Ultrafiltration device

Abstract

The utility model discloses a kind of ultrafiltration equipment, including control platform, filter before balance, ultrafiltration fixture and filter after balance, control platform is equipped with peristaltic pump and flow regulating valve, peristaltic pump is connected with first pipeline, and flow regulating valve is connected with second pipeline;Filter before balance is electrically connected with control platform, filter before balance supports filter before container, and filter before container is communicated with first pipeline and second pipeline respectively;Ultrafiltration fixture is communicated with first pipeline and second pipeline respectively, and ultrafiltration fixture is also communicated with third pipeline;First pipeline, second pipeline and third pipeline are all equipped with liquid pressure sensor, and liquid pressure sensor is electrically connected with control platform;Filter after balance is electrically connected with control platform, filter after balance supports filter after container, and filter after container is communicated with third pipeline.The utility model can realize modularization design, and it is convenient to independently configure and maintain function module.

Description

Technical Field

[0001] This utility model relates to the field of separation and purification equipment technology, and in particular to an ultrafiltration device. Background Technology

[0002] Ultrafiltration equipment is a widely used separation and purification device in the biopharmaceutical field. Existing ultrafiltration equipment is large in size and mostly adopts an integrated design, which is not conducive to the independent configuration and maintenance of each functional module. Utility Model Content

[0003] This invention aims to solve at least one of the technical problems existing in the prior art. To this end, this invention proposes an ultrafiltration device that can achieve a modular design, facilitating the independent configuration and maintenance of functional modules.

[0004] This utility model embodiment provides an ultrafiltration device, including:

[0005] The control platform is equipped with a peristaltic pump and a flow regulating valve. The peristaltic pump is connected to a first pipeline, and the flow regulating valve is connected to a second pipeline.

[0006] A pre-filter balance is electrically connected to the control platform. The pre-filter balance supports a pre-filter container, which is connected to the first pipeline and the second pipeline respectively.

[0007] An ultrafiltration fixture is connected to the first pipeline and the second pipeline respectively, and the ultrafiltration fixture is also connected to a third pipeline; liquid pressure sensors are installed in the first pipeline, the second pipeline and the third pipeline, and the liquid pressure sensors are electrically connected to the control platform;

[0008] The filtered balance is electrically connected to the control platform. The filtered container is supported by the filtered balance and is connected to the third pipeline.

[0009] According to some embodiments of the present invention, the pre-filter balance includes a base plate, a support plate, a weighing pressure sensor, and a sensor junction box. The weighing pressure sensor is installed between the base plate and the support plate, and is electrically connected to the sensor junction box and to the control platform through the sensor junction box.

[0010] According to some embodiments of this utility model, the pre-filtration balance and the post-filtration balance have the same structure.

[0011] According to some embodiments of the present invention, the ultrafiltration fixture is a membrane filter, and the membrane filter is provided with a first interface, a second interface and a third interface, and the first interface, the second interface and the third interface are all connected to the corresponding liquid pressure sensor.

[0012] According to some embodiments of the present invention, the membrane-encapsulated filter is equipped with an ultrafiltration membrane with a flat membrane encapsulation structure or an ultrafiltration membrane with a hollow fiber structure.

[0013] According to some embodiments of the present invention, the control platform includes a housing, a display and control unit, and a logic processor. The logic processor is electrically connected to the display and control unit, the peristaltic pump, and the flow regulating valve. The display and control unit, the peristaltic pump, and the flow regulating valve are all mounted on the housing.

[0014] According to some embodiments of the present invention, the flow regulating valve includes a flange fixing base, a liquid valve seat, a chuck chain assembly, and a drive motor. The flange fixing base is connected to the liquid valve seat and is fixed by the chuck chain assembly. The liquid valve seat is provided with a liquid channel connected to the second pipeline. An regulating valve core connected to the drive motor is installed inside the liquid valve seat. The regulating valve core is adapted to adjust the opening degree of the liquid channel.

[0015] According to some embodiments of the present invention, the flange fixing base is provided with a first connecting end and a second connecting end. The first connecting end is provided with a first contact surface and a first abutting slope located on the back of the first contact surface. The liquid valve seat is provided with a third connecting end. The third connecting end is provided with a second contact surface and a second abutting slope located on the back of the second contact surface. The second contact surface abuts against the first contact surface. The chuck chain assembly is engaged with the first abutting slope and the second abutting slope. The drive motor is installed on the second connecting end of the flange fixing base.

[0016] According to some embodiments of the present invention, the inner sidewall of the chuck chain assembly is provided with an annular groove, which is engaged with the first abutting inclined surface and the second abutting inclined surface.

[0017] According to some embodiments of the present invention, the distance between the first abutting inclined surface and the first contact surface gradually decreases from the inside to the outside along the radial direction of the flange fixing base.

[0018] The embodiments of this utility model have at least the following beneficial effects:

[0019] The control platform, pre-filter balance, ultrafiltration fixture, and post-filter balance adopt a modular design, allowing for independent configuration and maintenance. The pre-filter balance supports the pre-filter container, and the post-filter balance supports the post-filter container. The ultrafiltration fixture is connected to the pre-filter container via the first and second pipelines, and to the post-filter container via the third pipeline. The connection method is simple, clear, and easy to maintain. Liquid pressure sensors are installed in the first, second, and third pipelines to monitor the liquid pressure in the pipelines in real time. These sensors work in conjunction with a peristaltic pump and a flow regulating valve to control the liquid pressure in the pipelines, achieving both modular design and performance considerations.

[0020] Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. Attached Figure Description

[0021] The above and / or additional aspects and advantages of this utility model will become apparent and readily understood from the description of the embodiments taken in conjunction with the following drawings, in which:

[0022] Figure 1 This is a schematic diagram of the structure of the ultrafiltration device according to an embodiment of the present invention;

[0023] Figure 2 for Figure 1 A partial cross-sectional view of the pre-filtration balance of the ultrafiltration device is shown.

[0024] Figure 3 for Figure 1 A cross-sectional view of the flow control valve of an ultrafiltration device is shown.

[0025] Figure 4 for Figure 3 The center circle shows a magnified view of position A.

[0026] Figure label:

[0027] Control platform 100, housing 101, display and control unit 102, peristaltic pump 110, flow regulating valve 120, flange fixing base 121, first connecting end 1211, first contact surface 1212, first abutting slope 1213, second connecting end 1214, liquid valve seat 122, liquid channel 1221, regulating valve core 1222, third connecting end 1223, second contact surface 1224, second abutting slope 1225, chuck chain assembly 123, ring clamp 1231, locking element 1232, drive motor 124, pre-filter balance 200, base plate 201, support plate 202, weighing pressure sensor 203, sensor junction box 204, pre-filter container 210, ultrafiltration fixture 300, first pipeline 310, second pipeline 320, third pipeline 330, first liquid pressure sensor 340, second liquid pressure sensor 350, third liquid pressure sensor 360, post-filter balance 400, post-filter container 410. Detailed Implementation

[0028] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0029] In the description of this utility model, it should be understood that the directional descriptions, such as up, down, front, back, left, right, etc., indicate the directional or positional relationship based on the directional or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model.

[0030] In the description of this utility model, "several" means one or more, "multiple" means two or more, "greater than," "less than," and "exceeding" are understood to exclude the stated number, while "above," "below," and "within" are understood to include the stated number. If "first," "second," etc., are used in the description, they are only for distinguishing technical features and should not be construed as indicating or implying relative importance, or implicitly indicating the number of indicated technical features, or implicitly indicating the sequential relationship of the indicated technical features.

[0031] In the description of this utility model, unless otherwise explicitly defined, the terms "setting", "installation", "connection", etc. should be interpreted broadly, and those skilled in the art can reasonably determine the specific meaning of the above terms in this utility model in combination with the specific content of the technical solution.

[0032] Please refer to Figure 1This embodiment discloses an ultrafiltration device, including a control platform 100, a pre-filtration balance 200, an ultrafiltration fixture 300, and a post-filtration balance 400. The control platform 100 is equipped with a peristaltic pump 110 and a flow regulating valve 120. The peristaltic pump 110 is connected to a first pipeline 310, and the flow regulating valve 120 is connected to a second pipeline 320. The pre-filtration balance 200 is electrically connected to the control platform 100 and supports a pre-filtration container 210. The pre-filtration container 210 is connected to both the first pipeline 310 and the second pipeline 320. The first pipeline 310 is connected to the pre-filtration container... The outlet of the filter 210 is connected, and the second pipeline 320 is connected to the return outlet of the pre-filter container 210. The ultrafiltration clamp 300 is connected to the first pipeline 310 and the second pipeline 320 respectively, and the ultrafiltration clamp 300 is also connected to the third pipeline 330. Liquid pressure sensors are installed in the first pipeline 310, the second pipeline 320 and the third pipeline 330, and the liquid pressure sensors are electrically connected to the control platform 100. The post-filter balance 400 is electrically connected to the control platform 100, and the post-filter balance 400 supports the post-filter container 410, which is connected to the third pipeline 330.

[0033] The control platform 100, pre-filter balance 200, ultrafiltration fixture 300, and post-filter balance 400 adopt a modular design, supporting quick disassembly and independent maintenance of each component. Users can quickly replace or upgrade individual components according to actual needs, significantly reducing downtime for upgrades or malfunctions, simplifying the fault diagnosis process, and thus reducing maintenance costs. The pre-filter container 210 is connected to the ultrafiltration fixture 300 via the first pipe 310 and the second pipe 320, and the post-filter container 410 is connected to the ultrafiltration fixture 300 via the third pipe 330. The simple and clear connection structure reduces the complexity of assembly and disassembly, facilitates daily maintenance and cleaning, and the intuitive pipe layout effectively reduces the risk of misoperation, thus improving operational reliability. Liquid pressure sensors are installed in the first pipeline 310, the second pipeline 320, and the third pipeline 330 to continuously monitor the liquid pressure in the pipeline in real time. This allows for timely detection of abnormal pipeline pressure and, in conjunction with the peristaltic pump 110 and the flow regulating valve 120, dynamically adjusts the liquid pressure in the pipeline. This optimizes the uniformity and controllability of liquid flow and allows for more flexible control of differential pressure, transmembrane pressure, and flow rate, making the control of the ultrafiltration process more delicate and accurate.

[0034] Thus, the control platform 100, the pre-filter balance 200, the ultrafiltration clamp 300, and the post-filter balance 400 adopt a modular design, allowing for independent configuration and maintenance. The pre-filter balance 200 supports the pre-filter container 210, and the post-filter balance 400 supports the post-filter container 410. The ultrafiltration clamp 300 is connected to the pre-filter container 210 via the first pipe 310 and the second pipe 320, and to the post-filter container 410 via the third pipe 330. The connection method is simple, clear, and easy to maintain. Liquid pressure sensors are installed in the first pipe 310, the second pipe 320, and the third pipe 330, which can monitor the liquid pressure in the pipes in real time and work in conjunction with the peristaltic pump 110 and the flow regulating valve 120 to control the liquid pressure in the pipes. This modular design also takes into account the performance of the product.

[0035] Please refer to Figure 1 and Figure 2 The pre-filter balance 200 includes a base plate 201, a support plate 202, a weighing pressure sensor 203, and a sensor junction box 204. The weighing pressure sensor 203 is installed between the base plate 201 and the support plate 202, and is electrically connected to the sensor junction box 204, and also electrically connected to the control platform 100 through the sensor junction box 204. The base plate 201 serves as the foundation for assembly, thus supporting the weighing pressure sensor 203 and the sensor junction box 204. The support plate 202 supports the pre-filter container 210. The pre-filter balance 200 has a simple and integrated structure. The weighing pressure sensor 203 transmits signals through the sensor junction box 204, making the connection method simple and clear, and facilitating maintenance and replacement.

[0036] In some application examples, the pre-filter balance 200 and the post-filter balance 400 have the same structure. Using balances with the same structure can ensure the consistency of the results of pre-filter and post-filter testing, and can effectively reduce the learning cost of balance maintenance for maintenance personnel and improve the convenience of maintenance.

[0037] Please refer to Figure 1The ultrafiltration fixture 300 employs a membrane-encased filter, which is equipped with a first interface, a second interface, and a third interface, each connected to a corresponding liquid pressure sensor. A membrane-encased filter is a filter made of a membrane with a specific pore size, capable of sieving substances of different particle sizes through its membrane structure. The first, second, and third interfaces facilitate convenient connection to the first pipeline 310, the second pipeline 320, and the third pipeline 330, improving assembly and maintenance ease. Furthermore, the connection of the first, second, and third interfaces to corresponding liquid pressure sensors—for example, the first interface connecting to the first liquid pressure sensor 340, the second interface connecting to the second liquid pressure sensor 350, and the third interface connecting to the third liquid pressure sensor 360—allows for accurate monitoring of the liquid pressure at the inlet and outlet of the membrane-encased filter, and also enables simultaneous assembly or disassembly and maintenance of different liquid pressure sensors.

[0038] In some application examples, the membrane-encapsulated filter is equipped with a flat-sheet membrane envelope structure for ultrafiltration, while in other application examples, it is equipped with a hollow fiber structure for ultrafiltration. This allows for the selection of ultrafiltration membranes to meet the different product requirements, facilitating the search for a more suitable ultrafiltration membrane type for the ultrafiltration process.

[0039] Please refer to Figure 1 The control platform 100 includes a housing 101, a display and control unit 102, and a logic processor. The logic processor is electrically connected to the display and control unit 102, the peristaltic pump 110, and the flow regulating valve 120. The display and control unit 102, the peristaltic pump 110, and the flow regulating valve 120 are all mounted on the housing 101. For example, the display and control unit 102 uses an integrated touch screen, which simplifies the structure of the control platform 100 and improves the convenience of user operation. The logic processor uses an integrated device with logic processing capabilities, such as a microcontroller, to perform logic control on the display and control unit 102, the peristaltic pump 110, and the flow regulating valve 120, thereby realizing automated ultrafiltration process.

[0040] Please refer to Figure 3 and Figure 4The flow regulating valve 120 includes a flange fixing base 121, a liquid valve seat 122, a chuck chain assembly 123, and a drive motor 124. The flange fixing base 121 is connected to the liquid valve seat 122 and is secured by the chuck chain assembly 123. The liquid valve seat 122 has a liquid passage 1221 connected to the second pipeline 320. A regulating valve core 1222 connected to the drive motor 124 is installed inside the liquid valve seat 122. The regulating valve core 1222 is adapted to adjust the opening degree of the liquid passage 1221. The flange fixing base 121 and the liquid valve seat 122 are secured by the chuck chain assembly 123, which facilitates assembly, disassembly, and maintenance. The drive motor 124 can drive the regulating valve core 1222 inside the liquid valve seat 122 to move, thereby adjusting the opening degree of the liquid passage 1221 and thus regulating the liquid pressure of the second pipeline 320.

[0041] Please continue to refer to Figure 3 and Figure 4 The flange fixing base 121 is provided with a first connecting end 1211 and a second connecting end 1214. The first connecting end 1211 is provided with a first contact surface 1212 and a first abutting slope 1213 located on the back of the first contact surface 1212. The liquid valve seat 122 is provided with a third connecting end 1223. The third connecting end 1223 is provided with a second contact surface 1224 and a second abutting slope 1225 located on the back of the second contact surface 1224. The second contact surface 1224 abuts against the first contact surface 1212. The chuck chain assembly 123 is engaged with the first abutting slope 1213 and the second abutting slope 1225. The drive motor 124 is installed on the second connecting end 1214 of the flange fixing base 121. The first abutting inclined surface 1213 and the second abutting inclined surface 1225 can form a wedge-shaped locking structure. When the pressure between the first contact surface 1212 and the second contact surface 1224 increases, the pressure between the first contact surface 1212 and the second contact surface 1224 will be converted into radial compressive force of the first abutting inclined surface 1213 and the second abutting inclined surface 1225, so that the chuck chain assembly 123 can further lock the liquid valve seat 122 and the flange fixing base 121, thereby improving the reliability of the assembly.

[0042] Please refer to Figure 3 and Figure 4 The inner wall of the chuck chain assembly 123 is provided with an annular groove 1231, which is engaged with the first abutting inclined surface 1213 and the second abutting inclined surface 1225. By continuously applying pressure to the first abutting inclined surface 1213 and the second abutting inclined surface 1225, the liquid valve seat 122 and the flange fixing base 121 are reliably connected. The chuck chain assembly 123 is locked by the locking member 1232.

[0043] Figure 3The figure shows a cross-sectional view of the flange fixing base 121 and its radial direction. As can be seen from the figure, the first abutting slope 1213 and the first contact surface 1212 are two non-parallel surfaces. The distance between the first abutting slope 1213 and the first contact surface 1212 gradually decreases from the inside to the outside along the radial direction of the flange fixing base 121. When the first abutting slope 1213 of the flange fixing base 121 is subjected to a radially inward force, the first abutting slope 1213 can decompose the force into a first component force along the radial direction and a second component force along the axial direction. The second component force can cause the flange fixing base 121 to tend to move towards the liquid valve seat 122, making the first contact surface 1212 and the second contact surface 1224 more closely contacted. Similarly, the distance between the second abutting inclined surface 1225 and the second contact surface 1224 gradually decreases from the inside to the outside along the radial direction of the liquid valve seat 122. Under the snapping action of the chuck chain assembly 123, the connection between the liquid valve seat 122 and the flange fixing base 121 can be made tighter and more reliable.

[0044] The embodiments of the present utility model have been described in detail above with reference to the accompanying drawings. However, the present utility model is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present utility model.

Claims

1. An ultrafiltration device, characterized in that, include: The control platform (100) is equipped with a peristaltic pump (110) and a flow regulating valve (120). The peristaltic pump (110) is connected to a first pipeline (310), and the flow regulating valve (120) is connected to a second pipeline (320). A pre-filter balance (200) is electrically connected to the control platform (100). The pre-filter balance (200) supports a pre-filter container (210), which is connected to the first pipeline (310) and the second pipeline (320) respectively. An ultrafiltration fixture (300) is connected to the first pipeline (310) and the second pipeline (320) respectively, and the ultrafiltration fixture (300) is also connected to a third pipeline (330); the first pipeline (310), the second pipeline (320) and the third pipeline (330) are all equipped with liquid pressure sensors, and the liquid pressure sensors are electrically connected to the control platform (100); The filter balance (400) is electrically connected to the control platform (100), and the filter balance (400) supports the filter container (410), which is connected to the third pipeline (330).

2. The ultrafiltration device according to claim 1, characterized in that, The pre-filter balance (200) includes a base plate (201), a support plate (202), a weighing pressure sensor (203), and a sensor junction box (204). The weighing pressure sensor (203) is installed between the base plate (201) and the support plate (202). The weighing pressure sensor (203) is electrically connected to the sensor junction box (204) and is electrically connected to the control platform (100) through the sensor junction box (204).

3. The ultrafiltration device according to claim 1 or 2, characterized in that, The pre-filtration balance (200) and the post-filtration balance (400) have the same structure.

4. The ultrafiltration device according to claim 1, characterized in that, The ultrafiltration fixture (300) is a membrane filter, which is provided with a first interface, a second interface and a third interface, and the first interface, the second interface and the third interface are all connected to the corresponding liquid pressure sensor.

5. The ultrafiltration device according to claim 4, characterized in that, The membrane-encapsulated filter is equipped with an ultrafiltration membrane with a flat sheet membrane structure or an ultrafiltration membrane with a hollow fiber structure.

6. The ultrafiltration device according to claim 1, characterized in that, The control platform (100) includes a housing (101), a display and control unit (102), and a logic processor. The logic processor is electrically connected to the display and control unit (102), the peristaltic pump (110), and the flow regulating valve (120). The display and control unit (102), the peristaltic pump (110), and the flow regulating valve (120) are all mounted on the housing (101).

7. The ultrafiltration device according to claim 1, characterized in that, The flow regulating valve (120) includes a flange fixing base (121), a liquid valve seat (122), a chuck chain assembly (123), and a drive motor (124). The flange fixing base (121) is connected to the liquid valve seat (122) and is clamped and fixed by the chuck chain assembly (123). The liquid valve seat (122) is provided with a liquid channel (1221) connected to the second pipeline (320). An regulating valve core (1222) connected to the drive motor (124) is installed in the liquid valve seat (122). The regulating valve core (1222) is adapted to adjust the opening degree of the liquid channel (1221).

8. The ultrafiltration device according to claim 7, characterized in that, The flange fixing base (121) is provided with a first connecting end (1211) and a second connecting end (1214). The first connecting end (1211) is provided with a first contact surface (1212) and a first abutting slope (1213) located on the back of the first contact surface (1212). The liquid valve seat (122) is provided with a third connecting end (1223). The third connecting end (1223) is provided with a second contact surface (1224) and a second abutting slope (1225) located on the back of the second contact surface (1224). The second contact surface (1224) abuts against the first contact surface (1212). The chuck chain assembly (123) is engaged with the first abutting slope (1213) and the second abutting slope (1225). The drive motor (124) is installed on the second connecting end (1214) of the flange fixing base (121).

9. The ultrafiltration device according to claim 8, characterized in that, The inner wall of the chuck chain assembly (123) is provided with an annular groove (1231), which is engaged with the first abutting inclined surface (1213) and the second abutting inclined surface (1225).

10. The ultrafiltration device according to claim 8 or 9, characterized in that, The distance between the first abutting inclined surface (1213) and the first contact surface (1212) gradually decreases from the inside to the outside along the radial direction of the flange fixing base (121).

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