor body 1 by passing through crossbars 12 with triangular cross-sections arranged at the bottom of the L-cysteine ​​inlet 6. Simultaneously, liquid materials such as glacial acetic acid, liquid alkali, hydrochloric acid, sulfuric acid, and deionized water enter the reactor body 1 through various liquid inlets 5. Before entering the reactor body 1, these materials flow into the ring body 10 through the base 8 and inclined tube 9, and then enter the reactor body 1 evenly and separately through various feed holes 11 at the bottom of the ring body 10. Next, the motor 7 is started, which drives the stirring shaft 3 to rotate. The stirring shaft 3 drives the stirring paddle 4 to stir the materials. During the stirring process, a heat exchange medium is introduced into the jacket 13 to maintain the reaction temperature in the reactor body 1 at 0–55°C. This temperature can be increased in a stepwise manner to achieve the acetylation of L-cysteine. This utility model has a reasonable structure. The kettle cover 2 is provided with an L-cysteine ​​inlet 6 and multiple liquid inlets 5. The bottom of the L-cysteine ​​inlet 6 is connected by crossbars 12 with triangular cross sections to allow the crystalline powder L-cysteine ​​to enter the kettle body 1 evenly. At the same time, the bottom of the liquid inlets 5 is connected by a base 8, an inclined tube 9 and a ring 10 with a feed hole 11 to allow various liquid materials to be added evenly into the kettle body 1, thereby improving the dispersion and contact between materials and thus improving the reaction effect and efficiency of L-cysteine ​​acetylation.

[0028] Any aspects of this utility model not described in detail are well-known technologies to those skilled in the art.

[0029] Finally, it should be noted that the above specific embodiments are only used to illustrate the technical solution of this utility model and not to limit it. Although this utility model has been described in detail with reference to the embodiments, those skilled in the art should understand that modifications and equivalent substitutions can be made to the technical solution of this utility model without departing from the spirit and scope of the technical solution of this utility model, and all such modifications and substitutions should be covered within the scope of the claims of this utility model.

Claims

1. An L-cysteine ​​acetylation reactor, characterized in that: It includes a vessel body (1), a vessel cover (2), a stirring shaft (3), a stirring paddle (4), a liquid inlet (5), and an L-cystine inlet (6); The upper surface of the vessel body (1) is provided with a vessel cover (2), and a motor (7) is provided at the center of the upper surface of the vessel cover (2) through a motor seat. The output shaft of the motor (7) is connected to the top of the stirring shaft (3) through a coupling. A stirring paddle (4) is provided at the bottom of the stirring shaft (3), and the stirring paddle (4) is rotatably disposed inside the vessel body (1). There are multiple liquid inlets (5) and they are all connected to the lid (2). The bottom of the liquid inlet (5) passes through the lid (2) and is connected to the base (8). Several inclined tubes (9) are evenly arranged around the base (8). The bottom of each inclined tube (9) is connected to the ring (10). Several feed holes (11) are evenly arranged on the lower surface of the ring (10). The L-cystine inlet (6) is connected to the kettle cover (2). The bottom of the L-cystine inlet (6) passes through the kettle cover (2) and is provided with crossbars (12) arranged in a cross pattern. The crossbars (12) have a triangular cross section.

2. The L-cysteine ​​acetylation reactor according to claim 1, characterized in that: The vessel body (1) is wrapped with a jacket (13), which is provided with a heat exchange medium inlet (14) and a heat exchange medium outlet (15). The outer surface of the jacket (13) is also provided with several support seats (16).

3. The L-cysteine ​​acetylation reactor according to claim 1, characterized in that: The bottom center of the vessel body (1) is provided with a discharge port (17).

4. The L-cysteine ​​acetylation reactor according to claim 1, characterized in that: The lid (2) is also provided with a thermometer port (18) and a pressure gauge port (19).

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