A device for purifying a pharmaceutical intermediate

Abstract

The utility model relates to technical field of medical equipment, and disclose a kind of purification device of pharmaceutical intermediates, including purification box, the inside wall of purification box is equipped with limit block, the inside of purification box is equipped with storage mechanism, the storage mechanism includes storage box, the back of storage box is equipped with moving block, filter bag is placed in the inside of storage box, one side of the storage mechanism is equipped with transmission mechanism, the inside of purification box is equipped with agitating mechanism, the agitating mechanism includes agitating plate, the both ends of agitating plate are fixedly connected with mounting block, the bottom of mounting block is fixedly connected with connecting rod, by making the reciprocating motion of storage box, prompting the intermediates in filter bag and solvent are in full contact, accelerate dissolution and impurity separation, and impurity is directly taken out and handled by being left in filter bag inside, so it can not need to clean the entire purification box inner wall, it is very convenient.

Description

Technical Field

[0001] This utility model relates to the field of pharmaceutical equipment technology, specifically a purification device for pharmaceutical intermediates. Background Technology

[0002] Pharmaceutical intermediates are chemical raw materials or products used in drug synthesis processes. These chemical products do not require a drug production license and can be produced in ordinary chemical plants. As long as they meet certain quality standards, they can be used in drug synthesis. Pharmaceutical intermediates are key raw materials in drug synthesis processes, and their purity directly affects the quality and efficacy of the final drug. Purification devices can remove impurities from pharmaceutical intermediates and improve their purity. In use, a certain amount of solid pharmaceutical intermediate is first weighed and transferred to a dissolving container in the purification device. Based on the properties of the intermediate, a suitable solvent is selected for dissolution. After dissolution, the solution is filtered, and finally sent to a concentration device to prepare intermediate powder. However, during the dissolution and filtration process, the intermediate cannot be completely dissolved in the solvent, resulting in material waste. Furthermore, impurities generated during the intermediate production process adhere to the inner wall of the dissolving container, making them difficult to clean. Utility Model Content

[0003] (a) Technical problems to be solved

[0004] To address the shortcomings of existing technologies, this invention provides a purification device for pharmaceutical intermediates, which solves the problems of incomplete dissolution and residual impurities in the intermediates.

[0005] (II) Technical Solution

[0006] To achieve the above objectives, this utility model provides the following technical solution: a purification device for pharmaceutical intermediates, comprising a purification chamber, a limiting block installed on the inner wall of the purification chamber, a storage mechanism inside the purification chamber, the storage mechanism comprising a storage box, a movable block on the back of the storage box, a filter bag placed inside the storage box, a transmission mechanism installed on one side of the storage mechanism, and a stirring mechanism inside the purification chamber, the stirring mechanism comprising a stirring plate, mounting blocks fixedly connected to both ends of the stirring plate, and a connecting rod fixedly connected to the bottom of the mounting blocks, thereby increasing the reaction rate by rotating the stirring plate.

[0007] In some embodiments, a transmission mechanism is provided on one side of the purification chamber. The transmission mechanism includes a first transmission wheel, one end of which is fixedly connected to a motor, and the end of the first transmission wheel away from the motor is fixedly connected to a lead screw. A transmission belt is slidably connected to the surface of the first transmission wheel, and one end of the transmission belt is slidably connected to a second transmission wheel.

[0008] In some embodiments, the surface of the storage box is provided with a strip groove.

[0009] In some embodiments, the surface of the agitator plate is provided with a plurality of through holes.

[0010] In some embodiments, the purification chamber has a discharge port on one side, and the discharge port is equipped with a valve.

[0011] In some embodiments, an air pump is installed on the front of the purification chamber, one end of the air pump is fixedly connected to a connecting pipe, one end of the connecting pipe is welded to an exhaust pipe, and the surface of the exhaust pipe is provided with air holes.

[0012] In some embodiments, a movable block is threadedly connected to the outer surface of the lead screw, and a limiting groove is formed on the back of the movable block, the limiting groove being slidably connected to the limiting block.

[0013] In some embodiments, the surface of the filter bag is coated with an ultrafiltration membrane made of polyethersulfone and polytetrafluoroethylene.

[0014] (III) Beneficial Effects

[0015] Compared with the prior art, the present invention provides a purification device for pharmaceutical intermediates, which has the following beneficial effects:

[0016] 1. This utility model involves placing the pharmaceutical intermediate to be purified into a filter bag in a storage mechanism. The polyethersulfone ultrafiltration membrane wrapped on the surface of the filter bag can initially intercept large molecular impurities. Then, solvent and reaction solution are injected into the purification chamber. After that, the motor in the transmission mechanism is started to drive the first transmission wheel to rotate. At this time, the second transmission wheel and the lead screw are driven to rotate through the transmission belt. The lead screw and the moving block are threaded together, causing the storage chamber to move back and forth along the limiting block. This promotes full contact between the intermediate and the solvent in the filter bag, accelerates dissolution and separation of impurities, and the impurities are left inside the filter bag and can be directly removed for processing. In this way, it is not necessary to clean the entire inner wall of the purification chamber.

[0017] 2. This invention utilizes the rotation of the stirring plate to create vortices in the through holes, enhancing the mixing effect between the solution and intermediates and increasing the purification reaction rate. Simultaneously, the airflow transmitted through the bottom vents generates small vortices and irregular flows, thereby allowing the solvent and drug intermediates to react more thoroughly. Attached Figure Description

[0018] Figure 1 This is a schematic diagram of the overall structure of this utility model;

[0019] Figure 2 This is a schematic diagram of the cross-sectional structure of the purification box of this utility model;

[0020] Figure 3 This is a schematic diagram of the transmission mechanism structure of this utility model;

[0021] Figure 4 This is a schematic diagram of the storage mechanism structure of this utility model;

[0022] Figure 5 This is a schematic diagram of the stirring mechanism of this utility model;

[0023] In the diagram: 1. Purification box; 101. Outlet; 102. Limiting block; 2. Air pump; 201. Connecting pipe; 202. Exhaust pipe; 203. Air hole; 3. Transmission mechanism; 301. Motor; 302. First transmission wheel; 303. Transmission belt; 304. Second transmission wheel; 305. Lead screw; 4. Storage mechanism; 401. Storage box; 402. Moving block; 403. Limiting groove; 404. Filter bag; 5. Stirring mechanism; 501. Connecting rod; 502. Mounting block; 503. Stirring plate; 504. Through hole. Detailed Implementation

[0024] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of this application, and not all of the embodiments. Based on the embodiments of this application, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of this application.

[0025] It should be noted that all directional indications in the embodiments of this application are only used to explain the relative positional relationship and movement of each component in a specific posture. If the specific posture changes, the directional indications will also change accordingly.

[0026] In this application, unless otherwise expressly specified and limited, the terms "connection," "fixed," etc., should be interpreted broadly. For example, "fixed" can mean a fixed connection, a detachable connection, or an integral part; it can mean a mechanical connection or an electrical connection; it can mean a direct connection or an indirect connection through an intermediate medium; it can mean the internal communication of two components or the interaction between two components, unless otherwise expressly limited. Those skilled in the art can understand the specific meaning of the above terms in this application according to the specific circumstances.

[0027] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, the technical solutions of the various embodiments can be combined with each other, but only on the basis of being achievable by those skilled in the art. If the combination of technical solutions is contradictory or impossible to implement, such a combination of technical solutions should be considered non-existent and not within the scope of protection claimed in this application.

[0028] Reference Figures 1-5 This utility model provides a purification device for pharmaceutical intermediates, including a purification chamber 1. A limiting block 102 is installed on the inner wall of the purification chamber 1. The purification chamber 1 is provided with a storage mechanism 4, which includes a storage box 401. A moving block 402 is provided on the back of the storage box 401. A filter bag 404 is placed inside the storage box 401. A transmission mechanism 3 is installed on one side of the storage mechanism 4. The purification chamber 1 is provided with a stirring mechanism 5, which includes a stirring plate 503. Mounting blocks 502 are fixedly connected to both ends of the stirring plate 503. A connecting rod 501 is fixedly connected to the bottom of the mounting block 502. The reaction rate is increased by rotating the stirring plate 503.

[0029] In a preferred embodiment, a transmission mechanism 3 is provided on one side of the purification box 1. The transmission mechanism 3 includes a first transmission wheel 302, one end of which is fixedly connected to a motor 301, and the other end of the first transmission wheel 302 away from the motor 301 is fixedly connected to a lead screw 305. A transmission belt 303 is slidably connected to the surface of the first transmission wheel 302, and one end of the transmission belt 303 is slidably connected to a second transmission wheel 304.

[0030] In a preferred embodiment, the surface of the storage box 401 is provided with a strip groove to provide a channel for the solution to flow through, so that the solution can fully contact the intermediate.

[0031] In a preferred embodiment, the surface of the stirring plate 503 is provided with a plurality of through holes 504.

[0032] Through-hole 504 can enhance the flow and mixing efficiency of liquids.

[0033] In a preferred embodiment, the purification chamber 1 has an outlet 101 on one side, and the outlet 101 is equipped with a valve.

[0034] In a preferred embodiment, an air pump 2 is installed on the front of the purification box 1. One end of the air pump 2 is fixedly connected to a connecting pipe 201, and an exhaust pipe 202 is welded to one end of the connecting pipe 201. The surface of the exhaust pipe 202 is provided with air holes 203.

[0035] In a preferred embodiment, a movable block 402 is threadedly connected to the outer surface of the lead screw 305, and a limiting groove 403 is formed on the back of the movable block 402, which is slidably connected to the limiting block 102.

[0036] In a preferred embodiment, the surface of the filter bag 404 is coated with an ultrafiltration membrane made of polyethersulfone and polytetrafluoroethylene.

[0037] Ultrafiltration membranes can efficiently retain micro-impurities and microorganisms while maintaining high permeability.

[0038] The working principle of this invention is as follows: The pharmaceutical intermediate to be purified is placed into the filter bag 404 of the storage mechanism 4. The polyethersulfone ultrafiltration membrane wrapped on the surface of the filter bag 404 can initially intercept large molecular impurities. Then, solvent and reaction solution are injected into the purification chamber 1. After that, the motor 301 in the transmission mechanism 3 is started to drive the first transmission wheel 302 to rotate. At this time, the second transmission wheel 304 and the lead screw 305 are driven to rotate through the transmission belt 303. The lead screw 305 is threadedly engaged with the moving block 402, causing the storage chamber 401 to reciprocate left and right along the limiting block 102, so as to promote full contact between the intermediate in the filter bag 404 and the solvent, and accelerate the purification process. The process involves dissolving and separating impurities, with the impurities remaining inside the filter bag 404 and being directly removed for processing. This eliminates the need to clean the entire inner wall of the purification chamber 1. The stirring mechanism 5 is connected to the second transmission wheel 304 via a connecting rod 501. Therefore, when the motor 301 starts, the connecting rod 501 begins to rotate, driving the stirring plate 503 to rotate. The through holes 504 on the surface of the stirring plate 503 reduce fluid resistance and simultaneously create vortices to enhance the mixing effect and increase the purification reaction rate. In conjunction with the airflow transmitted through the bottom vent 203, small vortices and irregular flows are generated, allowing the solvent and drug intermediates to react more thoroughly.

[0039] In the description of this specification, the references to terms such as "one embodiment," "some embodiments," "example," "specific example," and "some examples" indicate that a specific feature, structure, material, or characteristic described in connection with that embodiment or example is included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples. In addition, those skilled in the art can combine and integrate the different embodiments or examples described in this specification.

[0040] Furthermore, the technical solutions of the various embodiments can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the scope of protection claimed in this application.

[0041] Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the present invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A purification apparatus for pharmaceutical intermediates, characterized in that: The purification chamber (1) includes a purification box (1), a limiting block (102) installed on the inner side wall of the purification box (1), a storage mechanism (4) is provided inside the purification box (1), the storage mechanism (4) includes a storage box (401), a moving block (402) is provided on the back of the storage box (401), a filter bag (404) is placed inside the storage box (401), a transmission mechanism (3) is installed on one side of the storage mechanism (4), a stirring mechanism (5) is provided inside the purification box (1), the stirring mechanism (5) includes a stirring plate (503), the two ends of the stirring plate (503) are fixedly connected to the mounting blocks (502), and the bottom of the mounting blocks (502) is fixedly connected to the connecting rod (501). The reaction rate is increased by rotating the stirring plate (503).

2. The purification apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The purification box (1) is provided with a transmission mechanism (3) on one side. The transmission mechanism (3) includes a first transmission wheel (302). One end of the first transmission wheel (302) is fixedly connected to a motor (301). The end of the first transmission wheel (302) away from the motor (301) is fixedly connected to a lead screw (305). A transmission belt (303) is slidably connected to the surface of the first transmission wheel (302). One end of the transmission belt (303) is slidably connected to a second transmission wheel (304).

3. The purification apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The surface of the storage box (401) is provided with a strip groove.

4. The purification apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The surface of the stirring plate (503) is provided with multiple through holes (504).

5. The purification apparatus for pharmaceutical intermediates according to claim 1, characterized in that: The purification chamber (1) is provided with an outlet (101) on one side, and a valve is provided on the outlet (101).

6. The purification apparatus for pharmaceutical intermediates according to claim 1, characterized in that: An air pump (2) is installed on the front of the purification box (1). One end of the air pump (2) is fixedly connected to a connecting pipe (201). An exhaust pipe (202) is welded to one end of the connecting pipe (201). An air hole (203) is opened on the surface of the exhaust pipe (202).

7. The purification apparatus for pharmaceutical intermediates according to claim 2, characterized in that: The outer surface of the lead screw (305) is threaded with a moving block (402), and a limiting groove (403) is provided on the back of the moving block (402), and the limiting groove (403) is slidably connected to the limiting block (102).

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