Membrane separator for biological component separation

Abstract

A membrane separator for biological component separation, comprising: a shell, the top, bottom and side of the shell are provided with biological liquid inlet, biological liquid outlet, water or dialysate outlet respectively; a center tube is arranged at the center inside the shell, and the lower end of the center tube extends to the outside through the bottom of the shell; the upper end of the center tube is closed and located below the biological liquid inlet, the lower end of the center tube is the water or dialysate inlet, and a plurality of drainage holes are arranged on the side of the center tube; a composite nuclear pore membrane ring is arranged inside the shell and surrounds the center tube, the central starting part is aligned with the drainage hole of the center tube, and the composite nuclear pore membrane ring is wound by a composite nuclear pore membrane bag. The membrane separator for biological component separation, adopts the composite nuclear pore membrane ring as the dialysis membrane, aims to solve the problems existing in the dialysis membrane of the existing biological component separator, and meets the demand for accurate separation of biological substances.

Description

Technical Field

[0001] This utility model relates to the field of medical device technology, specifically to a membrane separator for separating biological components. Background Technology

[0002] Membrane separators play a crucial role in the field of biological component separation, especially in clinical treatments such as hemodialysis.

[0003] Most existing membrane separators used for separating biological components employ hollow fiber dialysis membranes. These membranes typically have a three-layer structure, including an endothelial layer, a support layer, and an outer skin layer. However, this structure has significant drawbacks: its pores are tortuous, have poor pore size uniformity, exhibit large errors in pore size, and most pores are irregularly circular. These characteristics greatly limit the dialysis membrane's ability to precisely select for substances passing through it during blood filtration, thereby reducing dialysis efficiency and the precision of treatment.

[0004] Inadequate clearance of medium- and large molecular weight toxins, such as β2-microglobulin and α1-microglobulin, is a prominent issue during dialysis treatment. The continuous accumulation of these toxins in the body can lead to a series of long-term complications, severely impacting patients' quality of life and prognosis. While enlarging the membrane pores can help remove these toxins, it also introduces new problems. Larger pores allow larger proteins, such as globulins and albumins, to leak out, causing nutrient loss and further affecting the patient's condition. This creates a dilemma, making existing dialysis membranes insufficient to meet the actual needs of clinical treatment.

[0005] Nuclear pore membranes possess unique properties that offer new insights into the separation of biological components. They feature uniform pore size, controllable pore density, regular pore shape, and a smooth surface free from fiber shedding. These characteristics enable nuclear pore membranes to provide an optimal means for the precise separation of biological substances in medical and biological experiments. For example, in experiments requiring extremely high separation precision, nuclear pore membranes can accurately sieve biomolecules based on their size, ensuring the accuracy and reliability of experimental results. This demonstrates the enormous application potential of nuclear pore membranes in the field of biological component separation and their promise to solve the problems existing in current dialysis membranes.

[0006] Given the numerous problems with existing membrane separators for separating biological components, developing a novel membrane separator is of significant practical importance. Utility Model Content

[0007] Purpose of the utility model: In order to overcome the above shortcomings, the purpose of this utility model is to provide a membrane separator for the separation of biological components, which aims to solve the deficiencies in the structure and performance of existing dialysis membranes, improve the precise separation capability of biological substances, especially improve the removal efficiency of medium and large molecular toxins, while reducing the loss of nutrients such as proteins, meet the clinical treatment needs for efficient and precise hemodialysis, improve the quality of life of patients, and promote the development of the biomedical field.

[0008] Technical solution: A membrane separator for separating biological components, comprising:

[0009] The outer shell is provided with a biological liquid inlet, a biological liquid outlet, and a water or dialysis fluid outlet on its top, bottom, and sides, respectively.

[0010] The central tube is located at the center inside the outer shell, and its lower end extends through the bottom of the outer shell to the outside. The upper end of the central tube is closed and located below the biological liquid inlet. The lower end of the central tube is a water or dialysate inlet. Several drainage holes are provided on the side of the central tube.

[0011] A composite nuclear pore membrane ring is disposed inside the outer shell and surrounds the central tube, with its central starting portion aligned with the drain hole of the central tube; the composite nuclear pore membrane ring is composed of multiple layers of composite nuclear pore membrane bags wound together.

[0012] The membrane separator of this invention includes a shell, a central tube, and a composite nucleopore membrane ring. The shell provides physical protection and containment space for the entire device, preventing interference from external impurities. The central tube serves as a supply channel for water or dialysis fluid, ensuring that liquid can enter the interior of the membrane separator. The composite nucleopore membrane ring is the core component for achieving the separation of biological components, providing a crucial separation interface for the separation process.

[0013] The separation process is implemented as follows: the biological liquid enters through the biological liquid inlet at the top of the shell, undergoes component separation under the action of the composite nuclear pore membrane ring, and the separated biological liquid flows out through the biological liquid outlet at the bottom. Meanwhile, water or dialysate enters through the water or dialysate inlet at the lower end of the central tube, disperses through the drainage holes on the side of the central tube into the channels formed by the composite nuclear pore membrane ring, exchanges substances with the biological liquid, and then flows out through the water or dialysate outlet on the side of the shell. This design ensures the orderly conduct of the biological component separation process and improves separation efficiency.

[0014] Furthermore, in the aforementioned membrane separator for separating biological components, the outer shell includes: an upper cover, a body, and a lower cover. The upper cover is connected to the upper part of the body, and the lower part of the body is connected to the lower cover. A biological liquid inlet is provided at the top of the upper cover, a water or dialysate outlet is provided at the upper side of the body, and a biological liquid outlet is provided at the bottom of the lower cover. The central tube and the composite nuclear pore membrane ring are disposed inside the body, and the lower end of the central tube extends through the bottom of the lower cover to the outside.

[0015] The outer casing is divided into three parts: the upper cover, the main body, and the lower cover. This modular design makes the assembly and disassembly of the membrane separator more convenient. During the production process, each component can be manufactured separately and then assembled, improving production efficiency. During maintenance, if a component malfunctions, it can be replaced individually, reducing maintenance costs.

[0016] Furthermore, in the membrane separator for separating biological components described above, several of the drain holes are evenly distributed around the central tube, and the shape of the drain holes is circular or rectangular.

[0017] Several circular or rectangular drainage holes are formed on the side of the central tube. These holes uniformly distribute water or dialysate into the spiral channels of the membrane separator. Uniform liquid distribution helps ensure consistent separation conditions in all areas within the membrane separator, avoiding differences in separation performance caused by uneven liquid distribution, and improving the uniformity and stability of the separation. By rationally designing the shape and size of the drainage holes, the distribution of water or dialysate can be further optimized, allowing for better contact and material exchange with the biological fluid, thereby improving the separation efficiency and precision of biological components.

[0018] Furthermore, in the aforementioned membrane separator for separating biological components, the drain hole is rectangular in shape, and the edges of the drain hole are rounded.

[0019] Several narrow, rectangular drainage holes are formed on the side of the central tube (facing the starting part of the composite nucleopore membrane roll). The area of ​​the drainage hole, which is the width of the slit multiplied by the length of the hole, is equal to the cross-sectional area of ​​the central tube. This ensures that the flow rate and velocity of water flowing through the central tube and the drainage holes are the same. The flow rate of the drainage holes can be precisely adjusted by adjusting the flow rate of the central tube. The edges of the drainage holes are rounded to prevent burrs from affecting the liquid flow.

[0020] Furthermore, in the aforementioned membrane separator for separating biological components, the upper end of the central tube is at the same horizontal plane as the uppermost edge of the composite nuclear pore membrane ring.

[0021] The upper end of the central tube is at the same level as the uppermost edge of the composite nuclear pore membrane ring. This ensures that water or dialysate is evenly distributed to all layers of the membrane ring as it enters from the central tube. If the upper end of the central tube is too high or too low, it may lead to uneven distribution of water or dialysate among the membrane ring layers, resulting in short-circuiting. This means that some liquid flows rapidly through certain areas of the membrane separator without sufficient exchange of substances with the biological fluid, thus affecting the separation efficiency.

[0022] Furthermore, in the aforementioned membrane separator for separating biological components, the composite nuclear pore membrane bag has a membrane area specification of 0.3 m², 0.5 m², or 0.8 m².

[0023] The composite nuclear pore membrane bags are available in membrane area specifications of 0.3㎡, 0.5㎡, and 0.8㎡, and the number of composite nuclear pore membrane rings is determined based on the membrane area. Clinically, different specifications of products are matched for patients of different weights.

[0024] Furthermore, in the aforementioned membrane separator for separating biological components, the composite nuclear pore membrane bag is composed of two composite nuclear pore membranes.

[0025] The composite nuclear pore membrane bag is composed of two nuclear pore membranes. This composite structure combines the advantages of nuclear pore membranes, further enhancing the separation performance of the membrane separator. The synergistic effect of the two nuclear pore membranes improves the sieving accuracy of biological components, while also increasing the mechanical stability of the membrane and extending its service life. Furthermore, the design of the composite nuclear pore membrane bag allows the membrane separator to adapt to different biological component separation needs, expanding its application range. In various biomedical experiments or clinical treatments, appropriate nuclear pore membranes can be selected for composite separation based on specific requirements to achieve optimal separation results.

[0026] Furthermore, in the aforementioned membrane separator for separating biological components, the nuclear pore membrane includes a supporting base layer and a two-layer structure membrane sheet disposed on the supporting base layer, wherein the two-layer structure membrane sheet includes a loose layer and a dense layer from the inside out.

[0027] The nuclear pore membrane features a rationally designed structure. Its dense layer allows for precise sieving of biological materials, accurately separating them according to the size of biomolecules to ensure the accuracy and reliability of the separation results. The porous layer provides a buffer and channels for material passage, improving the efficiency of material passage through the membrane pores while reducing material accumulation on the membrane surface and lowering the risk of membrane fouling. This synergistic effect of the two-layer structure enables the nuclear pore membrane to function better in the separation of biological components, improving separation efficiency and precision.

[0028] Furthermore, in the aforementioned membrane separator for separating biological components, the thickness of the supporting substrate is 50-120 μm and the pore size is 1-20 μm, the thickness of the loose layer is 10-50 μm and the pore size is 0.1-10 μm, and the thickness of the dense layer is 100-200 nm and the pore size is 0-40 nm.

[0029] By limiting the thickness and pore size range of the support layer, loose layer, and dense layer, the above parameter settings are key to achieving efficient separation of biological components. The thickness and pore size of the support layer provide sufficient mechanical support for the membrane while allowing substances of a certain size to pass through; the thickness and pore size of the loose layer facilitate rapid passage and buffering of substances; and the thickness and pore size of the dense layer determine the sieving precision of biological substances. By rationally setting these parameters, the separation effect of the membrane separator can be optimized to meet different separation requirements.

[0030] Furthermore, in the aforementioned membrane separator for separating biological components, the composite nuclear pore membrane bag adopts a bi-directional symmetrical configuration, which is assembled by mirror-stacking two nuclear pore membranes with the supporting base layer as the symmetrical plane. The specific layer sequence configuration is: dense layer - loose layer - supporting base layer | supporting base layer - loose layer - dense layer; wherein, the dense layer serves as the functional layer facing the outer surface, and the supporting base layer forms the internal bonding interface.

[0031] This structural design ensures that both sides of the membrane have identical separation performance, improving membrane efficiency. Simultaneously, the supporting substrate forms an internal bonding interface, enhancing the membrane's mechanical stability and preventing deformation and damage during use. The dense layer, serving as the functional layer, faces outwards and can directly contact the biological fluid, enabling precise sieving of biological materials. This design guarantees the high efficiency and accuracy of the separation process, allowing biological components to be effectively separated under the action of the dense layer.

[0032] The composite nuclear pore membrane bag forms a continuous biological fluid flow channel in the axial direction, which is composed of dense interlayer gaps, and a spiral radial water or dialysate channel in the radial direction, which is composed of support interlayer gaps and a central tube. This dual-channel separation system enables the biological fluid and water or dialysate to flow in an orderly manner within the membrane separator, achieving efficient material exchange and separation.

[0033] The beneficial effects of this utility model are as follows:

[0034] (1) The membrane separator for biological component separation described in this utility model has problems such as tortuous pores and poor pore size uniformity in the prior art, which leads to limited dialysis efficiency and treatment precision. This utility model uses a composite nuclear pore membrane ring as a dialysis membrane. The nuclear pore membrane has the characteristics of uniform membrane pore size, controllable pore density and regular pore shape, which can improve the clearance efficiency of medium and large molecular toxins, while reducing the loss of nutrients such as protein, and meeting the clinical treatment needs for efficient and precise hemodialysis.

[0035] (2) The membrane separator for separating biological components described in this utility model optimizes the structure and parameters of the nuclear pore membrane, especially by designing the thickness of the dense layer to be 100-200 nm and the pore size to be 0-40 nm, thereby reducing the aspect ratio of the membrane pores and significantly improving the efficiency of liquids and macromolecules passing through the membrane pores, and further enhancing the precision of macromolecule sieving.

[0036] (3) The membrane separator for biological component separation described in this utility model is composed of multiple layers of composite nuclear pore membrane rings wound together. This winding design maximizes the separation interface in a limited space, increases the effective membrane area, and improves the separation efficiency. Compared with traditional hollow fiber dialysis synthetic membranes, the specific surface area is significantly improved. The structural design of the composite nuclear pore membrane ring avoids the risk of fiber lumen blockage, while enhancing the mechanical stability of the membrane and extending the service life of the membrane. Compared with traditional hollow fiber dialysis synthetic membranes, it has better reliability and durability.

[0037] (4) The membrane separator for biological component separation described in this utility model has openings at the upper and lower ends of the central liquid supply tube and side openings, especially the circular / rectangular drainage holes on the side, which can evenly disperse water or dialysate into the spiral channel of the membrane separator, avoiding uneven separation caused by excessive central flow velocity; the upper end of the central tube is at the same level as the uppermost edge of the composite nucleopore membrane ring, ensuring that water or dialysate can be evenly distributed to each layer of the membrane ring at the same time, avoiding short-circuiting and improving the consistency of separation effect;

[0038] (5) The membrane separator for separating biological components described in this utility model has broad application prospects in biomedical research, experimentation and clinical treatment. Attached Figure Description

[0039] Figure 1 This is an internal cross-sectional view of the membrane separator for separating biological components according to the present invention. Figure 1 ;

[0040] Figure 2 This is an internal cross-sectional view of the membrane separator for separating biological components according to the present invention. Figure 2 ;

[0041] Figure 3 This is an internal top sectional view of the membrane separator for separating biological components according to this utility model;

[0042] Figure 4 This is a partial cross-sectional view of the nuclear pore membrane of the membrane separator for separating biological components according to this utility model;

[0043] In the picture:

[0044] Outer shell 1, upper cover of outer shell 11, biological liquid inlet 111, outer shell body 12, water or dialysis fluid outlet 121, lower cover of outer shell 13, biological liquid outlet 131;

[0045] Central tube 2, water or dialysate inlet 201;

[0046] Composite nuclear pore membrane bag 3, nuclear pore membrane 31, supporting base layer 311, loose layer 312, dense layer 313;

[0047] Bonding point (1) A, Bonding point (2) B

[0048] C. Biological fluid flow channel; D. Water or dialysate channel. Detailed Implementation

[0049] The following is in conjunction with the appendix Figure 1 , 2 Examples 3, 4 and 1 further illustrate this utility model.

[0050] Example 1

[0051] like Figure 1 , 2 As shown, the membrane separator for separating biological components according to this utility model comprises a shell 1, a central tube 2, and a composite nuclear pore membrane roll, and its assembly is as follows:

[0052] 1. Outer shell assembly

[0053] (1) Component preparation: Prepare the outer shell top cover 11, outer shell body 12 and outer shell bottom cover 13, and ensure that the surface of each component is smooth, free of burrs, cracks and other defects, and that the dimensions meet the design requirements.

[0054] (2) Connection method: The upper cover 11 of the outer shell is connected to the upper part of the outer shell body 12 by a sealed connection method, and the lower part of the outer shell body 12 is connected to the lower cover 11 of the outer shell. For example, sealing rings or sealant can be used to seal the connection to prevent leakage of biological liquids, water, or dialysis fluid.

[0055] The outer shell 11 has a biological liquid inlet 111 at the top, the outer shell body 12 has a water or dialysis fluid outlet 121 at the upper side, and the outer shell 13 has a biological liquid outlet 131 at the bottom.

[0056] 2. Installation of central pipe 2

[0057] (1) Positioning and installation: Install the central tube 2 inside the center of the outer shell body 12. The upper end of the central tube 2 is closed and located below the biological liquid inlet 111. The lower end of the central tube 2 is the water or dialysis fluid inlet 201. Ensure that the lower end of the central tube 2 extends through the bottom of the lower cover 13 of the outer shell to the outside.

[0058] (2) Drainage holes: Several drainage holes are opened on the side of the central tube 2. The drainage holes are evenly distributed around the circumference of the central tube 2 and are circular or rectangular in shape. The drainage holes can be processed by laser drilling or mechanical drilling to ensure the dimensional accuracy and surface quality of the holes.

[0059] 3. Installation of composite nuclear pore membrane rings

[0060] (1) Preparation of composite nuclear pore membrane bag 3: The composite nuclear pore membrane bag 3 is composed of two nuclear pore membranes 31.

[0061] like Figure 3 As shown, the nuclear pore membrane 31 includes a supporting base layer 311 and a two-layer structure membrane disposed on the supporting base layer 31. The two-layer structure membrane includes a loose layer 312 and a dense layer 313 from the inside to the outside.

[0062] like Figure 2 , 3 As shown in Figure 4, the two nuclear pore membranes 31 are mirror-assembled with the supporting base layer 312 as the symmetrical plane. The specific layer sequence is: dense layer 313 - loose layer 312 - supporting base layer 311 | supporting base layer 311 - loose layer 312 - dense layer 313. Adhesive is used to seal the edges along the short sides of the two rectangular nuclear pore membranes 31 (the resulting adhesive joint (1)A) Figure 3 As shown, a composite nuclear pore membrane bag 3 with a certain thickness is constructed. This method ensures that the dense layer of the functional layer (dense layer 313) is exposed, while forming a stable bonding interface with the internal support base layer 312.

[0063] (2) Composite nuclear pore membrane ring winding: The prepared composite nuclear pore membrane bag 31 is wound into multiple layers to form a composite nuclear pore membrane ring. During the winding process, the winding tightness and winding layers should be controlled to ensure that the gap between each layer of the composite nuclear pore membrane ring is uniform. The number of winding layers is determined according to the design requirements of the membrane separator.

[0064] Furthermore, after winding and forming, the composite core-pore membrane ring needs to be sealed using selective end-face sealing technology to achieve the following:

[0065] 1. Local bonding is performed at both ends along the axial direction of the composite nucleopore membrane bag 31 (the bonded area formed is (2)B as shown) Figure 2 As shown), the bonding length is approximately 1-5% of the total axial length of the composite nucleopore membrane bag 31.

[0066] 2. Establish an adhesive sealing zone between the 312 supporting base layers.

[0067] 3. Maintaining the integrity and continuity of the 313 channels in the dense layer to construct a structure with:

[0068] ① Axially continuous biological fluid flow channel C (dense layer 313 gap);

[0069] ② A dual-pathway separation system for radially radiating water or dialysis fluid channels D (supporting base layer 312 gap).

[0070] Through the above-mentioned selective end-face sealing technology, a continuous biological fluid flow channel C composed of the gaps in the dense layer 313 is formed in the axial direction of the composite nuclear pore membrane bag 3, while a spiral radial water or dialysate channel D composed of the gaps in the supporting base layer 312 and the central tube 2 is formed in the radial direction.

[0071] (3) Installation and fixing: Install the composite nuclear pore membrane ring inside the outer shell 12, surrounding the central tube 2. During installation, ensure that the gap between the composite nuclear pore membrane ring and the central tube 2 is uniform to avoid local compression or excessive gap.

[0072] Furthermore, the upper end of the central tube 2 can be designed to be at the same horizontal level as the uppermost edge of the composite nuclear pore membrane ring. Simultaneously, the upper and lower ends of the central tube 2 are polished to make them smooth, preventing scratches on the composite nuclear pore membrane ring.

[0073] Example 2

[0074] Based on the structural foundation of Embodiment 1 above, the membrane separator for biological component separation described in this utility model has several narrow slit-shaped (rectangular) drainage holes on the side of the central tube 2 (facing the starting part of the center of the composite nucleopore membrane roll). The area of ​​the drainage hole, calculated as the width of the slit multiplied by the length of the hole, is equal to the cross-sectional area of ​​the central tube 2. This ensures that the flow rate and velocity of water flowing through the central tube 2 and the drainage holes are the same. The flow rate of the drainage holes can be precisely adjusted by regulating the flow rate of the central tube 2. The edges of the drainage holes are rounded to prevent burrs from affecting liquid flow.

[0075] Furthermore, the membrane area of ​​the composite nuclear pore membrane bag 3 is 0.3㎡, 0.5㎡, or 0.8㎡, and the number of composite nuclear pore membrane rings is determined based on the membrane area of ​​the composite nuclear pore membrane bag 3. Clinically, different specifications of products are matched to patients of different weights.

[0076] Furthermore, the thickness of the supporting base layer 311 is 50-120μm and the pore size is 1-20μm, the thickness of the loose layer 312 is 10-50μm and the pore size is 0.1-10μm, and the thickness of the dense layer 313 is 100-200nm and the pore size is 0-40nm.

[0077] Example 3

[0078] Based on the structural foundation of Embodiment 1 or Embodiment 2, the usage process of the membrane separator for separating biological components described in this utility model is as follows:

[0079] (a) Biological liquid separation process

[0080] 1. Biofluid inlet: Biofluid enters the membrane separator from the biofluid inlet 111 at the top of the outer shell cover 11.

[0081] 2. Water or dialysate inlet: Water or dialysate enters the central tube 2 from the water or dialysate inlet 201 at the lower end of the central tube 2.

[0082] 3. Component Separation: After water or dialysate enters the central tube 2, it is dispersed through the drain hole on the side of the central tube 2 into the spiral channel formed by the composite nuclear pore membrane ring in the membrane separator. Water or dialysate flows in the spiral channel, exchanging substances with the biological fluid inside the membrane separator, carrying away medium and large molecular toxins and other harmful substances from the biological fluid. Specifically, biological components are separated through the synergistic effect of the two-layer structure of the nuclear pore membrane 31. The dense layer 313 precisely sieves the biological material, while the loose layer 312 provides a buffer and channel for the passage of substances. The biological fluid flows in the continuous biological fluid flow channel C formed axially by the gaps in the dense layer 313 within the composite nuclear pore membrane ring, exchanging substances with water or dialysate. The water or dialysate carries away medium and large molecular toxins and other harmful substances from the biological fluid. It then flows radially in the spiral-shaped water or dialysate channel D formed by the gaps in the supporting layer 312 and the central tube 2.

[0083] 3. Liquid outflow: The separated biological liquid flows out of the membrane separator from the biological liquid outlet 131 at the bottom of the outer shell 13. The water or dialysate after mass exchange with the biological liquid flows out of the membrane separator from the water or dialysate outlet 121 on the side of the outer shell 12.

[0084] (II) Maintenance and Care of Membrane Separators

[0085] 1. Regular cleaning

[0086] Cleaning cycle: The cleaning cycle is determined based on the frequency of use of the membrane separator and the nature of the biological liquid being treated.

[0087] Cleaning method: Use a suitable cleaning agent to clean the membrane separator. The choice of cleaning agent should consider its compatibility with the membrane material and its cleaning effect. During cleaning, inject the cleaning agent into the membrane separator through the biological liquid inlet, water, or dialysate inlet. After soaking for a certain period of time, rinse thoroughly with clean water.

[0088] 2. Membrane replacement

[0089] Replacement conditions: When the separation efficiency of the membrane separator decreases significantly, for example, when the removal rate of medium and large molecular toxins is lower than the specified standard, or when the membrane is damaged or blocked, the composite nucleopore membrane ring needs to be replaced.

[0090] Replacement method: Open the outer casing, remove the old composite nuclear pore membrane ring, and then install the new composite nuclear pore membrane ring. During the replacement process, care must be taken to avoid damaging the membrane ring, and the new membrane ring must be installed in the correct position.

[0091] Performance testing: After replacing the membrane ring, the membrane separator is subjected to performance testing to ensure that its separation performance has returned to normal.

[0092] 2. Equipment Inspection

[0093] Inspection content: Regularly inspect the outer shell 1, central tube 2, composite nucleopore membrane ring and other components of the membrane separator to check for looseness, leakage, wear and other conditions.

[0094] In summary, the membrane separator for separating biological components described in this invention can overcome the shortcomings of existing dialysis membranes in terms of structure and performance, improve the precise separation capability of biological substances, especially the removal efficiency of medium and large molecular toxins, while reducing the loss of nutrients such as proteins. It can meet the clinical treatment needs for efficient and precise hemodialysis and promote the development of the biomedical field.

[0095] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements can be made without departing from the principle of the present utility model, and these improvements should also be considered within the protection scope of the present utility model.

Claims

1. A membrane separator for separating biological components, characterized in that, include: The outer shell (1) is provided with a biological liquid inlet (111), a biological liquid outlet (131), and a water or dialysis fluid outlet (121) on its top, bottom and side. The central tube (2) is located at the center inside the outer shell (1), and the lower end of the central tube (2) extends through the bottom of the outer shell (1) to the outside; the upper end of the central tube (2) is closed and located below the biological liquid inlet (111), and the lower end of the central tube (2) is a water or dialysis fluid inlet (201). Several drainage holes are provided on the side of the central tube (2). The composite nuclear pore membrane ring is disposed inside the outer shell (1) and surrounds the central tube (2), with its central starting part aligned with the drain hole of the central tube (2); the composite nuclear pore membrane ring is composed of multiple layers of composite nuclear pore membrane bag (3) wound together.

2. The membrane separator for separating biological components according to claim 1, characterized in that, The outer shell (1) includes: an upper cover (11), a body (12), and a lower cover (13). The upper cover (11) is connected to the upper part of the body (12), and the lower part of the body (12) is connected to the lower cover (13). The upper cover (11) is provided with a biological liquid inlet (111) at the top, the upper part of the side of the body (12) is provided with a water or dialysis fluid outlet (121), and the lower cover (13) is provided with a biological liquid outlet (131) at the bottom. The central tube (2) and the composite nuclear pore membrane ring are disposed inside the body (12), and the lower end of the central tube (2) extends through the bottom of the lower cover (13) to the outside.

3. The membrane separator for separating biological components according to claim 1, characterized in that, Several drainage holes are evenly distributed around the central tube (2), and the shape of the drainage holes is circular or rectangular.

4. The membrane separator for separating biological components according to claim 3, characterized in that, The drain hole is rectangular in shape; the edges of the drain hole are rounded.

5. The membrane separator for separating biological components according to claim 1, characterized in that, The upper end of the central tube (2) is at the same level as the uppermost edge of the composite nuclear pore membrane ring.

6. The membrane separator for separating biological components according to claim 1, characterized in that, The membrane area of ​​the composite nuclear pore membrane bag (3) is 0.3㎡, 0.5㎡, or 0.8㎡.

7. The membrane separator for separating biological components according to claim 1, characterized in that, The composite nuclear pore membrane bag (3) is composed of two nuclear pore membranes (31).

8. The membrane separator for separating biological components according to claim 7, characterized in that, The nuclear pore membrane (31) includes a supporting base layer (311) and a two-layer structure membrane disposed on the supporting base layer (311). The two-layer structure membrane includes a loose layer (312) and a dense layer (313) from the inside to the outside.

9. The membrane separator for separating biological components according to claim 8, characterized in that, The thickness of the supporting base layer (311) is 50-120μm and the pore size is 1-20μm, the thickness of the loose layer (312) is 10-50μm and the pore size is 0.1-10μm, and the thickness of the dense layer (313) is 100-200nm and the pore size is 0-40nm.

10. The membrane separator for separating biological components according to claim 8, characterized in that, The composite nuclear pore membrane bag (3) adopts a double-sided symmetrical configuration, which is composed of two nuclear pore membranes (31) assembled by mirror stacking with the supporting base layer (311) as the symmetrical plane. The specific layer sequence configuration is: dense layer (313) - loose layer (312) - supporting base layer (311) | supporting base layer (311) - loose layer (312) - dense layer (313); wherein, the dense layer (313) serves as the functional layer facing the outer surface, and the supporting base layer (311) forms the internal bonding interface.

Images