Experimental apparatus
By introducing robots and optimizing the clamping mechanism into the experimental equipment, the problems of high error rate and low efficiency in the sample transfer and collection process were solved, and efficient automated sample processing was achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- PEKING UNIV SHENZHEN GRADUATE SCHOOL
- Filing Date
- 2025-07-28
- Publication Date
- 2026-07-14
AI Technical Summary
The sample extraction process in the laboratory has a high error rate and low efficiency, especially in the sample transfer and collection stages, which rely on manual operation.
Design an experimental device including a base plate, a finished product rack, a rotary evaporator, a column chromatography apparatus, and a robot. By setting positioning blocks and clamping mechanisms at the mouth of the collection bottle, the robot is used to replace manual labor to complete the transfer and collection of samples. The gripper structure of the clamping mechanism is optimized to ensure accurate and reliable clamping of the collection bottle.
It reduces the error rate in sample transfer and collection, improves work efficiency, and achieves sample separation and purification through rotary evaporation, thereby enhancing the automation level of the experimental process.
Smart Images
Figure CN224486101U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of experimental equipment technology, and in particular to an experimental device. Background Technology
[0002] In the laboratory, sample extraction is mainly achieved through chromatographic purification and rotary evaporation. Chromatographic purification is used to separate and purify the components in the stock solution, separating different components in the mixture based on their distribution coefficients in the stationary and mobile phases using a chromatographic column. Rotary evaporation is used to evaporate the solvent, separating and purifying the sample. However, the sample extraction process suffers from technical problems such as high error rates and low efficiency.
[0003] Therefore, it is necessary to provide a new experimental device to solve the above-mentioned technical problems. Utility Model Content
[0004] The main purpose of this invention is to provide an experimental device that aims to solve the technical problems of high error rate and low work efficiency in the sample extraction process.
[0005] To achieve the above objectives, this utility model proposes an experimental device comprising a base plate, a finished product rack, a first placement rack, a rotary evaporator, a first robot, and a column chromatography device. The first robot is disposed on the base plate. The finished product rack, the first placement rack, the rotary evaporator, and the column chromatography device are arranged circumferentially around the first robot. The first placement rack holds at least one collection bottle. The first robot is used to transfer each collection bottle between the finished product rack, the first placement rack, the rotary evaporator, and the column chromatography device.
[0006] Each of the collection bottles has a positioning block at its mouth, and the positioning block has an annular insert. The first robot has a gripping mechanism, which includes a gripper with a slot. When the gripping mechanism is at the mouth of the collection bottle, the gripper can move toward the positioning block so that the insert is inserted into the slot and clamps the positioning block.
[0007] In one embodiment, the clamping mechanism further includes a base and a drive cylinder. The base is disposed on the first robot, and the drive cylinder is disposed on the base. The number of grippers is two, and both grippers are disposed on the drive cylinder. The drive cylinder can drive the two grippers to move in a direction that is closer to or further away from each other.
[0008] In one embodiment, two rollers are spaced apart on each side of the two grippers facing each other, and annular grooves are provided on the outer circumferential surfaces of the two rollers. The slot includes two annular grooves.
[0009] When the clamping mechanism is at the bottle mouth position of the collection bottle, the drive cylinder can drive the two grippers to move towards each other, so that one side of the insert block is simultaneously inserted into the two annular grooves of one of the grippers, and the other side of the insert block is simultaneously inserted into the two annular grooves of the other gripper, and the outer circumferential surface of each roller abuts against the positioning block to clamp the positioning block.
[0010] In one embodiment, the slots are provided on the sides of the two grippers that face each other, and the sides of each gripper that face each other are recessed in a direction away from each other to form a groove.
[0011] When the clamping mechanism clamps the positioning block, a portion of the positioning block is accommodated in the groove, and the positioning block abuts against the inner wall surface of the groove.
[0012] In one embodiment, the collection bottle includes at least a first collection bottle and a second collection bottle, wherein the volume of the first collection bottle is greater than the volume of the second collection bottle; the experimental equipment further includes a cleaning rack, which is provided with a first drive pump, a second drive pump, a liquid suction block, a liquid discharge block, a spray block, a first mounting position for placing the first collection bottle and a second mounting position for placing the second collection bottle, wherein the liquid suction block, the liquid discharge block and the spray block are all provided with annular inserts, the liquid suction block is provided with a liquid suction needle, the liquid suction block and the liquid discharge block are both connected to the first drive pump, and the spray block is connected to the second drive pump;
[0013] The first robot is used to grip and transfer the first collection bottle, the second collection bottle, the liquid suction block, the liquid drainage block, and the spray block; the first drive pump is used to extract the sample mixture in the first collection bottle into the second collection bottle when the liquid suction needle of the liquid suction block is inserted into the first collection bottle and the liquid drainage block is inserted into the bottle mouth of the second collection bottle; the second drive pump is used to extract the cleaning solution into the first collection bottle when the spray block is inserted into the bottle mouth of the first collection bottle.
[0014] In one embodiment, the liquid suction block is connected to the first drive pump via a first hose, and the liquid discharge block is connected to the first drive pump via a second hose. Both the first hose and / or the second hose are equipped with bubble sensors.
[0015] In one embodiment, the column chromatography apparatus includes an assembly platform, a second placement rack, a delivery pump, a transfer rack, and a second robot. The second robot is disposed on the base plate. The assembly platform, the second placement rack, and the transfer rack are arranged circumferentially around the second robot. The second placement rack holds a chromatographic column. The second robot is used to transfer the chromatographic column between the assembly platform and the second placement rack. The transfer rack is provided with an outlet and a third mounting position located below the outlet for placing a collection bottle.
[0016] The assembly table includes a frame, a slider, a first mounting plate, a second mounting plate, a drive component, and a clamping assembly. The first mounting plate is disposed on the frame, and the second mounting plate is slidably disposed below the first mounting plate along the height direction of the frame. The slider is slidably disposed between the first mounting plate and the second mounting plate along the height direction of the frame. The drive component is disposed on the slider and connected to the second mounting plate. The clamping assembly is disposed on the slider and used to clamp the chromatographic column. The first mounting plate is provided with a liquid injection connector communicating with the delivery pump, and the second mounting plate is provided with... The system includes a liquid outlet connector communicating with the liquid outlet head; the slider can move along the height direction of the frame towards the first mounting plate when the clamping assembly holds the chromatographic column, so that the first end of the chromatographic column is connected to the liquid injection connector; the driving member can drive the second mounting plate to slide when the first end of the chromatographic column is connected to the liquid injection connector, so that the second end of the chromatographic column is connected to the liquid outlet connector; the delivery pump is used to draw the stock solution into the chromatographic column when the first end of the chromatographic column is connected to the liquid injection connector and the second end of the chromatographic column is connected to the liquid outlet connector.
[0017] In one embodiment, both the injection connector and the outlet connector are provided with an adapter block, the adapter block is provided with a guide hole, and the end of the guide hole near the clamping assembly is provided with a guide cone surface.
[0018] In one embodiment, the experimental apparatus further includes a chromatograph, which includes a main body, a plurality of test tubes disposed on the main body, and a plurality of injection pumps that are connected to each of the plurality of test tubes in a one-to-one correspondence. The injection pumps include a liquid aspiration state and a liquid dispensing state.
[0019] When the syringe pump is in the liquid aspiration state, the chromatographic column and the test tube are connected through the syringe pump; when the syringe pump is in the liquid discharging state, the test tube and the liquid outlet are connected through the syringe pump.
[0020] In one embodiment, a weight sensor is provided on the bottom surface of both the finished product rack and the first placement rack.
[0021] The technical solution of this utility model, by setting an annular insertion block on the positioning block at the mouth of the collection bottle and providing slots for the insertion block to be inserted into the gripper, enables the clamping mechanism to clamp the collection bottle more accurately and reliably. Thus, a robot can replace manual labor in sample transfer and collection, reducing error rates and improving work efficiency. In this embodiment, the column chromatography device is used to separate and purify the components in the stock solution to achieve sample extraction; the rotary evaporator evaporates the solvent in the collection bottle through rotary evaporation to achieve sample separation and purification. The first robot is used to transfer the collection bottle between the finished product rack, the first placement rack, the rotary evaporator, and the column chromatography device to complete sample transfer and collection. Each collection bottle has a positioning block at its neck, and each positioning block has a ring-shaped insert. The gripping mechanism of the first robot includes grippers with slots for the inserts. When the gripping mechanism holds the collection bottle, inserting the inserts into the slots better restricts and locks the position of the collection bottle, allowing the gripping mechanism to hold the collection bottle more accurately and securely, preventing it from falling during transfer. This experimental device, by optimizing the bottle neck structure and the gripper structure of the clamping mechanism, enables the first robot's gripping mechanism to hold the positioning blocks of the collection bottle more accurately and securely, preventing the collection bottle from falling during transfer. Furthermore, this experimental device uses the first robot to replace manual transfer of collection bottles, completing sample transfer and collection, which reduces the error rate during the experiment and improves work efficiency. This experimental device is applied in the fields of laboratory automation and fine chemical engineering equipment, specifically in automated sample processing workflows in chemistry, biology, medicine, and materials science. Attached Figure Description
[0022] To more clearly illustrate the technical solutions in the embodiments of this utility model or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this utility model. For those skilled in the art, other drawings can be obtained based on the structures shown in these drawings without creative effort.
[0023] Figure 1 A schematic diagram of the experimental equipment in one embodiment of this utility model;
[0024] Figure 2 A schematic diagram of the structure of the cleaning rack in one embodiment of this utility model;
[0025] Figure 3 A schematic diagram of the structure of the second collection bottle in one embodiment of this utility model;
[0026] Figure 4 A schematic diagram of the clamping mechanism in one embodiment of the present utility model;
[0027] Figure 5 A schematic diagram of the clamping mechanism in another embodiment of this utility model;
[0028] Figure 6 A schematic diagram of the assembly table in one embodiment of the present invention;
[0029] Figure 7 A cross-sectional view of the injection connector in one embodiment of this utility model.
[0030] Explanation of icon numbers:
[0031] 100. Base plate; 200. Finished product rack; 300. First placement rack; 310. First collection bottle; 320. Second collection bottle; 321. Positioning block; 3211. Insert block; 400. Rotary evaporator; 500. First robot; 510. Clamping mechanism; 511. Gripper; 5111. Slot; 5112. Roller; 5113. Annular groove; 5114. Groove; 512. Base; 513. Drive cylinder; 600. Column chromatography apparatus; 610. Assembly table; 611. Frame; 612. Slide Block; 613, First mounting plate; 6131, Liquid injection connector; 614, Second mounting plate; 615, Drive component; 616, Clamping assembly; 617, Adapter block; 6171, Guide hole; 6172, Guide cone surface; 620, Second placement rack; 621, Chromatographic column; 630, Second robot; 700, Cleaning rack; 710, Second drive pump; 720, Liquid suction block; 721, Liquid suction needle; 730, Liquid discharge block; 740, Spray block; 750, First mounting position; 760, Second mounting position.
[0032] The realization of the purpose, functional features and advantages of this utility model will be further explained in conjunction with the embodiments and with reference to the accompanying drawings. Detailed Implementation
[0033] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0034] It should be noted that all directional indicators (such as up, down, left, right, front, back, etc.) in this utility model embodiment are only used to explain the relative positional relationship and movement of each component in a certain specific posture (as shown in the figure). If the specific posture changes, the directional indicator will also change accordingly.
[0035] Furthermore, if the embodiments of this utility model involve descriptions such as "first" or "second," these descriptions are for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features. Additionally, if "and / or" or "and / or" appears throughout the text, its meaning includes three parallel solutions. For example, "A and / or B" includes solution A, solution B, or a solution where both A and B are satisfied simultaneously.
[0036] Furthermore, the technical solutions of the various embodiments of this utility model can be combined with each other, but only if they are based on the ability of those skilled in the art to implement them. When the combination of technical solutions is contradictory or cannot be implemented, it should be considered that such combination of technical solutions does not exist and is not within the protection scope claimed by this utility model.
[0037] In the laboratory, sample extraction is mainly achieved through chromatographic purification and rotary evaporation. Chromatographic purification is used to separate and purify the components in the stock solution, separating different components in the mixture based on their distribution coefficients in the stationary and mobile phases using a chromatographic column. Rotary evaporation is used to evaporate the solvent, separating and purifying the sample. In practice, researchers have found that after chromatographic purification, the sample needs to be transferred to a rotary evaporator for concentration. However, sample transfer and collection mainly rely on manual labor, which suffers from high error rates and low efficiency.
[0038] This invention proposes an experimental device aimed at solving the technical problems of high error rate and low work efficiency in the sample extraction process.
[0039] Please see Figure 1 , Figure 3 , Figure 4 and Figure 5In one embodiment of this utility model, the experimental equipment includes a base plate 100, a finished product rack 200, a first placement rack 300, a rotary evaporator 400, a first robot 500, and a column chromatography device 600. The first robot 500 is disposed on the base plate 100. The finished product rack 200, the first placement rack 300, the rotary evaporator 400, and the column chromatography device 600 are arranged circumferentially around the first robot 500. The first placement rack 300 holds at least one collection bottle. The first robot 500 is used to move the finished product rack 200, the first placement rack 300, the rotary evaporator 400, and the column chromatography device 600 around the base plate 100. The collection bottles are transferred between the evaporation apparatus 400 and the column chromatography apparatus 600. Each collection bottle has a positioning block 321 at its neck, and the positioning block 321 has an annular insertion block 3211. The first robot 500 is equipped with a clamping mechanism 510, which includes a gripper 511 with a slot 5111. When the clamping mechanism 510 is in the position of the collection bottle neck, the gripper 511 can move towards the positioning block 321 so that the insertion block 3211 is inserted into the slot 5111 and the positioning block 321 is clamped. In a specific embodiment, the first robot 500 can be a multi-degree-of-freedom manipulator.
[0040] The technical solution of this utility model, by setting an annular insertion block 3211 on the positioning block 321 at the mouth of the collection bottle, and setting a slot 5111 for the insertion block 3211 to be inserted into the gripper 511, enables the clamping mechanism 510 to clamp the collection bottle more accurately and reliably. Thus, a robot can replace manual labor in sample transfer and collection, reducing error rates and improving work efficiency. In this embodiment, the column chromatography device 600 is used to separate and purify the components in the stock solution to achieve sample extraction; the rotary evaporator 400 evaporates the solvent in the collection bottle through rotary evaporation to achieve sample separation and purification. The first robot 500 is used to transfer the collection bottle between the finished product rack 200, the first placement rack 300, the rotary evaporator 400, and the column chromatography device 600 to complete sample transfer and collection. Each collection bottle has a positioning block 321 at its mouth, and the positioning block 321 has an annular insertion block 3211. The clamping mechanism 510 of the first robot 500 includes a gripper 511, and the gripper 511 has a slot 5111 for the insertion block 3211 to be inserted. When the clamping mechanism 510 clamps the collection bottle, inserting the insertion block 3211 into the slot 5111 can better restrict and lock the position of the collection bottle, so that the clamping mechanism 510 can clamp the collection bottle more accurately and securely, and prevent the collection bottle from falling during the transfer process. By optimizing the bottle mouth structure of the collection bottle and the gripper 511 structure of the clamping mechanism 510, this experimental device enables the clamping mechanism 510 of the first robot 500 to clamp the positioning block 321 of the collection bottle more accurately and securely, preventing the collection bottle from falling during the transfer process. Furthermore, this experimental device uses a robot to replace manual transfer of the collection bottle to complete the transfer and collection of samples, which can reduce the error rate of the experimental device during the experiment and improve work efficiency. This experimental equipment is applied in the fields of laboratory automation and fine chemical engineering equipment, and can be specifically applied to automated sample processing procedures in the fields of chemistry, biology, medicine, and materials.
[0041] It should be noted that the rotary evaporator 400 in this embodiment is a rotary evaporator, which is mainly used for continuous distillation of volatile solvents under reduced pressure to separate and purify samples. The rotary evaporator 400 includes a rotary motor, a heating pot, a condenser, a vacuum pump, a receiving bottle, and a lifting mechanism. The rotary motor is installed on the lifting mechanism and is provided with a mounting block for inserting the receiving bottle. The heating pot is located directly below the rotary motor, and the lifting mechanism is used to drive the rotary motor to move up and down. During rotary evaporation, the first robot 500 first transfers the collection bottle containing the sample mixture separated and purified by the column chromatography device 600 to the mounting block, and inserts the mounting block into the collection bottle to fix it in place. Then, the lifting mechanism drives the rotary motor to descend until part of the collection bottle is placed in the water of the heating pot. The rotary motor drives the collection bottle to rotate, and at the same time, the vacuum pump extracts space inside the collection bottle to reduce the pressure, which allows the solvent to evaporate rapidly. The evaporated solvent vapor enters the condenser through the evaporation pipe, is condensed into liquid, and flows into the receiving bottle. In this way, the solvent in the collection bottle is evaporated, completing the separation and purification of the sample.
[0042] Please see Figure 1 and Figure 2In one embodiment of this utility model, the collection bottle includes at least a first collection bottle 310 and a second collection bottle 320, with the volume of the first collection bottle 310 being larger than the volume of the second collection bottle 320. The experimental equipment also includes a cleaning rack 700, which is equipped with a first drive pump, a second drive pump 710, a suction block 720, a drain block 730, a spray block 740, a first mounting position 750 for placing the first collection bottle 310, and a second mounting position 760 for placing the second collection bottle 320. The suction block 720, drain block 730, and spray block 740 are all provided with annular inserts 3211. The suction block 720 is equipped with suction needles 721. All drain blocks 730 are connected to the first drive pump, and the spray block 740 is connected to the second drive pump 710. The first robot 500 is used to clamp and transfer the first collection bottle 310, the second collection bottle 320, the suction block 720, the drain block 730, and the spray block 740. The first drive pump is used to extract the sample mixture in the first collection bottle 310 into the second collection bottle 320 when the suction needle 721 of the suction block 720 is inserted into the first collection bottle 310 and the drain block 730 is inserted into the bottle mouth of the second collection bottle 320. The second drive pump 710 is used to extract the cleaning solution into the first collection bottle 310 when the spray block 740 is inserted into the bottle mouth of the first collection bottle 310. During the experiment, due to the large volume of sample mixture extracted by the column chromatography apparatus 600, a larger first collection bottle 310 is needed to collect the sample mixture. After separation and purification, the sample in the first collection bottle 310 is transferred to a smaller second collection bottle 320 by washing. Finally, the sample in the second collection bottle 320 is separated and purified, and then transferred to the finished product rack 200 for storage. Transferring the sample to the smaller second collection bottle 320 for storage improves space utilization. In a specific embodiment, the second drive pump 710 can be a peristaltic pump or a combination of a solenoid valve and a metering pump.
[0043] In this embodiment, the sample transfer process is as follows: 1. First, the first collection bottle 310 containing the sample mixture is transferred to the rotary evaporator 400 to evaporate the solvent in the first collection bottle 310, completing the separation and purification of the sample; 2. The first robot 500 is controlled to operate, placing the first collection bottle 310 in the first mounting position 750, the second collection bottle 320 in the second mounting position 760, and the drain block 730 is inserted into the bottle mouth of the second collection bottle 320; 3. The first robot 500 is controlled to operate, inserting the spray block 740 into the bottle mouth of the first collection bottle 310, and the second drive pump 710 is controlled to operate, injecting an appropriate amount of cleaning solution (ethyl acetate solution) into the first collection bottle 310. 4. Control the first robot 500 to remove the first collection bottle 310 from the first mounting position 750 and shake it repeatedly. After shaking, place the first collection bottle 310 back into the first mounting position 750. 5. Control the first robot 500 to insert the suction needle 721 of the suction block 720 into the first collection bottle 310 until the suction needle 721 reaches the bottom of the first collection bottle 310. Control the first drive pump to extract the mixture of sample and cleaning solution from the first collection bottle 310 into the second collection bottle 320. 6. Repeat steps 3-5 until all the sample in the first collection bottle 310 is transferred to the second collection bottle 320. It should be noted that, to simplify the experimental process, the shaking of the first collection bottle 310 in step 4 can be selectively omitted when repeating steps 3-5.
[0044] In one specific embodiment of this invention, the liquid suction block 720 is connected to the first drive pump via a first flexible tube, and the liquid discharge block 730 is connected to the first drive pump via a second flexible tube. A bubble sensor is installed in the first flexible tube. In this embodiment, the bubble sensor detects the presence of bubbles in the first flexible tube and, by monitoring the size and number of bubbles, determines whether the liquid in the first collection bottle 310 has been completely transferred to the second collection bottle 320 during the cleaning of the first collection bottle 310, thereby ensuring that the sample in the first collection bottle 310 is completely transferred to the second collection bottle 320. In another specific embodiment of this invention, a bubble sensor is installed in the second flexible tube; furthermore, to ensure the accuracy of the detection results, bubble sensors can be installed on both the first and second flexible tubes.
[0045] Please see Figure 3 and Figure 4In one embodiment of this utility model, the clamping mechanism 510 further includes a base 512 and a drive cylinder 513. The base 512 is disposed on the first robot 500, and the drive cylinder 513 is disposed on the base 512. There are two grippers 511, and both grippers 511 are disposed on the drive cylinder 513. The drive cylinder 513 can drive the two grippers 511 to move towards or away from each other. In this embodiment, the two grippers 511 are driven by the drive cylinder 513 to move towards or away from each other, clamping or releasing the positioning block 321. This design features a simple structure, simplifying the manufacturing difficulty of the clamping mechanism 510 and thus reducing the manufacturing difficulty of the experimental equipment. Specifically, when the clamping mechanism 510 needs to clamp the positioning block 321, the drive cylinder 513 drives the two grippers 511 to move towards each other, so that the two sides of the insertion block 3211 are respectively inserted into the two slots 5111; when the clamping mechanism 510 needs to release the positioning block 321, the drive cylinder 513 drives the two grippers 511 to move away from each other, so that the insertion block 3211 is disengaged from the slots 5111. In a specific embodiment, the drive cylinder 513 can be a bidirectional drive cylinder 513.
[0046] Please see Figure 4 In a specific embodiment of this utility model, two rollers 5112 are spaced apart on the side of the two grippers 511 facing each other. The outer circumferential surface of the two rollers 5112 is provided with annular grooves 5113. The slot 5111 includes two annular grooves 5113. When the clamping mechanism 510 is in the bottle mouth position of the collection bottle, the drive cylinder 513 can drive the two grippers 511 to move towards each other, so that one side of the insertion block 3211 is simultaneously inserted into the two annular grooves 5113 of one of the grippers 511, and the other side of the insertion block 3211 is simultaneously inserted into the two annular grooves 5113 of the other gripper 511. The outer circumferential surface of each roller 5112 abuts against the positioning block 321 to clamp the positioning block 321. When the clamping mechanism 510 clamps the positioning block 321, by simultaneously inserting the four different positions of the insert 3211 into the annular grooves 5113 of the four rollers 5112 of the two grippers 511, the positioning block 321 can be clamped more accurately and reliably. Furthermore, when the first robot 500 transfers and shakes the collected items, it can effectively prevent the collection bottle from falling during the transfer process. Specifically, by simultaneously inserting the four different positions of the insert 3211 into the annular grooves 5113 of the four rollers 5112 of the two grippers 511, the positioning block 321 can be confined within the space formed by the four rollers 5112, thus clamping the positioning block 321 more accurately and reliably. When the clamping mechanism 510 clamps the positioning block 321, the outer circumferential surface of each roller 5112 abuts against the positioning block 321, which better restricts the position of the positioning block 321, ensuring the stability of the collection bottle's position during transfer and shaking.
[0047] Please see Figure 5 In another specific embodiment of this utility model, each of the two grippers 511 has a slot 5111 on one side facing each other, and the sides of each gripper 511 facing each other are recessed in a direction away from each other to form a groove 5114. When the clamping mechanism 510 clamps the positioning block 321, a portion of the positioning block 321 is accommodated in the groove 5114, and the positioning block 321 abuts against the inner wall surface of the groove 5114. In this embodiment, the two grooves 5114 of the two grippers 511 facing each other can better lock the positioning block 321 when the clamping mechanism 510 clamps the positioning block 321, thereby making the clamping mechanism 510 clamp the positioning block 321 more accurately and reliably.
[0048] Please see Figure 1 and Figure 6 In one embodiment of this utility model, the column chromatography apparatus 600 includes an assembly platform 610, a second placement rack 620, a transfer pump, a transfer rack, and a second robot 630. The second robot 630 is disposed on a base plate 100. The assembly platform 610, the second placement rack 620, and the transfer rack are arranged circumferentially around the second robot 630. The second placement rack 620 holds a chromatographic column 621. The second robot 630 is used to transfer the chromatographic column 621 between the assembly platform 610 and the second placement rack 620. The transfer rack is provided with an outlet and a third mounting position located below the outlet for placing a collection bottle. In this embodiment, the column chromatography apparatus 600 is used to separate and purify components in the stock solution to achieve sample extraction. In a specific embodiment, the second robot 630 can be a multi-degree-of-freedom manipulator.
[0049] Please see Figure 6The assembly table 610 includes a frame 611, a slider 612, a first mounting plate 613, a second mounting plate 614, a drive component 615, and a clamping assembly 616. The first mounting plate 613 is disposed on the frame 611, and the second mounting plate 614 is slidably disposed below the first mounting plate 613 along the height direction of the frame 611. The slider 612 is slidably disposed between the first mounting plate 613 and the second mounting plate 614 along the height direction of the frame 611. The drive component 615 is disposed on the slider 612 and connected to the second mounting plate 614. The clamping assembly 616 is disposed on the slider 612 and is used to clamp the chromatographic column 621. The first mounting plate 613 is provided with a liquid injection connector 6 that communicates with a delivery pump. 131. The second mounting plate 614 is provided with a liquid outlet connector communicating with the liquid outlet head; the slider 612 can move along the height direction of the frame 611 towards the first mounting plate 613 when the clamping assembly 616 clamps the chromatographic column 621, so that the first end of the chromatographic column 621 is connected to the liquid injection connector 6131; the driving member 615 can drive the second mounting plate 614 to slide when the first end of the chromatographic column 621 is connected to the liquid injection connector 6131, so that the second end of the chromatographic column 621 is connected to the liquid outlet connector; the delivery pump is used to draw the stock solution into the chromatographic column 621 when the first end of the chromatographic column 621 is connected to the liquid injection connector 6131 and the second end of the chromatographic column 621 is connected to the liquid outlet connector. In this embodiment, the sliding of the slider 612 along the height direction of the frame 611 is driven by a drive motor. In a specific embodiment, the driving member 615 can be a drive cylinder.
[0050] The column chromatography process is as follows: 1. Control the second robot 630 to transfer the chromatographic column 621 from the second placement rack 620 to the assembly table 610, where the clamping component 616 of the assembly table 610 holds the chromatographic column 621; 2. Control the drive motor to drive the slider 612 to move along the height direction of the frame 611 towards the first mounting plate 613 until the first end of the chromatographic column 621 is connected to the injection connector 6131; 3. Control the drive component 615 to drive the second mounting plate 614 to slide along the height direction of the frame 611 towards the first mounting plate 613 until the second end of the chromatographic column 621 is connected to the outlet connector; 4. After the first robot 500 places the first collection bottle 310 in the third mounting position of the transfer rack, control the delivery pump to extract the original solution into the chromatographic column 621, and inject the sample mixture separated and purified by the chromatographic column 621 into the first collection bottle 310.
[0051] Please see Figure 6 and Figure 7In a specific embodiment of this utility model, both the injection connector 6131 and the outlet connector are provided with an adapter block 617. The adapter block 617 is provided with a guide hole 6171, and the end of the guide hole 6171 near the clamping assembly 616 is provided with a guide cone surface 6172. In this embodiment, by providing the guide cone surface 6172, the first end of the chromatographic column 621 can be more accurately aligned with the injection connector 6131, and the second end of the chromatographic column 621 can be more accurately aligned with the outlet connector. Taking the alignment of the first end of the chromatographic column 621 with the injection connector 6131 as an example, specifically, when the drive motor drives the slider 612 to move along the height direction of the frame 611 towards the first mounting plate 613, the first end of the chromatographic column 621 will gradually insert into the guide hole 6171 under the guidance of the guide cone surface 6172, and align with the injection connector 6131 provided in the guide hole 6171.
[0052] In a specific embodiment of this utility model, the experimental equipment further includes a chromatograph, which includes a main body, multiple test tubes disposed on the main body, and multiple injection pumps connected to each of the multiple test tubes. The injection pumps have a liquid aspiration state and a liquid dispensing state. When the injection pump is in the liquid aspiration state, the chromatographic column 621 and the test tubes are connected through the injection pump; when the injection pump is in the liquid dispensing state, the test tubes and the dispensing head are connected through the injection pump. In this embodiment, by setting up a chromatograph, the accuracy and reliability of sample separation and purification can be ensured. The working process of the chromatograph is as follows (the injection pump is initially in the liquid aspiration state): 1. Each injection pump injects the sample mixture separated and purified by the chromatographic column 621 into the corresponding test tube in sequence; 2. After the extraction of the sample-containing mixture is completed, each injection pump switches from the liquid aspiration state to the liquid dispensing state. At this time, each injection pump injects the sample mixture in the corresponding test tube into the first collection bottle 310 through the dispensing head.
[0053] In an embodiment of the present utility model, weight sensors are provided on the bottom surfaces of the finished product rack 200 and the first placement rack 300. In this embodiment, by providing weight sensors on the bottom surfaces of the finished product rack 200 and the first placement rack 300, it is possible to monitor and judge in real time whether processes such as the transfer and collection of samples are completed. For example: when transferring a sample from the first collection bottle 310 to the second collection bottle 320, after the sample in the first collection bottle 310 is completely transferred to the second collection bottle 320, the first robot 500 will place the first collection bottle 310 back on the first placement rack 300. At this time, the weight sensor provided on the bottom surface of the first placement rack 300 can detect the weight change, and then judge whether the transfer of the sample is completed. In a specific embodiment, the first placement rack 300 includes two placement plates arranged up and down. At least one fixing block that can insert into the first collection bottle 310 and fix the first collection bottle 310 is provided on one of the placement plates, and at least one mounting hole for the second collection bottle 320 to insert is provided on the other placement plate. The finished product rack 200 includes at least one placement plate, and placement holes for the second collection bottle 320 to insert are provided on the placement plate.
[0054] The experimental process of the experimental equipment of the present utility model further includes: after the above-mentioned column chromatography process is completed, controlling the operation of the first robot 500 to transfer the first collection bottle 310 to the rotary evaporation device 400 until the separation and purification of the sample in the first collection bottle 310 are completed; then transferring the first collection bottle 310 to the cleaning rack 700 to perform the above-mentioned sample transfer process; after the above-mentioned sample transfer process is completed, controlling the operation of the first robot 500 to transfer the second collection bottle 320 to the rotary evaporation device 400 until the separation and purification of the sample in the second collection bottle 320 are completed; finally, controlling the operation of the first robot 500 to place the second collection bottle 320 on the finished product rack 200.
[0055] The present utility model also proposes an automatic drying system. This automatic drying system uses a Python controller as the upper computer, communicates with the PLC register through the Modbus protocol to control the equipment, and realizes the interlocking control of the equipment based on the writing and reading of the PLC register value. Among them, the Python controller communicates with the PLC register through the Modbus protocol, sends instructions to the PLC register to control the operation of hardware devices such as the second drive pump 710, ensuring the flexibility and expandability of the system; and the Python controller communicates with the rotary evaporation device 400 through TCP to control the start and stop of rotary evaporation. At the same time, the Python controller will also send instructions to the first robot 500 and the second robot 630 according to experimental requirements to make them perform corresponding actions. The experimental equipment of the present utility model is also equipped with a control module, which controls the automatic operation of each process through a graphical interface and can monitor and record experimental data in real time.
[0056] The above description is merely an exemplary embodiment of the present utility model and does not limit the scope of protection of the present utility model. Any equivalent structural transformations made based on the technical concept of the present utility model and the contents of the present utility model specification and drawings, or direct / indirect applications in other related technical fields, are included within the scope of protection of the present utility model.
Claims
1. An experimental apparatus, characterized in that, The device includes a base plate, a finished product rack, a first placement rack, a rotary evaporator, a first robot, and a column chromatography apparatus. The first robot is disposed on the base plate. The finished product rack, the first placement rack, the rotary evaporator, and the column chromatography apparatus are arranged around the circumference of the first robot. The first placement rack holds at least one collection bottle. The first robot is used to transfer each collection bottle between the finished product rack, the first placement rack, the rotary evaporator, and the column chromatography apparatus. Each of the collection bottles has a positioning block at its mouth, and the positioning block has an annular insert. The first robot has a gripping mechanism, which includes a gripper with a slot. When the gripping mechanism is at the mouth of the collection bottle, the gripper can move toward the positioning block so that the insert is inserted into the slot and clamps the positioning block.
2. The experimental apparatus as described in claim 1, characterized in that, The clamping mechanism further includes a base and a drive cylinder. The base is disposed on the first robot, and the drive cylinder is disposed on the base. There are two grippers, and both grippers are disposed on the drive cylinder. The drive cylinder can drive the two grippers to move in a direction that is closer to or further away from each other.
3. The experimental apparatus as described in claim 2, characterized in that, Two rollers are spaced apart on the side of each of the two grippers that face each other, and annular grooves are provided on the outer circumferential surface of each of the two rollers. The slot includes two annular grooves. When the clamping mechanism is at the bottle mouth position of the collection bottle, the drive cylinder can drive the two grippers to move towards each other, so that one side of the insert block is simultaneously inserted into the two annular grooves of one of the grippers, and the other side of the insert block is simultaneously inserted into the two annular grooves of the other gripper, and the outer circumferential surface of each roller abuts against the positioning block to clamp the positioning block.
4. The experimental apparatus as described in claim 2, characterized in that, The slots are provided on the sides of the two grippers that face each other, and the sides of each gripper that face each other are recessed in a direction away from each other to form a groove. When the clamping mechanism clamps the positioning block, a portion of the positioning block is accommodated in the groove, and the positioning block abuts against the inner wall surface of the groove.
5. The experimental apparatus as described in claim 1, characterized in that, The collection bottle includes at least a first collection bottle and a second collection bottle, wherein the volume of the first collection bottle is greater than the volume of the second collection bottle; the experimental equipment also includes a cleaning rack, which is provided with a first drive pump, a second drive pump, a liquid suction block, a liquid discharge block, a spray block, a first mounting position for placing the first collection bottle and a second mounting position for placing the second collection bottle, wherein the liquid suction block, the liquid discharge block and the spray block are all provided with annular inserts, the liquid suction block is provided with a liquid suction needle, the liquid suction block and the liquid discharge block are both connected to the first drive pump, and the spray block is connected to the second drive pump; The first robot is used to grip and transfer the first collection bottle, the second collection bottle, the suction block, the drain block, and the spray block; the first drive pump is used to extract the sample mixture in the first collection bottle into the second collection bottle when the suction needle of the suction block is inserted into the first collection bottle and the drain block is inserted into the bottle opening of the second collection bottle; the second drive pump is used to extract the cleaning solution into the first collection bottle when the spray block is inserted into the bottle opening of the first collection bottle.
6. The experimental apparatus as described in claim 5, characterized in that, The liquid suction block is connected to the first drive pump through a first hose, and the liquid discharge block is connected to the first drive pump through a second hose. Both the first hose and / or the second hose are equipped with bubble sensors.
7. The experimental apparatus as described in claim 1, characterized in that, The column chromatography apparatus includes an assembly platform, a second placement rack, a delivery pump, a transfer rack, and a second robot. The second robot is mounted on the base plate. The assembly platform, the second placement rack, and the transfer rack are arranged circumferentially around the second robot. The second placement rack holds a chromatographic column. The second robot is used to transfer the chromatographic column between the assembly platform and the second placement rack. The transfer rack is provided with an outlet and a third mounting position located below the outlet for placing a collection bottle. The assembly table includes a frame, a slider, a first mounting plate, a second mounting plate, a drive component, and a clamping assembly. The first mounting plate is disposed on the frame, and the second mounting plate is slidably disposed below the first mounting plate along the height direction of the frame. The slider is slidably disposed between the first mounting plate and the second mounting plate along the height direction of the frame. The drive component is disposed on the slider and connected to the second mounting plate. The clamping assembly is disposed on the slider and used to clamp the chromatographic column. The first mounting plate is provided with a liquid injection connector communicating with the delivery pump, and the second mounting plate is provided with... The system includes a liquid outlet connector communicating with the liquid outlet head; the slider can move along the height direction of the frame towards the first mounting plate when the clamping assembly holds the chromatographic column, so that the first end of the chromatographic column is connected to the liquid injection connector; the driving member can drive the second mounting plate to slide when the first end of the chromatographic column is connected to the liquid injection connector, so that the second end of the chromatographic column is connected to the liquid outlet connector; the delivery pump is used to draw the stock solution into the chromatographic column when the first end of the chromatographic column is connected to the liquid injection connector and the second end of the chromatographic column is connected to the liquid outlet connector.
8. The experimental apparatus as described in claim 7, characterized in that, Both the injection connector and the outlet connector are provided with adapter blocks, each adapter block is provided with a guide hole, and the end of the guide hole near the clamping assembly is provided with a guide cone surface.
9. The experimental apparatus as described in claim 7, characterized in that, The experimental equipment also includes a chromatograph, which includes a main body, multiple test tubes disposed on the main body, and multiple injection pumps that are connected to each of the multiple test tubes in a one-to-one correspondence. The injection pumps include a liquid aspiration state and a liquid discharging state. When the syringe pump is in the liquid aspiration state, the chromatographic column and the test tube are connected through the syringe pump; when the syringe pump is in the liquid discharging state, the test tube and the liquid outlet are connected through the syringe pump.
10. The experimental apparatus as described in any one of claims 1 to 9, characterized in that, Both the finished product rack and the first placement rack have weight sensors installed on their bottom surfaces.