Animal ex vivo tissue sample carrier, sample carrying assembly and sampling device

Abstract

The utility model relates to animal in vitro experiment equipment technical field, more particularly to a kind of animal in vitro tissue sample carrier, sample bearing assembly and sampling device.The animal in vitro tissue sample carrier includes placing plate and cover plate, and placing plate is provided with the positioning groove for placing animal in vitro tissue sample;Cover plate is covered in placing plate, and it is provided with the sampling hole corresponding with positioning groove;Wherein, positioning groove and sampling hole are communicated.The animal in vitro tissue sample carrier can improve the uniformity of sample size, to improve the accuracy of experiment.

Description

Technical Field

[0001] This utility model relates to the technical field of animal in vitro experimental equipment, and more specifically, to an animal in vitro tissue sample carrier, sample carrying component and sampling device. Background Technology

[0002] Animal in vitro experiments refer to experimental studies conducted under in vitro conditions after removing animal tissues, organs, or cells from the organism. Although these tissues, organs, or cells have left the organism, they still retain certain physiological functions and structural integrity, and can simulate physiological or pathological processes in vivo to a certain extent.

[0003] However, existing technologies involve manually sampling animal tissues, organs, or cells for experiments, which can lead to inconsistent sample sizes and affect experimental results. Utility Model Content

[0004] The purpose of this invention is to provide an animal ex vivo tissue sample carrier, a sample carrying component, and a sampling device, which can improve the uniformity of sample size and thus improve the accuracy of experiments.

[0005] The embodiments of this utility model can be implemented as follows:

[0006] In a first aspect, this utility model provides an animal ex vivo tissue sample carrier, comprising:

[0007] The placement plate is equipped with positioning slots for placing animal ex vivo tissue samples;

[0008] A cover plate that fits onto the placement plate and has sampling holes corresponding to the positioning slots;

[0009] The positioning groove and the sampling hole are connected.

[0010] In an optional embodiment, the placement plate is provided with a plurality of positioning slots along its length, each positioning slot being used to place an ex vivo animal tissue sample.

[0011] The cover plate has multiple sampling holes along its length, each sampling hole being connected to a positioning groove; or, the cover plate has multiple sampling holes arranged in an array, each positioning groove being connected to multiple sampling holes.

[0012] In an optional embodiment, the placement plate is provided with a positioning part, and the cover plate is provided with a positioning hole. When the cover plate is closed on the placement plate, the positioning part and the positioning hole cooperate.

[0013] In an optional embodiment, a tray is also included, the tray having a receiving cavity and an opening provided at the bottom of the positioning groove;

[0014] The connection between the tray and the placement plate allows the receiving cavity and the positioning slot to communicate through the opening.

[0015] In an optional implementation, there are multiple placement plates and cover plates, with each cover plate covering a corresponding placement plate;

[0016] Each placement board is connected to a tray.

[0017] Secondly, this utility model provides an animal ex vivo tissue sample carrying component, including a loading component, an elastic component, and the aforementioned animal ex vivo tissue sample carrier; the loading component includes a base plate and a support portion, the support portion being connected to the base plate to form a receiving area;

[0018] One end of the elastic element is connected to the support; when the animal ex vivo tissue sample carrier is located in the receiving area, the other end of the elastic element abuts against the cover plate.

[0019] Thirdly, this utility model provides an animal ex vivo tissue sampling device, including a sampling needle, a frame, a storage component, a first movable component, a second movable component, a third movable component, and the aforementioned animal ex vivo tissue sample carrying component;

[0020] The storage component, the first movable component, the second movable component, and the third movable component are all connected to the frame; the first movable component and the second movable component are movably connected to the third movable component; the sampling needle is connected to the first movable component;

[0021] The storage component is used to store animal ex vivo tissues. The first movable component is used to move the sampling needle along a first direction, the second movable component is used to move the sampling needle along a second direction, and the third movable component is used to move the sampling needle along a third direction. The first direction, the second direction, and the third direction are perpendicular to each other.

[0022] In an optional embodiment, the sampling needle includes a body and a push rod, with the body sleeved on the push rod;

[0023] The first movable component includes a chuck, a motor, and a piston sleeve. The motor is connected to the chuck and is used to move the chuck along a first direction to open or close the chuck. The piston is connected to the body.

[0024] When the chuck is closed, it holds the push rod; when the chuck is open, it abuts against the protrusion on the piston.

[0025] In an optional embodiment, the first movable component further includes a sleeve connected to the motor and fitted onto the chuck.

[0026] In an optional embodiment, the storage assembly includes a first storage component, a second storage component, a third storage component, and a connecting plate; the first storage component, the second storage component, and the third storage component are all connected to the connecting plate; the connecting plate is connected to the frame.

[0027] The sampling needle before sampling is stored in the first storage unit; the sampling needle after sampling is stored in the second storage unit; and the sample obtained by the sampling needle is stored in the third storage unit.

[0028] The beneficial effects of the animal ex vivo tissue sample carrier, animal ex vivo tissue sample support assembly, and animal ex vivo tissue sampling device provided in this embodiment of the invention include:

[0029] The animal ex vivo tissue sample holder includes a placement plate and a cover plate. The placement plate is provided with a positioning groove for placing animal ex vivo tissue samples. The cover plate covers the placement plate and is provided with a sampling hole corresponding to the positioning groove. The positioning groove and the sampling hole are connected.

[0030] The animal ex vivo tissue sample holder includes a placement plate and a cover plate. The cover plate closes to the placement plate to connect the sampling hole and the positioning groove, so that the sampling needle can sample the animal ex vivo tissue located in the positioning groove through the sampling hole, thereby replacing manual handling of animal ex vivo tissue, ensuring the uniformity of sample size and improving the accuracy of the experiment. Attached Figure Description

[0031] To more clearly illustrate the technical solutions of the embodiments of this utility model, the drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of this utility model and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0032] Figure 1 This is a schematic diagram of the animal ex vivo tissue sample carrier provided in this embodiment from a first-view perspective;

[0033] Figure 2 This is a schematic diagram of the structure of the placement plate and tray provided in this embodiment;

[0034] Figure 3 This is a schematic diagram of the cover plate provided in this embodiment;

[0035] Figure 4 This is a schematic diagram of the animal ex vivo tissue sample carrier provided in this embodiment from a second perspective.

[0036] Figure 5 This is a cross-sectional schematic diagram of the animal ex vivo tissue sample carrier provided in this embodiment;

[0037] Figure 6 This is a schematic diagram of the structure of the animal ex vivo tissue sample carrier assembly provided in this embodiment;

[0038] Figure 7 for Figure 6 A magnified view of a section at point A in the middle;

[0039] Figure 8 This is a schematic diagram of the animal ex vivo tissue sampling device provided in this embodiment;

[0040] Figure 9 This is a structural diagram of the frame, the first movable component, the second movable component, and the third movable component provided in this embodiment;

[0041] Figure 10 This is a schematic diagram of the structure of the storage component provided in this embodiment;

[0042] Figure 11 This is a partial schematic diagram of the first active component from a first-view perspective provided in this embodiment;

[0043] Figure 12 This is a partial schematic diagram of the first active component from a second perspective provided in this embodiment;

[0044] Figure 13 This is a schematic diagram of the structure of the sampling needle before sampling provided in this embodiment;

[0045] Figure 14 This is a schematic diagram of the structure after sampling by the sampling needle provided in this embodiment.

[0046] Icons: 100-Animal ex vivo tissue sample carrier; 110-Placement plate; 111-Positioning groove; 112-Positioning part; 113-Opening; 120-Cover plate; 121-Sampling hole; 122-Positioning hole; 130-Tray; 131-Receiving cavity; 200-Animal ex vivo tissue sample carrying assembly; 210-Loading component; 211-Base plate; 212-Supporting part; 213-Receiving area; 220-Elastic component; 300-Animal ex vivo tissue sample carrier. Tissue sampling device; 310-Sampling needle; 311-Body; 312-Push rod; 320-Frame; 330-Storage component; 331-First storage component; 332-Second storage component; 333-Third storage component; 334-Connecting plate; 340-First movable component; 341-Clamp; 342-Motor; 343-Piston; 344-Protrusion; 345-Sleeve; 350-Second movable component; 360-Third movable component. Detailed Implementation

[0047] To make the objectives, technical solutions, and advantages of the embodiments of this utility model clearer, the technical solutions of the embodiments of this utility model will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this utility model, and not all embodiments. The components of the embodiments of this utility model described and shown in the accompanying drawings can generally be arranged and designed in various different configurations.

[0048] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but merely to illustrate selected embodiments of the invention. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without inventive effort are within the scope of protection of the present invention.

[0049] It should be noted that similar labels and letters in the following figures indicate similar items. Therefore, once an item is defined in one figure, it does not need to be further defined and explained in subsequent figures.

[0050] In the description of this utility model, it should be noted that if terms such as "upper," "lower," "inner," or "outer" are used to indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship in which the utility model product is usually placed during use, they are only for the convenience of describing this utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this utility model.

[0051] Furthermore, the terms "first" and "second" are used only to distinguish descriptions and should not be interpreted as indicating or implying relative importance.

[0052] It should be noted that, where there is no conflict, the features in the embodiments of this utility model can be combined with each other.

[0053] In existing animal ex vivo experiments, manual sampling is generally performed using tools such as sampling forceps or scissors. During the sampling process, the excised animal tissue is handled by hand. However, this sampling method may result in samples of varying sizes, affecting the experimental results, and it is also labor-intensive and inefficient.

[0054] To solve the above-mentioned technical problems, this utility model provides an animal ex vivo tissue sampling device 300, which includes a frame 320, a sampling needle 310, and an animal ex vivo tissue sample carrier 100 for placing animal ex vivo tissue. The sampling needle 310 is movably connected to the frame 320, and the animal ex vivo tissue sample carrier 100 is connected to the frame 320.

[0055] Please refer to Figures 1-4 , Figure 1 This is a schematic diagram of the animal ex vivo tissue sample carrier 100 provided in this embodiment from a first-view perspective; Figure 2 This is a schematic diagram of the structure of the placement plate 110 and the tray 130 provided in this embodiment; Figure 3 This is a schematic diagram of the structure of the cover plate 120 provided in this embodiment; Figure 4 This is a schematic diagram of the animal ex vivo tissue sample carrier 100 provided in this embodiment from a second perspective.

[0056] In this embodiment, the animal ex vivo tissue sample holder 100 includes a placement plate 110 and a cover plate 120. The placement plate 110 is provided with a positioning groove 111 for placing animal ex vivo tissue samples. The cover plate 120 covers the placement plate 110 and is provided with a sampling hole 121 corresponding to the positioning groove 111. The positioning groove 111 and the sampling hole 121 are connected.

[0057] Specifically, during the installation of the sample carrier, the placement plate 110 and the tray 130 are first connected together, then the animal ex vivo tissue is placed in the positioning groove 111, and finally the cover plate 120 is placed on the placement plate 110, so that the sampling hole 121 is connected to the positioning groove 111, thereby allowing the sampling needle 310 to extend from the sampling hole 121 into the positioning groove 111 to sample the animal ex vivo tissue.

[0058] It should be noted that in this embodiment, the isolated animal tissue is placed in the positioning groove 111 of the placement plate 110 to replace manual support, which facilitates sampling by the sampling needle 310 and ensures the uniformity of sample size. Furthermore, since the cover plate 120 covers the placement plate 110, the position of the isolated animal tissue is limited, preventing the isolated animal tissue from falling out of the positioning groove 111.

[0059] Since the sampling needle 310 is movably connected to the frame 320, the animal ex vivo tissue sample located on the placement plate 110 can be sampled by operating the position of the sampling needle 310; thus, the mechanical activity further ensures that the size of the obtained sample is not affected by human intervention, ensures the uniformity of the sample size, reduces labor costs, and improves sampling efficiency.

[0060] Further, please refer to Figures 1-4 In this embodiment, the placement plate 110 is provided with multiple positioning slots 111 along its length, and each positioning slot 111 is used to place one animal ex vivo tissue sample. Understandably, in order to improve sampling efficiency and to sample multiple animal ex vivo tissues, this embodiment uses multiple positioning slots 111 to place multiple animal ex vivo tissues, thereby allowing sampling of multiple animal ex vivo tissues without changing the animal ex vivo tissue sample holder 100.

[0061] It should be noted that this embodiment uses pig tails for sampling; therefore, the width of the positioning groove 111 decreases sequentially along the width direction of the placement plate 110. Understandably, the shape of the positioning groove 111 can be adaptively adjusted according to the shape of the isolated animal tissue to prevent the isolated animal tissue from detaching from the positioning groove 111.

[0062] Since there are multiple positioning slots 111 in this embodiment, there are also multiple sampling holes 121 in this embodiment. Specifically, the cover plate 120 is provided with multiple sampling holes 121 arranged in an array, and each positioning slot 111 is connected to multiple sampling holes 121.

[0063] Understandably, the multiple sampling holes 121 in the cover plate 120 can be arranged in multiple rows, for example, Figure 4 In the first row, 'a' represents the first row, with each positioning slot 111 connected to multiple sampling holes 121 in a row. This embodiment allows sampling from different locations of the same animal's excised tissue by connecting each positioning slot 111 to multiple sampling holes 121, thereby obtaining more control groups and improving the accuracy of the experiment.

[0064] Based on the above, in order to ensure that the positioning groove 111 can communicate with the multiple sampling holes 121 in the corresponding row during the installation process, the placement plate 110 is provided with a positioning part 112 and the cover plate 120 is provided with a positioning hole 122. When the cover plate 120 is closed on the placement plate 110, the positioning part 112 and the positioning hole 122 cooperate.

[0065] In other embodiments, the cover plate 120 is provided with a plurality of sampling holes 121 along its length, and each sampling hole 121 is connected to a positioning groove 111.

[0066] Further, please refer to Figures 1-5 , Figure 5 This is a cross-sectional schematic diagram of the animal ex vivo tissue sample holder 100 provided in this embodiment. The animal ex vivo tissue sample holder 100 also includes a tray 130, which has a receiving cavity 131 and an opening 113 at the bottom of the positioning groove 111; the tray 130 and the placement plate 110 are connected so that the receiving cavity 131 and the positioning groove 111 are connected through the opening 113.

[0067] It should be noted that before sampling animal tissue, it needs to be treated with physiological saline and nutrient solution. Therefore, some liquid will adhere to the surface of the animal tissue. To prevent the liquid adhering to the surface of the animal tissue from accumulating in the positioning tank 111, the bottom of the positioning tank 111 is provided with an opening 113, so that the liquid can flow out of the positioning tank 111 and into the receiving cavity 131, thereby collecting the liquid adhering to the surface of the animal tissue through the tray 130.

[0068] Understandably, the cover plate 120, the placement plate 110, and the tray 130 are arranged in a vertically stacked manner, and the sampling hole 121, the positioning groove 111, and the receiving cavity 131 are interconnected.

[0069] Based on the above structural configuration, in this embodiment, to prevent the isolated animal tissue from falling into the receiving cavity 131 under the influence of gravity, the width of the opening 113 at the bottom of the positioning groove 111 is smaller than the width of the groove opening. Furthermore, since the experimental subject in this embodiment is a pig tail, the width of the opening 113 should be smaller than the minimum diameter of the pig tail, and the width of the groove opening 111 should be smaller than the maximum diameter of the pig tail. This allows the isolated animal tissue to enter through the groove opening and be placed in the positioning groove 111 without falling into the receiving cavity 131 through the opening 113.

[0070] Specifically, in this embodiment, the cross-section of the positioning groove 111 is V-shaped. In other embodiments, the cross-section of the positioning groove 111 may also be U-shaped or other shapes.

[0071] Please refer to Figures 1-7 , Figure 6 This is a schematic diagram of the structure of the animal ex vivo tissue sample carrier assembly 200 provided in this embodiment; Figure 7 for Figure 6 A magnified view of a portion of point A in the middle.

[0072] This utility model also provides an animal ex vivo tissue sample carrier assembly 200, including a loading component 210 and an animal ex vivo tissue sample carrier 100, wherein the loading component 210 and the animal ex vivo tissue sample carrier 100 are detachably connected.

[0073] Specifically, the loading component 210 can be connected to the frame 320 by welding or other means, thereby enabling the animal ex vivo tissue sample carrier 100 to be detachably connected to the frame 320 using the loading component 210. In other words, the animal ex vivo tissue sampling device 300 in this embodiment includes the frame 320, the sampling needle 310, and the animal ex vivo tissue sample carrying component 200.

[0074] Furthermore, in this embodiment, there are multiple placement plates 110, cover plates 120 and trays 130, with each placement plate 110, cover plate 120 and tray 130 corresponding to one another. Each cover plate 120 covers the corresponding placement plate 110, and each tray 130 is connected to the corresponding placement plate 110.

[0075] Understandably, the animal ex vivo tissue sampling device 300 has multiple animal ex vivo tissue sample holders 100, all of which are connected to the loading component 210, thereby sampling multiple different animal ex vivo tissues to obtain more samples, improve sampling efficiency, and improve the accuracy of the experiment by adding a control group.

[0076] In other embodiments, only one tray 130 may be provided, with each placement plate 110 connected to the tray 130.

[0077] Furthermore, the animal ex vivo tissue sample carrier assembly 200 also includes an elastic element 220; the loading element 210 includes a base plate 211 and a support portion 212, the support portion 212 being connected to the base plate 211 to form a receiving area 213; one end of the elastic element 220 is connected to the support portion 212; when the animal ex vivo tissue sample carrier 100 is located in the receiving area 213, the other end of the elastic element 220 abuts against the cover plate 120.

[0078] Specifically, during the installation of the animal ex vivo tissue sample holder 100, the animal ex vivo tissue sample holder 100 can be slid to allow it to enter the receiving area 213. It should be noted that the receiving area 213 is slightly lower than other areas. Therefore, as the animal ex vivo tissue sample holder 100 moves towards the receiving area 213, the cover plate 120 abuts against the elastic member 220, causing the elastic member 220 to contract. After the animal ex vivo tissue sample holder 100 reaches the receiving area 213, the elastic member 220 returns to its original position under its own elastic force, and still abuts against the cover plate 120.

[0079] It should be noted that the support part 212 is not only used to connect the elastic element 220, but also to restrict the movement of the animal ex vivo tissue sample carrier 100, thereby ensuring the smooth progress of sampling and preventing the animal ex vivo component from moving during the sampling process, which would cause the sampling needle 310 to be unable to obtain the sample.

[0080] In other embodiments, the loading member 210 is provided with a receiving area 213 and a magnetic suction part. When the loading member 210 is located in the receiving area 213, the loading member 210 is connected to the animal ex vivo tissue sample carrier 100 through the magnetic suction part.

[0081] Please refer to Figures 1-14 , Figure 8 This is a schematic diagram of the structure of the animal ex vivo tissue sampling device 300 provided in this embodiment; Figure 9 This is a structural schematic diagram of the frame 320, the first movable component 340, the second movable component 350, and the third movable component 360 provided in this embodiment; Figure 10 This is a schematic diagram of the structure of the storage component 330 provided in this embodiment; Figure 11This is a partial schematic diagram of the first active component 340 from a second perspective provided in this embodiment; Figure 12 This is a partial schematic diagram of the first active component 340 from a first-view perspective provided in this embodiment; Figure 13 This is a schematic diagram of the structure of the sampling needle 310 before sampling provided in this embodiment; Figure 14 This is a schematic diagram of the structure after sampling by the sampling needle 310 provided in this embodiment.

[0082] The animal ex vivo tissue sampling device 300 in this embodiment further includes a first movable component 340, a second movable component 350, and a third movable component 360 connected to the frame 320. The first movable component 340 is connected to the sampling needle 310 and can drive the sampling needle 310 to move along a first direction. The first movable component 340 and the second movable component 350 are both movably connected to the third movable component 360. The second movable component 350 can drive the first movable component 340, the third movable component 360, and the sampling needle 310 to move along a second direction, and the third movable component 360 can drive the first movable component 340 and the sampling needle 310 to move along a third direction.

[0083] Furthermore, the animal ex vivo tissue sampling device 300 also includes a storage component 330, which has a first storage element 331, a second storage element 332, a third storage element 333, and a connecting plate 334. The first storage element 331, the second storage element 332, and the third storage element 333 are all connected to the connecting plate 334, and each has the same number of storage holes as the sampling holes 121. The multiple storage holes on each storage element correspond one-to-one with the multiple sampling holes 121.

[0084] The first storage unit 331 is used to store the sampling needle 310 before sampling, the second storage unit 332 is used to store the sampling needle 310 after sampling, and the third storage unit 333 is used to store the sample obtained after sampling. Understandably, the number of sampling needles 310 is the same as the number of sampling holes 121, and they correspond one-to-one.

[0085] In this embodiment, the sampling needle 310 is moved to the first storage chamber by the first movable component 340, the second movable component 350 and the third movable component 360, the sampling needle 310 is taken out, and then the sampling needle 310 is moved to the sample carrier so that the sampling needle 310 can be inserted into the corresponding sampling hole 121 to sample the animal ex vivo tissue in the sampling hole 121, thereby obtaining a sample.

[0086] After obtaining the sample, the first movable component 340, the second movable component 350, and the third movable component 360 move the sampling needle 310 to the third storage unit 333, placing the obtained sample into the corresponding storage hole in the third storage unit 333 for storage. Finally, the sampling needle 310 is moved from the third storage unit 333 to the second storage unit 332 to store the sampled sample.

[0087] It should be noted that in this embodiment, both the second movable component 350 and the third movable component 360 are lead screw structures. In other embodiments, the second movable component 350 and the third movable component 360 may also adopt other linear sliding structures.

[0088] The first movable component 340 includes a chuck 341 and a motor 342. The chuck 341 is connected to the motor 342. The motor 342 can drive the chuck 341 to move along a first direction, so that the chuck 341 can move between a first position and a second position. When the chuck 341 is in the first position, the chuck 341 is open, and when the chuck 341 is in the second position, the chuck 341 is closed.

[0089] The sampling needle 310 in this embodiment includes a body 311 and a push rod 312. The body 311 in this embodiment has a hollow structure and is sleeved on the push rod 312. The body 311 in this embodiment has four blades, while in other embodiments the body 311 may have three blades. The appropriate body 311 can be selected according to the actual situation.

[0090] According to the above, in this embodiment, the first movable component 340 further includes a driver, a piston 343, and a sleeve 345. The driver is connected to the motor 342, the chuck 341, the piston 343, and the sleeve 345, and can drive the motor 342, the chuck 341, the piston 343, and the sleeve 345 to move along the first direction.

[0091] It should be noted that the piston 343 is provided with a protrusion 344. The motor 342 drives the chuck 341 to move downward to approach the protrusion 344. After the chuck 341 and the protrusion 344 come into contact, the chuck 341 can be opened due to the compression of the protrusion 344. That is, when the chuck 341 is in the first position, the chuck 341 abuts against the protrusion 344.

[0092] Understandably, as the chuck 341 moves from the first position to the second position, it moves upward, gradually moving away from the protrusion 344, thus changing from an open state to a closed state. Therefore, when it is necessary to grip the sampling needle 310, the motor 342 first drives the chuck 341 closer to the protrusion 344 to open the chuck 341, allowing the push rod 312 to extend into the chuck 341. Subsequently, the motor 342 drives the chuck 341 away from the protrusion 344, causing the chuck 341 to gradually close to grip the push rod 312.

[0093] In this embodiment, piston 343 is connected to body 311. Specifically, the diameter of one end of body 311 is larger than the diameter of piston 343, allowing piston 343 to abut against the inner wall of body 311. This enables piston 343 to engage with body 311, allowing the actuator to drive piston 343 and body 311 to move together in the first direction. Furthermore, the connection between piston 343 and body 311 allows sampling needle 310 to be retrieved from the first storage chamber. Piston 343 is provided with a clearance hole for push rod 312 to pass through, preventing push rod 312 from interfering with the connection between piston 343 and body 311.

[0094] It should be noted that after sampling is completed, the sampling needle 310 needs to be placed in the second storage container 332. Therefore, the sampling needle 310 needs to be removed from the piston 343. In this embodiment, a sleeve 345 is provided that is sleeved on the chuck 341, so that the sleeve 345 can move along the first direction under the drive of the motor 342, and then abut against the body 311. After the sleeve 345 abuts against the body 311, it continues to move downward, so that the body 311 is disengaged from the piston 343 by force.

[0095] Based on the above, the installation steps for the animal ex vivo tissue sampling device 300 are as follows:

[0096] First, multiple animal ex vivo tissues of the same type are placed in multiple positioning slots 111 of the placement plate 110 at one time. Then, the plate 120 is covered on the placement plate 110 so that the sampling hole 121 and the positioning slots 111 are connected, and the tray 130 and the placement plate 110 are connected together.

[0097] Next, the assembled animal ex vivo tissue sample carrier 100 is placed in the receiving area 213 so that the elastic space can abut against the cover plate 120, thereby fixing the animal ex vivo sample carrier.

[0098] Finally, the assembled animal ex vivo tissue sample carrier assembly 200 is connected to the frame 320, and the storage assembly 330, the first movable assembly 340, the second movable assembly 350, and the third movable assembly 360 are installed on the frame 320. The storage assembly 330 stores unused sampling needles 310.

[0099] The working principle of the animal ex vivo tissue sampling device 300 is as follows:

[0100] The first step is to remove the sampling needle 310 located in the first storage chamber;

[0101] First, the motor 342 drives the chuck 341 to move downward in the first direction, so that the chuck 341 moves to the first position and abuts against the protrusion 344; after the chuck 341 abuts against the protrusion 344, it changes from the closed state to the open state.

[0102] Next, the driver drives the motor 342, chuck 341, piston 343 and sleeve 345 to move the piston 343 downward to approach the body 311. During the approach, the push rod 312 passes through the through hole of the piston 343 and extends into the chuck 341. Then, the body 311 and the piston 343 are snapped together.

[0103] Finally, the motor 342 drives the chuck 341 to move upward from the first position to the second position, thereby gradually closing the chuck 341. Since the push rod 312 is located inside the chuck 341, the chuck 341 is able to hold the push rod 312.

[0104] The second step is to sample the animal's isolated tissues;

[0105] After connecting the sampling needle 310, the second movable component 350 and the second movable component 350 drive the first movable component 340 to move, moving the first movable component 340 from the storage component 330 to the animal ex vivo tissue sample holder 100; and aligning the sampling needle 310 with the corresponding sampling hole 121.

[0106] Subsequently, the actuator drives the sampling needle 310 to move downward, so that the body 311 comes into contact with the animal ex vivo tissue, thereby cutting the animal ex vivo tissue to obtain a sample.

[0107] Finally, after the cutting is completed, the driver drives the sampling needle 310 to move upward, so that the sampling needle 310 leaves the animal ex vivo tissue sample holder 100.

[0108] The third step is to store the obtained samples in the third storage device 333;

[0109] After obtaining the sample, the first movable component 340 and the sampling needle 310 are moved from the animal ex vivo tissue sample holder 100 to the storage component 330 using the second movable component 350 and the third movable component 360, so that the sampling needle 310 is aligned with the corresponding storage hole in the third storage component 333. The motor 342 drives the chuck 341 and the push rod 312 to move downward in the first direction, so that the push rod 312 moves downward relative to the body 311, allowing the push rod 312 to push the sample located at the blade of the body 311, so that the sample leaves the body 311 and enters the storage hole.

[0110] The fourth step is to store the sampled needle 310 in the second storage unit 332.

[0111] After the sample is stored, the first movable component 340 and the sampling needle 310 are moved from the third storage unit 333 to the second storage unit 332 using the second movable component 350 and the third movable component 360, and the sampling needle 310 is aligned with the corresponding storage hole in the second storage unit 332.

[0112] Motor 342 drives chuck 341 to move chuck 341 to a first position, thereby causing chuck 341 to abut against protrusion 344 to open chuck 341. Next, motor 342 continues to drive chuck 341 and sleeve 345 to move downward, causing sleeve 345 to abut against body 311; under the drive of motor 342, body 311 is subjected to a downward force, enabling body 311 to disengage from piston 343 and enter the storage hole of second storage member 332.

[0113] It should be noted that both the second active component 350 and the second active component 350 are provided with separate drivers to drive the first active component 340 to move along the second direction and the third direction, respectively.

[0114] In other embodiments, a plastic filament can be used instead of the push rod 312 in this embodiment. The plastic filament can be driven to move relative to the sampling needle 310 by a filament feeder. In this way, the body 311 can be unloaded directly during the unloading of the sampling needle 310 without unloading the plastic filament.

[0115] However, before unloading the main body 311, since the front end of the plastic filament protrudes slightly relative to the main body 311, an automatic cutting mechanism is needed to cut off the front end of the plastic filament before removing the sampling needle 310. In summary, this embodiment provides an animal ex vivo tissue sampling device including a frame 320, a sampling needle 310, and an animal ex vivo tissue sample carrying assembly 200. The animal ex vivo tissue sample carrying assembly 200 is connected to the frame 320, and the sampling needle 310 is movably connected to the frame 320. This utilizes the mechanical movement of the sampling needle 310 to replace manual operation, saving labor costs and improving sampling efficiency.

[0116] The animal ex vivo tissue sample carrier assembly 200 uses the elastic force of the elastic element 220 to fix the animal ex vivo tissue sample carrier 100 after it enters the receiving area 213. At the same time, since the elastic element 220 can contract, the animal ex vivo tissue sample carrier 100 can be detachably installed on the loading component 210.

[0117] The animal ex vivo tissue sample holder 100 includes a placement plate 110 and a cover plate 120. The cover plate 120 opens and closes to the placement plate 110 so that the sampling hole 121 and the positioning groove 111 are connected, thereby allowing the sampling needle 310 to sample the animal ex vivo tissue located in the positioning groove 111 through the sampling hole 121, so as to replace manual handling of animal ex vivo tissue, ensure the uniformity of sample size, and improve the accuracy of the experiment.

[0118] The above description is only a specific embodiment of this utility model, but the protection scope of this utility model is not limited thereto. Any changes or substitutions that can be easily conceived by those skilled in the art within the technical scope disclosed in this utility model should be included within the protection scope of this utility model.

Claims

1. A specimen carrier for ex vivo animal tissue samples, characterized in that, include: Placement plate (110), the placement plate (110) is provided with a positioning groove (111) for placing animal ex vivo tissue samples. A cover plate (120) is provided to cover the placement plate (110) and has a sampling hole (121) corresponding to the positioning groove (111). The positioning groove (111) and the sampling hole (121) are connected.

2. The animal ex vivo tissue sample carrier according to claim 1, characterized in that, The placement plate (110) is provided with a plurality of positioning slots (111) along its length, and each positioning slot (111) is used to place one of the animal ex vivo tissue samples; The cover plate (120) is provided with a plurality of sampling holes (121) along its length direction, and each sampling hole (121) is connected to a positioning groove (111); or, the cover plate (120) is provided with a plurality of sampling holes (121) arranged in an array, and each positioning groove (111) is connected to a plurality of sampling holes (121).

3. The animal ex vivo tissue sample holder according to claim 1, characterized in that, The placement plate (110) is provided with a positioning part (112), and the cover plate (120) is provided with a positioning hole (122). When the cover plate (120) covers the placement plate (110), the positioning part (112) and the positioning hole (122) cooperate.

4. The animal ex vivo tissue sample carrier according to claim 1, characterized in that, It also includes a tray (130) having a receiving cavity (131) and an opening (113) at the bottom of the positioning groove (111). The tray (130) and the placement plate (110) are connected so that the receiving cavity (131) and the positioning groove (111) are connected through the opening (113).

5. The animal ex vivo tissue sample holder according to claim 4, characterized in that, There are multiple placement plates (110) and cover plates (120), and each cover plate (120) covers a corresponding placement plate (110). Each of the placement plates (110) is connected to the tray (130).

6. A sample carrier component, characterized in that, It includes a loading component (210), an elastic component (220), and an animal ex vivo tissue sample carrier (100) as described in any one of claims 1-5; The loading member (210) includes a base plate (211) and a support (212), the support (212) being connected to the base plate (211) to form a receiving area (213). One end of the elastic element (220) is connected to the support (212); when the animal ex vivo tissue sample carrier (100) is located in the receiving area (213), the other end of the elastic element (220) abuts against the cover plate (120).

7. A sampling device, characterized in that, It includes a sampling needle (310), a frame (320), a storage assembly (330), a first movable assembly (340), a second movable assembly (350), a third movable assembly (360), and a load-bearing assembly as described in claim 6; The storage component (330), the first movable component (340), the second movable component (350), and the third movable component (360) are all connected to the frame (320); the first movable component (340) and the second movable component (350) are movably connected to the third movable component (360); the sampling needle (310) is connected to the first movable component (340). The storage component (330) is used to store animal ex vivo tissue, the first movable component (340) is used to move the sampling needle (310) along a first direction, the second movable component (350) is used to move the sampling needle (310) along a second direction, and the third movable component (360) is used to move the sampling needle (310) along a third direction; the first direction, the second direction and the third direction are perpendicular to each other.

8. The sampling device according to claim 7, characterized in that, The sampling needle (310) includes a body (311) and a push rod (312), with the body (311) sleeved on the push rod (312). The first movable component (340) includes a chuck (341), a motor (342), and a piston (343). The motor (342) is connected to the chuck (341) and is used to drive the chuck (341) to move along the first direction to open or close the chuck (341). The piston (343) is connected to the body (311). When the chuck (341) is closed, the chuck (341) holds the push rod (312); when the chuck (341) is open, the chuck (341) abuts against the protrusion (344) provided on the piston (343).

9. The sampling device according to claim 8, characterized in that, The first movable component (340) also includes a sleeve (345), which is connected to the motor (342) and is fitted onto the chuck (341).

10. The sampling device according to claim 7, characterized in that, The storage assembly (330) includes a first storage component (331), a second storage component (332), a third storage component (333), and a connecting plate (334); the first storage component (331), the second storage component (332), and the third storage component (333) are all connected to the connecting plate (334); the connecting plate (334) is connected to the frame (320); Before sampling, the sampling needle (310) is stored in the first storage unit (331); after sampling, the sampling needle (310) is stored in the second storage unit (332); and the sample obtained by the sampling needle (310) is stored in the third storage unit (333).

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