A tangential flow filtration membrane pack
By introducing independent inlet, concentration, and liquid exchange components into the tangential flow filtration membrane package, and using buffer solution to mix with the solution to be concentrated, the problem of low concentration and liquid exchange efficiency is solved, and a more efficient concentration and liquid exchange process is achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- SAIPU (HANGZHOU) FILTRATION TECHNOLOGY CO LTD
- Filing Date
- 2025-06-30
- Publication Date
- 2026-07-14
AI Technical Summary
Existing tangential flow filtration membrane packs have low concentration and liquid exchange efficiency, resulting in long process times.
Design a tangential flow filtration membrane package comprising a liquid inlet assembly, a concentration assembly, and a liquid exchange assembly. Concentration and liquid exchange are performed through an independent channel system. Buffer solution is used to mix with the liquid to be concentrated in the liquid exchange channel, and environmental parameters are adjusted to improve concentration efficiency.
It improves concentration efficiency and liquid exchange efficiency, and shortens process time.
Smart Images
Figure CN224485111U_ABST
Abstract
Description
Technical Field
[0001] This application relates to the fields of biological treatment and filtration technology, specifically to a tangential flow filtration membrane pack. Background Technology
[0002] In the biopharmaceutical industry, tangential flow filtration technology is widely used, especially for the filtration, concentration, and dialysis of fluids containing large protein molecules. Tangential flow filtration differs from traditional filtration in that the liquid flow direction is perpendicular to the filtration direction, effectively preventing the formation of filter cake and gel layers, thereby improving filtration efficiency and stability.
[0003] In related technologies, tangential flow filtration membrane packs typically consist only of a stacked feed layer and a concentration layer. The residual liquid discharged from the feed layer is concentrated in the concentration layer to form a concentrate. This concentrate is then returned to the feed layer via external piping, pumps, and tanks, during which new buffer solution is added for liquid exchange. This design results in low concentration and liquid exchange efficiency and a long processing time. Utility Model Content
[0004] In view of this, this application provides a tangential flow filtration membrane package to solve or improve the problems of low concentration and liquid exchange efficiency and long processing time in the process.
[0005] This application provides a tangential flow filtration membrane pack, comprising: a membrane pack body, wherein a sealing portion is provided on the periphery of the membrane pack body; the membrane pack body includes:
[0006] Multiple liquid inlet components, each of which has a liquid inlet screen;
[0007] A concentration component has a concentration screen with concentration membranes on both sides of the concentration screen, and liquid inlet components on both sides of the concentration component.
[0008] The liquid exchange assembly has a liquid exchange screen, on both sides of which are provided a liquid exchange membrane, and on both sides of the liquid exchange assembly are provided the liquid inlet assembly;
[0009] The membrane package body is provided with an inlet channel, an outlet channel, a liquid exchange channel, and a filtrate channel. The inlet channel is only connected to the inlet screen, the outlet channel is only connected to the inlet screen, the liquid exchange channel is only connected to the liquid exchange screen, and the filtrate channel is only connected to the concentration screen.
[0010] In this embodiment, the solution to be concentrated is input through the inlet channel, which is connected to the inlet screen. The solution enters the inlet screen through the inlet channel and flows from one side of the inlet channel to the other side of the outlet channel. During this process, small molecules in the solution pass through the concentration membrane and enter the concentration screen to concentrate the solution. The concentrated product is output from the outlet channel. During the concentration process, a buffer solution is added to the exchange channel. The buffer solution passes through the exchange channel and enters the exchange screen between the exchange membranes. The exchange membrane is a one-way membrane, and the buffer solution can only enter the inlet screen through the exchange screen. The buffer solution mixes with the solution to be concentrated in the inlet screen, adjusting the environment of the solution to be concentrated in the inlet screen, such as pH value and ionic strength. Adjusting the environment of the solution to be concentrated can improve the concentration effect. The buffer solution enters the inlet screen through the exchange membrane, and can simultaneously fill the inlet screen with buffer solution during the concentration process, improving the concentration efficiency.
[0011] In one optional embodiment, the liquid inlet assembly is provided with a first through hole corresponding to the liquid inlet channel, the liquid outlet channel, the filtrate channel and the liquid exchange channel; the concentration assembly is provided with a second through hole corresponding to the liquid inlet channel, the liquid outlet channel, the filtrate channel and the liquid exchange channel; and the liquid exchange assembly is provided with a third through hole corresponding to the liquid inlet channel, the liquid outlet channel, the filtrate channel and the liquid exchange channel.
[0012] In one optional embodiment, the third through hole on the liquid exchange screen includes a liquid exchange inlet corresponding to the liquid exchange channel, the liquid exchange inlet is connected to the liquid exchange screen, and a third sealing ring is provided on the periphery of the remaining third through holes.
[0013] In one optional embodiment, the first through hole on the liquid inlet assembly includes a liquid inlet corresponding to the liquid inlet channel and a liquid outlet corresponding to the liquid outlet channel. Both the liquid inlet and the liquid outlet are connected to the liquid inlet screen, and a first sealing ring is provided on the periphery of the remaining first through holes.
[0014] In one optional embodiment, the second through hole on the concentration screen includes a filtrate outlet corresponding to the filtrate channel, the filtrate outlet being connected to the concentration screen, and a second sealing ring being provided around the remaining second through holes.
[0015] In one optional embodiment, sealing rings are provided on the periphery of the inlet screen, the concentration screen, and the liquid exchange screen.
[0016] In one optional embodiment, the sealing ring on the liquid exchange screen is integrally formed with the third sealing ring;
[0017] And / or, the sealing ring on the liquid inlet screen is integrally formed with the first sealing ring;
[0018] And / or, the sealing ring on the concentration screen is integrally formed with the second sealing ring.
[0019] In one optional embodiment, the inlet channel, the outlet channel, the liquid exchange channel, and the filtrate channel are located near the side of the membrane pack body, and the inlet channel and the outlet channel are located on opposite sides of the membrane pack body along a first direction, wherein the first direction is the length direction of the membrane pack body.
[0020] In one optional embodiment, the fluid exchange channel and the fluid inlet channel are on the same side of the membrane body along the first direction;
[0021] Alternatively, the liquid exchange channel and the liquid outlet channel are arranged on the membrane body along the first direction.
[0022] In one optional embodiment, a drain channel is provided on the membrane body, the drain channel is only connected to the liquid exchange screen, the liquid exchange channel is provided on only one side of the membrane body, and the drain channel and the liquid exchange channel are respectively provided on opposite sides of the membrane body along the first direction. Attached Figure Description
[0023] To more clearly illustrate the technical solutions in the specific embodiments of this application or the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this application. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.
[0024] Figure 1 This is a schematic diagram of the structure of a tangential flow filtration membrane pack according to an embodiment of this application;
[0025] Figure 2 for Figure 1 A cross-sectional view along AA when the main body of the membrane package is not encapsulated;
[0026] Figure 3 for Figure 1 A cross-sectional view along BB when the main body of the membrane package is not encapsulated;
[0027] Figure 4 for Figure 1 A cross-sectional view along AA after the main body of the membrane package is sealed;
[0028] Figure 5 for Figure 1 Schematic diagram of the liquid inlet assembly, concentration assembly, and liquid exchange assembly;
[0029] Figure 6 This is an unfolded view of another form of a tangential flow filtration membrane package according to an embodiment of this application;
[0030] Figure 7 for Figure 6 Schematic diagram of the structure of the inlet screen, the liquid exchange screen, and the concentration screen;
[0031] Figure 8 This is a schematic diagram of another form of inlet screen, liquid exchange screen, and concentration screen in a tangential flow filtration membrane package according to an embodiment of this application;
[0032] Figure 9 This is a schematic diagram of the structure of another type of inlet screen, liquid exchange screen and concentration screen in a tangential flow filtration membrane package according to an embodiment of this application.
[0033] Explanation of reference numerals in the attached figures:
[0034] 1. Membrane pack body; 101. Liquid inlet assembly; 1011. Liquid inlet screen; 1012. First through hole; 1013. Liquid inlet; 1014. Liquid outlet; 102. Concentration assembly; 1021. Concentration screen; 1022. Second through hole; 1023. Concentration membrane; 1024. Filtrate outlet; 103. Liquid exchange assembly; 1031. Liquid exchange screen; 1032. Third through hole; 1033. Liquid exchange membrane; 1034. Liquid exchange inlet; 104. Liquid inlet channel; 105. Liquid outlet channel; 106. Liquid exchange channel; 107. Filtrate channel; 2. Sealing part; 3. First sealing ring; 4. Second sealing ring; 5. Third sealing ring; 6. Sealing ring; X, First direction; Y, Second direction. Detailed Implementation
[0035] To make the objectives, technical solutions, and advantages of the embodiments of this application clearer, the technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.
[0036] In the description of this application, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this application. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.
[0037] In the description of this application, it should be noted that, unless otherwise expressly specified and limited, the terms "installation," "connection," and "linking" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; or they can refer to the internal communication between two components. Those skilled in the art can understand the specific meaning of the above terms in this application based on the specific circumstances.
[0038] In the biopharmaceutical industry, tangential flow filtration technology is widely used, especially for the filtration, concentration, and dialysis of fluids containing large protein molecules. Tangential flow filtration differs from traditional filtration in that the liquid flow direction is perpendicular to the filtration direction, effectively preventing the formation of filter cake and gel layers, thereby improving filtration efficiency and stability.
[0039] In related technologies, tangential flow filtration membrane packages typically consist only of a stacked inlet layer and a concentration layer. The residual liquid discharged from the inlet layer is concentrated in the concentration layer to form a concentrate. This concentrate is then returned to the inlet layer via external piping, pumps, and tanks, during which new buffer solution is added for liquid exchange. This design results in low concentration and liquid exchange efficiency and long processing times. Therefore, this application provides a tangential flow filtration membrane package to solve or improve the problems of low concentration and liquid exchange efficiency and long processing times.
[0040] The following is combined Figures 1 to 9 The embodiments of this application are described as shown.
[0041] According to an embodiment of this application, a tangential flow filtration membrane package is provided, comprising: a membrane package body 1, wherein a sealing portion 2 is provided on the periphery of the membrane package body 1; the membrane package body 1 includes: a plurality of liquid inlet components 101, at least one concentration component 102 and at least one liquid exchange component 103.
[0042] Specifically, each liquid inlet component 101 has a liquid inlet screen 1011; the concentration component 102 has a concentration screen 1021, and concentration membranes 1023 are provided on both sides of the concentration screen 1021, and each concentration component 102 has a liquid inlet component 101 on both sides; the liquid exchange component 103 has a liquid exchange screen 1031, and liquid exchange membranes 1033 are provided on both sides of the liquid exchange screen 1031, and each liquid exchange component 103 has a liquid inlet component 101 on both sides.
[0043] The membrane body 1 is provided with an inlet channel 104, an outlet channel 105, a liquid exchange channel 106, and a filtrate channel 107. The inlet channel 104 is only connected to the inlet screen 1011, the outlet channel 105 is only connected to the inlet screen 1011, the liquid exchange channel 106 is only connected to the liquid exchange screen 1031, and the filtrate channel 107 is only connected to the concentration screen 1021.
[0044] In this embodiment, the liquid to be concentrated is input through the inlet channel 104, which is connected to the inlet screen 1011. The liquid to be concentrated enters the inlet screen 1011 through the inlet channel 104. During the flow of the liquid to be concentrated through the inlet screen 1011, that is, from one side of the inlet channel 104 to the other side of the outlet channel 105, small molecules in the liquid to be concentrated pass through the concentration membrane 1023 and enter the concentration screen 1021, thus concentrating the liquid. The concentrated product is output from the outlet channel 105. During the concentration process, buffer solution is added to the liquid exchange channel 106 to buffer the liquid. The buffer solution enters the exchange screen 1031 between the exchange membranes 1033 through the exchange channel 106. Under the action of transmembrane pressure, the buffer solution passes through the exchange membrane 1033 and enters the inlet screen 1011. The buffer solution mixes with the solution to be concentrated in the inlet screen 1011, and new buffer solution is added. The environment of the solution to be concentrated in the inlet screen 1011, such as pH value and ionic strength, can also be adjusted. By adjusting the environment of the solution to be concentrated, the concentration effect can be improved. The buffer solution enters the inlet screen 1011 through the exchange membrane 1033, and the buffer solution can be filled into the inlet screen 1011 at the same time during the concentration process, thereby improving the concentration efficiency.
[0045] In some embodiments, the liquid inlet assembly 101 is provided with a first through hole 1012 corresponding to the liquid inlet channel 104, the liquid outlet channel 105, the filtrate channel 107, and the liquid exchange channel 106; the concentration assembly 102 is provided with a second through hole 1022 corresponding to the liquid inlet channel 104, the liquid outlet channel 105, the filtrate channel 107, and the liquid exchange channel 106; and the liquid exchange assembly 103 is provided with a third through hole 1032 corresponding to the liquid inlet channel 104, the liquid outlet channel 105, the filtrate channel 107, and the liquid exchange channel 106.
[0046] Specifically, the membrane body 1 is stacked with multiple inlet components 101, at least one concentration component 102, and at least one exchange component 103. This includes multiple inlet screens 1011, concentration screens 1021, concentration membranes 1023, exchange screens 1031, and exchange membranes 1033. To facilitate the feeding of the solution to be concentrated into the multiple inlet screens 1011, the buffer solution is fed into the multiple exchange screens 1031. The concentrated solution is discharged from the multiple inlet screens 1011, and the filtrate after passing through the concentration membrane 1023 is discharged from the multiple concentration screens 1021. Each inlet screen 1011, concentration screen 1021, concentration membrane 1023, exchange screen 1031, and exchange membrane 1033 is provided with corresponding through holes. When stacked, they form an inlet channel 104, an outlet channel 105, an exchange channel 106, and a filtrate channel 107. For ease of differentiation, the liquid inlet assembly 101 is provided with a first through hole 1012 corresponding to the liquid inlet channel 104, liquid outlet channel 105, filtrate channel 107 and liquid exchange channel 106; the concentration assembly 102 is provided with a second through hole 1022 corresponding to the liquid inlet channel 104, liquid outlet channel 105, filtrate channel 107 and liquid exchange channel 106; and the liquid exchange assembly 103 is provided with a third through hole 1032 corresponding to the liquid inlet channel 104, liquid outlet channel 105, filtrate channel 107 and liquid exchange channel 106.
[0047] In some embodiments, the first through hole 1012 on the liquid inlet assembly 101 includes a liquid inlet 1013 corresponding to the liquid inlet channel 104 and a liquid outlet 1014 corresponding to the liquid outlet channel 105. Both the liquid inlet 1013 and the liquid outlet 1014 are connected to the liquid inlet screen 1011, and the periphery of the remaining first through holes 1012 is provided with a first sealing ring 3.
[0048] Specifically, the liquid inlet assembly 101 is provided with a plurality of first through holes 1012. The function of the liquid inlet assembly 101 is to introduce the liquid to be concentrated and spread it on the liquid inlet screen 1011. A concentration membrane 1023 is provided on one side of the liquid inlet screen 1011. The liquid to be concentrated enters the liquid inlet screen 1011 horizontally. The pressure on both sides of the concentration membrane 1023 is different, which filters out small molecules and liquids smaller than the pore size of the concentration membrane 1023 in the liquid to be concentrated. The unfiltered liquid to be concentrated is discharged. Therefore, the first through holes 1012 on the liquid inlet assembly 101 need to include a liquid inlet 1013 corresponding to the liquid inlet channel 104 and a liquid outlet 1014 corresponding to the liquid outlet channel 105. Both the liquid inlet 1013 and the liquid outlet 1014 are connected to the liquid inlet screen 1011. Meanwhile, in order to prevent the concentrate from directly entering the filtrate channel 107 and the liquid exchange channel 106, making it difficult to recover or increase the flow path, the remaining first through holes 1012 need to be provided with first sealing rings 3 around their periphery.
[0049] In some embodiments, the second through hole 1022 on the concentrating screen 1021 includes a filtrate outlet 1024 corresponding to the filtrate channel 107, the filtrate outlet 1024 is connected to the concentrating screen 1021, and the periphery of the remaining second through holes 1022 is provided with a second sealing ring 4.
[0050] Specifically, a concentration membrane 1023 is provided on both sides of the concentration screen 1021 to receive small molecules and liquids that pass through the concentration membrane 1023. Since the filtered filtrate needs to be discharged, the second through hole 1022 on the concentration screen 1021 corresponding to the filtrate channel 107 is set as the filtrate outlet 1024, which is connected to the filtrate channel 107. The remaining second through holes 1022 are sealed with a second sealing ring 4 to prevent the concentrate or buffer solution from short-circuiting and directly entering the filtrate screen and being discharged through the filtrate channel 107, which would result in the waste of the concentrate and buffer solution.
[0051] In some embodiments, the third through hole 1032 on the liquid exchange screen 1031 includes a liquid exchange inlet 1034 corresponding to the liquid exchange channel 106. The liquid exchange inlet 1034 communicates with the liquid exchange screen 1031, and a third sealing ring 5 is provided on the periphery of the remaining third through holes 1032.
[0052] Specifically, the buffer exchange screen 1031 is provided with multiple third through holes 1032. In order to introduce the buffer solution into the buffer exchange screen 1031, the third through hole 1032 corresponding to the buffer exchange channel 106 needs to be set as the buffer exchange inlet 1034. The buffer solution can be introduced into the buffer exchange screen 1031 through the buffer exchange channel 106. In order to improve the distribution effect of the buffer solution, the remaining third through holes 1032 are provided with third sealing rings 5. At this time, the buffer solution has no other outflow channel and can only enter the inlet screen 1011 through the buffer exchange membrane 1033.
[0053] In some embodiments, sealing rings 6 are provided around the liquid inlet screen 1011, the concentration screen 1021, and the liquid exchange screen 1031.
[0054] Specifically, the first sealing ring 3, the second sealing ring 4, and the third sealing ring 5 prevent short circuits between different fluids (e.g., concentrate, buffer solution, filtrate) at the inlet channel 104, outlet channel 105, filtrate channel 107, and exchange channel 106. The outer edges of the stacked inlet assembly 101, concentration assembly 102, and exchange assembly 103 are sealed with adhesive, which to some extent prevents mixing of different flows at the edges of the inlet screen 1011, concentration screen 1021, and exchange screen 1031. However, to further improve sealing, sealing rings 6 can be provided around the periphery of the inlet screen 1011, concentration screen 1021, and exchange screen 1031.
[0055] Specifically, the first sealing ring 3, the second sealing ring 4, the third sealing ring 5, and the sealing ring 6 can all be formed by using liquid adhesive to penetrate and cure the screen, or they can be formed by welding materials placed on both sides of the screen.
[0056] In some embodiments, the sealing ring 6 on the liquid exchange screen 1031 is integrally formed with the third sealing ring 5;
[0057] And / or, the sealing ring 6 on the liquid inlet screen 1011 is integrally set with the first sealing ring 3;
[0058] And / or, the sealing ring 6 on the concentration screen 1021 is integrally set with the second sealing ring 4.
[0059] In some embodiments, the inlet channel 104, outlet channel 105, liquid exchange channel 106, and filtrate channel 107 are located near the side of the membrane body 1. The inlet channel 104 and outlet channel 105 are disposed on opposite sides of the membrane body 1 along a first direction X, wherein the first direction X is the length direction of the membrane body 1.
[0060] Specifically, the inlet channel 104 is used to feed the liquid to be concentrated into the inlet port 1013 of the inlet screen 1011 and discharge it from the outlet port 1014 of the inlet screen 1011 into the outlet channel 105. The inlet channel 104 and the outlet channel 105 are respectively provided on opposite sides of the filter membrane pack in the length direction, which can ensure that the liquid to be concentrated has the longest flow path in the inlet screen 1011, so as to achieve concentration and liquid replacement for a longer time and improve filtration efficiency.
[0061] In some embodiments, the fluid exchange channel 106 and the fluid inlet channel 104 are on the same side of the membrane body 1 along the first direction X;
[0062] Alternatively, the liquid exchange channel 106 and the liquid outlet channel 105 are arranged on the membrane body 1 along the first direction X.
[0063] Specifically, by sharing the same side between the buffer solution channel 106 and the inlet channel 104, and because the buffer solution and the concentrate flow in the same direction, a forward-pushing and backward-rushing effect can be created. This helps to more evenly propel the concentrate through the membrane surface, improving filtration efficiency and flux. Secondly, this design helps maintain the stability of transmembrane pressure, ensuring a smooth filtration process. It also simplifies system design and operation, reducing equipment complexity and maintenance costs.
[0064] Specifically, by setting the liquid exchange channel 106 and the liquid outlet channel 105 on the same side, the countercurrent system can greatly improve the mass transfer efficiency because the countercurrent flow helps to maintain a higher concentration gradient, thereby more effectively diluting the higher concentration liquid to be concentrated near the liquid outlet 1014 and reducing the concentration polarization phenomenon on the membrane surface. Finally, it can also enhance the effective control of membrane fouling and extend the service life of the membrane.
[0065] Specifically, the filtrate channel 107 and the liquid exchange channel 106 are located on opposite sides of the membrane body 1 along the first direction X.
[0066] Specifically, both sides of the membrane body 1 can be provided with liquid exchange channels 106.
[0067] Specifically, filtrate channels 107 can be provided on both sides of the membrane body 1.
[0068] In some embodiments, the filtrate channel 107 and the liquid exchange channel 106 are respectively disposed on opposite sides of the membrane body 1 along the first direction X.
[0069] In some embodiments, a drain channel is provided on the membrane body 1, which is only connected to the liquid exchange screen 1031. The liquid exchange channel 106 is provided on only one side of the membrane body 1, and the drain channel and the liquid exchange channel 106 are respectively provided on opposite sides of the membrane body 1 along the first direction.
[0070] Specifically, the membrane pack body 1 may also be provided with an additional drainage channel. The drainage channel is only connected to the liquid exchange screen 1031, and the fluid in the liquid exchange screen 1031 can be discharged from the drainage channel. The advantage of this is that it is easy to control the flux of the buffer solution through the liquid exchange membrane 1033 and to adjust the liquid exchange process inside the filter membrane pack.
[0071] Combination Figures 1 to 9 A comprehensive explanation of all the above-mentioned plans is provided.
[0072] like Figures 1 to 5 As shown, the membrane body 1 of the filter membrane pack is provided with an inlet channel 104, an outlet channel 105, a filtrate channel 107 and a liquid exchange channel 106. The inlet channel 104 and the liquid exchange channel 106 are located on one side, and the outlet channel 105 and the filtrate channel 107 are located on the other side. The membrane body 1 includes an inlet assembly 101, a liquid exchange assembly 103 and a concentration assembly 102 stacked together, and is sealed by the outer sealing part 2.
[0073] The liquid inlet assembly 101 includes a liquid inlet screen 1011 with four first through holes 1012. Each first through hole 1012 includes an inlet 1013 corresponding to the liquid inlet channel 104 and an outlet 1014 corresponding to the liquid outlet channel 105. Two first sealing rings 3 are provided around the outer periphery of the other two first through holes 1012. A sealing ring 6 is provided on the outer edge of the liquid inlet screen 1011. The sealing ring 6 is integrally formed with the first sealing ring 3 and has an overlapping area. The surfaces of the sealing ring 6 and the first sealing ring 3 are flat, providing an elastic seal with the adjacent concentration membrane 1023 and exchange membrane 1033.
[0074] The concentration assembly 102 includes a concentration screen 1021 with four second through holes 1022. Each second through hole 1022 includes a filtrate outlet 1024 corresponding to the filtrate channel 107. Three other second through holes 1022 have second sealing rings 4 around their outer peripheries. A sealing ring 6 is provided on the outer edge of the concentration screen 1021, integrally formed with the second sealing rings 4 and having an overlapping area. The concentration screen 1021 is sealed to the concentration membranes 1023 on both sides via the sealing rings 6 and the second sealing rings 4, which can be achieved through bonding or welding.
[0075] The fluid exchange assembly 103 includes a fluid exchange screen 1031 with four third through holes 1032. Each third through hole 1032 includes a fluid exchange inlet 1034 corresponding to the fluid exchange channel 106. Three third sealing rings 5 are provided around the outer periphery of the other three third through holes 1032. A sealing ring 6 is provided on the outer edge of the fluid exchange screen 1031. The sealing ring 6 and the third sealing ring 5 are integrally formed and have overlapping areas. The fluid exchange screen 1031 is sealed to the fluid exchange membranes 1033 on both sides through the sealing rings 6 and the third sealing rings 5, which can be achieved by bonding or welding.
[0076] The solution to be concentrated is input through the inlet channel 104 and enters the inlet screen 1011 through the inlet port 1013. During the flow of the solution through the inlet screen 1011 (from one side of the inlet channel 104 to the other side of the outlet channel 105), small molecules and liquid in the solution pass through the concentrating membrane 1023 into the concentrating screen 1021 and are discharged from the filtrate outlet 1024 into the filtrate channel 107. The concentrated product is output from the outlet channel 105. During the concentration process, a buffer solution is added to the liquid exchange channel 106. The buffer solution passes through the liquid exchange channel 106... 06. The buffer solution enters the exchange screen 1031 between the exchange membranes 1033. Under the action of transmembrane pressure, the buffer solution passes through the exchange membrane 1033 and enters the inlet screen 1011. The buffer solution mixes with the solution to be concentrated in the inlet screen 1011, and new buffer solution is added. The environment of the solution to be concentrated in the inlet screen 1011 can also be adjusted, such as pH value and ionic strength. By adjusting the environment of the solution to be concentrated, the concentration effect can be improved. The buffer solution enters the inlet screen 1011 through the exchange membrane 1033, and can simultaneously fill the inlet screen 1011 with buffer solution during the concentration process, thereby improving the concentration efficiency.
[0077] The buffer exchange membrane 1033 can be an ultrafiltration membrane, microfiltration membrane, non-woven fabric, or any other porous material. The buffer exchange membrane 1033 can fully distribute the buffer solution on the membrane before it enters the concentration sieve 1021, which can significantly improve the concentration and buffer exchange effect.
[0078] like Figures 6 to 7 As shown, sealing rings 6 are not provided on the inlet screen 1011, the concentration screen 1021, and the liquid exchange screen 1031.
[0079] In another embodiment, combined with appendix Figure 8The membrane body 1 of the filter membrane pack is provided with 5 inlet channels 104, 5 outlet channels 105, 4 filtrate channels 107, and 4 exchange channels 106. Correspondingly, the inlet screen 1011 is provided with 18 first through holes 1012, each of which includes 5 inlet ports 1013 and 5 outlet ports 1014. The remaining first through holes 1012 are surrounded by first sealing rings 3. The exchange membrane 1033 or the concentration membrane 1023... The size is the same as the inlet screen 1011, and it is sealed to the liquid exchange membrane 1033 or the concentration membrane 1023 on both sides of the inlet screen 1011 by a first sealing ring 3. The concentration screen 1021 is provided with 18 second through holes 1022, including 4 filtrate outlets 1024. The periphery of the remaining second through holes 1022 is provided with second sealing rings 4, which are sealed to the concentration membranes 1023 on both sides of the concentration screen 1021. The liquid exchange screen 1031 is provided with 18 third through holes 1032, including 4 liquid exchange inlets 1034. The periphery of the remaining third through holes 1032 is provided with third sealing rings 5, which are sealed to the liquid exchange membranes 1033 on both sides of the liquid exchange screen 1031.
[0080] The inlet channel 104 and the liquid exchange channel 106 are located on the same side, while the outlet channel 105 and the filtrate channel 107 are located on opposite sides along the length of the membrane. Alternatively, the inlet channel 104 and the filtrate channel 107 can be located on the same side, while the outlet channel 105 and the liquid exchange channel 106 can be located on opposite sides along the length of the membrane.
[0081] like Figure 9 As shown, the membrane body 1 of the filter membrane pack is provided with 3 liquid inlet channels 104, 3 liquid outlet channels 105, 6 filtrate channels 107 and 6 liquid exchange channels 106. Correspondingly, the liquid inlet screen 1011, the concentration screen 1021 and the liquid exchange screen 1031 are provided with 3 liquid inlets 1013, 3 liquid outlets 1014, 6 filtrate outlets 1024 and 6 liquid exchange inlets 1034. The liquid inlet screen 1011, the concentration screen 1021 and the liquid exchange screen 1031 are not provided with sealing rings 6.
[0082] The inlet channel 104 and outlet channel 105 are located on two opposite sides along the length of the membrane pack, and each side is provided with a liquid exchange channel 106 and a filtrate channel 107.
[0083] like Figure 9 As shown, the structure of the filter membrane pack has not changed; only during use, the three liquid exchange channels 106 on one side are used as drainage channels.
[0084] Although embodiments of this application have been described in conjunction with the accompanying drawings, those skilled in the art can make various modifications and variations without departing from the spirit and scope of this application, and such modifications and variations all fall within the scope defined by the appended application.
Claims
1. A tangential flow filtration membrane package, characterized in that, include: A membrane-wrapped body (1) is provided with a sealing part (2) on its periphery; The membrane-covered body (1) includes: Multiple liquid inlet components (101), each of which has a liquid inlet screen (1011); The concentration component (102) has a concentration screen (1021) with concentration membranes (1023) on both sides of the concentration screen (1021) and liquid inlet components (101) on both sides of the concentration component (102). The liquid exchange assembly (103) has a liquid exchange screen (1031), and liquid exchange membranes (1033) are provided on both sides of the liquid exchange screen (1031). The liquid exchange assembly (103) is provided with liquid inlet assembly (101) on both sides. The membrane body (1) is provided with an inlet channel (104), an outlet channel (105), a liquid exchange channel (106), and a filtrate channel (107). The inlet channel (104) is only connected to the inlet screen (1011), the outlet channel (105) is only connected to the inlet screen (1011), the liquid exchange channel (106) is only connected to the liquid exchange screen (1031), and the filtrate channel (107) is only connected to the concentration screen (1021).
2. The tangential flow filtration membrane pack according to claim 1, characterized in that, The liquid inlet assembly (101) is provided with a first through hole (1012) corresponding to the liquid inlet channel (104), the liquid outlet channel (105), the filtrate channel (107), and the liquid exchange channel (106). The concentration assembly (102) is provided with a second through hole (1022) corresponding to the liquid inlet channel (104), the liquid outlet channel (105), the filtrate channel (107), and the liquid exchange channel (106). The liquid exchange assembly (103) is provided with a third through hole (1032) corresponding to the liquid inlet channel (104), the liquid outlet channel (105), the filtrate channel (107), and the liquid exchange channel (106).
3. The tangential flow filtration membrane pack according to claim 2, characterized in that, The third through hole (1032) on the liquid exchange screen (1031) includes a liquid exchange inlet (1034) corresponding to the liquid exchange channel (106). The liquid exchange inlet (1034) is connected to the liquid exchange screen (1031). The remaining third through holes (1032) are provided with a third sealing ring (5) around their periphery.
4. The tangential flow filtration membrane pack according to claim 3, characterized in that, The first through hole (1012) on the liquid inlet assembly (101) includes a liquid inlet (1013) corresponding to the liquid inlet channel (104) and a liquid outlet (1014) corresponding to the liquid outlet channel (105). The liquid inlet (1013) and the liquid outlet (1014) are both connected to the liquid inlet screen (1011). The remaining first through holes (1012) are provided with a first sealing ring (3) on their periphery.
5. The tangential flow filtration membrane pack according to claim 4, characterized in that, The second through hole (1022) on the concentration screen (1021) includes a filtrate outlet (1024) corresponding to the filtrate channel (107), the filtrate outlet (1024) is connected to the concentration screen (1021), and the remaining second through holes (1022) are provided with a second sealing ring (4) around their periphery.
6. The tangential flow filtration membrane pack according to claim 5, characterized in that, The liquid inlet screen (1011), the concentration screen (1021), and the liquid exchange screen (1031) are all provided with sealing rings (6) on their periphery.
7. The tangential flow filtration membrane pack according to claim 6, characterized in that, The sealing ring (6) on the liquid exchange screen (1031) is integrally formed with the third sealing ring (5); And / or, the sealing ring (6) on the liquid inlet screen (1011) is integrally formed with the first sealing ring (3); And / or, the sealing ring (6) on the concentration screen (1021) is integrally formed with the second sealing ring (4).
8. The tangential flow filtration membrane pack according to any one of claims 2 to 7, characterized in that, The inlet channel (104), the outlet channel (105), the liquid exchange channel (106), and the filtrate channel (107) are located near the side of the membrane body (1). The inlet channel (104) and the outlet channel (105) are located on opposite sides of the membrane body (1) along a first direction (X), wherein the first direction (X) is the length direction of the membrane body (1).
9. The tangential flow filtration membrane pack according to claim 8, characterized in that, The fluid exchange channel (106) and the fluid inlet channel (104) are on the same side of the membrane body (1) along the first direction (X); Alternatively, the liquid exchange channel (106) and the liquid outlet channel (105) are arranged on the membrane body (1) along the first direction (X).
10. The tangential flow filtration membrane pack according to claim 9, characterized in that, The membrane body (1) is provided with a drain channel, which is only connected to the liquid exchange screen (1031). The membrane body (1) is provided with the liquid exchange channel (106) on only one side. The drain channel and the liquid exchange channel (106) are respectively provided on opposite sides of the membrane body (1) along the first direction.