A double-cone drying apparatus for carbamazepine bulk drug

Abstract

This utility model discloses a double-cone drying device for carbamazepine raw material, including a double-cone rotary box and a transverse main shaft. The transverse main shaft has circumferentially recessed mounting grooves on both sides, and the double-cone rotary box has cylindrical mounting parts extending laterally on both sides. The mounting parts on both sides of the double-cone rotary box are fitted onto the mounting grooves on both sides of the transverse main shaft. A drive mechanism is also installed on both sides of the transverse main shaft. In this device, the transverse main shaft is fixed, while the double-cone rotary box mounted on it rotates accordingly. Several drying heating plates are correspondingly mounted on the transverse main shaft. As the double-cone rotary box rotates, the drying heating plates heat accordingly. The design of the drying heating plates ensures uniform heat distribution within the double-cone rotary box, and the raw material can directly contact the drying heating plates, falling into the gaps between adjacent drying heating plates, significantly improving drying efficiency and quality.

Description

Technical Field

[0001] This utility model relates to the field of manufacturing technology and equipment for carbamazepine raw materials, specifically a double-cone drying device for carbamazepine raw materials. Background Technology

[0002] In existing technologies, carbamazepine raw material has anti-epileptic effects, which are used to treat various types of epileptic seizures, such as partial seizures and generalized tonic-clonic seizures, by inhibiting abnormal neuronal discharges and preventing the spread of discharges; it also has anti-neuralgia effects, showing good efficacy for peripheral neuralgia such as trigeminal neuralgia and glossopharyngeal neuralgia, and can effectively relieve pain symptoms; it has anti-manic-depressive effects, used to prevent or treat manic-depressive disorder, and can be used alone or in combination with other drugs for patients who are ineffective or intolerant of lithium, antipsychotics, or antidepressants; in addition, it can also be used to treat central partial diabetes insipidus, restless legs syndrome, and alcohol withdrawal syndrome.

[0003] The existing manufacturing process for carbamazepine active pharmaceutical ingredient includes the following steps:

[0004] Ammoniation reaction: Using the corresponding intermediate as raw material, an ammoniation reaction is carried out under certain conditions to introduce an amino group;

[0005] Distillation separation: The reaction products are separated and purified by distillation to remove impurities and unreacted raw materials;

[0006] Crystallization process: Using appropriate solvents and crystallization conditions, carbamazepine is crystallized from the solution to obtain crystals with high purity;

[0007] Centrifugal drying: The crystallized carbamazepine solid is separated by centrifugation and then dried to remove residual solvent and moisture, thus obtaining the finished carbamazepine raw material.

[0008] The centrifugal drying process often employs a double-cone dryer, a type of intermittent drying equipment. Its main body is a double-cone rotating tank. During operation, the tank rotates slowly under the drive of a driving device, causing the material to continuously tumble and mix within the tank. Simultaneously, heating elements are installed within the jacket to indirectly heat the material, causing the moisture or solvent in the material to evaporate. Due to the rotation of the tank, the material is heated evenly, resulting in a good drying effect.

[0009] However, in existing technologies, heating elements are often placed in the interlayer of the double-cone tank. This results in uneven internal heat distribution during heating, and heat can only be conducted through the air inside the double-cone tank. Consequently, the drying effect and the uniformity of heating are not significant enough and need to be improved.

[0010] Therefore, in order to solve the above problems, it is necessary to develop a double-cone drying device for carbamazepine raw materials with a reasonable structure that improves drying effect and uniform heating. Utility Model Content

[0011] The purpose of this invention is to address the shortcomings of existing technologies by providing a double-cone drying device for carbamazepine raw material; the technical solution is as follows:

[0012] A double-cone drying device for carbamazepine raw material includes a double-cone rotary box and a transverse main shaft corresponding to the double-cone rotary box; the transverse main shaft has circumferentially recessed mounting grooves on both sides, and the double-cone rotary box has cylindrical mounting parts extending laterally on both sides. The mounting parts on both sides of the double-cone rotary box are fitted onto the mounting grooves on both sides of the transverse main shaft, and a drive mechanism is also installed on both sides of the transverse main shaft. Under the action of the drive mechanism, the double-cone rotary box rotates on the transverse main shaft.

[0013] Several vertically arranged drying heating plates are also installed on the horizontal main shaft. The drying heating plates are set inside the double cone rotary box, and the outer diameter of the drying heating plates gradually decreases from the middle position of the horizontal main shaft to both sides.

[0014] Furthermore, the spacing between two adjacent drying heating plates on the transverse main shaft is the same.

[0015] Furthermore, the drying heating plate is embedded with a circumferential heating wire, which extends and is embedded on the transverse main shaft, and extends out from one side of the transverse main shaft to a corresponding power supply device; the heating wire causes the drying heating plate to generate heat.

[0016] Furthermore, the drying heating plate is also equipped with a horizontal heat-conducting plate. Each drying heating plate has a corresponding heat-conducting plate on both sides, and there is a gap between the other end of the heat-conducting plate and the adjacent drying heating plate. The heat-conducting plates on the adjacent drying heating plates are arranged alternately.

[0017] Furthermore, the heat-conducting plates on the drying heating plate are all triangular in structure, and there are gaps between the heat-conducting plates on the same drying heating plate.

[0018] Furthermore, the drying heating plate has seven symmetrically arranged on the transverse main axis, and the diameter of the drying heating plate is set according to the size of the double cone rotary box.

[0019] Furthermore, the upper end of the double cone rotary box is provided with a feed inlet and the lower end is provided with a discharge outlet, and both the feed inlet and the discharge outlet are equipped with hinged cover plates.

[0020] Furthermore, mounting seats are provided at both ends of the transverse main shaft, support columns are provided at the lower ends of the mounting seats on both sides, and the drive mechanism is provided at the upper end of the mounting seats.

[0021] Furthermore, the drive mechanism includes a drive motor, which is fixed on the mounting base. The drive motor's rotating shaft extends laterally to the inside, and a drive gear is installed at the shaft end.

[0022] The outer sides of the mounting portions at both ends of the double cone rotary box are also equipped with corresponding gear rings. The drive gear meshes with the gear ring, and the drive gear drives the gear ring to rotate, thereby driving the double cone rotary box to rotate.

[0023] Furthermore, wear-resistant sealing gaskets are also installed in the mounting portions on both sides of the double-cone rotary box.

[0024] Beneficial effects: This utility model has the following beneficial effects:

[0025] 1) In this device, the horizontal main shaft is fixed, while the double cone rotary box installed on the horizontal main shaft rotates accordingly. Several drying heating plates are installed on the horizontal main shaft. When the double cone rotary box rotates, the drying heating plates are heated accordingly. On the one hand, the design of the drying heating plates makes the heat in the double cone rotary box uniform. On the other hand, the raw material can directly contact the drying heating plates and fall into the gap between adjacent drying heating plates, which significantly improves the drying efficiency and drying quality.

[0026] 2) In this device, the transverse main shaft is set in a fixed form, and the double cone rotary box is designed to rotate. The specific installation of the main shaft and the double cone rotary box is achieved through the mounting grooves and mounting parts on both sides. The mounting grooves on both sides of the transverse main shaft are circumferentially recessed, while the double cone rotary box is provided with cylindrical mounting parts on both sides. The mounting parts can be correspondingly embedded in the mounting grooves to achieve the corresponding installation of the transverse main shaft and the double cone rotary box. The transverse main shaft is fixed, while the double cone rotary box rotates, resulting in a stable and reliable structure.

[0027] 3) The drying heating plate on the horizontal main shaft in this device is also fixed. The drying heating plate is heated by embedding heating wires inside. The power source is achieved through the wires embedded in the horizontal main shaft. After the wires extend from one end of the horizontal main shaft, a power supply device is installed to provide power to the heating wires in the drying heating plate, thereby realizing the heating of the drying heating plate. The structure is cleverly and reasonably designed. The overall drying heating plate does not need to rotate to effectively improve the drying effect.

[0028] 4) A heat-conducting plate is also installed on the drying heating plate in this device. The design of the heat-conducting plate can increase the heating area. When the outer double cone rotary box rotates, the raw material falls onto the adjacent drying heating plate and will fall onto the heat-conducting plate. The heat-conducting plate is made of heat-conducting material, so the raw material can be heated through the heat-conducting plate. The heat-conducting plate can directly contact the raw material, and the overall structure is more reasonable. In addition, the heat-conducting plate in this device is set into a triangular structure. The raw material will not accumulate on the heat-conducting plate when it rotates. After drying, it will fall directly off the heat-conducting plate.

[0029] 5) The transverse main shaft in this device also provides the driving power for the double cone rotary box. There are mounting seats at both ends of the transverse main shaft. The drive motor is mounted on the mounting seats on both sides. The drive gear is mounted on the shaft of the drive motor. Importantly, a gear ring is set on the outside of the mounting part. After the drive gear meshes with the gear ring, it can drive the double cone rotary box to rotate. The overall structure is reasonable. Attached Figure Description

[0030] Figure 1 This is a structural diagram of the present utility model;

[0031] Figure 2 This is a structural diagram of the transverse main shaft in this utility model;

[0032] Figure 3 for Figure 2 Sectional view of AA;

[0033] Figure 4 for Figure 2 View from direction B;

[0034] Figure 5 This is a diagram showing the installation position of the heat-conducting plate in this utility model;

[0035] Figure 6 for Figure 5 CC view;

[0036] The components include: a double cone rotary box 1; a transverse main shaft 2; a mounting groove 3; a mounting section 4; a drying heating plate 5; a heating wire 6; a feed inlet 8; a discharge outlet 9; a cover plate 10; a mounting base 11; a support column 12; a drive motor 13; a drive gear 14; a gear ring 15; and a heat-conducting plate 51. Detailed Implementation

[0037] The present invention will be further explained below with reference to the accompanying drawings and specific embodiments. These embodiments are implemented under the premise of the technical solution of the present invention. It should be understood that these embodiments are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0038] like Figure 1 and Figure 2As shown, a double-cone drying device for carbamazepine raw material includes a double-cone rotary box 1 and a transverse main shaft 2 installed corresponding to the double-cone rotary box 1; the transverse main shaft 2 is provided with circumferentially recessed mounting grooves 3 on both sides, and the double-cone rotary box 1 is provided with cylindrical mounting parts 4 extending laterally on both sides. The mounting parts 4 on both sides of the double-cone rotary box 1 are fitted onto the mounting grooves 3 on both sides of the transverse main shaft 2, and a drive mechanism is also installed on both sides of the transverse main shaft 2. Under the action of the drive mechanism, the double-cone rotary box 1 rotates on the transverse main shaft 2.

[0039] Several vertically arranged drying heating plates 5 are also installed on the horizontal main shaft 2. The drying heating plates 5 are set inside the double cone rotary box 1, and the outer diameter of the drying heating plates 5 gradually decreases from the middle position of the horizontal main shaft 2 to both sides.

[0040] The spacing between two adjacent drying heating plates 5 on the transverse main shaft 2 is the same.

[0041] like Figure 3 and Figure 4 As shown, the drying heating plate 5 is embedded with a circumferential heating wire 6, which extends and is embedded on the transverse main shaft 2. After extending out from one side of the transverse main shaft 2, a power supply device 7 is installed accordingly. The heating wire 6 causes the drying heating plate 5 to generate heat.

[0042] like Figure 5 and Figure 6 As shown, a horizontal heat-conducting plate 51 is also installed on the drying heating plate 5. Each drying heating plate 5 has a corresponding heat-conducting plate 51 on both sides. There is a gap between the other end of the heat-conducting plate 51 and the adjacent drying heating plate 5. The heat-conducting plates 51 on the adjacent drying heating plates 5 are arranged alternately.

[0043] The heat-conducting plates 51 on the drying heating plate 5 are all triangular in structure, and there are gaps between the heat-conducting plates 51 on the same drying heating plate 5.

[0044] There are seven symmetrical drying heating plates 5 on the transverse main shaft 2, and the diameter of the drying heating plates 5 is set according to the size of the double cone rotary box 1.

[0045] The upper end of the double cone rotary box 1 is provided with a feed inlet 8 and the lower end is provided with a discharge outlet 9, and both the feed inlet 8 and the discharge outlet 9 are equipped with hinged cover plates 10.

[0046] The horizontal spindle 2 is also provided with mounting bases 11 at both ends, and support columns 12 are provided at the lower ends of the mounting bases 11 on both sides, while the drive mechanism is provided at the upper end of the mounting bases 11.

[0047] The drive mechanism includes a drive motor 13, which is fixed on the mounting base 11. The drive motor 13 extends laterally into the inner side, and a drive gear 14 is installed at the shaft end.

[0048] A gear ring 15 is also installed on the outer side of the mounting part 4 at both ends of the double cone rotary box 1. The drive gear 14 meshes with the gear ring 15, and drives the gear ring 15 to rotate through the drive gear 14, thereby driving the double cone rotary box 1 to rotate.

[0049] Wear-resistant sealing gaskets are also installed inside the mounting parts 4 on both sides of the double cone rotary box 1.

[0050] The specific working principle of this device is as follows: The raw material to be dried enters through the feed inlet of the double-cone rotary box and is then sealed by the cover plate. During drying, the central transverse main shaft remains stationary, while the double-cone rotary box mounted on the transverse main shaft rotates accordingly. Several drying heating plates are mounted on the transverse main shaft, with equal distances between them and varying sizes. The drying heating plates on the transverse main shaft are symmetrically arranged according to the internal dimensions of the double-cone rotary box. The drying heating plate in the middle position is the largest, while the size of the drying heating plates on both sides gradually decreases, allowing the drying heating plates to be positioned within the entire double-cone rotary box.

[0051] As the double-cone rotary box rotates, the drying heating plates are heated accordingly. The active pharmaceutical ingredient (API) directly contacts the drying heating plates as the double-cone rotary box rotates. On the one hand, the design of the drying heating plates ensures uniform heat distribution within the double-cone rotary box. On the other hand, the API can directly contact the drying heating plates. Furthermore, since there are multiple drying heating plates, the API falls into the gaps between adjacent drying heating plates, significantly improving drying efficiency and quality. After drying, the API can be discharged through the discharge port. The structure is rationally designed.

[0052] The innovation of this device lies mainly in setting the transverse spindle to a fixed form and designing the double-cone rotary box to rotate. The specific installation of the spindle and the double-cone rotary box is achieved through the mounting grooves and mounting parts on both sides. The mounting grooves on both sides of the transverse spindle are circumferentially recessed, while the double-cone rotary box is provided with cylindrical mounting parts on both sides. The mounting parts can be correspondingly fitted into the mounting grooves to achieve the corresponding installation of the transverse spindle and the double-cone rotary box. The transverse spindle is fixed, while the double-cone rotary box rotates.

[0053] The horizontal spindle can be fitted with a drying heating plate and a drive mechanism. The drying heating plate itself is fixed. The drying heating plate is heated by heating wires embedded inside. The power source is achieved through wires embedded in the horizontal spindle. After the wires extend from one end of the horizontal spindle, a power supply device is installed to provide power to the heating wires inside the drying heating plate, thereby heating the drying heating plate. The structure is cleverly and reasonably designed, and the overall drying heating plate can effectively improve the drying effect without rotating.

[0054] In addition, a heat-conducting plate is also installed on the drying heating plate in this device. The design of the heat-conducting plate can increase the heating area. When the outer double cone rotary box rotates, the raw material falls on the adjacent drying heating plate and will fall on the heat-conducting plate. The heat-conducting plate is made of heat-conducting material, so the raw material can be heated through the heat-conducting plate. The heat-conducting plate can directly contact the raw material, and the overall structure is more reasonable.

[0055] Furthermore, the heat-conducting plate in this device is designed in a triangular shape, so that the raw material will not accumulate on the heat-conducting plate when it rotates, and will fall directly off the heat-conducting plate after drying.

[0056] Furthermore, the fixed horizontal spindle provides the driving power for the double cone rotary box. The two ends of the horizontal spindle are equipped with mounting seats, and drive motors are installed on the mounting seats on both sides. Drive gears are installed on the shafts of the drive motors. Importantly, a gear ring is installed on the outside of the mounting part. After the drive gear meshes with the gear ring, it can drive the double cone rotary box to rotate. The overall structure is reasonable.

[0057] The above-described specific embodiments are merely preferred embodiments of this utility model and are not intended to limit the implementation of this utility model or the scope of the claims. All equivalent changes and modifications made in accordance with the scope of protection of this utility model patent application should be included within the scope of this utility model patent application.

Claims

1. A double cone drying apparatus for carbamazepine bulk drug characterized in that: It includes a double-cone rotary box (1) and a transverse spindle (2) installed corresponding to the double-cone rotary box (1); the transverse spindle (2) is provided with circumferential recessed mounting grooves (3) on both sides, and the double-cone rotary box (1) is provided with cylindrical mounting parts (4) extending laterally on both sides. The mounting parts (4) on both sides of the double-cone rotary box (1) are fitted onto the mounting grooves (3) on both sides of the transverse spindle (2). The transverse spindle (2) is also provided with a drive mechanism on both sides, which causes the double-cone rotary box (1) to rotate on the transverse spindle (2) under the action of the drive mechanism. Several vertically arranged drying heating plates (5) are also installed on the horizontal main shaft (2). The drying heating plates (5) are set inside the double cone rotary box (1), and the outer diameter of the drying heating plates (5) gradually decreases from the middle position of the horizontal main shaft (2) to both sides.

2. Double cone drying apparatus for carbamazepine bulk drug as claimed in claim 1 wherein: The spacing between two adjacent drying heating plates (5) on the transverse main shaft (2) is the same.

3. Double cone drying apparatus for carbamazepine bulk drug as claimed in claim 1 wherein: The drying heating plate (5) is embedded with a circumferential heating wire (6), which extends and is embedded on the transverse main shaft (2), and extends out from one side of the transverse main shaft (2) and is connected to a power supply device (7); the drying heating plate (5) generates heat through the heating wire (6).

4. Double cone drying apparatus for carbamazepine bulk drug as claimed in claim 3 wherein: The drying heating plate (5) is also equipped with a horizontally extending heat-conducting plate (51). Each drying heating plate (5) has a corresponding heat-conducting plate (51) on both sides. The other end of the heat-conducting plate (51) is left with a gap between it and the adjacent drying heating plate (5). The heat-conducting plates (51) on the adjacent drying heating plates (5) are arranged alternately.

5. Double cone drying apparatus for carbamazepine bulk drug as claimed in claim 4 wherein: The heat-conducting plates (51) on the drying heating plate (5) are all triangular structures, and there are gaps between the heat-conducting plates (51) on the same drying heating plate (5).

6. Double cone drying apparatus for carbamazepine bulk drug as claimed in claim 1 wherein: The drying heating plate (5) has seven symmetrical plates arranged on the transverse main shaft (2), and the diameter of the drying heating plate (5) is set according to the size of the double cone rotary box (1).

7. A double cone drying apparatus for carbamazepine bulk drug as claimed in claim 1 wherein: The upper end of the double cone rotary box (1) is provided with a feed inlet (8) and the lower end is provided with a discharge outlet (9), and both the feed inlet (8) and the discharge outlet (9) are equipped with hinged cover plates (10).

8. A double cone drying apparatus for carbamazepine bulk drug as claimed in claim 1 wherein: The transverse main shaft (2) is also provided with mounting bases (11) at both ends, and support columns (12) are provided at the lower ends of the mounting bases (11) on both sides, while the drive mechanism is provided at the upper end of the mounting base (11).

9. A double-cone drying apparatus for carbamazepine raw material according to claim 8, characterized in that: The drive mechanism includes a drive motor (13), which is fixed on the mounting base (11). The drive motor (13) extends laterally to the inner side, and a drive gear (14) is installed at the shaft end. A gear ring (15) is also installed on the outer side of the mounting part (4) at both ends of the double cone rotary box (1). The drive gear (14) meshes with the gear ring (15). The drive gear (14) drives the gear ring (15) to rotate, thereby driving the double cone rotary box (1) to rotate.

Images