Probiotic encapsulation structures with isolated acid functionality

Abstract

The utility model relates to probiotic embedding technical field discloses probiotic embedding structure with isolated acid function, including protection shell, the front side fixedly connected with sealing plate of protection shell, the back fixedly connected with sealing ring of sealing plate, the inner wall of protection shell is provided with embedding mechanism, the right side of sealing plate is provided with protection mechanism, and the protection mechanism is used for protection, embedding mechanism includes capsule shell, and the outer wall of capsule shell is connected with the inner wall of protection shell slidingly. In the utility model, the core layer provides basic bearing for probiotic, whey protein and amino acid construct buffer environment, fructose oligosaccharide, xylo-oligosaccharide, stachydrine, create suitable living environment, composite polysaccharide layer and plant polysaccharide layer, further strengthen physical protection, phospholipid, polypeptide, targetedly resist bile destruction, form multilayer embedding effect, combine stably among each other, and it is convenient for large-scale production and storage.

Description

Technical Field

[0001] This utility model relates to the field of probiotic encapsulation technology, and in particular to a probiotic encapsulation structure with acid isolation function. Background Technology

[0002] In the complex physiological system of the human body, the gastrointestinal environment has a significant impact on the activity of probiotics. The human gastrointestinal tract has many physiological barriers, such as oral mucosal lysozyme and intestinal digestive enzymes. In particular, the highly acidic gastric juice in the intestine, with its low pH environment, poses a great challenge to the activity of probiotics. In addition, various digestive enzymes and bile acids can also seriously affect probiotics, leading to a significant increase in their mortality rate. This makes it extremely difficult for probiotics to colonize and proliferate in the colon. In order for probiotics to play a beneficial role in improving the intestinal microecology and enhancing immunity, they must be able to maintain their biological activity while passing through the gastrointestinal tract, successfully reach the intestine, and achieve adhesion and colonization. Against this background, probiotics with acid-isolating functions have emerged. These probiotics, through special physiological mechanisms and artificial modification, have the ability to resist the erosion of gastric acid and can maintain their activity to a certain extent while passing through the stomach, laying the foundation for their subsequent function in the intestine.

[0003] To further protect probiotics and improve their survival rate in the harsh environment of the gastrointestinal tract, probiotic encapsulation structures have been developed. These structures utilize specific materials to encapsulate probiotics, consisting of a wall material and the encapsulated probiotics. The wall material forms a protective barrier, isolating the probiotics from the adverse external environment. Early probiotic encapsulation structures often had poor mechanical strength and were easily degraded under physiological conditions, making it difficult to provide stable protection for probiotics for extended periods. To address this drawback, existing technologies optimize the shape and size of microcapsules to better resist the erosion of gastric acid and the action of digestive enzymes. However, in the acidic environment of the stomach, microcapsules may rupture, leading to leakage of the embedded bacteria, premature inactivation of the probiotics, and structural instability, resulting in low practicality. Utility Model Content

[0004] To overcome the above shortcomings, this invention provides a probiotic encapsulation structure with acid isolation function, which aims to improve the problem in the prior art that microcapsules rupture in the gastric acid environment, causing leakage of embedded strains, premature inactivation of probiotics, and structural instability, resulting in low practicality.

[0005] To achieve the above objectives, the present invention adopts the following technical solution: a probiotic encapsulation structure with acid isolation function, including a protective shell, a sealing plate fixedly connected to the front side of the protective shell, a sealing ring fixedly connected to the rear side of the sealing plate, an encapsulation mechanism provided on the inner wall of the protective shell, and a protective mechanism provided on the right side of the sealing plate, the protective mechanism being used for protection;

[0006] The encapsulation mechanism includes a capsule shell, the outer wall of which is slidably connected to the inner wall of a protective shell, a core layer fixedly connected to the inner wall of the capsule shell, a plurality of healthy bacteria fixedly connected to the inner wall of the core layer, a buffer layer assembly, an oligosaccharide layer assembly, a protective layer assembly, and an anti-bile lipid layer assembly on the inner wall of the capsule shell.

[0007] As a further description of the above technical solution:

[0008] The protective mechanism includes a connecting shaft, the outer wall of which is fixedly connected to the right side of the sealing plate, a hollow column is slidably connected to the outer wall of the connecting shaft, a groove is provided on the right side of the sealing plate, elastic components are provided on both the front and rear sides of the hollow column, and a drying component is provided on the inner wall of the protective shell.

[0009] As a further description of the above technical solution:

[0010] The buffer layer assembly includes whey protein, the outer wall of which is fixedly connected to the inner wall of the capsule shell, and amino acids are fixedly connected to the right side of the whey protein.

[0011] As a further description of the above technical solution:

[0012] The oligosaccharide layer assembly includes fructooligosaccharides, the outer wall of which is fixedly connected to the inner wall of the capsule shell, xylooligosaccharides are fixedly connected to the right side of which, and stachyose is fixedly connected to the right side of which.

[0013] As a further description of the above technical solution:

[0014] The protective layer assembly includes a composite polysaccharide layer, the outer wall of which is fixedly connected to the outer wall of the capsule shell, and the right side of which is fixedly connected to the right side of the plant polysaccharide layer.

[0015] As a further description of the above technical solution:

[0016] The anti-cholesterol lipid layer assembly includes phospholipids, the outer wall of which is fixedly connected to the inner wall of the capsule shell, and a polypeptide is fixedly connected to the right side of the phospholipids.

[0017] As a further description of the above technical solution:

[0018] The elastic component includes a sliding column, the front and rear sides of which are slidably connected to the front and rear sides of the hollow column, and a spring is slidably connected to the outer wall of the sliding column.

[0019] As a further description of the above technical solution:

[0020] The drying assembly includes a drying box, the bottom of which is fixedly connected to the inner wall of a protective shell, a plurality of limestone stones are fixedly connected to the inner wall of the drying box, and a cover plate is fixedly connected to the top of the limestone stones.

[0021] This utility model has the following beneficial effects:

[0022] 1. In this invention, from the inside out, healthy bacteria are initially encapsulated by the capsule shell, the core layer provides a basic support for probiotics, whey protein and amino acids construct a buffer environment to weaken the initial stimulation of gastric acid, fructooligosaccharides, xylooligosaccharides and stachyose create a suitable microenvironment for the survival of probiotics, the complex polysaccharide layer and plant polysaccharide layer further strengthen physical protection and resist the erosion of digestive juices, phospholipids and polypeptides specifically counteract bile damage, so that after the probiotics reach the intestine, they form a multi-layer encapsulation effect, and the binding between them is stable, which is convenient for large-scale production and storage.

[0023] 2. In this utility model, probiotics are placed inside the protective shell and kept dry by dehumidifying with limestone inside the drying box. Then, the shell is sealed with a sealing ring. At the same time, the hollow columns on both sides are pressed to cause the springs on both sides to contract, and the connecting shaft is inserted into the inner wall of the hollow columns on both sides. When it is necessary to remove the capsule, the hollow column is pressed to remove the capsule shell. This prevents the capsule from being exposed to the outside for a long time, which would affect its activity and enhances its practicality. Attached Figure Description

[0024] Figure 1 This is a perspective view of the front side of the protective shell of the probiotic encapsulation structure with acid isolation function proposed in this utility model.

[0025] Figure 2 This is a partial structural breakdown diagram of the sliding column of the probiotic encapsulation structure with acid isolation function proposed in this utility model.

[0026] Figure 3 This is a partial amino acid structure diagram of the probiotic encapsulation structure with acid isolation function proposed in this utility model;

[0027] Figure 4 This is a partial structural diagram of the sealing plate with a probiotic encapsulation structure that has an acid-isolation function, as proposed in this utility model.

[0028] Figure 5 This is a partial structural diagram of the limestone structure of the probiotic encapsulation structure with acid isolation function proposed in this utility model.

[0029] Legend:

[0030] 1. Protective shell; 2. Encapsulation mechanism; 201. Capsule shell; 202. Healthy bacteria; 203. Core layer; 204. Buffer layer assembly; 2041. Whey protein; 2042. Amino acids; 205. Oligosaccharide layer assembly; 2051. Fructooligosaccharides; 2052. Xylooligosaccharides; 2053. Stachyose; 206. Protective layer assembly; 2061. Complex polysaccharide layer; 2062. Plant polysaccharide layer; 207. Anti-bile lipid layer assembly; 2071. Phospholipids; 2072. Polypeptides; 3. Protective mechanism; 301. Connecting shaft; 302. Hollow column; 303. Groove; 304. Elastic component; 3041. Sliding column; 3042. Spring; 305. Drying component; 3051. Drying box; 3052. Limestone; 3053. Cover plate; 4. Sealing plate; 5. Sealing ring. Detailed Implementation

[0031] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.

[0032] Please see the appendix Figure 1 - Appendix Figure 3 An embodiment of this utility model provides a probiotic encapsulation structure with acid isolation function, including a protective shell 1, a sealing plate 4 fixedly connected to the front side of the protective shell 1, a sealing ring 5 fixedly connected to the rear side of the sealing plate 4, the sealing ring 5 further enhances the sealing effect and ensures the airtightness of the inside of the protective shell 1, an encapsulation mechanism 2 is provided on the inner wall of the protective shell 1, and a protective mechanism 3 is provided on the right side of the sealing plate 4, the protective mechanism 3 is used for protection;

[0033] The encapsulation mechanism 2 includes a capsule shell 201, the outer wall of the capsule shell 201 is slidably connected to the inner wall of the protective shell 1, a core layer 203 is fixedly connected to the inner wall of the capsule shell 201, and multiple healthy bacteria 202 are fixedly connected to the inner wall of the core layer 203. The healthy bacteria 202 are the core of the encapsulation structure and have probiotic functions. A buffer layer assembly 204 is provided on the inner wall of the capsule shell 201, an oligosaccharide layer assembly 205 is provided on the inner wall of the capsule shell 201, and a protective layer assembly 206 is provided on the inner wall of the capsule shell 201. The protective layer assembly 206 further strengthens physical protection and resists the erosion of digestive juices. An anti-bile lipid layer assembly 207 is provided on the inner wall of the capsule shell 201.

[0034] Specifically, the protective shell 1 serves as the basic support of the overall structure, accommodating and protecting the internal components. A sealing plate 4 is fixedly connected to the front of the protective shell 1, sealing the opening to prevent external substances from entering. An encapsulation mechanism 2 is located on the inner wall of the protective shell 1; this is the core functional part, used to encapsulate and protect probiotics. A protective mechanism 3 is located on the right side of the sealing plate 4, protecting against external factors that could damage the internal probiotics. The encapsulation mechanism 2 includes a capsule shell 201, the outer wall of which is slidably connected to the inner wall of the protective shell 1. The shell 201 serves as the direct encapsulation layer for probiotics, providing initial protection. The inner wall of the capsule shell 201 is fixedly connected to the core layer 203, which provides a stable carrying environment for the probiotics. The inner wall of the capsule shell 201 is provided with a buffer layer component 204, which is used to weaken external stimuli such as gastric acid. The inner wall of the capsule shell 201 is provided with an oligosaccharide layer component 205, which provides a suitable microenvironment for the survival of probiotics. The inner wall of the capsule shell 201 is provided with an anti-bile lipid layer component 207, which specifically combats bile damage and protects the activity of probiotics.

[0035] Please see the appendix Figure 3 - Appendix Figure 5 The protective mechanism 3 includes a connecting shaft 301. The outer wall of the connecting shaft 301 is fixedly connected to the right side of the sealing plate 4. A hollow column 302 is slidably connected to the outer wall of the connecting shaft 301. The hollow column 302 is used to cooperate with the connecting shaft 301 to realize the opening and closing of the protective mechanism 3. A groove 303 is provided on the right side of the sealing plate 4. Elastic components 304 are provided on both the front and rear sides of the hollow column 302. A drying component 305 is provided on the inner wall of the protective shell 1. The drying component 305 is used to maintain a dry environment inside the protective shell 1 to prevent probiotics from getting damp.

[0036] Specifically, the protective mechanism 3 includes a connecting shaft 301. The outer wall of the connecting shaft 301 is fixedly connected to the right side of the sealing plate 4. The connecting shaft 301 serves as a connecting component of the protective mechanism 3, providing fixation and support. A groove 303 is provided on the right side of the sealing plate 4, which provides sliding space for the hollow column 302. Elastic components 304 are provided on both the front and rear sides of the hollow column 302. The elastic components 304 are used to provide elastic force, enabling the hollow column 302 to automatically reset.

[0037] Please see the appendix Figure 2 - Appendix Figure 3The buffer layer assembly 204 includes whey protein 2041, the outer wall of which is fixedly connected to the inner wall of the capsule shell 201. An amino acid 2042 is fixedly connected to the right side of the whey protein 2041. The oligosaccharide layer assembly 205 includes fructooligosaccharides 2051, which provides nutritional support for probiotics. The outer wall of the fructooligosaccharides 2051 is fixedly connected to the inner wall of the capsule shell 201. Xylooligosaccharides 2052 are fixedly connected to the right side of the fructooligosaccharides 2051, and stachyose 2052 is fixedly connected to the right side of the xylooligosaccharides 2052. 53. The protective layer component 206 includes a complex polysaccharide layer 2061, the outer wall of which is fixedly connected to the outer wall of the capsule shell 201, and the right side of the complex polysaccharide layer 2061 is fixedly connected to the right side of the plant polysaccharide layer 2062. The plant polysaccharide layer 2062 further enhances the protective effect. The anti-cholesterol lipid layer component 207 includes phospholipid 2071, the outer wall of which is fixedly connected to the inner wall of the capsule shell 201, and a polypeptide 2072 is fixedly connected to the right side of the phospholipid 2071. The polypeptide 2072 further enhances the anti-cholesterol effect.

[0038] Specifically, the buffer layer component 204 includes whey protein 2041, the outer wall of which is fixedly connected to the inner wall of the capsule shell 201. Whey protein 2041, as the main component of the buffer layer, weakens the irritation of gastric acid. Amino acid 2042 is fixedly connected to the right side of whey protein 2041, further enhancing the buffering effect. The oligosaccharide layer component 205 includes fructooligosaccharide 2051, xylooligosaccharide 2052 is fixedly connected to the right side of fructooligosaccharide 2051, and stachyose 2053 is fixedly connected to the right side of xylooligosaccharide 2052. Xylooligosaccharide 2052 and stachyose 2053 together create a suitable microenvironment for the survival of probiotics. The protective layer component 206 includes a complex polysaccharide layer 2061, the outer wall of which is fixedly connected to the outer wall of the capsule shell 201. As the main component of the protective layer, the complex polysaccharide layer 2061 plays a role in resisting the erosion of digestive juices. The anti-bile lipid layer component 207 includes phospholipid 2071, the outer wall of which is fixedly connected to the inner wall of the capsule shell 201. As the main component of the anti-bile lipid layer, the phospholipid 2071 plays a role in resisting bile damage.

[0039] Please see the appendix Figure 4 - Appendix Figure 5The elastic component 304 includes a sliding column 3041, the front and rear sides of which are slidably connected to the front and rear sides of the hollow column 302. A spring 3042 is slidably connected to the outer wall of the sliding column 3041. The drying component 305 includes a drying box 3051, which serves as the main container for storing desiccant. The bottom of the drying box 3051 is fixedly connected to the inner wall of the protective shell 1. Multiple limestone stones 3052 are fixedly connected to the inner wall of the drying box 3051. A cover plate 3053 is fixedly connected to the top of the limestone stones 3052. The cover plate 3053 is used to close the drying box 3051 and prevent the desiccant from scattering.

[0040] Specifically, the elastic component 304 includes a sliding column 3041, the front and rear sides of which are slidably connected to the front and rear sides of the hollow column 302. The sliding column 3041 serves as a supporting component of the elastic component 304, playing a role in fixing and sliding. A spring 3042 is slidably connected to the outer wall of the sliding column 3041, and the spring 3042 provides elastic force, enabling the hollow column 302 to automatically reset. The drying component 305 includes a drying box 3051, the bottom of which is fixedly connected to the inner wall of the protective shell 1. Multiple limestone stones 3052 are fixedly connected to the inner wall of the drying box 3051, and the limestone stones 3052 serve as desiccants to absorb moisture inside the protective shell 1.

[0041] Working principle: From the inside out, healthy bacteria 202 are initially encapsulated by the capsule shell 201. The core layer 203 provides a basic support for probiotics. Whey protein 2041 and amino acids 2042 construct a buffer environment to weaken the initial stimulation of gastric acid. Fructooligosaccharides 2051, xylooligosaccharides 2052, and stachyose 2053 create a suitable microenvironment for the survival of probiotics. The complex polysaccharide layer 2061 and the plant polysaccharide layer 2062 further strengthen physical protection and resist the erosion of digestive juices. Phospholipids 2071 and polypeptides 2072 specifically combat bile damage, allowing probiotics to form a multi-layer encapsulation effect after reaching the intestines. The inter-bacteria are stably bound together, which facilitates large-scale production and storage.

[0042] The probiotics are placed inside the protective shell 1 and dehumidified by the limestone 3052 inside the drying box 3051, keeping it dry. Then, it is sealed by the sealing ring 5. At the same time, the hollow columns 302 on both sides are pressed, causing the springs 3042 on both sides to contract. The connecting shaft 301 is inserted into the inner wall of the hollow columns 302 on both sides. When it is necessary to remove it, press the hollow column 302 to remove the capsule shell 201. This prevents the capsule from being exposed to the outside for a long time, which would affect its activity and enhances its practicality.

[0043] Finally, it should be noted that the above description is only a preferred embodiment of the present utility model and is not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.

Claims

1. A probiotic encapsulation structure with acid-isolating function, comprising a protective shell (1), characterized in that: A sealing plate (4) is fixedly connected to the front side of the protective shell (1), and a sealing ring (5) is fixedly connected to the rear side of the sealing plate (4). An embedding mechanism (2) is provided on the inner wall of the protective shell (1), and a protective mechanism (3) is provided on the right side of the sealing plate (4). The protective mechanism (3) is used for protection. The encapsulation mechanism (2) includes a capsule shell (201), the outer wall of the capsule shell (201) is slidably connected to the inner wall of the protective shell (1), a core layer (203) is fixedly connected to the inner wall of the capsule shell (201), a plurality of healthy bacteria (202) are fixedly connected to the inner wall of the core layer (203), a buffer layer assembly (204) is provided on the inner wall of the capsule shell (201), an oligosaccharide layer assembly (205) is provided on the inner wall of the capsule shell (201), a protective layer assembly (206) is provided on the inner wall of the capsule shell (201), and an anti-bile lipid layer assembly (207) is provided on the inner wall of the capsule shell (201).

2. The probiotic encapsulation structure with acid-isolating function according to claim 1, characterized in that: The protective mechanism (3) includes a connecting shaft (301), the outer wall of the connecting shaft (301) is fixedly connected to the right side of the sealing plate (4), a hollow column (302) is slidably connected to the outer wall of the connecting shaft (301), a groove (303) is provided on the right side of the sealing plate (4), elastic components (304) are provided on both the front and rear sides of the hollow column (302), and a drying component (305) is provided on the inner wall of the protective shell (1).

3. The probiotic encapsulation structure with acid-isolating function according to claim 1, characterized in that: The buffer layer assembly (204) includes whey protein (2041), the outer wall of which is fixedly connected to the inner wall of the capsule shell (201), and an amino acid (2042) is fixedly connected to the right side of the whey protein (2041).

4. The probiotic encapsulation structure with acid-isolating function according to claim 1, characterized in that: The oligosaccharide layer assembly (205) includes fructooligosaccharide (2051), the outer wall of which is fixedly connected to the inner wall of the capsule shell (201), xylooligosaccharide (2052) is fixedly connected to the right side of which is stachyose (2053).

5. The probiotic encapsulation structure with acid-isolating function according to claim 1, characterized in that: The protective layer assembly (206) includes a complex polysaccharide layer (2061), the outer wall of which is fixedly connected to the outer wall of the capsule shell (201), and the right side of which is fixedly connected to the right side of the plant polysaccharide layer (2062).

6. The probiotic encapsulation structure with acid-isolating function according to claim 1, characterized in that: The anti-cholesterol lipid layer assembly (207) includes phospholipids (2071), the outer wall of which is fixedly connected to the inner wall of the capsule shell (201), and a polypeptide (2072) is fixedly connected to the right side of the phospholipids (2071).

7. The probiotic encapsulation structure with acid-isolating function according to claim 2, characterized in that: The elastic component (304) includes a sliding column (3041), the front and rear sides of which are slidably connected to the front and rear sides of the hollow column (302), and a spring (3042) is slidably connected to the outer wall of the sliding column (3041).

8. The probiotic encapsulation structure with acid-isolating function according to claim 2, characterized in that: The drying assembly (305) includes a drying box (3051), the bottom of which is fixedly connected to the inner wall of the protective shell (1), and a plurality of limestones (3052) are fixedly connected to the inner wall of the drying box (3051), and a cover plate (3053) is fixedly connected to the top of the limestones (3052).

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