A tunable amplitude polypeptide synthesis reactor
By designing an adjustable amplitude peptide synthesis reactor, and using a counterweight block with a combination of a strong spring and a rack to adjust the amplitude, combined with a temperature control component, the problem of uneven reaction during peptide synthesis was solved, thus improving synthesis efficiency and quality.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- PEPTIORIGIN BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-06-25
- Publication Date
- 2026-07-14
AI Technical Summary
Existing peptide synthesis reactors are inadequate in terms of amplitude regulation and reaction uniformity, and cannot be precisely adjusted according to the characteristics of different raw materials, resulting in uneven reactions and affecting synthesis efficiency and quality.
An adjustable amplitude peptide synthesis reactor was designed. The position of the counterweight is adjusted by the cooperation of a strong spring, pusher and rack. The motor drives the counterweight to rotate to generate different amplitudes. Combined with the temperature control component, the reaction temperature is precisely controlled to ensure uniform mixing of peptide raw materials.
It achieves uniform mixing of peptide raw materials, improves synthesis efficiency and quality, enhances the coordination between temperature control and vibration frequency, and adapts to different reaction requirements.
Smart Images
Figure CN224486056U_ABST
Abstract
Description
Technical Field
[0001] This invention relates to the field of peptide processing technology, specifically to an adjustable amplitude peptide synthesis reactor. Background Technology
[0002] In the biopharmaceutical field, peptide synthesis is a crucial step, widely used in drug development, disease treatment, and biodiagnostics. Peptide synthesis typically requires specific reaction conditions, and the reaction temperature, reaction time, and reaction uniformity directly impact the synthesis results. Reactor design and optimization are paramount in peptide synthesis, particularly in temperature control, mixing, and vibration, which can effectively improve synthesis efficiency and product quality. However, most current peptide synthesis reactors suffer from shortcomings in amplitude regulation, reaction uniformity, and reaction time control. Precise amplitude control to adapt to the requirements of different raw materials presents significant technical challenges.
[0003] Most existing peptide synthesis reactors employ fixed amplitude or simple mechanical vibration, making it difficult to precisely adjust the amplitude according to different raw material characteristics during synthesis. Traditional equipment often cannot flexibly adjust the vibration intensity according to reaction requirements, leading to uneven mixing of reactants, low synthesis efficiency, and potentially affecting peptide quality in some high-precision and complex synthesis processes. Furthermore, the temperature control and amplitude adjustment systems in existing equipment typically operate independently, lacking an effective linkage mechanism. This results in poor coordination between temperature control and vibration frequency, thus impacting the overall peptide synthesis outcome. Utility Model Content
[0004] The purpose of this invention is to provide an adjustable amplitude peptide synthesis reactor to solve the problem in the background art where uneven reaction of peptide raw materials inside the reactor is easily caused by inconsistent amplitude.
[0005] To achieve the above objectives, the present invention provides the following technical solution: an adjustable amplitude peptide synthesis reactor, comprising a cylindrical body, wherein a reaction assembly is provided inside the cylindrical body, a temperature control assembly is provided inside the cylindrical body, the heating end of the temperature control assembly is installed outside the container of the reaction assembly, and an amplitude generating assembly is provided inside the cylindrical body.
[0006] Furthermore, the reaction assembly includes a reaction cylinder installed on the top wall of the inner cylinder, the output end of the reaction cylinder is fixedly connected to a discharge pipe, the bottom end of the discharge pipe penetrates the cylinder and extends to the bottom of the cylinder, the bottom end of the discharge pipe is fixedly connected to a solenoid valve, and a guide ring is fixedly installed on the inner bottom wall of the cylinder.
[0007] Furthermore, the amplitude generating component includes a motor mounted on the bottom surface of the reaction cylinder. A rotating rod is fixedly mounted on the output end of the motor. A connecting block is fixedly mounted on the bottom end of the rotating rod. A counterweight is provided on the right side of the connecting block. A sliding groove is opened on the left side of the counterweight. A connecting plate is slidably mounted on the inner wall of the sliding groove. The left end of the connecting plate is fixedly mounted to the right side of the connecting block. A set of toothed grooves is opened on the bottom surface of the connecting plate. A square tube is fixedly connected to the bottom surface of the counterweight. Two strong springs are fixedly mounted on the inner bottom wall of the square tube. A push block is fixedly mounted on the bottom end of the two strong springs. A set of racks is fixedly mounted on the top end of the push block. The set of racks is adapted to the top end of the set of toothed grooves.
[0008] Furthermore, the temperature control component includes a heating ring installed on the outer surface of the reaction cylinder, and a temperature sensor is fixedly installed on the inner wall of the reaction cylinder.
[0009] Furthermore, a sealing ring is fixedly installed on the bottom surface of the reaction cylinder, and the outer surface of the sealing ring is fixedly installed to the inner wall of the cylinder.
[0010] Furthermore, a set of support columns are fixedly installed on the inner bottom wall of the cylinder, and the top of each support column is fixedly installed to the bottom surface of the reaction cylinder.
[0011] Furthermore, a set of support legs is fixedly installed on the bottom surface of the cylinder, a control panel is fixedly installed on the upper surface of the cylinder, two feed pipes are fixedly connected to the upper surface of the cylinder, a sealing cap is threaded onto the outer surface of each feed pipe, and an opening is provided on the bottom surface of the cylinder.
[0012] Furthermore, a guide groove is provided on the right side of the square tube, and a guide block is slidably installed on the inner wall of the guide groove. The left end of the guide block is fixedly installed with the right end of the push block. A through groove is provided on the upper surface of the slide groove, and a limit groove is slidably installed on the inner wall of the through groove. The bottom surface of the limit groove is fixedly installed with the upper surface of the connecting plate.
[0013] Compared with the prior art, the beneficial effects of this utility model are: by providing a strong spring, a push plate and a rack, the strong spring can push the push plate and rack to move upward. By utilizing the cooperation of the rack and tooth groove, the counterweight can be adjusted according to the position of the counterweight. With the cooperation of the motor, rotating rod and connecting block, the motor drives the counterweight to rotate and generate different amplitudes, so that the amplitude can be suitable for different raw materials, ensuring that the peptide raw materials are more uniform. Attached Figure Description
[0014] Figure 1 This is a schematic diagram of the overall structure of this utility model;
[0015] Figure 2This is a three-dimensional structural schematic diagram of the orthographic section of this utility model;
[0016] Figure 3 This is a three-dimensional structural schematic diagram of the present invention, shown in a top sectional view.
[0017] Figure 4 This is a three-dimensional structural schematic diagram of the amplitude generating component of this utility model, shown in a cross-sectional view.
[0018] Figure 5 This utility model Figure 4 Enlarged schematic diagram of the structure at point A in the middle.
[0019] The attached diagram lists the components represented by each number as follows:
[0020] 1. Cylinder; 101. Control Panel; 102. Feed Pipe; 103. Sealing Cover; 104. Support Leg; 105. Port; 2. Reaction Components; 201. Reaction Cylinder; 202. Discharge Pipe; 203. Solenoid Valve; 204. Guide Ring; 3. Temperature Control Components; 301. Heating Ring; 302. Temperature Sensor; 4. Amplitude Generating Components; 401. Motor; 402. Rotating Rod; 403. Connecting Block; 404. Counterweight; 405. Square Tube; 406. Strong Spring; 407. Guide Groove; 408. Connecting Plate; 409. Gear Groove; 410. Push Block; 411. Rack; 412. Slide Groove; 413. Guide Block; 414. Through Groove; 415. Limit Groove; 5. Support Column; 6. Sealing Ring.
[0021] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation
[0022] It should be understood that the specific embodiments described herein are merely illustrative of the present invention and are not intended to limit the present invention.
[0023] In the description of this utility model, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the accompanying drawings and are only for the convenience of describing this utility model and simplifying the description. They do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of indicated technical features. Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of the stated features. In the description of this utility model, "a plurality of" means two or more, unless otherwise explicitly and specifically defined.
[0024] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection, a direct connection, or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.
[0025] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.
[0026] Please refer to Figures 1 to 5 This utility model provides a technical solution: an adjustable amplitude peptide synthesis reactor, including a cylinder 1, a reaction component 2 inside the cylinder 1, a temperature control component 3 inside the cylinder 1, the heating end of the temperature control component 3 being installed outside the container of the reaction component 2, and an amplitude generating component 4 inside the cylinder 1.
[0027] In one embodiment, please refer to Figure 2The reaction assembly 2 includes a reaction cylinder 201 installed on the inner top wall of the cylinder 1. The output end of the reaction cylinder 201 is fixedly connected to a discharge pipe 202. The bottom end of the discharge pipe 202 passes through the cylinder 1 and extends to the bottom of the cylinder 1. The bottom end of the discharge pipe 202 is fixedly connected to a solenoid valve 203. A guide ring 204 is fixedly installed on the inner bottom wall of the cylinder 1. The guide ring 204 can guide the raw materials, and the reaction cylinder 201 can contain the raw materials so that the raw materials can react.
[0028] In one embodiment, please refer to Figure 4 and Figure 5 The amplitude generating component 4 includes a motor 401 mounted on the bottom surface of the reaction cylinder 201. A rotating rod 402 is fixedly mounted on the output end of the motor 401. A connecting block 403 is fixedly mounted on the bottom end of the rotating rod 402. A counterweight 404 is provided on the right side of the connecting block 403. A sliding groove 412 is opened on the left side of the counterweight 404. A connecting plate 408 is slidably mounted on the inner wall of the sliding groove 412. The left end of the connecting plate 408 is fixedly mounted to the right side of the connecting block 403. A set of toothed grooves 409 are opened on the bottom surface of the connecting plate 408. A square tube 4 is fixedly connected to the bottom surface of the counterweight 404. 05. Two strong springs 406 are fixedly installed on the inner bottom wall of the square tube 405. The bottom ends of the two strong springs 406 are fixedly installed with a push block 410. A set of racks 411 is fixedly installed on the top end of the push block 410. The set of racks 411 are adapted to the top ends of a set of toothed grooves 409. Through the cooperation of the strong springs 406, push blocks 410 and racks 411, the racks 411 can cooperate with the toothed grooves 409 and the connecting plate 408 to position the counterweight 404, so that the counterweight 404 can be adjusted in position, thereby generating different amplitudes.
[0029] In one embodiment, please refer to Figure 2 The temperature control component 3 includes a heating ring 301 installed on the outer surface of the reaction cylinder 201, and a temperature sensor 302 fixedly installed on the inner wall of the reaction cylinder 201. The heating ring 301 can heat the inside of the reaction cylinder 201, and the temperature sensor 302 can sense the temperature inside the reaction cylinder 201 and accurately control the temperature inside the reaction cylinder 201.
[0030] In one embodiment, please refer to Figure 2 A sealing ring 6 is fixedly installed on the bottom surface of the reaction cylinder 201. The outer surface of the sealing ring 6 is fixedly installed on the inner wall of the cylinder 1. The internal temperature of the reaction cylinder 201 can be controlled by the sealing ring 6 to prevent the temperature from flowing downward.
[0031] In one embodiment, please refer to Figure 2A set of support columns 5 are fixedly installed on the inner bottom wall of the cylinder 1. The top of each support column 5 is fixedly installed on the bottom surface of the reaction cylinder 201. The support columns 5 can support the reaction cylinder 201 and prevent the reaction cylinder 201 from becoming loose.
[0032] In one embodiment, please refer to Figure 2 A set of support legs 104 are fixedly installed on the bottom surface of the cylinder 1. A control panel 101 is fixedly installed on the upper surface of the cylinder 1. Two feed pipes 102 are fixedly connected to the upper surface of the cylinder 1. A sealing cap 103 is threadedly connected to the outer surface of each feed pipe 102. An opening 105 is opened on the bottom surface of the cylinder 1. Raw materials can be added through the feed pipes 102. The opening 105 can also be used to control the guide block 413, so that the guide block 413 can control the push block 410 to move up and down.
[0033] In one embodiment, please refer to Figure 5 A guide groove 407 is provided on the right side of the square tube 405. A guide block 413 is slidably installed on the inner wall of the guide groove 407. The left end of the guide block 413 is fixedly installed on the right end of the push block 410. A through groove 414 is provided on the upper surface of the slide groove 412. A limiting groove 415 is slidably installed on the inner wall of the through groove 414. The bottom surface of the limiting groove 415 is fixedly installed on the upper surface of the connecting plate 408. The push block 410 can be limited by the guide block 413 and the guide groove 407.
[0034] In one specific embodiment, during use, the sealing cover 103 is opened, opening the feed pipe 102. Raw materials are then added into the device through the feed pipe 102. The heating ring 301 is then activated as needed to bring the raw materials to a set temperature. The motor 401 is then started, causing the rotating rod 402 and connecting block 403 to rotate. This, in turn, causes the connecting plate 408 to rotate the counterweight 404, generating amplitude that vibrates the raw materials inside the reaction cylinder 201, ensuring uniform mixing. To adjust the amplitude, the device is first pulled downwards. The guide block 413 drives the push block 410 downward, which in turn drives the rack 411 downward, allowing the rack 411 to move out of the tooth groove 409. This then pulls the counterweight 404, allowing it to move along the connecting plate 408. After adjustment, the force of the strong spring 406 moves it upward, pushing the push block 410 upward. This causes the rack 411 to move upward, inserting it into the tooth groove 409 and positioning the counterweight 404.
[0035] The above description is only a preferred embodiment of the present utility model and does not limit the patent scope of the present utility model. Any equivalent structural or procedural transformations made based on the content of the present utility model specification and drawings, or direct or indirect applications in other related technical fields, are similarly included within the patent protection scope of the present utility model.
Claims
1. A polypeptide synthesis reactor with adjustable amplitude, characterized in that, The container includes a cylinder (1), inside which a reaction assembly (2) is provided, inside which a temperature control assembly (3) is provided, the heating end of the temperature control assembly (3) is installed outside the container of the reaction assembly (2), and inside which an amplitude generating assembly (4) is provided. The amplitude generating component (4) includes a rotating rod (402), a connecting block (403) is fixedly installed at the bottom end of the rotating rod (402), a counterweight (404) is provided on the right side of the connecting block (403), a square tube (405) is fixedly connected to the bottom surface of the counterweight (404), a pusher (410) is installed inside the square tube (405), a set of racks (411) is fixedly installed at the top end of the pusher (410), and the set of racks (411) is respectively adapted to the top end of a set of tooth grooves (409).
2. The adjustable amplitude peptide synthesis reactor according to claim 1, characterized in that, The reaction assembly (2) includes a reaction cylinder (201) installed on the inner top wall of the cylinder (1). The output end of the reaction cylinder (201) is fixedly connected to a discharge pipe (202). The bottom end of the discharge pipe (202) passes through the cylinder (1) and extends to the bottom of the cylinder (1). The bottom end of the discharge pipe (202) is fixedly connected to a solenoid valve (203). A guide ring (204) is fixedly installed on the inner bottom wall of the cylinder (1).
3. The adjustable amplitude peptide synthesis reactor according to claim 1, characterized in that, The counterweight (404) has a sliding groove (412) on its left side. A connecting plate (408) is slidably installed on the inner wall of the sliding groove (412). The left end of the connecting plate (408) is fixedly installed on the right side of the connecting block (403). A set of toothed grooves (409) is provided on the bottom surface of the connecting plate (408).
4. The adjustable amplitude peptide synthesis reactor according to claim 2, characterized in that, The temperature control component (3) includes a heating ring (301) installed on the outer surface of the reaction cylinder (201), and a temperature sensor (302) is fixedly installed on the inner wall of the reaction cylinder (201).
5. The adjustable amplitude peptide synthesis reactor according to claim 2, characterized in that, A sealing ring (6) is fixedly installed on the bottom surface of the reaction cylinder (201), and the outer surface of the sealing ring (6) is fixedly installed on the inner wall of the cylinder (1).
6. The adjustable amplitude peptide synthesis reactor according to claim 1, characterized in that, A set of support columns (5) are fixedly installed on the inner bottom wall of the cylinder (1), and the top of each support column (5) is fixedly installed on the bottom surface of the reaction cylinder (201).
7. The adjustable amplitude peptide synthesis reactor according to claim 1, characterized in that, A set of support legs (104) is fixedly installed on the bottom surface of the cylinder (1), a control panel (101) is fixedly installed on the upper surface of the cylinder (1), two feed pipes (102) are fixedly connected to the upper surface of the cylinder (1), and a sealing cap (103) is threadedly connected to the outer surface of each feed pipe (102). An opening (105) is opened on the bottom surface of the cylinder (1).
8. The adjustable amplitude peptide synthesis reactor according to claim 3, characterized in that, The right side of the square tube (405) is provided with a guide groove (407), and a guide block (413) is slidably installed on the inner wall of the guide groove (407). The left end of the guide block (413) is fixedly installed with the right end of the push block (410). The upper surface of the slide groove (412) is provided with a through groove (414), and a limiting groove (415) is slidably installed on the inner wall of the through groove (414). The bottom surface of the limiting groove (415) is fixedly installed with the upper surface of the connecting plate (408).
9. The adjustable amplitude peptide synthesis reactor according to claim 1, characterized in that, The amplitude generating component (4) also includes a motor (401) installed on the bottom surface of the reaction cylinder (201). The output end of the motor (401) is connected to the rotating rod (402). A strong spring (406) is fixedly installed on the inner bottom wall of the square tube (405). The bottom end of the strong spring (406) is connected to the push block (410).